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https://www.readbyqxmd.com/read/28806773/quantitative-accuracy-of-177lu-spect-imaging-for-molecular-radiotherapy
#1
Emilio Mezzenga, Vincenzo D'Errico, Marco D'Arienzo, Lidia Strigari, Koutla Panagiota, Federica Matteucci, Stefano Severi, Giovanni Paganelli, Andrew Fenwick, David Bianchini, Francesco Marcocci, Anna Sarnelli
The purpose of this study is to investigate the optimal reference geometry for gamma camera calibration. Yet another question of interest was to assess the influence of the number of 3D Ordered Subsets Expectation Maximization (3D-OSEM) updates on activity quantification for SPECT imaging with 177Lu. The accuracy of 177Lu activity quantification was assessed both in small and in large objects. Two different reference geometries, namely a cylindrical homogeneous phantom and a Jaszczak 16 ml sphere surrounded by cold water, were used to determine the gamma camera calibration factor of a commercial SPECT/CT system...
2017: PloS One
https://www.readbyqxmd.com/read/28790781/to-study-the-efficacy-of-thallium-201-as-tumor-seeking-agent-and-to-study-its-role-in-therapeutic-response
#2
A V S Anil Kumar, P G Kumar, Sangeetha Sampath, V Suhag
BACKGROUND: Tumour seeking characteristics of TL-201 have been underutilized. The study was undertaken to evaluate the role of TL-201 scintigraphy in tumour imaging. METHODS: A total of 50 cases were studied over a period of 18 months (13 lymphomas, 11 breast carcinoma, 10 lung cancer, 6 of soft tissue sarcoma, 2 bone tumours and 4 cases each of thyroid and brain tumours). Thallium-201 chloride was injected IV in the dose range of 3-5 mCi. Imaging was done using Siemen's ECAM dual headed gamma camera...
July 2017: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/28729141/effects-of-transjugular-intrahepatic-portosystemic-shunt-tips-on-blood-volume-distribution-in-patients-with-cirrhosis
#3
Troels M Busk, Flemming Bendtsen, Jens H Henriksen, Stefan Fuglsang, Jens O Clemmesen, Fin S Larsen, Søren Møller
BACKGROUND: Cirrhosis is accompanied by portal hypertension with splanchnic and systemic arterial vasodilation, and central hypovolaemia. A transjugular intrahepatic portosystemic shunt (TIPS) alleviates portal hypertension, but also causes major haemodynamic changes. AIMS: To investigate effects of TIPS on regional blood volume distribution, and systemic haemodynamics. METHODS: Thirteen cirrhotic patients had their regional blood volume distribution determined with gamma-camera technique before and after TIPS...
June 27, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28704342/a-novel-compact-small-field-of-view-hybrid-gamma-camera-first-clinical-results
#4
Aik H Ng, Patricia E Blackshaw, Mohammed S Alqahtani, Layal K Jambi, Sarah L Bugby, John E Lees, Alan C Perkins
INTRODUCTION: Hybrid imaging has proven to be a major innovation in nuclear medicine, allowing the fusion of functional information with anatomical detail. In the past, the use of hybrid imaging such as PET-CT, PET-MRI and SPECT-CT has been of great clinical benefit; however, these scanners are relatively large and bulky. We have developed and investigated the clinical application of a compact small field of view hybrid gamma camera (HGC) that is suitable for small-organ imaging at the patient bedside...
July 12, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28685477/design-and-implementation-of-a-prototype-head-and-neck-phantom-for-the-performance-evaluation-of-gamma-imaging-systems
#5
Mohammed S Alqahtani, John E Lees, Sarah L Bugby, Piyal Samara-Ratna, Aik H Ng, Alan C Perkins
BACKGROUND: A prototype anthropomorphic head and neck phantom has been designed to simulate the adult head and neck anatomy including some internal organs and tissues of interest, such as thyroid gland and sentinel lymph nodes (SLNs). The design of the head and neck phantom includes an inner jig holding the simulated SLNs and thyroid gland. The thyroid gland structure was manufactured using three-dimensional (3D) printing taking into consideration the morphology and shape of a healthy adult thyroid gland...
December 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/28682842/dual-isotope-spect-study-with-epilepsy-patients-using-semiconductor-spect-system
#6
Tohru Shiga, Atsuro Suzuki, Kotarou Sakurai, Tsugiko Kurita, Wataru Takeuchi, Takuya Toyonaga, Kenji Hirata, Keiji Kobashi, Chietsugu Katoh, Naoki Kubo, Nagara Tamaki
PURPOSE: We developed a prototype CdTe SPECT system with 4-pixel matched collimator for brain study. This system provides high-energy-resolution (6.6%), high-sensitivity (220 cps/MBq/head), and high-spatial-resolution images. The aim of this study was to evaluate dual-isotope study of CBF and central benzodiazepine receptor (BZR) images using Tc-ECD and I-IMZ with the new SPECT system in patients with epilepsy comparing with single-isotope study using the conventional scintillation gamma camera...
September 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28651446/acute-and-chronic-in-vivo-effects-of-exposure-to-nicotine-and-propylene-glycol-from-an-e-cigarette-on-mucociliary-clearance-in-a-murine-model
#7
Beth L Laube, Nima Afshar-Mohajer, Kirsten Koehler, Gang Chen, Philip Lazarus, Joseph M Collaco, Sharon A McGrath-Morrow
OBJECTIVE: To determine the effect of an acute (1 week) and chronic (3 weeks) exposure to E-cigarette (E-cig) emissions on mucociliary clearance (MCC) in murine lungs. METHODS: C57BL/6 male mice (age 10.5 ± 2.4 weeks) were exposed for 20 min/day to E-cigarette aerosol generated by a Joyetech 510-T(®) E-cig containing either 0% nicotine (N)/propylene glycol (PG) for 1 week (n = 6), or 3 weeks (n = 9), or 2.4% N/PG for one week (n = 6), or 3 weeks (n = 9), followed by measurement of MCC...
April 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/28645684/detection-and-quantification-of-223-ra-uptake-in-bone-metastases-of-patients-with-castration-resistant-prostate-carcinoma-with-the-aim-of-determining-the-absorbed-dose-in-the-metastases
#8
P Mínguez, A Gómez de Iturriaga, I L Fernández, E Rodeño
PURPOSES: To obtain the necessary acquisition and calibration parameters in order to evaluate the possibility of detecting and quantifying (223)Ra uptake in bone metastases of patients treated for castration resistant prostate carcinoma. Furthermore, in the cases in which the activity can be quantified, to determine the absorbed dose. MATERIAL AND METHODS: Acquisitions from a Petri dish filled with (223)Ra were performed in the gamma camera. Monte Carlo simulations were also performed to study the partial volume effect...
June 20, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28644643/first-demonstration-of-a-scintillating-xenon-bubble-chamber-for-detecting-dark-matter-and-coherent-elastic-neutrino-nucleus-scattering
#9
D Baxter, C J Chen, M Crisler, T Cwiok, C E Dahl, A Grimsted, J Gupta, M Jin, R Puig, D Temples, J Zhang
A 30-g xenon bubble chamber, operated at Northwestern University in June and November 2016, has for the first time observed simultaneous bubble nucleation and scintillation by nuclear recoils in a superheated liquid. This chamber is instrumented with a CCD camera for near-IR bubble imaging, a solar-blind photomultiplier tube to detect 175-nm xenon scintillation light, and a piezoelectric acoustic transducer to detect the ultrasonic emission from a growing bubble. The time of nucleation determined from the acoustic signal is used to correlate specific scintillation pulses with bubble-nucleating events...
June 9, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28644425/significance-of-parathyroid-scintigraphy-and-correlation-of-findings-with-parathyroid-hormone-values-in-patients-undergoing-hemodialysis
#10
Nermana Ahmetbegović, Nadira Suljagić, Vahidin Katica
Aim To compare finding of thyroid gland scintigraphy with serum concentration of parathyroid hormone in patients undergoing hemodialysis. Methods This retrospective-prospective study included 50 patients undergoing hemodialysis with established hyperparathyroidism who were treated at Cantonal Hospital Zenica in the period 2009 - 2014. Besides anthropological data, concentration of parathyroid hormone in serum of patients was monitored too. Scintigraphy was performed at the Department of Nuclear Medicine using two-headed gamma camera Prism 2000xp...
August 1, 2017: Medicinski Glasnik
https://www.readbyqxmd.com/read/28611231/validation-of-the-left-ventricular-ejection-fraction-with-iq-spect-system-in-small-heart-patients
#11
Hiroto Yoneyama, Takayuki Shibutani, Takahiro Konishi, Asuka Mizutani, Hashimoto Ryosuke, Masahisa Onoguchi, Koichi Okuda, Shinro Matsuo, Kenichi Nakajima, Kinuya Seigo
The IQ-SPECT system equipped with a multifocal (SMARTZOOM) collimator using an ordered subset conjugate gradient minimization (OSCGM) algorithm reduces the acquisition time of myocardial perfusion imaging (MPI) compared to conventional gamma cameras equipped with low-energy high-resolution (LEHR) collimators. We compared IQ-SPECT with a conventional single-photon emission computed tomography (SPECT) system for estimating the left ventricular ejection fraction (LVEF) in small-heart patients. Methods: The study group consisted of 98 consecutive patients who underwent a 1-day stress-rest MPI study with a (99m)Tc-labeled agent for preoperative risk assessment...
June 13, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28610692/a-didactic-experiment-showing-the-compton-scattering-by-means-of-a-clinical-gamma-camera
#12
Ernesto Amato, Lucrezia Auditore, Alfredo Campennì, Fabio Minutoli, Mariapaola Cucinotta, Alessandro Sindoni, Sergio Baldari
We describe a didactic approach aimed to explain the effect of Compton scattering in nuclear medicine imaging, exploiting the comparison of a didactic experiment with a gamma camera with the outcomes from a Monte Carlo simulation of the same experimental apparatus. We employed a (99m)Tc source emitting 140.5keV photons, collimated in the upper direction through two pinholes, shielded by 6mm of lead. An aluminium cylinder was placed on the source at 50mm of distance. The energy of the scattered photons was measured on the spectra acquired by the gamma camera...
June 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28566259/multimodal-approach-in-radioguided-surgery-in-a-case-of-multiple-paraganglioma
#13
N Sánchez, A Tapias, H Bowles, E Delgado, R Almenara, D Fuster, S Vidal-Sicart
The case involves a 34-year-old who underwent surgical removal of a retroperitoneal paraganglioma adjacent to the left kidney lower pole, and visualized by CT and MRI. The (123)I-MIBG scan was positive for this lesion and, in addition, another more caudal uptake, of smaller size and intensity, was observed at L5 level. It was not considered for removal, due to its lack of morphological definition. One week after the surgery, the patient presented with difficult-to-control high blood pressure. A second (123)I-MIBG scan was performed...
May 26, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28559934/the-current-status-of-spect-or-spect-ct-in-south-korea
#14
REVIEW
Ikdong Yoo, Eun Kyoung Choi, Yong-An Chung
The first step to nuclear medicine in Korea started with introduction of the gamma camera in 1969. Although planar images with the gamma camera give important functional information, they have the limitations that result from 2-dimensional images. Single-photon emission computed tomography (SPECT) due to its 3-dimensional image acquisition is superior to earlier planar gamma imaging in image resolution and diagnostic accuracy. As demand for a hybrid functional and anatomical imaging device has increased, integrated SPECT/CT systems have been used...
June 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28535414/gamma-radiography-and-tomography-with-a-ccd-camera-and-co-60-source
#15
Robert Adams, Robert Zboray
Gamma imaging using a relatively low strength 5.8mCi laboratory Co-60 source and a CsI(Tl) scintillator screen read out by a CCD camera was investigated. A simple model was used to estimate the effective count rate, which was verified with experiments. Radiography and tomography of phantoms were used to determine the test setup spatial resolution of about 1.3-2.5mm. Exposure times were on the order of a couple minutes per radiograph. These tests demonstrate the value of the count rate model and the feasibility of the setup as a simple and low-cost solution for gamma imaging cases where acquisition time is flexible and resolution requirements are moderate...
May 17, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28522868/first-demonstration-of-multi-color-3-d-in-vivo-imaging-using-ultra-compact-compton-camera
#16
Aya Kishimoto, Jun Kataoka, Takanori Taya, Leo Tagawa, Saku Mochizuki, Shinji Ohsuka, Yuto Nagao, Keisuke Kurita, Mitsutaka Yamaguchi, Naoki Kawachi, Keiko Matsunaga, Hayato Ikeda, Eku Shimosegawa, Jun Hatazawa
In the field of nuclear medicine, single photon emission tomography and positron emission tomography are the two most common techniques in molecular imaging, but the available radioactive tracers have been limited either by energy range or difficulties in production and delivery. Thus, the use of a Compton camera, which features gamma-ray imaging of arbitrary energies from a few hundred keV to more than MeV, is eagerly awaited along with potential new tracers which have never been used in current modalities...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28515582/evaluation-of-mr-perfusion-abnormalities-in-organophosphorus-poisoning-and-its-correlation-with-spect
#17
K Uday Bhanu, Niranjan Khandelwal, Sameer Vyas, Paramjeet Singh, Anuj Prabhakar, B R Mittal, Ashish Bhalla
AIM: Acute organophosphate (OP) pesticide poisoning causes substantial morbidity and mortality worldwide. Many imaging modalities, such as computerized tomography (CT), magnetic resonance imaging (MRI), and single photon emission computed tomography (SPECT) of the brain, have been used for quantitative assessment of the acute brain insult caused by acute OP poisoning. Perfusion defects on SPECT in acutely poisoned patients with OPs have been described, however, MR perfusion abnormalities have not been described in the literature...
January 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/28461124/pharmacological-ppar%C3%AE-modulation-regulates-sebogenesis-and-inflammation-in-sz95-human-sebocytes
#18
A Mastrofrancesco, M Ottaviani, G Cardinali, E Flori, S Briganti, M Ludovici, C C Zouboulis, V Lora, E Camera, M Picardo
The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) controls the expression of genes involved in the regulation of lipid and glucose metabolism, cell proliferation/differentiation as well as inflammatory pathways. Pivotal studies in human sebocytes and isolated sebaceous glands have raised the interesting possibility that compounds acting on PPARγ can modulate sebaceous lipids and inflammation and, as such, may be useful in the treatment of acne. To investigate the role of this receptor in the regulation of lipid synthesis, proliferation and inflammation, we used the SZ95 sebaceous gland cell line stimulated with insulin...
August 15, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28458734/designing-a-new-molecular-probe-the-potential-role-for-tilmanocept-lymphoseek-%C3%A2-in-the-assessment-of-patients-with-painful-hip-and-knee-joint-prostheses
#19
O O Adesanya, C E Hutchinson
BACKGROUND: There is a long history of nuclear medicine developments in orthopaedics beginning in the early 20(th) century. Technetium-99m ((99m)Tc) has a short half-life of six hours, emits 140 keV gamma rays and is the most widely used isotope, imaged with the Anger (gamma) camera. Gamma image quality and test sensitivity in painful prosthetic joints can be improved with single photon emission computed tomography (SPECT) and SPECT/CT. Positron Emission Tomography-Computed Tomography (PET-CT) with Sodium Fluoride ((18)F-NaF) and (18)Fluorine-fluorodeoxyglucose ((18)F-FDG) PET have promising and limited roles respectively in the investigation of painful prosthetic joints...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/28458580/lymphoscintigraphy-detecting-alterations-of-upper-limb-lymphatic-flow-following-early-sentinel-lymph-node-biopsy-in-breast-cancer
#20
Almir Jose Sarri, Eduardo Tinois da Silva, Rene Aloisio da Costa Vieira, Katia Hiromoto Koga, Pedro Henrique Moriguchi Cação, Vitor Coca Sarri, Sonia Marta Moriguchi
PURPOSE: To evaluate early variations in lymphatic circulation of the arm pre- and post-sentinel lymph node biopsy (SLNB) and conservative breast surgery by lymphoscintigraphy (LS). PATIENTS AND METHODS: Between 2005 and 2012, 15 patients underwent LS before and after the SLNB (total=30 studies). The pre-SLNB study was considered the control. Early images within twenty minutes (dynamic and static images) and delayed images within ninety minutes of arms and armpits were acquired using a gamma camera...
2017: Breast Cancer: Targets and Therapy
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