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"Grape seed extract"

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https://www.readbyqxmd.com/read/29051443/vitis-vinifera-extract-ameliorate-hepatic-and-renal-dysfunction-induced-by-dexamethasone-in-albino-rats
#1
Nabil A Hasona, Ahmed A Alrashidi, Thamer Z Aldugieman, Ali M Alshdokhi, Mohammed Q Ahmed
This study was conducted to evaluate the biochemical effects of grape seed extract against dexamethasone-induced hepatic and renal dysfunction in a female albino rat. Twenty-eight adult female rats were divided randomly into four equal groups: Group 1: animals were injected subcutaneously with saline and consider as normal control one. Group 2: animals were injected subcutaneously with dexamethasone in a dose of 0.1 mg/kg body weight. Group 3: animals were injected subcutaneously with 0.1 mg/kg body weight of dexamethasone, and then treated with a grape seed extract in a dose of 200 mg/kg body weight by oral gavage...
April 11, 2017: Toxics
https://www.readbyqxmd.com/read/28987724/effect-of-proanthocyanidin-enriched-extracts-on-the-inhibition-of-wear-and-degradation-of-dentin-demineralized-organic-matrix
#2
Ana Paula Boteon, Melissa Thiemi Kato, Marília Afonso Rabelo Buzalaf, Anuradha Prakki, Linda Wang, Daniela Rios, Heitor Marques Honório
OBJECTIVES: The aim of this study was to evaluate the effect of Cranberry and Grape seed-enriched extract gels in inhibiting wear and degradation of demineralized organic matrix (DOM). DESIGN: 225 dentin specimens obtained from bovine incisors were randomly allocated into 5 groups (n=45): 10% Grape seed extract gel (GSE), 10% Cranberry extract gel (CE), 0.012% Chlorhexidine gel (CX), 1.23% NaF gel (F), and no active compound gel (P, placebo). Before the treatments, samples were demineralized by immersion in 0...
September 25, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28983752/cytotoxicity-and-apoptotic-cell-death-induced-by-vitis-vinifera-peel-and-seed-extracts-in-a431-skin-cancer-cells
#3
J Grace Nirmala, S Evangeline Celsia, Akila Swaminathan, R T Narendhirakannan, Suvro Chatterjee
Vitis vinifera. L is one of the most widely consumed fruits in the world and are rich in antioxidant abundant polyphenols. The present study was carried out to assess the antiproliferative and apoptotic effects of Vitis vinifera peel and seed extracts in an in vitro model using human epidermoid carcinoma A431 cell lines. Vitis vinifera peel and seed extracts were incubated with A431 cells to evaluate the antiproliferative, apoptotic effects and the morphological apoptotic changes induced by the extracts. Mitochondrial membrane potential was also measured after incubating the cells with extracts...
October 5, 2017: Cytotechnology
https://www.readbyqxmd.com/read/28963764/valorization-of-underutilized-north-american-pawpaw-asimina-triloba-investigation-as-a-lipid-oxidation-inhibitor-in-turkey-homogenate-model-system
#4
Robert G Brannan, Trisha E Peters, Kathleen J Black, Benjamin J Kukor
BACKGROUND: The objective of this study was to characterize the ability of extracts from nine varieties of pawpaw pulp standardized to the phenolics level of 0.1% grape seed extract (GSE) on inhibition of the formation of thiobarbituric reactive substances (TBARS) in a turkey model system. The antioxidant activity of the extracts was also determined using four common assays. RESULTS: Over the 240 min sampling time, the standardized pawpaw extracts from all nine varieties were as effective as GSE in inhibiting TBARS formation in turkey muscle homogenate compared to the untreated control...
September 30, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28943000/histological-and-immunohistochemical-study-of-cardiac-telocytes-in-a-rat-model-of-isoproterenol-induced-myocardial-infarction-with-a-reference-to-the-effect-of-grape-seed-extract
#5
Mai Salah Nour, Nahla Reda Sarhan, Shireen A Mazroa, Salwa A Gawish
INTRODUCTION: Cardiac telocytes (TCs) represent a unique type of cells that make a supportive network for stem cells that contribute in cardiac renewal, but their role during myocardial infarction (MI) is not clear. Grape seed extract (GSE) is a powerful natural antioxidant. AIM OF THE WORK: Quantitative study of cardiac TCs in a rat model of Isoproterenol (ISO)-induced MI, and to evaluate the effect of GSE on TCs and MI progression. MATERIALS AND METHODS: Seventy adult male albino rats were assigned into 4 groups; group I; control rats, group II received GSE (100mg/kg/day) dissolved in distilled water orally, group III received 2 intra-peritoneal injections of 85mg/kg ISO dissolved in saline on 14th and 15th day to induce MI, and group IV received GSE and ISO...
September 21, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28924329/a-computational-tool-for-accelerated-analysis-of-oligomeric-proanthocyanidins-in-plants
#6
Mengliang Zhang, Jianghao Sun, Pei Chen
A computational tool was developed to facilitate proanthocyanidin analysis using data collected by ultra-high-performance liquid chromatography-diode array detection-high resolution accurate mass-mass spectrometry (UHPLC-DAD-HRAM-MS). Both identification and semi-quantitation of proanthocyanidins can be achieved by the developed computational tool. It can extract proanthocyanidin chromatographic peaks, deconvolute the isotopic patterns of A-type, B-type, and multi-charged proanthocyanidins ions, and predict proanthocyanidin structures...
March 2017: Journal of Food Composition and Analysis
https://www.readbyqxmd.com/read/28903761/protective-effects-of-grape-seed-and-skin-extract-against-high-fat-diet-induced-lipotoxicity-in-rat-lung
#7
Mohamed El Ayed, Safwen Kadri, Selima Smine, Salem Elkahoui, Ferid Limam, Ezzedine Aouani
BACKGROUND: Obesity is a public health problem characterized by increased fat accumulation in different tissues. Obesity is directly linked to breathing problems and medical complications with lung, including obstructive sleep apnea syndrome, obesity hypoventilation syndrome, chronic obstructive pulmonary disease, asthma….In the present work, we aimed to investigate the effect of high fat diet (HFD) on lung lipotoxicity, oxidative stress, fatty acid composition and proportions in lung and implication in asthma development...
September 13, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28881609/grape-seed-extracts-modify-the-outcome-of-oxaliplatin-in-colon-cancer-cells-by-interfering-with-cellular-mechanisms-of-drug-cytotoxicity
#8
Letizia Porcelli, Rosa Maria Iacobazzi, Anna Elisa Quatrale, Carlo Bergamini, Nunzio Denora, Pasquale Crupi, Donato Antonacci, Anita Mangia, Giovanni Simone, Nicola Silvestris, Amalia Azzariti
Grape seed extracts are commonly utilized as dietary supplements for their antioxidant properties, even from cancer patients. However, whether these natural extracts interfere with chemotherapeutics utilized in colon cancer treatment is still poorly investigated. The cytotoxicity of extracts from Italia and Palieri cultivars either alone or in combination with oxaliplatin was evaluated in colon cancer cells. Grape seed extracts displayed anti-proliferative activity depending on the concentration utilized through apoptosis induction...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28877280/mechanical-properties-water-sorption-characteristics-and-compound-release-of-grape-seed-extract-incorporated-resins
#9
Don Jeevanie Epasinghe, Cynthia Kar Yung Yiu, Michael Francis Burrow
Objective: This study evaluated the effect of grape seed extract (GSE) incorporation on the mechanical properties, water sorption, solubility, and GSE release from the experimental adhesive resins. Material and Methods: An experimental comonomer mixture, consisting of 40% Bis-GMA, 30% Bis MP, 28% HEMA, 0.26% camphorquinone and 1% EDMAB, was used to prepare four GSE-incorporated adhesive resins at concentrations of 0.5, 1, 1.5, and 2 wt%. The neat resin without GSE was used as the control...
July 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28876465/procyanidin-b2-3-3%C3%A2-di-o-gallate-induces-oxidative-stress-mediated-cell-death-in-prostate-cancer-cells-via-inhibiting-map-kinase-phosphatase-activity-and-activating-erk1-2-and-ampk
#10
Rahul Kumar, Gagan Deep, Michael F Wempe, Joseph Surek, Amit Kumar, Rajesh Agarwal, Chapla Agarwal
Neoplastic cells exhibit higher oxidative stress compared to normal cells; however, antioxidants based clinical trials have mostly failed. Another attractive therapeutic approach is to further increase the oxidative stress in cancer cells leading to cell death. Herein, we show that Procyanidin B2 3,3″-di-O-gallate (B2G2), the most active constituent of grape seed extract, treatment causes cell death in human prostate cancer (PCa) cells (LNCaP and 22Rv1) via increasing the reactive oxygen species (ROS) generation...
September 6, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28875188/alterations-to-metabolically-active-bacteria-in-the-mucosa-of-the-small-intestine-predict-anti-obesity-and-anti-diabetic-activities-of-grape-seed-extract-in-mice
#11
Laura E Griffin, Katherine A Witrick, Courtney Klotz, Melanie R Dorenkott, Katheryn M Goodrich, Gabrielle Fundaro, Ryan P McMillan, Matthew W Hulver, Monica A Ponder, Andrew P Neilson
Epidemiological and clinical studies suggest that grapes and grape-derived products may reduce the risk for chronic disease. Grape seed extract specifically has been gaining interest due to its reported ability to prevent weight gain, moderate hyperglycemia, and reduce inflammation. The purpose of this study was to examine the long-term effects of two doses of grape seed extract (10 and 100 mg kg(-1) body wt per d in mice) on markers of metabolic syndrome in the context of a moderately high-fat diet. After 12 weeks, the lower dose of grape seed extract was more effective at inhibiting fat gain and improving glucose tolerance and insulin sensitivity...
October 18, 2017: Food & Function
https://www.readbyqxmd.com/read/28868839/effect-of-grape-seed-extract-on-lipid-profile-and-expression-of-interleukin-6-in-polycystic-ovarian-syndrome-wistar-rat-model
#12
Zohreh Salmabadi, Homa Mohseni Kouchesfahani, Kazem Parivar, Latifeh Karimzadeh
Background: Polycystic ovary syndrome (PCOS) is a common but complex endocrine disorder and is the major cause of anovulation and consequent subfertility. In this study the effect of grape seed extract (GSE) on triglyceride (TG), total cholesterol (TC), highdensity lipoprotein-cholestrol (HDL-C), low-density lipoprotein-cholestrol (LDL-C) and interleukin-6 (IL-6) in PCOS Wistar rats were assessed. MATERIALS AND METHODS: In this experimental study, 84 adult female Wistar rats were divided into 7 groups (n=12) including control (intact), Sham (estradiol valerate solvent injection), control PCOS and 4 experimental PCOS groups...
October 2017: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/28855760/comparative-evaluation-of-chlorhexidine-grape-seed-extract-riboflavin-chitosan-modification-on-microtensile-bond-strength-of-composite-resin-to-dentin-after-polymerase-chain-reaction-thermocycling-an-in-vitro-study
#13
Rani Samyukta Gajjela, R Kalyan Satish, Girija S Sajjan, K Madhu Varma, T Rambabu, B H Vijaya Lakshmi
AIM: The purpose of this study was to evaluate the influence of chlorhexidine (CHX), grape seed extract (GSE), riboflavin/chitosan modification on microtensile bond strength (μTBS) of composite resin to dentin after polymerase chain reaction (PCR) thermocycling. MATERIALS AND METHODS: Forty extracted human molars were used and a flat surface was then prepared by removing the occlusal one-third. The teeth were randomly assigned into four groups - Group I in which self-etch adhesive (Adper Easy One) was applied and Groups II, III, IV were pretreated with 2% CHX, 6...
March 2017: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/28819809/effect-of-synthetic-and-natural-derived-novel-endodontic-irrigant-solutions-on-mechanical-properties-of-human-dentin
#14
Doglas Cecchin, Vitória Soares Giaretta, Bérove Granella Cadorin, Matheus Albino Souza, Cristina de Mattos Pimenta Vidal, Ana Paula Farina
This study aimed to evaluate the effects of different synthetic and natural-derived root canal irrigants (6% sodium hypochlorite [NaOCl], 6% calcium hypochlorite [Ca(OCl)2] and 6.5% grape seed extract [GSE]) on dentin mechanical properties (flexural strength, ultimate tensile strength [UTS] and fracture resistance). Rectangular-shaped beams and hourglass-shaped sections obtained from mid-coronal and root dentin were treated with 6% NaOCl, 6% Ca(OCl)2 or 6.5% GSE for 30 min. The irrigant solutions were replaced every 5 min...
August 17, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28760744/proanthocyanidin-trimer-gallate-modulates-lipid-deposition-and-fatty-acid-desaturation-in-caenorhabditis-elegans
#15
Yu Nie, Brad Littleton, Thomas Kavanagh, Vincenzo Abbate, Sukhvinder S Bansal, David Richards, Peter Hylands, Stephen R Stürzenbaum
The incidence of obesity is rising at an alarming rate. Despite its recognition as an urgent healthcare concern, obesity remains largely an unsolved medical problem. A comprehensive screen for functional dietary phytochemicals identified proanthocyanidins as putative targets to ameliorate obesity. A full-scale purification of oligomeric proanthocyanidins (OPCs) derived from grape seed extract, yielded pure OPC dimer, trimer, tetramer, and their gallates (pOPCs). Forward chemical screening conducted in Caenorhabditis elegans suggested that pOPCs reduced the activity of lipase in vitro and triglyceride storage capacity in vivo Proanthocyanidin trimer gallate in particular modified lipid desaturation in C...
July 31, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28751073/efficacy-of-new-natural-biomodification-agents-from-anacardiaceae-extracts-on-dentin-collagen-cross-linking
#16
M A Moreira, N O Souza, R S Sousa, D Q Freitas, M V Lemos, D M De Paula, F J N Maia, D Lomonaco, S E Mazzetto, V P Feitosa
OBJECTIVES: Several polyphenols from renewable sources were surveyed for dentin biomodification. However, phenols from cashew nut shell liquid (CNSL, Anacardium occidentale) and from Aroeira (Myracrodruon urundeuva) extract have never been evaluated. The present investigation aimed to compare the dentin collagen crosslinking (biomodification) effectiveness of polyphenols from Aroeira stem bark extract, proanthocyanidins (PACs) from grape-seed extract (Vitis vinifera), cardol and cardanol from CNSL after clinically relevant treatment for one minute...
July 24, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28687392/characterization-and-in-vitro-anticancer-properties-of-chitosan-microencapsulated-flavan-3-ols-rich-grape-seed-extracts
#17
Michelangelo Iannone, Rosario Mare, Donatella Paolino, Agnese Gagliardi, Francesca Froiio, Donato Cosco, Massimo Fresta
Studies have fully demonstrated that a diet rich in fruit and vegetables may reduce the incidence of tumors. In particular, Grape Seed Extract (GSE) has been shown to carry on chemopreventive and antitumor activity thanks to the numerous beneficial substances it contains. The purpose of this work was to create a biocompatible matrix containing GSE in order to obtain microparticles able to modulate its biopharmaceutical parameters. The spray-drying technique was chosen in order to realize chitosan microparticles characterized by a mean diameter of 4-10μm and a positive surface charge that decreased after GSE encapsulation...
November 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28654207/the-effect-of-obesity-and-repeated-exposure-on-pharmacokinetic-response-to-grape-polyphenols-in-humans
#18
Janet A Novotny, Tzu-Ying Chen, Anton I Terekhov, Sarah K Gebauer, David J Baer, Lap Ho, Giulio M Pasinetti, Mario G Ferruzzi
SCOPE: Evidence suggests that dietary pattern may affect polyphenol absorption and/or metabolism. Further, obesity is associated with lower circulating nutrients, though the reason is unclear. We investigated the pharmacokinetic (PK) response of polyphenols in obese/overweight versus lean individuals before and after repeated dosing of grape polyphenols. METHODS AND RESULTS: A pilot study was conducted in which PK challenges were administered before and after 10 days of repeated dosing with polyphenols...
November 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28629290/functional-foods-how-functional-are-they-a-case-report-of-supplement-induced-psychosis
#19
Priyanka Yadav, Kyle Stigall, Hannah E Johnson, Abner O Rayapati, Nitin Chopra
There is rising evidence of patients' use of alternative and complementary medicine. The percentage of the U.S. population who used at least one dietary supplement increased from 42% in 1988-1994 to 53% in 2003-2006. We present a case of an Asian female in her 40s, with no previous psychiatric illness, who presented to the emergency room following a brief psychotic episode, during which she self-amputated the tips of her fingers, after using multivitamins and herbal supplements including ginseng, gui yuan rou (Chinese herb), astaxanthin, goji (Chinese fruit), selenium, saw palmetto, grape seed extract, citrus bioflavanoid, lutein (zeaxantin), resvexatrol, sun chlorella, spirulina powder, phytoceramides, phytoestrogen, glucosatrin, bromelain plus, and American bee pollen...
August 2016: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/28587960/mathematical-modeling-of-gallic-acid-release-from-chitosan-films-with-grape-seed-extract-and-carvacrol
#20
Javiera F Rubilar, Rui M S Cruz, Rommy N Zuñiga, Igor Khmelinskii, Margarida C Vieira
Controlled release of antimicrobial and antioxidant compounds from packaging films is of utmost importance for extending the shelf-life of perishable foods. This study focused on the mathematical modeling of gallic acid release into an aqueous medium from three chitosan films, formulated with grape seed extract (GSE) and carvacrol. We quantified the release by HPLC technique during 30days at three temperatures (5, 25 and 45°C). The diffusion coefficients, varying with temperature according to an Arrhenius-type relationship, and the respective activation energies for Film-1 and Film-2 were, respectively [Formula: see text] m(2)s(-1) and [Formula: see text] m(2)s(-1), Ea1=58kJmol(-1) and Ea2=60kJmol(-1) as obtained from the Fickian fit...
November 2017: International Journal of Biological Macromolecules
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