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https://www.readbyqxmd.com/read/29304080/local-vs-systemic-administration-of-bisphosphonates-in-rat-cleft-bone-graft-a-comparative-study
#1
Christine Hong, Alison Quach, Lawrence Lin, Jeffrey Olson, Taewoo Kwon, Olga Bezouglaia, Jaime Tran, Michael Hoang, Kimberly Bui, Reuben H Kim, Sotirios Tetradis
A majority of patients with orofacial cleft deformity requires cleft repair through a bone graft. However, elevated amount of bone resorption and subsequent bone graft failure remains a significant clinical challenge. Bisphosphonates (BPs), a class of anti-resorptive drugs, may offer great promise in enhancing the clinical success of bone grafting. In this study, we compared the effects of systemic and local delivery of BPs in an intraoral bone graft model in rats. We randomly divided 34 female 20-week-old Fischer F344 Inbred rats into four groups to repair an intraoral critical-sized defect (CSD): (1) Control: CSD without graft (n = 4); (2) Graft/Saline: bone graft with systemic administration of saline 1 week post-operatively (n = 10); (3) Graft/Systemic: bone graft with systemic administration of zoledronic acid 1 week post-operatively (n = 10); and (4) Graft/Local: bone graft pre-treated with zoledronic acid (n = 10)...
2018: PloS One
https://www.readbyqxmd.com/read/29168936/does-cbct-alter-the-diagnostic-thinking-efficacy-management-and-prognosis-of-patients-with-suspected-stage-0-medication-related-osteonecrosis-of-the-jaws
#2
Hiroaki Shimamoto, Tristan R Grogan, Tomomi Tsujimoto, Naoya Kakimoto, Shumei Murakami, David Elashoff, Tara L Aghaloo, Sotirios Tetradis
OBJECTIVES: To evaluate the impact of CBCT in the diagnostic thinking efficacy, management and prognosis of patients with suspected stage 0 medication-related osteonecrosis of the jaw (MRONJ). METHODS: For 15 patients with suspected stage 0 MRONJ, clinical photographs, a panoramic radiograph and selected CBCT sections were identified. 13 oral surgeons reviewed the material and answered 10 questions in two different sessions. First session included clinical photographs and panoramic radiographs, while second session also included CBCT images...
November 23, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/29157550/imaging-of-radiation-and-medication-related-osteonecrosis
#3
REVIEW
Sanjay M Mallya, Sotirios Tetradis
Osteonecrosis is the devitalization of bone and consequent lytic changes. In the jaws, osteonecrosis is a pathologic consequence of prior radiation therapy (osteoradionecrosis) or certain antiresorptive medications. Herein, we review the pathogenesis and clinical manifestations of these lesions, and describe the spectrum of radiologic findings in these conditions, and highlight the similarities and differences between the imaging appearances of these 2 entities.
January 2018: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/29093150/should-student-evaluation-of-teaching-play-a-significant-role-in-the-formal-assessment-of-dental-faculty-two-viewpoints-viewpoint-1-formal-faculty-assessment-should-include-student-evaluation-of-teaching-and-viewpoint-2-student-evaluation-of-teaching-should
#4
Susan Rowan, Elmer J Newness, Sotirios Tetradis, Joanne L Prasad, Ching-Chang Ko, Arlene Sanchez
Student evaluation of teaching (SET) is often used in the assessment of faculty members' job performance and promotion and tenure decisions, but debate over this use of student evaluations has centered on the validity, reliability, and application of the data in assessing teaching performance. Additionally, the fear of student criticism has the potential of influencing course content delivery and testing measures. This Point/Counterpoint article reviews the potential utility of and controversy surrounding the use of SETs in the formal assessment of dental school faculty...
November 2017: Journal of Dental Education
https://www.readbyqxmd.com/read/29064761/comparing-the-healing-potential-of-late-stage-periodontitis-and-peri-implantitis
#5
Ryan Wong, Sarah Hiyari, Aline Yaghsezian, Mina Davar, Yi-Ling Lin, Maria Galvan, Sotirios Tetradis, Paulo M Camargo, Flavia Q Pirih
Peri-implantitis is defined as an inflammatory disease affecting the tissues around osseointegrated functioning implants. Unfortunately, detailed PI pathogenesis is not well understood and current treatments lack predictability. OBJECTIVE: Compare the healing potential of late-stage ligature-induced periodontitis (PD) and peri-implantitis (PI) after ligature removal. METHODS: Four-week-old C57BL/6J male mice had their left maxillary molars extracted. After eight weeks, implants were placed in healed sockets and allowed to osseointegrate...
October 24, 2017: Journal of Oral Implantology
https://www.readbyqxmd.com/read/29044525/susceptibility-of-different-mouse-strains-to-peri-implantitis
#6
S Hiyari, A Naghibi, R Wong, R Sadreshkevary, L Yi-Ling, S Tetradis, P M Camargo, F Q Pirih
BACKGROUND AND OBJECTIVE: Peri-implantitis (PI) is an inflammatory condition that affects the tissues surrounding dental implants. Although the pathogenesis of PI is not fully understood, evidence suggests that the etiology is multifactorial and may include a genetic component. The aim of this study was to investigate the role of genetics in the development of peri-implantitis. MATERIAL AND METHODS: Four-week-old C57BL/6J, C3H/HeJ and A/J male mice had their left maxillary molars extracted...
October 17, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28954199/zoledronate-impairs-socket-healing-after-extraction-of-teeth-with-experimental-periodontitis
#7
A Soundia, D Hadaya, N Esfandi, I Gkouveris, R Christensen, S M Dry, O Bezouglaia, F Pirih, N Nikitakis, T Aghaloo, S Tetradis
Osteonecrosis of the jaws (ONJ) is a rare but severe complication of antiresorptive medications, such as bisphosphonates, used in the treatment of bone malignancy or osteoporosis. Tooth extraction and dental disease have been strongly associated with ONJ development. Here, we investigated molecular and cellular markers of socket healing after extraction of healthy or teeth with experimental periodontitis (EP) in Wistar-Han rats treated with zoledronic acid (ZA). We included 4 experimental groups: vehicle-treated animals with extraction of healthy teeth or teeth with ligature-induced EP and ZA-treated animals with extraction of healthy teeth or teeth with EP...
September 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28921659/ligature-induced-peri-implantitis-and-periodontitis-in-mice
#8
Sarah Hiyari, Ryan Wong, Aline Yaghsezian, Azadi Naghibi, Sotirios Tetradis, Paulo M Camargo, Flavia Q Pirih
AIM: Peri-implantitis (PI), inflammation around dental implants, shares characteristics with periodontitis (PD). However, PI is more difficult to control, treat, and detailed pathophysiology is unclear. We aimed to compare PI and PD progression utilizing a murine model. MATERIALS AND METHODS: Four-week-old male C57BL/6J mice had their left maxillary molars extracted. Implants were placed in healed extraction sockets and osseointegrated. Ligatures were tied around the implant and second molar...
September 16, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28094562/effects-of-bisphosphonate-administration-on-cleft-bone-graft-in-a-rat-model
#9
Nicole Cheng, Juyoung Park, Jeffrey Olson, Taewoo Kwon, Deborah Lee, Rachel Lim, Sandy Ha, Reuben Kim, Xinli Zhang, Kang Ting, Sotirios Tetradis, Christine Hong
OBJECTIVE:   Bone grafts in patients with cleft lip and palate can undergo a significant amount of resorption. The aim of this study was to investigate the effects of bisphosphonates (BPs) on the success of bone grafts in rats. DESIGN:   Thirty-five female 15-week-old Fischer F344 Inbred rats were divided into the following experimental groups, each receiving bone grafts to repair an intraoral CSD: (1) Graft/saline: systemic administration of saline and (2) systemic administration of zoledronic acid immediately following surgery (graft/BP/T0), (3) 1 week postoperatively (graft/BP/T1), and (4) 3 weeks postoperatively (graft/BP/T2)...
November 2017: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/27956123/case-based-review-of-osteonecrosis-of-the-jaw-onj-and-application-of-the-international-recommendations-for-management-from-the-international-task-force-on-onj
#10
REVIEW
Aliya A Khan, Archie Morrison, David L Kendler, Rene Rizzoli, David A Hanley, Dieter Felsenberg, Laurie K McCauley, Felice O'Ryan, Ian R Reid, Salvatore L Ruggiero, Akira Taguchi, Sotirios Tetradis, Nelson B Watts, Maria Luisa Brandi, Edmund Peters, Teresa Guise, Richard Eastell, Angela M Cheung, Suzanne N Morin, Basel Masri, Cyrus Cooper, Sarah L Morgan, Barbara Obermayer-Pietsch, Bente L Langdahl, Rana Al Dabagh, K Shawn Davison, George K Sándor, Robert G Josse, Mohit Bhandari, Mohamed El Rabbany, Dominique D Pierroz, Riad Sulimani, Deborah P Saunders, Jacques P Brown, Juliet Compston
Osteonecrosis of the jaw (ONJ) has been associated with antiresorptive therapy in both oncology and osteoporosis patients. This debilitating condition is very rare and advances in diagnosis and management may now effectively reduce the risk of its development and offer valuable treatment options for affected patients. This paper provides a case-based review of ONJ and application of the International Task Force on ONJ (referred to as the "Task Force") recommendations for the diagnosis and management of ONJ...
January 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/27569557/osteonecrosis-of-the-jaw-in-the-absence-of-antiresorptive-or-antiangiogenic-exposure-a-series-of-6-cases
#11
Tara L Aghaloo, Sotirios Tetradis
PURPOSE: Medication-related osteonecrosis of the jaws (MRONJ) is a well-described complication of antiresorptive and antiangiogenic medications. Although osteonecrosis can be associated with other inciting events and medications, such as trauma, infection, steroids, chemotherapy, and coagulation disorders, these are rarely reported in the literature. MATERIALS AND METHODS: This is a six case series of MRONJ associated with medications other than antiresorptive or antiangiogenic drugs...
January 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27354930/efficacy-of-intraperitoneal-administration-of-pegylated-nell-1-for-bone-formation
#12
Justine Tanjaya, Yulong Zhang, Soonchul Lee, Jiayu Shi, Eric Chen, Pia Ang, Xinli Zhang, Sotirios Tetradis, Kang Ting, Benjamin Wu, Chia Soo, Jin Hee Kwak
Systemically delivered NEL-like molecule-1 (NELL-1), a potent pro-osteogenic protein, promotes bone formation in healthy and osteoporotic mouse models. PEGylation of NELL-1 (NELL-PEG) increases the half-life of the protein in a mouse model without compromising its osteogenic potential, thereby improving its pharmacokinetics upon systemic delivery. This study consists of a twofold approach: a biodistribution test and an in vivo osteogenic potential test. The biodistribution test compared two commonly used administration methods for drug delivery other than intravenous-intraperitoneal (IP) and subcutaneous (SC)-to examine NELL-PEG biodistribution in mice...
2016: BioResearch Open Access
https://www.readbyqxmd.com/read/27327410/osteonecrosis-of-the-jaws-onj-in-mice-after-extraction-of-teeth-with-periradicular-disease
#13
Akrivoula Soundia, Danny Hadaya, Navid Esfandi, Rafael Scaf de Molon, Olga Bezouglaia, Sarah M Dry, Flavia Q Pirih, Tara Aghaloo, Sotirios Tetradis
Osteonecrosis of the jaws (ONJ) is a complication of antiresorptive medications, such as denosumab or bisphosphonates, prescribed to patients with bone malignancy or osteoporosis. The most common instigating local factor in ONJ pathogenesis is tooth extraction. However, in adults the great majority of teeth are extracted due to dental disease. Here, we have investigated alveolar bone healing after extraction of healthy teeth or teeth with naturally occurring periradicular disease in mice treated with high dose zoledronic acid (ZA), a potent bisphosphonate, or OPG-Fc, a RANKL inhibitor...
September 2016: Bone
https://www.readbyqxmd.com/read/26950411/rheumatoid-arthritis-exacerbates-the-severity-of-osteonecrosis-of-the-jaws-onj-in-mice-a-randomized-prospective-controlled-animal-study
#14
Rafael Scaf de Molon, Chingyun Hsu, Olga Bezouglaia, Sarah M Dry, Flavia Q Pirih, Akrivoula Soundia, Fernando Queiroz Cunha, Joni Augusto Cirelli, Tara L Aghaloo, Sotirios Tetradis
Rheumatoid arthritis (RA), an autoimmune inflammatory disorder, results in persistent synovitis with severe bone and cartilage destruction. Bisphosphonates (BPs) are often utilized in RA patients to reduce bone destruction and manage osteoporosis. However, BPs, especially at high doses, are associated with osteonecrosis of the jaw (ONJ). Here, utilizing previously published ONJ animal models, we are exploring interactions between RA and ONJ incidence and severity. DBA1/J mice were divided into four groups: control, zoledronic acid (ZA), collagen-induced arthritis (CIA), and CIA-ZA...
August 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/26906176/modeling-vitamin-d-insufficiency-and-moderate-deficiency-in-adult-mice-via-dietary-cholecalciferol-restriction
#15
Sanjay M Mallya, Kristin R Corrado, Elizabeth A Saria, Feng-Ning Frank Yuan, Huy Q Tran, Kirsten Saucier, Elisa Atti, Sotirios Tetradis, Andrew Arnold
PURPOSE: We sought to develop and characterize a model of human vitamin D nutritional insufficiency/deficiency in the adult mouse, which could have broad utility in examining health consequences of this common condition. METHODS: Adult mice were fed diets containing cholecalciferol contents of 0.05 IU/g, 0.25 IU/g, 0.5 IU/g or 1.5 IU/g for four months. We studied induction of steady-state vitamin D insufficiency, and its consequences on primary cholecalciferol metabolite levels, calcium homeostasis, parathyroid physiology, and bone morphology...
November 2016: Endocrine Research
https://www.readbyqxmd.com/read/26820006/trends-in-dentomaxillofacial-imaging
#16
Sanjay M Mallya, Sotirios Tetradis
No abstract text is available yet for this article.
September 2015: Journal of the California Dental Association
https://www.readbyqxmd.com/read/26772960/novel-wnt-regulator-nel-like-molecule-1-antagonizes-adipogenesis-and-augments-osteogenesis-induced-by-bone-morphogenetic-protein-2
#17
Jia Shen, Aaron W James, Xinli Zhang, Shen Pang, Janette N Zara, Greg Asatrian, Michael Chiang, Min Lee, Kevork Khadarian, Alan Nguyen, Kevin S Lee, Ronald K Siu, Sotirios Tetradis, Kang Ting, Chia Soo
The differentiation factor NEL-like molecule-1 (NELL-1) has been reported as osteoinductive in multiple in vivo preclinical models. Bone morphogenetic protein (BMP)-2 is used clinically for skeletal repair, but in vivo administration can induce abnormal, adipose-filled, poor-quality bone. We demonstrate that NELL-1 combined with BMP2 significantly optimizes osteogenesis in a rodent femoral segmental defect model by minimizing the formation of BMP2-induced adipose-filled cystlike bone. In vitro studies using the mouse bone marrow stromal cell line M2-10B4 and human primary bone marrow stromal cells have confirmed that NELL-1 enhances BMP2-induced osteogenesis and inhibits BMP2-induced adipogenesis...
February 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/26679333/osteonecrosis-of-the-jaw-an-update-for-dentists
#18
REVIEW
Archie Morrison, Aliya Khan, Sotirios Tetradis, Edmund Peters
No abstract text is available yet for this article.
2015: Journal—Canadian Dental Association, Journal de L'Association Dentaire Canadienne
https://www.readbyqxmd.com/read/26452304/nanodiamond-gutta-percha-composite-biomaterials-for-root-canal-therapy
#19
Dong-Keun Lee, Sue Vin Kim, Adelheid Nerisa Limansubroto, Albert Yen, Akrivoula Soundia, Cun-Yu Wang, Wenyuan Shi, Christine Hong, Sotirios Tetradis, Yong Kim, No-Hee Park, Mo K Kang, Dean Ho
Root canal therapy (RCT) represents a standard of treatment that addresses infected pulp tissue in teeth and protects against future infection. RCT involves removing dental pulp comprising blood vessels and nerve tissue, decontaminating residually infected tissue through biomechanical instrumentation, and root canal obturation using a filler material to replace the space that was previously composed of dental pulp. Gutta percha (GP) is typically used as the filler material, as it is malleable, inert, and biocompatible...
November 24, 2015: ACS Nano
https://www.readbyqxmd.com/read/26412796/pathophysiology-of-osteonecrosis-of-the-jaws
#20
REVIEW
Tara Aghaloo, Renna Hazboun, Sotirios Tetradis
Osteonecrosis of the jaw (ONJ) is a multifactorial disease in patients with primary or metastatic bone malignancy or osteoporosis undergoing systemic antiresorptive therapy, where pathophysiology has not yet been fully determined. The staging of ONJ is based on severity of symptoms and extent of clinical and radiographic findings. Treatment strategies range from conservative local wound care to aggressive resective surgery of all necrotic bone. The first ONJ cases were reported in 2003 and 2004, and although significant progress has been made in our understanding of the disease, much more work needs to be done to completely explain its pathophysiology...
November 2015: Oral and Maxillofacial Surgery Clinics of North America
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