Alina Maria Vîlcea, Loredana Elena Stoica, Bianca Cătălina Andreiana, Cecil Sorin Mirea, Tiberiu Ştefăniţă Ţenea Cojan, Ioana Cristina Vîlcea, Claudiu Mărgăritescu
Cutaneous squamous cell carcinoma (CSCC) is the second most common type of skin cancer, after basal cell carcinoma, representing about 10-20% of all malignant skin tumors. The mortality rates of CSCC approach those of renal and oropharyngeal carcinomas, as well as melanoma, with the increasing of the risk once metastases and perineural invasion occur. Both actinic keratosis (AK) and Bowen's disease (BD) are direct precursors with the potential for progression to CSCC. In this study, we analyzed the expression of Ki67, P16 and Beta-catenin in the precursor lesions of CSCC in relation to histological prognostic parameters, respectively between them, with the aim of identifying possible correlations with a role in prognosis...
2024: Romanian Journal of Morphology and Embryology