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"Grape seed extract"

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https://www.readbyqxmd.com/read/27892838/effect-of-bioactive-primers-on-bacterial-induced-secondary-caries-at-the-tooth-resin-interface
#1
G E Kim, A A Leme-Kraus, R Phansalkar, G Viana, C Wu, S-N Chen, G F Pauli, Akb Bedran-Russo
Secondary caries at the tooth-resin interface is the primary reason for replacement of resin composite restorations. The tooth-resin interface is formed by the interlocking of resin material with hydroxyapatite crystals in enamel and collagen mesh structure in dentin. Efforts to strengthen the tooth-resin interface have identified chemical agents with dentin collagen cross-linking potential and antimicrobial activities. The purpose of the present study was to assess protective effects of bioactive primer against secondary caries development around enamel and dentin margins of class V restorations, using an in vitro bacterial caries model...
November 28, 2016: Operative Dentistry
https://www.readbyqxmd.com/read/27891467/an-in-vitro-comparative-study-of-shear-bond-strength-of-composite-resin-to-bleached-enamel-using-three-herbal-antioxidants
#2
Pratap Kumar Mukka, Nanda Kumar Komineni, Sambashivarao Pola, E Soujanya, Anand Ramtheerth Karne, Bhasker Nenavath, Sandeep Shiva, Pallavi Vuppunuthula
INTRODUCTION: If adhesive restorations are carried out imme-diately, the Shear Bond Strength (SBS) to bleached enamel is reduced. The use of antioxidants can be highlighted since it seems to be a more effective alternative to reduce or remove the residual oxygen and immediate improvement in SBS. AIM: The purpose of this in-vitro study was an attempt to regain the lost bond strength, for which, the comparison of SBS of composite resin to bleached enamel was carried out using various antioxidants i...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27889390/safety-assessment-of-4-week-oral-intake-of-proanthocyanidin-rich-grape-seed-extract-in-healthy-subjects
#3
Atsushi Sano
A clinical study was conducted to assess the safety and tolerability of oral doses of proanthocyanidin-rich grape seed extract (GSE) in healthy Japanese adult volunteers. In an open-label, 4-week toxicity test, 29 subjects daily received 1,000, 1,500, or 2,500 mg GSE orally. Serum Fe levels of two subjects in the 2,500 mg GSE group decreased to 61 and 60 μg/100 mL from 205 and 182 μg/100 mL at baseline respectively, at second week of GSE consumption; these values are low but within the normal range for the Japanese population...
November 23, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27873332/monitoring-of-compositional-changes-during-berry-ripening-in-grape-seed-extracts-of-cv-sangiovese-vitis-vinifera-l
#4
Giuseppe Bombai, Federica Pasini, Vito Verardo, Onur Sevindik, Michele Di Foggia, Paola Tessarin, Anna Maria Bregoli, Paola Taddei, Maria Fiorenza Caboni, Adamo Domenico Rombolà
BACKGROUND: Seed oil and flours have been attracting the interest of researchers and industry, since they contain various bioactive components. We monitored the effects of ripening on lipids, flavan-3-ols, proanthocyanidins and tocols concentration in seed extracts from organically-cultivated cv. Sangiovese vines. RESULTS: Linoleic acid was the most abundant fatty acid, followed by oleic, palmitic and stearic acids. The tocols detected were α-tocopherol, α-tocotrienol and γ-tocotrienol...
November 21, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27866000/effectiveness-of-final-decontamination-protocols-against-enterococcus-faecalis-and-its-influence-on-bond-strength-of-filling-material-to-root-canal-dentin
#5
Matheus Albino Souza, Daniel Dalla Lana, Ezequiel Gabrielli, Marlos Barbosa Ribeiro, Daniela Cristina Miyagaki, Doglas Cecchin
AIM: The aim of this study was to evaluate the effectiveness of final decontamination protocols against Enterococcus faecalis and their influence on bond strength of filling material to root canal dentin. MATERIAL AND METHODS: Ninety root canals were enlarged with ProTaper system and inoculated with E. faecalis for 15 days. Sixty samples were randomly divided into six groups (n=10) and subjected to following protocols: G1-distilled water(control), G2-2% chlorhexidine, G3-QMix, G4-6...
November 16, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27859814/black-rhinoceros-diceros-bicornis-and-domestic-horse-equus-caballus-hindgut-microflora-demonstrate-similar-fermentation-responses-to-grape-seed-extract-supplementation-in%C3%A2-vitro
#6
N F Huntley, H D Naumann, A L Kenny, M S Kerley
The domestic horse is used as a nutritional model for rhinoceros maintained under human care. The validity of this model for browsing rhinoceros has been questioned due to high prevalence of iron overload disorder (IOD) in captive black rhinoceros (Diceros bicornis), which is associated with high morbidity and mortality. Iron chelators, such as tannins, are under investigation as dietary supplements to ameliorate or prevent IOD in prone species. Polyphenolic compounds variably affect microbial fermentation, so the first objective of this experiment was to evaluate the effects of grape seed extract (GSE; a concentrated source of condensed tannins; CT) on black rhinoceros hindgut fermentation...
November 13, 2016: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/27843246/evaluation-and-comparison-of-the-antibacterial-activity-against-streptococcus-mutans-of-grape-seed-extract-at-different-concentrations-with-chlorhexidine-gluconate-an-in-vitro-study
#7
REVIEW
Milan Swadas, Bhavna Dave, Soham M Vyas, Nupur Shah
INTRODUCTION: Streptococcus mutans has been implicated as primary microorganisms which cause dental caries in humans. There has been an increased interest in the therapeutic properties of some medicinal plants and natural compounds which have demonstrated antibacterial activities. Grape is one of the plants of this group which contains tannin and polyphenolic compound. AIM: To evaluate and compare antibacterial activity of grape seed extract at different concentrations with chlorhexidine gluconate against S...
July 2016: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/27822171/grape-seed-powder-improves-renal-failure-of-chronic-kidney-disease-patients
#8
Khaoula Turki, Kamel Charradi, Habib Boukhalfa, Monia Belhaj, Ferid Limam, Ezzedine Aouani
Chronic kidney disease (CKD) is a syndrome characterized by progressive and irreversible deterioration of renal function linked to slow destruction of renal parenchyma, eventually terminating in death when sufficient number of nephrons are damaged. Oxidative stress is commonly observed in CKD patients resulting from an imbalance between overproduction of reactive oxygen species (ROS) and impairment of defence mechanisms. Grape seed extract (GSE) is a polyphenolic mixture exhibiting antioxidant and anti-inflammatory properties...
2016: EXCLI journal
https://www.readbyqxmd.com/read/27813697/radioprotective-effect-of-green-tea-and-grape-seed-extracts-mixture-on-gamma-irradiation-induced-immune-suppression-in-male-albino-rats
#9
W El-Desouky, A H Mahmoud, M M Abbas
: Green tea extract (GTE) and grape seed extract (GSE) have antioxidant and radioprotective effects. The current study aimed to investigate the radioprotective effect of GTE and GSE mixture on radiation induced immune suppression in rats. METHOD: 35 male albino rats were divided into five groups: group 1 (control rats). The 2(nd) and 3(rd) groups rats were exposed to a single dose of gamma radiation (5 and 10Gy) respectively. The 4(th) and 5(th) groups of rats were gamma irradiated with 5 and 10Gy respectively, then administrated by gavage with GTE and GSE mixture (100 mg: 200 mg/kg B...
November 4, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27808339/differentiated-caco-2-cell-monolayers-exhibit-adaptation-in-the-transport-and-metabolism-of-flavan-3-ols-with-chronic-exposure-to-both-isolated-flavan-3-ols-and-enriched-extracts
#10
Benjamin W Redan, Mohammad Chegeni, Mario G Ferruzzi
The relatively low oral bioavailability of flavan-3-ols from acute doses is commonly highlighted as a limitation when considering the biological significance of these compounds. However, evidence suggests that the absorption of flavan-3-ols may be enhanced during periods of repeated exposure which is more representative of dietary patterns. To explore changes occurring in the upper small intestine from repeated exposure to dietary flavan-3-ols, Caco-2 human intestinal cells were cultured and differentiated in the presence of isolated flavan-3-ols epigallocatechin gallate (EGCG) and epicatechin (EC) or flavan-3-ol-rich green tea and grape seed extracts...
November 3, 2016: Food & Function
https://www.readbyqxmd.com/read/27804907/effect-of-dietary-supplementation-of-grape-seed-extract-on-the-growth-performance-lipid-profile-antioxidant-status-and-immune-response-of-broiler-chickens
#11
M H Farahat, F M Abdallah, H A Ali, A Hernandez-Santana
Grape seed extracts (GSE) contain several beneficial bioactive constituents; therefore, can be utilized as a potential feed additive in broiler chickens. An experiment was conducted to investigate the effect of supplementation of broiler chicken diets with GSE as a natural antioxidant at levels of 125, 250, 500, 1000 and 2000 ppm on the growth performance, serum lipid profile, liver glutathione-reduced, thigh muscle malondialdehyde and humoral immune response against Newcastle disease virus vaccines. This experiment was performed during the life-span of chickens from 0 to 42 days of age...
November 2, 2016: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/27799805/clinical-effects-of-an-oral-supplement-rich-in-antioxidants-on-skin-radiance-in-women
#12
Marion Dumoulin, David Gaudout, Benoit Lemaire
BACKGROUND: Environmental factors impact the skin aging resulting in decrease of skin radiance. Nutrition and particularly antioxidants could help to fight against skin degradation. OBJECTIVE: The aim of this study was to evaluate the effects of an oral supplement rich in specific antioxidants, SkinAx(2TM), on the improvement of the skin radiance in women. METHODS: The open-label clinical study enrolled 35 women, aged 40-70, with facial dull complexion...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27766227/cardioprotective-effect-of-grape-seed-extract-on-chronic-doxorubicin-induced-cardiac-toxicity-in-wistar-rats
#13
Nasser Razmaraii, Hossein Babaei, Alireza Mohajjel Nayebi, Gholamreza Assadnassab, Javad Ashrafi Helan, Yadollah Azarmi
Purpose: The aim of the present study was to determine the ability of grape seed extract (GSE) as a powerful antioxidant in preventing adverse effect of doxorubicin (DOX) on heart function. Methods: Male rats were divided into three groups: control, DOX (2 mg/kg/48h, for 12 days) and GSE (100 mg/kg/24h, for 16 days) plus DOX. Left ventricular (LV) function and hemodynamic parameters were assessed using echocardiography, electrocardiography and a Millar pressure catheter. Histopathological analysis and in vitro antitumor activity were also evaluated...
September 2016: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27759892/the-photostabilizing-effect-of-grape-seed-extract-on-three-common-sunscreen-absorbers
#14
Bice S Martincigh, Moses A Ollengo
The photostabilizing ability of grape seed extract on three common sunscreen absorbers, 2-ethylhexyl-p-methoxycinnamate (EHMC), benzophenone-3 (BP3) and tert-butylmethoxy dibenzoylmethane (BMDBM), was investigated. Samples were exposed to simulated solar radiation and monitored by spectrophotometric and chromatographic methods. The chemical composition of the grape seed extract was determined by GC-MS and HPLC-MS, and the major secondary metabolites were found to be epicatechin and catechin. Exposure of the extract to UV radiation increased the UV absorption capacity of the extract...
October 19, 2016: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/27745773/is-the-inactivation-of-dentin-proteases-by-crosslinkers-reversible
#15
Roda Seseogullari-Dirihan, Mustafa Murat Mutluay, David H Pashley, Arzu Tezvergil-Mutluay
OBJECTIVE: Inactivation of dentin proteases by crosslinkers has been suggested as a way to prevent the degradation of dentin collagen in the hybrid layer. However, it is not known if the inhibition is reversible. The aim of this study was to evaluate the inactivation effect of various crosslinkers on dentin protease activity over a period of 6 months. METHODS: Demineralized dentin beams (1×2×6mm, n=10/group) were treated with (1) 1% glutaraldehyde (GA1), (2) 5% glutaraldehyde (GA5), (3) 1% grape seed extract (GS1), (4) 5% grape seed extract (GS5), (5) 10% sumac berry extract (S), (6) 20μM curcumin (CR20), and (7) 200μM curcumin (CR200) for 5min...
October 10, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/27739110/anti-dermatophyte-and-anti-malassezia-activity-of-extracts-rich-in-polymeric-flavan-3-ols-obtained-from-vitis-vinifera-seeds
#16
Giovanna Simonetti, Felicia Diodata D'Auria, Nadia Mulinacci, Marzia Innocenti, Donato Antonacci, Letizia Angiolella, Anna Rita Santamaria, Alessio Valletta, Livia Donati, Gabriella Pasqua
Several human skin diseases are associated with fungi as dermatophytes and Malassezia. Skin mycoses are increasing and new alternatives to conventional treatments with improved efficacy and/or safety profiles are desirable. For the first time, the anti-dermatophytes and the anti-Malassezia activities of Vitis vinifera seed extracts obtained from different table and wine cultivars have been evaluated. Geometric minimal inhibitory concentration ranged from 20 to 97 µg/mL for dermatophytes and from 32 to 161 µg/mL for Malassezia furfur...
October 13, 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/27733040/reaction-of-acetaldehyde-with-wine-flavonoids-in-the-presence-of-sulfur-dioxide
#17
Marlena K Sheridan, Ryan J Elias
Acetaldehyde is responsible for many of the beneficial changes that occur in red wine as a result of oxidation. Ethylidene bridges are formed between flavonoids upon their reaction with acetaldehyde, which can contribute to improvements in color stability and SO2-resistant pigments. In the present study, the reactions between acetaldehyde and various flavonoids (catechin, tannins from grape seed extract, and malvidin-3-glucoside) were examined in a model wine system. Lower pH conditions were seen to significantly increase the rate of reaction with acetaldehyde while dissolved oxygen did not affect the rate...
October 13, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27730364/a-high-fat-high-sucrose-diet-affects-the-long-term-metabolic-fate-of-grape-proanthocyanidins-in-rats
#18
Eunice Molinar-Toribio, Elisabet Fuguet, Sara Ramos-Romero, Núria Taltavull, Lucía Méndez, M Rosa Nogués, Isabel Medina, Josep Lluís Torres, Jara Pérez-Jiménez
PURPOSE: Polyphenol metabolites are key mediators of the biological activities of polyphenols. This study aimed to evaluate the long-term effects of a high-fat high-sucrose (HFHS) diet on the metabolism of proanthocyanidins from grape seed extract (GSE). METHODS: Adult female Wistar-Kyoto rats were fed a standard (STD) or HFHS diet supplemented or not with GSE for 16 weeks. PA metabolites were determined by targeted HPLC-MS/MS analysis. RESULTS: A lower concentration of total microbial-derived PA metabolites was present in urine and the aqueous fraction of faeces in the HFHS + GSE group than in the STD + GSE group...
October 12, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/27640363/olive-and-grape-seed-extract-prevents-post-traumatic-osteoarthritis-damages-and-exhibits-in-vitro-anti-il-1%C3%AE-activities-before-and-after-oral-consumption
#19
Elsa Mével, Christophe Merceron, Claire Vinatier, Stéphanie Krisa, Tristan Richard, Martial Masson, Julie Lesoeur, Vincent Hivernaud, Olivier Gauthier, Jérôme Abadie, Geoffroy Nourissat, Xavier Houard, Yohann Wittrant, Nelly Urban, Laurent Beck, Jérôme Guicheux
Polyphenols exert a large range of beneficial effects in the prevention of age-related diseases. We sought to determine whether an extract of olive and grape seed standardized according to hydroxytyrosol (HT) and procyanidins (PCy) content, exerts preventive anti-osteoathritic effects. To this aim, we evaluated whether the HT/PCy mix could (i) have in vitro anti-inflammatory and chondroprotective actions, (ii) exert anti-osteoarthritis effects in two post-traumatic animal models and (iii) retain its bioactivity after oral administration...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27624317/rat-health-status-affects-bioavailability-target-tissue-levels-and-bioactivity-of-grape-seed-flavanols
#20
Maria Margalef, Zara Pons, Lisard Iglesias-Carres, Mar Quiñones, Francisca Isabel Bravo, Anna Arola-Arnal, Begoña Muguerza
SCOPE: Studying the flavanol metabolism is essential to identify bioactive compounds, as beneficial effects of flavanols have been attributed to their metabolic products. However, host-related factors, including pathological conditions, may affect flavanol metabolism and, thus, their bioactivity. This study aims to elucidate whether hypertension affects grape seed flavanol metabolism, influencing their bioactivity in relation to hypertension. MATERIALS AND RESULTS: Grape seed flavanols' effect on blood pressure (BP) was studied in spontaneously hypertensive rats (SHR) and healthy Wistar rats 6 h after grape seed extract administration (375 mg/kg)...
September 14, 2016: Molecular Nutrition & Food Research
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