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https://www.readbyqxmd.com/read/29119573/temperature-cycling-during-platelet-cold-storage-improves-in-vivo-recovery-and-survival-in-healthy-volunteers
#1
Jaroslav G Vostal, Monique P Gelderman, Andrey Skripchenko, Fei Xu, Ying Li, Johannah Ryan, Chunrong Cheng, Pam Whitley, Michael Wellington, Sherrie Sawyer, Shalene Hanley, Stephen J Wagner
BACKGROUND: Room temperature (RT) storage of platelets (PLTs) can support bacterial proliferation in contaminated units, which can lead to transfusion-transmitted septic reactions. Cold temperature storage of PLTs could reduce bacterial proliferation but cold exposure produces activation-like changes in PLTs and leads to their rapid clearance from circulation. Cold-induced changes are reversible by warming and periodic rewarming during cold storage (temperature cycling [TC]) has been proposed to alleviate cold-induced reduction in PLT circulation...
November 8, 2017: Transfusion
https://www.readbyqxmd.com/read/29115004/evaluation-of-a-multifactorial-approach-to-reduce-the-prevalence-of-pressure-injuries-in-regional-australian-acute-inpatient-care-settings
#2
Sarah K Smith, Samantha E Ashby, Lynette Thomas, Felicity Williams
The aim of the study was to compare the changes in the prevalence of pressure injuries from 2008 to 2014 in relation to staff behaviour in acute/subacute inpatient care settings. In 2008, the large regional health district Hunter New England Local Health District implemented an initiative called the Crystal Model which resulted in changes in their policy and an e-learning education program for all nursing staff. A retrospective cross sectional study compared data from the 2008, 2010 and 2014 point prevalence surveys of PI in acute services...
November 7, 2017: International Wound Journal
https://www.readbyqxmd.com/read/29101441/drivers-of-hospital-costs-in-the-self-pay-facelift-rhytidectomy-patient-analysis-of-hospital-resource-utilization-in-1890-patients
#3
Anmol Chattha, Alexandra Bucknor, David Chi, Klaas Ultee, Austin D Chen, Samuel J Lin
INTRODUCTION: Rhytidectomy is one of the most commonly performed cosmetic procedures by plastic surgeons. Increasing attention to the development of a high-value, low-cost healthcare system is a priority in the USA. This study aims to analyze specific patient and hospital factors affecting the cost of this procedure. METHODS: We conducted a retrospective cohort study of self-pay patients over the age of 18 who underwent rhytidectomy using the Healthcare Utilization Cost Project National Inpatient Sample database between 2013 and 2014...
November 3, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29075859/transabdominal-pre-peritoneal-versus-open-repair-for-primary-unilateral-inguinal-hernia-a-meta-analysis
#4
James J Wu, Joshua A Way, Guy D Eslick, Michael R Cox
BACKGROUND: Recent NICE guidelines recommend open surgical approaches for the treatment of primary unilateral inguinal hernias. However, many surgeons perform a laparoscopic approach based on the advantages of less post-operative pain and faster recovery. Our aim was to examine current evidence comparing transabdominal pre-peritoneal (TAPP) laparoscopic repair and open surgical repair for primary inguinal hernias. METHODS: A systematic search of six electronic databases was conducted for randomised controlled trials (RCTs) comparing TAPP and open repair for primary unilateral inguinal hernia...
October 11, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29069024/risk-factors-of-central-lymph-node-metastasis-of-papillary-thyroid-carcinoma-a-single-center-retrospective-analysis-of-3273-cases
#5
Wen Liu, Ruochuan Cheng, Yanjun Su, Chang Diao, Jun Qian, Jianming Zhang, Yunhai Ma, Yinxia Fan
Due to the lack of an accurate preoperative diagnostic method of central lymph node metastasis (CLNM) of papillary thyroid cancer (PTC), the prophylaxis of central lymph node dissection remains controversial. The present study investigated the clinicopathological features of PTC patients and the risk factors of CLNM. The clinicopathological features of PTC patients with respect to sex, age, initial symptoms, observation, tumor diameter, multifocality, extrathyroidal invasion, and pathological data combined with other thyroid diseases, were analyzed retrospectively...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29063057/clinical-epidemiological-survey-of-gallbladder-carcinoma-in-northwestern-china-2009-2013-2379-cases-in-17-centers
#6
Hao-Xin Shen, Hu-Wei Song, Xin-Jian Xu, Zuo-Yi Jiao, Zhen-Yu Ti, Zhao-Yu Li, Bin Ren, Chen Chen, Li Ma, Ya-Ling Zhao, Guan-Jun Zhang, Jian-Cang Ma, Xi-Lin Geng, Xiao-Di Zhang, Jing-Sen Shi, Lin Wang, Zhi-Min Geng
OBJECTIVE: To analyze the clinical epidemiological characteristics of patients with gallbladder carcinoma recruited from 17 hospitals in five northwestern provinces of China (Shaanxi Province, Gansu Province, Qinghai Province, Ningxia Hui Autonomous Region, and Xinjiang Uygur Autonomous Region) from 2009 to 2013, and to summarize the clinical diagnosis and treatment data of gallbladder carcinoma. METHODS: Clinical information of 2379 patients with gallbladder carcinoma from 17 hospitals in five northwestern provinces of China was retrospectively collected and analyzed using the "Questionnaire for Gallbladder Carcinoma Patients in Northwestern Area of China...
March 25, 2017: Chronic Dis Transl Med
https://www.readbyqxmd.com/read/28990668/population-panmixia-and-demographic-expansion-of-a-highly-piscivorous-marine-fish-scomberomorus-niphonius
#7
S Kitada, K Nakajima, K Hamasaki
Population structure and demographic history of the Japanese Spanish mackerel Scomberomorus niphonius a highly piscivorous and migratory marine fish, were assessed using mitochondrial DNA control region sequences (n = 720) and microsatellite genotypes at five loci (n = 1331) for samples collected on Japanese coasts from 2001 to 2010. The population structure was panmictic and the haplotype and allele frequencies were temporally stable even during the recent recovery process. Demographic expansion was strongly supported throughout the Pleistocene, suggesting that the oscillating glacial and interglacial climate conditions in the Pleistocene had no substantial impact on the demographic history of S...
October 9, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28967416/systematic-review-and-meta-analysis-of-chordal-replacement-versus-leaflet-resection-for-posterior-mitral-leaflet-prolapse
#8
Amine Mazine, Jan O Friedrich, Rashmi Nedadur, Subodh Verma, Maral Ouzounian, Peter Jüni, John D Puskas, Bobby Yanagawa
OBJECTIVES: To compare outcomes of chordal replacement versus leaflet resection techniques for repair of isolated posterior mitral leaflet prolapse. METHODS: We searched MEDLINE and EMBASE databases for studies that compared chordal replacement ("neo-chord" group) versus leaflet resection ("resection" group) techniques for the treatment of posterior mitral leaflet prolapse. Data were extracted by 2 independent investigators and subjected to a meta-analysis using a random-effects model...
August 24, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28941918/impact-of-lesion-visibility-on-transrectal-ultrasound-on-the-prediction-of-clinically-significant-prostate-cancer-gleason-score-%C3%A2-3-4-with-trus-mri-fusion-biopsy
#9
Kirema Garcia-Reyes, Hao G Nguyen, Ronald J Zagoria, Katsuto Shinohara, Peter R Carroll, Spencer C Behr, Antonio C Westphalen
PURPOSE: The purpose of this study was to estimate the impact of lesion visibility with TRUS on the prediction of CS-PCA with TRUS-MRI fusion biopsy. MATERIALS AND METHODS: This HIPAA-compliant, IRB-approved retrospective study included 178 men (age, 64.7 years; PSA, 8.9 ng/ml) who underwent TRUS-MRI fusion biopsy from January/2013 to September/2016. Visible lesions on MRI were those assigned a PI-RADS v2 score ≥ 3. TRUS was positive when a hypoechoic lesion was identified...
September 20, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28936594/transcatheter-aortic-valve-replacement-outcomes-indications-complications-and-innovations
#10
REVIEW
Michael N Young, Ignacio Inglessis
Transcatheter aortic valve replacement (TAVR) has become the standard of care for the treatment of severe aortic stenosis in individuals who are at prohibitive surgical risk and presents a viable alternative to surgery in selected patients who are at high operative risk. To date, outcomes from the PARTNER (Placement of AoRtic TraNscathetER Valve) and Medtronic CoreValve® US Pivotal trials continue to show the benefits of TAVR in these high-risk subgroups out to 5 and 3 years, respectively (as reported by Mack et al...
September 22, 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28898779/ozone-cathode-microbial-desalination-cell-an-innovative-option-to-bioelectricity-generation-and-water-desalination
#11
Abdolmajid Gholizadeh, Ali Asghar Ebrahimi, Mohammad Hossein Salmani, Mohammad Hassan Ehrampoush
Microbial desalination cell (MDC) is a new approach of water desalination methods, which is based on ionic species removal from water in proportion to the electric current generated by bacteria. However, the low current generation and insufficient deionization in this technology have created challenges to improve the process. Here, the performance of MDC using ozone as a new electron acceptor (O3-MDC) was evaluated versus another operated independently with oxygen (O2-MDC). Results showed the maximum open-circuit voltages of 628 and 1331 mV for 20 g L(-1) NaCl desalination in O2-MDC and O3-MDC, respectively...
September 4, 2017: Chemosphere
https://www.readbyqxmd.com/read/28806786/an-economic-evaluation-of-vector-control-in-the-age-of-a-dengue-vaccine
#12
Christopher Fitzpatrick, Alexander Haines, Mathieu Bangert, Andrew Farlow, Janet Hemingway, Raman Velayudhan
INTRODUCTION: Dengue is a rapidly emerging vector-borne Neglected Tropical Disease, with a 30-fold increase in the number of cases reported since 1960. The economic cost of the illness is measured in the billions of dollars annually. Environmental change and unplanned urbanization are conspiring to raise the health and economic cost even further beyond the reach of health systems and households. The health-sector response has depended in large part on control of the Aedes aegypti and Ae...
August 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28792750/combined-ab-initio-kinetic-modeling-and-shock-tube-study-of-the-thermal-decomposition-of-ethyl-formate
#13
Hongbo Ning, Junjun Wu, Liuhao Ma, Wei Ren, David F Davidson, Ronald K Hanson
The potential energy surfaces (PESs) and reaction rate constants of the unimolecular decomposition of ethyl formate (EF) were investigated using high-precision theoretical methods at the CCSD(T)/CBS(T-Q)//M06-2X/6-311++G(d,p) level of theory. The calculated PESs of EF dissociation and molecular decomposition reactions indicate that the intramolecular H-shift to produce formic acid and ethylene is the dominant decomposition pathway. A detailed chemical kinetic mechanism for EF pyrolysis was constructed by incorporating the important reactions of EF and its radicals into an existing mechanism previously developed for small methyl esters...
August 23, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28791694/improved-prognosis-of-young-patients-with-breast-cancer-undergoing-breast-conserving-surgery
#14
E Botteri, P Veronesi, J Vila, N Rotmensz, V Galimberti, M V Thomazini, G Viale, R Orecchia, A Goldhirsch, O Gentilini
BACKGROUND: The aim of the present study was to evaluate how breast cancer prognosis has evolved over time in young women treated with breast-conserving surgery (BCS). METHODS: Data from patients younger than 40 years who had BCS and whole-breast radiotherapy in a single cancer centre between 1997 and 2010 were analysed. The patients were followed until 2016. Endpoints were local recurrence, any breast cancer-related event and death from any cause. RESULTS: A total of 1331 patients were included in the study...
August 9, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28774269/the-association-between-bacillus-calmette-gu%C3%A3-rin-vaccination-1331-ssi-skin-reaction-and-subsequent-scar-development-in-infants
#15
RANDOMIZED CONTROLLED TRIAL
Nina Marie Birk, Thomas Nørrelykke Nissen, Monica Ladekarl, Vera Zingmark, Jesper Kjærgaard, Trine Mølbæk Jensen, Signe Kjeldgaard Jensen, Lisbeth Marianne Thøstesen, Poul-Erik Kofoed, Lone Graff Stensballe, Andreas Andersen, Ole Pryds, Susanne Dam Nielsen, Christine Stabell Benn, Dorthe Lisbeth Jeppesen
BACKGROUND: The Bacillus Calmette-Guérin vaccine (BCG) against tuberculosis is administered intradermally, and vaccination is often followed by a scar at the injection site. Among BCG-vaccinated individuals, having a scar has been associated with lower mortality. We aimed to examine the impact of vaccination technique for scarring in a high income setting, by assessing the associations between the post injection reaction, the wheal size, and the probability of developing a scar, and scar size...
August 3, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28770403/route-of-feeding-as-a-proxy-for-dysphagia-after-stroke-and-the-effect-of-transdermal-glyceryl-trinitrate-data-from-the-efficacy-of-nitric-oxide-in-stroke-randomised-controlled-trial
#16
Lisa J Woodhouse, Polly Scutt, Shaheen Hamdy, David G Smithard, David L Cohen, Christine Roffe, Daniel Bereczki, Eivind Berge, Christopher F Bladin, Valeria Caso, Hanne K Christensen, Rónán Collins, Anna Czlonkowska, Asita de Silva, Anwar Etribi, Ann-Charlotte Laska, George Ntaios, Serefnur Ozturk, Stephen J Phillips, Kameshwar Prasad, Szabolcs Szatmari, Nikola Sprigg, Philip M Bath
Post-stroke dysphagia is common, associated with poor outcome and often requires non-oral feeding/fluids. The relationship between route of feeding and outcome, as well as treatment with glyceryl trinitrate (GTN), was studied prospectively. The Efficacy of Nitric Oxide in Stroke (ENOS) trial assessed transdermal GTN (5 mg versus none for 7 days) in 4011 patients with acute stroke and high blood pressure. Feeding route (oral = normal or soft diet; non-oral = nasogastric tube, percutaneous endoscopic gastrostomy tube, parenteral fluids, no fluids) was assessed at baseline and day 7...
August 2, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/28754791/association-analysis-of-the-mhc-in-lupus-nephritis
#17
Ricong Xu, Qibin Li, Rongjun Liu, Juan Shen, Ming Li, Minghui Zhao, Meng Wang, Qijun Liao, Haiping Mao, Zhijian Li, Na Zhou, Peiran Yin, Yue Li, Xueqing Tang, Tian Wu, Zhong Zhong, Yan Wang, Zhen Ai, Ou Wang, Nan Chen, Xiaoqin Yang, Junbin Fang, Ping Fu, Jieruo Gu, Kun Ye, Jian Chen, Lie Dai, Huafeng Liu, Zhangsuo Liu, Yunhua Liao, Jianxin Wan, Guohua Ding, Jinghong Zhao, Hao Zhang, Shuxia Fu, Liangdan Sun, Xuejun Zhang, Huanming Yang, Jian Wang, Jun Wang, Jianjun Liu, Yingrui Li, Xueqing Yu
Lupus nephritis (LN) is one of the most prevalent and serious complications of SLE, with significant effects on patient and renal survival. Although a large number of genetic variants associated with SLE have been identified, biomarkers that correlate with LN are extremely limited. In this study, we performed a comprehensive sequencing analysis of the whole MHC region in 1331 patients with LN and 1296 healthy controls and validated the independent associations in another 950 patients with LN and 1000 controls...
November 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28748914/association-of-bone-turnover-markers-with-glucose-metabolism-in-chinese-population
#18
Jie Wang, Dan-Dan Yan, Xu-Hong Hou, Yu-Qian Bao, Cheng Hu, Zhen-Lin Zhang, Wei-Ping Jia
The association between type 2 diabetes (T2DM) and bone metabolism has been discussed previously but is controversial. In this study we aimed to evaluate the association of bone turnover markers with glucose metabolism in Chinese population, in which 919 males and 4171 postmenopausal females in a region of Shanghai were recruited. Anthropometric and biochemical traits related to glucose and bone metabolism were analyzed. Participants were classified according to their glucose tolerance as normal glucose tolerance (NGT), impaired glucose regulation (IGR) or T2DM...
July 27, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28748500/digital-droplet-pcr-ddpcr-for-the-detection-and-quantification-of-hpv-16-18-33-and-45%C3%A2-a-short-report
#19
Gabriella Lillsunde Larsson, Gisela Helenius
PURPOSE: Human papilloma virus (HPV) infection is associated with several anogenital malignancies. Here, we set out to evaluate digital droplet PCR (ddPCR) as a tool for HPV 16, 18, 33 and 45 viral load quantification and, in addition, to compare the efficacy of the ddPCR assay for HPV 16 detection with that of quantitative real-time PCR (qPCR). METHODS: Clinical samples, positive for HPV genotypes 16, 18, 33 and 45 were analyzed for viral load using ddPCR. Sample DNA was cleaved before droplet generation and PCR...
October 2017: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/28648850/complete-genome-analysis-of-dengue-virus-type-3-isolated-from-the-2013-dengue-outbreak-in-yunnan-china
#20
Xiaodan Wang, Dehong Ma, Xinwei Huang, Lihua Li, Duo Li, Yujiao Zhao, Lijuan Qiu, Yue Pan, Junying Chen, Juemin Xi, Xiyun Shan, Qiangming Sun
In the past few decades, dengue has spread rapidly and is an emerging disease in China. An unexpected dengue outbreak occurred in Xishuangbanna, Yunnan, China, resulting in 1331 patients in 2013. In order to obtain the complete genome information and perform mutation and evolutionary analysis of causative agent related to this largest outbreak of dengue fever. The viruses were isolated by cell culture and evaluated by genome sequence analysis. Phylogenetic trees were then constructed by Neighbor-Joining methods (MEGA6...
June 23, 2017: Virus Research
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