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Cancer Surveillance

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https://www.readbyqxmd.com/read/28641390/racial-and-ethnic-disparities-in-the-incidence-of-esophageal-cancer-in-the-united-states-1992-2013
#1
Shao-Hua Xie, Sirus Rabbani, Jessica Petrick, Michael B Cook, Jesper Lagergren
Racial and ethnic disparities in the incidence of esophageal cancer have not been thoroughly characterized with quantitative health disparity measures. Using data from 13 cancer registries in the Surveillance, Epidemiology, and End Results database, we assessed such disparities by histological type during 1992-2013 in the United States based on a variety of disparity metrics. The age-standardized incidence rate of squamous cell carcinoma was highest among blacks, while adenocarcinoma mainly affected white men...
June 21, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28637082/positive-aspects-of-having-had-cancer-a-mixed-methods-analysis-of-responses-from-the-american-cancer-society-survivors-of-cancer-ii-studies
#2
Gail Adorno, Ellen Lopez, Mary Ann Burg, Victoria Loerzel, Michael Killian, Amy B Dailey, Joanne D Iennaco, Cara Wallace, Dinghy Kristine B Sharma, Kevin Stein
PURPOSE: This study focused on understanding positive aspects of cancer amongst a large, national sample of survivors, two, five, and ten years' post-cancer diagnosis, who responded to the American Cancer Society Survivors of Cancer-II survey question "Please tell us about any positive aspects of having cancer." METHODS: A sequential mixed methods approach examined 1) thematic categories of positive aspects from cancer survivors (n = 5149) and 2) variation in themes by sociodemographics, cancer type, stage of disease, and length of survivorship...
June 21, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28637020/autophagy-related-genes-are-induced-by-histone-deacetylase-inhibitor-suberoylanilide-hydroxamic-acid-via-the-activation-of-cathepsin-b-in-human-breast-cancer-cells
#3
Han Han, Jing Li, Xiuyan Feng, Hui Zhou, Shanchun Guo, Weiqiang Zhou
Autophagy is involved in modulating tumor cell motility and invasion, resistance to epithelial-to-mesenchymal transition, anoikis, and escape from immune surveillance. We have previous shown that SAHA is capable to induce several apoptosis and autophagy-related gene expression in breast cancers. However, the exact mechanisms of autophagy activation in this context have not been fully identified. Our results showed that the expression and the activity of Cathepsin B (CTSB), one of the major lysosomal cysteine proteases, were significantly increased in MDA-MB- 231 and MCF-7 cells upon SAHA treatment...
June 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28636999/impact-of-insurance-status-on-the-survival-of-gallbladder-cancer-patients
#4
Zhiqiang Chen, Wen Gao, Liyong Pu, Long Zhang, Guoyong Han, Qin Zhu, Xiangcheng Li, Jindao Wu, Xuehao Wang
The prognostic significance of insurance status has been investigated in many types of malignancies, however, its impact on gallbladder cancer is yet not known. The purpose of this study was to determine the relationship between insurance status and gallbladder cancer survival. We searched the Surveillance, Epidemiology, and End Results dataset, and identified 1,729 gallbladder cancer cases. Kaplan-Meier methods and multivariable Cox regression models were used to analyze survival outcomes and risk factors...
June 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28636983/the-influence-of-marital-status-on-survival-in-patients-with-oral-tongue-squamous-cell-carcinoma
#5
Wei Sun, Zeting Qiu, Wulin Tan, Zhongqi Liu, Zhongxing Wang, Wenqi Huang, Minghui Cao
Marital status was found to be an independent prognostic factor for survival in several cancers. However related researches of oral tongue squamous cell carcinoma (OTSCC) are still rare. We explored the Surveillance, Epidemiology, and End Results (SEER) program and finally identified 14,194 patients with OTSCC. Kaplan-Meier analysis and multivariate Cox regression models were used to distinguish risk factors for overall survival (OS) and tumor cause-specific survival (TCSS). Widowed patients had the highest percentage of female, highest average ages and more prevalence with localized SEER Stage significantly, while patients in the single group were younger than other groups...
June 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28636713/practice-vs-physician-level-variation-in-use-of-active-surveillance-for-men-with-low-risk-prostate-cancer-implications-for-collaborative-quality-improvement
#6
Gregory B Auffenberg, Brian R Lane, Susan Linsell, Michael L Cher, David C Miller
No abstract text is available yet for this article.
June 21, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28636692/rethinking-the-current-american-joint-committee-on-cancer-tnm-staging-system-for-medullary-thyroid-cancer
#7
Mohamed Abdelgadir Adam, Samantha Thomas, Sanziana A Roman, Terry Hyslop, Julie A Sosa
Importance: Controversy exists around the American Joint Committee on Cancer (AJCC) TNM staging system for medullary thyroid cancer (MTC). Because of the rarity of the disease and limited available data, the staging system for MTC has been largely extrapolated from staging for differentiated thyroid cancer. Objectives: To evaluate how well the current (seventh and eighth editions) AJCC TNM staging system correlates with survival for patients with MTC and to suggest a possible revision...
June 21, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28636557/surgical-management-for-follicular-variant-of-papillary-thyroid-carcinoma
#8
Jianing Tang, Deguang Kong, Lupin Bu, Gaosong Wu
BACKGROUND AND AIMS: For most patients with follicular variant of papillary thyroid carcinoma (FVPTC), surgery is required, while the surgical management remains controversial. We aim to further understanding of treatment of FVPTC and to determine whether specific features could be identified for the decision of surgical strategy. MATERIALS AND METHODS: Data were obtained from the Surveillance, Epidemiology, and End Results (SEER) Program database during 2003 and 2013...
June 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28636295/-screening-of-ovarian-cancer-not-for-tomorrow
#9
Aurélie Vuilleumier, Intidhar Labidi-Galy
As the worldwide incidence of cancer continuously rises, one of the measures to reduce mortality is early diagnosis while the disease is still curable. Colonoscopy screening and PAP-smears are worthwhile examples illustrating the impact of early diagnosis on mortality. Ovarian cancer is the first cause of mortality by gynecological cancers in Switzerland (incidence of 600 new cases / year), mostly diagnosed at advanced stages with a poor prognosis. Could surveillance measures improve survival ? Three large-scale randomized control trials failed to show mortality reduction from ovarian cancer with the methods currently available...
May 17, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28635333/molecular-biomarkers-to-guide-precision-medicine-in-localized-prostate-cancer
#10
Minke Smits, Niven Mehra, Michiel Sedelaar, Winald Gerritsen, Jack A Schalken
Major advances through tumor profiling technologies, that include next-generation sequencing, epigenetic, proteomic and transcriptomic methods, have been made in primary prostate cancer, providing novel biomarkers that may guide precision medicine in the near future. Areas covered: The authors provided an overview of novel molecular biomarkers in tissue, blood and urine that may be used as clinical tools to assess prognosis, improve selection criteria for active surveillance programs, and detect disease relapse early in localized prostate cancer...
June 21, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28634755/rhabdomyosarcoma-of-the-lower-female-genital-tract-an-analysis-of-144-cases
#11
Dimitrios Nasioudis, Michail Alevizakos, Eloise Chapman-Davis, Steven S Witkin, Kevin Holcomb
PURPOSE: The aim of the present study was to elucidate the clinico-pathological characteristics of female patients with lower genital tract rhabdomyosarcoma (RMS) stratified by age group and investigate their prognosis, using a multi-institutional database. METHODS: The National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database was accessed (1973-2013) and a cohort of females diagnosed with RMS of the lower genital tract (vulva, vagina, cervix) was drawn...
June 20, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28634670/surveillance-of-the-patients-with-high-risk-of-hepatocellular-cancer
#12
REVIEW
Necati Örmeci
No abstract text is available yet for this article.
June 20, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28634645/comparative-evaluation-of-preliminary-screening-methods-for-colorectal-cancer-in-a-mass-program
#13
Ding Ye, Qiuchi Huang, Qilong Li, Xiyi Jiang, Mayila Mamat, Mengling Tang, Jianbing Wang, Kun Chen
BACKGROUND: The fecal immunochemical test (FIT) has been widely used in preliminary screening for colorectal cancer (CRC). The high-risk factor questionnaire (HRFQ) and quantitative risk-assessment method (QRAM) are recommended for estimating the risk of CRC qualitatively and quantitatively in China. AIM: We aimed to prospectively compare the diagnostic values of CRC preliminary screening methods to identify which method is preferable as a screening strategy. METHODS: Individuals aged 40-74 years old were enrolled in a mass CRC screening program from January 1, 2007 to December 31, 2014, in Jiashan County, Zhejiang Province, China...
June 20, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28633444/controversies-in-the-management-of-low-risk-differentiated-thyroid-cancer
#14
Megan R Haymart, Nazanene H Esfandiari, Michael T Stang, Julia Ann Sosa
Controversy exists over optimal management of low-risk differentiated thyroid cancer. This controversy occurs in all aspects of management including surgery, use of radioactive iodine for remnant ablation, thyroid hormone supplementation, and long-term surveillance. Limited and conflicting data, treatment paradigm shifts, and differences in physician perceptions contribute to the controversy. This lack of physician consensus results in wide variation in patient care, with some patients at risk for over or undertreatment...
June 19, 2017: Endocrine Reviews
https://www.readbyqxmd.com/read/28633040/hematopoietic-cell-transplantation-training-challenges-and-potential-opportunities-through-networking-and-integration-of-modern-technologies-to-the-practice-setting
#15
REVIEW
Mohamed A Kharfan-Dabaja, Mahmoud Aljurf
Hematopoietic cell transplantation (HCT), particularly allogeneic HCT, is a complex and a high-risk procedure requiring expertise to manage potential treatment complications. Published data supports the value of quality management systems in improving post-transplant outcomes; however, there are no universally established, or agreed upon, criteria to assess adequacy of training of physicians, transplant or nontransplant, and supporting staff, among others. It is of paramount importance for transplant centers to identify the needed area(s) of expertise in order to seek appropriate training for their staff...
June 13, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28632726/infradiaphragmatic-irradiation-and-high-procarbazine-doses-increase-colorectal-cancer-risk-in-hodgkin-lymphoma-survivors
#16
Anna M van Eggermond, Michael Schaapveld, Cécile Pm Janus, Jan Paul de Boer, Augustinus Dg Krol, Josée M Zijlstra, Richard Wm van der Maazen, Leontien C Kremer, Monique E van Leerdam, Marieke Wj Louwman, Otto Visser, Marie L De Bruin, Berthe Mp Aleman, Flora E van Leeuwen
BACKGROUND: Hodgkin lymphoma (HL) survivors are at increased risk of second malignancies, but few studies have assessed colorectal cancer (CRC) risk after HL treatment. We assessed long-term, subsite-specific CRC risk associated with specific radiation fields and chemotherapy regimens. METHODS: In a Dutch cohort of 3121 5-year HL survivors treated between 1965 and 1995, subsite-specific CRC incidence was compared with general population rates. Treatment effects were quantified by Cox regression analyses...
June 20, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28632505/obesity-and-prostate-cancer
#17
Marco Bandini, Giorgio Gandaglia, Alberto Briganti
PURPOSE OF REVIEW: To investigate the association between obesity and prostate cancer (PCa). RECENT FINDINGS: Obesity has been proposed to be involved in the pathogenesis of PCa through different biological mechanisms that include deregulation of the insulin axis, sex hormone secretion, adipokines signaling, and oxidative stress. Hypertrophic peritumoral adipocytes may also facilitate the local spread of PCa through the chemo-attraction of tumor cells. Clinical studies demonstrate that obesity might have clinical implications also in disease detection and management...
June 16, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28631160/role-of-imaging-in-the-follow-up-of-t2-t3-glottic-cancer-treated-by-transoral-laser-microsurgery
#18
Filippo Marchi, Cesare Piazza, Marco Ravanelli, Giovanna Gaggero, Giampiero Parrinello, Alberto Paderno, Pietro Perotti, Marta Filauro, Roberto Maroldi, Giorgio Peretti
An unblinded retrospective analysis of prospectively collected data was carried out on 138 patients affected by glottic pT2 and selected pT3 squamous cell carcinomas (SCC) treated by transoral laser microsurgery (TLM). The entire cohort was divided into two groups: Group A included 78 "high-risk" patients (pT2 with impaired vocal cord mobility, pT3 for anterior paraglottic and/or pre-epiglottic space invasion, presence of angioembolization, perineural spread, and positive lymph nodes in the neck) who underwent postoperative surveillance by endoscopy and imaging (CT or MR), while Group B included 60 "low-risk" patients (pT2 with absence of the above-mentioned features) who underwent endoscopic follow-up alone...
June 19, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28631086/nearly-a-third-of-high-grade-dysplasia-and-colorectal-cancer-is-undetected-in-patients-with-inflammatory-bowel-disease
#19
Swathi Eluri, Alyssa M Parian, Berkeley N Limketkai, Christina Y Ha, Steven R Brant, Sharon Dudley-Brown, Jonathan E Efron, Sandy G Fang, Susan L Gearhart, Michael R Marohn, Stephen J Meltzer, Safar Bashar, Brindusa Truta, Elizabeth A Montgomery, Mark G Lazarev
BACKGROUND: It is unclear whether intensive surveillance protocols have resulted in a decreased incidence of colorectal cancer (CRC) in inflammatory bowel disease (IBD). AIMS: To determine the prevalence and characteristics of IBD associated high-grade dysplasia (HGD) or CRC that was undetected on prior colonoscopy. METHODS: This is a single-center, retrospective study from 1994 to 2013. All participants had a confirmed IBD diagnosis and underwent a colectomy with either HGD or CRC found in the colectomy specimen...
June 19, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28629785/-interest-using-3d-ultrasound-and-mri-fusion-biopsy-for-prostate-cancer-detection
#20
A Marien, A De Castro Abreu, I Gill, A Villers, O Ukimura
INTRODUCTION: The strategic therapy for prostate cancer depends on histo-pronostics data, which could be upgraded by obtaining targeted biopsies (TB) with MRI (magnetic resonance imagery) fusion 3D ultrasound. OBJECTIVES: To compare diagnostic yield of image fusion guided prostate biopsy using image fusion of multi-parametric MRI (mpMRI) with 3D-TRUS. MATERIALS AND METHODS: Between January 2010 and April 2013, 179 consecutive patients underwent outpatient TRUS biopsy using the real-time 3D TRUS tracking system (Urostation™)...
June 16, 2017: Progrès en Urologie
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