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"Vitamin c"

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https://www.readbyqxmd.com/read/28650324/formulation-evaluation-and-release-rate-characteristics-of-medicated-jelly-of-vitamin-c
#1
Khalid A Ibrahim, Asma Nawaz, Shamim Mumtaz, Furqan Muhammad Iqbal, Ahmad Khan, Shahiquz Zaman, Nasser M Abd El-Salam, Naseem Ullah, Tajamul Husain, Syed Nisar Hussain Shah
Medicated jelly formulations are patient friendly dosage form for pediatric, geriatric and dysphagic patients. These formulations offer rapid dissolution and absorption of drugs through oral mucosa therefore show the early onset of action. The objective of the study was to develop and evaluate oral jelly formulations of vitamin C. Slurry method was adopted using glucose 103gm, sugar 67gm, gelatin 10gm and sorbitol 6.56gm. Preformulation studies were performed including the organoleptic profile, pH, and solubility of both drugs...
March 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28643280/effect-of-oxidative-stress-from-nanoscale-tio2-particles-on-a-physarum-polycephalum-macroplasmodium-under-dark-conditions
#2
Zhi Zhang, Jianhua Zhang, Caixia Shi, Heng Guo, RuiYang Ni, Junle Qu, Jiaoning Tang, Shide Liu
Information regarding the effect of nanoscale titanium dioxide particles (nTiO2) on the environment under dark conditions is scarce, and the effect of nTiO2 on fungi is largely unknown. Due to its huge size and high sensitivity to external stimuli, the slime mold fungi cell, Physarum polycephalum macroplasmodium, was utilized as a novel subject for the toxicity investigations in the present study, and oxidative stress from nTiO2 on the macroplasmodium was assessed under dark conditions. Short exposure (2-3 h) caused an intracellular reactive oxygen species (ROS) imbalance, and an anti-oxidative mechanism was activated from intermediate doses of nTiO2 (5-18 mg/mL)...
June 22, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28642200/enhancement-of-solubility-and-dissolution-rate-of-baicalein-wogonin-and-oroxylin-a-extracted-from-radix-scutellariae
#3
Hang Yu, Jae-Sang Chang, Sun Young Kim, Yoon G Kim, Hoo-Kyun Choi
Baicalein, wogonin, and oroxylin A are three major hydrophobic components in the extract of Radix scutellariae with wide spectrum of pharmacological applications. The purpose of this study was to enhance the solubility, dissolution rate and stability of baicalein, wogonin and oroxylin A by solid dispersion (SD) technique. SD of the extract with various polymers was prepared to select the best carrier. Solubility study, chemical stability study and dissolution study were performed to characterize the SD. The solubility of all three components, after forming solid dispersion with povidone K-30 (PVP K-30) was significantly increased in pH 6...
June 19, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28639130/vitamin-c-improves-gastroparesis-in-diabetic-rats-effects-on-gastric-contractile-responses-and-oxidative-stress
#4
Luisa Mota Da Silva, Rita de Cássia Melo Vilhena de Andrade Fonseca da Silva, Daniele Maria-Ferreira, Olair Carlos Beltrame, José Eduardo da Silva-Santos, Maria Fernanda de Paula Werner
BACKGROUND: Diabetic gastroparesis is a common complication of diabetes mellitus, which mainly affects women. Previous studies have demonstrated that oxidative stress is involved in its onset and development. AIMS: This study evaluated the role of vitamin C on diabetes-associated gastric dysmotility. METHODS: Female rats with streptozotocin-induced diabetes were treated with vehicle (water, 1 mL/kg, p.o.), vitamin C (300 mg/kg/day, p.o.), or insulin (6 IU/day, s...
June 21, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28638434/an-evaluation-of-the-protective-role-of-vitamin-c-in-reactive-oxygen-species-induced-hepatotoxicity-due-to-hexavalent-chromium-in-vitro-and-in-vivo
#5
Xiali Zhong, Ming Zeng, Huanfeng Bian, Caigao Zhong, Fang Xiao
BACKGROUD: Drinking water contamination with hexavalent chromium [Cr (VI)] has become one of the most serious public health problems, thus the investigation of Cr (VI)-induced hepatotoxicity has attracted much attention in recent years. METHODS: In the present study, by determining the indices of hepatotoxicity induced by Cr (VI), the source of accumulated reactive oxygen species (ROS), and the protective effect of the antioxidant Vitamin C (Vit C), we explored the mechanisms involved in Cr (VI)-induced hepatotoxicity in vitro and in vivo...
2017: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/28634625/serum-antioxidant-capacity-biochemical-profile-and-body-composition-of-breast-cancer-survivors-in-a-randomized-mediterranean-dietary-intervention-study
#6
Maria Skouroliakou, D Grosomanidis, P Massara, C Kostara, P Papandreou, D Ntountaniotis, G Xepapadakis
PURPOSE: Increasing evidence suggests that Mediterranean Diet (MD) is correlated with reduced risk of breast cancer (BC) and cancer mortality, since it modifies patients' serum antioxidant capacity, body composition and biochemical parameters. The aim of the study was to investigate whether a dietary intervention based on MD has a beneficial effect on these factors. METHODS: In this intervention study, seventy female BC survivors were randomly assigned to (1) the intervention group (personalized dietary intervention based on MD) and (2) the control group (received the updated American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention and ad libitum diet)...
June 20, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28631923/influence-of-ingesting-a-flavonoid-rich-supplement-on-the-metabolome-and-concentration-of-urine-phenolics-in-overweight-obese-women
#7
David C Nieman, Sivapriya Ramamoorthy, Colin D Kay, Courtney L Goodman, Christopher R Capps, Zach L Shue, Nicole Heyl, Mary H Grace
This study evaluated the effect of ingesting a flavonoid-rich supplement (329 mg/d) on total urine phenolics and shifts in plasma metabolites in overweight/obese female adults using untargeted metabolomics procedures. Participants (N=103, 18-65 y, BMI ≥ 25 kg/m2) were randomized to flavonoid (F) or placebo (P) groups for 12 weeks, with blood and 24-h urine samples collected pre-study, 4- and 12-weeks in a parallel design. Supplements were prepared as chewable tablets, and included vitamin C, wild bilberry fruit extract, green tea leaf extract, quercetin, caffeine, and omega 3 fatty acids...
June 20, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28630807/an-overview-of-food-patterns-and-diet-quality-in-qatar-findings-from-the-national-household-income-expenditure-survey
#8
Mohammed Al-Thani, Al-Anoud Al-Thani, Nasser Al-Mahdi, Hefzi Al-Kareem, Darine Barakat, Walaa Al-Chetachi, Afaf Tawfik, Hammad Akram
INTRODUCTION: Availability of accurate data pertaining to a population's dietary patterns and associated health outcomes is critical for proper development and implementation of related policies. This article is a first attempt to share the food patterns, amounts and diet quality among households (HH) in Qatar. METHODS: Data from the 2012-2013 Qatar National Household Income and Expenditure Survey (HIES) was used. This cross-sectional survey included 3723 HH (1826 Qatari HH and 1897 non-Qatari HH)...
May 15, 2017: Curēus
https://www.readbyqxmd.com/read/28630693/quality-of-food-frequency-questionnaire-validation-studies-in-the-dietary-assessment-of-children-aged-12-to-36-months-a-systematic-literature-review
#9
REVIEW
Amy Lovell, Rhodi Bulloch, Clare R Wall, Cameron C Grant
A child's diet is an important determinant of growth and development. Because of this, the accurate assessment of dietary intake in young children remains a challenge. A systematic search of studies validating FFQ methodologies in children 12 to 36 months of age was completed. English-language articles published until March 2016 were searched using three electronic databases (MEDLINE, EMBASE and CINAHL). Quality assessment of the identified studies was carried out using The Reduced Summary Score and EURopean micronutrient RECommendations Aligned (EURRECA) scoring system...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/28627837/natural-antioxidant-vitamins-status-in-pregnancies-complicated-with-intrauterine-growth-restriction
#10
Amita K Gadhok, Tarun K Sharma, Maheep Sinha, Rakesh Khunteta, Satish K Vardey, Poonam Sahni, Manisha Sankhla
BACKGROUND: The weight of the infant at birth is a powerful predictor of infant growth and survival and is dependent on maternal health and nutrition during pregnancy. Pregnant women have a defense mechanism against increased oxidative stress composed of antioxidant enzymes and natural antioxidant vitamins like vitamin C and E. Therefore, we evaluated whether differences exist in serum levels of vitamin C and E in pregnant women complicated with intrauterine growth restriction (IUGR)...
May 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28626899/consideration-of-the-presence-of-inflammation-is-essential-for-interpretation-of-serum-micronutrient-results
#11
Emma Osland
It was with great interest I read the recent contribution by Christie-David and Gunton, 'Vitamin C deficiency and diabetes mellitus - easily missed?' [1], outlining their retrospective cohort study in 11 patients with poorly healing foot ulcers in the setting of diabetes mellitus. Their findings suggest previously unrecognized vitamin C deficiency may have been a contributing factor to the ulcers that were being treated in their clinic; a hypothesis supported by the healing reported to occur within 3 weeks of the commencement of vitamin C replacement [1]...
June 19, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28625733/new-grape-stems-isolated-phenolic-compounds-modulate-reactive-oxygen-species-glutathione-and-lipid-peroxidation-in-vitro-combined-formulations-with-vitamins-c-and-e
#12
Marcelo Queiroz, David Oppolzer, Irene Gouvinhas, Amélia M Silva, Ana I R N A Barros, Raúl Domínguez-Perles
The antioxidant potential of grape (Vitis vinífera L.) stems has been reported in the last decade although no identification of the individual compounds responsible for such action has been done. In this work, polyphenolic extract of grape stems was processed resorting to semi-preparative HPLC, allowing to obtain 5 purified polyphenols (caftaric acid, malvidin-3-O-glucoside, quercetin-3-O-glucuronide, mailvidin-3-O-(6-O-caffeoyl)-glucoside, and Σ-viniferin), which were fully characterized by HPLC-PDA-ESI-MS(n)...
June 16, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28623709/the-mechanism-of-neuroprotective-action-of-natural-compounds
#13
REVIEW
Agnieszka Wąsik, Lucyna Antkiewicz-Michaluk
Disturbance of cerebral redox homeostasis is the primary cause of human neurodegenerative disorders, such as Parkinson's disease or Alzheimer's disease. Well known experimental research demonstrates that oxidative stress is a main cause of cell death. A high concentration of reactive oxygen and nitrogen species leads to damage of a lot of proteins, lipids and also DNA. Synthetic compounds used for the treatment in the neurodegenerative diseases failed to meet the hopes they had raised and often exhibit a number of side effects...
April 30, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28622697/vitamin-c-and-doxycycline-a-synthetic-lethal-combination-therapy-targeting-metabolic-flexibility-in-cancer-stem-cells-cscs
#14
Ernestina Marianna De Francesco, Gloria Bonuccelli, Marcello Maggiolini, Federica Sotgia, Michael P Lisanti
Here, we developed a new synthetic lethal strategy for further optimizing the eradication of cancer stem cells (CSCs). Briefly, we show that chronic treatment with the FDA-approved antibiotic Doxycycline effectively reduces cellular respiration, by targeting mitochondrial protein translation. The expression of four mitochondrial DNA encoded proteins (MT-ND3, MT-CO2, MT-ATP6 and MT-ATP8) is suppressed, by up to 35-fold. This high selection pressure metabolically synchronizes the surviving cancer cell sub-population towards a predominantly glycolytic phenotype, resulting in metabolic inflexibility...
June 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28621940/on-the-solvation-and-proton-coupled-electron-transfer-reduction-potential-of-2-no-%C3%A2-to-1-hno-in-aqueous-solution-a-theoretical-investigation
#15
Mateus F Venancio, Fabio Doctorovich, Willian Ricardo Rocha
In this work quantum mechanical calculations and Monte Carlo statistical mechanical simulations were carried out to investigate the solvation properties of HNO in aqueous solution and to evaluate the proton coupled one electron reduction potential of 2NO to 1HNO, which are essential missing information to understand the fate of 2NO in the biological medium. Our results showed that the 1HNO molecule acts mainly as hydrogen bond donor in aqueous solution with an average energy of -5.5  1.3 kcal/mol. The solvation free energy of 1HNO in aqueous solution, computed using three approaches based on the Liner Response Theory revealed that the current prediction of the hydration free energy of HNO is, at least, two times underestimated...
June 16, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28621919/insights-on-tuning-the-nanostructure-of-rgo-laminate-membranes-for-low-pressure-osmosis-process
#16
Qiuze Wang, Cyril Aubry, Yaxin Chen, Huaihe Song, Linda Zou
In this research, rGO laminates were prepared by a controlled partial reduction step, aimed to avoid aggregation and tune the interlayer spacing (d) between the rGO layers. The mild reducing agent vitamin C (L-AA) and cross-linker polycarboxilic acids were used to improve the stability of the assembled rGO laminate membranes. AFM was used for the first time to further investigate the statistical size distribution of spacing between rGO layers. Topographical images of the edges of the rGO layers were obtained with an AFM instrument, interlayer spacing profiles were extracted and then the data was plotted and fitted with Gaussian curves...
June 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28618986/inflammatory-and-oxidative-stress-markers-as-indicator-of-atherogenesis-in-rats-antioxidants-as-preventive-pharmacological-methods
#17
Maria Del Carmen Baez, Mariana Tarán, María de La Paz Scribano, Ariel Balceda, Carla Buonanotte, Sergio Blencio, Ismael Fonseca, Monica Moya
The oxidative process in atherogenesis generated by proinflammatory induction and response to antioxidants vitamins in an experimental model were analyzed. METHODS: Male rats were used: (A)Control, (B)Control+vitamin E plus C, (C)Hyperfibrinogenemia and (D)Hyperfibrinogenemia+vitamins E plus C. Hyperfibrinogenemia induced by daily injection of adrenaline (0.1mg/day/rat) for 120 days. TREATMENT: 3.42 mg/kg of vitamin E plus 2.14 mg/kg of vitamin C, fifteen days after induction...
June 16, 2017: Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28618722/antioxidants-status-in-type-2-diabetic-patients-in-morocco
#18
Rachid Eljaoudi, Naoual Elomri, Meryem Laamarti, Yahia Cherrah, Taoufik Amezyane, Driss Ghafir, Azeddine Ibrahimi
BACKGROUND/AIM: Type 2 diabetes is a heterogeneous and multifactorial metabolic disorder with some relationship to oxidative stress (OS). Since no studies were conducted in the Moroccan population, this clinical investigation aimed at evaluating the antioxidants status in Moroccan patients with type 2 diabetes. MATERIALS AND METHODS: Blood samples of 60 type 2 diabetic patients and 40 healthy controls subjects were analyzed for determination of glycemia, hemoglobin, CRP, glycated hemoglobin, lipid parameters, malondialdehyde (MDA), vitamins E and C, copper (Cu), zinc (Zn), and selenium (Se)...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28616377/blue-after-splenectomy
#19
Taaran Cariappa Ballachanda Subbaiah, Jeremy P Feldman
INTRODUCTION: We present a 51 year old, African American, female who presented with persistent hypoxemia. She had been taking dapsone for many years for prophylaxis against Pneumocystic Jiroveci with no symptoms but eventually developed methemoglobinemia only after a splenectomy. From our literature review there are no documented cases that have demonstrated this relationship between dapsone, splenic function and methemoglobin and we hope to share our perplexing case and shed light on the interaction...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28612123/the-influence-of-vitamin-c-on-the-interaction-between-acute-mental-stress-and-endothelial-function
#20
Meghan D Plotnick, Katrina A D'Urzo, Brendon J Gurd, Kyra E Pyke
PURPOSE: To determine whether orally administered vitamin C attenuates expected mental stress-induced reductions in brachial artery endothelial function as measured by flow-mediated dilation (FMD). METHODS: Fifteen men (21 ± 2 years) were given 1000 mg of vitamin C or placebo over two visits in a randomized, double-blinded, within-subject design. Acute mental stress was induced using the Trier Social Stress Test (TSST). Saliva samples for cortisol determination and FMD measures were obtained at baseline, pre-TSST, and 30 and 90-min post-TSST...
June 13, 2017: European Journal of Applied Physiology
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