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https://www.readbyqxmd.com/read/28934705/vitamin-c-the-next-step-in-sepsis-management
#1
REVIEW
J Teng, A Pourmand, M Mazer-Amirshahi
Sepsis is a life-threatening medical condition, affecting approximately 26 million people worldwide every year. The disease is a continuum, marked by dysregulated inflammation and hemodynamic instability leading to shock, multi-system organ dysfunction, and death. Over the past decades, there has been a focus on the early identification and treatment of sepsis primarily with bundled and goal directed therapy. Despite these advances, morbidity and mortality has remained high, prompting investigation into novel therapies...
September 18, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28933356/the-association-between-dietary-intake-of-antioxidants-and-ocular-disease
#2
Andrea Braakhuis, Ryan Raman, Ehsan Vaghefi
To assess the association between dietary antioxidant intake and the incidence of the three major oxidative stress-related eye diseases, cataracts, glaucoma, and age-related macular degeneration, 78 cases from the University of Auckland Optometry and Vision Science clinic and 149 controls were recruited. Participants completed an antioxidant food-frequency questionnaire, analysed through multiple logistic regression. Protective associations were identified with higher consumption of fruit and vegetables (OR = 0...
January 30, 2017: Diseases (Basel)
https://www.readbyqxmd.com/read/28929696/-clinical-analysis-of-cervus-and-cucumis-polypeptide-injection-based-on-real-world-hospital-information-system
#3
Shuai-Ling Sun, Yan-Ming Xie, Yuan-Yuan Li, Yin Zhang, Dan-Hui Yi, Yan Zhuang
To analyze the clinical application of Cervus and Cucumis Polypeptide injection in the real world, in order to define the characteristics of clinical drug use and correlation, and provide reference for risk management and further study for Cervus and Cucumis Polypeptide injection. Descriptive analysis and association rules analysis were performed on 37 721 cases using Cervus and Cucumis Polypeptide injection in 26 hospitals nationwide. Cervus and Cucumis Polypeptide injection were mostly adopted by patients aged between 45 and 64(39...
November 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28928511/color-bioactive-compounds-and-morphological-characteristics-of-encapsulated-asian-pear-juice-powder-during-spray-drying
#4
Chang-Gon Lee, Maruf Ahmed, Gui-Hun Jiang, Jong-Bang Eun
Encapsulated Asian pear juice powder was produced through spray drying using three maltodextrin levels (15, 20, and 25% w/v) and three inlet air temperatures (130, 150, and 170 °C). The impact of maltodextrin concentrations and inlet air temperatures on color, bioactive compounds, and morphological characteristics of encapsulated Asian pear juice powder were investigated. Maltodextrin concentrations and inlet air temperatures significantly influenced L(*) and b(*) values of encapsulated Asian pear juice powder...
August 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28928436/determination-of-quality-changes-in-peaches-wrapped-in-active-paper-and-stored-at-ambient-temperature-in-summer
#5
Xiao-Long Du, Hui Li, Wei-Hong Zhou, Ying Liu, Jian-Long Li
Peaches are known for their palatable flavor and abundant nutrients. However, peaches are perishable, and the existing preservation techniques for peaches are still immature. To further extend the shelf life and prevent nutrient loss of perishable peaches under ambient temperature in summer (approximately 25-32 °C), we conducted experiments wrapping peaches (Prunus persica cv 'Baihua') in single- and composite-treated vegetal fibrous papers that contained calcium carbonate, phytic acid, Na-alginate and vitamin C...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28927476/antioxidant-intake-from-diet-and-supplements-and-risk-of-digestive-cancers-in-middle-aged-adults-results-from-the-prospective-nutrinet-sant%C3%A3-cohort
#6
Manon Egnell, Philippine Fassier, Lucie Lécuyer, Rebeca Gonzalez, Laurent Zelek, Marie-Paule Vasson, Serge Hercberg, Paule Latino-Martel, Pilar Galan, Nathalie Druesne-Pecollo, Mélanie Deschasaux, Mathilde Touvier
Experimental studies suggest beneficial effects of antioxidants in digestive cancer prevention. However, epidemiological results are contrasting and few studies quantitatively assessed supplemental intake. This study aimed at investigating the associations between antioxidant intakes (dietary, supplemental and total) and digestive cancer risk. This prospective study included 38 812 middle-aged subjects (≥45 years) from the NutriNet-Santé cohort (2009-2016). Dietary data were collected using repeated 24 h records...
September 20, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28926854/telferia-occidentalis-and-vitamin-c-attenuate-phenylhydrazine-induced-haemolytic-anaemia-and-associated-cardio-renal-dysfunctions-via-inhibition-of-oxidative-stress-and-proapoptotic-protein-bax-expressions
#7
Temitayo Olabisi Ajibade, Ademola Adetokunbo Oyagbemi, Temidayo Olutayo Omobowale, Ebunoluwa Rachael Asenuga, Adebowale Bernard Saba
Background The study investigated the modulatory roles of the aqueous leaf extract of Telferia occidentalis, a traditional haematinic, and vitamin C on cardiovascular dysfunction associated with subchronic Phenylhydrazine exposure. Methods Fifty adult male rats were randomly selected and divided into one of five groups of ten animals each: Control; 40 mgkg(-1) Phenylhydrazine (PHZ); PHZ with 100 mgkg(-1) T.occidentalis; PHZ with 200 mgkg(-1) T.occidentalis; and PHZ with 100 mgkg(-1) vitamin C. Results Oral exposure of rats to PHZ, without T...
September 19, 2017: Drug Research
https://www.readbyqxmd.com/read/28926245/hno-is-produced-by-the-reaction-of-no-with-thiols
#8
Sebastian A Suarez, Martina Muñoz, Lucia Alvarez, Mateus F Venancio, Willian Rocha, Damian E Bikiel, Marcelo A Marti, Fabio Doctorovich
Azanone (nitroxyl, HNO) is a highly reactive compound whose biological role is still a matter of debate. One possible route for its formation is NO reduction by biological reductants. These reactions have been historically discarded due to the negative redox potential for the NO,H+/HNO couple. However, the NO to HNO conversion mediated by vitamins C, E and aromatic alcohols has been recently shown to be feasible from a chemical standpoint. Based on these precedents we decided to study the reaction of NO with thiols as potential sources of HNO...
September 19, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28925872/abdominal-aorta-aneurysm-aaa-is-there-a-role-for-prevention-and-therapy-using-antioxidants
#9
Joël Pincemail, Jean-Olivier Defraigne, Audrey Courtois, Adelin Albert, Jean-Paul Cheramy-Bien, Natzi Sakalihasan
Abdominal aortic aneurysm (AAA) is a degenerative disease that cause mortality in people aged > 65 years. Increased reactive oxygen species (ROS) and oxidative stress seems to play a pivotal role in AAA pathogenesis. Several sources of ROS have been identified in aortic tissues using experimental models: inflammation, increased activity of NAD(P)H or NOX, over-expression of inducible nitric oxide synthase (iNOS), uncoupled endothelial nitric oxide synthase (eNOS), platelets activation and iron release from hemoglobin...
September 18, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28923558/highly-selective-and-sensitive-sensor-based-on-an-organic-electrochemical-transistor-for-the-detection-of-ascorbic-acid
#10
Lijun Zhang, Guiheng Wang, Di Wu, Can Xiong, Lei Zheng, Yunsheng Ding, Hongbo Lu, Guobing Zhang, Longzhen Qiu
In this study, an organic electrochemical transistor sensor (OECT) with a molecularly imprinted polymer (MIP)-modified gate electrode was prepared for the detection of ascorbic acid (AA). The combination of the amplification function of an OECT and the selective specificity of MIPs afforded a highly sensitive, selective OECT sensor. Cyclic voltammetry and electrochemical impedance spectroscopy measurements were carried out to monitor the stepwise fabrication of the modified electrodes and the adsorption capacity of the MIP/Au electrodes...
September 7, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28922725/ameliorative-impact-of-morus-alba-leaves-aqueous-extract-against-embryonic-ophthalmic-tissue-malformation-in-streptozotocin-induced-diabetic-rats
#11
Adel M A Assiri, Mohamed E El-Beeh, Ali H Amin, Mohamed Fawzy Ramadan
BACKGROUND: Diabetes mellitus (DM) is becoming a serious threat to human health. Morus alba var. multicaulis (Perr.) Loudon (Moraceae) showed a bright future in DM therapy. OBJECTIVE: The study evaluates the antioxidant activity of Morus alba leaves aqueous extract (MLAE) and antidiabetic properties of MLAE in streptozotocin-induced diabetic rats focusing on the ameliorative effects against embryogenesis defects. MATERIALS AND METHODS: MLAE was assayed for bioactive compounds, and antiradical potential...
September 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28921575/ingested-nitrate-and-nitrite-disinfection-by-products-and-pancreatic-cancer-risk-in-postmenopausal-women
#12
Arbor J L Quist, Maki Inoue-Choi, Peter J Weyer, Kristin E Anderson, Kenneth P Cantor, Stuart Krasner, Laura E Beane Freeman, Mary H Ward, Rena R Jones
Nitrate and nitrite are precursors of N-nitroso compounds (NOC), probable human carcinogens that cause pancreatic tumors in animals. Disinfection by-products (DBP) exposures have also been linked with digestive system cancers, but few studies have evaluated relationships with pancreatic cancer. We investigated the association of pancreatic cancer with these drinking water contaminants and dietary nitrate/nitrite in a cohort of postmenopausal women in Iowa (1986-2011). We used historical monitoring and treatment data to estimate levels of long-term average nitrate and total trihalomethanes (TTHM; the sum of the most prevalent DBP class) and the duration exceeding one-half the maximum contaminant level (>½ MCL; nitrate-nitrogen 5mg/L, 40µg/L TTHM) among participants on public water supplies (PWS) >10 years...
September 16, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28920616/vitamin-c-protects-piglet-liver-against-zearalenone-induced-oxidative-stress-by-modulating-expression-of-nuclear-receptors-pxr-and-car-and-their-target-genes
#13
Baoming Shi, Yang Su, Siying Chang, Yuchen Sun, Xiangyu Meng, Anshan Shan
Zearalenone (ZEN), one of the most common mycotoxins found in human food and animal feed, has been shown to be effectively detoxified by vitamin C (Vc). The aim of this study was to investigate how vitamin C protects the piglet liver against oxidative stress induced by ZEN. A total of thirty-two healthy female crossbred weaning piglets (Duroc × Landrace × Large white) with an initial weight of 12.27 ± 0.30 kg were randomly divided into four treatment groups of eight piglets per group. The dietary treatments included two zearalenone levels (0 mg kg(-1) and 1...
September 18, 2017: Food & Function
https://www.readbyqxmd.com/read/28916963/effects-of-different-irrigation-practices-using-treated-wastewater-on-tomato-yields-quality-water-productivity-and-soil-and-fruit-mineral-contents
#14
Azize Dogan Demir, Ustun Sahin
Wastewater use in agricultural irrigation is becoming a common practice in order to meet the rising water demands in arid and semi-arid regions. The study was conducted to determine the effects of the full (FI), deficit (DI), and partial root-zone drying (PRD) irrigation practices using treated municipal wastewater (TWW) and freshwater (FW) on tomato yield, water use, fruit quality, and soil and fruit heavy metal concentrations. The TWW significantly increased marketable yield compared to the FW, as well as decreased water consumption...
September 15, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28912813/silicone-substrate-with-collagen-and-carbon-nanotubes-exposed-to-pulsed-current-for-msc-osteodifferentiation
#15
Daniyal Jamal, Roche C de Guzman
Autologous human adipose tissue-derived mesenchymal stem cells (MSCs) have the potential for clinical translation through their induction into osteoblasts for regeneration. Bone healing can be driven by biophysical stimulation using electricity for activating quiescent adult stem cells. It is hypothesized that application of electric current will enhance their osteogenic differentiation, and addition of conductive carbon nanotubes (CNTs) to the cell substrate will provide increased efficiency in current transmission...
2017: International Journal of Biomaterials
https://www.readbyqxmd.com/read/28912655/chronic-eccentric-exercise-and-antioxidant-supplementation-effects-on-lipid-profile-and-insulin-sensitivity
#16
Christina Yfanti, Athanasios Tsiokanos, Ioannis G Fatouros, Anastasios A Theodorou, Chariklia K Deli, Yiannis Koutedakis, Athanasios Z Jamurtas
Eccentric exercise has been shown to exert beneficial effects in both lipid profile and insulin sensitivity. Antioxidant supplementation during chronic exercise is controversial as it may prevent the physiological training-induced adaptations. The aim of this study was to investigate: 1) the minimum duration of the eccentric exercise training required before changes on metabolic parameters are observed and 2) whether antioxidant supplementation during training would interfere with these adaptations. Sixteen young healthy men were randomized into the Vit group (1 g of vitamin C and 400 IU vitamin E daily) and the placebo (PL) group...
September 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/28912361/impact-of-sleep-restriction-on-local-immune-response-and-skin-barrier-restoration-with-and-without-multi-nutrient-nutrition-intervention
#17
Tracey J Smith, Marques A Wilson, J Philip Karl, Jeb Orr, Carl D Smith, Adam D Cooper, Kristin J Heaton, Andrew J Young, Scott J Montain
Systemic immune function is impaired by sleep restriction. However, the impact of sleep restriction on local immune responses, and to what extent any impairment can be mitigated by nutritional supplementation is unknown. We assessed the effect of 72-h sleep restriction (2-h nightly sleep) on local immune function and skin barrier restoration of an experimental wound, and determined the influence of habitual protein intake (1.5 g·kg(-1)·d(-1)) supplemented with arginine, glutamine, zinc sulfate, vitamin C, vitamin D3 and omega-3 fatty acids compared to lower protein intake (0...
September 14, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28911645/antibiofilm-activity-of-cashew-juice-pulp-against-staphylococcus-aureus-high-performance-liquid-chromatography-diode-array-detection-and-gas-chromatography-mass-spectrometry-analyses-and-interference-on-antimicrobial-drugs
#18
Marcus V Dias-Souza, Renan M Dos Santos, Ezequias P de Siqueira, Pedro H Ferreira-Marçal
The epidemiology of Staphylococcus aureus infections has evolved in recent years, as this species is a major Gram-positive pathogen associated with healthcare services. The antimicrobial resistance of this species raises an urgent need for new treatment strategies. Fruits play important nutritional and economic roles in society, but their biological and pharmacological features are poorly explored when compared to nonedible parts of plants such as barks and leaves. In this study, we show that the cashew apple juice [cashew juice pulp (CJP)] extract is active against the planktonic cells of S...
July 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28905653/induction-of-cellular-and-molecular-immunomodulatory-pathways-by-vitamin-e-and-vitamin-c
#19
Joseph J Bivona, Sapna Patel, Michael Vajdy
Vitamins E and C are well known small molecules that have been used to maintain health for decades. Recent studies of the cellular and molecular pathways leading to immunomodulation by these molecules have been of interest, as have their anti-oxidant properties and signal transduction pathways for curing or improving infectious diseases and cancer. Areas covered: Herein, the authors provide a definition and the structural classification of vitamins E and C and how these molecules influence cellular function...
September 14, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28904739/role-of-oxidative-stress-and-mitochondrial-dysfunction-in-sepsis-and-potential-therapies
#20
REVIEW
Konstantinos Mantzarlis, Vasiliki Tsolaki, Epaminondas Zakynthinos
Sepsis is one of the most important causes of death in intensive care units. Despite the fact that sepsis pathogenesis remains obscure, there is increasing evidence that oxidants and antioxidants play a key role. The imbalance of the abovementioned substances in favor of oxidants is called oxidative stress, and it contributes to sepsis process. The most important consequences are vascular permeability impairment, decreased cardiac performance, and mitochondrial malfunction leading to impaired respiration. Nitric oxide is perhaps the most important and well-studied oxidant...
2017: Oxidative Medicine and Cellular Longevity
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