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Cancer Surveillance

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https://www.readbyqxmd.com/read/28743160/the-prognostic-utility-of-baseline-alpha-fetoprotein-for-hepatocellular-carcinoma-patients
#1
Jack P Silva, Richard A Gorman, Nicholas G Berger, Susan Tsai, Kathleen K Christians, Callisia N Clarke, Harveshp Mogal, T Clark Gamblin
INTRODUCTION: Alpha-fetoprotein (AFP) has a valuable role in postoperative surveillance for hepatocellular carcinoma (HCC) recurrence. The utility of pretreatment or baseline AFP remains controversial. The present study hypothesized that elevated baseline AFP levels are associated with worse overall survival in HCC patients. METHODS: Adult HCC patients were identified using the National Cancer Database (2004-2013). Patients were stratified according to baseline AFP measurements into the following groups: Negative (<20), Borderline (20-199), Elevated (200-1999), and Highly Elevated (>2000)...
July 25, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28741059/postoperative-follow-up-programs-improve-survival-in-curatively-resected-gastric-and-junctional-cancer-patients-a-propensity-score-matched-analysis
#2
Leila Sisic, Moritz J Strowitzki, Susanne Blank, Henrik Nienhueser, Sara Dorr, Georg Martin Haag, Dirk Jäger, Katja Ott, Markus W Büchler, Alexis Ulrich, Thomas Schmidt
BACKGROUND: To date there is no evidence that more intensive follow-up after surgery for esophagogastric adenocarcinoma translates into improved survival. This study aimed to evaluate the impact of standardized surveillance by a specialized center after resection on survival. METHODS: Data of 587 patients were analyzed who underwent curative surgery for esophagogastric adenocarcinoma in our institution. Based on their postoperative surveillance, patients were assigned to either standardized follow-up (SFU) by the National Center for Tumor Diseases (SFU group) or individual follow-up by other physicians (non-SFU group)...
July 24, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/28740904/disparities-in-staging-prostate-magnetic-resonance-imaging-utilization-for-nonmetastatic-prostate-cancer-patients-undergoing-definitive-radiation-therapy
#3
Ayobami Ajayi, Wei-Ting Hwang, Neha Vapiwala, Mark Rosen, Christina H Chapman, Stefan Both, Meera Shah, Xingmei Wang, Atu Agawu, Peter Gabriel, John Christodouleas, Zelig Tochner, Curtiland Deville
PURPOSE: There is growing evidence supporting incorporating multiparametric (mp) magnetic resonance imaging (MRI) scans into risk stratification, active surveillance, and treatment paradigms for prostate cancer. The purpose of our study was to determine whether demographic disparities exist in staging MRI utilization for prostate cancer patients. METHODS AND MATERIALS: An institutional database of 705 nonmetastatic prostate cancer patients treated with radiation therapy from 2005 through 2013 was used to identify patients undergoing versus not undergoing pretreatment diagnostic prostate mpMRI...
October 2016: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28739770/gastric-cancer-mortality-trends-in-china-2006-2013-reveal-increasing-mortality-in-young-subjects
#4
Jie Yin, Jian-Ning Song, Zhi-Gang Bai, Jun Cai, Jun Zhang, Zhi Zheng, Hong-Wei Wu, Peng-Peng Ye, Xin Gao, Zhong-Tao Zhang
BACKGROUND/AIM: Although the advent of Helicobacter pylori eradication and global societal changes are widely assumed to impact on gastric cancer (GC)-related mortality, there is remarkable little quantitative and qualitative insight into the nature of its effects. Here, we exploited a nationwide reporting system to investigate the epidemiological features of GC-related mortality in China between 2006 and 2013. PATIENTS AND METHODS: GC mortality data between 2006 and 2013 were obtained from the National Disease Surveillance System published by the China Center for Disease Control and Prevention (CDC)...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739621/lipoma-of-superior-vena-cava-a-rare-occurrence
#5
Ahsan Wahab, Siddique Chaudhary, Ahmad Munir, Susan Jane Smith
Most benign primary cardiac tumours are myxomas; non-myxomatous tumours are less common but comprise a wide variety. Cardiac lipoma is a rare non-myxomatous variety. A 70-year-old Caucasian woman with right breast cancer status postpartial mastectomy underwent surveillance MRI of the breast and was found to have a possible right atrial (RA) mass. She also reported frequent headaches and palpitations. She underwent a transoesophageal echocardiogram which showed a 2.6×1.6×1.6 cm echogenic mass at the superior vena cava (SVC) and RA junction...
July 24, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28739405/the-burden-of-cystoscopic-bladder-cancer-surveillance-anxiety-discomfort-and-patient-preferences-for-decision-making
#6
Kevin Koo, Lisa Zubkoff, Brenda E Sirovich, Philip P Goodney, Douglas J Robertson, John D Seigne, Florian R Schroeck
Objective To examine discomfort, anxiety, and preferences for decision-making in patients undergoing surveillance cystoscopy for non-muscle-invasive bladder cancer (NMIBC). Methods Veterans with a prior diagnosis of NMIBC completed validated survey instruments assessing procedural discomfort, worry, and satisfaction, and were invited to participate in semi-structured focus groups about their experience and desire to be involved in surveillance decision-making. Focus group transcripts were analyzed qualitatively, using (1) systematic iterative coding, (2) triangulation involving multiple perspectives from urologists and an implementation scientist, and (3) searching and accounting for disconfirming evidence...
July 21, 2017: Urology
https://www.readbyqxmd.com/read/28739282/long-term-risk-of-pancreatic-malignancy-in-patients-with-branch-duct-intraductal-papillary-mucinous-neoplasm-in-a-referral-center
#7
Ilaria Pergolini, Klaus Sahora, Cristina R Ferrone, Vicente Morales-Oyarvide, Brian M Wolpin, Lorelei A Mucci, William R Brugge, Mari Mino-Kenudson, Manuel Patino, Dushyant V Sahani, Andrew L Warshaw, Keith D Lillemoe, Carlos Fernández-Del Castillo
BACKGROUND & AIMS: Little is known about development of branch duct intraductal papillary mucinous neoplasms (BD-IPMNs). We evaluated long-term outcomes of a large cohort of patients with BD-IPMNs to determine risk of malignancy and define a subset of low-risk BD-IPMNs. METHODS: We performed a retrospective analysis of data from 577 patients with suspected or presumed BD-IPMN under surveillance at the Massachusetts General Hospital. Patients underwent cross-sectional imaging analysis at 3 months or later after their initial diagnosis...
July 21, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28738408/cgas-surveillance-of-micronuclei-links-genome-instability-to-innate-immunity
#8
Karen J Mackenzie, Paula Carroll, Carol-Anne Martin, Olga Murina, Adeline Fluteau, Daniel J Simpson, Nelly Olova, Hannah Sutcliffe, Jacqueline K Rainger, Andrea Leitch, Ruby T Osborn, Ann P Wheeler, Marcin Nowotny, Nick Gilbert, Tamir Chandra, Martin A M Reijns, Andrew P Jackson
DNA is strictly compartmentalized within the nucleus to prevent autoimmunity; despite this, cyclic GMP-AMP synthase (cGAS), a cytosolic sensor of double-stranded DNA, is activated in autoinflammatory disorders and by DNA damage. Precisely how cellular DNA gains access to the cytoplasm remains to be determined. Here, we report that cGAS localizes to micronuclei arising from genome instability in a mouse model of monogenic autoinflammation, after exogenous DNA damage and spontaneously in human cancer cells. Such micronuclei occur after mis-segregation of DNA during cell division and consist of chromatin surrounded by its own nuclear membrane...
July 24, 2017: Nature
https://www.readbyqxmd.com/read/28736862/quality-management-of-ultrasound-surveillance-for-hepatocellular-carcinoma-under-the-korean-national-cancer-screening-program
#9
Moon Hyung Choi, Seung Eun Jung, Joon-Il Choi, Woo Kyoung Jeong, Hyun Cheol Kim, Yongsoo Kim, Yeol Kim, Boyoung Park
OBJECTIVES: The aim of this study was to investigate the quality of ultrasound (US) examinations for hepatocellular carcinoma surveillance under the Korean National Cancer Screening Program and to assess knowledge and experience about liver US of physicians who perform US examinations. METHODS: The investigation about the quality of liver US for hepatocellular carcinoma screening was based on the results of a nationwide quality assurance (QA) evaluation between 2012 and 2014 at all medical institutions participating in the National Cancer Screening Program...
July 24, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28736658/3d-reconstruction-of-cystoscopy-videos-for-comprehensive-bladder-records
#10
Kristen L Lurie, Roland Angst, Dimitar V Zlatev, Joseph C Liao, Audrey K Ellerbee Bowden
White light endoscopy is widely used for diagnostic imaging of the interior of organs and body cavities, but the inability to correlate individual 2D images with 3D organ morphology limits its utility for quantitative or longitudinal studies of disease physiology or cancer surveillance. As a result, most endoscopy videos, which carry enormous data potential, are used only for real-time guidance and are discarded after collection. We present a computational method to reconstruct and visualize a 3D model of organs from an endoscopic video that captures the shape and surface appearance of the organ...
April 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28736649/neoadjuvant-transarterial-radiation-lobectomy-for-colorectal-hepatic-metastases-a-small-cohort-analysis-on-safety-efficacy-and-radiopathologic-correlation
#11
Jehan L Shah, Ivan R Zendejas-Ruiz, Linday M Thornton, Brian S Geller, Joseph R Grajo, Amy Collinsworth, Thomas J George, Beau Toskich
Colorectal cancer patients have a high incidence of liver metastasis (ml-CRC). Surgical resection is the gold standard for treatment of hepatic metastasis but only a small percent of patients are traditional candidates based on disease extent and adequate size of the future liver remnant (FLR). Interventions such as portal vein embolization (PVE) and associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) are performed to increase FLR for operative conversion. Limitations to PVE include intrahepatic disease progression, portal vascular invasion, and utilization with concurrent chemotherapy...
June 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28736506/national-disability-adjusted-life-years-dalys-for-257-diseases-and-injuries-in-ethiopia-1990-2015-findings-from-the-global-burden-of-disease-study-2015
#12
Awoke Misganaw, Yohannes Adama Melaku, Gizachew Assefa Tessema, Amare Deribew, Kebede Deribe, Semaw Ferede Abera, Muluken Dessalegn, Yihunie Lakew, Tolesa Bekele, Tilahun N Haregu, Azmeraw T Amare, Molla Gedefaw, Mesoud Mohammed, Biruck Desalegn Yirsaw, Solomon Abrha Damtew, Tom Achoki, Jed Blore, Kristopher J Krohn, Yibeltal Assefa, Mahlet Kifle, Mohsen Naghavi
BACKGROUND: Disability-adjusted life years (DALYs) provide a summary measure of health and can be a critical input to guide health systems, investments, and priority-setting in Ethiopia. We aimed to determine the leading causes of premature mortality and disability using DALYs and describe the relative burden of disease and injuries in Ethiopia. METHODS: We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015) for non-fatal disease burden, cause-specific mortality, and all-cause mortality to derive age-standardized DALYs by sex for Ethiopia for each year...
2017: Population Health Metrics
https://www.readbyqxmd.com/read/28736249/identifying-intermediate-risk-candidates-for-active-surveillance-of-prostate-cancer
#13
Richard Savdie, Jonathan Aning, Alan I So, Peter C Black, Martin E Gleave, S Larry Goldenberg
PURPOSE: Although already established for very-low and low-risk (LR) prostate cancer (PCa), controversy remains around offering active surveillance (AS) to men with intermediate-risk (IR) PCa. As IR represents a broad spectrum of disease biology, there is a critical need to define eligibility criteria that will enable both patient and physician to accept AS as the best balance of competing risks. In this study, we aimed to identify predictors of progression to enable optimal patient selection...
July 20, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28736138/how-viral-genetic-variants-and-genotypes-influence-disease-and-treatment-outcome-of-chronic-hepatitis-b-time-for-an-individualized-approach
#14
REVIEW
Neil Rajoriya, Christophe Combet, Fabien Zoulim, Harry L A Janssen
Chronic hepatitis B virus (HBV) infection remains a global problem. Several HBV (sub)genotypes exist with different biology and geographical preponderances. While the future aim of HBV treatment remains virus eradication, current strategies of treatment aim to suppress the virus and prevent the progression of liver disease. Current strategies also involve identification of patients for treatment - those at risk of progressive liver disease. Identification of HBV genotype, HBV mutants and other predictive factors allow for tailored treatments, and also risk-surveillance pathways such as for hepatocellular cancer screening...
July 20, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28735257/prognostic-factors-of-overall-survival-and-cancer-specific-survival-in-patients-with-resected-early-stage-rectal-adenocarcinoma-a-seer-based-study
#15
Ko-Chao Lee, Kuan-Chih Chung, Hong-Hwa Chen, Chia-Cheng Liu, Chien-Chang Lu
The benefits of radiotherapy for colorectal cancer are well documented, but the impact of adjuvant radiotherapy on early-stage rectal adenocarcinoma remains unclear. This study aimed to identify predictors of overall survival (OS) and cancer-specific survival (CSS) in patients with stage II rectal adenocarcinoma treated with preoperative or postoperative radiation therapy. Patients with early-stage rectal adenocarcinoma in the postoperative state were identified using the Surveillance, Epidemiology, and End Results database...
July 21, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28734542/improved-survival-after-retrieval-of-12-or-more-regional-lymph-nodes-in-appendiceal-cancer
#16
I Fleischmann, R Warschkow, U Beutner, L Marti, B M Schmied, T Steffen
BACKGROUND: To evaluate the role of regional lymph node (RLN) retrieval on stage migration, overall (OS), and cancer-specific survival (CSS) in appendiceal cancer. METHODS: Between 2004 and 2012, 1046 patients with primary stage I-III carcinoma of the appendix were identified in the Surveillance, Epidemiology and End Results database. The impact of the number of RLN removed on OS and CSS was assessed using joinpoint regression, Cox regression, and propensity score methods...
July 15, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28734496/endometrial-cancer-surveillance-adherence-reduces-utilization-and-subsequent-costs
#17
Zachary P Schwartz, Melissa K Frey, Sarah Philips, John P Curtin
OBJECTIVES: In June 2011, the SGO recommended that physical exam and symptoms be the primary surveillance methods in patients with endometrial cancer. We sought to evaluate adherence to these guidelines by comparing the use of CT scans, paps and serum CA125 ordered for endometrial cancer surveillance before and after publication of these guidelines. METHODS: A retrospective review was performed for all patients undergoing surveillance for endometrial cancer at a single institution between June 2009 and June 2013...
July 19, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28734233/risk-of-hospitalization-among-survivors-of-childhood-and-adolescent-acute-lymphoblastic-leukemia-compared-to-siblings-and-a-general-population-sample
#18
Judy Y Ou, Rochelle R Smits-Seemann, Sapna Kaul, Mark N Fluchel, Carol Sweeney, Anne C Kirchhoff
BACKGROUND: Acute Lymphoblastic Leukemia (ALL) has a high survival rate, but cancer-related late effects in the early post-treatment years need documentation. Hospitalizations are an indicator of the burden of late effects. We identify rates and risk factors for hospitalization from five to ten years after diagnosis for childhood and adolescent ALL survivors compared to siblings and a matched population sample. METHODS: 176 ALL survivors were diagnosed at ≤22 years between 1998 and 2008 and treated at an Intermountain Healthcare facility...
July 19, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28734019/association-between-androgen-deprivation-therapy-and-anxiety-among-78-000-patients-with-localized-prostate-cancer
#19
Kathryn T Dinh, David D Yang, Kevin T Nead, Gally Reznor, Quoc-Dien Trinh, Paul L Nguyen
OBJECTIVES: To examine whether any androgen deprivation therapy use or longer duration is associated with an increased risk of anxiety in patients with prostate cancer. METHODS: We identified 78 552 men aged ≥66 years with stage I-III prostate cancer using the Surveillance, Epidemiology, and End Results-Medicare linked database from 1992 to 2006, excluding patients with psychiatric diagnoses within the year prior or 6 months after prostate cancer diagnosis. Multivariable Cox regression was used to examine the association between pharmacological androgen deprivation therapy and diagnosis of anxiety...
July 22, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28733870/rethinking-childhood-ependymoma-a-retrospective-multi-center-analysis-reveals-poor-long-term-overall-survival
#20
Amanda E Marinoff, Clement Ma, Dongjing Guo, Matija Snuderl, Karen D Wright, Peter E Manley, Hasan Al-Sayegh, Claire E Sinai, Nicole J Ullrich, Karen Marcus, Daphne Haas-Kogan, Liliana Goumnerova, Wendy B London, Mark W Kieran, Susan N Chi, Jason Fangusaro, Pratiti Bandopadhayay
Ependymoma is the third most common brain tumor in children, but there is a paucity of large studies with more than 10 years of follow-up examining the long-term survival and recurrence patterns of this disease. We conducted a retrospective chart review of 103 pediatric patients with WHO Grades II/III intracranial ependymoma, who were treated at Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Chicago's Ann & Robert H. Lurie Children's Hospital between 1985 and 2008, and an additional 360 ependymoma patients identified from the Surveillance Epidemiology and End Results (SEER) database...
July 21, 2017: Journal of Neuro-oncology
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