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R M Bijlsma, R H P Wouters, H Wessels, A M May, M G E M Ausems, E E Voest, A L Bredenoord
OBJECTIVE: Next-generation sequencing (NGS) is increasingly being employed in the context of personalized cancer treatment. Anticipating unsolicited findings that may arise during a NGS procedure is a key consideration; however, little is known about cancer patients' intentions, needs, and preferences concerning the return of unsolicited findings. METHODS: A qualitative design using individual semi-structured interviews with 24 cancer patients was utilized to explore patients' decisions on whether to receive unsolicited findings from NGS...
February 22, 2018: Psycho-oncology
Phillip R Fischer, Imad Jarjour, Erin L Marriott, Debra Weese-Mayer, Gisela Chelimsky
No abstract text is available yet for this article.
February 22, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
Nanduri R Prabhakar, Ying-Jie Peng, Guoxiang Yuan, Jayasri Nanduri
Sleep apnea is a prevalent respiratory disease characterized by periodic cessation of breathing during sleep causing intermittent hypoxia (IH). Sleep apnea patients and rodents exposed to IH exhibit elevated sympathetic nerve activity and hypertension. A heightened carotid body (CB) chemoreflex has been implicated in causing autonomic abnormalities in IH-treated rodents and in sleep apnea patients. The purpose of this article is to review the emerging evidence showing that interactions between reactive oxygen species (ROS) and gaseous transmitters as a mechanism cause hyperactive CB by IH...
February 22, 2018: Cell and Tissue Research
Heidi L Lujan, Anne Tonson, Robert W Wiseman, Stephen E DiCarlo
Spinal cord injury (SCI) resulting in tetraplegia is a devastating, life-changing insult causing paralysis and sensory impairment as well as distinct autonomic dysfunction that triggers compromised cardiovascular, bowel, bladder and sexual activity. Life becomes a battle for independence as even routine bodily functions and the smallest activity of daily living become a major challenge. Accordingly, there is a critical need for a chronic pre-clinical model of tetraplegia. This report addresses this critical need by comparing, for the first time, resting, reflex and stress-induced cardiovascular, autonomic and hormonal responses each week for 4 weeks in 12 sham-operated intact rats and 12 rats with chronic, complete C6-7 spinal cord transection...
February 22, 2018: Journal of Applied Physiology
Camila Antia, Leah Persad, Ali Alikhan
Varicella zoster virus (VZV) is an exclusively human, double-stranded DNA virus. Primary infection causes varicella (chickenpox); later the virus becomes dormant in the dorsal root, cranial nerve, and autonomic ganglia along the entire span of the nervous system, retaining the capacity to reactivate and cause a variety of dermal and neurological complications. Recently there has been increasing recognition, both clinically and epidemiologically, of the relationship between VZV and subsequent strokes. Herein, we describe a case of a previously healthy individual with reactivation of VZV causing herpes zoster opthtalmicus along with devastating multifocal vasculopathy...
July 15, 2017: Dermatology Online Journal
Yu Shui-Lan, Deng Ji-Guang, Xu Shao-Ren, Jiang Zhi-Hua
OBJECTIVE: To understand the schistosomiasis epidemic and control history in Jingxi City, so as to provide the evidence for improving the future work. METHODS: The data of schistosomiasis prevention and control work were collected and analyzed comprehensively in Jingxi City from 1956-2015. RESULTS: From 1956, the schistosomiasis prevention and control work carried out, and in 1985, Jingxi City reached the standard of schistosomiasis transmission interrupted and no local schistosome infected residents and livestock were found for 36 years...
March 10, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
Yu Qing, Han Shuai, Wang Qiang, Xue Jing-Bo
OBJECTIVE: To report the integrated progress of the hydatid disease information management system, and to provide the reference for further system improvements by analysis of results on simulation test feedback. METHODS: The work of institutional code matching by collecting fundamental and integrated information of the system in epidemic areas of hydatid disease was carried out, and professional control agencies were selected to carry out the simulation test. RESULTS: The results of agencies code matching at stage indicated the average completion rate was 94...
June 8, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
Zhang Li-Juan, Xu Zhi-Min, Qian Ying-Jun, Dang Hui, Lü Shan, Xu Jing, Li Shi-Zhu, Zhou Xiao-Nong
This report presents the endemic status of schistosomiasis in the People's Republic of China at national level in 2016, and analyzes the data collected from the national schistosomiasis prevention and control system and 454 national schistosomiasis surveillance sites. Among the 12 provinces (municipality and autonomous region) of endemic of schistosomiasis japonica in P. R. China, 5 provinces (municipality and autonomous region), i.e., Shanghai, Zhejiang, Fujian, Guangdong and Guangxi, had achieved elimination, and 7 provinces of Sichuan, Yunnan, Jiangsu, Hubei, Anhui, Jiangxi and Hunan had achieved transmission control by the end of 2016...
December 28, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
Wu Yang-Yang, Liao Lin, Lin Fa-Quan
Food-borne parasitic diseases have become a public health problem for social economy and health care. In this paper, the epidemic situation of major food-borne parasitic diseases in Guangxi Zhuang Autonomous Region, such as toxoplasmosis and clonorchiasis, are reviewed, and the countermeasures of prevention and control are put forward.
July 27, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
Gao Shu-Feng, Han Xiu-Min, Zhang Xue-Fei, Wang Yong-Shun, Wang Wei, Guo Ya-Min, Li Yong-Shou
OBJECTIVE: To determine the susceptibility genes and resistance genes in HLA-DRB1 alleles in Tibetan patients with cystic and alveolar hydatid diseases, so as to provide the references for the research of the genetic characteristics and infection mechanism of Tibetan hydatid diseases. METHODS: The case control method was applied. The Tibetan patients with cystic and alveolar hydatid diseases (63 and 73 cases respectively) in Yushu and Guoluo Tibetan Autonomous Prefecture, and unrelated healthy people (60 cases) in this area were selected as the study subjects...
October 23, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
Wang Jun-Yun, Gao Chun-Hua
Kala-azar was once transmitted in the northern area of the Yangtze River in China, including 16 provinces (cities or autonomous regions). Through the great continuing prevention and control effort, this disease has been effectively controlled in the most of endemic areas. However, because the epidemic factors of the disease are complex, this disease still transmits or sporadically occurs in the western part of China, including 60 counties of Xinjiang, Gansu, Sichuan, Inner Mongolia, Shanxi, and Shaanxi provinces (autonomous regions)...
October 16, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
Jakub Misek, Igor Belyaev, Viera Jakusova, Ingrid Tonhajzerova, Jan Barabas, Jan Jakus
This study examines the possible effect of radiofrequency (RF) electromagnetic fields (EMF) on the autonomic nervous system (ANS). The effect of RF EMF on ANS activity was studied by measuring heart rate variability (HRV) during ortho-clinostatic test (i.e., transition from lying to standing and back) in 46 healthy grammar school students. A 1788 MHz pulsed wave with intensity of 54 ± 1.6 V/m was applied intermittently for 18 min in each trial. Maximum specific absorption rate (SAR10 ) value was determined to 0...
February 22, 2018: Bioelectromagnetics
Joshua Spurrier, Arvind Kumar Shukla, Kristina McLinden, Kory Johnson, Edward Giniger
Aging is the greatest risk factor for neurodegeneration, but the connection between the two processes remains opaque. This is in part for want of a rigorous way to define physiological age, as opposed to chronological age. Here we develop a comprehensive metric for physiological age in Drosophila, based on genome-wide expression profiling. We applied this metric to a model of adult-onset neurodegeneration, increased or decreased expression of the activating subunit of the Cdk5 protein kinase, encoded by the gene Cdk5α , the ortholog of mammalian p35...
February 21, 2018: Disease Models & Mechanisms
S Y Ha, K M Park, J Park, S E Kim, B I Lee, K J Shin
OBJECTIVE: Neurological progression is a major problem in managing the patients with acute lacunar infarction. The purpose of this was to investigate whether autonomic dysfunction is associated with neurological progression in patients with acute lacunar infarction. MATERIALS AND METHODS: The study comprised 60 patients with acute lacunar infarction. All enrolled subjects underwent autonomic function tests including the 30° head-up tilt test, Valsalva test, heart rate response to deep breathing, and sympathetic skin response...
February 21, 2018: Acta Neurologica Scandinavica
Myoung-Gwi Ryou, Robert T Mallet
Ischemia-reperfusion syndromes of the heart and brain are the leading cause of death and long-term disability worldwide. Development of effective treatments for myocardial infarction, stroke, cardiac arrest and their sequelae requires preclinical models that replicate specific features of ischemia-reperfusion. The complexities of intact animals, including the integrated function of organ systems, autonomic innervation and endocrine factors, often preclude detailed study of specific components of ischemia-reperfusion injury cascades...
2018: Methods in Molecular Biology
Bruno Bonaz, Thomas Bazin, Sonia Pellissier
The microbiota, the gut, and the brain communicate through the microbiota-gut-brain axis in a bidirectional way that involves the autonomic nervous system. The vagus nerve (VN), the principal component of the parasympathetic nervous system, is a mixed nerve composed of 80% afferent and 20% efferent fibers. The VN, because of its role in interoceptive awareness, is able to sense the microbiota metabolites through its afferents, to transfer this gut information to the central nervous system where it is integrated in the central autonomic network, and then to generate an adapted or inappropriate response...
2018: Frontiers in Neuroscience
Jennifer J Brout, Miren Edelstein, Mercede Erfanian, Michael Mannino, Lucy J Miller, Romke Rouw, Sukhbinder Kumar, M Zachary Rosenthal
Misophonia is a neurobehavioral syndrome phenotypically characterized by heightened autonomic nervous system arousal and negative emotional reactivity (e. g., irritation, anger, anxiety) in response to a decreased tolerance for specific sounds. The aims of this review are to (a) characterize the current state of the field of research on misophonia, (b) highlight what can be inferred from the small research literature to inform treatment of individuals with misophonia, and (c) outline an agenda for research on this topic...
2018: Frontiers in Neuroscience
Takayuki Yamada, Okiko Habara, Hitomi Kubo, Takashi Nishimura
Adapting to changes in food availability is a central challenge for survival. Glucose is an important resource for energy production, and therefore, many organisms synthesize and retain sugar storage molecules. In insects, glucose is stored in two different forms: the disaccharide trehalose and the branched polymer glycogen. Glycogen is synthesized and stored in several tissues, including in muscle and the fat body. Despite the important role of the fat body as a center for energy metabolism, the importance of its glycogen content remains unclear...
February 21, 2018: Development
Sandra Lamouroux-López, Merling López, Héctor Flores
Pseudocurimata lineopunctata represents an important nutritional source for local human communities in Colombia and Ecuador. Although the yearly catch of this fish is low (590 kg/year), there are no restrictions on minimum size, and this species is categorized as vulnerable with moderate extinction risk by the Regional Autonomous Corporation of the Cauca Valley (Colombia). To support conservation programs, biological data of the target species are required. Therefore, the aims of this study were to describe the sex ratio, distribution, size to weight ratio, macroscopic stages of reproductive maturity, fecundity, and size at first sexual maturity for P...
March 2017: Revista de Biología Tropical
Josária Ferraz Amaral, Diana de Medeiros Andrade Borsato, Isabelle Magalhães Guedes Freitas, Edgar Toschi-Dias, Daniel Godoy Martinez, Mateus Camaroti Laterza
BACKGROUND: Individuals with a family history of systemic arterial hypertension (FHSAH) and / or prehypertension have a higher risk of developing this pathology. OBJECTIVE: To evaluate the autonomic and vascular functions of prehypertensive patients with FHSAH. METHODS: Twenty-five young volunteers with FHSAH, 14 normotensive and 11 prehypertensive subjects were submitted to vascular function evaluation by forearm vascular conductance(VC) during resting and reactive hyperemia (Hokanson®) and cardiac and peripheral autonomic modulation, quantified, respectively, by spectral analysis of heart rate (ECG) and systolic blood pressure (SBP) (FinometerPRO®)...
February 19, 2018: Arquivos Brasileiros de Cardiologia
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