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https://www.readbyqxmd.com/read/29324929/our-solution-for-fusion-of-simultaneusly-acquired-whole-body-scintigrams-and-optical-images-as-usesful-tool-in-clinical-practice-in-patients-with-differentiated-thyroid-carcinomas-after-radioiodine-therapy-a-useful-tool-in-clinical-practice
#1
Milovan Matovic, Milica Jankovic, Marko Barjaktarovic, Marija Jeremic
OBJECTIVE: After radioiodine therapy of differentiated thyroid cancer (DTC) patients, whole body scintigraphy (WBS) is standard procedure before releasing the patient from the hospital. A common problem is the precise localization of regions where the iod-avide tissue is located. Sometimes is practically impossible to perform precise topographic localization of such regions. METHOD: In order to face this problem, we have developed a low-cost Vision-Fusion system for web-camera image acquisition simultaneously with routine scintigraphic whole body acquisition including the algorithm for fusion of images given from both cameras...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29324928/individual-kidney-depth-determination-is-mandatory-to-assess-split-renal-function-in-nephrography-irrespective-of-age
#2
Helmut Sinzinger, Lindsay Brammen
Nephrography having been introduced more than 60 years ago still now is one of the most frequently used and informative procedures in Nuclear Medicine. Although being considered a well standardized method, a worldwide study in 34 centers in 21 countries revealed that determination of split kidney function shows unacceptable high variation, particularly in patients with a relative kidney function below 30%. Furthermore, kidney depth usually is not considered. The calculation of kidney depth by various formulas available, each claiming to be more predictive, is different in races and does not allow individual information, which particularly in patients with a diseased kidney may become unreliable...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29324920/technetium-99m-dimercaptosuccinic-acid-renal-scintigraphy-can-guide-clinical-management-in-congenital-hydronephrosis
#3
Biljana Bazić-Đorović, Marija Radulović, Marija Šišić, Ljiljana Jauković, Sanja Dugonjić, Dragan Pucar, Zoran Janković, Slobodanka Beatović, Milica Janković, Zoran Krstić, Boris Ajdinović
OBJECTIVE: The purpose of this study was to evaluate damage of the kidney with technetium-99m-dimercaptosuccinic acid (99mTc-DMSA) scintigraphy in children with congenital hydronephrosis (CH) and the influence of other postnatal associated diagnoses on abnormal 99mTc-DMSA findings. SUBJECTS AND METHODS: 99mTc-DMSA scintigraphy in 54 children (17 girls and 37 boys), aged from 2 months to 5 years (median 11 months) with 66 congenital hydronephrotic renal units (RU) (42 unilateral hydronephrosis-29 boys and 13 girls; 12 bilateral hydronephrosis-8 boys and 4 girls) was performed...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29319136/the-use-of-99mtc-phytate-for-assessment-the-protective-effect-of-vitamin-e-against-hepatotoxicity-induced-by-methotrexat-in-rat
#4
Hossein Amirfakhrian, Seyed Mohammad Abedi, Hossein Sadeghi, Soheil Azizi, Seyed Jalal Hosseinimehr
In this study, we investigated the protective effect of vitamin E against methotrexate (MTX)-induced hepatotoxicity by quantitative liver 99mTc-phytate uptake and liver imaging and to compare its effect with histopathology in rat. Rats were divided into five groups as control, solvent, Vit E (100 mg/kg), MTX (20 mg/kg), Vit E + MTX and. Vit E was intraperitoneally administrated for 17 days before MTX injection and continued for 4 days. 99mTc-phytate was injected through the tail of rats after the drug administration...
January 10, 2018: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/29298960/simulation-study-of-the-second-generation-mr-compatible-spect-system-based-on-the-inverted-compound-eye-gamma-camera-design
#5
Xiaochun Lai, Ling-Jian Meng
In this paper, we presented the simulation studies for the second-generation MRI compatible SPECT system, MRC-SPECT-II, based on an inverted compound eye (ICE) gamma camera concept. The MRC-SPECT-II system consisted of a total of 1,536 independent micro-pinhole-camera-elements (MCEs) distributed in a ring with an inner diameter of 6 cm. This system provided a FOV of 1 cm diameter and a peak geometrical efficiency of approximately 1.3% (as compared to the typical levels of 0.1%-0.01% found in modern pre-clinical SPECT instrumentations) while maintaining a sub-500 μm spatial resolution...
January 4, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29291444/an-improved-99mtc-hynic-ser-3-ltvspwy-peptide-with-edda-tricine-as-co-ligands-for-targeting-and-imaging-of-her2-overexpression-tumor
#6
Fatemeh Khodadust, Sajjad Ahmadpour, Nazan Aligholikhamseh, Seyed Mohammad Abedi, Seyed Jalal Hosseinimehr
Overexpression of human epidermal receptor 2 (HER2) has given the opportunity for targeting and delivering of imaging radiotracers. The aim of this study was to evaluate the 99mTc-HYNIC-(EDDA/tricine)-(Ser)3-LTVSPWY peptide for tumor targeting and imaging of tumor with overexpression of HER2. The HYNIC-(Ser)3-LTVSPWY was labeled with 99mTc in presence of EDDA/tricine mixture as co-ligands. The in vitro and in vivo studies of this radiolabeled peptide were performed for cellular specific binding and tumor targeting...
December 13, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29278582/computer-assisted-surgery-virtual-and-augmented-reality-displays-for-navigation-during-urological-interventions
#7
Matthias N van Oosterom, Henk G van der Poel, Nassir Navab, Cornelis J H van de Velde, Fijs W B van Leeuwen
PURPOSE OF REVIEW: To provide an overview of the developments made for virtual- and augmented-reality navigation procedures in urological interventions/surgery. RECENT FINDINGS: Navigation efforts have demonstrated potential in the field of urology by supporting guidance for various disorders. The navigation approaches differ between the individual indications, but seem interchangeable to a certain extent. An increasing number of pre- and intra-operative imaging modalities has been used to create detailed surgical roadmaps, namely: (cone-beam) computed tomography, MRI, ultrasound, and single-photon emission computed tomography...
December 22, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/29249274/evaluation-of-the-diagnostic-value-of-preoperative-sentinel-lymph-node-sln-imaging-in-penile-carcinoma-patients-without-palpable-inguinal-lymph-nodes-via-single-photon-emission-computed-tomography-computed-tomography-spect-ct-as-compared-to-planar-scintigraphy
#8
Carsten Maik Naumann, Christian Colberg, Michael Jüptner, Marlies Marx, Yi Zhao, Ping Jiang, Moritz Franz Hamann, Klaus-Peter Jünemann, Maaz Zuhayra, Ulf Lützen
BACKGROUND: Sentinel lymph node (SLN) biopsy represents a well-established diagnostic tool for the assessment of lymphatic metastasis. Correct pre- and intraoperative visualization of SLN is of the utmost importance to ensure the safety and feasibility of the procedure. Aim of this study was to evaluate the diagnostic value of preoperative SLN imaging via single photon emission computed tomography/computed tomography (SPECT/CT) and planar scintigraphy in patients with penile carcinoma with nonpalpable inguinal lymph nodes...
December 14, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29236220/automatic-lung-segmentation-in-functional-spect-images-using-active-shape-models-trained-on-reference-lung-shapes-from-ct
#9
Grigorios-Aris Cheimariotis, Mariam Al-Mashat, Kostas Haris, Anthony H Aletras, Jonas Jögi, Marika Bajc, Nicolaos Maglaveras, Einar Heiberg
OBJECTIVE: Image segmentation is an essential step in quantifying the extent of reduced or absent lung function. The aim of this study is to develop and validate a new tool for automatic segmentation of lungs in ventilation and perfusion SPECT images and compare automatic and manual SPECT lung segmentations with reference computed tomography (CT) volumes. METHODS: A total of 77 subjects (69 patients with obstructive lung disease, and 8 subjects without apparent perfusion of ventilation loss) performed low-dose CT followed by ventilation/perfusion (V/P) SPECT examination in a hybrid gamma camera system...
December 13, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29230656/development-of-gate-monte-carlo-simulation-for-a-csi-pixelated-gamma-camera-dedicated-to-high-resolution-animal-spect
#10
Payvand Taherparvar, Alireza Sadremomtaz
GATE is currently considered in scintigraphic imaging as a powerful tool to develop, design and optimize nuclear medicine modalities. This paper describes the GATE simulation of a pixelated gamma camera which is dedicated to high resolution of small animals imaging. It consists of a CsI(Na) crystal array coupled to position sensitive photomultiplier tube. The simulation model includes photon tracking through low energy high resolution hexagonal parallel holes collimator, CsI(Na) pixelated crystal, back-compartment, and camera shielding...
December 11, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/29223390/lymphatic-drainage-from-renal-tumors-in-vivo-a-prospective-sentinel-node-study-using-spect-ct-imaging
#11
Teele Kuusk, Roderick De Bruijn, Oscar Brouwer R, Jeroen De Jong, Maarten Donswijk, Nikolaos Grivas, Kees Hendricksen, Simon Horenblas, Warner Prevoo, Olmos A Renato Valdés, Poel G Henk Van Der, Rhijn Wg Bas Van, Esther Wit M, Axel Bex
PURPOSE: Lymphatic drainage from renal tumors is unpredictable and in vivo drainage studies of primary lymphatic landing sites may reveal the variability and dynamics of lymphatic connections. The purpose of this study was to investigate the lymphatic drainage pattern from renal tumors in vivo with SPECT/CT imaging after intra-tumoral radiotracer injection. MATERIALS AND METHODS: We conducted a phase II prospective single-arm study to investigate the distribution of SNs from renal tumors on SPECT/CT imaging...
December 6, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29209953/diagnostic-value-of-99mtc-ethambutol-scintigraphy-in-tuberculosis-compared-to-microbiological-and-histopathological-tests
#12
A H S Kartamihardja, Y Kurniawati, R Gunawan
OBJECTIVE: Tuberculosis (TB) still remains the world's endemic infection. TB affects the lungs and any part of the body other than the lung. The diagnosis of TB has not changed much over the decades. Ethambutol is one of the first line treatments for TB. It can be labeled using 99mTc. 99mTc-ethambutol will be accumulated in the site of TB lesion and can be imaged using gamma camera. The aim of this study was to evaluate the diagnostic value of 99mTc-ethambutol scintigraphy in detecting and localizing of TB...
December 5, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29201463/complex-monitoring-of-biochemical-and-radionuclide-parameters-in-patients-with-metastatic-renal-cell-carcinoma-during-immunotherapy
#13
M S Sayapina, S G Averinova, T V Zacharova, A V Kashkadaeva, S V Shiryaev, M V Poluectova, O A Vorob'eva
Study Objective: To study the effectiveness of complex monitoring of the kidney function, based on biochemical and radionuclide methods in patients with metastatic renal cell carcinoma (mRCC). Materials and Methods: 41 mRCC patients after nephrectomy received nivolumab (n = 23) and interferon-α (n = 18) from 2015 to 2017. At baseline and 2 months after, all patients underwent blood chemistry, urinalysis, Rehberg test, and ELISA to determine serum levels of IL-17A, TGF-β, and erythropoietin...
2017: International Journal of Nephrology
https://www.readbyqxmd.com/read/29189207/psf-reconstruction-for-compton-based-prompt-gamma-imaging
#14
Meei-Ling Jan, Ming-Wei Lee, Hsuan-Ming Huang
Compton-based prompt gamma (PG) imaging has been proposed for in vivo range verification in proton therapy. However, several factors degrade the image quality of PGs, some of which are due to inherent properties of a Compton camera such as spatial resolution and energy resolution. Moreover, Compton-based PG imaging has a spatially variant resolution loss. In this study, we investigate the performance of the list-mode ordered subset expectation maximization algorithm with a shift-variant point spread function model (LM-OSEM-SV-PSF)...
November 30, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29151546/-a-comparison-of-planar-sensitivity-and-spatial-resolution-among-different-collimators-and-energy-windows-on-223-ra-imaging
#15
Takuro Umeda, Noriaki Miyaji, Shuto Nakazawa, Kenta Miwa, Kei Wagatsuma, Kazuki Motegi, Tomohiro Takiguchi, Mitsuru Koizumi
OBJECTIVE: The present study aimed to reveal the influence of combination of different collimators and energy windows on the planar sensitivity and the spatial resolution during experimental (223)Ra imaging, and to determine optimal imaging parameters. METHODS: A vial type source containing (223)Ra solution (4.55 MBq / 5.6 ml) was placed in the air at 100 mm away from the collimator surface. Planar images were acquired with LEHR, LMEGP, ELEGP and MEGP collimators on two dual-head gamma cameras (Symbia intevo (Siemens) and Infinia 3 (GE))...
2017: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/29142346/conjugation-of-antibodies-with-radiogold-nanoparticles-as-an-effector-targeting-agents-in-radiobioconjugate-cancer-therapy-optimized-labeling-and-biodistribution-results
#16
Pankaj Garg, Daya Kishore Hazra
Purpose of the Study: Drug accessibility to the tumor cells is an important area of concern with an anticipation of increasing the efficacy of the drug to be delivered to a specific site. The biogenesis of gold nanoparticles using plant-mediated phytochemical extracts and their possible linkage to cancer antibodies with an aim at delivering the conjugate specifically to the tumor-associated antigen is the basic objective of the research. Materials and Methodology: Radiolabeling of antibodies with gold nanoparticles was carried out by a protocol, and the labeling extent of antibodies was compared with that of a radiogold solution to ordinary particulate size (AuNO-Ab)...
October 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29142344/investigating-the-role-of-global-histogram-equalization-technique-for-99m-technetium-methylene-diphosphonate-bone-scan-image-enhancement
#17
Anil Kumar Pandey, Param Dev Sharma, Pankaj Dheer, Girish Kumar Parida, Harish Goyal, Chetan Patel, Chandrashekhar Bal, Rakesh Kumar
Purpose of the Study: (99m)Technetium-methylene diphosphonate ((99m)Tc-MDP) bone scan images have limited number of counts per pixel, and hence, they have inferior image quality compared to X-rays. Theoretically, global histogram equalization (GHE) technique can improve the contrast of a given image though practical benefits of doing so have only limited acceptance. In this study, we have investigated the effect of GHE technique for (99m)Tc-MDP-bone scan images. Materials and Methods: A set of 89 low contrast (99m)Tc-MDP whole-body bone scan images were included in this study...
October 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29142343/calculating-gamma-camera-uniformity-parameters-beyond-the-vendor-specific-protocol
#18
Anil Kumar Pandey, Param Dev Sharma, Jay Prakash Kumar, Kartik Saroha, Chetan Patel, Chandra Sekhar Bal, Rakesh Kumar
Objectives: The aim of this study was to develop and verify a personal computer-based software tool for calculating uniformity indices of gamma camera. Materials and Methods: The program was developed in MATLAB R2013b under Microsoft Windows operating system. Noise-less digital phantoms with known uniformity parameters were used to verify the accuracy of the program. Two hundred and forty-four Co-57 flood source images were acquired on Symbia T6 and Discovery nuclear medicine/computed tomography 670...
October 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29127242/gamma-camera-based-method-for-131-i-capsule-counting-an-alternate-method-to-uptake-probe-method
#19
Biju K Menon, Awasare S Uday, Baghel N Singh
The main objective of this study was to check the validity of using gamma camera as an alternate method to thyroid uptake probe, for counting 25uCi (0.925 MBq) and 50uCi (1.85 MBq) (131)I capsules before administration to thyroid patients. Methods: - 10 sets each of 25uCi (0.925 MBq) and 50uCi (1.85 MBq) (131)I capsules received from Board Of Radiation and Isotope Technology, Department Of Atomic Energy, India (BRIT, DAE) have been counted individually using thyroid uptake probe for 10 seconds following institutional protocol and also by keeping individual capsule of a set with 8cm gap between each of them ...
November 10, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/29125780/segmentation-of-whole-body-images-into-two-compartments-in-model-for-bone-marrow-dosimetry-increases-the-correlation-with-hematological-response-in-177-lu-dotatate-treatments
#20
Linn Hagmarker, Johanna Svensson, Tobias Rydén, Peter Gjertsson, Peter Bernhardt
BACKGROUND: In (177)Lu-DOTATATE treatments, bone marrow (BM) is one of the most important organs at risk. The authors previously developed an image-based two-compartment method for BM dosimetry, showing a significant correlation between absorbed dose to BM and hematological toxicity in (177)Lu-DOTATATE treatments. In the present study, they aimed to further evaluate this BM dosimetry method by finding optimal settings for dividing the whole body into two compartments; in terms of minimizing the coefficient of variation (CV) for the individual absorbed doses and studying its correlation to the BM response...
November 2017: Cancer Biotherapy & Radiopharmaceuticals
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