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https://www.readbyqxmd.com/read/29756392/successful-treatment-of-severe-facial-lymphedema-by-lymphovenous-anastomosis
#1
Yusuke Inatomi, Sei Yoshida, Kenichi Kamizono, Masuo Hanada, Ryuji Yasumatsu, Hideki Kadota
BACKGROUND: Facial edema is a common complication after neck dissection and/or chemoradiotherapy for head and neck cancer. Edema subsides spontaneously in most cases but sometimes persists, in which case surgical intervention is required. We report a case of severe facial edema that showed significant improvement upon lymphovenous anastomosis (LVA). METHODS: A 66-year-old man with oral floor cancer developed progressive facial lymphedema after tumor resection, bilateral neck dissections, chemoradiotherapy, and fibular and rectus abdominis musculocutaneous flap transfer...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29753301/the-recipient-venule-in-supermicrosurgical-lymphaticovenular-anastomosis-flow-dynamic-classification-and-correlation-with-surgical-outcomes
#2
Giuseppe Visconti, Marzia Salgarello, Akitatsu Hayashi
BACKGROUND:  Venules have been usually neglected in the literature on lymphaticovenular anastomosis (LVA). The aim of this study was to analyze the flow dynamic of recipient venules in LVA and their impact on the surgical outcomes. PATIENTS AND METHODS:  Data from 128 patients affected by extremity lymphedema, who underwent LVA, were collected in two institutions from August 2014 to May 2016. Recipient venules were classified according to their flow dynamic into backflow, slack, and outlet (BSO classification)...
May 12, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29723882/cumulative-experience-in-lymphovenous-anastomosis-for-lymphedema-treatment-the-learning-curve-effect-on-the-overall-outcome
#3
Nicolas Pereira, Yeon Hoon Lee, Youngchul Suh, Dong Hoon Choi, Hyun Suk Suh, Jae Yong Jeon, Joon Pio Jp Hong
BACKGROUND:  The lymphovenous anastomosis (LVA) has become one of the treatment options for lymphedema. However, it is regarded as a difficult surgery that many young microsurgeons are reluctant to try. This report investigates the learning curve in regard to symptom improvement. METHOD:  This is a retrospective analysis performed in 33 consecutive lymphedema patients (38 extremities) who underwent only LVAs from August 2010 to February 2016. Surgical outcomes in regard to surgeon's experience were evaluated...
May 3, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29719080/lymphovenous-anastomosis-and-debulking-procedure-for-treatment-of-combined-severe-lower-extremity-and-genital-lymphedema-a-case-report
#4
Mario F Scaglioni, Semra Uyulmaz
Lymphedema most commonly occurs after cancer treatment and can affect limbs and genitalia. Genital lymphedema (GL) is a rare condition and can be disabling psychologically and physically. It often occurs along with lower extremity lymphedema (LEL). Conservative and physiologic reconstructive surgery such as lymphaticovenous anastomosis (LVA) offer good treatment options for LEL. GL however remains a reconstructive dilemma. The most effective surgical therapies in advanced GL are still debulking procedures in properly selected patients...
May 2, 2018: Microsurgery
https://www.readbyqxmd.com/read/29689576/a-prospective-evaluation-of-health-related-quality-of-life-following-lymphaticovenular-anastomosis-for-upper-and-lower-extremities-lymphedema
#5
Marzia Salgarello, Maria Lucia Mangialardi, Valentina Pino, Stefano Gentileschi, Giuseppe Visconti
BACKGROUND:  Lymphedema is a progressive disease that negatively affects body image and physical, psychological, and social functions. There is lack of evidence in the present literature about the impact of super microsurgical lymphaticovenular anastomosis (LVA) on health-related quality of life (HRQoL). The aim of this prospective study is to report the outcomes of patients' HRQoL after LVA for lower and upper extremities lymphedema. METHODS:  Between September 2015 and February 2017, 74 patients with upper or lower limb lymphedema (ULL or LLL) underwent LVA at our center...
April 24, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29657593/not-all-rotors-effective-ablation-targets-for-nonparoxysmal-atrial-fibrillation-are-included-in-areas-suggested-by-conventional-indirect-indicators-of-atrial-fibrillation-drivers-extra-mapping-project
#6
Kensuke Sakata, Yusuke Okuyama, Tomoya Ozawa, Ryo Haraguchi, Kazuo Nakazawa, Takeshi Tsuchiya, Minoru Horie, Takashi Ashihara
Background: Effects of nonparoxysmal atrial fibrillation (non-PAF) ablation targeting complex fractionated atrial electrogram (CFAE) areas and/or low voltage areas (LVAs) are still controversial. Methods and Results: A recently developed online real-time phase mapping system (ExTRa Mapping) was used to conduct LVA mapping and simultaneous ExTRa and CFAE mapping in 28 non-PAF patients after pulmonary vein isolation (PVI). Nonpassively activated areas, in the form of meandering rotors and/or multiple wavelets assumed to contain non-PAF drivers, partly overlapped with CFAE/LVAs but not always coincided with them...
April 2018: Journal of Arrhythmia
https://www.readbyqxmd.com/read/29616175/single-lymphaticovenular-anastomosis-for-early-stage-lower-extremity-lymphedema-treated-by-the-superior-edge-of-the-knee-incision-method
#7
Yukio Seki, Akiyoshi Kajikawa, Takumi Yamamoto, Takayuki Takeuchi, Takahiro Terashima, Norimitsu Kurogi
Background: Surgical treatment of lower extremity lymphedema (LEL) remains challenging. Application of the superior-edge-of-the-knee incision method for lymphaticovenular anastomosis (LVA) is reported to have a strong therapeutic effect in patients with LEL because lymph-to-venous flow at the anastomosis is enhanced by knee joint movement during normal walking. We investigated whether a single LVA created by this method is adequate for early LEL. Methods: The study involved 10 patients with LEL characterized by stage 2 or 3 leg dermal backflow and treated by a single LVA at the thigh via the superior-edge-of-the-knee incision method...
February 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29604419/the-role-of-nt-proanp-and-nt-probnp-in-af-patients-association-with-af-progression-phenotypes
#8
Petra Büttner, Katja Schumacher, Borislav Dinov, Samira Zeynalova, Philipp Sommer, Andreas Bollmann, Daniela Husser, Gerhard Hindricks, Jelena Kornej
BACKGROUND: Electro-anatomical remodeling in atrial fibrillation (AF) leads to disease initiation and perpetuation. While atrial natriuretic peptide (ANP) is specifically expressed in the atria and is involved in atrial remodeling, B-type natriuretic peptide (BNP) is associated with mortality and cardiovascular events in AF. OBJECTIVE: To investigate association between NT-proBNP and NT-proANP levels with three AF progression phenotypes: persistent AF, left atrial diameter (LAD) dilatation and left atrial low voltage areas (LVA)...
March 28, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29601634/intraoperative-identification-and-definition-of-functional-lymphatic-collecting-vessels-for-supermicrosurgical-lymphatico-venous-anastomosis-in-treating-lymphedema-patients
#9
Johnson Chia-Shen Yang, Shao-Chun Wu, Min-Hsien Chiang, Wei-Che Lin, Ching-Hua Hsieh
BACKGROUND: For current lymphatico-venous anastomosis (LVA), the identification of "functional" lymphatic collecting vessels (LCVs) is mainly based on indocyanine green (ICG) lymphography. However, some of the non-ICG enhanced LCVs utilized for LVA were found to have visual lymphatic flow. OBJECTIVES: Should non-ICG enhanced, but flow-positive LCVs be considered functional as well? METHODS: A retrospective study with 56 consecutive lymphedema patients (8 male/48 female) received LVA...
March 30, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29581714/congenital-left-ventricular-aneurysms-and-diverticula-an-entity-in-search-of-an-identity
#10
REVIEW
Marc-Alexander Ohlow
Congenital left ventricular aneurysm or diverticulum are rare cardiac malformations described in 809 cases since the first description in 1816, being associated with other cardiac, vascular or thoraco-abdominal abnormalities in about 70%. It appears to be a developmental anomaly, starting in the 4th embryonic week. In an experimental study, targeted knockdown of cardiac troponin T in the chick was performed at day 3, after the heart tube has formed. Morpholino treatment of gene TNNT2 at this stage led to the development of left ventricular diverticula (LVD) in the primitive left ventricular wall...
December 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29556214/calcium-channels-in-postnatal-development-of-rat-pancreatic-beta-cells-and-their-role-in-insulin-secretion
#11
Neivys García-Delgado, Myrian Velasco, Carmen Sánchez-Soto, Carlos Manlio Díaz-García, Marcia Hiriart
Pancreatic beta cells during the first month of development acquire functional maturity, allowing them to respond to variations in extracellular glucose concentration by secreting insulin. Changes in ionic channel activity are important for this maturation. Within the voltage-gated calcium channels (VGCC), the most studied channels are high-voltage-activated (HVA), principally L-type; while low-voltage-activated (LVA) channels have been poorly studied in native beta cells. We analyzed the changes in the expression and activity of VGCC during the postnatal development in rat beta cells...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29474447/contribution-of-s4-segments-and-s4-s5-linkers-to-the-low-voltage-activation-properties-of-t-type-cav3-3-channels
#12
Ana Laura Sanchez-Sandoval, Zazil Herrera Carrillo, Clara Estela Díaz Velásquez, Dulce María Delgadillo, Heriberto Manuel Rivera, Juan Carlos Gomora
Voltage-gated calcium channels contain four highly conserved transmembrane helices known as S4 segments that exhibit a positively charged residue every third position, and play the role of voltage sensing. Nonetheless, the activation range between high-voltage (HVA) and low-voltage (LVA) activated calcium channels is around 30-40 mV apart, despite the high level of amino acid similarity within their S4 segments. To investigate the contribution of S4 voltage sensors for the low-voltage activation characteristics of CaV3...
2018: PloS One
https://www.readbyqxmd.com/read/29459992/a-systematic-classification-of-the-vertebral-artery-variable-origin-clinical-and-surgical-implications
#13
REVIEW
Nikolaos Lazaridis, Maria Piagkou, Marios Loukas, Evangelia-Theophano Piperaki, Trifon Totlis, Georgios Noussios, Konstantinos Natsis
Several congenital anomalies regarding the right (RVA) and left (LVA) vertebral artery have been described. The current paper aims to perform a systematic literature review of the variable vertebral artery (VA) origin from the aortic arch (AOA) and its branches. The incidence of these variants and the ensuing AOA branching pattern are highlighted. Atypical origin cases were found more commonly unilaterally, while LVA presented the majority of the aberrancies. The LVA emersion from the AOA (3.6%) and the RVA from the right common carotid artery (RCCA) (0...
February 19, 2018: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/29420707/association-of-left-ventricular-late-gadolinium-enhancement-with-left-atrial-low-voltage-areas-in-patients-with-atrial-fibrillation
#14
Clara Stegmann, Cosima Jahnke, Ingo Paetsch, Sebastian Hilbert, Arash Arya, Andreas Bollmann, Gerhard Hindricks, Philipp Sommer
Aims: Presence of late gadolinium enhancement (LGE) is related to adverse cardiovascular outcome. Many patients suffering from atrial fibrillation (AF) undergo cardiovascular magnetic resonance (CMR) imaging prior to ablation. Since quantification of atrial fibrosis still lacks reproducibility, we sought to investigate risk factors for the presence of left ventricular (LV)-LGE and a possible correlation between ventricular fibrosis as defined by positive LGE and pathological atrial voltage maps evaluated by 3D mapping systems...
February 6, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29403014/deaminase-mediated-multiplex-genome-editing-in-escherichia-coli
#15
Satomi Banno, Keiji Nishida, Takayuki Arazoe, Hitoshi Mitsunobu, Akihiko Kondo
In eukaryotes, the CRISPR-Cas9 system has now been widely used as a revolutionary genome engineering tool1, 2 . However, in prokaryotes, the use of nuclease-mediated genome editing tools has been limited to negative selection for the already modified cells because of its lethality3, 4 . Here, we report on deaminase-mediated targeted nucleotide editing (Target-AID) 5 adopted in Escherichia coli. Cytidine deaminase PmCDA1 fused to the nuclease-deficient CRISPR-Cas9 system achieved specific point mutagenesis at the target sites in E...
April 2018: Nature Microbiology
https://www.readbyqxmd.com/read/29390369/acupuncture-for-vertebrobasilar-insufficiency-vertigo-protocol-for-a-systematic-review-and-meta-analysis
#16
REVIEW
Xiaohui Li, Menghui Liu, Yu Zhang, Ziqing Li, Dawei Wang, Xia Yan
BACKGROUND: Vertebrobasilar insufficiency vertebrobasilar (VBIV) is a serious nerve disease and many old people suffer from it. Acupuncture has been widely applied in the treatment of VBIV. However, to our knowledge, there has been no systematic review or meta-analysis of randomized controlled trails regarding the effectiveness of this treatment. Here, we provide a protocol to evaluate the effectiveness and safety of acupuncture for VBIV. METHODS: Relevant randomized controlled trials in 5 databases (EMBASE, PubMed, the Cochrane Central Register of Controlled Trials [Cochrane Library], Chinese Biomedical Literature Database [CBM], China National Knowledge Infrastructure [CNKI]) will be comprehensively searched by 2 researchers in December 2017...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29356596/the-effect-of-lymphaticovenous-anastomosis-in-breast-cancer-related-lymphedema-a-review-of-the-literature
#17
Anouk J M Cornelissen, Jop Beugels, Lotte Ewalds, Esther M Heuts, Xavier H A Keuter, Andrzej Piatkowski, René R W J van der Hulst, Shan Shan Qiu Shao
BACKGROUND: Lymphedema affects ∼15% of all patients after breast cancer treatment. The aim of this review was to assess the clinical effects (improvement in arm circumference and quality of life) of lymphaticovenous anastomosis (LVA) in treating breast cancer-related lymphedema (BCRL). METHODS AND RESULTS: A systematic literature search was conducted in Medline, Embase and the Cochrane Library in July 2017, to identify all studies on LVA for the treatment of BCRL...
January 22, 2018: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/29355996/lymphatic-vessel-diameter-in-female-pelvic-cancer-related-lower-extremity-lymphedematous-limbs
#18
Takumi Yamamoto, Mitsunaga Narushima, Isao Koshima
BACKGROUND: Lymphaticovenular anastomosis (LVA) has become one of the useful surgical treatments for compression-refractory lower extremity lymphedema (LEL). It is important to anastomose larger lymphatic vessels with abundant lymph flows in LVA surgery. This study aimed to clarify factors associated with lymphatic vessel diameter. METHODS: One hundred thirty-four LEL patients who underwent pre-operative indocyanine green (ICG) lymphography and LVA from June 2009 to August 2014 in a single institution were included in this retrospective observational study...
January 22, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29338554/site-specific-evaluation-of-lymphatic-vessel-sclerosis-in-lower-limb-lymphedema-patients
#19
Makoto Mihara, Hisako Hara, Yoshihisa Kawakami, Han Peng Zhou, Shuichi Tange, Kazuki Kikuchi, Takuya Iida
BACKGROUND: Histological changes in the collecting lymphatics in patients with lymphedema are classified as Normal type, Ectasis type, Contraction type, and Sclerosis type (NECST) classification. In this study, we investigated the condition of the lymphatic vessels in different sites of the legs. PATIENTS AND METHODS: We prospectively investigated the lymphatic vessels of patients with lymphedema who underwent lymphaticovenous anastomosis (LVA) from August 8, 2014 to August 4, 2015 based on the NECST classification...
January 17, 2018: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/29327607/up-regulation-of-cav3-1-expression-in-sh-sy5y-cells-induced-by-lidocaine-hydrochloride
#20
Qin Gong, Xianjie Wen, Heng Li, Jian He, Yunhua Wang, Huiping Wu, Hanbing Wang, Xiaoping Wang
BACKGROUND: Neurotoxicity induced by the local anaesthetics has aroused concern. A previous study has shown that an overload of intracellular calcium was involved in the neurotoxic effect. Cav3.1 is one of the low-voltage-activated (LVA) calcium channels which play a key point to regulate the intracellular calcium ion level. This study aimed to investigate the changes of the Cav3.1 expression in the SH-SY5Y cells treated with lidocaine hydrochloride. METHODS: The SH-SY5Y cells were treated with different concentrations of lidocaine hydrochloride(1 mM, 5 mM and 10 mM, namely L1 group, L5 group and L10 group) and different exposure times (1 h,12 h and 24 h), respectively...
January 12, 2018: Artificial Cells, Nanomedicine, and Biotechnology
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