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"Vitamin c"

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https://www.readbyqxmd.com/read/27909615/the-histopathological-evaluation-of-healing-effects-of-vitamin-c-administered-before-methotrexate-therapy-on-testicular-injury-induced-by-methotrexate
#1
Aysun Sayılmaz, Yasemin Yuyucu Karabulut, Aydan Özgörgülü
OBJECTIVE: Methotrexate (MTX) leads to acute toxic side effects in tissues or organs containing rapidly dividing cells such as seminiferous tubules. In this study, we investigated the protective effects of vitamin C against MTX-induced injury in rat testis. MATERIAL AND METHODS: A total of 31 rats were divided into 4 groups, including the control group. The study was completed within 4 weeks and the rats received daily doses of 2 mL/kg SF, 100 mg/kg vitamin C and 10 mg/kg/day MTX i...
December 2016: Turkish Journal of Urology
https://www.readbyqxmd.com/read/27908410/elevated-serum-mda-and-depleted-non-enzymatic-antioxidants-macro-minerals-and-trace-elements-are-associated-with-bipolar-disorder
#2
Manjurul Islam Chowdhury, Maimuna Hasan, Mohammad Safiqul Islam, Md Shahid Sarwar, Mohammad Nurul Amin, S M Naim Uddin, Md Zahedur Rahaman, Sujan Banik, Md Saddam Hussain, Kazushige Yokota, Abul Hasnat
Genetic and neurobiological factors are considered to be the major causes of mood and mental disorders. However, over the past few years, increased levels of serum malondialdehyde and altered levels of various non-enzymatic antioxidants and essential minerals involved in abnormal functional activity have been identified as major contributing factors to the pathogenesis of several neurological disorders. The aim of this study was to determine the levels of the serum lipid peroxidation product malondialdehyde (MDA), antioxidants (vitamin A, E and C), macro-minerals (calcium, potassium and sodium) and trace elements (zinc, iron and selenium) in patients with bipolar disorder and to explore their role in disease progression...
January 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27904560/development-validity-and-reliability-of-a-food-frequency-questionnaire-for-antioxidants-in-elderly-iranian-people
#3
Mahsa Malekahmadi, Amirmansour Alavi Naeini, Sakineh Shab-Bidar, Awat Feizi, Abolghasem Djazayery
BACKGROUND: The food frequency questionnaire (FFQ), as a way to assess the dietary intake in comparison with other methods, is easier to analyze and takes less time and is less costly. Our aim in this study was to develop and validate an FFQ for estimating the intakes of selected antioxidants in elderly Iranian people. MATERIALS AND METHODS: A total of 185 elderly people were randomly selected. Three-day food records were completed by the subjects and collected every 2 months and dietary intake levels of zinc, selenium, carotenes and vitamins C and E were estimated...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27904400/16s-rrna-in-situ-hybridization-followed-by-flow-cytometry-for-rapid-identification-of-acetic-acid-bacteria-involved-in-submerged-industrial-vinegar-production
#4
Janja Trček, Luka Lipoglavšek, Gorazd Avguštin
Acetic acid bacteria are involved in many biotechnological processes such as vitamin C, gluconic acid, miglitol or acetic acid production, and others. For a technologist trying to control the industrial process, the ability to follow the microbiological development of the process is thus of importance. During the past few years hybridization in a combination with flow cytometry has often been used for this purpose. Since vinegar is a liquid, it is an ideal matrix for flow cytometry analysis. In this work we have constructed a specific probe for highly acetic acid-resistant species of the acetic acid bacteria and a protocol for in situ hybridization, which in combination with flow cytometry enables direct monitoring of bacteria producing vinegar with >10% of acetic acid...
March 2016: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/27904390/ascorbate-oxidase-based-amperometric-biosensor-for-l-ascorbic-acid-determination-in-beverages
#5
Gábor Csiffáry, Péter Fűtő, Nóra Adányi, Attila Kiss
A novel biosensor for l-ascorbic acid determination in different beverages was elaborated. The ascorbate oxidase enzyme (AAO) from Cucurbita sp., EC 1.10.3.3, was immobilized on a screen-printed carbon electrode with poly(ethylene glycol) (400) diglycidyl ether (PEGDGE) as a crosslinking agent. The standards and samples were measured first with a blank electrode. An inert protein, bovine serum albumin (BSA), was immobilized on the surface of this electrode with PEGDGE. The BSA mass was equivalent to the mass of 10 U of AAO enzyme immobilized on the electrodes (0...
March 2016: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/27904265/a-study-of-intravenous-administration-of-vitamin-c-in-the-treatment-of-acute-herpetic-pain-and-postherpetic-neuralgia
#6
Min Sung Kim, Dong Jin Kim, Chan Ho Na, Bong Seok Shin
BACKGROUND: Although there are several available management strategies for treatment of both acute pain of herpes zoster (HZ) and postherpetic neuralgia (PHN), it is difficult to treat them adequately. OBJECTIVE: The aim of this study was to evaluate the efficacy of intravenously administrated vitamin C on acute pain and its preventive effects on PHN in patients with HZ. METHODS: Between September 2011 and May 2013 eighty-seven patients who were admitted for HZ were assessed according to age, sex, underlying diseases, duration of pain and skin lesion, dermatomal distribution, and PHN...
December 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27903840/evaluation-of-antioxidant-intakes-in-relation-to-inflammatory-markers-expression-within-the-normal-breast-tissue-of-breast-cancer-patients
#7
Danielle Larouche, Mirette Hanna, Sue-Ling Chang, Simon Jacob, Bernard Têtu, Caroline Diorio
Chronic inflammation may be a causative factor in breast cancer. One possible underlying mechanism is the generation of oxidative stress, which may favor tumorigenic processes. Antioxidant consumption may, therefore, help reduce tissue inflammation levels. However, few studies have explored this relation in breast tissue. We aimed to evaluate correlations between antioxidant (vitamin A/retinol, vitamin C, vitamin E, β-carotene, α-carotene, lycopene, lutein/zeaxanthin, β-cryptoxanthin, selenium, and zinc) intakes and protein expression levels of interleukin (IL)-6, tumor necrosis factor-α, C-reactive protein, cyclooxygenase-2, leptin, serum amyloid A1, signal transducer and activator of transcription 3, IL-8, IL-10, lactoferrin, and transforming growth factor-β measured in the normal breast tissue of 160 women diagnosed with breast cancer...
November 30, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27901495/air-pollution-and-dna-methylation-alterations-in-lung-cancer-a-systematic-and-comparative-study
#8
Cheng-Lan Jiang, Shui-Wang He, Yun-Dong Zhang, He-Xian Duan, Tao Huang, Yun-Chao Huang, Gao-Feng Li, Ping Wang, Li-Ju Ma, Guang-Biao Zhou, Yi Cao
The lung cancer incidence in the Xuanwei and neighboring region, Yunnan, China, is among the highest in China and is attributed to severe air pollution with high benzo(a)pyrene levels. We systematically and comparatively analyzed DNA methylation alterations at genome and gene levels in Xuanwei lung cancer tissues and cell lines, as well as benzo(a)pyrene-treated cells and mouse samples. We obtained a comprehensive dataset of genome-wide cytosine-phosphate-guanine island methylation in air pollution-related lung cancer samples...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27900959/effect-of-vitamin-c-supplementation-on-lipid-profile-serum-uric-acid-and-ascorbic-acid-in-children-on-hemodialysis
#9
Ghada Mohamed El Mashad, Hanan M ElSayed, Nahla A Nosair
Children with end-stage renal disease (ESRD) suffer from dyslipidemia and hyperuricemia that might play a causal role in the progression of cardiovascular disease (CVD). The aim of the study is to assess the effects of Vitamin C supplementation on uric acid, ascorbic acid, and serum lipid levels among children on hemodialysis (HD). This prospective study was conducted in the pediatric nephrology unit at Menoufia University Hospital. The study included a total of 60 children with ESRD on maintenance HD therapy...
November 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/27900409/perspectives-and-challenges-of-antioxidant-therapy-for-atrial-fibrillation
#10
REVIEW
Iveta Gasparova, Peter Kubatka, Radka Opatrilova, Martin Caprnda, Slavomira Filipova, Luis Rodrigo, Leone Malan, Ioana Mozos, Miroslava Rabajdova, Vladimir Nosal, Nazarii Kobyliak, Vanda Valentova, Daniel Petrovic, Mariusz Adamek, Peter Kruzliak
Atrial fibrillation (AF) is the most common sustained arrhythmia associated with significant morbidity and mortality. The mechanisms underlying the pathogenesis of AF are poorly understood, although electrophysiological remodeling has been described as an important initiating step. There is growing evidence that oxidative stress is involved in the pathogenesis of AF. Many known triggers of oxidative stress, such as age, diabetes, smoking, and inflammation, are linked with an increased risk of arrhythmia. Numerous preclinical studies and clinical trials reported the importance of antioxidant therapy in the prevention of AF, using vitamins C and E, polyunsaturated fatty acids, statins, or nitric oxide donors...
November 29, 2016: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/27899367/intake-of-key-micronutrients-and-food-groups-in-patients-with-late-stage-age-related-macular-degeneration-compared-with-age-sex-matched-controls
#11
Bamini Gopinath, Gerald Liew, Joanna Russell, Victoria Cosatto, George Burlutsky, Paul Mitchell
BACKGROUND: Knowledge of the risk factor profile of patients presenting with late-stage age-related macular degeneration (AMD) could help identify the most frequent modifiable AMD precursors among people who are referred for treatment. We aimed to assess dietary behaviours by comparing adjusted mean intakes of micronutrients and major food groups (fruits, vegetables, fish) among patients with AMD and a sample of age-sex-matched controls. METHODS: Cross-sectional analysis of 480 late AMD cases and 518 population-based age-sex-matched controls with no AMD signs...
November 29, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27899116/the-correlation-between-antimutagenic-activity-and-total-phenolic-content-of-extracts-of-31-plant-species-with-high-antioxidant-activity
#12
Tshepiso Jan Makhafola, Esameldin Elzein Elgorashi, Lyndy Joy McGaw, Luc Verschaeve, Jacobus Nicolaas Eloff
BACKGROUND: Antimutagenic activity of plant extracts is important in the discovery of new, effective cancer preventing agents. There is increasing evidence that cancer and other mutation-related diseases can be prevented by intake of DNA protective agents. The identification of antimutagenic agents present in plants presents an effective strategy to inhibit pathogenic processes resulting from exposure to mutagenic and/or carcinogenic substances present in the environment. There are no reports on the antimutagenic activities of the plant species investigated in this study...
November 29, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27898872/the-effect-of-oxidative-stress-during-exercise-in-the-horse
#13
C A Williams
Oxidative stress is an imbalance of the oxidant-to-antioxidant ratio in the body. Increases in oxidative stress and changes in antioxidant status have been shown during endurance and intense exercise and eventing competition in horses. Antioxidants include vitamins, minerals, enzymes, and proteins that must be synthesized in the body or obtained from the diet. Therefore, exercise level and diet are both factors that play a role in influencing the oxidative stress and antioxidant status of the equine athlete...
October 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27898731/reproducibility-and-validity-of-a-food-frequency-questionnaire-designed-to-assess-diet-in-children-aged-4-5-years
#14
Jesus Vioque, Daniel Gimenez-Monzo, Eva Maria Navarrete-Muñoz, Manuela Garcia-de-la-Hera, Sandra Gonzalez-Palacios, Marisa Rebagliato, Ferran Ballester, Mario Murcia, Carmen Iñiguez, Fernando Granado
BACKGROUND: The food frequency questionnaire (FFQ) is the most efficient and cost-effective method to investigate the relationship between usual diet and disease in epidemiologic studies. Although FFQs have been validated in many adult populations worldwide, the number of valid FFQ in preschool children is very scarce. The aim of this study was to evaluate the reproducibility and validity of a semi-quantitative FFQ designed for children aged 4 to 5 years. MATERIALS AND METHODS: In this study, we have included 169 children aged 4-5 years from the INMA project in Valencia, a population-based prospective cohort study of mothers and children in Spain...
2016: PloS One
https://www.readbyqxmd.com/read/27897391/a-systematic-review-on-the-role-of-vitamins-minerals-proteins-and-other-supplements-for-the-treatment-of-cachexia-in-cancer-a-european-palliative-care-research-centre-cachexia-project
#15
REVIEW
Mochamat, Henning Cuhls, Milka Marinova, Stein Kaasa, Christiane Stieber, Rupert Conrad, Lukas Radbruch, Martin Mücke
We provide a systematic review to support the European Palliative Care Research Collaboration development of clinical guidelines for cancer patients suffering from cachexia. CENTRAL, MEDLINE, PsycINFO, ClinicalTrials.gov, and a selection of cancer journals have been searched up until 15 April 2016. The systematic literature research yielded 4214 publications with 21 of these included in the final evaluation. Regarding minerals, our search identified only one study examining the use of magnesium with no effect on weight loss...
July 20, 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27895802/vitamin-c-induces-apoptosis-in-ags-cells-via-production-of-ros-of-mitochondria
#16
Jae Young Lim, Donghyun Kim, Bok Ran Kim, Jin Su Jun, Jung Sook Yeom, Ji Sook Park, Ji-Hyun Seo, Chan Hoo Park, Hyang Ok Woo, Hee-Shang Youn, Seung-Chul Baik, Woo-Kon Lee, Myung-Je Cho, Kwang-Ho Rhee
It has been demonstrated that vitamin C exhibits anti-cancer activity in various tumor cell lines; however, its specific mechanism of action remains unknown. Although the diagnosis and therapy of cancer patients have markedly improved in recent years, safer and more cost-effective treatments are still required. Therefore, the present study examined the effect of vitamin C on the induction of cell death in gastric cancer and its underlying mechanism of action. It was observed that the cytotoxicity of vitamin C on the human gastric cancer cell line AGS is dependent on the apoptotic pathway, including caspase cascades, but not on the necroptotic pathway...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27894590/preconditioning-with-azadirachta-indica-ameliorates-cardiorenal-dysfunction-through-reduction-in-oxidative-stress-and-extracellular-signal-regulated-protein-kinase-signalling
#17
Temidayo Olutayo Omóbòwálé, Ademola Adetokunbo Oyagbemi, Olumuyiwa Abiola Adejumobi, Eguonor Vivian Orherhe, Adetayo Sadudeen Amid, Adeolu Alex Adedapo, Helen Olubukola Nottidge, Momoh Audu Yakubu
BACKGROUND: Azadirachta indica is widely distributed in Africa, Asia and other tropical parts of the world. A.indica (AI) is traditionally used for the treatment of several conditions including cancer, hypertension, heart diseases and skin disorders. Intestinal ischaemia-reperfusion is a common pathway for many diseases and may lead to multiple organ dysfunction syndrome and death. OBJECTIVE: In this study, we investigated the ameliorative effects of AI on intestinal ischaemia-reperfusion injury-induced cardiorenal dysfunction...
November 25, 2016: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/27894288/bactericidal-and-antioxidant-properties-of-essential-oils-from-the-fruits-dennettia-tripetala-g-baker
#18
Sunday O Okoh, Benson C Iweriegbor, Omobola O Okoh, Uchechukwu U Nwodo, Anthony I Okoh
BACKGROUND: The antibacterial and antioxidant properties of the essential oils (EOs) of unripe and ripe fruits of Dennettia tripetala and their potential for the management of infectious and oxidative-stress diseases were investigated in-vitro in this study. METHOD: Essential oil obtained from the fruit in Clevenger modified apparatus, was characterized by high resolution GC-MS, while antioxidant and antibacterial properties were tested by spectrophotometric and agar diffusion methods respectively...
November 28, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27892893/photoprotective-and-radioprotective-properties-of-nitroxides-and-their-application-in-magnetic-resonance-imaging
#19
Marcin Lewandowski, Krzysztof Gwoździński
Nitroxides are a group of stable organic radicals of low molecular weight having a nitroxyl group > N-.O, which has an unpaired electron. The presence of this group allows a nitroxide to participate in redox reactions. They serve as mimics of superoxide dismutase (SOD) and have stimulative properties towards haemoproteins with catalase-like activity. Nitroxides oxidize Fe (II) to Fe (III) preventing the Fenton and Haber-Weiss reactions. As the radicals have the ability to scavenge other free radicals. Nitroxides are not immunogenic, and mutagenic and do not show toxicity to the human cells...
October 14, 2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/27891661/synergistic-effects-of-polydatin-and-vitamin-c-in-inhibiting-cardiotoxicity-induced-by-doxorubicin-in-rats
#20
Hui-Lin Wang, Xiao-Hua Cui, Hai-Lun Yu, Rong Wu, Xu Xu, Jian-Ping Gao
The purpose of this study was to assess the synergistic effect of polydatin and vitamin C on attenuating cardiotoxicity induced by doxorubicin (DOX) in rats. Polydatin could significantly increase the activity of SOD and the heart rate, attenuate myocardial pathological damage, decrease MDA content, slightly increase arterial pressure and GSH-Px activity, reduce intervals of QRS, QT and ST, and lower FFA content. The combination of polydatin and vitamin C could significantly increase arterial pressure and heart rate, decrease QRS interval and slightly reduce ST and QT intervals, significantly attenuate myocardial pathological damage, increase the activities of GSH-Px,T-SOD, Na(+) K(+) -ATPase and Ca(2+) Mg(2+) -ATPase, and elevate PCr and ATP contents, slightly increase ADP and TAN contents and PCr/ATP, and significantly decrease the contents of MDA and FFA, when compared with those in the DOX group...
November 28, 2016: Fundamental & Clinical Pharmacology
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