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https://www.readbyqxmd.com/read/28429391/technical-note-direct-measurement-of-continuous-tmr-data-with-a-1d-tank-and-automated-couch-movements
#1
Nels C Knutson, Matthew C Schmidt, Matthew D Belley, Ngoc Nguyen, H Harold Li, Erno Sajo, Michael Price
PURPOSE: Real-time dynamic control of the linear accelerator, couch, and imaging parameters during radiation delivery was investigated as a novel technique for acquiring tissue maximum ratio (TMR) data. METHODS: TrueBeam Developer Mode (Varian Medical Systems, Palo Alto, CA) was used to control the linear accelerator using the Extensible Markup Language (XML). A single XML file was used to dynamically manipulate the machine, couch, and imaging parameters during radiation delivery...
April 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/28414454/novel-soil-profile-sensing-to-monitor-organic-c-stocks-and-condition
#2
Raphael A Viscarra Rossel, Craig R Lobsey, Chris Sharman, Paul Flick, Gordon McLachlan
Soil information is needed for environmental monitoring to address current concerns over food, water and energy securities, land degradation and climate change. We developed the {\sc Soil Condition ANalyses System (SCANS)} to help address these needs. It integrates an automated soil core sensing system (CSS) with statistical analytics and modelling to enable the characterisation of soil at fine depth resolutions and across landscapes. The CSS's sensors include a gamma-ray densitometer to measure bulk density, digital cameras to image the measured soil and a visible--near infrared (vis--NIR) spectrometer to measure iron oxides and clay mineralogy...
April 17, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28408699/a-novel-cerium-141-based-flood-field-uniformity-phantom-assessment-of-its-suitability-to-perform-daily-uniformity-test-in-a-clinical-nuclear-medicine-department
#3
Ashish Kumar Jha, Sneha Mithun, Manoj H Chauhan, Nilendu C Purandare, Sneha Shah, Archi Agrawal, Sanjay Kumar Saxena, Ashutosh Dash, Venkatesh Rangarajan
Daily quality control of a gamma camera is of utmost importance to assess the suitability of the camera for clinical use. Aim of our study is to find out the relevance of indigenously developed (141)Ce -flood field phantom in daily quality control of gamma camera. Material & Method: Uniformity tests were performed by using (141)Ce-flood field phantom and commercially available (57)Co -flood field phantom, and results compared. Result: The average percentage integral uniformity obtained by (141)Ce -flood field phantom and (57)Co -flood field phantom were 3...
April 13, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28408530/alternative-means-of-estimating-131-i-maximum-permissible-activity-to-treat-thyroid-cancer
#4
Kenneth J Nichols, William Robeson, Miyuki Yoshida-Hay, Pat B Zanzonico, Fritzgerald C Leveque, Kuldeep K Bhargava, Gene G Tronco, Christopher J Palestro
To protect bone marrow from over-irradiation, maximum permissible activity (MPA) of iodine-131 ((131)I) to treat thyroid cancer is that which limits absorbed dose to blood (as a surrogate of marrow) to < 200 cGy. The conventional approach (Method-1) requires repeated gamma-camera whole-body measurements along with blood samples. We sought to determine whether reliable MPA values can be obtained by simplified procedures. Methods: Data acquired over multiple time points were examined retrospectively for 65 thyroid cancer patients, referred to determine (131)I uptake and MPA for initial treatment following thyroidectomy (N = 39), including 17 patients with compromised renal function and 22 patients with known (N = 16) or suspected (N = 6) metastases...
April 13, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28380420/imaging-and-targeted-therapy-of-pancreatic-ductal-adenocarcinoma-using-the-theranostic-sodium-iodide-symporter-nis-gene
#5
Kathrin A Schmohl, Aayush Gupta, Geoffrey K Grünwald, Marija Trajkovic-Arsic, Kathrin Klutz, Rickmer Braren, Markus Schwaiger, Peter J Nelson, Manfred Ogris, Ernst Wagner, Jens T Siveke, Christine Spitzweg
The theranostic sodium iodide symporter (NIS) gene allows detailed molecular imaging of transgene expression and application of therapeutic radionuclides. As a crucial step towards clinical application, we investigated tumor specificity and transfection efficiency of epidermal growth factor receptor (EGFR)-targeted polyplexes as systemic NIS gene delivery vehicles in an advanced genetically engineered mouse model of pancreatic ductal adenocarcinoma (PDAC) that closely reflects human disease. PDAC was induced in mice by pancreas-specific activation of constitutively active KrasG12D and deletion of Trp53...
March 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28361477/effect-of-patient-positioning-on-the-evaluation-of-myocardial-perfusion-spect
#6
Bertalan Kracskó, Sándor Barna, Orsolya Sántha, Anett Kiss, József Varga, Attila Forgács, Ildikó Garai
BACKGROUND: ECG-gated SPECT myocardial perfusion imaging is usually acquired in supine position. However, some patients are not comfortable in this position for a variety of personal or medical reasons. Our aim was to investigate the effect of patient positioning on quantitative SPECT imaging results using normal supine database. METHODS: 55 patients (mean age 58.5 ± 8.3 years) were enrolled in this prospective study. Each patient had a pair of ECG-gated stress SPECT myocardial perfusion images acquired on two gamma cameras: one in supine position and the other in upright sitting position...
March 30, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28357719/bubble-size-distribution-in-a-laboratory-scale-electroflotation-study
#7
Raquibul Alam, Julie Q Shang, Adnan Hossain Khan
The performance of electroflotation (EF) is strongly influenced by the size of O2 and H2 bubbles. Therefore, in this study, the bubble sizes are measured in a lab-scale EF cell using a high-speed camera. The mean bubble size is found to vary in the range of 32.7-68.6 μm under different operating conditions. This study shows that the electrode material, current density, water pH, ionic strength, and frother (Tennafroth 250) concentration are important factors in controlling the bubble size. Furthermore, four mathematical distributions (normal, log-normal, Weibull, and gamma distributions) are fitted to the experimental data, among which the log-normal distribution is found to be the best fit based on the lower Anderson-Darling (AD) value...
April 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28356664/comparison-of-serum-creatinine-based-estimating-equations-with-gates-protocol-for-predicting-glomerular-filtration-rate-in-indian-population
#8
A V Mulay, S M Gokhale
In clinical practice, serum creatinine-based predicting equations and Gates protocol based on gamma camera imaging of kidneys after injection of Tc99m-diethylenetriaminepentaacetic acid (DTPA) are commonly used to assess glomerular filtration rate (GFR). Comparison of these methods, especially the chronic kidney disease-epidemiology collaboration (CKD-EPI) equation with gold standard method of assessment of GFR by plasma clearance of Tc-99mDTPA is not well-studied in Indian population. We conducted this study to compare GFR estimation by gamma camera-based Gates protocol and serum creatinine-based predicting equations with GFR measured by plasma clearance of Tc-99mDTPA...
March 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/28343906/comparative-analysis-of-iterative-reconstruction-algorithms-with-resolution-recovery-and-new-solid-state-cameras-dedicated-to-myocardial-perfusion-imaging
#9
Marco Brambilla, Michela Lecchi, Roberta Matheoud, Lucia Leva, Giovanni Lucignani, Claudio Marcassa, Orazio Zoccarato
New technologies are available in myocardial perfusion imaging. They include new software that recovers image resolution and limits image noise, multifocal collimators and dedicated cardiac cameras in which solid-state detectors are used and all available detectors are constrained to imaging just the cardiac field of view. These innovations resulted in shortened study times or reduced administered activity to patients, while preserving image quality. Many single center and some multicenter studies have been published during the introduction of these innovations in the clinical practice...
March 23, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28342380/optimization-of-the-compton-camera-for-measuring-prompt-gamma-rays-in-boron-neutron-capture-therapy
#10
Chun-Hui Gong, Xiao-Bin Tang, Di-Yun Shu, Hai-Yan Yu, Chang-Ran Geng
Optimization of the Compton camera for measuring prompt gamma rays (0.478MeV) emitted during boron neutron capture therapy (BNCT) was performed with Geant4. The parameters of the Compton camera were determined as follows: 3cm thick - 10cm wide scatter detector (Silicon), 10cm thick - 10cm wide absorber detector (Germanium), and 1cm distance between the scatter and absorber detectors. For a typical brain tumor treatment, the overall detection efficiency of the optimized Compton camera was approximately 0.1425% using the Snyder's head phantom with a sphere tumor (4cm diameter and ~1cm depth)...
March 19, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28325351/flexible-fiber-optic-high-speed-imaging-of-vocal-fold-vibration-a-preliminary-report
#11
Peak Woo, Peter Baxter
OBJECTIVE: High-speed video (HSV) imaging of vocal fold vibration has been possible only through the rigid endoscope. This study reports that a fiberscope-based high-speed imaging system may allow HSV imaging of naturalistic voicing. MATERIALS AND METHODS: Twenty-two subjects were recorded using a commercially available black and white high-speed camera (Photron Motion Tools, 256 × 120 pixel, 2000 frames per second, 8 second acquisition time). The camera gain is set to +6 db...
March 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28315905/breast-specific-gamma-camera-imaging-with-99m-tc-mibi-has-better-diagnostic-performance-than-magnetic-resonance-imaging-in-breast-cancer-patients-a-meta-analysis
#12
Aimi Zhang, Panli Li, Qiufang Liu, Shaoli Song
OBJECTIVE: This study aimed to evaluate the diagnostic role of breast-specific gamma camera imaging (BSGI) with technetium-99m-methoxy isobutyl isonitrile ((99m)Tc-MIBI) and magnetic resonance imaging (MRI) in patients with breast cancer through a meta-analysis. METHODS: Three reviewers searched articles published in medical journals before June 2016 in MEDLINE, EMBASE and Springer Databases; the references listed in original articles were also retrieved. We used the quality assessment of diagnostic accuracy studies (QUADAS) tool to assess the quality of the included studies...
January 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28315122/cardio-oncology-the-nuclear-option
#13
REVIEW
Jorge A Alvarez, Raymond R Russell
PURPOSE OF REVIEW: Cardio-oncology focuses increased effort to decrease cancer treatment-related cardiotoxicity while continuing to improve outcomes. We sought to synthesize the latest in nuclear cardiology as it pertains to the assessment of left ventricular function in preventative guidelines and comparison to other modalities, novel molecular markers of pre-clinical cardiotoxicity, and its role in cardiac amyloid diagnosis. RECENT FINDINGS: Planar ERNA (equilibrium radionuclide angiocardiography) provides a reliable and proven means of monitoring and preventing anthracycline cardiotoxicity, and SPECT ERNA using solid-state gamma cameras may provide reproducible assessments of left ventricular function with reduced radiation exposure...
April 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28282957/a-multimodality-hybrid-gamma-optical-camera-for-intraoperative-imaging
#14
John E Lees, Sarah L Bugby, Mohammed S Alqahtani, Layal K Jambi, Numan S Dawood, William R McKnight, Aik H Ng, Alan C Perkins
The development of low profile gamma-ray detectors has encouraged the production of small field of view (SFOV) hand-held imaging devices for use at the patient bedside and in operating theatres. Early development of these SFOV cameras was focussed on a single modality-gamma ray imaging. Recently, a hybrid system-gamma plus optical imaging-has been developed. This combination of optical and gamma cameras enables high spatial resolution multi-modal imaging, giving a superimposed scintigraphic and optical image...
March 9, 2017: Sensors
https://www.readbyqxmd.com/read/28275975/design-and-performance-evaluation-of-a-new-high-energy-parallel-hole-collimator-for-radioiodine-planar-imaging-by-gamma-cameras-monte-carlo-simulation-study
#15
Vahid Moslemi, Mansour Ashoor
OBJECTIVE: In addition to the trade-off between resolution and sensitivity which is a common problem among all types of parallel hole collimators (PCs), obtained images by high energy PCs (HEPCs) suffer from hole-pattern artifact (HPA) due to further septa thickness. In this study, a new design on the collimator has been proposed to improve the trade-off between resolution and sensitivity and to eliminate the HPA. METHODS: A novel PC, namely high energy extended PC (HEEPC), is proposed and is compared to HEPCs...
May 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28265641/-nuclear-medicine-in-germany-updated-key-data-and-trends-from-official-statistics
#16
Dirk Hellwig, Jörg Marienhagen, Karin Menhart, Jirka Grosse
AIM: Updated presentation of the spectrum of nuclear medicine in-vivo examinations and therapies from officially available statistics on out-patient and in-patient care as well as trends of structural data on nuclear medicine in Germany. METHODS: Data from the German Federal Health Monitoring, from the frequency statistics of the statutory health insurance for out-patients and from the German Medical Association were used and supplemented by data from selective literature searches...
March 7, 2017: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/28259605/hands-on-physics-education-of-residents-in-diagnostic-radiology
#17
Jie Zhang, Peter A Hardy, David J DiSantis, M Elizabeth Oates
RATIONALE AND OBJECTIVES: The American Board of Radiology Core Examination integrates assessment of physics knowledge into its overall testing of clinical radiology, with an emphasis on understanding image quality and artifacts, radiation dose, and patient safety for each modality or subspecialty organ system. Accordingly, achieving a holistic approach to physics education of radiology residents is a huge challenge. The traditional teaching of radiological physics-simply through didactic lectures-was not designed for such a holistic approach...
March 1, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28192280/iterative-reconstruction-of-sipm-light-response-functions-in-a-square-shaped-compact-gamma-camera
#18
A Morozov, F Alves, J Marcos, R Martins, L Pereira, V Solovov, V Chepel
Compact gamma cameras with a square-shaped monolithic scintillator crystal and an array of silicon photomultipliers (SiPMs) are actively being developed for applications in areas such as small animal imaging, cancer diagnostics and radiotracer guided surgery. Statistical methods of position reconstruction, which are potentially superior to the traditional centroid method, require accurate knowledge of the spatial response of each photomultiplier. Using both Monte Carlo simulations and experimental data obtained with a camera prototype, we show that the spatial response of all photomultipliers (light response functions) can be parameterized with axially symmetric functions obtained iteratively from flood field irradiation data...
February 13, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28155883/first-on-site-true-gamma-ray-imaging-spectroscopy-of-contamination-near-fukushima-plant
#19
Dai Tomono, Tetsuya Mizumoto, Atsushi Takada, Shotaro Komura, Yoshihiro Matsuoka, Yoshitaka Mizumura, Makoto Oda, Toru Tanimori
We have developed an Electron Tracking Compton Camera (ETCC), which provides a well-defined Point Spread Function (PSF) by reconstructing a direction of each gamma as a point and realizes simultaneous measurement of brightness and spectrum of MeV gamma-rays for the first time. Here, we present the results of our on-site pilot gamma-imaging-spectroscopy with ETCC at three contaminated locations in the vicinity of the Fukushima Daiichi Nuclear Power Plants in Japan in 2014. The obtained distribution of brightness (or emissivity) with remote-sensing observations is unambiguously converted into the dose distribution...
February 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28155870/establishment-of-imaging-spectroscopy-of-nuclear-gamma-rays-based-on-geometrical-optics
#20
Toru Tanimori, Yoshitaka Mizumura, Atsushi Takada, Shohei Miyamoto, Taito Takemura, Tetsuro Kishimoto, Shotaro Komura, Hidetoshi Kubo, Shunsuke Kurosawa, Yoshihiro Matsuoka, Kentaro Miuchi, Tetsuya Mizumoto, Yuma Nakamasu, Kiseki Nakamura, Joseph D Parker, Tatsuya Sawano, Shinya Sonoda, Dai Tomono, Kei Yoshikawa
Since the discovery of nuclear gamma-rays, its imaging has been limited to pseudo imaging, such as Compton Camera (CC) and coded mask. Pseudo imaging does not keep physical information (intensity, or brightness in Optics) along a ray, and thus is capable of no more than qualitative imaging of bright objects. To attain quantitative imaging, cameras that realize geometrical optics is essential, which would be, for nuclear MeV gammas, only possible via complete reconstruction of the Compton process. Recently we have revealed that "Electron Tracking Compton Camera" (ETCC) provides a well-defined Point Spread Function (PSF)...
February 3, 2017: Scientific Reports
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