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https://www.readbyqxmd.com/read/28533285/phosphodiesterase-inhibitors-such-as-viagra-do-not-increase-melanoma-risk-review-finds
#1
Susan Mayor
No abstract text is available yet for this article.
May 21, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28533270/classical-activation-of-macrophages-and-vardenafil
#2
Richmond Muimo
Inhibitors of phosphodiesterase 5 (PDE5) - sildenafil citrate (Viagra; Pfizer) and vardenafil hydrochloride (Levitra; Bayer/GlaxoSmithKline) - approved for the treatment of erectile dysfunction and pulmonary arterial hypertension also rescue the loss of cystic fibrosis (CF) chloride channel function and the mislocalization of F508del-CFTR in affected tissues in CF. Can PDE5 inhibitors provide a therapeutic strategy which combines ability to correct the basic ion transport defect and to control de-regulated lung inflammation in CF?...
June 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28442892/bioequivalence-study-of-a-new-sildenafil-100-mg-orodispersible-film-compared-to-the-conventional-film-coated-100-mg-tablet-administered-to-healthy-male-volunteers
#3
Milko Radicioni, Chiara Castiglioni, Andrea Giori, Irma Cupone, Valeria Frangione, Stefano Rovati
A new orodispersible film formulation of the phosphodiesterase type 5 inhibitor, sildenafil, has been developed to examine the advantages of an orally disintegrating film formulation and provide an alternative to the current marketed products for the treatment of erectile dysfunction. The pharmacokinetics of the sildenafil 100 mg orodispersible film (IBSA) was compared to that of the conventional marketed 100 mg film-coated tablet (Viagra(®)) after single-dose administration to 53 healthy male volunteers (aged 18-51 years) in a randomized, open, two-way crossover bioequivalence study...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28434386/flibanserin-the-female-viagra
#4
Desiree Shapiro, Deanna Stevens, Stephen M Stahl
This article provides a clinically relevant review of the first medication approved by the US Food and Drug Administration for hypoactive sexual desire disorder (HSDD) in premenopausal women. In this short piece, the human sexual response cycle and its relevance to HSDD will be described as well as the pharmacological mechanism of action of flibanserin. Finally, efficacy and safety data of this new medication will be summarised.
April 24, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28410750/assessing-the-impact-of-diclofenac-ibuprofen-and-sildenafil-citrate-viagra-%C3%A2-on-the-fertilisation-biology-of-broadcast-spawning-marine-invertebrates
#5
Norlaila Binti Mohd Zanuri, Matthew G Bentley, Gary S Caldwell
Exposure to synthetic chemicals is a key environmental challenge faced by aquatic organisms. The time and dose effects of the pharmaceuticals diclofenac, ibuprofen, and sildenafil citrate on sperm motility and successful fertilisation are studied using the echinoderms, Asterias rubens and Psammechinus miliaris, and the polychaete worm Arenicola marina, all important components of the marine benthos. Motility was reduced for all species when exposed to diclofenac concentrations ≥0.1 μg/L. Exposure to ≥1...
April 8, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/28390608/using-sildenafil-viagra-to-treat-congenital-lymphatic-malformations-of-the-head-and-neck-our-experience
#6
John Rocke, Gavin Quail, Graeme Copley
No abstract text is available yet for this article.
May 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28379598/sildenafil-associated-hepatoxicity-a-review-of-the-literature
#7
S Graziano, A Montana, S Zaami, M C Rotolo, A Minutillo, F P Busardò, E Marinelli
Sildenafil citrate (Viagra®) is a vasoactive agent available worldwide since 1998 for the treatment of male erectile dysfunction. It is a selective phosphodiesterase type 5-enzyme inhibitor able to potentiate the downstream effects of nitric oxide on smooth muscle relaxation and vasodilation through its effects on the cyclic guanosine monophosphate (c-GMP) pathway in the erectile tissue of the penis. When sildenafil is orally administered, it is rapidly absorbed with a maximum plasma concentration achieved within 1 h and has a terminal half-life of between 3 to 6 h...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28271985/for-ed-the-doctor-is-in-but-the-men-are-staying-away
#8
Joseph Burns
Men's health care changed dramatically after the FDA approved Pfizer's blue, diamond-shaped Viagra. Suddenly men were interested in seeing their doctors if for only one reason. Now, with restrictions on what some call a lifestyle drug, other health problems go uncharted.
February 2017: Managed Care
https://www.readbyqxmd.com/read/28237322/effect-of-chronic-administration-of-sildenafil-citrate-viagra-on-the-histology-of-the-retina-and-optic-nerve-of-adult-male-rat
#9
Sohair A Eltony, Sally Y Abdelhameed
BACKGROUND: Abnormal vision has been reported by 3% of patients treated with sildenafil citrate (Viagra). Although many men use Viagra for an extended period for treatment of erectile dysfunction, the implications of the long term-daily use of it on the retina and optic nerve are unclear. AIM OF THE WORK: To investigate the effect of chronic daily use of sildenafil citrate in a dose equivalent to men preferred therapeutic dose on the histology of the retina and optic nerve of adult male rat...
April 2017: Tissue & Cell
https://www.readbyqxmd.com/read/28040654/verification-of-the-authenticity-of-drugs-by-means-of-nmr-relaxometry-viagra-%C3%A2-as-an-example
#10
S Wilczyńki, M Petelenz, M Florek-Wojciechowska, S Kulesza, Sz Brym, B Błońska-Fajfrowska, D Kruk
(1)H spin-lattice Nuclear Magnetic Resonance (NMR) relaxometry, vibrational spectroscopy and Atomic Force Microscopy (AFM) have been applied to differentiate between original and counterfeit Viagra(®). The relaxation studies have been performed in a frequency range covering four orders of magnitude, from 4kHz to 40MHz. It has been shown that for the counterfeit product the relaxation is bi-exponential in the whole frequency range, while for the original Viagra(®) the relaxation process is always single exponential...
February 20, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28025967/a-single-dose-randomized-open-label-cross-over-bioequivalence-study-of-sildenafil-citrate-tablets-in-healthy-chinese-volunteers%C3%A2
#11
Dai Li, Yu-Lu Wang, Su-Mei Xu, Dan Li, Xiao-Min Li, Jing Pan, Ping-Sheng Xu
OBJECTIVE: The present study was designed to evaluate the bioequivalence of a newly developed sildenafil citrate tablet 50 mg (Jinge<sup>®</sup>, Test) and a marketed counterpart (Viagra<sup>®</sup>, 100 mg, Reference) in healthy adult male Chinese volunteers. METHODS: This single-dose, randomized, open-label, four-period, and two-treatment self-crossover study included two parts: fasting and postprandial studies. In each part of the study, the subjects were randomly assigned to receive test or reference products (100 mg sildenafil) in a 1 : 1 ratio, and then received the alternative products, following a 1-week washout period...
February 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27860446/a-genetic-algorithm-based-framework-for-wavelength-selection-on-sample-categorization
#12
Michel J Anzanello, Gabrielli Yamashita, Marcelo Marcelo, Flavio F Fogliatto, Rafael S Ortiz, Kristiane Mariotti, Marco F Ferrão
In forensic and pharmaceutical scenarios, the application of chemometrics and optimization techniques have unveiled common and peculiar features of seized medicine and drug samples, helping investigative forces towards tracking illegal operations. This paper proposes a novel framework aimed at identifying relevant subsets of attenuated total reflectance Fourier transform infrared (ATR-FTIR) wavelengths for classifying samples into two classes, e.g. authentic or forged categories in case of medicines, or salt or base form in cocaine analysis...
November 18, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27800121/erectile-dysfunction-drugs-changed-the-protein-expressions-and-activities-of-drug-metabolising-enzymes-in-the-liver-of-male-rats
#13
Salah A Sheweita, Mona Wally, Mostafa Hassan
Erectile dysfunction (ED) is a major health problem and is mainly associated with the persistent inability of men to maintain sufficient erection for satisfactory sexual performance. Millions of men are using sildenafil, vardenafil, and/or tadalafil for ED treatment. Cytochrome P450s (CYPs) play a central role in the metabolism of a wide range of xenobiotics as well as endogenous compounds. Susceptibility of individuals to the adverse effects of different drugs is mainly dependent on the expression of CYPs proteins...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27663307/-efficacy-and-safety-of-flibanserin-new-female-viagra-%C3%A2-literature-review
#14
C Terrier, J-E Terrier
INTRODUCTION: In August 2015, the US Food and Drug Administration (FDA) has approved Addyi(®) (flibanserin) for treatment of acquired, generalized hypoactive sexual desire disorder (HSDD) in pre-menopausal women. We carried out a systematic review and meta-analysis to assess the efficacy and safety of the drug in women with HSDD. PATIENTS AND METHODS: A systematic literature review from the PubMed database search was carried out until April 2016 using the following keywords: "HSDD", "flibanserin", "sexual desire" and "ransomised controlled trial"...
September 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27650039/propping-up-pharma-s-natural-neoliberal-phallic-man-pharmaceutical-representations-of-the-ideal-sexuopharmaceutical-user
#15
Maria Gurevich, Usra Leedham, Amy Brown-Bowers, Nicole Cormier, Zara Mercer
Contemporary social theorists emphasise the cultural quest for authenticity under conditions of increasing artificiality. Within this context, the body is commonly treated as an 'unfinished' surface requiring ongoing transformation to fulfil identity obligations. In this paper, we examine one such identity authentication project in the form of marketing of men's sexuopharmaceuticals. We use online pharmaceutical advertising for four approved sexuopharmaceuticals (Viagra, Cialis, STAXYN and Stendra) to describe the ideal neoliberal consumer...
April 2017: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/27591580/the-use-of-hyperspectral-imaging-in-the-vnir-400-1000nm-and-swir-range-1000-2500nm-for-detecting-counterfeit-drugs-with-identical-api-composition
#16
Sławomir Wilczyński, Robert Koprowski, Mathieu Marmion, Piotr Duda, Barbara Błońska-Fajfrowska
The risk of death from taking counterfeit drugs is now greater than the probability of dying from malaria and AIDS combined (at least half a million deaths each year). At the same time, counterfeit medicines are falsified more and more "skillfully". According to WHO about 10% of counterfeit drugs are copies of original products. The methods of hyperspectral imaging and image analysis and processing were used to detect counterfeit drugs. Original Viagra® (Pfizer) and counterfeit tablets were compared. Hyperspectral imaging was used to acquire hyperspectral data cubes from both original and counterfeit tablets in the spectral range of 400-2500nm...
November 1, 2016: Talanta
https://www.readbyqxmd.com/read/27494460/maturing-masculinites-aging-chronic-illness-and-viagra-in-mexico
#17
Emily E Vasquez
No abstract text is available yet for this article.
August 5, 2016: Global Public Health
https://www.readbyqxmd.com/read/27471409/extent-of-dispensing-prescription-only-medications-without-a-prescription-in-community-drug-retail-outlets-in-addis-ababa-ethiopia-a-simulated-patient-study
#18
Daniel Asfaw Erku, Abebe Basazn Mekuria, Abdrrahman Shemsu Surur, Begashaw Melaku Gebresillassie
PURPOSE: This study was aimed at assessing the extent of dispensing prescription-only medications without a prescription in community drug retail outlets (CDROs) of Addis Ababa, Ethiopia. METHODS: A descriptive cross-sectional observational study design was used to sample 31 pharmacies, 25 drug stores, and two rural drug vendors from August 11, 2015, to October 21, 2015, through a simple random sampling method. A simulated-patient method of visit was implemented to collect data...
2016: Drug, Healthcare and Patient Safety
https://www.readbyqxmd.com/read/27466020/sildenafil-viagra-%C3%A2-prevents-and-restores-lps-induced-inflammation-in-astrocytes
#19
Ana Karolina de Santana Nunes, Catarina Rapôso, Ulrika Björklund, Maria Alice da Cruz-Höfling, Christina Alves Peixoto, Elisabeth Hansson
Astrocytes are effectively involved in the pathophysiological processes in the central nervous system (CNS) and may contribute to or protect against development of inflammatory and degenerative diseases. Sildenafil is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor, which induces cyclic GMP accumulation. However, the mechanisms of actions on glial cells are not clear. The aim of the present work is to evaluate the role of sildenafil in lipopolysaccharide (LPS)-stimulated astrocytes. The cytoskeleton integrity and Ca(2+) waves were assessed as indicators of inflammatory state...
September 6, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27152308/flibanserin-for-treating-hypoactive-sexual-desire-disorder
#20
REVIEW
Jae Hong Sang, Tae-Hee Kim, Soo Ah Kim
There have been several products developed for male sexual dysfunction. However, developing agents for female sexual dysfunction is lagging behind for various reasons. Sildenafil citrate (Viagra) and Tadalafil (Cialis), which have been prescribed for male sexual function disorders, are known to act on vessels.[1] On the other hand, flibanserin is thought to act on brain. Flibanserin has been approved by U. S. Food and Drug Administration (FDA) for treatment of hypoactive sexual desire disorder (HSDD) of premenopausal women in 2015, and is expected to be released in South Korea soon...
April 2016: Journal of Menopausal Medicine
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