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https://www.readbyqxmd.com/read/29756109/first-experience-with-a-new-technique-portable-gamma-camera-usage-for-sentinel-lymph-node-identification-in-a-patient-with-breast-cancer
#1
Zehra Pınar Koç, Pınar Pelin Özcan Kara, Mustafa Berkeşoğlu, Tamer Akça
The newest development in sentinel lymph node imaging is portable gamma probe imaging. In this case report, results of all SLN detection methods were analyzed. The patient was imaged using a large field-of-view gamma camera with additional blue dye administration and intraoperative localization of sentinel lymph node using both gamma probe and portable gamma camera was performed. In this case report, the value of additional portable gamma camera imaging was analyzed.
2018: Turkish Journal of Surgery
https://www.readbyqxmd.com/read/29728234/novel-light-guide-pmt-geometries-to-reduce-dead-edges-of-a-scintillation-camera
#2
Beien Wang, Rob Kreuger, Freek J Beekman, Marlies C Goorden
Anger cameras based on monolithic NaI scintillators read out by an array of PMTs are predominant in planar gamma imaging and SPECT. However, position estimation of gamma interactions is usually severely degraded near the edges of the scintillator which can be extremely undesirable for applications like breast imaging. Here we propose a relatively cost-effective solution based on the use of scintillators with absorptive edges with an unconventional light-guide-PMT layout employing a maximum likelihood positioning algorithm...
April 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29724381/pulmonary-deposition-of-fluticasone-propionate-formoterol-in-healthy-volunteers-asthmatics-and-copd-patients-with-a-novel-breath-triggered-inhaler
#3
Dominik Kappeler, Knut Sommerer, Claudius Kietzig, Bärbel Huber, Jo Woodward, Mark Lomax, Prashant Dalvi
INTRODUCTION: A combination of fluticasone propionate/formoterol fumarate (FP/FORM) has been incorporated within a novel, breath-triggered device, named K-haler® . This low resistance device requires a gentle inspiratory effort to actuate it, triggering at an inspiratory flow rate of approximately 30 L/min; thus avoiding the need for coordination of inhalation with manual canister depression. The aim of the study was to evaluate total and regional pulmonary deposition of FP/FORM when administered via the K-haler device...
May 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29721070/tumor-targeted-dual-modality-imaging-to-improve-intraoperative-visualization-of-clear-cell-renal-cell-carcinoma-a-first-in-man-study
#4
Marlène C Hekman, Mark Rijpkema, Constantijn H Muselaers, Egbert Oosterwijk, Christina A Hulsbergen-Van de Kaa, Otto C Boerman, Wim J Oyen, Johan F Langenhuijsen, Peter F Mulders
Intraoperative imaging with antibodies labeled with both a radionuclide for initial guidance and a near-infrared dye for adequate tumor delineation may overcome the main limitation of fluorescence imaging: the limited penetration depth of light in biological tissue. In this study, we demonstrate the feasibility and safety of intraoperative dual-modality imaging with the carbonic anhydrase IX (CAIX)-targeting antibody 111 In-DOTA-girentuximab-IRDye800CW in clear cell renal cell carcinoma (ccRCC) patients. Methods: A phase I protein dose escalation study was performed in patients with a primary renal mass who were scheduled for surgery...
2018: Theranostics
https://www.readbyqxmd.com/read/29717385/determination-of-gamma-camera-calibration-factors-for-quantitation-of-therapeutic-radioisotopes
#5
Wei Zhao, Pedro L Esquinas, Xinchi Hou, Carlos F Uribe, Marjorie Gonzalez, Jean-Mathieu Beauregard, Yuni K Dewaraja, Anna Celler
BACKGROUND: Camera calibration, which translates reconstructed count map into absolute activity map, is a prerequisite procedure for quantitative SPECT imaging. Both planar and tomographic scans using different phantom geometries have been proposed for the determination of the camera calibration factor (CF). However, there is no consensus on which approach is the best. The aim of this study is to evaluate all these calibration methods, compare their performance, and propose a practical and accurate calibration method for SPECT quantitation of therapeutic radioisotopes...
May 2, 2018: EJNMMI Physics
https://www.readbyqxmd.com/read/29664326/targeted-alpha-particle-therapy-imaging-dosimetry-and-radiation-protection
#6
M Lassmann, U Eberlein
Systemic or locoregionally administered alpha-particle emitters are highly potent therapeutic agents used in oncology that are fundamentally novel in their mechanism and, most likely, overcome radiation resistance as the alpha particles emitted have a short range and a high linear energy transfer. The use of alpha emitters in a clinic environment requires extra measures with respect to imaging, dosimetry, and radiation protection. This is shown for the example of 223 Ra dichloride therapy. After intravenous injection, 223 Ra leaves the blood and is taken up rapidly in bone and bone metastases; it is mainly excreted via the intestinal tract...
January 1, 2018: Annals of the ICRP
https://www.readbyqxmd.com/read/29663429/remote-cherenkov-imaging-based-quality-assurance-of-a-magnetic-resonance-image-guided-radiotherapy-system
#7
Jacqueline M Andreozzi, Karen E Mooney, Petr Brůža, Austen Curcuru, David J Gladstone, Brian W Pogue, Olga Green
PURPOSE: Tools to perform regular quality assurance of magnetic resonance image-guided radiotherapy (MR-IGRT) systems should ideally be independent of interference from the magnetic fields. Remotely acquired optical Cherenkov imaging-based dosimetry measurements in water were investigated for this purpose, comparing measures of dose accuracy, temporal dynamics, and overall integrated IMRT delivery. METHODS: A 40x30.5x37.5cm3 water tank doped with 1g/L of quinine sulfate was imaged using an intensified charge coupled device (ICCD) to capture the Cherenkov emission while being irradiated by a commercial MR-IGRT system (ViewRay™ )...
April 16, 2018: Medical Physics
https://www.readbyqxmd.com/read/29652748/the-scintigraphic-biodistribution-and-histopathological-evaluation-of-the-effect-of-experimental-131i-administration-on-the-gastrointestinal-system-and-the-demonstration-of-the-na-i-symporter-by-immunohistochemistry-in-rats
#8
Rahsan Yilmaz, Nihat Yumusak, Murat Sadic, Hasan I Atilgan, Meliha Korkmaz, Faruk Bozkaya
OBJECTIVE: The aim of this study was to investigate histopathological changes and biodistribution of iodine-131 (I) in the gastrointestinal system (GIS) and also Na/I Symporter (NIS) presence by immunohistochemically in the experimental treatment of rats with radioactive iodine (RAI). MATERIALS AND METHODS: Rats were divided into experimental and control groups as random early group 2 (24 h), intermediate group 3 (3 weeks), and late period group 4 (3 months). Experimental groups were administered 100 MBq (∼3 mCi, 12 mCi/kg) by orogastric route with orogastric tube...
April 12, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29644706/preparation-and-evaluation-of-188-re-sulfide-colloidal-nanoparticles-loaded-biodegradable-poly-l-lactic-acid-microspheres-for-radioembolization-therapy
#9
Mina Jamre, Mojtaba Shamsaei, Mostafa Erfani, Sodeh Sadjadi, Mohammad Ghannadi Maragheh
Radioembolization with radioactive microspheres has been an effective method for the treatment of liver lesions. The aim of this study was to prepare carrier-free 188 Re loaded poly (L-lactic acid) (PLLA) microspheres through 188 Re sulfide colloidal nanoparticles (188 Re-SC nanoparticles). The formation of 188 Re-SC nanoparticles was confirmed by ultraviolet-visible spectrophotometry. The labeling yield of 188 Re-SC nanoparticles was verified using the RTLC method. Effects of synthesis parameters on morphology and size of prepared 188 Re-sulfide colloidal-PLLA microspheres (188 Re-SC-PLLA microspheres) were studied by scanning electron microscopy...
April 12, 2018: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29626944/molecular-imaging-of-inflammatory-arthritis-and-related-disorders
#10
REVIEW
François Jamar, Annibale Versari, Filippo Galli, Frédéric Lecouvet, Alberto Signore
Rheumatic disorders comprise a number of diseases that range from benign, mildly symptomatic degenerative disease to severe systemic disorders such as giant-cell vasculitis with dramatic consequences such as acute blindness. The former is relatively common, whereas the latter is rare. In between, commonly encountered disorders such as rheumatoid arthritis and the various spondyloarthritides, with or without peripheral enthesitis, are daily challenges for the caring physician. Clinical evaluation is of utmost importance and is constantly described under the form of specialist guidelines in all parts of the world...
May 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29604781/scalable-gamma-ray-camera-for-wide-area-search-based-on-silicon-photomultipliers-array
#11
Manhee Jeong, Benjamin Van, Byron T Wells, Lawrence J D'Aries, Mark D Hammig
Portable coded-aperture imaging systems based on scintillators and semiconductors have found use in a variety of radiological applications. For stand-off detection of weakly emitting materials, large volume detectors can facilitate the rapid localization of emitting materials. We describe a scalable coded-aperture imaging system based on 5.02 × 5.02 cm2 CsI(Tl) scintillator modules, each partitioned into 4 × 4 × 20 mm3 pixels that are optically coupled to 12 × 12 pixel silicon photo-multiplier (SiPM) arrays...
March 2018: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29603784/a-novel-tc-99m-and-fluorescence-labeled-arginine-arginine-leucine-containing-peptide-as-a-multimodal-tumor-imaging-agent-in-a-murine-tumor-model
#12
Myoung Hyoun Kim, Seul-Gi Kim, Dae-Weung Kim
We developed a Tc-99m and TAMRA labeled peptide, Tc-99m Arginine-Arginine-Leucine (RRL) peptide (TAMRA-GHEG-ECG-RRL) to target tumor cells, and evaluated the diagnostic performance of Tc-99m TAMRA-GHEG-ECG-RRL as a dual-modality imaging agent for tumor in a murine model. TAMRA-GHEG-ECG-RRL was synthesized using Fmoc solid-phase peptide synthesis. Binding affinity and in vitro cellular uptake studies were performed. Gamma camera imaging, biodistribution and ex vivo imaging studies were performed in murine models with PC-3 tumors...
March 30, 2018: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29599399/molecular-breast-imaging-administered-activity-does-not-require-adjustment-based-on-patient-size
#13
Thuy D Tran, Lacey R Ellingson, Tiffinee N Swanson, Courtney M Solberg, Michael K O'Connor, Carrie B Hruska
Objective: At our institution, MBI is performed with 300 MBq Tc-99m sstamibi for all patients. For some nuclear medicine procedures, administered activity or imaging time is increased for patients of larger size in order to obtain adequate counts. Our objective was to assess whether uptake of Tc-99m sestamibi in the breast is influenced by patient size. Methods: Records from patients who underwent a clinical MBI examination between July - November 2016 were reviewed. Those in whom our standard injection and preparation techniques were followed were included in the analysis [3,4]...
March 29, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/29574889/system-for-image-guided-resection-of-non-palpable-breast-lesions-proof-of-concept
#14
Bruno Arsenali, Hugo W A M de Jong, Max A Viergever, Kenneth G A Gilhuijs
PURPOSE: In breast-conserving surgery (BCS), the cancer is sometimes incompletely excised, leading to reduced patient survival. To pursue complete excisions, radioactive seed localization (RSL) may be used to insert an iodine-125 seed into the tumor. The seed is used as a marker for the location of the tumor during surgery. RSL does not, however, show the extent of the tumor. Based on RSL, we pursue to visualize the seed location together with the tumor extent from diagnostic images. METHODS: A system with two gamma camera heads and two parallel-hole collimators was recently proposed to triangulate the location of an iodine-125 seed during BCS...
March 25, 2018: Medical Physics
https://www.readbyqxmd.com/read/29572848/experimental-validation-of-absolute-spect-ct-quantification-for-response-monitoring-in-breast-cancer
#15
Angela Collarino, Lenka M Pereira Arias-Bouda, Renato A Valdés Olmos, Pieternel van der Tol, Petra Dibbets-Schneider, Lioe-Fee de Geus-Oei, Floris Hp van Velden
PURPOSE: Recent developments in iterative image reconstruction enable absolute quantification of SPECT/CT studies by incorporating compensation for collimator-detector response, attenuation and scatter as well as resolution recovery into the reconstruction process (Evolution; Q.Metrix package; GE Healthcare). The aim of this experimental study is to assess its quantitative accuracy for potential clinical 99m Tc-sestamibi (MIBI)-related SPECT/CT application in neoadjuvant chemotherapy response studies in breast cancer...
March 23, 2018: Medical Physics
https://www.readbyqxmd.com/read/29554644/radioiodinated-esmolol-as-a-highly-selective-radiotracer-for-myocardial-perfusion-imaging-in-silico-study-and-preclinical-evaluation
#16
Tamer M Sakr, M H Sanad, Walaa H Abd-Alla, Dina H Salama, Gehan M Saleh
Challenges facing cardiovascular imaging necessitate innovation of better radiopharmaceuticals to augment or replace the existing ones. This research assesses the ability and competency of radioiodinated esmolol as a potential cardio selective imaging agent. Radioiodinated esmolol was synthesized with 97.3 ± 0.3% radiochemical yield and with high stability up to 48 h at room temperature as well as in rat serum. Molecular modeling study was performed to confirm the binding of iodinated esmolol to β1 -adrenergic receptor...
March 9, 2018: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29549769/hybrid-vision-fusion-system-for-whole-body-scintigraphy
#17
Marko Barjaktarović, Milica M Janković, Marija Jeremić, Milovan Matović
Radioiodine therapy in the treatment of differentiated thyroid carcinoma (DTC) is used in clinical practice for the ablation of thyroid residues and/or destruction of tumour tissue. Whole-body scintigraphy for visualization of the spatial 131I distribution performed by a gamma camera (GC) is a standard procedure in DTC patients after application of radioiodine therapy. A common problem is the precise topographic localization of regions where radioiodine is accumulated even in SPECT imaging. SPECT/CT can provide precise topographic localization of regions where radioiodine is accumulated, but it is often unavailable, especially in developing countries because of the high price of the equipment...
May 1, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29546850/a-low-count-reconstruction-algorithm-for-compton-based-prompt-gamma-imaging
#18
Hsuan-Ming Huang, Chih-Chieh Liu, Meei-Ling Jan, Ming-Wei Lee
The Compton camera is an imaging device which has been proposed to detect prompt gammas (PGs) produced by proton-nuclear interactions within tissue during proton beam irradiation. Compton-based PG imaging has been developed to verify proton ranges because PG rays, particularly characteristic ones, have strong correlations with the distribution of the proton dose. However, accurate image reconstruction from characteristic PGs is challenging because the detector efficiency and resolution are generally low. Our previous study showed that point spread functions can be incorporated into the reconstruction process to improve image resolution...
April 19, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29498361/characterization-of-highly-multiplexed-monolithic-pet-gamma-camera-detector-modules
#19
L A Pierce, S Pedemonte, D DeWitt, L MacDonald, W C J Hunter, K Van Leemput, R Miyaoka
PET detectors use signal multiplexing to reduce the total number of electronics channels needed to cover a given area. Using measured thin-beam calibration data, we tested a principal component based multiplexing scheme for scintillation detectors. The highly-multiplexed detector signal is no longer amenable to standard calibration methodologies. In this study we report results of a prototype multiplexing circuit, and present a new method for calibrating the detector module with multiplexed data. A [Formula: see text] mm3 LYSO scintillation crystal was affixed to a position-sensitive photomultiplier tube with [Formula: see text] position-outputs and one channel that is the sum of the other 64...
March 29, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29497588/in-flight-observation-of-gamma-ray-glows-by-ildas
#20
Pavlo Kochkin, A P J van Deursen, M Marisaldi, A Ursi, A I de Boer, M Bardet, C Allasia, J-F Boissin, F Flourens, N Østgaard
An Airbus A340 aircraft flew over Northern Australia with the In-Flight Lightning Damage Assessment System (ILDAS) installed onboard. A long-duration gamma ray emission was detected. The most intense emission was observed at 12 km altitude and lasted for 20 s. Its intensity was 20 times the background counts, and it was abruptly terminated by a distant lightning flash. In this work we reconstruct the aircraft path and event timeline. The glow-terminating flash triggered a discharge from the aircraft wing that was recorded by a video camera operating onboard...
December 16, 2017: Journal of Geophysical Research. Atmospheres: JGR
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