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gamma camera

Jorge Mejia, Ana Claudia Camargo Miranda, Ana Claudia Ranucci Durante, Larissa Rolim de Oliveira, Marycel Rosa Felisa Figols de Barboza, Katerin Taboada Rosell, Daniele Pereira Jardim, Alexandre Holthausen Campos, Marilia Alves Dos Reis, Marcela Forli Catanoso, Orfa Yineth Galvis-Alonso, Francisco Romero Cabral
Objective: To present the result of upgrading a clinical gamma-camera to be used to obtain in vivo tomographic images of small animal organs, and its application to register cardiac, renal and neurological images. Methods: An updated version of the miniSPECT upgrading device was built, which is composed of mechanical, electronic and software subsystems. The device was attached to a Discovery VH (General Electric Healthcare) gamma-camera, which was retired from the clinical service and installed at the Centro de Imagem Pré-Clínica of the Hospital Israelita Albert Einstein...
July 2016: Einstein
Myoung Hyoun Kim, Chang Guhn Kim, Seul-Gi Kim, Dae-Weung Kim
The serine-aspartic acid-valine (SDV) peptide binds specifically to integrin αV β3 . In the present study, we successfully developed a TAMRA-GHEG-ECG-SDV peptide labeled with both Tc-99 m and TAMRA to target the integrin αV β3 of tumor cells; furthermore, we evaluated the diagnostic performance of Tc-99 m TAMRA-GHEG-ECG-SDV as a dual-modality imaging agent for tumor of the murine model. TAMRA-GHEG-ECG-SDV was synthesized using Fmoc solid-phase peptide synthesis. Radiolabeling of TAMRA-GHEG-ECG-SDV with Tc-99 m was done using ligand exchange methods...
October 14, 2016: Contrast Media & Molecular Imaging
Maria Georgiou, Eleftherios Fysikopoulos, Konstantinos Mikropoulos, Eirini Fragogeorgi, George Loudos
PURPOSE: Several preclinical imaging systems are commercially available, but their purchase and maintenance costs make them unaffordable for the majority of small- and medium-sized groups. Taking into account the needs of average users, we developed "γ-eye", a mouse-sized, benchtop γ-camera suitable for in vivo scintigraphic imaging. PROCEDURES: The γ-eye is based on two position-sensitive photomultiplier tubes, coupled to a CsI(Na) pixelated scintillator and a low-energy lead collimator with parallel hexagonal holes...
October 11, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
Denis Agostini, Pierre-Yves Marie, Simona Ben-Haim, François Rouzet, Bernard Songy, Alessandro Giordano, Alessia Gimelli, Fabien Hyafil, Roberto Sciagrà, Jan Bucerius, Hein J Verberne, Riemer H J A Slart, Oliver Lindner, Christopher Übleis, Marcus Hacker
No abstract text is available yet for this article.
October 7, 2016: European Journal of Nuclear Medicine and Molecular Imaging
M D'Arienzo, M L Cozzella, A Fazio, P De Felice, G Iaccarino, M D'Andrea, S Ungania, M Cazzato, K Schmidt, S Kimiaei, L Strigari
Peptide receptor therapy with (177)Lu-labelled somatostatin analogues is a promising tool in the management of patients with inoperable or metastasized neuroendocrine tumours. The aim of this work was to perform accurate activity quantification of (177)Lu in complex anthropomorphic geometry using advanced correction algorithms. Acquisitions were performed on the higher (177)Lu photopeak (208keV) using a Philips IRIX gamma camera provided with medium-energy collimators. System calibration was performed using a 16mL Jaszczak sphere surrounded by non-radioactive water...
September 28, 2016: Physica Medica: PM
Gijs H KleinJan, Daan Hellingman, Nynke S van den Berg, Matthias N van Oosterom, Kees Hendricksen, Simon Horenblas, Renato A Valdés Olmos, Fijs Wb van Leeuwen
INTRODUCTION: The clinically applied hybrid tracer indocyanine green (ICG)-(99m)Tc-nanocolloid enables combined radio- and fluorescence image guidance during sentinel node (SN) biopsy procedures. In order to provide optimal surgical guidance this tracer requires the presence of both gamma and fluorescence modalities in the operating room. We reasoned that combination and/or integration of these modalities could further evolve the hybrid surgical guidance concept. To study this potential we clinically applied two set-ups that included the combination of gamma detection modalities and an open surgery fluorescence camera...
September 29, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Lisa M Rowley, Kevin M Bradley, Philip Boardman, Aida Hallam, Daniel R McGowan
: Imaging on a gamma camera with Yttrium-90 ((90)Y) following selective internal radiotherapy (SIRT) may allow for verification of treatment delivery but suffers relatively poor spatial resolution and imprecise dosimetry calculation. (90)Y Positron Emission Tomography (PET) / Computed Tomography (CT) imaging is possible on 3D, time-of-flight machines however images are usually poor due to low count statistics and noise. A new PET reconstruction software using a Bayesian penalized likelihood (BPL) reconstruction algorithm (termed Q...
September 29, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Marine Claudin, Laetitia Imbert, Wassila Djaballah, Nicolas Veran, Sylvain Poussier, Véronique Roch, Mathieu Perrin, Antoine Verger, Henri Boutley, Gilles Karcher, Pierre-Yves Marie
PURPOSE: Gamma-cameras, with Cadmium-Zinc-Telluride (CZT) detectors, allow to perform myocardial perfusion imaging (MPI) with limited injected activities and recorded times. This study aimed at determining whether the routine assessment of left ventricular (LV) function with such limited counts protocols compares well with reference values from cardiac MRI. METHODS: The study included patients who have undergone cardiac MRI and an MPI routinely planned on a CZT camera with a low-dose protocol (120 MBq of Sestamibi for stress and 360 MBq at rest for 75 kg body weight), while targeting the recording of only 500 myocardial kcounts in order to limit the recording times (<10 minutes for stress, <4 minutes for rest)...
September 27, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Massimiliano Pacilio, Bartolomeo Cassano, Carlo Chiesa, Stefano Giancola, Mahila Ferrari, Cinzia Pettinato, Ernesto Amato, Federica Fioroni, Leda Lorenzon, Rosanna Pellegrini, Elisabetta Di Castro, Roberto Pani, Marta Cremonesi
PURPOSE: The aims of this work were to explore patient eligibility criteria for dosimetric studies in (223)Ra therapy and evaluate the effects of differences in gamma camera calibration procedures into activity quantification. METHODS: Calibrations with (223)Ra were performed with four gamma cameras (3/8-inch crystal) acquiring planar static images with double-peak (82 and 154keV, 20% wide) and MEGP collimator. The sensitivity was measured in air by varying activity, source-detector distance, and source diameter...
September 20, 2016: Physica Medica: PM
Mohamed A Ghoneim, M H Khedr, Wael M Elshemey
A point source is used to investigate the effect of water phantom thickness and source-to-detector distance (SDD) on the sensitivity and counting efficiency of a rectangular detector gamma camera. The increase in water thickness resulted in an increase in scatter fraction, a decrease in sensitivity, and counting efficiency. The increase in SDD resulted in a decrease in sensitivity and an increase in counting efficiency. An SDD of 0.79±0.02m is found to provide a good compromise for acceptable sensitivity and reasonable counting efficiency...
September 9, 2016: Applied Radiation and Isotopes
Randeep Kulshrestha, Sobhan Vinjamuri, Andrew England, Julie Nightingale, Peter Hogg
This article shall describe the role of (18)F-Sodium Fluoride ((18)F-NaF) PET/CT bone scanning in the staging of breast and prostate cancer. (18)F-NaF PET was initially utilised as a bone scanning agent in the 1960s and early 1970s, however its usage was restricted by the then available gamma cameras. The advent of hybrid PET/CT cameras in the late 1990s has shown a resurgence of interest in its usage and role. After a brief introduction, this paper will describe the radiopharmaceutical properties, dosimetry, pharmacokinetics, and mechanism of uptake of (18)F-NaF...
September 15, 2016: Journal of Nuclear Medicine Technology
Peter Kletting, Christiane Schuchardt, Harshad R Kulkarni, Mostafa Shahinfar, Aviral Singh, Gerhard Glatting, Richard P Baum, Ambros J Beer
In molecular radiotherapy with 177Lu-labeled prostate specific membrane antigen (PSMA) peptides, kidney and/or salivary glands doses limit the activity which can be administered. The aim of this work was to investigate the effect of the ligand amount and injected activity on the tumor-to-normal tissue biologically effective dose (BED) ratio for 177Lu-labeled PSMA peptides. For this retrospective study, a recently developed physiologically based pharmacokinetic model was adapted for PSMA targeting peptides. General physiological parameters were taken from the literature...
2016: PloS One
John E M Goldsmith, Mark D Gerling, James S Brennan
We describe a very compact (0.9 m high, 0.4 m diameter, 40 kg) battery operable neutron scatter camera designed for field deployment. Unlike most other systems, the configuration of the sixteen liquid-scintillator detection cells are arranged to provide omnidirectional (4π) imaging with sensitivity comparable to a conventional two-plane system. Although designed primarily to operate as a neutron scatter camera for localizing energetic neutron sources, it also functions as a Compton camera for localizing gamma sources...
August 2016: Review of Scientific Instruments
W Siman, J K Mikell, S C Kappadath
PURPOSE: To develop a practical background compensation (BC) technique to improve quantitative (90)Y-bremsstrahlung single-photon emission computed tomography (SPECT)/computed tomography (CT) using a commercially available imaging system. METHODS: All images were acquired using medium-energy collimation in six energy windows (EWs), ranging from 70 to 410 keV. The EWs were determined based on the signal-to-background ratio in planar images of an acrylic phantom of different thicknesses (2-16 cm) positioned below a (90)Y source and set at different distances (15-35 cm) from a gamma camera...
September 2016: Medical Physics
Ian S Negus, Robin B Holmes, Kirsty C Jordan, David A Nash, Gareth C Thorne, Margaret Saunders
PURPOSE: To make an adaptable, head shaped radionuclide phantom to simulate molecular imaging of the brain using clinical acquisition and reconstruction protocols. This will allow the characterization and correction of scanner characteristics, and improve the accuracy of clinical image analysis, including the application of databases of normal subjects. METHODS: A fused deposition modeling 3D printer was used to create a head shaped phantom made up of transaxial slabs, derived from a simulated MRI dataset...
September 2016: Medical Physics
Casper Beijst, Mattijs Elschot, Sandra van der Velden, Hugo W A M de Jong
BACKGROUND: Simultaneous real-time fluoroscopic and nuclear imaging could benefit image-guided (oncological) procedures. To this end, a hybrid modality is currently being developed by our group, by combining a c-arm with a gamma camera and a four-pinhole collimator. Accurate determination of the system parameters that describe the position of the x-ray tube, x-ray detector, gamma camera, and collimators is crucial to optimize image quality. The purpose of this study was to develop a calibration method that estimates the system parameters used for reconstruction...
December 2016: EJNMMI Physics
Diana Paez, Amalia Peix, Pilar Orellana, Joao Vitola, Fernando Mut, Claudia Gutiérrez, Crosby Plaza, Tarik Becic, Maurizio Dondi, Enrique Estrada
The burden of cardiovascular diseases (CVDs) in the world is ever growing. They represent the first cause of death worldwide and in Latin America. Nuclear cardiology has a well-established role in the management of patient with CVDs and is being increasingly integrated into the healthcare systems in the region. However, there remains variability as to the infrastructure available across the countries, in terms of existing technology, radiopharmaceuticals, and human resources. The approximate number of gamma (γ) cameras in the region is 1348, with an average of 2...
August 29, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
C Gillard, P Franken, J Darcourt, E Barranger
OBJECTIVE: Sentinel lymph node biopsy (SLNB) is a standard for patients with early breast cancer. Using a gamma-detecting probe connected to an infrared camera, the Declipse freehand SPECT (FhSPECT) system (Surgiceye(®)) is able to detect and locate any radioactive source in 3D. The objective of this study was to evaluate the potential interest of FhSPECT imaging for real-time guidance SLNB in breast cancer. METHODS: A prospective single-center clinical study assessed sensitivity and usability of FhSPECT for SLN detection and surgical guidance in breast cancer patients...
September 2016: Gynécologie, Obstétrique & Fertilité
Michael S Hofman, Rodney J Hicks
Nuclear medicine renal imaging provides important functional data to assist in the diagnosis and management of patients with a variety of renal disorders. Physiologically stable metal chelates like ethylenediaminetetraacetic acid (EDTA) and diethylenetriamine penta-acetate (DTPA) are excreted by glomerular filtration and have been radiolabelled with a variety of isotopes for imaging glomerular filtration and quantitative assessment of glomerular filtration rate. Gallium-68 ((68)Ga) EDTA PET usage predates Technetium-99m ((99m)Tc) renal imaging, but virtually disappeared with the widespread adoption of gamma camera technology that was not optimal for imaging positron decay...
September 2016: Seminars in Nuclear Medicine
Denis Agostini, Pierre-Yves Marie, Simona Ben-Haim, François Rouzet, Bernard Songy, Alessandro Giordano, Alessia Gimelli, Fabien Hyafil, Roberto Sciagrà, Jan Bucerius, Hein J Verberne, Riemer H J A Slart, Oliver Lindner
The trade-off between resolution and count sensitivity dominates the performance of standard gamma cameras and dictates the need for relatively high doses of radioactivity of the used radiopharmaceuticals in order to limit image acquisition duration. The introduction of cadmium-zinc-telluride (CZT)-based cameras may overcome some of the limitations against conventional gamma cameras. CZT cameras used for the evaluation of myocardial perfusion have been shown to have a higher count sensitivity compared to conventional single photon emission computed tomography (SPECT) techniques...
August 19, 2016: European Journal of Nuclear Medicine and Molecular Imaging
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