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https://www.readbyqxmd.com/read/28938553/homocysteine-induced-peripheral-microcirculation-dysfunction-in-zebrafish-and-its-attenuation-by-l-arginine
#1
Sang Joon Lee, Sung Ho Park, Jinhyuk Fred Chung, Woorak Choi, Hyung Kyu Huh
Elevated blood homocysteine (Hcy) level is frequently observed in aged individuals and those with age-related vascular diseases. However, its effect on peripheral microcirculation is still not fully understood. Using in vivo zebrafish model, the degree of Hcy-induced peripheral microcirculation dysfunction is assessed in this study with a proposed dimensionless velocity parameter [Formula: see text], where [Formula: see text] and [Formula: see text] represent the peripheral microcirculation perfusion and the systemic perfusion levels, respectively...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938516/naturally-occurring-anthocyanin-cyanidin-3-rutinoside-possesses-inherent-vasorelaxant-actions-and-prevents-methylglyoxal-induced-vascular-dysfunction-in-rat-aorta-and-mesenteric-arterial-bed
#2
Thavaree Thilavech, Mahinda Y Abeywardena, Michael Adams, Julie Dallimore, Sirichai Adisakwattana
Cyanidin-3-rutinoside (C3R) possesses anti-oxidant, anti-inflammatory and anti-glycation properties. Methylglyoxal (MG), a highly reactive dicarbonyl aldehyde by-product of glycolysis, is a precursor of advanced glycation end products and contributes to vascular dysfunction, particularly during hyperglycemia. We investigated the possible inherent vasoactivity of C3R, and its effectiveness against MG-induced vascular abnormalities in isolated blood vessel preparations from male Wistar Kyoto rat. C3R induced vasorelaxation concentration-dependently in aortic rings (92% maximum relaxation; EC50: 2...
September 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28936791/nmda-receptors-and-no-cgmp-signaling-pathway-mediate-the-diazepam-induced-sensitization-to-withdrawal-signs-in-mice
#3
Sylwia Talarek, Joanna Listos, Jolanta Orzelska-Gorka, Anna Serefko, Jolanta Kotlińska
The goal of the present study was to examine the effects of N-methyl-aspartate (NMDA) receptor antagonists-memantine and ketamine and the drugs modifying the NO:cGMP pathway-NG-nitro-L-arginine methyl ester (L-NAME) and 7-nitroindazole (7-NI), the endogenous precursor of NO-L-arginine, and the guanylyl cyclase inhibitor-methylene blue (MB) on the development of sensitization to withdrawal signs precipitated after chronic, interrupted treatment with diazepam, a benzodiazepine receptor agonist, in mice. To develop the sensitization, the mice were divided into groups: continuously and sporadically (with two diazepam-free periods) treated with diazepam (15 mg/kg, sc)...
September 21, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28931548/fluid-replacement-modulates-oxidative-stress-but-not-nitric-oxide-mediated-cutaneous-vasodilation-and-sweating-during-prolonged-exercise-in-the-heat
#4
Brendan D McNeely, Robert D Meade, Naoto Fujii, Andrew J E Seely, Ronald J Sigal, Glen P Kenny
The roles of nitric oxide synthase (NOS), reactive oxygen species (ROS) and angiotensin II type 1 receptor (AT1R) activation in regulating cutaneous vasodilation and sweating during prolonged (≥60 min) exercise are currently unclear. Moreover, it remains to be determined whether fluid replacement (FR) modulates the above thermoeffector responses. To investigate, eleven young men completed 90-min of continuous moderate intensity (46% of VO2peak) cycling performed at a fixed rate of metabolic heat production of 600 W (No-FR condition)...
September 20, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28929917/mercurius-solubilis-attenuates-scopolamine-induced-memory-deficits-and-enhances-the-motor-coordination-in-mice
#5
Simranjeet Kaur, Anudeep Kaur, Gurjit Singh, Rajbir Bhatti
The present study was designed to investigate the effect of mercurius solubilis (Merc sol) on scopolamine induced memory deficits and motor coordination in mice. The Three different formulations of merc sol (30X, 200 M, 1 M) were screened for their in vitro antioxidant potential and DPPH (2, 2-diphenyl-1-picrylhydrazyl) and nitric oxide scavenging activity using response surface methodology. The Merc sol 30X formulation was found to be most potent and further subjected for in vivo experiment. The Memory impairment was induced by the administration of scopolamine (1 mg/kg i...
September 20, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28925566/raman-spectroscopy-for-accurately-characterising-biomolecular-changes-in-androgen-independent-prostate-cancer-cells
#6
Stella Corsetti, Thomas Rabl, David McGloin, Ghulam Nabi
Metastatic prostate cancer resistant to hormonal manipulation is considered the advanced stage of the disease and leads to most cancer related mortality. With new research focusing on modulating cancer growth, it is essential to understand the biochemical changes in cells that can then be exploited for drug discovery and for improving responsiveness to treatment. Raman spectroscopy has a high chemical specificity and can be used to detect and quantify molecular changes at the cellular level. Collection of large datasets generated from biological samples can be employed to form discriminatory algorithms for detection of subtle and early changes in cancer cells...
September 19, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28925511/morphine-hyposensitivity-in-stz-diabetic-rats-reversal-by-dietary-l-arginine-treatment
#7
Shahrdad Lotfipour, Maree T Smith
Painful diabetic neuropathy (PDN) is a long-term complication of diabetes. Defining symptoms include mechanical allodynia (pain due to light pressure or touch) and morphine hyposensitivity. In our previous work using the streptozotocin (STZ)-diabetic rat model of PDN, morphine hyposensitivity developed in a temporal manner with efficacy abolished at 3-months post-STZ and maintained for 6-months post-STZ. As this time course mimicked that for the temporal development of hyposensitivity to the pain-relieving effects of the furoxan nitric oxide (NO) donor, PRG150 (3-methylfuroxan-4-carbaldehyde) in STZ-diabetic rats, we hypothesized that progressive depletion of endogenous NO bioactivity may underpin the temporal loss of morphine sensitivity in STZ-diabetic rats...
September 19, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28919396/protective-effect-of-chlorogenic-acid-on-the-inflammatory-damage-of-pancreas-and-lung-in-mice-with-l-arginine-induced-pancreatitis
#8
Tatsuya Ohkawara, Hiroshi Takeda, Jun Nishihira
AIMS: Pancreatitis is characterized by inflammatory disease with severe tissue injury in pancreas, and the incidence of pancreatitis has been recently increasing. Although several treatments of acute pancreatitis have been developed, some patients have been resistant to current therapy. Chlorogenic acid (CGA) is one of the polyphenols, and is known to have an anti-inflammatory effect. In this study, we investigated the effects of CGA on experimental pancreatitis in mice. MATERIALS AND METHODS: Pancreatitis was induced by twice injection of l-arginine (5g/kg body weight)...
September 14, 2017: Life Sciences
https://www.readbyqxmd.com/read/28914979/systemic-evaluation-of-vascular-dysfunction-by-high-resolution-sonography-in-an-n%C3%AF-nitro-l-arginine-methyl-ester-hydrochloride-induced-mouse-model-of-preeclampsia-like-symptoms
#9
Ying Zhao, Ning Yang, Hanying Li, Wei Cai, Xin Zhang, Yongqiang Ma, Xiulong Niu, Guohong Yang, Xin Zhou, Yuming Li
OBJECTIVES: The purpose of this study was to evaluate vascular function, including arterial resistance and endothelial function, by high-resolution sonography in an Nω -nitro-l-arginine methyl ester hydrochloride (l-NAME)-induced mouse model of preeclampsia-like symptoms. METHODS: Pregnant mice were subcutaneously injected with a saline solution (control; n = 10) or l-NAME (n = 10) between the 7th and 18th days of gestation. The resistive index and pulsatility index (RI and PI, indicators of arterial resistance) of the uteroplacental, umbilical, femoral, and common carotid arteries and the flow-mediated dilatation (index of endothelial function) of the femoral artery were measured by high-frequency sonography in both groups...
September 15, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28911688/curcumin-inhibits-adenosine-deaminase-and-arginase-activities-in-cadmium-induced-renal-toxicity-in-rat-kidney
#10
Ayodele Jacob Akinyemi, Nora Onyebueke, Opeyemi Ayodeji Faboya, Sunday Amos Onikanni, Adewale Fadaka, Israel Olayide
In this study, the effect of enzymes involved in degradation of renal adenosine and l-arginine was investigated in rats exposed to cadmium (Cd) and treated with curcumin, the principal active phytochemical in turmeric rhizome. Animals were divided into six groups (n = 6): saline/vehicle, saline/curcumin 12.5 mg/kg, saline/curcumin 25 mg/kg, Cd/vehicle, Cd/curcumin 12.5 mg/kg, and Cd/curcumin 25 mg/kg. The results of this study revealed that the activities of renal adenosine deaminase and arginase were significantly increased in Cd-treated rats when compared with the control (p < 0...
April 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28911008/maternal-dietary-l-arginine-and-adverse-birth-outcomes-in-dar-es-salaam-tanzania
#11
Anne Marie Darling, Chloe R McDonald, Willy S Urassa, Kevin C Kain, Ramadhani S Mwiru, Wafaie W Fawzi
The amino acid arginine is a physiological precursor to nitric oxide, which is a key mediator of embryonic survival, fetal growth, and pregnancy maintenance. We evaluated the association between consumption of the amino acid arginine and the rate of adverse birth outcomes using data from a double-blind, randomized, placebo-controlled micronutrient supplementation trial among pregnant women in Dar es Salaam, Tanzania (2001-2004). Dietary intakes of arginine were assessed using repeated 24-hour recalls that were administered throughout pregnancy...
September 1, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28910154/activation-of-veratridine-sensitive-sodium-channels-but-not-electrical-field-stimulation-dilates-porcine-retinal-arterioles-with-preserved-perivascular-tissue
#12
Nils M Kratholm, Peter Skov Jensen, Sidse Kringelholt, Ulf Simonsen, Toke Bek
PURPOSE: Disturbances in retinal blood flow are a prominent feature of vision threatening retinal diseases. The regulation of tone in retinal resistance vessels involves the perivascular retinal tissue, but it is unknown to what extent neurons or glial cells contribute to the effect. Therefore, the purpose of the present study was to study the contribution of neurons in the perivascular retina to vascular tone during activation of voltage-gated sodium channels with veratridine and electrical field stimulation (EFS)...
September 14, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28904082/a-relative-l-arginine-deficiency-contributes-to-endothelial-dysfunction-across-the-stages-of-the-menopausal-transition
#13
Jelena Klawitter, Kerry L Hildreth, Uwe Christians, Wendy M Kohrt, Kerrie L Moreau
Vascular endothelial function declines across the menopause transition in women. We tested the hypothesis that reduced availability of the endothelial nitric oxide synthase [eNOS] substrate L-arginine is an underlying mechanism to vascular endothelial dysfunction across menopause stages. Endothelial function (brachial artery flow-mediated dilation [FMD]) and plasma markers of L-arginine metabolism (citrulline, N(G)-mono-methyl-ւ-arginine [L-NMMA] asymmetric dimethylarginine [ADMA] and N(G)-N('G)-dimethyl-l-arginine [SDMA]), were measured in 129 women: 36 premenopausal (33 ± 7 years), 16 early- (49 ± 3 years) or 21 late- (50 ± 4 years) perimenopausal, and 21 early- (55 ± 3 years) or 35 late- (61 ± 4 years) postmenopausal...
September 2017: Physiological Reports
https://www.readbyqxmd.com/read/28901890/dietary-l-arginine-inhibits-intestinal-clostridium-perfringens-colonisation-and-attenuates-intestinal-mucosal-injury-in-broiler-chickens
#14
Beibei Zhang, Zengpeng Lv, Huixian Li, Shuangshuang Guo, Dan Liu, Yuming Guo
We investigated the effects of dietary l-arginine level and feeding duration on the intestinal damage of broilers induced by Clostridium perfringens (CP) in vivo, and the antimicrobial effect of its metabolite nitric oxide (NO) in vitro. The in vivo experiment was designed as a factorial arrangement of three dietary treatments×two challenge statuses. Broilers were fed a basal diet (CON) or a high-arginine diet (ARG) containing 1·87 % l-arginine, or CON for the first 8 d and ARG from days 9 to 28 (CON/ARG)...
September 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28901858/expression-of-a-nitric-oxide-synthesizing-protein-in-arterial-endothelial-cells-in-response-to-different-anti-anginal-agents-used-in-acute-coronary-syndromes
#15
Sarbashri Bank, Pradipta Jana, G V Girish, Asru Sinha, Smarajit Maiti
Organic "nitro" compounds such as nitroglycerine, isosorbate nitrate are useful in the control of chest pain in acute coronary syndrome. But the mechanism of it in pain regulation remains speculative. Here, increase of NO production was investigated by the possible regulation of constitutive nitric oxide synthase (cNOS) function from goat arterial endothelial cells. This protein was purified and sequence wise characterized as protein disulfide isomerase (PDI) in response to different nitro compounds. The NO generating protein was isolated from arterial endothelial cells and prepared to homogeneity...
September 11, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28901462/role-of-ghrelin-in-small-intestinal-motility-following-pediatric-intracerebral-hemorrhage-in-mice
#16
Jieyu Zan, Lei Song, Jiejie Wang, Rong Zou, Fei Hong, Jinhua Zhao, Yijun Cheng, Ming Xu
Small intestinal motility (SIM) disorder is a common complication following pediatric intracerebral hemorrhage (ICH), leading to a poor prognosis in patients. Previous studies have shown that ghrelin is involved in SIM in various diseases; however, the role of ghrelin in pediatric ICH‑induced SIM disorder remains to be elucidated. The present study was designed to investigate the association between ghrelin and SIM post‑ICH, and to examine the effect of exogenous ghrelin administration on SIM in vivo...
September 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28900851/tributyltin-chloride-disrupts-aortic-vascular-reactivity-and-increases-reactive-oxygen-species-production-in-female-rats
#17
Carolina Falcão Ximenes, Samya Mere Lima Rodrigues, Priscila Lang Podratz, Eduardo Merlo, Julia Fernandez Puñal de Araújo, Lívia Carla Melo Rodrigues, Juliana Barbosa Coitinho, Dalton Valentim Vassallo, Jones Bernardes Graceli, Ivanita Stefanon
Organotin compounds, such as tributyltin (TBT), are environment contaminants that induce bioaccumulation and have potential toxic effects on marine species and mammals. TBT have been banned by the International Maritime Organization in 2003. However, the assessment of butyltin and metal contents in marine sediments has demonstrated high residual levels of TBT in some cases exceeding 7000 ng Sn g(-1). The acceptable daily intake (ADI) level for TBT established by the World Health Organization is 0.5 μg/kg bw/day is based on genotoxicity, reproduction, teratogenicity, immunotoxicity, and mainly neurotoxicity...
September 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28900611/the-protective-effect-of-l-arginine-in-cisplatin-induced-nephrotoxicity-in-streptozotocin-induced-diabetic-rats
#18
Fatemeh Gharibi, Nepton Soltani, Maryam Maleki, Ardeshir Talebi, Masoumeh Nasiri, Soheyla Shirdavani, Mehdi Nematbakhsh
BACKGROUND: Cisplatin (CP) is accompanied with a nephrotoxicity. L-arginine (LA) plays an important role in the regulation of renal function. The present study was designed to investigate the protective role of LA supplementation in CP-induced nephrotoxicity in a diabetic rat's model. MATERIALS AND METHODS: Sixteen adult female and male Wistar rats were used and they received a single dose of streptozotocin (STZ) (60 mg/kg i.p.). Diabetic female and male rats were arranged as groups 1-5 and groups 6-10, respectively...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28899928/treatment-of-hypertension-by-increasing-impaired-endothelial-trpv4-kca2-3-interaction
#19
Dongxu He, Qiongxi Pan, Zhen Chen, Chunyuan Sun, Peng Zhang, Aiqin Mao, Yaodan Zhu, Hongjuan Li, Chunxiao Lu, Mingxu Xie, Yin Zhou, Daoming Shen, Chunlei Tang, Zhenyu Yang, Jian Jin, Xiaoqiang Yao, Bernd Nilius, Xin Ma
The currently available antihypertensive agents have undesirable adverse effects due to systemically altering target activity including receptors, channels, and enzymes. These effects, such as loss of potassium ions induced by diuretics, bronchospasm by beta-blockers, constipation by Ca(2+) channel blockers, and dry cough by ACEI, lead to non-compliance with therapies (Moser, 1990). Here, based on new hypertension mechanisms, we explored a new antihypertensive approach. We report that transient receptor potential vanilloid 4 (TRPV4) interacts with Ca(2+)-activated potassium channel 3 (KCa2...
September 12, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28899912/do-nitric-oxide-synthase-and-cyclooxygenase-contribute-to-sweating-response-during-passive-heating-in-endurance-trained-athletes
#20
Tatsuro Amano, Naoto Fujii, Glen P Kenny, Yoshimitsu Inoue, Narihiko Kondo
The aim of our study was to determine if habitual endurance training can influence the relative contribution of nitric oxide synthase (NOS) and cyclooxygenase (COX) in the regulation of sweating during a passive heat stress in young adults. Ten trained athletes and nine untrained counterparts were passively heated until oral temperature (as estimated by sublingual temperature, Tor) increased by 1.5°C above baseline resting. Forearm sweat rate (ventilated capsule) was measured at three skin sites continuously perfused with either lactated Ringer's solution (Control), 10 mmol/L N(G) -nitro-L-arginine methyl ester (L-NAME, non-selective NOS inhibitor), or 10 mmol/L ketorolac (Ketorolac, non-selective COX inhibitor) via intradermal microdialysis...
September 2017: Physiological Reports
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