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"L-arginine"

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https://www.readbyqxmd.com/read/28813479/metabolomic-profiling-of-amines-in-sepsis-predicts-changes-in-nos-canonical-pathways
#1
Abel Tesfai, Niall MacCallum, Nicholas S Kirkby, Hime Gashaw, Nicola Gray, Elizabeth Want, Gregory J Quinlan, Sharon Mumby, James M Leiper, Mark Paul-Clark, Blerina Ahmetaj-Shala, Jane A Mitchell
RATIONALE: Nitric oxide synthase (NOS) is a biomarker/target in sepsis. NOS activity is driven by amino acids, which cycle to regulate the substrate L-arginine in parallel with cycles which regulate the endogenous inhibitors ADMA and L-NMMA. The relationship between amines and the consequence of plasma changes on iNOS activity in early sepsis is not known. OBJECTIVE: Our objective was to apply a metabolomics approach to determine the influence of sepsis on a full array of amines and what consequence these changes may have on predicted iNOS activity...
2017: PloS One
https://www.readbyqxmd.com/read/28812766/modulatory-effects-of-arginine-glutamine-and-branched-chain-amino-acids-on-heat-shock-proteins-immunity-and-antioxidant-response-in-exercised-rats
#2
Carolina Soares Moura, Pablo Christiano Barboza Lollo, Priscila Neder Morato, Eder Muller Risso, Jaime Amaya-Farfan
Heat shock proteins (HSPs) are endogenous proteins whose function is to maintain the cell's tolerance to insult, and glutamine supplementation is known to increase HSP expression during intense exercise. Since few studies have addressed the possibility that supplementation with other amino acids could have similar effects to that of glutamine, our objective was to evaluate the effects of leucine, valine, isoleucine and arginine as potential stimulators of HSPs 25, 60, 70 and 90 in rats subjected to acute exercise as a stressing factor...
August 16, 2017: Food & Function
https://www.readbyqxmd.com/read/28811749/acute-cocoa-flavanols-intake-has-minimal-effects-on-exercise-induced-oxidative-stress-and-nitric-oxide-production-in-healthy-cyclists-a-randomized-controlled-trial
#3
Lieselot Decroix, Cajsa Tonoli, Danusa Dias Soares, Amandine Descat, Marie-José Drittij-Reijnders, Antje R Weseler, Aalt Bast, Wilhelm Stahl, Elsa Heyman, Romain Meeusen
BACKGROUND: Cocoa flavanols (CF) can stimulate vasodilation by improved nitric oxide (NO) synthesis and have antioxidant and anti-inflammatory capacities. This study aimed to examine whether acute CF intake can affect exercise-induced changes in antioxidant capacity, oxidative stress, inflammation and NO production, as well as exercise performance and recovery in well-trained cyclists. METHODS: Twelve well-trained male cyclists (mean ± SD age, VO2max: 30 ± 3 years, 63...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28809932/rem-sleep-deprivation-induces-endothelial-dysfunction-and-hypertension-in-middle-aged-rats-roles-of-the-enos-no-cgmp-pathway-and-supplementation-with-l-arginine
#4
Jiaye Jiang, Zhongyuan Gan, Yuan Li, Wenqi Zhao, Hanqing Li, Jian-Pu Zheng, Yan Ke
Sleep loss can induce or aggravate the development of cardiovascular and cerebrovascular diseases. However, the molecular mechanism underlying this phenomenon is poorly understood. The present study was designed to investigate the effects of REM sleep deprivation on blood pressure in rats and the underlying mechanisms of these effects. After Sprague-Dawley rats were subjected to REM sleep deprivation for 5 days, their blood pressures and endothelial function were measured. In addition, one group of rats was given continuous access to L-arginine supplementation (2% in distilled water) for the 5 days before and the 5 days of REM sleep deprivation to reverse sleep deprivation-induced pathological changes...
2017: PloS One
https://www.readbyqxmd.com/read/28809782/dietary-supplementation-of-honey-bee-larvae-with-arginine-and-abscisic-acid-enhances-nitric-oxide-and-granulocyte-immune-responses-after-trauma
#5
Pedro Negri, Leonor Ramirez, Silvina Quintana, Nicolás Szawarski, Matías Maggi, Yves Le Conte, Lorenzo Lamattina, Martin Eguaras
Many biotic and abiotic stressors impact bees' health, acting as immunosupressors and contribute to colony losses. Thus, the importance of studying the immune response of honey bees is central to develop new strategies aiming to enhance bees' fitness to confront the threats affecting them. If a pathogen breaches the physical and chemical barriers, honey bees can protect themselves from infection with cellular and humoral immune responses which represent a second line of defense. Through a series of correlative studies we have previously reported that abscisic acid (ABA) and nitric oxide (NO) share roles in the same immune defenses of Apis mellifera (A...
August 15, 2017: Insects
https://www.readbyqxmd.com/read/28803324/decreased-serum-l-arginine-and-l-citrulline-levels-in-major-depression
#6
S Hess, G Baker, G Gyenes, R Tsuyuki, S Newman, Jean-Michel Le Melledo
RATIONALE: It has been suggested that endothelial dysfunction caused by a decreased endothelial production of nitric oxide (NO) may contribute to the consistently observed increased risk of developing cardiovascular disease (CVD) in physically healthy patients suffering from major depression (MD). NO is a gas synthesized from Larginine (a conditionally essential amino acid) and oxygen by endothelial nitric oxide synthase (eNOS). The end products of NO production include both NO and L-citrulline...
August 13, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28799895/arginine-and-aerobic-training-prevent-endothelial-and-metabolic-alterations-in-rats-at-high-risk-for-the-development-of-the-metabolic-syndrome
#7
Renata F Medeiros, Thaiane G Gaique, Thais Bento-Bernardes, Raquel Kindlovits, Tamiris M B Gomes, Nadia Alice V Motta, Fernanda Carla Brito, Caroline Fernandes-Santos, Karen J Oliveira, Antonio Claudio L Nóbrega
Endothelial function is a key mechanism in the development of CVD. Arginine and exercise are important non-pharmacological strategies for mitigating the impact of metabolic changes in the metabolic syndrome, but the effect of their combined administration is unknown. Thus, the aim of this study was to investigate the isolated and combined effects of aerobic training and arginine supplementation on metabolic variables and vascular reactivity in rats at high risk for developing the metabolic syndrome. Wistar rats were divided into two groups: control and fructose (F - water with 10 % fructose)...
July 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28798743/l-arginine-uptake-by-cationic-amino-acid-transporter-promotes-intra-macrophage-survival-of-leishmania-donovani-by-enhancing-arginase-mediated-polyamine-synthesis
#8
Abhishek Mandal, Sushmita Das, Ajay Kumar, Saptarshi Roy, Sudha Verma, Ayan Kumar Ghosh, Ruby Singh, Kumar Abhishek, Savita Saini, Abul Hasan Sardar, Bidyut Purkait, Ashish Kumar, Chitra Mandal, Pradeep Das
The survival of intracellular protozoan parasite, Leishmania donovani, the causative agent of Indian visceral leishmaniasis (VL), depends on the activation status of macrophages. l-Arginine, a semi-essential amino acid plays a crucial regulatory role for activation of macrophages. However, the role of l-arginine transport in VL still remains elusive. In this study, we demonstrated that intra-macrophage survival of L. donovani depends on the availability of extracellular l-arginine. Infection of THP-1-derived macrophage/human monocyte-derived macrophage (hMDM) with Leishmania, resulted in upregulation of l-arginine transport...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28797687/the-role-of-nitric-oxide-in-spectral-information-processing-in-the-distal-turtle-retina
#9
Elena Segal, Ido Perlman
Chromaticity type horizontal cells (C-type HCs) are the first retinal neurons exhibiting spectral information processing in cold-blooded vertebrates. The simple input of hyperpolarizing responses of cone photoreceptors is transformed in the C-type HCs into spectral opponent output. Nitric oxide (NO), a known background neuromodulator in the distal retina, was tested here for its effects upon spectral information processing by C-type HCs in the retina of turtle. Photoresponses were intracellularly recorded from C-type HCs, using light stimuli of different wavelength, applied over backgrounds of different wavelengths, and changing retinal NO level...
August 7, 2017: Vision Research
https://www.readbyqxmd.com/read/28797638/a-novel-tnfaip8-gene-mediates-l-arginine-metabolism-in-apostichopus-japonicus
#10
Yina Shao, Huahui Chen, Miao Lv, Chenghua Li, Weiwei Zhang, Ye Li, Xuelin Zhao, Yongbo Bao
Tumor necrosis factor (TNF)-α-induced protein 8 (TNFAIP8) family is a newly identified protein with vital roles in maintaining immune homeostasis. In the current study, we first cloned and characterized a TNFAIP8 gene from the invertebrate sea cucumber Apostichopus japonicus. The gene was designated as AjTNFAIP8. The full-length cDNA of AjTNFAIP8 was 1455 bp long and encoded a matured protein of 201 amino acid residues. Structural analysis indicated that AjTNFAIP8 had a death effector domain (DED)-like domain and composed of six α-helices...
August 7, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28794328/sensitive-and-simultaneous-electrochemical-sensing-for-three-dihydroxybenzene-isomers-based-on-poly-l-arginine-modified-glassy-carbon-electrode
#11
Gangbing Zhu, Heng Sun, Junjuan Qian, Xiangyang Wu, Yinhui Yi
The simultaneous and sensitive electrochemical detection of dihydroxybenzene isomers (hydroquinone, HQ; catechol, CC; resorcinol, RS) is of great significance because such isomers can be awfully harmful to the environment and human health. In this paper, by preparing poly(L-arginine) modified glassy carbon electrode (P-L-Arg/GCE) with a simple method, a highly sensitive electrochemical sensor for simultaneously detecting HQ, CC and RS was constructed successfully due to the large surface area, good electronic properties and catalytic ability of P-L-Arg/GCE and the electrostatic action between P-L-Arg (positive) and targets (negative)...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28791767/the-delivery-of-doxorubicin-of-multifunctional-%C3%AE-cyclodextrin-modified-cdse-zns-quantum-dots-for-bioactivity-and-nano-probing
#12
Mei-Xia Zhao, Bing-Jie Zhu, Wen-Jing Yao, Di-Feng Chen, Chaojie Wang
The modified quantum dots (QDs), have been used in intracellular probing and drug delivery because of their special chemical and physical properties. In this paper, two β-cyclodextrin (β-CD)-modified CdSe/ZnS QDs with strong optical emission properties were synthesized as drug carriers to induce apoptosis. The positively charged L-Arginine (L-Arg) and neutral L-Tryptophan (L-Trp) were selected as ligands to compare the effect of charge on bioactivity of QDs nanoparticles. The in vitro assays revealed that these modified QDs showed good Dox carrier ability and significantly high inhibition rate to cancer cells...
August 9, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28782772/green-tea-infusion-protects-against-alcoholic-liver-injury-by-attenuating-inflammation-and-regulating-the-pi3k-akt-enos-pathway-in-c57bl-6-mice
#13
Dongxu Wang, Qiang Gao, Taotao Wang, Guangshan Zhao, Frank Qian, Jinbao Huang, Haisong Wang, Xin Zhang, Yijun Wang
Alcohol intake is a major risk factor for the pathogenesis of alcoholic liver diseases. Accumulating evidence suggests that green tea protects against alcoholic liver injury; however, the underlying mechanisms remain unclear. The present study investigated the role of endothelial nitric oxide synthase (eNOS) in the protective effects of green tea against alcohol-induced liver injury and inflammation. Ethanol was intragastrically administered to male C57BL/6 mice once a day, and the mice were allowed free access to green tea infusion or water for two weeks...
August 7, 2017: Food & Function
https://www.readbyqxmd.com/read/28782150/mri-assessment-of-coronary-microvascular-endothelial-nitric-oxide-synthase-function-using-myocardial-t1-mapping
#14
Sophia X Cui, Frederick H Epstein
PURPOSE: Endothelial nitric oxide synthase (eNOS) plays a central role in regulating vascular tone, blood flow, and microvascular permeability. Endothelial dysfunction, including eNOS dysfunction, is an early biomarker of vascular disease. This study aimed to show that myocardial T1 mapping during nitric oxide synthase (NOS) inhibition could assess coronary microvascular eNOS function. METHODS: Wild-type mice, eNOS(-/-) mice, and wild-type mice fed a high-fat diet underwent T1 mapping at baseline and for 20 min after injection of N(G) -nitro-L-arginine methyl ester (LNAME), a NOS inhibitor...
August 7, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28780854/structures-and-mechanisms-of-the-non-heme-fe-ii-and-2-oxoglutarate-dependent-ethylene-forming-enzyme-substrate-binding-creates-a-twist
#15
Salette Martinez, Matthias Fellner, Caitlyn Q Herr, Anastasia Ritchie, Jian Hu, Robert P Hausinger
The ethylene-forming enzyme (EFE) from Pseudomonas syringae pv. phaseolicola PK2 is a member of the mononuclear non-heme Fe(II)- and 2-oxoglutarate (2OG)-dependent oxygenase superfamily. EFE converts 2OG into ethylene plus three CO2 molecules while also catalyzing the C5 hydroxylation of L-arginine (L-Arg) driven by the oxidative decarboxylation of 2OG to form succinate and CO2. Here we report eleven X-ray crystal structures of EFE that provide insight into the mechanisms of these two reactions. Binding of 2OG in the absence of L-Arg resulted in predominantly monodentate metal coordination, distinct from the typical bidentate metal-binding species observed in other family members...
August 5, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28776992/hydrophilic-potent-and-selective-7-substituted-2-aminoquinolines-as-improved-human-neuronal-nitric-oxide-synthase-inhibitors
#16
Anthony V Pensa, Maris A Cinelli, Huiying Li, Georges Chreifi, Paramita Mukherjee, Linda J Roman, Pavel Martásek, Thomas L Poulos, Richard B Silverman
Neuronal nitric oxide synthase (nNOS) is a target for development of antineurodegenerative agents. Most nNOS inhibitors mimic l-arginine and have poor bioavailability. 2-Aminoquinolines showed promise as bioavailable nNOS inhibitors but suffered from low human nNOS inhibition, low selectivity versus human eNOS, and significant binding to other CNS targets. We aimed to improve human nNOS potency and selectivity and reduce off-target binding by (a) truncating the original scaffold or (b) introducing a hydrophilic group to interrupt the lipophilic, promiscuous pharmacophore and promote interaction with human nNOS-specific His342...
August 4, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28771840/influence-of-l-carnitine-and-l-arginine-on-protein-synthesis-and-maturation-of-the-semitendinosus-muscle-of-lightweight-piglets
#17
J G Madsen, E Seoni, M Kreuzer, P Silacci, G Bee
Lightweight (LW) piglets from large litters display impaired growth performance compared with heavier littermates. This study investigated the growth performance and muscle development of early-weaned LW piglets (birthweight <1.2 kg) from large litters (17.3 ± 3.0 total born per litter), fed ad libitum a milk replacer supplemented with either l-carnitine (CAR) or l-arginine (ARG) from day 7 to day 28 of age. In total, 36 female and entire male Swiss Large White piglets, weaned on day 7 of age, were artificially reared in pairs in rescue decks...
August 3, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28771838/human-regulatory-macrophages-are-potent-in-suppression-of-the-xenoimmune-response-via-indoleamine-2-3-dioxygenase-involved-mechanism-s
#18
Fei Guo, Min Hu, Dandan Huang, Yuanfei Zhao, Benjamin Heng, Gilles Guillemin, Chai K Lim, Wayne J Hawthorne, Shounan Yi
BACKGROUND: For xenotransplantation to truly succeed, we must develop immunomodulatory strategies to suppress the xenoimmune response but by minimizing immunosuppression over the long term. Regulatory macrophages (Mreg) have been shown to suppress polyclonal T-cell proliferation in vitro and prolong allograft survival in vivo. However, the question of whether they are capable of suppressing xenoimmune responses remains unknown. This study assessed the potential of human Mreg to be used as an effective immunomodulatory method in xenotransplantation...
August 2, 2017: Xenotransplantation
https://www.readbyqxmd.com/read/28771730/in-ovo-feeding-of-l-arginine-regulates-intestinal-barrier-functions-of-posthatch-broilers-by-activating-the-mtor-signaling-pathway
#19
Tian Gao, Minmeng Zhao, Lin Zhang, Jiaolong Li, Lanlin Yu, Feng Gao, Guanghong Zhou
BACKGROUND: During the last phase of incubation, dramatic physiological and metabolic changes occur in chick embryos, and the supplies of the nutrients and energy are always insufficient. This study was to investigate the effects of in ovo feeding (IOF) of L-arginine (Arg) on the hatchability, growth performance, intestinal development and functions of posthatch broilers. RESULTS: The IOF of Arg increased (P<0.05) the feed intake and body weight gain during 1-21 d and 1-42 d, the intestinal weight of 7 and 21-d-old broilers compared with NC and DG groups...
August 3, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28770018/brain-derived-neurotrophic-factor-attenuates-septic-myocardial-dysfunction-via-enos-no-pathway-in-rats
#20
Ni Zeng, Junmei Xu, Weifeng Yao, Suobei Li, Wei Ruan, Feng Xiao
Sepsis-induced myocardial dysfunction increases mortality in sepsis, yet the underlying mechanism is unclear. Brain-derived neurotrophic factor (BDNF) has been found to enhance cardiomyocyte function, but whether BDNF has a beneficial effect against septic myocardial dysfunction is unknown. Septic shock was induced by cecal ligation and puncture (CLP). BDNF was expressed in primary cardiomyocytes, and its expression was significantly reduced after sepsis. In rats with sepsis, a sharp decline in survival was observed after CLP, with significantly reduced cardiac BDNF expression, enhanced myocardial fibrosis, elevated oxidative stress, increased myocardial apoptosis, and decreased endothelial nitric oxide (NO) synthase (eNOS) and NO...
2017: Oxidative Medicine and Cellular Longevity
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