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https://www.readbyqxmd.com/read/27860446/a-genetic-algorithm-based-framework-for-wavelength-selection-on-sample-categorization
#1
Michel J Anzanello, Gabrielli Yamashita, Marcelo Marcelo, Flavio F Fogliatto, Rafael S Ortiz, Kristiane Mariotti, Marco F Ferrão
In forensic and pharmaceutical scenarios, the application of chemometrics and optimization techniques have unveiled common and peculiar features of seized medicine and drug samples, helping investigative forces towards tracking illegal operations. This paper proposes a novel framework aimed at identifying relevant subsets of attenuated total reflectance Fourier transform infrared (ATR-FTIR) wavelengths for classifying samples into two classes, e.g. authentic or forged categories in case of medicines, or salt or base form in cocaine analysis...
November 18, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/27800121/erectile-dysfunction-drugs-changed-the-protein-expressions-and-activities-of-drug-metabolising-enzymes-in-the-liver-of-male-rats
#2
Salah A Sheweita, Mona Wally, Mostafa Hassan
Erectile dysfunction (ED) is a major health problem and is mainly associated with the persistent inability of men to maintain sufficient erection for satisfactory sexual performance. Millions of men are using sildenafil, vardenafil, and/or tadalafil for ED treatment. Cytochrome P450s (CYPs) play a central role in the metabolism of a wide range of xenobiotics as well as endogenous compounds. Susceptibility of individuals to the adverse effects of different drugs is mainly dependent on the expression of CYPs proteins...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27663307/-efficacy-and-safety-of-flibanserin-new-female-viagra-%C3%A2-literature-review
#3
C Terrier, J-E Terrier
INTRODUCTION: In August 2015, the US Food and Drug Administration (FDA) has approved Addyi(®) (flibanserin) for treatment of acquired, generalized hypoactive sexual desire disorder (HSDD) in pre-menopausal women. We carried out a systematic review and meta-analysis to assess the efficacy and safety of the drug in women with HSDD. PATIENTS AND METHODS: A systematic literature review from the PubMed database search was carried out until April 2016 using the following keywords: "HSDD", "flibanserin", "sexual desire" and "ransomised controlled trial"...
September 20, 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27650039/propping-up-pharma-s-natural-neoliberal-phallic-man-pharmaceutical-representations-of-the-ideal-sexuopharmaceutical-user
#4
Maria Gurevich, Usra Leedham, Amy Brown-Bowers, Nicole Cormier, Zara Mercer
Contemporary social theorists emphasise the cultural quest for authenticity under conditions of increasing artificiality. Within this context, the body is commonly treated as an 'unfinished' surface requiring ongoing transformation to fulfil identity obligations. In this paper, we examine one such identity authentication project in the form of marketing of men's sexuopharmaceuticals. We use online pharmaceutical advertising for four approved sexuopharmaceuticals (Viagra, Cialis, STAXYN and Stendra) to describe the ideal neoliberal consumer...
September 21, 2016: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/27591580/the-use-of-hyperspectral-imaging-in-the-vnir-400-1000nm-and-swir-range-1000-2500nm-for-detecting-counterfeit-drugs-with-identical-api-composition
#5
Sławomir Wilczyński, Robert Koprowski, Mathieu Marmion, Piotr Duda, Barbara Błońska-Fajfrowska
The risk of death from taking counterfeit drugs is now greater than the probability of dying from malaria and AIDS combined (at least half a million deaths each year). At the same time, counterfeit medicines are falsified more and more "skillfully". According to WHO about 10% of counterfeit drugs are copies of original products. The methods of hyperspectral imaging and image analysis and processing were used to detect counterfeit drugs. Original Viagra® (Pfizer) and counterfeit tablets were compared. Hyperspectral imaging was used to acquire hyperspectral data cubes from both original and counterfeit tablets in the spectral range of 400-2500nm...
November 1, 2016: Talanta
https://www.readbyqxmd.com/read/27494460/maturing-masculinites-aging-chronic-illness-and-viagra-in-mexico
#6
Emily E Vasquez
No abstract text is available yet for this article.
August 5, 2016: Global Public Health
https://www.readbyqxmd.com/read/27471409/extent-of-dispensing-prescription-only-medications-without-a-prescription-in-community-drug-retail-outlets-in-addis-ababa-ethiopia-a-simulated-patient-study
#7
Daniel Asfaw Erku, Abebe Basazn Mekuria, Abdrrahman Shemsu Surur, Begashaw Melaku Gebresillassie
PURPOSE: This study was aimed at assessing the extent of dispensing prescription-only medications without a prescription in community drug retail outlets (CDROs) of Addis Ababa, Ethiopia. METHODS: A descriptive cross-sectional observational study design was used to sample 31 pharmacies, 25 drug stores, and two rural drug vendors from August 11, 2015, to October 21, 2015, through a simple random sampling method. A simulated-patient method of visit was implemented to collect data...
2016: Drug, Healthcare and Patient Safety
https://www.readbyqxmd.com/read/27466020/sildenafil-viagra-%C3%A2-prevents-and-restores-lps-induced-inflammation-in-astrocytes
#8
Ana Karolina de Santana Nunes, Catarina Rapôso, Ulrika Björklund, Maria Alice da Cruz-Höfling, Christina Alves Peixoto, Elisabeth Hansson
Astrocytes are effectively involved in the pathophysiological processes in the central nervous system (CNS) and may contribute to or protect against development of inflammatory and degenerative diseases. Sildenafil is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor, which induces cyclic GMP accumulation. However, the mechanisms of actions on glial cells are not clear. The aim of the present work is to evaluate the role of sildenafil in lipopolysaccharide (LPS)-stimulated astrocytes. The cytoskeleton integrity and Ca(2+) waves were assessed as indicators of inflammatory state...
September 6, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27152308/flibanserin-for-treating-hypoactive-sexual-desire-disorder
#9
REVIEW
Jae Hong Sang, Tae-Hee Kim, Soo Ah Kim
There have been several products developed for male sexual dysfunction. However, developing agents for female sexual dysfunction is lagging behind for various reasons. Sildenafil citrate (Viagra) and Tadalafil (Cialis), which have been prescribed for male sexual function disorders, are known to act on vessels.[1] On the other hand, flibanserin is thought to act on brain. Flibanserin has been approved by U. S. Food and Drug Administration (FDA) for treatment of hypoactive sexual desire disorder (HSDD) of premenopausal women in 2015, and is expected to be released in South Korea soon...
April 2016: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/27136945/plasmodium-falciparum-stevor-phosphorylation-regulates-host-erythrocyte-deformability-enabling-malaria-parasite-transmission
#10
Bernina Naissant, Florian Dupuy, Yoann Duffier, Audrey Lorthiois, Julien Duez, Judith Scholz, Pierre Buffet, Anais Merckx, Anna Bachmann, Catherine Lavazec
Deformability of Plasmodium falciparum gametocyte-infected erythrocytes (GIEs) allows them to persist for several days in blood circulation and to ensure transmission to mosquitoes. Here, we investigate the mechanism by which the parasite proteins STEVOR (SubTElomeric Variable Open Reading frame) exert changes on GIE deformability. Using the microsphiltration method, immunoprecipitation, and mass spectrometry, we produce evidence that GIE stiffness is dependent on the cytoplasmic domain of STEVOR that interacts with ankyrin complex at the erythrocyte skeleton...
June 16, 2016: Blood
https://www.readbyqxmd.com/read/26978649/effects-of-sildenafil-citrate-and-heparin-treatments-on-placental-cell-morphology-in-a-murine-model-of-pregnancy-loss
#11
Rayana Leal Luna, Anne Gabrielle Vasconcelos, Ana Karolina Santana Nunes, Wilma Helena de Oliveira, Karla Patricia de Sousa Barbosa, Christina Alves Peixoto
Lipopolysaccharide (LPS) injections during pregnancy are well established as models for pregnancy complications, including fetal growth restriction (FGR), thrombophilia, preterm labor and abortion. Indeed, inflammation, as induced by LPS injection has been described as a pivotal factor in cases of miscarriage related to placental tissue damage. The phosphodiesterase-5 inhibitor sildenafil (Viagra®) is currently used to treat FGR cases in women, while low-molecular weight heparin (Fragmin®) is a standard treatment for recurrent miscarriage (RM)...
2016: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/26977587/directional-reflectance-analysis-for-identifying-counterfeit-drugs-preliminary-study
#12
Sławomir Wilczyński, Robert Koprowski, Barbara Błońska-Fajfrowska
The WHO estimates that up to 10% of drugs on the market may be counterfeit. In order to prevent intensification of the phenomenon of drug counterfeiting, the methods for distinguishing genuine medicines from fake ones need to be developed. The aim of this study was to try to develop simple, reproducible and inexpensive method for distinguishing between original and counterfeit medicines based on the measurement of directional reflectance. The directional reflectance of 6 original Viagra(®) tablets (Pfizer) and 24 (4 different batches) counterfeit tablets (imitating Viagra(®)) was examined in six spectral bands: from 0...
May 30, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/26938750/bioequivalence-of-2-formulations-of-sildenafil-oral-soluble-film-100-mg-and-sildenafil-citrate-viagra-100-mg-oral-tablets-in-healthy-male-volunteers
#13
Eric Dadey
Sildenafil citrate tablets (VIAGRA; Pfizer Inc) have been used since 1998 as an oral therapy for the treatment of erectile dysfunction. However, in some cases, patients may have difficulty in swallowing tablets, and the need to use water to aid in the oral administration of the tablets has the potential to interrupt the sexual encounter, reduce spontaneity, and therefore decrease the quality of the experience. Two oral soluble film (OSF) formulations of sildenafil were developed using MonoSol Rx's proprietary PharmFilm technology...
July 4, 2015: American Journal of Therapeutics
https://www.readbyqxmd.com/read/26778321/assessment-of-penile-erection-methods-in-rhesus-macaques-to-model-pharmacokinetics-of-antiretroviral-drugs-and-penile-infection-with-simian-immunodeficiency-virus
#14
James Hayes, Nathaniel Powell, George Lathrop, Walid Heneine, Charles W Dobard
BACKGROUND: An established macaque model to assess HIV interventions against penile transmission is currently not available. Physiological changes during penile erections may affect susceptibility to infection and drug pharmacokinetics (PK). Here, we identify methods to establish erections in macaques to evaluate penile transmission, PK, and efficacy under physiologic conditions. METHODS: Penile rigidity and length were evaluated in eight rhesus macaques following rectal electrostimulation (RES), vibratory stimulation (VS), or pharmacological treatment with Sildenafil Citrate (Viagra) or Alprostadil...
February 2016: Journal of Medical Primatology
https://www.readbyqxmd.com/read/26730545/the-monte-carlo-validation-framework-for-the-discriminant-partial-least-squares-model-extended-with-variable-selection-methods-applied-to-authenticity-studies-of-viagra%C3%A2-based-on-chromatographic-impurity-profiles
#15
B Krakowska, D Custers, E Deconinck, M Daszykowski
The aim of this work was to develop a general framework for the validation of discriminant models based on the Monte Carlo approach that is used in the context of authenticity studies based on chromatographic impurity profiles. The performance of the validation approach was applied to evaluate the usefulness of the diagnostic logic rule obtained from the partial least squares discriminant model (PLS-DA) that was built to discriminate authentic Viagra® samples from counterfeits (a two-class problem). The major advantage of the proposed validation framework stems from the possibility of obtaining distributions for different figures of merit that describe the PLS-DA model such as, e...
February 7, 2016: Analyst
https://www.readbyqxmd.com/read/26716643/sildenafil-viagra-sensitizes-prostate-cancer-cells-to-doxorubicin-mediated-apoptosis-through-cd95
#16
Anindita Das, David Durrant, Clint Mitchell, Paul Dent, Surinder K Batra, Rakesh C Kukreja
We previously reported that Sildenafil enhances apoptosis and antitumor efficacy of doxorubicin (DOX) while attenuating its cardiotoxic effect in prostate cancer. In the present study, we investigated the mechanism by which sildenafil sensitizes DOX in killing of prostate cancer (PCa) cells, DU145. The death receptor Fas (APO-1 or CD95) induces apoptosis in many carcinoma cells, which is negatively regulated by anti-apoptotic molecules such as FLIP (Fas-associated death domain (FADD) interleukin-1-converting enzyme (FLICE)-like inhibitory protein)...
January 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/26641206/pharmacokinetic-investigation-of-sildenafil-using-positron-emission-tomography-and-determination-of-its-effect-on-cerebrospinal-fluid-cgmp-levels
#17
Vanessa Gómez-Vallejo, Ana Ugarte, Carolina García-Barroso, Mar Cuadrado-Tejedor, Boguslaw Szczupak, Iria G Dopeso-Reyes, José L Lanciego, Ana García-Osta, Jordi Llop, Julen Oyarzabal, Rafael Franco
Sildenafil (Viagra) is a selective inhibitor of phosphodiesterase type 5 (PDE5), which degrades cyclic guanosine monophosphate to the linear nucleotide. Sildenafil is acutely used in erectile dysfunction and chronically in pulmonary hypertension. Evidence in the last decade shows that sildenafil may have potential as a therapeutic option for Alzheimer's disease or other neurodegenerative disorders. The purpose of this work was to explore whether sildenafil crosses the blood-brain barrier. Pharmacokinetic properties of sildenafil in rodents were investigated using (11) C-radiolabeling followed by in vivo positron emission tomography (PET) and ex vivo tissue dissection and gamma counting...
January 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/26637485/study-on-health-hazards-through-medicines-purchased-on-the-internet-a-cross-sectional-investigation-of-the-quality-of-anti-obesity-medicines-containing-crude-drugs-as-active-ingredients
#18
Naoko Yoshida, Midori Numano, Yoko Nagasaka, Kaori Ueda, Hirohito Tsuboi, Tsuyoshi Tanimoto, Kazuko Kimura
BACKGROUND: Weight-loss medicines, including crude drugs and herbal supplements disguised as diet-aid products, are readily obtainable and distributed widely, especially in Southeast Asia. Even if such products are unapproved or prescription-only medicines, consumers can purchase them through an agency or directly on the Internet. We evaluated the quality and safety of herbal products purchased on the Internet to reveal their influence on public health. METHODS: Diet-aid products containing Bukuryo (Poria sclerotium), Bakumondo (Ophiopogonis tuber), or Daio (rhubarb rhizome) were purchased through websites that did not provide physical addresses or which advertised misleading medicines (e...
2015: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/26569234/sildenafil-protects-against-myocardial-ischemia-reperfusion-injury-following-cardiac-arrest-in-a-porcine-model-possible-role-of-the-renin-angiotensin-system
#19
Guoxing Wang, Qian Zhang, Wei Yuan, Junyuan Wu, Chunsheng Li
Sildenafil, a phosphodiesterase-5 inhibitor sold as Viagra, is a cardioprotector against myocardial ischemia/reperfusion (I/R) injury. Our study explored whether sildenafil protects against I/R-induced damage in a porcine cardiac arrest and resuscitation (CAR) model via modulating the renin-angiotensin system. Male pigs were randomly divided to three groups: Sham group, Saline group, and sildenafil (0.5 mg/kg) group. Thirty min after drug infusion, ventricular fibrillation (8 min) and cardiopulmonary resuscitation (up to 30 min) was conducted in these animals...
2015: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/26555512/a-matter-of-sexual-confidence-young-men-s-non-prescription-use-of-viagra-in-addis-ababa-ethiopia
#20
Rosalijn Both
This paper examines the non-prescription use of the sexual enhancement drug Viagra by young men in Addis Ababa. Data was collected through repeated in-depth interviews with 14 Viagra users - heterosexual men between the ages of 21 and 35 - and focus-group discussions with 21 male and 22 female university students. Study participants turned to Viagra to impress lovers, as a 'support mechanism' when feeling weak or tired, to counteract the effects of chewing the stimulant plant khat and to satisfy what they perceived as a psychological 'addiction'...
2016: Culture, Health & Sexuality
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