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https://www.readbyqxmd.com/read/28108860/early-cardioversion-in-atrial-fibrillation-earlier-is-better-but-not-always-and-maybe-not-immediately
#1
REVIEW
Paloma G Piña, Alexandru B Chicos
Atrial fibrillation (AF) is the most common cardiac arrhythmia in humans. One of its important features is the tendency to become more persistent over time, even in the absence of underlying progressive heart disease. Conversion and maintenance of sinus rhythm by pharmacological or electrical methods become increasingly difficult the longer the arrhythmia persists. Electrical, mechanical, structural, and autonomic remodeling processes have been implicated in the mechanisms of AF initiation, perpetuation, and progression...
January 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/28108826/the-sacral-parasympathetic-system-is-actually-sympathetic-and-other-updates-on-recent-autonomic-research
#2
EDITORIAL
Mitchell G Miglis, Srikanth Muppidi
No abstract text is available yet for this article.
January 20, 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/28108812/fackel-interacts-with-gibberellic-acid-signaling-and-vernalization-to-mediate-flowering-in-arabidopsis
#3
Bingyao Huang, Pingping Qian, Na Gao, Jie Shen, Suiwen Hou
Fackel (FK) is involved in the flowering of Arabidopsis mainly via the gibberellin pathway and vernalization pathway. This new function of FK is partially dependent on the FLOWERING LOCUS C ( FLC ). A common transitional process from vegetative stage to reproductive stage exists in higher plants during their life cycle. The initiation of flower bud differentiation, which plays a key role in the reproductive phase, is affected by both external environmental and internal regulatory factors. In this study, we showed that the Arabidopsis weak mutant allele fk-J3158, impaired in the FACKEL (FK) gene, which encodes a C-14 reductase involved in sterol biosynthesis, had a long life cycle and delayed flowering time in different photoperiods...
January 20, 2017: Planta
https://www.readbyqxmd.com/read/28108749/deinococcus-malanensis-sp-nov-isolated-from-radiation-polluted-soil
#4
Jing Zhu, Shan-Hui Li, Qi-Yong Tang, Min Chu, Wei Wang, Nimaichand Salam, Li Li, Wael N Hozzein, Zhi-Dong Zhang, Wen-Jun Li
A Gram-staining positive, non-spore forming, short rod-shaped and coccus-shaped, non-motile, pink-colored, gamma- and UV-resistant strain, designated T93(T) was isolated from soil of Malan area in Xinjiang Uyghur Autonomous Region, Northwest China. The taxonomic position of the new isolate was determined using a polyphasic approach. Strain T93(T) shared the highest 16 S rRNA gene sequence similarity with Deinococcus deserti VCD115(T) (97.54%). The genomic DNA G+C content of the isolate T93(T) was 61.7 mol%...
January 20, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28108546/automatic-health-record-review-to-help-prioritize-gravely-ill-social-security-disability-applicants
#5
Kenneth Abbott, Yen-Yi Ho, Jennifer Erickson
OBJECTIVE: Every year, thousands of patients die waiting for disability benefits from the Social Security Administration. Some qualify for expedited service under the Compassionate Allowance (CAL) initiative, but CAL software focuses exclusively on information from a single form field. This paper describes the development of a supplemental process for identifying some overlooked but gravely ill applicants, through automatic annotation of health records accompanying new claims. We explore improved prioritization instead of fully autonomous claims approval...
January 20, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28108010/from-avoidance-to-approach-the-influence-of-threat-of-shock-on-reward-based-decision-making
#6
Florian Bublatzky, Georg W Alpers, Andre Pittig
Potential threat can prime defensive responding and avoidance behavior, which may result in the loss of rewards. When aversive consequences do not occur, avoidance should, thus, be quickly overcome in healthy individuals. This study examined the impact of threat anticipation on reward-based decisions. Sixty-five participants completed a decision-making task in which they had to choose between high- and low-reward options. To model an approach-avoidance conflict, the high-reward option was contingent with a threat-of-shock cue; the low-reward option was contingent with a safety cue...
January 10, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28107890/affective-impairment-in-chronic-low-blood-pressure
#7
Stefan Duschek, Alexandra Hoffmann, Gustavo A Reyes Del Paso
OBJECTIVE: Physical complaints such as faintness, dizziness, cold limbs and headaches have been well-established in chronic low blood pressure (hypotension). This study investigated the occurrence of adverse emotional states and the symptoms of depression in this condition. As autonomic dysregulation, particularly diminished sympathetic tone, is believed to be involved in the etiology of hypotension, the impact of different facets of autonomic cardiovascular control on mood and depressive symptoms was also explored...
February 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28107591/the-role-of-autonomic-dysfunction-in-predicting-one-year-mortality-after-liver-transplantation
#8
Kuang-Cheng Chan, Jia-Rong Yeh, Wei-Zen Sun
BACKGROUND & AIMS: Model for end-stage liver disease (MELD) score has been extensively used to prioritize patients for liver transplantation and determine their prognosis, but with limited predictive value. Autonomic dysfunction may correlate with increased mortality after liver transplant. In this study, two autonomic biomarkers, complexity and deceleration capacity, were added to the predicting model for one-year mortality after liver transplantation. METHODS: Thirty patients with end-stage liver diseases awaiting liver transplantation were included...
January 20, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28107340/association-of-diabetes-related-complications-with-heart-rate-variability-among-a-diabetic-population-in-the-uae
#9
Ahsan H Khandoker, Haitham M Al-Angari, Kinda Khalaf, Sungmun Lee, Wael Almahmeed, Habiba S Al Safar, Herbert F Jelinek
Microvascular, macrovascular and neurological complications are the key causes of morbidity and mortality among type II diabetes mellitus (T2DM) patients. The aim of this study was to investigate the alterations of cardiac autonomic function of diabetic patients in relation to three types of diabetes-related complications. ECG recordings were collected and analyzed from 169 T2DM patients in supine position who were diagnosed with nephropathy (n = 55), peripheral neuropathy (n = 64) and retinopathy (n = 106) at two hospitals in the UAE...
2017: PloS One
https://www.readbyqxmd.com/read/28107120/treatment-of-diabetic-autonomic-neuropathy-in-older-adults-with-diabetes-mellitus
#10
Nataliya Scheinberg, Rebecca L Salbu, Gayotri Goswami, Kenneth Cohen
OBJECTIVE: To review the epidemiology, pathophysiology, screening and diagnosis, and optimal treatment of diabetic autonomic neuropathy (DAN) and its implications in older adults. DATA SOURCES, STUDY SELECTION, DATA EXTRACTION, DATA SYNTHESIS: A search of PubMed using the Mesh terms "diabetes," "type 1," "insulin-dependent," "T1DM," and "diabetic autonomic neuropathy" was performed to find relevant primary literature. Additional search terms "epidemiology," "geriatric," and "risk" were employed...
November 1, 2016: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/28106746/fisheye-based-method-for-gps-localization-improvement-in-unknown-semi-obstructed-areas
#11
Julien Moreau, Sébastien Ambellouis, Yassine Ruichek
A precise GNSS (Global Navigation Satellite System) localization is vital for autonomous road vehicles, especially in cluttered or urban environments where satellites are occluded, preventing accurate positioning. We propose to fuse GPS (Global Positioning System) data with fisheye stereovision to face this problem independently to additional data, possibly outdated, unavailable, and needing correlation with reality. Our stereoscope is sky-facing with 360° × 180° fisheye cameras to observe surrounding obstacles...
January 17, 2017: Sensors
https://www.readbyqxmd.com/read/28106579/the-shifting-sands-of-nursing-informatics-education-from-content-to-connectivity
#12
Michelle Honey, Paula Procter
This chapter considers the development of nurse education over the past 50 years and ventures a view towards 2020. A link will be made to the introduction of informatics to nursing curricula. It is clear when looking over the recent history of nurse education that it has moved from a medical model and content driven apprentice mode to that of a reflective agile professional mode where autonomous practice allows for collaboration in care and connectivity between health professionals. Parallel to these pedagogical changes are the introduction of informatics across healthcare, starting with computer skills and moving through information management to decision support...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28106066/the-psychosis-spectrum-in-parkinson-disease
#13
REVIEW
Dominic H Ffytche, Byron Creese, Marios Politis, K Ray Chaudhuri, Daniel Weintraub, Clive Ballard, Dag Aarsland
In 2007, the clinical and research profile of illusions, hallucinations, delusions and related symptoms in Parkinson disease (PD) was raised with the publication of a consensus definition of PD psychosis. Symptoms that were previously deemed benign and clinically insignificant were incorporated into a continuum of severity, leading to the rapid expansion of literature focusing on clinical aspects, mechanisms and treatment. Here, we review this literature and the evolving view of PD psychosis. Key topics include the prospective risk of dementia in individuals with PD psychosis, and the causal and modifying effects of PD medication...
January 20, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28106018/cardioneuroablation-in-the-treatment-of-neurally-mediated-reflex-syncope-a-review-of-the-current-literature
#14
Tolga Aksu, Tümer Erdem Güler, Serdar Bozyel, Kazım Serhan Özcan, Kıvanç Yalın, Ferit Onur Mutluer
OBJECTIVE: An imbalance between parasympathetic and sympathetic tone is a main cause of neurally mediated reflex syncope (NMRS). These patients may be very symptomatic and the condition may require cardiac pacemaker implantation. Cardioneuroablation (CNA) is a relatively novel technique based on radiofrequency ablation of vagal ganglia that can be used in treatment of NMRS. The aim of this analysis was to compare potential role of CNA in patients with NMRS. METHODS: In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement, literature search was conducted using the keywords "cardioneuroablation," "vagal denervation," "reflex syncope," "vagal ablation," and "ganglionic plexi ablation...
December 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28105785/micromotors-spontaneously-neutralize-gastric-acid-for-ph-responsive-payload-release
#15
Jinxing Li, Pavimol Angsantikul, Wenjuan Liu, Berta Esteban-Fernández de Ávila, Soracha Thamphiwatana, Mingli Xu, Elodie Sandraz, Xiaolei Wang, Jorge Delezuk, Weiwei Gao, Liangfang Zhang, Joseph Wang
The highly acidic gastric environment creates a physiological barrier for using therapeutic drugs in the stomach. While proton pump inhibitors have been widely used for blocking acid-producing enzymes, this approach can cause various adverse effects. Reported herein is a new microdevice, consisting of magnesium-based micromotors which can autonomously and temporally neutralize gastric acid through efficient chemical propulsion in the gastric fluid by rapidly depleting the localized protons. Coating these micromotors with a cargo-containing pH-responsive polymer layer leads to autonomous release of the encapsulated payload upon gastric-acid neutralization by the motors...
January 20, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28105568/koumine-exhibits-anxiolytic-properties-without-inducing-adverse-neurological-effects-on-functional-observation-battery-open-field-and-vogel-conflict-tests-in-rodents
#16
Chao-Jie Chen, Zhi-Feng Zhong, Zhi-Ming Xin, Long-Hui Hong, Yan-Ping Su, Chang-Xi Yu
Koumine, an active alkaloid of neurotoxic plant Gelsemium, has been focused on its therapeutic uses, especially in central nervous system. Nevertheless, less is known about the neurological effects of koumine, which hampers its potential therapeutic exploitation. Moreover, as the anxiolytic potential of Gelsemium has raised many critical issues, its active principles on the anxiolytic and other neurological effects need to be further investigated. Here, we used functional observation battery (FOB) of mice to systematically measure the neurological effects of koumine at the effective doses, and then further confirmed its anxiolytic properties in open-field test (OFT) of mice and Vogel conflict test (VCT) of rats...
January 19, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28104909/selective-neuronal-vulnerability-in-parkinson-disease
#17
D James Surmeier, José A Obeso, Glenda M Halliday
Intracellular α-synuclein (α-syn)-rich protein aggregates called Lewy pathology (LP) and neuronal death are commonly found in the brains of patients with clinical Parkinson disease (cPD). It is widely believed that LP appears early in the disease and spreads in synaptically coupled brain networks, driving neuronal dysfunction and death. However, post-mortem analysis of human brains and connectome-mapping studies show that the pattern of LP in cPD is not consistent with this simple model, arguing that, if LP propagates in cPD, it must be gated by cell- or region-autonomous mechanisms...
January 20, 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28104294/rodent-models-of-depression-cardiovascular-comorbidity-bridging-the-known-to-the-new
#18
REVIEW
Luca Carnevali, Nicola Montano, Rosario Statello, Andrea Sgoifo
Numerous epidemiological studies have demonstrated a close and bidirectional association between depression and cardiovascular disorders (CVD). This comorbidity places a significant burden on individuals and the healthcare system. Not surprisingly, in the last two decades preclinical research in the field of depression and CVD has rapidly progressed. Multiple studies have demonstrated that aspects of human depression/cardiovascular comorbidity can be modeled in rodents exposed to chronic stress paradigms and that a depressive-like syndrome can be induced in rodent models of CVD...
January 16, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28104072/autonomic-tone-and-atrial-fibrillation-a%C3%A2-double-edged-sword
#19
EDITORIAL
Jeffrey J Goldberger, Raul D Mitrani
No abstract text is available yet for this article.
January 24, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28104071/cardiac-autonomic-dysfunction-and-incidence-of-atrial-fibrillation-results-from-20-years-follow-up
#20
Sunil K Agarwal, Faye L Norby, Eric A Whitsel, Elsayed Z Soliman, Lin Y Chen, Laura R Loehr, Valentin Fuster, Gerardo Heiss, Josef Coresh, Alvaro Alonso
BACKGROUND: Cardiac autonomic perturbations frequently antecede onset of paroxysmal atrial fibrillation (AF). Interventions that influence autonomic inputs to myocardium may prevent AF. However, whether low heart rate or heart rate variability (HRV), which are noninvasive measures of cardiac autonomic dysfunction, are associated with AF incidence is unclear. OBJECTIVES: This study sought to study the association between HRV and risk of AF. METHODS: This study included 11,715 middle-aged adults in the ARIC (Atherosclerosis Risk In Communities) cohort with heart rate and HRV measures obtained from 2-min electrocardiogram recordings performed at baseline (1987 to 1989)...
January 24, 2017: Journal of the American College of Cardiology
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