keyword
MENU ▼
Read by QxMD icon Read
search

tetradis

keyword
https://www.readbyqxmd.com/read/27569557/osteonecrosis-of-the-jaw-in-the-absence-of-antiresorptive-or-antiangiogenic-exposure-a-series-of-6-cases
#1
Tara L Aghaloo, Sotirios Tetradis
Medication-related osteonecrosis of the jaws (MRONJ) is a well-described complication of antiresorptive and antiangiogenic medications. Although osteonecrosis can be associated with other inciting events and medications, such as trauma, infection, steroids, chemotherapy, and coagulation disorders, these are rarely reported in the literature. With the continued development and clinical use of new biologic medications for diseases such as cancer and rheumatoid arthritis, it is important to continue to evaluate their effects on the oral cavity...
July 30, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27354930/efficacy-of-intraperitoneal-administration-of-pegylated-nell-1-for-bone-formation
#2
Justine Tanjaya, Yulong Zhang, Soonchul Lee, Jiayu Shi, Eric Chen, Pia Ang, Xinli Zhang, Sotirios Tetradis, Kang Ting, Benjamin Wu, Chia Soo, Jin Hee Kwak
Systemically delivered NEL-like molecule-1 (NELL-1), a potent pro-osteogenic protein, promotes bone formation in healthy and osteoporotic mouse models. PEGylation of NELL-1 (NELL-PEG) increases the half-life of the protein in a mouse model without compromising its osteogenic potential, thereby improving its pharmacokinetics upon systemic delivery. This study consists of a twofold approach: a biodistribution test and an in vivo osteogenic potential test. The biodistribution test compared two commonly used administration methods for drug delivery other than intravenous-intraperitoneal (IP) and subcutaneous (SC)-to examine NELL-PEG biodistribution in mice...
2016: BioResearch Open Access
https://www.readbyqxmd.com/read/27327410/osteonecrosis-of-the-jaws-onj-in-mice-after-extraction-of-teeth-with-periradicular-disease
#3
Akrivoula Soundia, Danny Hadaya, Navid Esfandi, Rafael Scaf de Molon, Olga Bezouglaia, Sarah M Dry, Flavia Q Pirih, Tara Aghaloo, Sotirios Tetradis
Osteonecrosis of the jaws (ONJ) is a complication of antiresorptive medications, such as denosumab or bisphosphonates, prescribed to patients with bone malignancy or osteoporosis. The most common instigating local factor in ONJ pathogenesis is tooth extraction. However, in adults the great majority of teeth are extracted due to dental disease. Here, we have investigated alveolar bone healing after extraction of healthy teeth or teeth with naturally occurring periradicular disease in mice treated with high dose zoledronic acid (ZA), a potent bisphosphonate, or OPG-Fc, a RANKL inhibitor...
September 2016: Bone
https://www.readbyqxmd.com/read/26950411/rheumatoid-arthritis-exacerbates-the-severity-of-osteonecrosis-of-the-jaws-onj-in-mice-a-randomized-prospective-controlled-animal-study
#4
Rafael Scaf de Molon, Chingyun Hsu, Olga Bezouglaia, Sarah M Dry, Flavia Q Pirih, Akrivoula Soundia, Fernando Queiroz Cunha, Joni Augusto Cirelli, Tara L Aghaloo, Sotirios Tetradis
Rheumatoid arthritis (RA), an autoimmune inflammatory disorder, results in persistent synovitis with severe bone and cartilage destruction. Bisphosphonates (BPs) are often utilized in RA patients to reduce bone destruction and manage osteoporosis. However, BPs, especially at high doses, are associated with osteonecrosis of the jaw (ONJ). Here, utilizing previously published ONJ animal models, we are exploring interactions between RA and ONJ incidence and severity. DBA1/J mice were divided into four groups: control, zoledronic acid (ZA), collagen-induced arthritis (CIA), and CIA-ZA...
August 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/26906176/modeling-vitamin-d-insufficiency-and-moderate-deficiency-in-adult-mice-via-dietary-cholecalciferol-restriction
#5
Sanjay M Mallya, Kristin R Corrado, Elizabeth A Saria, Feng-Ning Frank Yuan, Huy Q Tran, Kirsten Saucier, Elisa Atti, Sotirios Tetradis, Andrew Arnold
PURPOSE: We sought to develop and characterize a model of human vitamin D nutritional insufficiency/deficiency in the adult mouse, which could have broad utility in examining health consequences of this common condition. METHODS: Adult mice were fed diets containing cholecalciferol contents of 0.05 IU/g, 0.25 IU/g, 0.5 IU/g or 1.5 IU/g for four months. We studied induction of steady-state vitamin D insufficiency, and its consequences on primary cholecalciferol metabolite levels, calcium homeostasis, parathyroid physiology, and bone morphology...
November 2016: Endocrine Research
https://www.readbyqxmd.com/read/26820006/trends-in-dentomaxillofacial-imaging
#6
Sanjay M Mallya, Sotirios Tetradis
No abstract text is available yet for this article.
September 2015: Journal of the California Dental Association
https://www.readbyqxmd.com/read/26772960/novel-wnt-regulator-nel-like-molecule-1-antagonizes-adipogenesis-and-augments-osteogenesis-induced-by-bone-morphogenetic-protein-2
#7
Jia Shen, Aaron W James, Xinli Zhang, Shen Pang, Janette N Zara, Greg Asatrian, Michael Chiang, Min Lee, Kevork Khadarian, Alan Nguyen, Kevin S Lee, Ronald K Siu, Sotirios Tetradis, Kang Ting, Chia Soo
The differentiation factor NEL-like molecule-1 (NELL-1) has been reported as osteoinductive in multiple in vivo preclinical models. Bone morphogenetic protein (BMP)-2 is used clinically for skeletal repair, but in vivo administration can induce abnormal, adipose-filled, poor-quality bone. We demonstrate that NELL-1 combined with BMP2 significantly optimizes osteogenesis in a rodent femoral segmental defect model by minimizing the formation of BMP2-induced adipose-filled cystlike bone. In vitro studies using the mouse bone marrow stromal cell line M2-10B4 and human primary bone marrow stromal cells have confirmed that NELL-1 enhances BMP2-induced osteogenesis and inhibits BMP2-induced adipogenesis...
February 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/26679333/osteonecrosis-of-the-jaw-an-update-for-dentists
#8
Archie Morrison, Aliya Khan, Sotirios Tetradis, Edmund Peters
No abstract text is available yet for this article.
2015: Journal—Canadian Dental Association, Journal de L'Association Dentaire Canadienne
https://www.readbyqxmd.com/read/26452304/nanodiamond-gutta-percha-composite-biomaterials-for-root-canal-therapy
#9
Dong-Keun Lee, Sue Vin Kim, Adelheid Nerisa Limansubroto, Albert Yen, Akrivoula Soundia, Cun-Yu Wang, Wenyuan Shi, Christine Hong, Sotirios Tetradis, Yong Kim, No-Hee Park, Mo K Kang, Dean Ho
Root canal therapy (RCT) represents a standard of treatment that addresses infected pulp tissue in teeth and protects against future infection. RCT involves removing dental pulp comprising blood vessels and nerve tissue, decontaminating residually infected tissue through biomechanical instrumentation, and root canal obturation using a filler material to replace the space that was previously composed of dental pulp. Gutta percha (GP) is typically used as the filler material, as it is malleable, inert, and biocompatible...
November 24, 2015: ACS Nano
https://www.readbyqxmd.com/read/26412796/pathophysiology-of-osteonecrosis-of-the-jaws
#10
REVIEW
Tara Aghaloo, Renna Hazboun, Sotirios Tetradis
Osteonecrosis of the jaw (ONJ) is a multifactorial disease in patients with primary or metastatic bone malignancy or osteoporosis undergoing systemic antiresorptive therapy, where pathophysiology has not yet been fully determined. The staging of ONJ is based on severity of symptoms and extent of clinical and radiographic findings. Treatment strategies range from conservative local wound care to aggressive resective surgery of all necrotic bone. The first ONJ cases were reported in 2003 and 2004, and although significant progress has been made in our understanding of the disease, much more work needs to be done to completely explain its pathophysiology...
November 2015: Oral and Maxillofacial Surgery Clinics of North America
https://www.readbyqxmd.com/read/26411857/long-term-evaluation-of-oral-gavage-with-periodontopathogens-or-ligature-induction-of-experimental-periodontal-disease-in-mice
#11
Rafael Scaf de Molon, Vinicius Ibiapina Mascarenhas, Erica Dorigatti de Avila, Livia Sertori Finoti, Gustavo Boze Toffoli, Denise Madalena Palomari Spolidorio, Raquel Mantuaneli Scarel-Caminaga, Sotirios Tetradis, Joni Augusto Cirelli
OBJECTIVE: To evaluate in long-term periods the destruction of periodontal tissues and bacterial colonization induced by oral gavage with periodontopathogens or ligature experimental periodontal disease models. MATERIAL AND METHODS: Forty-eight C57BL/6 J mice were divided into four groups: group C: negative control; group L: ligature; group G-Pg: oral gavage with Porphyromonas gingivalis; and group G-PgFn: oral gavage with Porphyromonas gingivalis associated with Fusobacterium nucleatum...
July 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/26390978/response-to-comments-on-diagnosis-and-management-of-osteoporosis-of-the-jaw-a-systematic-review-and-international-consensus
#12
Aliya Khan, Archie Morrison, Salvatore Ruggiero, Sotirios Tetradis, K Shawn Davison, Edward Peters
No abstract text is available yet for this article.
October 2015: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/26133934/quantitative-analysis-of-3-dimensional-facial-soft-tissue-photographic-images-technical-methods-and-clinical-application
#13
Vikrum Nanda, Boris Gutman, Ehab Bar, Suha Alghamdi, Sotirios Tetradis, Aldons J Lusis, Eleazar Eskin, Won Moon
BACKGROUND: The recent advent of 3D photography has created the potential for comprehensive facial evaluation. However, lack of practical true 3D analysis of the information collected from 3D images has been the factor limiting widespread utilization in orthodontics. Current evaluation of 3D facial soft tissue images relies on subjective visual evaluation and 2D distances to assess facial disharmony. The objectives of this project strive to map the surface and define boundaries of 3D facial soft tissue, modify mathematical functions to average multiple 3D facial images, and mathematically average 3D facial images allowing generation of color-coded surface deviation relative to a true average...
2015: Progress in Orthodontics
https://www.readbyqxmd.com/read/26103496/evaluation-of-the-scatter-doses-in-the-direction-of-the-buccal-mucosa-from-dental-metals
#14
COMPARATIVE STUDY
Hiroaki Shimamoto, Iori Sumida, Naoya Kakimoto, Keisuke Marutani, Ryoko Okahata, Ai Usami, Tomomi Tsujimoto, Shumei Murakami, Souhei Furukawa, Sotirios Tetradis
The presence of dental metals creates radiation dose perturbation due to scattered radiation during radiation therapy for the head and neck region. The purpose of our study was to compare the scatter doses resulting from various dental metals in the direction of the buccal mucosa among a single-field technique, three-dimensional conformal radiation therapy (3D CRT), and intensity-modulated radiation therapy (IMRT) during radiation therapy for the head and neck region. We used nine metal cubes with 10 mm sides, which were placed inside a water phantom...
2015: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/26037327/reconstruction-of-the-alveolar-buccal-bone-plate-in-compromised-fresh-socket-after-immediate-implant-placement-followed-by-immediate-provisionalization
#15
Rafael Scaf de Molon, Erica Dorigatti de Avila, Luiz Antonio Borelli de Barros-Filho, Weber Adad Ricci, Sotirios Tetradis, Joni Augusto Cirelli, Luiz Antonio Borelli de Barros
OBJECTIVE: The aim of this clinical report was to reestablish the buccal bone wall after immediate implant placement. The socket defect was corrected with autogenous bone, and a connective tissue graft was removed from the maxillary tuberosity to increase the thickness, height, and width of the buccal bone and gingival tissue followed by immediate provisionalization of the crown during the same operation. CLINICAL CONSIDERATIONS: A 66-year-old patient presented with a hopeless maxillary left central incisor with loss of the buccal bone wall...
May 2015: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/26017711/trigeminal-neuralgia-and-facial-pain-imaging
#16
REVIEW
Steven Graff-Radford, Rachael Gordon, John Ganal, Sotirois Tetradis
The trigeminal nerve or fifth cranial nerve has an extensive distribution in the head and face. It is the source for pain conduction and thereby is often implicated in a variety of disorders including inflammatory and neoplastic diseases. To determine the disease source, understanding the trigeminal nerve anatomy is essential, and further being able to image the trigeminal nerve provides insight into the location and type of pathology. The best approach to imaging is to consider the nerve in segments. The nerve segments may be divided into the brainstem, cisternal, Meckel's cave, cavernous sinus, and peripheral divisions...
June 2015: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/25939409/response-to-comments-on-diagnosis-and-management-of-osteoporosis-of-the-jaw-a-systematic-review-and-international-consensus
#17
COMMENT
Aliya Khan, Archie Morrison, Salvatore Ruggiero, Sotirios Tetradis, K Shawn Davison, Edward Peters, Juliet Compston
No abstract text is available yet for this article.
June 2015: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/25793794/accelerating-cosmological-expansion-from-shear-and-bulk-viscosity
#18
Stefan Floerchinger, Nikolaos Tetradis, Urs Achim Wiedemann
The dissipation of energy from local velocity perturbations in the cosmological fluid affects the time evolution of spatially averaged fluid dynamic fields and the cosmological solution of Einstein's field equations. We show how this backreaction effect depends on shear and bulk viscosity and other material properties of the dark sector, as well as the spectrum of perturbations. If sufficiently large, this effect could account for the acceleration of the cosmological expansion.
March 6, 2015: Physical Review Letters
https://www.readbyqxmd.com/read/25727550/opg-fc-but-not-zoledronic-acid-discontinuation-reverses-osteonecrosis-of-the-jaws-onj-in-mice
#19
Rafael Scaf de Molon, Hiroaki Shimamoto, Olga Bezouglaia, Flavia Q Pirih, Sarah M Dry, Paul Kostenuik, Rogely W Boyce, Denise Dwyer, Tara L Aghaloo, Sotirios Tetradis
Osteonecrosis of the jaws (ONJ) is a significant complication of antiresorptive medications, such as bisphosphonates and denosumab. Antiresorptive discontinuation to promote healing of ONJ lesions remains highly controversial and understudied. Here, we investigated whether antiresorptive discontinuation alters ONJ features in mice, employing the potent bisphosphonate zoledronic acid (ZA) or the receptor activator of NF-κB ligand (RANKL) inhibitor OPG-Fc, utilizing previously published ONJ animal models. Mice were treated with vehicle (veh), ZA, or OPG-Fc for 11 weeks to induce ONJ, and antiresorptives were discontinued for 6 or 10 weeks...
September 2015: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/25581386/heritability-of-periodontal-bone-loss-in-mice
#20
S Hiyari, E Atti, P M Camargo, E Eskin, A J Lusis, S Tetradis, F Q Pirih
BACKGROUND: Periodontitis is an inflammatory disease of the periodontal tissues that compromises tooth support and can lead to tooth loss. Although bacterial biofilm is central in disease pathogenesis, the host response plays an important role in the progression and severity of periodontitis. Indeed, clinical genetic studies indicate that periodontitis is 50% heritable. In this study, we hypothesized that lipopolysaccharide (LPS) injections lead to a strain-dependent periodontal bone loss pattern...
December 2015: Journal of Periodontal Research
keyword
keyword
115131
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"