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https://www.readbyqxmd.com/read/28192280/iterative-reconstruction-of-sipm-light-response-functions-in-a-square-shaped-compact-gamma-camera
#1
Andrey Morozov, Francisco Alves, Joao Marcos, Raimundo Martins, Luis Pereira, Vladimir Solovov, Vitaly Chepel
Compact gamma cameras with a square-shaped monolithic scintillator crystal and an array of silicon photomultipliers (SiPMs) are actively being developed for applications in areas such as small animal imaging, cancer diagnostics and radiotracer guided surgery. Statistical methods of position reconstruction, which are potentially superior to the traditional centroid method, require accurate knowledge of the spatial response of each photomultiplier. Using both Monte Carlo simulations and experimental data obtained with a camera prototype, we show that the spatial response of all photomultipliers (light response functions) can be parameterized with axially symmetric functions obtained iteratively from flood field irradiation data...
February 13, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28155883/first-on-site-true-gamma-ray-imaging-spectroscopy-of-contamination-near-fukushima-plant
#2
Dai Tomono, Tetsuya Mizumoto, Atsushi Takada, Shotaro Komura, Yoshihiro Matsuoka, Yoshitaka Mizumura, Makoto Oda, Toru Tanimori
We have developed an Electron Tracking Compton Camera (ETCC), which provides a well-defined Point Spread Function (PSF) by reconstructing a direction of each gamma as a point and realizes simultaneous measurement of brightness and spectrum of MeV gamma-rays for the first time. Here, we present the results of our on-site pilot gamma-imaging-spectroscopy with ETCC at three contaminated locations in the vicinity of the Fukushima Daiichi Nuclear Power Plants in Japan in 2014. The obtained distribution of brightness (or emissivity) with remote-sensing observations is unambiguously converted into the dose distribution...
February 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28155870/establishment-of-imaging-spectroscopy-of-nuclear-gamma-rays-based-on-geometrical-optics
#3
Toru Tanimori, Yoshitaka Mizumura, Atsushi Takada, Shohei Miyamoto, Taito Takemura, Tetsuro Kishimoto, Shotaro Komura, Hidetoshi Kubo, Shunsuke Kurosawa, Yoshihiro Matsuoka, Kentaro Miuchi, Tetsuya Mizumoto, Yuma Nakamasu, Kiseki Nakamura, Joseph D Parker, Tatsuya Sawano, Shinya Sonoda, Dai Tomono, Kei Yoshikawa
Since the discovery of nuclear gamma-rays, its imaging has been limited to pseudo imaging, such as Compton Camera (CC) and coded mask. Pseudo imaging does not keep physical information (intensity, or brightness in Optics) along a ray, and thus is capable of no more than qualitative imaging of bright objects. To attain quantitative imaging, cameras that realize geometrical optics is essential, which would be, for nuclear MeV gammas, only possible via complete reconstruction of the Compton process. Recently we have revealed that "Electron Tracking Compton Camera" (ETCC) provides a well-defined Point Spread Function (PSF)...
February 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28153955/bi-modal-molecular-imaging-of-porcine-urinary-bladder-sentinel-lymph-nodes
#4
Hak J Lee, Christopher V Barback, Carl K Hoh, Qin Zhengtao, Kader Kareem, Hall J David, David R Vera, Christopher J Kane
: The primary objective was to test the ability of a laparoscopic camera system to detect the fluorescent signal emanating from sentinel lymph nodes approximately two days after injection and imaging of a positron-emitting molecular imaging agent into the submucosa of the porcine urinary bladder. METHODS: Three female pigs underwent a submucosal injection of the bladder with fluorescent-tagged tilmanocept, radiolabeled with both gallium-68 (68Ga) and technetium-99m (99mTc)...
February 2, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28146205/comparison-between-radionuclide-ventriculography-and-echocardiography-for-quantification-of-left-ventricular-systolic-function-in-rats-exposed-to-doxorubicin
#5
Luciano Fonseca Lemos de Oliveira, João Lucas O'Connell, Eduardo Elias Vieira de Carvalho, Érica Carolina Campos Pulici, Minna Moreira Dias Romano, Benedito Carlos Maciel, Marcus Vinicius Simões
BACKGROUND: Radionuclide ventriculography (RV) is a validated method to evaluate the left ventricular systolic function (LVSF) in small rodents. However, no prior study has compared the results of RV with those obtained by other imaging methods in this context. OBJECTIVES: To compare the results of LVSF obtained by RV and echocardiography (ECHO) in an experimental model of cardiotoxicity due to doxorubicin (DXR) in rats. METHODS: Adult male Wistar rats serving as controls (n = 7) or receiving DXR (n = 22) in accumulated doses of 8, 12, and 16 mg/kg were evaluated with ECHO performed with a Sonos 5500 Philips equipment (12-MHz transducer) and RV obtained with an Orbiter-Siemens gamma camera using a pinhole collimator with a 4-mm aperture...
January 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28133745/technical-note-development-of-a-combined-molecular-breast-imaging-ultrasound-system-for-diagnostic-evaluation-of-mbi-detected-lesions
#6
Michael K O'Connor, Melissa M Morrow, Thuy Tran, Carrie B Hruska, Amy L Conners, Katie N Hunt
PURPOSE: The purpose of this study was to perform a pilot evaluation of an integrated molecular breast imaging/ultrasound (MBI/US) system designed to enable, in real-time, the registration of US to MBI and diagnostic evaluation of breast lesions detected on MBI. METHODS: The MBI/US system was constructed by modifying an existing dual-head cadmium zinc telluride (CZT)-based MBI gamma camera. The upper MBI detector head was replaced with a mesh panel, which allowed an ultrasound probe to access the breast...
December 9, 2016: Medical Physics
https://www.readbyqxmd.com/read/28130765/-123-i-fp-cit-enc-dat-normal-database-the-impact-of-the-reconstruction-and-quantification-methods
#7
Livia Tossici-Bolt, John C Dickson, Terez Sera, Jan Booij, Susanne Asenbaun-Nan, Maria C Bagnara, Thierry Vander Borght, Cathrine Jonsson, Robin de Nijs, Swen Hesse, Pierre M Koulibaly, Umit O Akdemir, Michel Koole, Klaus Tatsch, Andrea Varrone
BACKGROUND: [(123)I]FP-CIT is a well-established radiotracer for the diagnosis of dopaminergic degenerative disorders. The European Normal Control Database of DaTSCAN (ENC-DAT) of healthy controls has provided age and gender-specific reference values for the [(123)I]FP-CIT specific binding ratio (SBR) under optimised protocols for image acquisition and processing. Simpler reconstruction methods, however, are in use in many hospitals, often without implementation of attenuation and scatter corrections...
December 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/28120154/a-european-myocardial-123-i-mibg-cross-calibration-phantom-study
#8
Derk O Verschure, Edwin Poel, Kenichi Nakajima, Koichi Okuda, Berthe L F van Eck-Smit, G Aernout Somsen, Hein J Verberne
AIM: Planar myocardial (123)I-meta-iodobenzylguanidine ((123)I-mIBG) scintigraphy is a highly reproducible technique. However, differences in collimator use are one of the most important factors that cause variation among institutions and studies in heart-to-mediastinum (H/M) ratio. Therefore, standardization among various gamma camera-collimator combinations is needed. Previously, a phantom has been developed to cross-calibrate different acquisition conditions in Japan. For further cross-calibration of European myocardial (123)I-mIBG imaging, the aim of this study was to collect (123)I-mIBG data for H/M ratios from common European gamma camera vendors...
January 24, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28118951/brachyview-combining-ldr-seed-positions-with-transrectal-ultrasound-imaging-in-a-prostate-gel-phantom
#9
S Alnaghy, D L Cutajar, J A Bucci, K Enari, M Safavi-Naeini, M Favoino, M Tartaglia, F Carriero, J Jakubek, S Pospisil, M Lerch, A B Rosenfeld, M Petasecca
PURPOSE: BrachyView is a novel in-body imaging system which aims to provide LDR brachytherapy seeds position reconstruction within the prostate in real-time. The first prototype is presented in this study: the probe consists of a gamma camera featuring three single cone pinhole collimators embedded in a tungsten tube, above three, high resolution pixelated detectors (Timepix). METHODS: The prostate was imaged with a TRUS system using a sagittal crystal with a 2...
January 21, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28108979/analysis-of-stress-only-imaging-comparing-upright-and-supine-czt-camera-acquisition-to-conventional-gamma-camera-images-with-and-without-attenuation-correction-with-coronary-angiography-as-a-reference
#10
Zenith A Jameria, Mouhamad Abdallah, Mariano Fernandez-Ulloa, Robert O'Donnell, Alok K Dwivedi, Erica Washburn, Naseer Khan, Mahyar Khaleghi, Nischelle Kalakota, Myron C Gerson
BACKGROUND: Diagnostic performance of stress-only imaging using a Cadmium-Zinc-Telluride (CZT) camera has not been directly compared in the same patients to stress-only attenuation-corrected conventional Anger camera images. METHODS: 112 subjects with correlative coronary angiographic data and 40 subjects with <5% pre-test likelihood of coronary disease completed attenuation-corrected stress-only images on a conventional Anger camera and uncorrected upright and supine stress images on a CZT camera...
January 20, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28106567/fractional-anisotropy-and-mean-diffusion-as-measures-of-dopaminergic-function-in-parkinson-s-disease-challenging-results
#11
Niklas Lenfeldt, Johan Eriksson, Björn Åström, Lars Forsgren, Susanna Jakobson
BACKGROUND: Diffusion tensor imaging (DTI) has been purported as an imaging technique to assess dopaminergic degeneration in Parkinson's disease. OBJECTIVE: To test if fractional anisotropy (FA) and mean diffusion (MD) in the basal ganglia as measured by DTI correlates with dopaminergic function as measured by dopamine transporter (DAT) and dopamine D2-receptor (D2R) SPECT. METHODS: One-hundred and eleven patients with Parkinson's disease (71±10 years) and thirty-one controls (68±7 years) performed DTI, DAT and D2R SPECT at baseline and four follow-ups (1-year: 89 patients/zero controls; 3-year: 72/11; 5-year: 48/17; and 8-year: 13/13)...
January 17, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28102947/a-feasibility-study-of-an-integrated-nir-gamma-visible-imaging-system-for-endoscopic-sentinel-lymph-node-mapping
#12
Han Gyu Kang, Ho-Young Lee, Kyeong Min Kim, Seong-Hyun Song, Gun Chul Hong, Seong Jong Hong
PURPOSE: The aim of this study is to integrate NIR, gamma, and visible imaging tools into a single endoscopic system to overcome the limitation of NIR using gamma imaging and to demonstrate the feasibility of endoscopic NIR/gamma/visible fusion imaging for sentinel lymph node (SLN) mapping with a small animal. METHODS: The endoscopic NIR/gamma/visible imaging system consists of a tungsten pinhole collimator, a plastic focusing lens, a BGO crystal (11 × 11 × 2 mm(3) ), a fiber-optic taper (front = 11 × 11 mm(2) , end = 4 × 4 mm(2) ), a 122-cm long endoscopic fiber bundle, an NIR emission filter, a relay lens, and a CCD camera...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28091980/comparison-of-tc-99m-maraciclatide-and-tc-99m-sestamibi-molecular-breast-imaging-in-patients-with-suspected-breast-cancer
#13
Michael K O'Connor, Melissa M B Morrow, Katie N Hunt, Judy C Boughey, Dietlind L Wahner-Roedler, Amy Lynn Conners, Deborah J Rhodes, Carrie B Hruska
BACKGROUND: Molecular breast imaging (MBI) performed with (99m)Tc sestamibi has been shown to be a valuable technique for the detection of breast cancer. Alternative radiotracers such as (99m)Tc maraciclatide may offer improved uptake in breast lesions. The purpose of this study was to compare relative performance of (99m)Tc sestamibi and (99m)Tc maraciclatide in patients with suspected breast cancer, using a high-resolution dedicated gamma camera for MBI. Women with breast lesions suspicious for malignancy were recruited to undergo two MBI examinations-one with (99m)Tc sestamibi and one with (99m)Tc maraciclatide...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28072581/-131-i-activity-quantification-of-gamma-camera-planar-images
#14
Raquel Barquero, Hugo P Garcia, Monica G Incio, Pablo Minguez, Alexander Cardenas, Daniel Martínez, Michael Lassmann
A procedure to estimate the activity in target tissues in patients during the therapeutic administration of (131)I radiopharmaceutical treatment for thyroid conditions (hyperthyroidism and differentiated thyroid cancer) using a gamma camera (GC) with a high energy (HE) collimator, is proposed. Planar images are acquired for lesions of different sizes r, and at different distances d, in two HE GC systems. Defining a region of interest (ROI) on the image of size r, total counts n g are measured. Sensitivity S (cps MBq(-1)) in each acquisition is estimated as the product of the geometric G and the intrinsic efficiency η 0...
February 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28048841/mo-fg-campus-jep1-02-proton-range-verification-of-scanned-pencil-beams-using-prompt-gamma-imaging
#15
Y Xie, E Bentefour, G Janssens, J Smeets, D Dolney, L Yin, L Hotoiu, F Vander Stappen, S Avery, F O'Grady, D Prieels, J McDonough, T Solberg, A Lin, B Teo
PURPOSE: Prompt gammas are emitted along the proton beam path and have an emission profile correlated with the depth dose profile. In this study, the accuracy of in-vivo proton range verification using a 1-D prompt gamma camera is assessed. METHODS: The 1-D camera is comprised of a tungsten slit collimator positioned in front of a linear array of LYSO scintillating crystals coupled to silicon photomultipliers. The imaged gamma profiles of individual pencil beam spots and energy layers were analyzed by determining the relative shifts from the expected gamma profiles based on analytic prediction or reference measurements...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048840/su-f-j-208-prompt-gamma-imaging-based-prediction-of-bragg-peak-position-for-realistic-treatment-error-scenarios
#16
Y Xing, B Macq, G Janssens, L Bondar
PURPOSE: To quantify the accuracy in predicting the Bragg peak position using simulated in-room measurements of prompt gamma (PG) emissions for realistic treatment error scenarios that combine several sources of errors. METHODS: Prompt gamma measurements by a knife-edge slit camera were simulated using an experimentally validated analytical simulation tool. Simulations were performed, for 143 treatment error scenarios, on an anthropomorphic phantom and a pencil beam scanning plan for nasal cavity...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048785/su-f-j-08-quantitative-spect-imaging-of-ra-223-in-a-phantom
#17
J Yue, R Hobbs, G Sgouros, E Frey
PURPOSE: Ra-223 therapy of prostate cancer bone metastases is being used to treat patients routinely. However, the absorbed dose distribution at the macroscopic and microscopic scales remains elusive, due to the inability to image the small activities injected. Accurate activity quantification through imaging is essential to calculate the absorbed dose in organs and sub-units in radiopharmaceutical therapy, enabling personalized absorbed dose-based treatment planning methodologies and more effective and optimal treatments...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048450/su-g-iep4-02-application-of-changs-attenuation-correction-technique-for-spect-partial-angle-acquisition-of-jaszczak-phantom
#18
K Saha, J Barbarits, R Humenik, J Johnson, B Murray, S Hoyt
PURPOSE: Chang's mathematical formulation is a common method of attenuation correction applied on reconstructed Jaszczak phantom images. Though Chang's attenuation correction method has been used for 360° angle acquisition, its applicability for 180° angle acquisition remains a question with one vendor's camera software producing artifacts. The objective of this work is to ensure that Chang's attenuation correction technique can be applied for reconstructed Jaszczak phantom images acquired in both 360° and 180° mode...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048363/su-f-t-518-development-and-characterization-of-a-gated-treatment-system-implemented-with-an-in-house-optical-tracking-system-and-the-elekta-response-interface
#19
B Barraclough, J Park, F Li, B Lu, J Li, C Liu, G Yan
PURPOSE: To report the development and characterization of the first in-house gating system implemented with an optical tracking system (OTS) and the Elekta Response™ interface. METHODS: The Response™ connects a patient tracking system with a linac, enabling the tracking system to control radiation delivery. The developed system uses an in-house OTS to monitor patient breathing. The OTS consists of two infrared-based cameras, tracking markers affixed on patient...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048215/mo-ab-206-00-nuclear-medicine-physics-and-testing
#20
Sharon White
: This education session will cover the physics and operation principles of gamma cameras and PET scanners. The first talk will focus on PET imaging. An overview of the principles of PET imaging will be provided, including positron decay physics, and the transition from 2D to 3D imaging. More recent advances in hardware and software will be discussed, such as time-of-flight imaging, and improvements in reconstruction algorithms that provide for options such as depth-of-interaction corrections...
June 2016: Medical Physics
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