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https://www.readbyqxmd.com/read/29346709/rating-the-quality-of-a-body-of-evidence-on-the-effectiveness-of-health-and-social-interventions-a-systematic-review-and-mapping-of-evidence-domains
#1
Ani Movsisyan, Jane Dennis, Eva Rehfuess, Sean Grant, Paul Montgomery
INTRODUCTION: Rating the quality of a body of evidence is an increasingly common component of research syntheses on intervention effectiveness. This study sought to identify and examine existing systems for rating the quality of a body of evidence on the effectiveness of health and social interventions. METHODS: We used a multi-component search strategy to search for full-length reports of systems for rating the quality of a body of evidence on the effectiveness of health and social interventions published in English from 1995 onward...
January 18, 2018: Research Synthesis Methods
https://www.readbyqxmd.com/read/29346495/long-term-temporal-changes-in-structure-and-function-of-rat-visual-system-after-blast-exposure
#2
Daniel F Shedd, Nikolaus A Benko, Justin Jones, Brian E Zaugg, Robert L Peiffer, Brittany Coats
Purpose: We identify long-term ocular sequelae subsequent to experimental blast exposure. Methods: Male Long-Evans rats were exposed to 230 kPa side-on primary blast overpressure using a compressed air driven shock tube. Visual system function and structure were assessed for 8 weeks after exposure using optokinetic nystagmus and optical coherence tomography. Vitreous protein expression and histology (TUNEL, H&E) were performed at 1 day and 1, 4, and 8 weeks. IOP was recorded bilaterally during blast in a subset of animals...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29346244/comparing-fundus-fluorescein-angiography-and-swept-source-optical-coherence-tomography-angiography-in-the-evaluation-of-diabetic-macular-perfusion
#3
Alberto La Mantia, Rengin A Kurt, Samantha Mejor, Catherine A Egan, Adnan Tufail, Pearse A Keane, Dawn A Sim
PURPOSE: To compare fundus fluorescein angiography (FFA) and swept-source optical coherence tomography angiography (SS-OCTA) in the evaluation of macular perfusion in diabetic patients. METHODS: Forty-one eyes (21 diabetic patients) seen at Moorfields Eye Hospital (London) over a 1-month interval underwent color fundus photography, FFA, and SS-OCTA imaging of the capillary superficial plexus using 2 different protocols: 3 × 3 mm and 4.5 × 4.5 mm. Quantitative assessment (foveal avascular zone diameters and area), qualitative analysis (macroscopic and microscopic levels) and Early Treatment Diabetic Retinopathy Study diabetic macular ischemia grading were performed...
January 16, 2018: Retina
https://www.readbyqxmd.com/read/29346242/prevalence-and-clinical-characteristics-of-pachydrusen-in-polypoidal-choroidal-vasculopathy-multimodal-image-study
#4
Junwon Lee, Suk Ho Byeon
PURPOSE: To investigate the prevalence of a newly defined drusen type, pachydrusen, soft drusen, and subretinal drusenoid deposits in eyes with polypoidal choroidal vasculopathy and fellow eyes and the relationship between each drusen type and the choroidal thickness, vascular morphology, and hyperpermeability. METHODS: The 169 eyes of 90 patients with polypoidal choroidal vasculopathy were retrospectively reviewed. The prevalence of each drusen type was evaluated using color fundus photography and optical coherence tomography...
January 16, 2018: Retina
https://www.readbyqxmd.com/read/29346241/chronic-central-serous-chorioretinopathy-early-and-late-morphological-and-functional-changes-after-verteporfin-photodynamic-therapy
#5
Pierluigi Iacono, Massimiliano Tedeschi, Barbara Boccassini, Adele Chiaravalloti, Monica Varano, Mariacristina Parravano
PURPOSE: To describe early and late morphological and functional changes in subjects receiving photodynamic therapy (PDT) for chronic central serous chorioretinopathy. METHODS: Patients with chronic central serous chorioretinopathy were prospectively enrolled and received standard PDT. At the baseline examination, each subject underwent complete ophthalmological examination, including best-corrected visual acuity (BCVA) assessment, fluorescein angiography and indocyanine green angiography, spectral domain optical coherence tomography, and microperimetry...
January 16, 2018: Retina
https://www.readbyqxmd.com/read/29346240/response-of-inflammatory-cystoid-macular-edema-to-treatment-using-oral-acetazolamide
#6
Kathryn L Pepple, Macklin H Nguyen, Kaivon Pakzad-Vaezi, Kathleen Williamson, Naomi Odell, Cecilia Lee, Thellea K Leveque, Russell N Van Gelder
PURPOSE: To determine the treatment effect of oral acetazolamide on refractory inflammatory macular edema. METHODS: A retrospective review of identified patients with uveitic or pseudophakic macular edema treated using acetazolamide between 2007 and 2014. Visual acuity and central macular subfield thickness was determined at baseline and at first follow-up. Baseline optical coherence tomography features were analyzed as predictors of acetazolamide response. RESULTS: Sixteen patients (19 eyes) of 61 screened met all criteria...
January 16, 2018: Retina
https://www.readbyqxmd.com/read/29346239/factors-associated-with-development-of-dissociated-optic-nerve-fiber-layer-appearance-in-the-pioneer-intraoperative-optical-coherence-tomography-study
#7
Anne P Runkle, Sunil K Srivastava, Alex Yuan, Peter K Kaiser, Rishi P Singh, Jamie L Reese, Justis P Ehlers
PURPOSE: To assess the relationship of dissociated optic nerve fiber layer (DONFL) and intraoperative membrane-peeling dynamics as visualized using intraoperative optical coherence tomography (OCT), and to evaluate the functional implications of DONFL. METHODS: This was a post hoc analysis of eyes undergoing membrane peeling for vitreomacular interface disorders in the prospective PIONEER intraoperative OCT study. Retinal layer measurements in preincision and postpeel intraoperative OCT images were obtained...
January 16, 2018: Retina
https://www.readbyqxmd.com/read/29346111/single-scan-high-resolution-2-d-j-resolved-spectroscopy-in-inhomogeneous-magnetic-fields
#8
Kaiyu Wang, Yuqing Huang, Pieter E S Smith, Zhiyong Zhang, Shuhui Cai, Zhong Chen
OBJECTIVE: A method is proposed to obtain high-resolution 2-D -resolved nuclear magnetic resonance (NMR) spectra in inhomogeneous magnetic fields. METHODS: The proposed experiment enables the acquisition of an entire 2-D spectrum in a single scan by utilizing intermolecular double-quantum coherences and the spatial encoding of NMR observables. RESULTS: Chemical shifts, coupling constants, and multiplet patterns are recovered even when field inhomogeneities are severe enough to completely obscure conventional NMR spectra...
February 2018: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/29346029/unifying-visual-space-across-the-left-and-right-hemifields
#9
Zhimin Chen, Anna Kosovicheva, Benjamin Wolfe, Patrick Cavanagh, Andrei Gorea, David Whitney
Visual space is perceived as continuous and stable even though visual inputs from the left and right visual fields are initially processed separately within the two cortical hemispheres. In the research reported here, we examined whether the visual system utilizes a dynamic recalibration mechanism to integrate these representations and to maintain alignment across the visual fields. Subjects adapted to randomly oriented moving lines that straddled the vertical meridian; these lines were vertically offset between the left and right hemifields...
January 1, 2018: Psychological Science
https://www.readbyqxmd.com/read/29345956/measuring-three-dimensional-strain-and-structural-defects-in-a-single-ingaas-nanowire-using-coherent-x-ray-multi-angle-bragg-projection-ptychography
#10
Megan O Hill, Irene Calvo-Almazan, Mark Allain, Martin Holt, Andrew Ulvestad, Julian Treu, Gregor Koblmueller, Chunyi Huang, Xiaojing Huang, Hanfei Yan, E Nazarestski, Yong S Chu, G Brian Stephenson, Virginie Chamard, Lincoln Lauhon, Stephan O Hruszkewycz
III-As nanowires are candidates for near infrared light emitters and detectors that can be directly integrated onto silicon. However, nanoscale to microscale variations in structure, composition, and strain within a given nanowire, as well as variations between nanowires, pose challenges to correlating microstructure with device performance. In this work, we utilize coherent nano-focused x-rays to characterize stacking defects and strain in a single InGaAs nanowire supported on Si. By reconstructing diffraction patterns from the 2-1-10 Bragg peak, we show that the lattice orientation varies along the length of the wire, while the strain field along the cross-section is largely unaffected, leaving the band structure unperturbed...
January 18, 2018: Nano Letters
https://www.readbyqxmd.com/read/29345539/working-memory-updating-load-and-binding
#11
Paola Palladino, Caterina Artuso
In the present study, we aimed to examine how specific objects are updated in working memory. We compared conditions in which contents or content-context bindings from working memory were both encoded and updated (Experiment 1). In addition, for bindings, we manipulated the memory load (i.e., number of contents) to maintain during updating. Results indicated that memory load did not specifically affect the process; rather, the content-context binding (vs. single contents) was critical in determining the increase in response latencies...
January 18, 2018: Journal of General Psychology
https://www.readbyqxmd.com/read/29345434/two-photon-excited-silica-and-organosilica-nanoparticles-for-spatiotemporal-cancer-treatment
#12
REVIEW
Jonas G Croissant, Jeffrey I Zink, Laurence Raehm, Jean-Olivier Durand
Coherent two-photon-excited (TPE) therapy in the near-infrared (NIR) provides safer cancer treatments than current therapies lacking spatial and temporal selectivities because it is characterized by a 3D spatial resolution of 1 µm3 and very low scattering. In this review, the principle of TPE and its significance in combination with organosilica nanoparticles (NPs) are introduced and then studies involving the design of pioneering TPE-NIR organosilica nanomaterials are discussed for bioimaging, drug delivery, and photodynamic therapy...
January 18, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29344739/what-we-have-learned-from-the-recent-meta-analyses-on-diagnostic-methods-for-atherosclerotic-plaque-regression
#13
REVIEW
Giuseppe Biondi-Zoccai, Simona Mastrangeli, Enrico Romagnoli, Mariangela Peruzzi, Giacomo Frati, Leonardo Roever, Arturo Giordano
PURPOSE OF REVIEW: Atherosclerosis has major morbidity and mortality implications globally. While it has often been considered an irreversible degenerative process, recent evidence provides compelling proof that atherosclerosis can be reversed. Plaque regression is however difficult to appraise and quantify, with competing diagnostic methods available. Given the potential of evidence synthesis to provide clinical guidance, we aimed to review recent meta-analyses on diagnostic methods for atherosclerotic plaque regression...
January 17, 2018: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29344490/capillary-dropout-a-novel-fluorescein-angiography-finding-in-primary-vitreoretinal-lymphoma
#14
Ramesh Venkatesh, Prachi Gurav, Prachi Abhishek Dave, Arpan Gandhi
Tissue diagnosis with vitreous and/or retinal biopsy usually confirms the diagnosis of primary vitreoretinal lymphoma. Multiple imaging modalities like fundus fluorescein angiography, fundus autofluorescence, and optical coherence tomography have been used to support the diagnosis of vitreoretinal lymphoma. We report a case of a 74-year-old lady diagnosed with primary vitreoretinal lymphoma showing a novel fluorescein angiographic finding of capillary dropout. We hypothesize that this clinical finding on the fluorescein angiogram may be due to the occlusion of the retinal vasculature by the malignant tumor cells...
November 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29344373/multianalysis-with-optical-coherence-tomography-and-vasomotion-in-everolimus-eluting-stents-and-everolimus-eluting-biovascular-scaffolds-the-moves-trial
#15
Diego A Arroyo, Sara Schukraft, Zacharenia Kallinikou, Jean-Christophe Stauffer, Gérard Baeriswyl, Jean-Jacques Goy, Mario Togni, Stéphane Cook, Serban Puricel
Aims: To compare endothelium-dependent vasomotor function and vascular healing 15 months after implantation of two new-generation drug-eluting stents and biovascular scaffolds (BVS). Methods and results: A total of 28 patients previously treated with a SYNERGY stent (bioabsorbable polymer everolimus-eluting stents (BP-EES)), a PROMUS stent (persistent polymer everolimus-eluting stents (PP-EES)) or an ABSORB (BVS) underwent control coronary angiography, 15 months after implantation, coupled with optical coherence tomography imaging and supine bicycle exercise...
2018: Open Heart
https://www.readbyqxmd.com/read/29344318/noninvasive-long-term-monitoring-of-actinic-keratosis-and-field-cancerization-following-treatment-with-ingenol-mebutate-gel-0-015
#16
Orit Markowitz, Katie Wang, Amanda Levine, Michelle Schwartz, Sumeet Minhas, Eleanor Feldman, Daniel M Siegel
OBJECTIVE: To determine whether actinic keratosis and photodamaged perilesional areas (field cancerization) treated successfully with topical ingenol mebutate gel 0.015% remained clear one year later, and to treat actinic keratosis and perilesional skin not treated one year earlier. DESIGN: Single-center, single-arm, open-label extension of an original clinical study completed one year earlier. SETTING: An outpatient clinic. PARTICIPANTS: Fifteen of the original 28 study patients enrolled in and who completed the extension phase...
October 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29344070/diffuse-colour-discrimination-as-marker-of-afferent-visual-system-dysfunction-in-amyotrophic-lateral-sclerosis
#17
Lindsay Boven, Qin Li Jiang, Heather E Moss
Abnormalities of the inner and intermediate retinal structures in patients with amyotrophic lateral sclerosis (ALS) have been described using optical coherence tomography and histopathology. Colour vision is a potential marker of these structural changes. The purpose of this study is to test the hypothesis that colour vision impairment is associated with ALS. Monocular (right eye) colour vision was assessed in subjects with definite or probable ALS (n = 25, aged 50-80 years) and control (n = 21, aged 46-89 years) subjects with corrected near visual acuity of at least 20/40 using the L'Anthony D15 color test (desaturated), scored by c-index, a measure of diffuse colour discrimination...
December 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29344064/occult-acute-macular-neuroretinopathy
#18
Michael S Vaphiades, Brendan Grondines
A 19-year-old Caucasian woman developed an upper respiratory infection, took a cold formulation containing 5 mg of phenylephrine, and developed a very rare and unusual form of acute macular neuroretinopathy (AMN) that could not be detected on fundoscopic examination, visual fields, nor electrophysiological testing. Spectral-domain optical coherence tomography (SD-OCT) revealed a lesion limited to the fovea. This case illustrates the value of SD-OCT, in light of otherwise normal testing, in a variant of AMN the authors call "occult AMN"...
August 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29343802/loss-induced-coherent-combining-in-inp-si3n4-hybrid-platform
#19
Yeyu Zhu, Yunsong Zhao, Lin Zhu
Loss, as a time-reversed counterpart of gain, can also be used to control lasing in an optical system with coupled cavities. In this study, by manipulating mirror losses at different output ports of coupled Fabry-Perot cavities, an integrated coherently combined laser system is proposed and experimentally demonstrated in the InP-Si3N4 hybrid platform. Two InP-based reflective semiconductor amplifiers are coherently combined through an adiabatic 50:50 directional coupler in silicon nitride. The combining efficiency is ~92% at ~2× threshold...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343790/interference-experiment-with-asymmetric-double-slit-by-using-1-2-mv-field-emission-transmission-electron-microscope
#20
Ken Harada, Tetsuya Akashi, Kodai Niitsu, Keiko Shimada, Yoshimasa A Ono, Daisuke Shindo, Hiroyuki Shinada, Shigeo Mori
Advanced electron microscopy technologies have made it possible to perform precise double-slit interference experiments. We used a 1.2-MV field emission electron microscope providing coherent electron waves and a direct detection camera system enabling single-electron detections at a sub-second exposure time. We developed a method to perform the interference experiment by using an asymmetric double-slit fabricated by a focused ion beam instrument and by operating the microscope under a "pre-Fraunhofer" condition, different from the Fraunhofer condition of conventional double-slit experiments...
January 17, 2018: Scientific Reports
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