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Seborrheic keratosis

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https://www.readbyqxmd.com/read/29665030/dermatologic-toxicity-from-novel-therapy-using-antimicrobial-peptide-ll-37-in-melanoma-a-detailed-examination-of-the-clinicopathologic-features
#1
Tsetan Dolkar, Celestine M Trinidad, Kelly C Nelson, Rodabe N Amaria, Priyadharsini Nagarajan, Carlos A Torres-Cabala, Doina Ivan, Victor G Prieto, Michael T Tetzlaff, Jonathan L Curry, Phyu P Aung
LL-37 is a naturally occurring 37-amino acid that is part of innate immunity in human skin. Preclinical studies have demonstrated that intra-tumoral injections of LL-37 stimulate the innate immune system by activation of plasmacytoid dendritic cells, which mediate tumor destruction. LL-37 intra-tumoral injections have been utilized in a Phase 1 clinical trial for melanoma patients with cutaneous metastases. We report dermatologic toxicity in a 63-year-old woman with stage IIIC melanoma of the right calf and inguinal lymph nodes...
April 17, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29601933/an-ex-vivo-evaluation-of-cytotoxicity-and-melanocyte-viability-after-a-101-hydrogen-peroxide-topical-solution-40-or-cryosurgery-treatment-in-seborrheic-keratosis-lesions
#2
Stephanie Kao, Alexi Kiss, Tatiana Efimova, Adam Friedman
No abstract text is available yet for this article.
March 27, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29569258/primary-cutaneous-ganglioneuroma-anatomoclinical-study-of-4-cases-with-focus-on-merkel-cells
#3
David Romero-Pérez, Marie-Hélène Jegou, Claire Lecointre, Isabelle Penchet, Bernard Cribier
Cutaneous ganglioneuromas (CGN) are exceptional. We aim to describe the anatomoclinical profile of primary CGN and report 4 cases. Patients were 2 men and 2 women aged 53-to-76-years-old, who had flesh-colored nodules on the back, associated with adjacent keratotic changes, i.e. epidermal nevus (1 case) or seborrheic keratosis (3 cases). Histopathology showed ganglion cells within a proliferation of Schwann cells. The epidermis was acanthotic, associated with sebaceous induction in 2 cases, and with follicular hyperplasia as in fibroepithelial tumors (1 case), or with tricholemmoma (2 cases)...
March 22, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29567894/merkel-cell-carcinoma-with-seborrheic-keratosis-a-unique-association
#4
Murthy S Anand, Shantha Krishnamurthy, Suvarna Ravindranath, Jyothi Ranganathan
Merkel cell carcinoma (MCC) is a rare, clinically aggressive neuroendocrine carcinoma of the skin; MCC is 40 times less common as compared to melanoma. The most frequently reported sites have been the head and neck, extremities, and trunk. Potential mimics include malignant melanoma, lymphoma, or metastatic small cell (neuroendocrine) carcinomas. Histopathology of MCC resembles small cell carcinoma both morphologically and on IHC. The possible cell of origin was proposed as the Merkel cell, which functions as a mechanoreceptor...
January 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29566932/the-status-of-the-seborrheic-keratosis
#5
Ayse Serap Karadag, Lawrence Charles Parish
Seborrheic keratosis (SK), whose appearance is generally a small roundish reddish to brownish scaling lesion ranging in size from a few mm to many mm, may have a single presentation or be one of many such lesions. Because it is a commonly encountered lesion on the face, trunk, or extemities and is readily recognized clinically, it is infrequently biopsied. When the lesion has an unusual pattern or has become irritated, it may rarely mimic a malignancy,Most patients ignore such common age spots; however, others may have concern about their appearence, in which case the SKs have been surgicaly excised...
March 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29566370/dermoscopic-features-of-basal-cell-carcinoma-on-the-lower-limbs-a-chameleon
#6
Mara Lombardi, Riccardo Pampena, Stefania Borsari, Caterina Bombonato, Elisa Benati, Giovanni Pellacani, Caterina Longo
BACKGROUND: Lower limbs represent an uncommon location for basal cell carcinoma (BCC) and only few reports have described dermoscopic features of BCC in this body site. Since BCCs of the lower limbs frequently display nonclassic BCC dermoscopic criteria, they can simulate other benign or malignant lesions. OBJECTIVE: Our aim was to describe the dermoscopic features of BCC located on lower limbs and to define which criteria were more associated with their benign- or malignant-looking appearance...
March 22, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29513830/american-cutaneous-leishmaniasis-triggered-by-electrocoagulation
#7
Sofia Sales Martins, Adriana de Oliveira Santos, Beatriz Dolabela Lima, Ciro Martins Gomes, Raimunda Nonata Ribeiro Sampaio
Cutaneous leishmaniasis is usually transmitted by infected phlebotomine sand fly bites that initiate local cutaneous lesions. Few reports in the literature describe other modes of transmission. We report a case of a previously healthy 59-year-old woman who underwent electrocoagulation to remove seborrheic keratosis confirmed by dermatoscopy. Three months later, a skin fragment tested positive for Leishmania culture; the parasite was identified as L. (V.) braziliensis. Trauma may generate inflammatory cascades that favor Leishmania growth and lesion formation in previously infected patients...
January 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29502116/dermoscopy-improves-the-diagnostic-accuracy-of-melanomas-clinically-resembling-seborrheic-keratosis-cross-sectional-study-of-the-ability-to-detect-seborrheic-keratosis-like-melanomas-by-a-group-of-dermatologists-with-varying-degrees-of-experience
#8
Cristina Carrera, Sonia Segura, Paula Aguilera, Carol Midori Takigami, Antonio Gomes, Alicia Barreiro, Massimiliano Scalvenzi, Caterina Longo, Stefano Cavicchini, Luc Thomas, Josep Malvehy, Susana Puig, Iris Zalaudek
BACKGROUND: Malignant melanomas mimicking seborrheic keratosis (SK-like MMs) carry the risk of delayed diagnosis and inadequate treatment. The value of dermoscopy to improve the correct detection of these mimickers has not been previously studied. OBJECTIVE: To evaluate the diagnostic accuracy of clinically SK-like MMs with and without dermoscopy. METHODS: Clinical and dermoscopic images of histopathologically proven SK-like MMs (n = 134) intermingled with other melanomas and benign tumors were randomly presented to clinicians with different levels of experience, blinded to the diagnosis and goal of the study...
March 2, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29485577/routine-pathologic-evaluation-of-plastic-surgery-specimens-are-we-wasting-time-and-money
#9
Mark Fisher, Brandon Alba, Tawfiqul Bhuiya, Armen K Kasabian, Charles H Thorne, Neil Tanna
BACKGROUND: Recent health care changes have encouraged efforts to decrease costs. In plastic surgery, an area of potential cost savings includes appropriate use of pathologic examination. Specimens are frequently sent because of hospital policy, insurance request, or habit, even when clinically unnecessary. This is an area where evidence-based guidelines are lacking and significant cost-savings can be achieved. METHODS: All specimen submitted for pathologic examination at two hospitals between January and December of 2015 were queried for tissue expanders, breast implants, fat, skin, abdominal pannus, implant capsule, hardware, rib, bone, cartilage, scar, and keloid...
March 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29485181/two-cases-of-seborrheic-keratosis-of-the-external-ear-canal-involvement-of-pik3ca-and-fgfr3-genes
#10
Marie De Loof, Jo Van Dorpe, Joni Van Der Meulen, Steve Lefever, Ingeborg Dhooge
BACKGROUND: Seborrheic keratosis (SK) of the outer ear canal is rarely described in literature. Etiological risk factors involved in SK such as exposure to human papillomavirus (HPV) and ultraviolet (UV) light are established but must still be confirmed. In recent years, new insights into the pathogenesis of SKs occurred in the area of molecular pathogenesis. Fibroblast growth factor receptor 3 (FGFR3) gene and p110α subunit of phosphoinositide 3-kinase (PIK3CA) oncogene mutations are known to be involved...
February 27, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29483985/advanced-pretibial-melanoma-apm-clinicians-behaviour-as-triggering-factor
#11
Georgi Tchernev, Ivan Pidakev, Anastasiya Atanasova Chokoeva, Uwe Wollina, Torello Lotti, Georgi Konstantinov Maximov, Ilia Lozev
BACKGROUND: Pigmented lesions represent a broad spectrum of clinical conditions, both benign and malignant. The precise diagnosis is often a challenge, while the clinical diagnostic criteria could be misleading, as a result of the frequently atypical presentation of otherwise completely benign in nature lesions. The variety of therapeutic options for benign pigmented lesions including shave curettage, local laser destruction, electrocoagulation removal could sound enticingly both for the physician and patient, but they destroy the possibility for histological examination and provide a deceptively feeling of calm, that the problem is solved...
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29436004/homeobox-transcriptional-factor-engrailed-homeobox-1-is-specifically-expressed-in-normal-and-neoplastic-sweat-gland-cells
#12
Keiko Miura, Takumi Akashi, Noboru Ando, Shinya Ayabe, Kou Kayamori, Takeshi Namiki, Yoshinobu Eishi
AIM: A number of homeobox transcriptional factors are utilized as organ-specific markers in the histopathological diagnosis of neoplasms. We have screened a homeobox gene that is specifically expressed in normal sweat gland cells and is useful for the histopathological diagnosis of sweat gland neoplasms. METHODS AND RESULTS: By screening an open database resource of The Human Protein Atlas, 37 genes among the 235 homeobox transcriptional factors were found to be specifically expressed in the skin...
February 12, 2018: Histopathology
https://www.readbyqxmd.com/read/29428356/classification-of-the-clinical-images-for-benign-and-malignant-cutaneous-tumors-using-a-deep-learning-algorithm
#13
Seung Seog Han, Myoung Shin Kim, Woohyung Lim, Gyeong Hun Park, Ilwoo Park, Sung Eun Chang
We tested the use of a deep learning algorithm to classify the clinical images of 12 skin diseases-basal cell carcinoma, squamous cell carcinoma, intraepithelial carcinoma, actinic keratosis, seborrheic keratosis, malignant melanoma, melanocytic nevus, lentigo, pyogenic granuloma, hemangioma, dermatofibroma, and wart. The convolutional neural network (Microsoft ResNet-152 model; Microsoft Research Asia, Beijing, China) was fine-tuned with images from the training portion of the Asan dataset, MED-NODE dataset, and atlas site images (19,398 images in total)...
February 8, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29423841/treatment-of-flat-and-elevated-pigmented-disorders-with-a-755-nm-alexandrite-picosecond-laser-clinical-and-histological-evaluation
#14
Adrian Alegre-Sanchez, Natalia Jiménez-Gómez, Óscar M Moreno-Arrones, Pablo Fonda-Pascual, Bibiana Pérez-García, Pedro Jaén-Olasolo, Pablo Boixeda
The novel picosecond lasers, initially developed for faster tattoo removal, have also shown great efficacy in endogenous pigmentary disorders. To describe the efficacy and safety profile of an alexandrite (755-nm) picosecond laser in a wide range of pigmented flat and elevated cutaneous lesions. A retrospective study was performed in which we collected all the clinical images of patients treated with the 755-nm alexandrite picosecond laser for 12 months (November 2016-November 2017). Clinical features were obtained from their medical charts...
February 9, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29418015/inverted-follicular-keratoses-of-the-buttocks
#15
Marie Kenney, Elizabeth B Lester, Deborah L Cook
No abstract text is available yet for this article.
February 8, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29340950/dermatologic-lesions-submitted-to-an-oral-and-maxillofacial-pathology-biopsy-service-an-analysis-of-2487-cases
#16
Rekha Reddy, Liya Davidova, Indraneel Bhattacharyya, Donald M Cohen, Mohammed N Islam, Sarah G Fitzpatrick
Skin lesions are often submitted to oral and maxillofacial pathology practices. The purpose of this study is to evaluate the frequency, distribution, variability, and composition of dermatologic lesions within a large oral and maxillofacial pathology biopsy service. An IRB-approved retrospective search of skin lesions diagnosed at University of Florida oral and maxillofacial pathology biopsy service between 1994 and 2015 was performed. 2487 cases were included in the study. Gender was reported in 2466 cases, of which 59% were male and 41% female...
January 16, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29314288/the-limitations-of-dermoscopy-false-positive-and-false-negative-tumours
#17
REVIEW
V Papageorgiou, Z Apalla, E Sotiriou, C Papageorgiou, E Lazaridou, S Vakirlis, D Ioannides, A Lallas
Dermoscopy has been documented to increase the diagnostic accuracy of clinicians evaluating skin tumours, improving their ability to detect skin cancer and better recognize benign moles. However, dermoscopically 'false-positive' and 'false-negative' tumours do exist. False-positive diagnosis usually leads to unnecessary excisions. False-negative diagnosis is much more dangerous, as it might result in overlooking a cancer, with severe undesirable consequences for the patient and the physician. Therefore, management strategies should mainly focus on addressing the risk of dermoscopically false-negative tumours...
January 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29230351/collision-skin-lesions-results-of-a-multicenter-study-of-the-international-dermoscopy-society-ids
#18
Andreas Blum, Graeme Siggs, Ashfaq A Marghoob, Jürgen Kreusch, Horacio Cabo, Gabriella Campos-do-Carmo, Ana Flávia Cavalcanti Shiraishi, Alexander Kienitz, Cayetana Maldonado-Seral, Paola Maltagliati-Holzner, Zeljko P Mijuskovic, Andrea M Yoshimura, Elvira Moscarella, Harold S Rabinovitz, Cristina Rodriguez-Garcia, Sonia Rodríguez Saa, Pietro Rubegni, Francesco Savoia, Olga Simionescu, Pedro Zaballos Diego, Rainer Hofmann-Wellenhof
Background: Collision lesions as two independent and unrelated skin tumors often manifest an atypical morphology. Objective: To determine the combinations of collision skin lesions (CSLs). Methods: Twenty-one pigmented lesion clinics in nine countries included 77 histopathologically proven CSLs in this retrospective observational study. Results: Seventy-seven CSLs from 75 patients (median age 59.8 years) were analyzed; 24...
October 2017: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29168986/skin-aging-parameters-a-window-to-heart-block
#19
Hisham Samir Roshdy, Mohammad Hassan Soliman, Ibtesam Ibrahim El-Dosouky, Soheir Ghonemy
BACKGROUND: Skin acts as a mirror to the internal state of the body. HYPOTHESIS: We tried to find the relation between skin aging parameters and the incidence of degenerative AV block. METHODS: This study included 97 patients divided into 2 groups; group D comprised 49 patients with advanced-degree AV block, and group C comprised the 48 matched control group. All were subjected to full history taking, thorough clinical examination, calculation of intrinsic skin aging score, and resting 12-lead surface electrocardiography (ECG)...
November 23, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/29141054/managing-seborrheic-keratoses-evolving-strategies-for-optimizing-patient-outcomes
#20
Geraldine Cheyana Ranasinghe, Adam J Friedman
<p>The seborrheic keratosis is the most common benign skin tumor of middle-aged and elderly adults, affecting nearly 83 million individuals in the US alone. Although these are benign lesions, many patients still undergo some form of treatment. Clinicians are frequently presented with a challenge when determining whether to remove a seborrheic keratosis, and which treatment modality to use when doing so. The most commonly used method of removal is cryotherapy, however there are numerous other options that can be employed with varying degrees of efficacy...
November 1, 2017: Journal of Drugs in Dermatology: JDD
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