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"Vitamin c"

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https://www.readbyqxmd.com/read/28813027/sulfonamide-linked-ciprofloxacin-sulfadiazine-and-amantadine-derivatives-as-a-novel-class-of-inhibitors-of-jack-bean-urease-synthesis-kinetic-mechanism-and-molecular-docking
#1
Pervaiz Ali Channar, Aamer Saeed, Fernando Albericio, Fayaz Ali Larik, Qamar Abbas, Mubashir Hassan, Hussain Raza, Sung-Yum Seo
Sulfonamide derivatives serve as an important building blocks in the drug design discovery and development (4D) process. Ciprofloxacin-, sulfadiazine- and amantadine-based sulfonamides were synthesized as potent inhibitors of jack bean urease and free radical scavengers. Molecular diversity was explored and electronic factors were also examined. All 24 synthesized compounds exhibited excellent potential against urease enzyme. Compound 3e (IC50 = 0.081 ± 0.003 µM), 6a (IC50 = 0.0022 ± 0.0002 µM), 9e (IC50 = 0...
August 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28808408/anti-lipid-potential-of-drimys-brasiliensis
#2
Josueli Merotto, Larissa Vivan Cestonaro, Luciana Grazziotin Rossato-Grando, Luciano de Oliveira Siqueira, Charise Dallazem Bertol
BACKGROUND: The traditional use of Drimys brasiliensis Miers (Winteraceae) in the south of Brazil to reduce cholesterol has not been described in scientific literature. OBJECTIVE: To verify the hypocholesterolemic effects of D. brasiliensis using rats as animal model. MATERIALS AND METHODS: The bark of D. brasiliensis was extracted with water with further lyophilization and was subjected to phytochemical analysis by high-performance liquid chromatography (HPLC), and free radical scavenging activities by 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay to determine antioxidant potential...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28806736/unravelling-the-interplay-of-sphingolipids-and-tgf-%C3%AE-signaling-in-the-human-corneal-stroma
#3
Sarah E Nicholas, Tyler G Rowsey, Shrestha Priyadarsini, Nawajes A Mandal, Dimitrios Karamichos
PURPOSE: To delineate the role of Sphingolipids (SPLs) in the human cornea and their cross-talks with transforming growth factor beta (TGF-β) in order to develop novel, non-invasive therapies. METHODS: Human corneal fibroblasts (HCFs) were harvested from healthy donors, stimulated with Vitamin C to promote extracellular matrix assembly, treated with exogenous sphingosine-1-phosphate (S1P) or sphingosine kinase inhibitor 2 (SPHK I2) and isolated after 4 weeks for further analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28806113/-hungarian-diet-and-nutritional-status-survey-the-otap2014-study-v-vitamin-intake-of-the-hungarian-population
#4
Erzsébet Schreiberné Molnár, Zsuzsanna Nagy-Lőrincz, Barbara Nagy, Márta Bakacs, Orsolya Kis, Eszter Sarkadi Nagy, Éva Martos
INTRODUCTION AND AIM: The Hungarian Diet and Nutritional Status Survey was implemented on a sub-sample of the European Health Interview Survey. In this paper, the authors present the data on the vitamin intake of the Hungarian population. METHOD: The survey represents the vitamin intake of the Hungarian non-institutionalised adult population of 18 years and older. There are significant differences between men's and women's vitamin intake. RESULTS: The intake of all water-soluble vitamins except for vitamin C is higher in men than in women, and the difference between the genders regarding the intake of vitamin E and D is significant...
August 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28805771/-synergistic-application-of-zinc-and-vitamin-c-to-support-memory-attention-and-the-reduction-of-the-risk-of-the-neurological-diseases
#5
O A Gromova, I Yu Torshin, A V Pronin, M A Kilchevsky
Zinc and vitamin C supplementation of the body is important for CNS functioning. Zinc ions are involved in the neurotransmission (signal transmission from acetylcholine, catecholamine, serotonin, prostaglandin receptors) and in ubiquitin-related protein degradation. Zinc deficits are associated with Alzheimer's disease and depression. Zinc supplementation (10-30 mg daily) improves neurologic recovery rate in patients with stroke and brain injury, has a positive impact on memory and reduces hyperactivity in children...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28805671/the-roles-of-vitamin-c-in-skin-health
#6
REVIEW
Juliet M Pullar, Anitra C Carr, Margreet C M Vissers
The primary function of the skin is to act as a barrier against insults from the environment, and its unique structure reflects this. The skin is composed of two layers: the epidermal outer layer is highly cellular and provides the barrier function, and the inner dermal layer ensures strength and elasticity and gives nutritional support to the epidermis. Normal skin contains high concentrations of vitamin C, which supports important and well-known functions, stimulating collagen synthesis and assisting in antioxidant protection against UV-induced photodamage...
August 12, 2017: Nutrients
https://www.readbyqxmd.com/read/28805668/locally-sustainable-school-lunch-intervention-improves-hemoglobin-and-hematocrit-levels-and-body-mass-index-among-elementary-schoolchildren-in-rural-west-java-indonesia
#7
Makiko Sekiyama, Katrin Roosita, Ryutaro Ohtsuka
School lunch is not provided in public elementary schools in Indonesia, and students frequently buy and eat snacks at school. We hypothesized that providing a traditional Sundanese meal as school lunch would be beneficial for children in rural West Java. To test this hypothesis, we evaluated the effect of a 1-month school lunch intervention aiming at sustainability and based on children's nutritional intake, hemoglobin and hematocrit levels, and body mass index (BMI). A lunch (including rice, vegetable dish, animal protein dish, plant protein dish, and fruit) containing one-third of the recommended daily allowance of energy was offered every school day for 1 month, targeting 68 fourth-grade elementary schoolchildren...
August 12, 2017: Nutrients
https://www.readbyqxmd.com/read/28805101/effect-of-size-and-shape-on-toxicity-of-zinc-oxide-zno-nanomaterials-in-human-peripheral-blood-lymphocytes
#8
Shalini D, Senthilkumar S, Rajaguru P
The multi-industrial applications of zinc oxide nanomaterials (ZnO NMs) lead to increasing exposure to humans. Though the ZnO nanoparticles toxicity had been evaluated previously, toxicity of other forms of ZnO nanomaterials has not been evaluated. In this study, cytotoxicity and genotoxicity of four different types of ZnO NMs were evaluated using human peripheral blood lymphocytes (HPBL). In addition, the effect of anti-oxidants on ZnO NMs induced toxicity was also evaluated. Our results suggest that, size and shape of the nanomaterials have profound effects on their toxicity...
August 13, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28804003/effect-and-proposed-mechanism-of-vitamin-c-modulating-amino-acid-regulation-of-autophagic-proteolysis
#9
Md Razaul Karim, Motoni Kadowaki
Autophagy is an intracellular bulk degradation process, induced under nutrient starvation. Failure of autophagy has been recognized as a contributor to aging and multiple age related neurodegenerative diseases. Improving autophagy is a beneficial anti-aging strategy, however very few physiological regulators have been identified. Here, we demonstrate that vitamin C is a nutritional stimulator of autophagy. Supplementation of fresh hepatocytes with vitamin C increased autophagic proteolysis significantly in the presence of amino acids in a dose- and time-dependent manner, although no effect was observed in the absence of amino acids...
August 10, 2017: Biochimie
https://www.readbyqxmd.com/read/28802295/food-acceptance-and-anthropometry-in-relation-to-6-n-propylthiouracil-sensitivity-in-japanese-college-women
#10
Ayako Nagai, Masaru Kubota, Kanako Morinaga, Yukie Higashiyama
BACKGROUND AND OBJECTIVES: Differences in anthropometry and food acceptance among tasters and non-tasters of 6-n-propylthiouracil has been well studied in Western countries. However, reports on this issue from Asian countries are still limited. METHODS AND STUDY DESIGN: Healthy Japanese students attending Nara Women's University (n=153) were recruited and classified into 3 groups based on taste sensitivity to a 0.32 mM 6-npropylthiouracil solution as scored on a labeled magnitude scale...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28794209/phylloquinone-intake-is-associated-with-cardiac-structure-and-function-in-adolescents
#11
Mary K Douthit, Mary Ellen Fain, Joshua T Nguyen, Celestine F Williams, Allison H Jasti, Bernard Gutin, Norman K Pollock
Background: Associations between childhood vitamin K consumption and cardiac structure and function have not been investigated.Objective: We determined associations between phylloquinone (vitamin K-1) intake and left ventricular (LV) structure and function in adolescents.Methods: We assessed diet with three to seven 24-h recalls and physical activity (PA) by accelerometry in 766 adolescents (aged 14-18 y, 50% female, 49% black). Fat-free soft tissue (FFST) mass and fat mass were measured by dual-energy X-ray absorptiometry...
August 9, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28791778/redox-properties-of-transitional-milk-from-mothers-of-preterm-infants
#12
Simeon Minić, Miloš Ješić, Dijana Đurović, Srdjan Miletić, Nikoleta Lugonja, Vesna Marinković, Aleksandra Nikolić-Kokić, Snežana Spasić, Miroslav M Vrvić
AIM: There is a discrepancy between the amount of transitional milk produced by mothers of preterm infants and the low capacity of premature infants to consume it. This milk can be used in milk banks, but previous studies found that there are large variations in the level of host-defence proteins in individual samples of milk from mothers of premature infants, which implies that large individual variations in antioxidative defence composition are also possible. METHODS: Milk samples were collected from 20 healthy mothers of preterm infants...
August 9, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28791253/potential-role-of-metabolic-intervention-in-the-management-of-advanced-differentiated-thyroid-cancer
#13
Sri Harsha Tella, Anuhya Kommalapati, Mary Angelynne Esquivel, Ricardo Correa
Well-differentiated thyroid carcinoma (DTC) is the most common endocrine malignancy that has an excellent prognosis with a 5-year survival rate of about 98%. However, approximately 50% of the patients with DTC who present with distant metastases (advanced DTC) die from the disease within 5 years of initial diagnosis even after getting the appropriate therapy. Apart from recent advancements in chemotherapy agents, the potential role of metabolic interventions, including the use of metformin, ketogenic diet, and high-dose vitamin C in the management of advanced cancers have been investigated as a less toxic co-adjuvant therapies...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28790401/the-manipulation-of-gene-expression-and-the-biosynthesis-of-vitamin-c-e-and-folate-in-light-and-dark-germination-of-sweet-corn-seeds
#14
Fengyuan Liu, Nan Xiang, Jian Guang Hu, Yan Shijuan, Lihua Xie, Charles Stephen Brennan, Wenjie Huang, Xinbo Guo
This study investigates the potential interrelationship between gene expression and biosynthesis of vitamin C, E and folate in sweet corn sprouts. Germination of sweet corn kernels was conducted in light and dark environments to determine if this relationship was regulated by photo-illumination. Results indicated that light and dark environments affected the DHAR, TMT and GTPCH expression and that these genes were the predominant genes of vitamin C, E and folate biosynthesis pathways respectively during the germination...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28789864/ethanol-exposure-leads-to-disorder-of-blood-island-formation-in-early-chick-embryo
#15
Guang Wang, Bin-Zhen Chen, Chao-Jie Wang, Jing Zhang, Lin-Rui Gao, Manli Chuai, Yongping Bao, Xuesong Yang
Ethanol's effect on embryonic vasculogenesis and its underlying mechanism is obscure. Using VE-cadherin in situ hybridization, we found blood islands formation was inhibited in area opaca, but abnormal VE-cadherin(+) cells were seen in area pellucida. We hypothesise ethanol may affect blood island progenitor cell migration and differentiation. DiI and in vitro experiments revealed ethanol inhibited cell migration, Quantitative PCR analysis revealed that ethanol exposure enhanced cell differentiation in area pellucida of HH5 chick embryos and repressed cell differentiation in area pellucida of HH8 chick embryos...
August 5, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28771745/biostimulants-from-food-processing-by-products-agronomic-quality-and-metabolic-impacts-on-organic-tomato-solanum-lycopersicum-l
#16
Lara Abou Chehade, Ziad Al Chami, Sandra Angelica De Pascali, Ivana Cavoski, Francesco Paolo Fanizzi
BACKGROUND: Biostimulants have gained recently an increased attention due to their multiple benefits for sustainable agriculture. In this study, three food processing by-products - fennel processing residues (FPR), lemon processing residues (LPR) and brewers' spent grain (BSG) - were investigated as potential sources of biostimulants. Their aqueous extracts as individual and associated applications were assessed for their effects on agronomic, quality and metabolic performances of organic tomato in comparison to humic substances extract (HS) and untreated control (CTRL)...
August 3, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28771433/the-impact-of-vitamin-c-on-the-relationship-among-inflammation-lipid-peroxidation-and-platelet-activation-during-analgesic-nephropathy-in-rats
#17
Nikola Hadzi-Petrushev, Dine Mitrov, Vladimir Kostovski, Mitko Mladenov
BACKGROUND: Oxidative stress and inflammation are involved in the pathogenesis of paracetamol-induced renal damage. This study examines the relationship between 8-iso-prostaglandin F2α (8-iso-PGF2α) and platelet activation as well as the relative contribution of the pro-inflammatory markers interleukin (IL)-1β and tumor necrosis factor-α (TNF-α) in enhanced 8-iso-PGF2α biosynthesis, as a complementary onset during analgesic nephropathy induced by chronic treatment with paracetamol...
August 3, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28771190/vitamin-c-status-correlates-with-markers-of-metabolic-and-cognitive-health-in-50-year-olds-findings-of-the-chalice-cohort-study
#18
John F Pearson, Juliet M Pullar, Renee Wilson, Janet K Spittlehouse, Margreet C M Vissers, Paula M L Skidmore, Jinny Willis, Vicky A Cameron, Anitra C Carr
A cohort of 50-year-olds from Canterbury, New Zealand (N = 404), representative of midlife adults, undertook comprehensive health and dietary assessments. Fasting plasma vitamin C concentrations (N = 369) and dietary vitamin C intake (N = 250) were determined. The mean plasma vitamin C concentration was 44.2 µmol/L (95% CI 42.4, 46.0); 62% of the cohort had inadequate plasma vitamin C concentrations (i.e., <50 µmol/L), 13% of the cohort had hypovitaminosis C (i.e., <23 µmol/L), and 2.4% had plasma vitamin C concentrations indicating deficiency (i...
August 3, 2017: Nutrients
https://www.readbyqxmd.com/read/28770950/prevention-of-neural-tube-defects-and-maternal-gestational-diabetes-through-the-inositol-supplementation-preliminary-results
#19
D Dell'Edera, F Sarlo, A Allegretti, A A Epifania, F Simone, M G Lupo, M Benedetto, M R D'Apice, A Capalbo
OBJECTIVE: Our study aims to demonstrate that the use in the preconceptional period until the 24th week of pregnancy of inositol and folic acid, first of all, preserves the product of conception from neural tube defects (NTDs) and then, thanks to inositol supplementation, it possibly counteracts and prevents the onset of maternal gestational diabetes (GDM). PATIENTS AND METHODS: We have collected data derived from pregnant women arrived at our laboratory, from January 2014 to January 2016, with no family history of type 2 diabetes and hypertension...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28770182/effects-of-vitamin-c-supplementation-on-plasma-and-urinary-vitamin-c-concentration-in-korean-women
#20
Jayoung Choi, Do-Yeon Kim, Ryowon Choue, Hyunjung Lim
Although vitamin C supplements were consumed for health maintenance and fatigue recovery, the effects of high doses of vitamin C supplement remains controversial. Our study performed the effects of 100 mg and 2,000 mg vitamin C supplements on plasma and urinary vitamin C concentration in Korean women. Twenty-four women completed the 4 weeks intervention. Anthropometric data, plasma and urinary vitamin C concentrations, superoxide dismutase activity, thiobarbituric acid reactive substance (TBARS) level, and fatigue severity scale (FSS) were collected, and the statistical analyses compared between- and within-group findings at pre- and post-intervention...
July 2017: Clinical Nutrition Research
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