keyword
MENU ▼
Read by QxMD icon Read
search

"Grape seed extract"

keyword
https://www.readbyqxmd.com/read/28903761/protective-effects-of-grape-seed-and-skin-extract-against-high-fat-diet-induced-lipotoxicity-in-rat-lung
#1
Mohamed El Ayed, Safwen Kadri, Selima Smine, Salem Elkahoui, Ferid Limam, Ezzedine Aouani
BACKGROUND: Obesity is a public health problem characterized by increased fat accumulation in different tissues. Obesity is directly linked to breathing problems and medical complications with lung, including obstructive sleep apnea syndrome, obesity hypoventilation syndrome, chronic obstructive pulmonary disease, asthma….In the present work, we aimed to investigate the effect of high fat diet (HFD) on lung lipotoxicity, oxidative stress, fatty acid composition and proportions in lung and implication in asthma development...
September 13, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28881609/grape-seed-extracts-modify-the-outcome-of-oxaliplatin-in-colon-cancer-cells-by-interfering-with-cellular-mechanisms-of-drug-cytotoxicity
#2
Letizia Porcelli, Rosa Maria Iacobazzi, Anna Elisa Quatrale, Carlo Bergamini, Nunzio Denora, Pasquale Crupi, Donato Antonacci, Anita Mangia, Giovanni Simone, Nicola Silvestris, Amalia Azzariti
Grape seed extracts are commonly utilized as dietary supplements for their antioxidant properties, even from cancer patients. However, whether these natural extracts interfere with chemotherapeutics utilized in colon cancer treatment is still poorly investigated. The cytotoxicity of extracts from Italia and Palieri cultivars either alone or in combination with oxaliplatin was evaluated in colon cancer cells. Grape seed extracts displayed anti-proliferative activity depending on the concentration utilized through apoptosis induction...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28877280/mechanical-properties-water-sorption-characteristics-and-compound-release-of-grape-seed-extract-incorporated-resins
#3
Don Jeevanie Epasinghe, Cynthia Kar Yung Yiu, Michael Francis Burrow
Objective: This study evaluated the effect of grape seed extract (GSE) incorporation on the mechanical properties, water sorption, solubility, and GSE release from the experimental adhesive resins. Material and Methods: An experimental comonomer mixture, consisting of 40% Bis-GMA, 30% Bis MP, 28% HEMA, 0.26% camphorquinone and 1% EDMAB, was used to prepare four GSE-incorporated adhesive resins at concentrations of 0.5, 1, 1.5, and 2 wt%. The neat resin without GSE was used as the control...
July 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28876465/procyanidin-b2-3-3-di-o-gallate-induces-oxidative-stress-mediated-cell-death-in-prostate-cancer-cells-via-inhibiting-map-kinase-phosphatase-activity-and-activating-erk1-2-and-ampk
#4
Rahul Kumar, Gagan Deep, Michael F Wempe, Joseph Surek, Amit Kumar, Rajesh Agarwal, Chapla Agarwal
Neoplastic cells exhibit higher oxidative stress compared to normal cells; however, antioxidants based clinical trials have mostly failed. Another attractive therapeutic approach is to further increase the oxidative stress in cancer cells leading to cell death. Herein, we show that Procyanidin B2 3,3"-di-O-gallate (B2G2), the most active constituent of grape seed extract, treatment causes cell death in human prostate cancer (PCa) cells (LNCaP and 22Rv1) via increasing the reactive oxygen species (ROS) generation...
September 6, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28875188/alterations-to-metabolically-active-bacteria-in-the-mucosa-of-the-small-intestine-predict-anti-obesity-and-anti-diabetic-activities-of-grape-seed-extract-in-mice
#5
Laura E Griffin, Katherine A Witrick, Courtney Klotz, Melanie R Dorenkott, Katheryn M Goodrich, Gabrielle Fundaro, Ryan P McMillan, Matthew W Hulver, Monica A Ponder, Andrew P Neilson
Epidemiological and clinical studies suggest that grapes and grape-derived products may reduce the risk for chronic disease. Grape seed extract specifically has been gaining interest due to its reported ability to prevent weight gain, moderate hyperglycemia, and reduce inflammation. The purpose of this study was to examine the long-term effects of two doses of grape seed extract (10 and 100 mg kg(-1) body wt per d in mice) on markers of metabolic syndrome in the context of a moderately high-fat diet. After 12 weeks, the lower dose of grape seed extract was more effective at inhibiting fat gain and improving glucose tolerance and insulin sensitivity...
September 6, 2017: Food & Function
https://www.readbyqxmd.com/read/28868839/effect-of-grape-seed-extract-on-lipid-profile-and-expression-of-interleukin-6-in-polycystic-ovarian-syndrome-wistar-rat-model
#6
Zohreh Salmabadi, Homa Mohseni Kouchesfahani, Kazem Parivar, Latifeh Karimzadeh
Background: Polycystic ovary syndrome (PCOS) is a common but complex endocrine disorder and is the major cause of anovulation and consequent subfertility. In this study the effect of grape seed extract (GSE) on triglyceride (TG), total cholesterol (TC), highdensity lipoprotein-cholestrol (HDL-C), low-density lipoprotein-cholestrol (LDL-C) and interleukin-6 (IL-6) in PCOS Wistar rats were assessed. MATERIALS AND METHODS: In this experimental study, 84 adult female Wistar rats were divided into 7 groups (n=12) including control (intact), Sham (estradiol valerate solvent injection), control PCOS and 4 experimental PCOS groups...
October 2017: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/28855760/comparative-evaluation-of-chlorhexidine-grape-seed-extract-riboflavin-chitosan-modification-on-microtensile-bond-strength-of-composite-resin-to-dentin-after-polymerase-chain-reaction-thermocycling-an-in-vitro-study
#7
Rani Samyukta Gajjela, R Kalyan Satish, Girija S Sajjan, K Madhu Varma, T Rambabu, B H Vijaya Lakshmi
AIM: The purpose of this study was to evaluate the influence of chlorhexidine (CHX), grape seed extract (GSE), riboflavin/chitosan modification on microtensile bond strength (μTBS) of composite resin to dentin after polymerase chain reaction (PCR) thermocycling. MATERIALS AND METHODS: Forty extracted human molars were used and a flat surface was then prepared by removing the occlusal one-third. The teeth were randomly assigned into four groups - Group I in which self-etch adhesive (Adper Easy One) was applied and Groups II, III, IV were pretreated with 2% CHX, 6...
March 2017: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/28819809/effect-of-synthetic-and-natural-derived-novel-endodontic-irrigant-solutions-on-mechanical-properties-of-human-dentin
#8
Doglas Cecchin, Vitória Soares Giaretta, Bérove Granella Cadorin, Matheus Albino Souza, Cristina de Mattos Pimenta Vidal, Ana Paula Farina
This study aimed to evaluate the effects of different synthetic and natural-derived root canal irrigants (6% sodium hypochlorite [NaOCl], 6% calcium hypochlorite [Ca(OCl)2] and 6.5% grape seed extract [GSE]) on dentin mechanical properties (flexural strength, ultimate tensile strength [UTS] and fracture resistance). Rectangular-shaped beams and hourglass-shaped sections obtained from mid-coronal and root dentin were treated with 6% NaOCl, 6% Ca(OCl)2 or 6.5% GSE for 30 min. The irrigant solutions were replaced every 5 min...
August 17, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28760744/proanthocyanidin-trimer-gallate-modulates-lipid-deposition-and-fatty-acid-desaturation-in-caenorhabditis-elegans
#9
Yu Nie, Brad Littleton, Thomas Kavanagh, Vincenzo Abbate, Sukhvinder S Bansal, David Richards, Peter Hylands, Stephen R Stürzenbaum
The incidence of obesity is rising at an alarming rate. Despite its recognition as an urgent healthcare concern, obesity remains largely an unsolved medical problem. A comprehensive screen for functional dietary phytochemicals identified proanthocyanidins as putative targets to ameliorate obesity. A full-scale purification of oligomeric proanthocyanidins (OPCs) derived from grape seed extract, yielded pure OPC dimer, trimer, tetramer, and their gallates (pOPCs). Forward chemical screening conducted in Caenorhabditis elegans suggested that pOPCs reduced the activity of lipase in vitro and triglyceride storage capacity in vivo Proanthocyanidin trimer gallate in particular modified lipid desaturation in C...
July 31, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28751073/efficacy-of-new-natural-biomodification-agents-from-anacardiaceae-extracts-on-dentin-collagen-cross-linking
#10
M A Moreira, N O Souza, R S Sousa, D Q Freitas, M V Lemos, D M De Paula, F J N Maia, D Lomonaco, S E Mazzetto, V P Feitosa
OBJECTIVES: Several polyphenols from renewable sources were surveyed for dentin biomodification. However, phenols from cashew nut shell liquid (CNSL, Anacardium occidentale) and from Aroeira (Myracrodruon urundeuva) extract have never been evaluated. The present investigation aimed to compare the dentin collagen crosslinking (biomodification) effectiveness of polyphenols from Aroeira stem bark extract, proanthocyanidins (PACs) from grape-seed extract (Vitis vinifera), cardol and cardanol from CNSL after clinically relevant treatment for one minute...
July 24, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28687392/characterization-and-in-vitro-anticancer-properties-of-chitosan-microencapsulated-flavan-3-ols-rich-grape-seed-extracts
#11
Michelangelo Iannone, Rosario Mare, Donatella Paolino, Agnese Gagliardi, Francesca Froiio, Donato Cosco, Massimo Fresta
Studies have fully demonstrated that a diet rich in fruit and vegetables may reduce the incidence of tumors. In particular, Grape Seed Extract (GSE) has been shown to carry on chemopreventive and antitumor activity thanks to the numerous beneficial substances it contains. The purpose of this work was to create a biocompatible matrix containing GSE in order to obtain microparticles able to modulate its biopharmaceutical parameters. The spray-drying technique was chosen in order to realize chitosan microparticles characterized by a mean diameter of 4-10μm and a positive surface charge that decreased after GSE encapsulation...
November 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28654207/the-effect-of-obesity-and-repeated-exposure-on-pharmacokinetic-response-to-grape-polyphenols-in-humans
#12
Janet A Novotny, Tzu-Ying Chen, Anton I Terekhov, Sarah K Gebauer, David J Baer, Lap Ho, Giulio M Pasinetti, Mario G Ferruzzi
SCOPE: Evidence suggests that dietary pattern may affect polyphenol absorption and/or metabolism. Further, obesity is associated with lower circulating nutrients, though the reason is unclear. We investigated the pharmacokinetic (PK) response of polyphenols in obese/overweight vs. lean individuals before and after repeated dosing with of grape polyphenols. METHODS AND RESULTS: A pilot study was conducted in which PK challenges were administered before and after 11 days of repeated dosing with polyphenols...
June 27, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28629290/functional-foods-how-functional-are-they-a-case-report-of-supplement-induced-psychosis
#13
Priyanka Yadav, Kyle Stigall, Hannah E Johnson, Abner O Rayapati, Nitin Chopra
There is rising evidence of patients' use of alternative and complementary medicine. The percentage of the U.S. population who used at least one dietary supplement increased from 42% in 1988-1994 to 53% in 2003-2006. We present a case of an Asian female in her 40s, with no previous psychiatric illness, who presented to the emergency room following a brief psychotic episode, during which she self-amputated the tips of her fingers, after using multivitamins and herbal supplements including ginseng, gui yuan rou (Chinese herb), astaxanthin, goji (Chinese fruit), selenium, saw palmetto, grape seed extract, citrus bioflavanoid, lutein (zeaxantin), resvexatrol, sun chlorella, spirulina powder, phytoceramides, phytoestrogen, glucosatrin, bromelain plus, and American bee pollen...
August 2016: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/28587960/mathematical-modeling-of-gallic-acid-release-from-chitosan-films-with-grape-seed-extract-and-carvacrol
#14
Javiera F Rubilar, Rui M S Cruz, Rommy N Zuñiga, Igor Khmelinskii, Margarida C Vieira
Controlled release of antimicrobial and antioxidant compounds from packaging films is of utmost importance for extending the shelf-life of perishable foods. This study focused on the mathematical modeling of gallic acid release into an aqueous medium from three chitosan films, formulated with grape seed extract (GSE) and carvacrol. We quantified the release by HPLC technique during 30days at three temperatures (5, 25 and 45°C). The diffusion coefficients, varying with temperature according to an Arrhenius-type relationship, and the respective activation energies for Film-1 and Film-2 were, respectively [Formula: see text] m(2)s(-1) and [Formula: see text] m(2)s(-1), Ea1=58kJmol(-1) and Ea2=60kJmol(-1) as obtained from the Fickian fit...
November 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28578061/effects-of-the-combination-of-%C3%AF-3-pufas-and-proanthocyanidins-on-the-gut-microbiota-of-healthy-rats
#15
Sara Ramos-Romero, Mercè Hereu, Eunice Molinar-Toribio, María Pilar Almajano, Lucía Méndez, Isabel Medina, Núria Taltavull, Marta Romeu, Maria Rosa Nogués, Josep Lluís Torres
ω-3 Polyunsaturated fatty acids (PUFAs) reduce risk factors for cardiovascular diseases (CVD) and other pathologies that involve low-grade inflammation. They have recently been shown to exert complementary functional effects with proanthocyanidins. As the reduction of health-promoting gut bacteria such as lactobacilli and bifidobacteria has been linked to a number of alterations in the host, the aim of this study was to determine whether PUFAs and proanthocyanidins also cooperate in maintaining well-balanced microbiota...
July 2017: Food Research International
https://www.readbyqxmd.com/read/28578033/influence-of-omega-3-pufas-on-the-metabolism-of-proanthocyanidins-in-rats
#16
Eunice Molinar-Toribio, Sara Ramos-Romero, Elisabet Fuguet, Núria Taltavull, Lucía Méndez, Marta Romeu, Isabel Medina, Josep Lluís Torres, Jara Pérez-Jiménez
Studies of the bioavailability of proanthocyanidins usually consider them independently of other dietary constituents, while there is a tendency in the field of functional foods towards the combination of different bioactive compounds in a single product. This study examined the long-term effects of ω-3 polyunsaturated fatty acids of marine origin on the metabolic fate of grape proanthocyanidins. For this, female adult Wistar-Kyoto rats were fed (18weeks) with a standard diet supplemented or not with eicosapentaenoic acid/docosahexaenoic acid (1:1, 16...
July 2017: Food Research International
https://www.readbyqxmd.com/read/28568316/influence-of-diabetes-on-plasma-pharmacokinetics-and-brain-bioavailability-of-grape-polyphenols-and-their-phase-ii-metabolites-in-the-zucker-diabetic-fatty-rat
#17
Tzu-Ying Chen, Mario G Ferruzzi, Qing-Li Wu, James E Simon, Stephen T Talcott, Jun Wang, Lap Ho, George Todd, Bruce Cooper, Giulio M Pasinetti, Elsa M Janle
SCOPE: The effect of diabetes on the pharmacokinetics, bioavailability and brain distribution of grape polyphenols and select metabolites was studied in the Zucker diabetic fatty (ZDF) rat model. METHODS AND RESULTS: (ZDF) rats and their lean controls (LN) were dosed with a Standardized Grape Polyphenol (SGP) Mixture consisting of grape seed extract, Concord grape juice and resveratrol (RES) by oral gavage for 10 days. An 8 hour pharmacokinetic study was performed...
June 1, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28507011/influence-of-diet-in-multiple-sclerosis-a-systematic-review
#18
REVIEW
M José Bagur, M Antonia Murcia, Antonia M Jiménez-Monreal, Josep A Tur, M Mar Bibiloni, Gonzalo L Alonso, Magdalena Martínez-Tomé
Nutrition is considered to be a possible factor in the pathogenesis of the neurological disease multiple sclerosis (MS). Nutrition intervention studies suggest that diet may be considered as a complementary treatment to control the progression of the disease; a systematic review of the literature on the influence of diet on MS was therefore conducted. The literature search was conducted by using Medlars Online International Literature (MEDLINE) via PubMed and Scopus. Forty-seven articles met the inclusion criteria...
May 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28471235/mechanism-of-grape-seeds-extract-protection-against-paracetamol-renal-cortical-damage-in-male-albino-rats
#19
S M N Abdel-Hafez, R A Rifaai, W Y Abd Elzaher
OBJECTIVE: The aim of the study was to assess the possible protective role of grape seeds extract (GSE) in ameliorating the toxic effects of paracetamol overdose on the rat renal cortical tissue. BACKGROUND: Paracetamol is one of the widely used non-steroidal anti-inflammatory drugs (NSAIDs). Unfortunately, it was reported as the most common cause of toxic ingestion in the world. Grape seeds extract (GSE) is known to have a strong antioxidant and anti-inflammatory properties...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28403352/effects-of-grape-seed-extract-on-periodontal-disease-an-experimental-study-in-rats
#20
Feyza Otan Özden, Elif Eser Sakallioğlu, Umur Sakallioğlu, Bülent Ayas, Züleyha Erişgin
Objective: This study aimed to demonstrate the effect of grape seed extract (GSE) on periodontitis. Material and Methods: Ligature induced periodontitis was created in 40 rats and they were assigned to four equal groups. One group was fed laboratory diet (group A) while three groups received GSE additionally. Silk ligatures were placed around the cervical area of the mandibular first molars for four weeks to induce periodontitis. The GSE groups were reallocated regarding GSE consumption as: for two weeks before ligation (group B; totally eight weeks), from ligation to two weeks after removal of the ligature (group C; totally six weeks), and for two weeks from ligature removal (group D; totally two weeks)...
March 2017: Journal of Applied Oral Science: Revista FOB
keyword
keyword
115125
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"