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https://www.readbyqxmd.com/read/28091980/comparison-of-tc-99m-maraciclatide-and-tc-99m-sestamibi-molecular-breast-imaging-in-patients-with-suspected-breast-cancer
#1
Michael K O'Connor, Melissa M B Morrow, Katie N Hunt, Judy C Boughey, Dietlind L Wahner-Roedler, Amy Lynn Conners, Deborah J Rhodes, Carrie B Hruska
BACKGROUND: Molecular breast imaging (MBI) performed with (99m)Tc sestamibi has been shown to be a valuable technique for the detection of breast cancer. Alternative radiotracers such as (99m)Tc maraciclatide may offer improved uptake in breast lesions. The purpose of this study was to compare relative performance of (99m)Tc sestamibi and (99m)Tc maraciclatide in patients with suspected breast cancer, using a high-resolution dedicated gamma camera for MBI. Women with breast lesions suspicious for malignancy were recruited to undergo two MBI examinations-one with (99m)Tc sestamibi and one with (99m)Tc maraciclatide...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28072581/-131-i-activity-quantification-of-gamma-camera-planar-images
#2
Raquel Barquero, Hugo P Garcia, Monica G Incio, Pablo Minguez, Alexander Cardenas, Daniel Martínez, Michael Lassmann
A procedure to estimate the activity in target tissues in patients during the therapeutic administration of (131)I radiopharmaceutical treatment for thyroid conditions (hyperthyroidism and differentiated thyroid cancer) using a gamma camera (GC) with a high energy (HE) collimator, is proposed. Planar images are acquired for lesions of different sizes r, and at different distances d, in two HE GC systems. Defining a region of interest (ROI) on the image of size r, total counts n g are measured. Sensitivity S (cps MBq(-1)) in each acquisition is estimated as the product of the geometric G and the intrinsic efficiency η 0...
February 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28048841/mo-fg-campus-jep1-02-proton-range-verification-of-scanned-pencil-beams-using-prompt-gamma-imaging
#3
Y Xie, E Bentefour, G Janssens, J Smeets, D Dolney, L Yin, L Hotoiu, F Vander Stappen, S Avery, F O'Grady, D Prieels, J McDonough, T Solberg, A Lin, B Teo
PURPOSE: Prompt gammas are emitted along the proton beam path and have an emission profile correlated with the depth dose profile. In this study, the accuracy of in-vivo proton range verification using a 1-D prompt gamma camera is assessed. METHODS: The 1-D camera is comprised of a tungsten slit collimator positioned in front of a linear array of LYSO scintillating crystals coupled to silicon photomultipliers. The imaged gamma profiles of individual pencil beam spots and energy layers were analyzed by determining the relative shifts from the expected gamma profiles based on analytic prediction or reference measurements...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048840/su-f-j-208-prompt-gamma-imaging-based-prediction-of-bragg-peak-position-for-realistic-treatment-error-scenarios
#4
Y Xing, B Macq, G Janssens, L Bondar
PURPOSE: To quantify the accuracy in predicting the Bragg peak position using simulated in-room measurements of prompt gamma (PG) emissions for realistic treatment error scenarios that combine several sources of errors. METHODS: Prompt gamma measurements by a knife-edge slit camera were simulated using an experimentally validated analytical simulation tool. Simulations were performed, for 143 treatment error scenarios, on an anthropomorphic phantom and a pencil beam scanning plan for nasal cavity...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048785/su-f-j-08-quantitative-spect-imaging-of-ra-223-in-a-phantom
#5
J Yue, R Hobbs, G Sgouros, E Frey
PURPOSE: Ra-223 therapy of prostate cancer bone metastases is being used to treat patients routinely. However, the absorbed dose distribution at the macroscopic and microscopic scales remains elusive, due to the inability to image the small activities injected. Accurate activity quantification through imaging is essential to calculate the absorbed dose in organs and sub-units in radiopharmaceutical therapy, enabling personalized absorbed dose-based treatment planning methodologies and more effective and optimal treatments...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048450/su-g-iep4-02-application-of-changs-attenuation-correction-technique-for-spect-partial-angle-acquisition-of-jaszczak-phantom
#6
K Saha, J Barbarits, R Humenik, J Johnson, B Murray, S Hoyt
PURPOSE: Chang's mathematical formulation is a common method of attenuation correction applied on reconstructed Jaszczak phantom images. Though Chang's attenuation correction method has been used for 360° angle acquisition, its applicability for 180° angle acquisition remains a question with one vendor's camera software producing artifacts. The objective of this work is to ensure that Chang's attenuation correction technique can be applied for reconstructed Jaszczak phantom images acquired in both 360° and 180° mode...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048363/su-f-t-518-development-and-characterization-of-a-gated-treatment-system-implemented-with-an-in-house-optical-tracking-system-and-the-elekta-response-interface
#7
B Barraclough, J Park, F Li, B Lu, J Li, C Liu, G Yan
PURPOSE: To report the development and characterization of the first in-house gating system implemented with an optical tracking system (OTS) and the Elekta Response™ interface. METHODS: The Response™ connects a patient tracking system with a linac, enabling the tracking system to control radiation delivery. The developed system uses an in-house OTS to monitor patient breathing. The OTS consists of two infrared-based cameras, tracking markers affixed on patient...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048215/mo-ab-206-00-nuclear-medicine-physics-and-testing
#8
Sharon White
: This education session will cover the physics and operation principles of gamma cameras and PET scanners. The first talk will focus on PET imaging. An overview of the principles of PET imaging will be provided, including positron decay physics, and the transition from 2D to 3D imaging. More recent advances in hardware and software will be discussed, such as time-of-flight imaging, and improvements in reconstruction algorithms that provide for options such as depth-of-interaction corrections...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048122/su-f-j-182-investigation-of-systems-for-improved-accuracy-in-clinical-y-90-percent-delivered-calculations
#9
R McBeth, D Elder, A Kesner
PURPOSE: Y-90 Selective Internal Radiation Therapy (SIRT) is used to treat liver tumors, and by nature has variability in the percent of the intended dose that is actually delivered. To determine the quality of the administration, pre and post activity measurements are taken, and used to infer percent delivered. Vendor specifications indicate the use of an ion chamber to take these measurements. In our work, we investigated the accuracy of ion chambers, and compared them to other detector systems...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047972/tu-fg-brb-05-a-3-dimensional-prompt-gamma-imaging-system-for-range-verification-in-proton-radiotherapy
#10
E Draeger, H Chen, D Mackin, S Peterson, S Avery, S Beddar, J Polf
PURPOSE: To report on the initial developments of a clinical 3-dimensional (3D) prompt gamma (PG) imaging system for proton radiotherapy range verification. METHODS: The new imaging system under development consists of a prototype Compton camera to measure PG emission during proton beam irradiation and software to reconstruct, display, and analyze 3D images of the PG emission. For initial test of the system, PGs were measured with a prototype CC during a 200 cGy dose delivery with clinical proton pencil beams (ranging from 100 MeV - 200 MeV) to a water phantom...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047625/su-f-j-129-verification-of-geometric-and-dosimetric-accuracy-of-respiratory-management-systems-using-homemade-phantom
#11
E Goksel, H Kucucuk, O Senkesen, E Tezcanli
PURPOSE: Different placements of Infrared Cameras (IRC) in CT and treatment rooms can cause gating window level (GWL) variations leading to differences between GWL used for planning and treatments. Although, Varian Clinac DHX-OBI sytem and CT are equipped with the same kind of IRC, Truebeam STx (TB) has a different type of IRC known as banana type. In this study; geometric and dosimetric accuracy of respiratory management system (RPM) for different machines were investigated with a special homemade phantom...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047563/mo-ab-206-01-pet-physics
#12
T Turkington
: This education session will cover the physics and operation principles of gamma cameras and PET scanners. The first talk will focus on PET imaging. An overview of the principles of PET imaging will be provided, including positron decay physics, and the transition from 2D to 3D imaging. More recent advances in hardware and software will be discussed, such as time-of-flight imaging, and improvements in reconstruction algorithms that provide for options such as depth-of-interaction corrections...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046963/su-g-iep4-12-performance-of-in-111-coincident-gamma-ray-counting-a-monte-carlo-simulation
#13
R Pahlka, S Kappadath, O Mawlawi
PURPOSE: The decay of In-111 results in a non-isotropic gamma-ray cascade, which is normally imaged using a gamma camera. Creating images with a gamma camera using coincident gamma-rays from In-111 has not been previously studied. Our objective was to explore the feasibility of imaging this cascade as coincidence events and to determine the optimal timing resolution and source activity using Monte Carlo simulations. METHODS: GEANT4 was used to simulate the decay of the In-111 nucleus and to model the gamma camera...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046914/mo-ab-206-02-testing-gamma-cameras-based-on-tg177-wg-report
#14
J Halama
: This education session will cover the physics and operation principles of gamma cameras and PET scanners. The first talk will focus on PET imaging. An overview of the principles of PET imaging will be provided, including positron decay physics, and the transition from 2D to 3D imaging. More recent advances in hardware and software will be discussed, such as time-of-flight imaging, and improvements in reconstruction algorithms that provide for options such as depth-of-interaction corrections...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046853/su-f-j-200-an-improved-method-for-event-selection-in-compton-camera-imaging-for-particle-therapy
#15
D Mackin, S Beddar, J Polf, S Peterson, E Draeger
PURPOSE: The uncertainty in the beam range in particle therapy limits the conformality of the dose distributions. Compton scatter cameras (CC), which measure the prompt gamma rays produced by nuclear interactions in the patient tissue, can reduce this uncertainty by producing 3D images confirming the particle beam range and dose delivery. However, the high intensity and short time windows of the particle beams limit the number of gammas detected. We attempt to address this problem by developing a method for filtering gamma ray scattering events from the background by applying the known gamma ray spectrum...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046699/su-f-j-65-prediction-of-patient-setup-errors-and-errors-in-the-calibration-curve-from-prompt-gamma-proton-range-measurements
#16
J Albert, R Labarbe, E Sterpin, J Lee, B Macq
PURPOSE: To understand the extent to which the prompt gamma camera measurements can be used to predict the residual proton range due to setup errors and errors in the calibration curve. METHODS: We generated ten variations on a default calibration curve (CC) and ten corresponding range maps (RM). Starting with the default RM, we chose a square array of N beamlets, which were then rotated by a random angle θ and shifted by a random vector s. We added a 5% distal Gaussian noise to each beamlet in order to introduce discrepancies that exist between the ranges predicted from the prompt gamma measurements and those simulated with Monte Carlo algorithms...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046621/su-f-t-287-a-preliminary-study-on-patient-specific-vmat-verification-using-a-phosphor-screen-based-geometric-qa-system-raven-qa
#17
M Lee, J Wong, K Ding, B Yi
PURPOSE: The RavenQA system (LAP Laser, Germany) is a QA device with a phosphor screen detector for performing the QA tasks of TG-142. This study tested if it is feasible to use the system for the patient specific QA of the Volumetric Modulated Arc Therapy (VMAT). METHODS: Water equivalent material (5cm) is attached to the front of the detector plate of the RavenQA for dosimetry purpose. Then the plate is attached to the gantry to synchronize the movement between the detector and the gantry...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046574/tu-h-206-01-an-automated-approach-for-identifying-geometric-distortions-in-gamma-cameras
#18
S Mann, J Nelson, E Samei
PURPOSE: To develop a clinically-deployable, automated process for detecting artifacts in routine nuclear medicine (NM) quality assurance (QA) bar phantom images. METHODS: An artifact detection algorithm was created to analyze bar phantom images as part of an ongoing QA program. A low noise, high resolution reference image was acquired from an x-ray of the bar phantom with a Philips Digital Diagnost system utilizing image stitching. NM bar images, acquired for 5 million counts over a 512×512 matrix, were registered to the template image by maximizing mutual information (MI)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046264/su-f-j-189-a-method-to-improve-the-spatial-resolution-of-prompt-gamma-based-compton-imaging-for-proton-range-verification
#19
E Draeger, D Mackin, S Peterson, H Chen, S Beddar, J Polf
PURPOSE: To test two new techniques, the distance-of-closest approach (DCA) and Compton line (CL) filters, developed as a means of improving the spatial resolution of Compton camera (CC) imaging. METHODS: Gammas emitted from (22) Na, (137) Cs, and (60) Co point sources were measured with a prototype 3-stage CC. The energy deposited and position of each interaction in each stage were recorded and used to calculate a "cone-of-origin" for each gamma that scattered twice in the CC...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28044322/simultaneous-fluoroscopic-and-nuclear-imaging-impact-of-collimator-choice-on-nuclear-image-quality
#20
Sandra van der Velden, Casper Beijst, Max A Viergever, Hugo W A M de Jong
PURPOSE: X-ray-guided oncological interventions could benefit from the availability of simultaneously acquired nuclear images during the procedure. To this end, a real-time, hybrid fluoroscopic and nuclear imaging device, consisting of an X-ray c-arm combined with gamma imaging capability, is currently being developed (Beijst C, Elschot M, Viergever MA, de Jong HW. Radiol. 2015;278:232-238). The setup comprises four gamma cameras placed adjacent to the X-ray tube. The four camera views are used to reconstruct an intermediate three-dimensional image, which is subsequently converted to a virtual nuclear projection image that overlaps with the X-ray image...
November 21, 2016: Medical Physics
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