keyword
MENU ▼
Read by QxMD icon Read
search

1331

keyword
https://www.readbyqxmd.com/read/28468510/safety-and-efficacy-of-bridging-with-low-molecular-weight-heparin-during-temporary-interruptions-of-warfarin-a-register-based-cohort-study
#1
Vilhelm Sjögren, Bartosz Grzymala-Lubanski, Henrik Renlund, Peter J Svensson, Anders Själander
Low-molecular-weight heparin (LMWH) is often recommended as a bridging therapy during temporary interruptions in warfarin treatment, despite lack of evidence. The aim of this study was to see whether we could find benefit from LMWH bridging. We studied all planned interruptions of warfarin within the Swedish anticoagulation register Auricula during 2006 to 2011. Low-molecular-weight heparin bridging was compared to nonbridging (control) after propensity score matching. Complications were identified in national clinical registers for 30 days following warfarin cessation, and defined as all-cause mortality, bleeding (intracranial, gastrointestinal, or other), or thrombosis (ischemic stroke or systemic embolism, venous thromboembolism, or myocardial infarction) that was fatal or required hospital care...
January 1, 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/28456008/donor-dependent-and-other-nondefined-factors-have-greater-influence-on-the-hepatic-phenotype-than-the-starting-cell-type-in-induced-pluripotent-stem-cell-derived-hepatocyte-like-cells
#2
James A Heslop, Richard Kia, Christopher S Pridgeon, Rowena L Sison-Young, Triantafillos Liloglou, Mohamed Elmasry, Stephen W Fenwick, John S Mills, Neil R Kitteringham, Chris E Goldring, Bong K Park
Drug-induced liver injury is the greatest cause of post-marketing drug withdrawal; therefore, substantial resources are directed toward triaging potentially dangerous new compounds at all stages of drug development. One of the major factors preventing effective screening of new compounds is the lack of a predictive in vitro model of hepatotoxicity. Primary human hepatocytes offer a metabolically relevant model for which the molecular initiating events of hepatotoxicity can be examined; however, these cells vary greatly between donors and dedifferentiate rapidly in culture...
May 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28446493/hospital-performance-on-percutaneous-coronary-intervention-process-and-outcomes-measures
#3
Philip W Chui, Craig S Parzynski, Brahmajee K Nallamothu, Frederick A Masoudi, Harlan M Krumholz, Jeptha P Curtis
BACKGROUND: The Physician Consortium for Performance Improvement recently proposed percutaneous coronary intervention (PCI)-specific process measures. However, information about hospital performance on these measures and the association of PCI process and outcomes measures are not available. METHODS AND RESULTS: We linked the National Cardiovascular Data Registry (NCDR) CathPCI Registry with Medicare claims data to assess hospital performance on established PCI process measures (aspirin, thienopyridines, and statins on discharge; door-to-balloon time; and referral to cardiac rehabilitation), newly proposed PCI process measures (documentation of contrast dose, glomerular filtration rate, and PCI indication; appropriate indication for elective PCI; and use of embolic protection device), and a composite of all process measures...
April 26, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28415699/the-prognostic-value-of-histological-subtype-in-patients-with-metastatic-bladder-cancer
#4
Cheng Chen, Linkun Hu, Ye Chen, Jianquan Hou
We aim to evaluate the prognostic effect of the histological sub-type in patients with metastatic bladder cancer based on the Surveillance Epidemiology and End Results database. A total of 2634 eligible patients were included. The histological subtypes were: transitional cell carcinoma (TCC; 75.2%); adenocarcinoma (3.3%); squamous cell carcinoma (SQCC; 4.1%); and small cell carcinoma (4.3%). A significant association of adenocarcinoma with better survival outcomes (P < 0.015), and that of SQCC with worse outcomes (P < 0...
April 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28396027/risk-factors-for-community-associated-clostridium-difficile-infection-in-children
#5
Daniel J Adams, Matthew D Eberly, Michael Rajnik, Cade M Nylund
OBJECTIVE: To characterize the medication and other exposures associated with pediatric community-associated Clostridium difficile infections (CA-CDIs). STUDY DESIGN: We performed a case-control study using billing records from the US military health system database. CA-CDI cases included children 1-18 years of age with an outpatient International Classification of Diseases, Ninth Revision, Clinical Modification diagnostic code for Clostridium difficile infection (CDI) from 2001 to 2013...
April 7, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28394192/factors-associated-with-professional-satisfaction-in-primary-care-results-from-euprimecare-project
#6
Carlos Alberto Sanchez-Piedra, Lina Jaruseviciene, Francisco Javier Prado-Galbarro, Ida Liseckiene, Fernando Sánchez-Alonso, Sonia García-Pérez, Antonio Sarria Santamera
BACKGROUND: Given the importance of primary care to healthcare systems and population health, it seems crucial to identify factors that contribute to the quality of primary care. Professional satisfaction has been linked with quality of primary care. Physician dissatisfaction is considered a risk factor for burnout and leaving medicine. OBJECTIVES: This study explored factors associated with professional satisfaction in seven European countries. METHODS: A survey was conducted among primary care physicians...
December 2017: European Journal of General Practice
https://www.readbyqxmd.com/read/28376240/the-development-of-the-physical-fitness-construct-across-childhood
#7
Till Utesch, Dennis Dreiskämper, Bernd Strauss, Roland Naul
The measurement of physical fitness (PF) is an important factor from many different perspectives. PF is a determinant of healthy child development as it is related to several health outcomes. However, existing taxonomies of the construct and frequently used fitness assessments vary concerning their theoretical assumptions and practical implications. From a theoretical perspective, the construct of physical fitness covers a variety of motor domains, such as cardiovascular endurance, strength, coordination, or flexibility (e...
April 4, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28356546/retraction-vol-153-1321-1331-2010
#8
(no author information available yet)
No abstract text is available yet for this article.
April 2017: Plant Physiology
https://www.readbyqxmd.com/read/28347733/neonatal-bcg-vaccination-has-no-effect-on-recurrent-wheeze-in-the-first-year-of-life-a%C3%A2-randomized-clinical-trial
#9
Lisbeth Marianne Thøstesen, Lone Graff Stensballe, Gitte Thybo Pihl, Jesper Kjærgaard, Nina Marie Birk, Thomas Nørrelykke Nissen, Aksel Karl Georg Jensen, Peter Aaby, Annette Wind Olesen, Dorthe Lisbeth Jeppesen, Christine Stabell Benn, Poul-Erik Kofoed
BACKGROUND: Recurrent wheeze (RW) is frequent in childhood. Studies have suggested that BCG vaccination can have nonspecific effects, reducing general nontuberculosis morbidity, including respiratory tract infections and atopic diseases. The mechanisms behind these nonspecific effects of BCG are not fully understood, but a shift from a TH2 to a TH1 response has been suggested as a possible explanation. OBJECTIVE: We hypothesized that BCG at birth would reduce the cumulative incidence of RW during the first year of life...
March 25, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28315263/fluorinated-pet-tracers-for-molecular-imaging-of-%C3%AF-1-receptors-in-the-central-nervous-system
#10
Frauke Weber, Peter Brust, Erik Laurini, Sabrina Pricl, Bernhard Wünsch
At first the role of σ1 receptors in various neurological, psychiatric and neurodegenerative disorders is discussed. In the second part, the principle of positron emission tomography (PET ) is described and the known fluorinated PET tracers for labeling of σ1 receptors are presented. The third part focuses on fluoroalkyl substituted spirocyclic PET tracers, which represent the most promising class of fluorinated PET tracers reported so far. The homologous fluoroalkyl derivatives 12-15 show high σ1 affinity (K i = 0...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28281049/modifiable-and-non-modifiable-characteristics-associated-with-sleep-disturbance-in-oncology-outpatients-during-chemotherapy
#11
Sueann Mark, Janine Cataldo, Anand Dhruva, Steven M Paul, Lee-May Chen, Marilyn J Hammer, Jon D Levine, Fay Wright, Michelle Melisko, Kathryn Lee, Yvette P Conley, Christine Miaskowski
PURPOSE: In a sample of outpatients with breast, gastrointestinal, gynecological, and lung cancer who received at least two cycles of chemotherapy (CTX), the purposes were to evaluate for inter-individual differences in the severity of sleep disturbance and determine which demographic, clinical, and symptom characteristics were associated with initial levels as well as the trajectories of sleep disturbance. METHODS: A total of 1331 patients completed study questionnaires in their homes, at six time points over two cycles of CTX (prior to CTX administration, approximately 1 week after CTX administration, and approximately 2 weeks after CTX administration)...
March 9, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28202099/vibrio-alginolyticus-infections-in-the-usa-1988-2012
#12
K M Jacobs Slifka, A E Newton, B E Mahon
Vibrio alginolyticus causes soft tissue and bloodstream infection; little systematically collected clinical and epidemiological information is available. In the USA, V. alginolyticus infections are reported to the Cholera and Other Vibrio Illness Surveillance system. Using data from 1988 to 2012, we categorised infections using specimen source and exposure history, analysed case characteristics, and calculated incidence rates using US Census Bureau data. Most (96%) of the 1331 V. alginolyticus infections were from coastal states...
May 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28168855/vaccination-of-calves-with-mycobacterium-bovis-bacillus-calmette-guerin-reduces-the-frequency-and-severity-of-lesions-of-bovine-tuberculosis-under-a-natural-transmission-setting-in-ethiopia
#13
G Ameni, K Tafess, A Zewde, T Eguale, M Tilahun, T Hailu, A Sirak, F J Salguero, S Berg, A Aseffa, R G Hewinson, H M Vordermeier
Bovine tuberculosis (bTB) is highly prevalent in intensive dairy farms of the urban "milk-sheds" in Ethiopia, and vaccination could be a cost-effective disease control strategy. In the present study, the efficacy of Bacillus Calmette-Guerin (BCG) to protect against bTB was assessed in Holstein-Friesian calves in a natural transmission setting. Twenty-three 2-week-old calves were subcutaneously vaccinated with BCG Danish SSI strain 1331, and matched 26 calves were injected with placebo. Six weeks later, calves were introduced into a herd of M...
February 6, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28138263/relationship-of-depression-in-participants-with-nonspecific-acute-or-subacute-low-back-pain-and-no-pain-by-age-distribution
#14
Cesar Calvo-Lobo, Juan Manuel Vilar Fernández, Ricardo Becerro-de-Bengoa-Vallejo, Marta Elena Losa-Iglesias, David Rodríguez-Sanz, Patricia Palomo López, Daniel López López
BACKGROUND AND PURPOSE: Nonspecific low back pain (LBP) is the most prevalent musculoskeletal condition in various age ranges and is associated with depression. The aim of this study was to determine the Beck Depression Inventory (BDI) scores in participants with nonspecific LBP and no-pain by age distribution. METHODS: A case-control study was carried out following the Strengthening the Reporting of Observational Studies in Epidemiology criteria. A sample of 332 participants, divided into the following age categories: 19-24 (n=11), 25-39 (n=66), 40-64 (n=90), 65-79 (n=124), and ≥80 (n=41) years was recruited from domiciliary visits and an outpatient clinic...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28116935/-cilostazol-is-effective-and-safe-option-for-the-treatment-of-intermittent-claudication-results-of-the-noclaud-study
#15
Katalin Farkas, Zoltán Járai, Endre Kolossváry
Intermittent claudication can seriously impair the patients' quality of life. Cilostazol was registered in Hungary in 2014. This study aimed to evaluate the efficacy and safety of cilostazol in patients with intermittent claudication. 1405 patients were enrolled to the 6 months, multicenter, non-interventional trial. From the 1331 patients, who completed the study, the data of 674 patients were subjected to efficacy analysis. Pain free and maximal walking distance and the 6 minute walking test improved significantly at 3 months (78...
January 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28078798/systematic-review-with-meta-analysis-rifaximin-is-effective-and-safe-for-the-treatment-of-small-intestine-bacterial-overgrowth
#16
REVIEW
L Gatta, C Scarpignato
BACKGROUND: Small intestinal bacterial overgrowth (SIBO) is a heterogeneous syndrome, characterised by an increased number and/or abnormal type of bacteria in the small bowel. Over the past decades, rifaximin has gained popularity for this indication despite its use is not evidence based. AIM: To perform a systematic review and meta-analysis to summarise evidence about the efficacy and safety of rifaximin to eradicate SIBO in adult patients. METHODS: MEDLINE, EMBASE, CCRCT, Scopus and Web of Science were searched from inception to March 16, 2015 for RCTs and observational studies...
March 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28036104/periodontitis-and-incident-type-2-diabetes-a-prospective-cohort-study
#17
Lewis Winning, Christopher C Patterson, Charlotte E Neville, Frank Kee, Gerard J Linden
OBJECTIVES: The aim of this study was to investigate periodontitis as a risk factor for incident type 2 diabetes mellitus (T2DM) in a group of men aged 58-72 years. METHODS: One thousand three hundred and thirty-one dentate, diabetes-free men in Northern Ireland underwent a detailed periodontal examination during 2001-2003. Follow-up was by bi-annual questionnaire and for those reporting diabetes their general medical practitioner was contacted to validate diabetes type, treatment and diagnosis date...
March 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/27979733/preoperative-metabolic-syndrome-is-predictive-of-significant-gastric-cancer-mortality-after-gastrectomy-the-fujian-prospective-investigation-of-cancer-fiesta-study
#18
Dan Hu, Feng Peng, Xiandong Lin, Gang Chen, Hejun Zhang, Binying Liang, Kaida Ji, Jinxiu Lin, Lin-Feng Chen, Xiongwei Zheng, Wenquan Niu
Metabolic syndrome (MetS) has been shown to be associated with an increased risk of gastric cancer. However, the impact of MetS on gastric cancer mortality remains largely unknown. Here, we prospectively examined the prediction of preoperative MetS for gastric cancer mortality by analyzing a subset of data from the ongoing Fujian prospective investigation of cancer (FIESTA) study. This study was conducted among 3012 patients with gastric cancer who received radical gastrectomy between 2000 and 2010. The latest follow-up was completed in 2015...
February 2017: EBioMedicine
https://www.readbyqxmd.com/read/27979639/the-use-of-high-risk-criteria-in-screening-patients-for-blunt-cerebrovascular-injury-a-survey
#19
Xiao Wu, Ajay Malhotra, Howard P Forman, Diego Nunez, Pina Sanelli
RATIONALE AND OBJECTIVES: Blunt cerebrovascular injury (BCVI) is uncommon, but delayed detection can have disastrous consequences. The Denver criteria are the most commonly used screening criteria. We aim to examine the utilization of screening criteria in the emergency department (ED) of our institution and assess whether patients with risk factors were imaged. MATERIALS AND METHODS: A survey questionnaire was sent out to radiologists in a large academic institution...
December 12, 2016: Academic Radiology
https://www.readbyqxmd.com/read/27940334/obesity-in-middle-age-increases-risk-of-later-heart-failure-in-women-results-from-the-prospective-population-study-of-women-and-h70-studies-in-gothenburg-sweden
#20
Anna-Karin Halldin, Maria Schaufelberger, Bodil Lernfelt, Lena Björck, Annika Rosengren, Lauren Lissner, Cecilia Björkelund
OBJECTIVE: Obesity has been shown to be a risk factor for heart failure (HF), but whether the association varies by age is not understood. The aim was to examine the impact of obesity/overweight on the risk of developing heart failure in women of different ages by analysing prospective data from 2 population studies. METHODS: Data were obtained from the Population Study of Women in Gothenburg and the Gerontologic and Geriatric Population Studies concerning body mass index (BMI) collected in 1980 or later...
May 2017: Journal of Cardiac Failure
keyword
keyword
115149
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"