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"Grape seed extract"

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https://www.readbyqxmd.com/read/29768882/grape-seed-extract-alone-or-combined-with-atropine-in-treatment-of-malathion-induced-neuro-and-genotoxicity
#1
Omar M E Abdel-Salam, Asmaa F Galal, Mahrousa M Hassanane, Lamiaa M Salem, Somaia A Nada, Fatma A Morsy
The aim of this study was to investigate the effect of treatment with grape seed extract (GSE) on the neurotoxic and genotoxic effects of acute malathion exposure. Rats received malathion (150 mg/kg by i.p. injection) for two successive days alone or combined with GSE at doses of 150 or 300 mg/kg, orally or with GSE at 300 mg/kg and atropine at a dose of 2 mg/kg, i.p. Malondialdehyde (MDA), reduced glutathione (GSH), nitric oxide, paraoxonase (PON1) were determined in cortex, striatum, and rest of brain tissue (subcortex)...
January 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29740325/extract-enriched-in-flavan-3-ols-and-mainly-procyanidin-dimers-improves-metabolic-alterations-in-a-mouse-model-of-obesity-related-disorders-partially-via-estrogen-receptor-alpha
#2
Daniela Leonetti, Raffaella Soleti, Nicolas Clere, Luisa Vergori, Caroline Jacques, Lucie Duluc, Catherine Dourguia, Maria C Martínez, Ramaroson Andriantsitohaina
Red wine polyphenol extracts improve cardiovascular and metabolic disorders linked to obesity. Their vascular protection is mediated by the activation of the alpha isoform of the estrogen receptor (ERα). In the present study, we explored the effects of a grape seed extract (GSE) enriched in the flavan-3-ols procyanidin dimers on obesity-related cardiovascular and metabolic disorders; with a particular interest in the role/contribution of ERα. Ovariectomized wild type or ERα knockout (KO) mice were fed with standard or western diet, supplemented or not with GSE, for 12 weeks...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29720929/antioxidant-effects-of-compound-walnut-oil-capsule-in-mice-aging-model-induced-by-d-galactose
#3
Huandong Zhao, Jian Li, Juan Zhao, Yang Chen, Caiping Ren, Yuxiang Chen
Background: Many plant original foods have been shown beneficial effects in humans. In the previous work, we have developed a compound capsule which contains major constituents of walnut oil and grape seed extract. Objective: To investigate the antioxidant effects of the Compound Walnut Oil Capsule (WOC) in aging model induced by D-gal. Design: 70 C57BL/6J mice were randomly divided into seven groups. Mice in normal group received daily subcutaneous injection of saline while the control group, WOC groups, Vitamin C (VC) group and pure walnut oil group received daily subcutaneous injection of D-galactose (D-gal) for 8 weeks...
2018: Food & Nutrition Research
https://www.readbyqxmd.com/read/29719667/effects-of-chitosan-edible-coating-containing-grape-seed-extract-on-the-shelf-life-of-refrigerated-rainbow-trout-fillet
#4
Parviz Hassanzadeh, Mehran Moradi, Nasim Vaezi, Mir-Hassan Moosavy, Razzagh Mahmoudi
In recent years, use of edible coatings as carriers of food additives and antimicrobial compounds has been considered in fishery products. This study was carried out to evaluate the effects of 2.00% chitosan coating singly and combined with 0.10% grape seed extract (GSE) on microbial (mesophils and psychrophils counts), chemical (thiobarbituric acid; TBA), pH and peroxide value (PV) and sensorial properties of rainbow trout fillet stored at 4 ° C over a period of 15 days. The coating had a significant effect in reducing aerobic mesophilic and psychrophilic bacteria counts...
2018: Veterinary Research Forum
https://www.readbyqxmd.com/read/29701895/interactions-between-flavonoid-rich-extracts-and-sodium-caseinate-modulate-protein-functionality-and-flavonoid-bioaccessibility-in-model-food-systems
#5
Jennifer L Elegbede, Min Li, Owen G Jones, Osvaldo H Campanella, Mario G Ferruzzi
With growing interest in formulating new food products with added protein and flavonoid-rich ingredients for health benefits, direct interactions between these ingredient classes becomes critical in so much as they may impact protein functionality, product quality, and flavonoids bioavailability. In this study, sodium caseinate (SCN)-based model products (foams and emulsions) were formulated with grape seed extract (GSE, rich in galloylated flavonoids) and green tea extract (GTE, rich in nongalloylated flavonoids), respectively, to assess changes in functional properties of SCN and impacts on flavonoid bioaccessibility...
April 27, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29684110/mechanistic-insights-into-anticancer-properties-of-oligomeric-proanthocyanidins-from-grape-seeds-in-colorectal-cancer
#6
Preethi Ravindranathan, Divya Pasham, Uthra Balaji, Jacob Cardenas, Jinghua Gu, Shusuke Toden, Ajay Goel
Although the anticancer properties of oligomeric proanthocyanidins (OPCs) from grape seeds have been well recognized, the molecular mechanisms by which they exert anticancer effects are poorly understood. In this study, through comprehensive RNA-sequencing-based gene expression profiling in multiple colorectal cancer cell lines, we for the first time illuminate the genome-wide effects of OPCs from grape seeds in colorectal cancer. Our data revealed that OPCs affect several key cancer-associated genes. In particular, genes involved in cell cycle and DNA replication were most significantly and consistently altered by OPCs across multiple cell lines...
April 19, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29683391/grape-seed-extract-supplementation-attenuates-the-blood-pressure-response-to-exercise-in-prehypertensive-men
#7
Jong-Kyung Kim, Kyung-Ae Kim, Hyun-Min Choi, Seung-Kook Park, Charles L Stebbins
We tested the hypothesis that exaggerated pressor responses observed in prehypertensive males (N = 9) during dynamic exercise are attenuated following acute dietary supplementation with grape seed extract (GSE) (i.e., a single dose). Effects of placebo and GSE (300 mg) on systolic blood pressure, diastolic blood pressure, mean arterial pressure (MAP), cardiac output (CO), stroke volume (SV), total vascular conductance (TVC), and rate × pressure product (RPP) in response to two submaximal cycling workloads (40% and 60% VO2peak ) were compared 2 h after ingestion of GSE or placebo on different days, 1 week apart...
April 23, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29628657/effect-of-different-antioxidants-on-reversing-compromised-resin-bond-strength-after-enamel-bleaching-an-in-vitro-study
#8
Hulas Gogia, Sonali Taneja, Mohit Kumar, Sonal Soi
Objective: The effect of 10% sodium ascorbate, 10% α-tocopherol, 10% grape seed extract, and 10% guava seed extract solutions on the shear bond strength (SBS) of composite resin to bleached enamel was evaluated. Materials and Methods: Labial enamel surfaces of 72 extracted maxillary central incisors were bleached using 37.5% hydrogen peroxide. Sixty-four specimens were divided into four experimental groups (Group I-IV) comprising 16 specimens each and remaining eight specimens were placed in Group V...
January 2018: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29578242/proanthocyanidin-rich-grape-seed-extract-modulates-intestinal-microbiota-in-ovariectomized-mice
#9
Guangwen Jin, Yoshinori Asou, Kirika Ishiyama, Atsushi Okawa, Taro Kanno, Yoshimi Niwano
Grape-seed extract (GSE) is rich in proanthocyanidins (polymers of flavan-3-ols). GSE is well known to have various beneficial effects to health. The objective of this study was to examine the effect of dietary GSE on the intestinal microbiota in ovariectomized (OVX) mice as a model of menopause. Phylum-level analyses using 16S rRNA-targeted group-specific polymerase-chain reaction primers in fecal samples collected 8 weeks postoperatively from OVX mice revealed that the proportion of Firmicutes and Bacteroidetes populations became imbalanced as compared with that in sham-operated control mice...
March 26, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29569905/a-novel-antihypertensive-prodrug-from-grape-seed-proanthocyanidins-extracts-via-acid-mediated-depolymerization-in-the-presence-of-captopril-synthesis-process-optimization-and-metabolism-in-rats
#10
Can Cui, Ailong Shi, Shuang Bai, Pengyu Yan, Qing Li, Kaishun Bi
Grape seed extract contain a high content of proanthocyanidins that can be depolymerized into C-4 substituted (epi)catechin derivatives in the presence of nucleophiles. However, the biological and medicinal values of depolymerisation products have been rarely investigated. Recently we developed a novel depolymerisation product (-)-epicatechin-4β-S-captopril methyl ester (ECC) derived from the reaction of grape seed proanthocyanidin extract with captopril in the presence of acidified methanol. A central composite design (CCD) was employed to select the most appropriate depolymerisation temperature and time to obtain the target product ECC with high yield...
March 23, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29563824/in-vivo-validation-of-the-multicomponent-powder-vitachelox-%C3%A2-against-the-deposition-of-polluting-ions
#11
Luca Giacomelli, Stefano Togni, Martino Meneghin, Roberto Eggenhöffner, Giada Maramaldi
Purpose: The purpose of this in vivo study is to evaluate the acute clinical application of a multicomponent powder (Vitachelox® ), including three naturally occurring standardized extracts rich in polyphenols (grape seed extract, green tea extract, oak wood/bark extract), on healthy volunteers by measuring prevention of any metal deposition within the stratum corneum (SC) following a 6-h exposure period in a polluted environment. Patients and methods: In this in vivo study, we evaluated the skin protective activity of the multicomponent powder formulated in a base emulsion compared to a relevant placebo cream...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29527700/grape-seed-extract-attenuates-dexamethasone-induced-testicular-and-thyroid-dysfunction-in-male-albino-rats
#12
N A Hasona
This study scrutinised the ameliorative properties of grape seed extract (GSE) in dexamethasone (DEX)-induced testicular and thyroid dysfunction associated with oxidative stress in male albino rats. Thirty-two healthy adult male albino rats were divided into four groups of eight animals each: normal, DEX control, DEX + GSE (200 mg/kg body weight) group and DEX + GSE (400 mg/kg body weight) group. The body weight gain and testes weight were assessed. Plasma testosterone and thyroid profile were determined...
March 12, 2018: Andrologia
https://www.readbyqxmd.com/read/29430093/grape-seed-extract-an-innovation-in-remineralization
#13
Ketaki Dinkar Jawale, Sharad Basavraj Kamat, Jayakumar Appasaheb Patil, Girish Shankar Nanjannawar, Rutuja Vijay Chopade
Aim: The aim of this study was to determine remineralizing potential of grape seed extract (GSE) compared to casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and calcium glycerophosphate (CaGP) through pH-cycling model and subsequent evaluation using polarized light microscope (PLM). Subjects and Methods: Twenty sound human teeth fragments of ten teeth were obtained from the cervical portion of the roots and were stored in demineralizing solution for 96 h at 37°C to induce artificial root carious lesion...
November 2017: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29386775/the-effects-of-endodontic-substances-and-naturally-reducing-agents-on-the-bond-strength-of-epoxy-resin-based-sealer-to-root-dentin
#14
Doglas Cecchin, Ana Paula Farina, Ana Karina Bedran-Russo
Aim: To evaluate the effects of sodium hypochlorite (NaOCl), chlorhexidine (CHX), and two naturally derived reducing agents on the bond strength of epoxy resin-based sealer to root dentin. Materials and Methods: A total of 60 single-rooted human teeth were prepared using ProTaper (Dentsply Tulsa Dental Specialties, Johnson City, TN, USA) and an irrigation protocol including 5% NaOCl or 2% CHX gel, and ethylenediaminetetraacetic acid (EDTA), for smear layer removal...
September 2017: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29372043/mast-cells-and-pro-inflammatory-cytokines-roles-in-assessment-of-grape-seeds-extract-anti-inflammatory-activity-in-rat-model-of-carrageenan-induced-paw-edema
#15
Amany Ahmed Mohamed Abd-Allah, Nasr Abdelwahab Mohamed Nasr El-Deen, Wafaa Abdou Mohamed Mohamed, Fatma Mohamed Naguib
Objectives: Reactive oxygen species (ROS)-produced oxidative disorders were involved at the pathophysiology of many inflammatory processes via the generation of pro-inflammatory cytokines and antioxidant defense system suppression. Although herbal antioxidants as mono-therapy relief many inflammatory diseases including, autoimmunity rheumatoid arthritis, but as combination therapy with other proven anti-inflammatory drugs in order to decreasing their toxic impacts has not yet been studied clearly, especially against chemical substances that's induced local inflammation with characteristic edema...
January 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29358802/effect-of-plant-extracts-on-lipid-and-protein-oxidation-of-mackerel-scomber-scombrus-mince-during-frozen-storage
#16
Berna Özalp Özen, Ayla Soyer
The effects of different plant extracts [green tea extract (GTE), grape seed extract (GSE), and pomegranate rind extract (PRE)] at a level of 100 ppm equivalent phenolics and butylated hydroxytoluene (BHT) on the changes in quality of fish ( Scomber scombrus ) mince during 6 months frozen storage at -18 ± 1 °C were investigated. During storage, significant oxidative reactions in both the lipids and proteins were observed with the increase in thiobarbituric acid reactive substances (TBARS) and carbonyls and decrease in sulphydryl groups and protein solubility...
January 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29352129/molecular-characterization-of-the-grape-seeds-extract-s-effect-against-chemically-induced-liver-cancer-in-vivo-and-in-vitro-analyses
#17
Alaaeldin Ahmed Hamza, Gehan Hussein Heeba, Hanan Mohamed Elwy, Chandraprabha Murali, Raafat El-Awady, Amr Amin
The purpose of this study was to investigate the anti-cancer property of grape seed extract (GSE) during early stages of developing liver cancer using a two-stage carcinogenic model combining diethylnitrosamine (DEN) and 2-Acetyl Aminofluorene (2-AAF). Administration of GSE at doses 25, 50 and 100 mg/kg per day started at the beginning of promotion periods and continued for 14 weeks. GSE dramatically inhibited pre-neoplastic foci formation as well as significantly decreased the number and the area of placental glutathione-S-transferase in livers of DEN-2AAF-treated rats by approximately 4 & 10 fold deductions, respectively...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29349878/efficacy-of-grape-seed-extract-gel-in-the-treatment-of-chronic-periodontitis-a-randomized-clinical-study
#18
Mohammad Rayyan, Tammam Terkawi, Hajer Abdo, Dalia Abdel Azim, Aseel Khalaf, Zenab AlKhouli, Maha Meziad, Marwa Alshamma'a, Horiyah Abu Naim
AIM: The aim of the present study was to assess the effectiveness of applying grape seed extract (GSE) gel in periodontal pockets for the treatment of chronic periodontitis. METHODS: Eighty-six sites with pocket depth (PD) >4 mm were selected from five systemically-healthy patients in whom scaling, and root planing were performed, and oral instructions were given, a week earlier. PD, gingival index (GI), plaque index (PI), and bleeding on probing (BOP) were measured, and sites were then divided into the control group (N = 38) and GSE group (N = 48)...
January 18, 2018: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/29279544/use-of-grape-seed-extract-for-improving-the-shear-bond-strength-of-total-etching-adhesive-to-bleached-enamel
#19
Yingxin Xu, Jianfeng Zhou, Jianguo Tan
This study was to ascertain if grape seed extract (GSE) can restore the shear bond strength (SBS) of total-etching adhesive to enamel immediately after bleaching. Immediately after bleaching with Beyond gel, different concentrations of GSE were applied to the surface of bovine enamel for 1 min before bonding of resin composite with Adper single bond 2 or All-Bond 3 adhesive. SBS values and debonding modes were recorded. Structure of the bonding interface and elements on enamel surface were analyzed by scanning electron microscopy and X-ray photoelectron spectroscopy (XPS)...
March 30, 2018: Dental Materials Journal
https://www.readbyqxmd.com/read/29223045/investigation-of-antioxidant-ability-of-grape-seeds-extract-to-prevent-oxidatively-induced-dna-damage-by-gas-chromatography-tandem-mass-spectrometry
#20
Önder Aybastıer, Sam Dawbaa, Cevdet Demir
Phenolic compounds have been studied elaborately for their efficacy to improve health and to protect against a wide variety of diseases. Herein this study, different analysis methods were implemented to evaluate the antioxidant properties of catechin and cyanidin using their standard substances and as they found in the grape seeds extracts. Total phenol contents were 107.39±8.94mg GAE/g dw of grape seeds for grape seed extract (GSE) and 218.32±10.66mg GAE/g dw of grape seeds for acid-hydrolyzed grape seed extract (AcGSE)...
January 1, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
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