Paulo Cesar Pereira Dos Santos, Nicole Louise Messina, Roberto Dias de Oliveira, Patricia Vieira da Silva, Marco Antonio Moreira Puga, Margareth Dalcolmo, Glauce Dos Santos, Marcus Vinícius Guimarães de Lacerda, Bruno Araújo Jardim, Fernando Fonseca de Almeida E Val, Nigel Curtis, Jason R Andrews, Julio Croda
BACKGROUND: The effectiveness of BCG vaccine for adult pulmonary tuberculosis remains uncertain. In this study, we aimed to evaluate the effect of vaccination with BCG-Denmark to prevent initial and sustained interferon-γ release assay conversion in Brazilian health-care workers. METHODS: This substudy is a nested randomised controlled trial embedded within the BRACE trial (NCT04327206). Specifically, this substudy enrolled Brazilian health-care workers (aged ≥18 years) from three sites in Brazil (Manaus, Campo Grande, and Rio de Janeiro) irrespective of previously receiving BCG vaccination...
February 26, 2024: Lancet Infectious Diseases