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https://www.readbyqxmd.com/read/27910821/reply-to-comment-on-imaging-of-prompt-gamma-rays-emitted-during-delivery-of-clinical-proton-beams-with-a-compton-camera-feasibility-studies-for-range-verification
#1
Jerimy C Polf, Stephen Avery, Dennis S Mackin, Sam Beddar
A reply is provided to the points raised in the comment by Dr Sitek (2016 Phys. Med. Biol. 61 8941) on Polf et al (2015 Phys. Med. Biol. 60 7085).
December 21, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27910819/comment-on-imaging-of-prompt-gamma-rays-emitted-during-delivery-of-clinical-proton-beams-with-a-compton-camera-feasibility-studies-for-range-verification
#2
Arkadiusz Sitek
The origin ensemble (OE) algorithm is a new method used for image reconstruction from nuclear tomographic data. The main advantage of this algorithm is the ease of implementation for complex tomographic models and the sound statistical theory. In this comment, the author provides the basics of the statistical interpretation of OE and gives suggestions for the improvement of the algorithm in the application to prompt gamma imaging as described in Polf et al (2015 Phys. Med. Biol. 60 7085).
December 21, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27910639/performance-of-the-prototype-labr3-spectrometer-developed-for-the-jet-gamma-ray-camera-upgrade
#3
D Rigamonti, A Muraro, M Nocente, V Perseo, G Boltruczyk, A Fernandes, J Figueiredo, L Giacomelli, G Gorini, M Gosk, V Kiptily, S Korolczuk, S Mianowski, A Murari, R C Pereira, E P Cippo, I Zychor, M Tardocchi
In this work, we describe the solution developed by the gamma ray camera upgrade enhancement project to improve the spectroscopic properties of the existing JET γ-ray camera. Aim of the project is to enable gamma-ray spectroscopy in JET deuterium-tritium plasmas. A dedicated pilot spectrometer based on a LaBr3 crystal coupled to a silicon photo-multiplier has been developed. A proper pole zero cancellation network able to shorten the output signal to a length of 120 ns has been implemented allowing for spectroscopy at MHz count rates...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910625/gamma-ray-spectroscopy-at-mhz-counting-rates-with-a-compact-labr3-detector-and-silicon-photomultipliers-for-fusion-plasma-applications
#4
M Nocente, D Rigamonti, V Perseo, M Tardocchi, G Boltruczyk, A Broslawski, A Cremona, G Croci, M Gosk, V Kiptily, S Korolczuk, M Mazzocco, A Muraro, E Strano, I Zychor, G Gorini
Gamma-ray spectroscopy measurements at MHz counting rates have been carried out, for the first time, with a compact spectrometer based on a LaBr3 scintillator and silicon photomultipliers. The instrument, which is also insensitive to magnetic fields, has been developed in view of the upgrade of the gamma-ray camera diagnostic for α particle measurements in deuterium-tritium plasmas of the Joint European Torus. Spectra were measured up to 2.9 MHz with a projected energy resolution of 3%-4% in the 3-5 MeV range, of interest for fast ion physics studies in fusion plasmas...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910571/a-collimated-neutron-detector-for-rfp-plasmas-in-mst
#5
W J Capecchi, J K Anderson, P J Bonofiglo, J Kim, S Sears
The neutron emissivity profile in the Madison Symmetric Torus is being reconstructed through the use of a collimated neutron detector. A scintillator-photomultiplier tube (PMT) system is employed to detect the fusion neutrons with the plasma viewing volume defined by a 55 cm deep, 5 cm diameter aperture. Effective detection of neutrons from the viewing volume is achieved through neutron moderation using 1300 lbs of high density polyethylene shielding, which modeling predicts attenuates the penetrating flux by a factor of 10(4) or more...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910457/applying-the-new-gamma-ray-imager-diagnostic-to-measurements-of-runaway-electron-bremsstrahlung-radiation-in-the-diii-d-tokamak-invited
#6
C M Cooper, D C Pace, C Paz-Soldan, N Commaux, N W Eidietis, E M Hollmann, D Shiraki
A new gamma ray imager (GRI) is developed to probe the electron distribution function with 2D spatial resolution during runaway electron (RE) experiments at the DIII-D tokamak. The diagnostic is sensitive to 0.5-100 MeV gamma rays, allowing characterization of the RE distribution function evolution during RE growth and dissipation. The GRI consists of a lead "pinhole camera" mounted on the DIII-D midplane with 123 honeycombed tangential chords 20 cm wide that span the vessel interior. Up to 30 bismuth germanate (BGO) scintillation detectors capture RE bremsstrahlung radiation for Pulse Height Analysis (PHA) capable of discriminating up to 20 000 pulses per second...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27908169/flexible-mini-gamma-camera-reconstructions-of-extended-sources-using-step-and-shoot-and-list-mode
#7
José Gardiazabal, Philipp Matthies, Jakob Vogel, Benjamin Frisch, Nassir Navab, Sibylle Ziegler, Tobias Lasser
PURPOSE: Hand- and robot-guided mini gamma cameras have been introduced for the acquisition of single-photon emission computed tomography (SPECT) images. Less cumbersome than whole-body scanners, they allow for a fast acquisition of the radioactivity distribution, for example, to differentiate cancerous from hormonally hyperactive lesions inside the thyroid. This work compares acquisition protocols and reconstruction algorithms in an attempt to identify the most suitable approach for fast acquisition and efficient image reconstruction, suitable for localization of extended sources, such as lesions inside the thyroid...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27904875/history-and-perspectives-of-nuclear-medicine-in-bangladesh
#8
Raihan Hussain
Bangladesh is one of the smaller states in Asia. But it has a long and rich history of nuclear medicine for over sixty years. The progress in science and technology is always challenging in a developing country. In 1958, work for the first Nuclear Medicine facility was commenced in Dhaka in a tin-shed known as 'Radioisotope Centre' and was officially inaugurated in 1962. Since the late 50s of the last century nuclear medicine in Bangladesh has significantly progressed through the years in its course of development, but still the facilities are inadequate...
2016: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/27904874/imaging-of-accidental-contamination-by-fluorine-18-solution-a-quick-troubleshooting-procedure
#9
Kalevi Kairemo, Aki Kangasmäki
To the best of our knowledge, imaging of accidental exposure to radioactive fluorine-18 (F-18) due to liquid spill has not been described earlier in the scientific literature. The short half-life of F-18 (t½=110 min), current radiation safety requirements, and Good Manufacturing Practice (GMP) regulations on radiopharmaceuticals have restrained the occurrence of these incidents. The possibility of investigating this type of incidents by gamma and positron imaging is also quite limited. Additionally, a quick and precise analysis of radiochemical contamination is cumbersome and sometimes challenging if the spills of radioactive materials are low in activity...
2016: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/27904871/in-vivo-measurement-and-characterization-of-a-novel-formulation-of-177-lu-dota-octreotate
#10
Dale L Bailey, Thomas M Hennessy, Kathy P Willowson, E Courtney Henry, David Lh Chan, Alireza Aslani, Paul J Roach
OBJECTIVES: Lutetium-177 can be made with high specific activity and with no other isotopes of lutetium present, referred to as "No Carrier Added" (NCA) (177)Lu. We have radiolabelled DOTA-conjugated peptide DOTA-(Tyr(3))-octreotate with NCA (177)Lu ("NCA-LuTATE") and used it in nearly 40 therapeutic administrations for subjects with neuroendocrine tumours or meningiomas. In this paper, we report on our initial studies on aspects of the biodistribution and dosimetry of NCA-LuTATE from gamma camera 2D whole body (WB) and quantitative 3D SPECT (qSPECT) (177)Lu imaging...
2016: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/27857516/sentinel-lymph-node-scintigraphy-in-cutaneous-melanoma-using-a-planar-calibration-phantom-filled-with-tc-99m-pertechnetate-solution-for-body-contouring
#11
Claudiu Peştean, Elena Bărbuş, Andra Piciu, Maria Iulia Larg, Alexandrina Sabo, Cristina Moisescu-Goia, Doina Piciu
BACKGROUND AND AIMS: Melanoma is a disease that has an increasing incidence worldwide. Sentinel lymph node scintigraphy is a diagnostic tool that offers important information regarding the localization of the sentinel lymph nodes offering important input data to establish a pertinent and personalized therapeutic strategy. The golden standard in body contouring for sentinel lymph node scintigraphy is to use a planar flood source of Cobalt-57 (Co-57) placed behind the patients, against the gamma camera...
2016: Clujul Medical (1957)
https://www.readbyqxmd.com/read/27821346/radiolabeling-and-biological-characterization-of-tpgs-based-nanomicelles-by-means-of-small-animal-imaging
#12
Fiorella Carla Tesan, Mariano Gastón Portillo, Marcela Analía Moretton, Ezequiel Bernabeu, Diego Andrés Chiappetta, Maria Jimena Salgueiro, Marcela Beatriz Zubillaga
INTRODUCTION: In recent years, nanomedicines have raised as a powerful tool to improve prevention, diagnosis and treatment of different pathologies. Among the most well investigated biomaterials, D-α-tocopheryl polyethylene glycol succinate (also known as TPGS) has been on the spot for the last decade. We therefore designed a method to biologically characterize TPGS-based nanomicelles by labeling them with (99m)Tc. METHODS: Labeling process was performed by a direct method...
September 30, 2016: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/27806581/analytically-based-photon-scatter-modeling-for-a-multipinhole-cardiac-spect-camera
#13
Amir Pourmoghaddas, R Glenn Wells
PURPOSE: Dedicated cardiac SPECT scanners have improved performance over standard gamma cameras allowing reductions in acquisition times and/or injected activity. One approach to improving performance has been to use pinhole collimators, but this can cause position-dependent variations in attenuation, sensitivity, and spatial resolution. CT attenuation correction (AC) and an accurate system model can compensate for many of these effects; however, scatter correction (SC) remains an outstanding issue...
November 2016: Medical Physics
https://www.readbyqxmd.com/read/27793632/radioguided-surgery-and-the-gostt-concept-from-pre-operative-image-and-intraoperative-navigation-to-image-assisted-excision
#14
H Bowles, N Sánchez, A Tapias, P Paredes, F Campos, C Bluemel, R A Valdés Olmos, S Vidal-Sicart
Radio-guided surgery has been developed for application in those disease scheduled for surgical management, particularly in areas of complex anatomy. This is based on the use of pre-operative scintigraphic planar, tomographic and fused SPECT/CT images, and the possibility of 3D reconstruction for the subsequent intraoperative locating of active lesions using handheld devices (detection probes, gamma cameras, etc.). New tracers and technologies have also been incorporated into these surgical procedures. The combination of visual and acoustic signals during the intraoperative procedure has become possible with new portable imaging modalities...
October 25, 2016: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/27783160/diagnosis-of-raynaud-s-phenomenon-by-99m-tc-pertechnetate-hand-perfusion-scintigraphy-a-pilot-study
#15
Slavica Pavlov-Dolijanovic, Nebojsa Petrovic, Nada Vujasinovic Stupar, Nemanja Damjanov, Goran Radunovic, Dragan Babic, Dragana Sobic-Saranovic, Vera Artiko
We assess the usefulness of (99m)Tc-pertechnetate hand perfusion scintigraphy in patients with Raynaud's phenomenon (RP). The study population consisted of 18 patients with primary RP, 25 patients with secondary RP within systemic sclerosis (SSc), and ten healthy individuals. Gamma camera dynamic first-pass study during the first 60 s and a static scintigraphy after 5 min were recorded following a bolus injection of (99m)Tc-pertechnetate via a cubital vein. Regions of interest were drawn on the summed images around the fingers and the palmar region...
October 25, 2016: Rheumatology International
https://www.readbyqxmd.com/read/27782695/reconstruction-of-multiple-pinhole-micro-spect-data-using-origin-ensembles
#16
Morgan C Lyon, Arkadiusz Sitek, Scott D Metzler, Stephen C Moore
PURPOSE: The authors are currently developing a dual-resolution multiple-pinhole microSPECT imaging system based on three large NaI(Tl) gamma cameras. Two multiple-pinhole tungsten collimator tubes will be used sequentially for whole-body "scout" imaging of a mouse, followed by high-resolution (hi-res) imaging of an organ of interest, such as the heart or brain. Ideally, the whole-body image will be reconstructed in real time such that data need only be acquired until the area of interest can be visualized well-enough to determine positioning for the hi-res scan...
October 2016: Medical Physics
https://www.readbyqxmd.com/read/27779120/towards-clinical-application-prompt-gamma-imaging-of-passively-scattered-proton-fields-with-a-knife-edge-slit-camera
#17
M Priegnitz, S Barczyk, L Nenoff, C Golnik, I Keitz, T Werner, S Mein, J Smeets, F Vander Stappen, G Janssens, L Hotoiu, F Fiedler, D Prieels, W Enghardt, G Pausch, C Richter
Prompt γ-ray imaging with a knife-edge shaped slit camera provides the possibility of verifying proton beam range in tumor therapy. Dedicated experiments regarding the characterization of the camera system have been performed previously. Now, we aim at implementing the prototype into clinical application of monitoring patient treatments. Focused on this goal of translation into clinical operation, we systematically addressed remaining challenges and questions. We developed a robust energy calibration routine and corresponding quality assurance protocols...
November 21, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27774745/repeatability-and-reliability-of-glomerular-filtration-rate-determination-via-gamma-camera-uptake-of-tc-99m-dtpa-in-cats-with-chronic-kidney-disease
#18
Amy E Felumlee, Angela J Marolf, Elissa K Randall, Annette M Bachand, Jessica M Quimby
Measurement of glomerular filtration rate (GFR) via gamma camera uptake of 99mTc-diethylenetriaminepentaacetic acid is a standard method for quantifying renal function. Aims of this retrospective, observer agreement study were to determine intra- and interobserver variation in GFR values for cats with chronic kidney disease and to determine whether renal insufficiency classification changed between observers. Guideline cut-points were established for the difference in repeated GFRs to differentiate changes caused by therapeutic effect vs...
October 23, 2016: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/27759832/preclinical-molecular-imaging-development-of-instrumentation-for-translational-research-with-small-laboratory-animals
#19
Jorge Mejia, Ana Claudia Camargo Miranda, Ana Claudia Ranucci Durante, Larissa Rolim de Oliveira, Marycel Rosa Felisa Figols de Barboza, Katerin Taboada Rosell, Daniele Pereira Jardim, Alexandre Holthausen Campos, Marilia Alves Dos Reis, Marcela Forli Catanoso, Orfa Yineth Galvis-Alonso, Francisco Romero Cabral
Objective: To present the result of upgrading a clinical gamma-camera to be used to obtain in vivo tomographic images of small animal organs, and its application to register cardiac, renal and neurological images. Methods: An updated version of the miniSPECT upgrading device was built, which is composed of mechanical, electronic and software subsystems. The device was attached to a Discovery VH (General Electric Healthcare) gamma-camera, which was retired from the clinical service and installed at the Centro de Imagem Pré-Clínica of the Hospital Israelita Albert Einstein...
July 2016: Einstein
https://www.readbyqxmd.com/read/27739174/a-novel-tc-99%C3%A2-m-and-fluorescence-labeled-peptide-as-a-multimodal-imaging-agent-for-targeting-angiogenesis-in-a-murine-tumor-model
#20
Myoung Hyoun Kim, Chang Guhn Kim, Seul-Gi Kim, Dae-Weung Kim
The serine-aspartic acid-valine (SDV) peptide binds specifically to integrin αV β3 . In the present study, we successfully developed a TAMRA-GHEG-ECG-SDV peptide labeled with both Tc-99 m and TAMRA to target the integrin αV β3 of tumor cells; furthermore, we evaluated the diagnostic performance of Tc-99 m TAMRA-GHEG-ECG-SDV as a dual-modality imaging agent for tumor of the murine model. TAMRA-GHEG-ECG-SDV was synthesized using Fmoc solid-phase peptide synthesis. Radiolabeling of TAMRA-GHEG-ECG-SDV with Tc-99 m was done using ligand exchange methods...
October 14, 2016: Contrast Media & Molecular Imaging
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