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Influenza vaccine 2016-2017

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https://www.readbyqxmd.com/read/28792867/influenza-vaccine-effectiveness-in-the-united-states-during-the-2015-2016-season
#1
Michael L Jackson, Jessie R Chung, Lisa A Jackson, C Hallie Phillips, Joyce Benoit, Arnold S Monto, Emily T Martin, Edward A Belongia, Huong Q McLean, Manjusha Gaglani, Kempapura Murthy, Richard Zimmerman, Mary P Nowalk, Alicia M Fry, Brendan Flannery
BACKGROUND: The A(H1N1)pdm09 virus strain used in the live attenuated influenza vaccine was changed for the 2015-2016 influenza season because of its lack of effectiveness in young children in 2013-2014. The Influenza Vaccine Effectiveness Network evaluated the effect of this change as part of its estimates of influenza vaccine effectiveness in 2015-2016. METHODS: We enrolled patients 6 months of age or older who presented with acute respiratory illness at ambulatory care clinics in geographically diverse U...
August 10, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28780977/predominance-of-influenza-a-h3n2-virus-genetic-subclade-3c-2a1-during-an-early-2016-17-influenza-season-in-europe-contribution-of-surveillance-data-from-world-health-organization-who-european-region-to-the-who-vaccine-composition-consultation-for-northern-hemisphere
#2
Angeliki Melidou, Eeva Broberg
During the European 2016/17 influenza season, A(H3N2) viruses have predominated and the majority clustered in genetic subclade 3C.2a1. Genetic analyses showed that circulating viruses have undergone considerable genetic diversification of the haemagglutinin gene from the current vaccine virus A/Hong Kong/4801/2014 (clade 3C.2a), but the antigenic data that is limited by the challenges with the antigenic characterisation of currently circulating A(H3N2) viruses, showed no clear evidence of antigenic change. The recommended A(H3N2) vaccine component for the northern hemisphere 2017/18 influenza season remained unchanged...
August 3, 2017: Vaccine
https://www.readbyqxmd.com/read/28760609/influenza-vaccination-rates-in-children-decline-when-the-live-attenuated-influenza-vaccine-is-not-recommended
#3
Benjamin Fogel, Steven Hicks
BACKGROUND: In 2016 the Centers for Disease Control and Prevention (CDC) recommended against using the live attenuated influenza vaccine (LAIV) for the 2016-2017 influenza season. This recommendation is potentially important for vaccination rates because perceived effectiveness and ease of administration are among the primary determinants of families decisions to vaccinate their children. This investigation sought to determine whether rates of pediatric influenza vaccination changed in a season when the LAIV was not recommended...
July 28, 2017: Vaccine
https://www.readbyqxmd.com/read/28734139/%C3%AE-nfluenza-a-h3n2-genetic-variants-in-vaccinated-patients-in-northern-greece
#4
A Melidou, G Gioula, M Exindari, E Ioannou, K Gkolfinopoulou, T Georgakopoulou, S Tsiodras, A Papa
BACKGROUND: Influenza A(H3N2) viruses predominated during the influenza 2016/2017 season and showed extensive genetic diversification. A high vaccination failure rate was noticed during the 2016/17 season in Greece, especially among the elderly. OBJECTIVES: The scope of the study was to investigate the genetic characteristics of A(H3N2) circulating viruses and viruses detected in vaccinated patients. STUDY DESIGN: Virus samples originated from vaccinated and unvaccinated patients, obtained at the National Influenza Centre for northern Greece...
July 14, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28697522/childhood-vaccination-against-seasonal-influenza-to-reduce-the-overall-burden-of-disease-ethical-perspectives
#5
Kyriakos Martakis, Kruthika Thangavelu, Peter Schröder-Bäck
Introduction Childhood immunisation against seasonal influenza promises to reduce the burden of disease through herd immunity. The option of intranasal vaccination seemed to offer a more acceptable vaccination for children, as they are perceived to be less invasive. Yet, intranasal vaccines have been recently proven not to be as effective as presumed. In Germany, contradictory recommendations of the Standing Committee on Vaccination (STIKO) first, to use and then, in October 2016, not use these vaccines have been issued for the 2016-2017 season, whereas recommendations not to use them were already issued in the USA (CDC, ACIP)...
July 11, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28672275/genetic-divergence-of-influenza-a-h3n2-amino-acid-substitutions-mark-the-beginning-of-the-2016-2017-winter-season-in-israel
#6
Aharona Glatman-Freedman, Yaron Drori, Sharon Alexandra Beni, Nehemya Friedman, Rakefet Pando, Hanna Sefty, Ilana Tal, John McCauley, Galia Rahav, Nathan Keller, Tamy Shohat, Ella Mendelson, Musa Hindiyeh, Michal Mandelboim
BACKGROUND: Influenza vaccine composition is reevaluated each year due to the frequency and accumulation of genetic changes that influenza viruses undergo. The beginning of the 2016-2017 influenza surveillance period in Israel has been marked by the dominance of influenza A(H3N2). OBJECTIVES: To evaluate the type, subtype, genetic evolution and amino acid substitutions of influenza A(H3N2) viruses detected among community patients with influenza-like illness (ILI) and hospitalized patients with respiratory illness in the first weeks of the 2016-2017 influenza season...
June 4, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28662019/update-influenza-activity-in-the-united-states-during-the-2016-17-season-and-composition-of-the-2017-18-influenza-vaccine
#7
Lenee Blanton, Noreen Alabi, Desiree Mustaquim, Calli Taylor, Krista Kniss, Natalie Kramer, Alicia Budd, Shikha Garg, Charisse N Cummings, Jessie Chung, Brendan Flannery, Alicia M Fry, Wendy Sessions, Rebecca Garten, Xiyan Xu, Anwar Isa Abd Elal, Larisa Gubareva, John Barnes, Vivien Dugan, David E Wentworth, Erin Burns, Jacqueline Katz, Daniel Jernigan, Lynnette Brammer
During the 2016-17 influenza season (October 2, 2016-May 20, 2017) in the United States, influenza activity* was moderate. Activity remained low through November, increased during December, and peaked in February nationally, although there were regional differences in the timing of influenza activity. Influenza A(H3N2) viruses predominated through mid-March and were predominant overall for the season, but influenza B viruses were most commonly reported from late March through May. This report summarizes influenza activity in the United States during October 2, 2016-May 20, 2017(†) and updates the previous summary (1)...
June 30, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28542417/interim-estimates-of-the-effectiveness-of-the-influenza-vaccine-against-a-h3n2-influenza-in-adults-in-south-korea-2016-2017-season
#8
Ji Yun Noh, Sooyeon Lim, Joon Young Song, Won Suk Choi, Hye Won Jeong, Jung Yeon Heo, Jacob Lee, Yu Bin Seo, Jin-Soo Lee, Seong Heon Wie, Young Keun Kim, Kyung Hwa Park, Sook-In Jung, Shin Woo Kim, Sun Hee Lee, Han Sol Lee, Young Hoon Yoon, Hee Jin Cheong, Woo Joo Kim
In the 2016-2017 season, the A(H3N2) influenza epidemic presented an unusual early peak pattern compared with past seasons in South Korea. The interim vaccine effectiveness (VE) of influenza vaccination in preventing laboratory-confirmed influenza was estimated using test-negative design through the tertiary hospital-based influenza surveillance system in South Korea. From 1 September, 2016 to 7 January, 2017, adjusted VE of influenza vaccination in preventing laboratory-confirmed A(H3N2) was -52.1% (95% confidence interval [CI], -147...
2017: PloS One
https://www.readbyqxmd.com/read/28474707/-behavior-of-influenza-seasons-in-mexico-from-2010-to-2016-analysis-and-prospective
#9
Cuitláhuac Ruiz-Matus, Pablo Kuri-Morales, José Narro-Robles
The influenza virus spreads rapidly through recurring seasonal outbreaks during the fall and winter. Our country has the Epidemiological Surveillance System for Influenza (SISVEFLU), in operation since 2006, which has records of 558 health units of Influenza. According to the information recorded in it, we can see that the 2010-2016 influenza seasons have a biannual behavior, and that in the 2010-2011, 2012-2013, and 2014-2015 seasons, the predominant viral subtype was A (H3N2), while in the 2011-2012, 2013-2014, and 2015-2016 seasons, the predominant subtype was A (H1N1) pdm09, which was associated with an increased number of influenza cases and deaths...
March 2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/28346272/influenza-in-children
#10
Janienne Kondrich, Michele Rosenthal
PURPOSE OF REVIEW: We review the current information and evidence available on the global burden of disease in the pediatric population, clinical presentation and complications, testing, treatment, and immunization. RECENT FINDINGS: In addition to multiple other risk factors for influenza complications, children with neurologic and neuromuscular disorders are significantly higher risk for serious complications. In practice, there is no lower age limit for children with influenza who can be treated with oseltamivir...
June 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28284680/psychological-factors-associated-with-uptake-of-the-childhood-influenza-vaccine-and-perception-of-post-vaccination-side-effects-a-cross-sectional-survey-in-england
#11
Louise E Smith, Rebecca K Webster, John Weinman, Richard Amlôt, Jenny Yiend, G James Rubin
OBJECTIVES: To identify predictors of: uptake of the childhood influenza vaccine in the 2015-2016 influenza season, parental perceptions of side-effects from the influenza vaccine and intention to vaccinate one's child for influenza in the 2016-2017 influenza season. DESIGN: Cross-sectional online survey. SETTING: Data were collected in England shortly after the end of the 2015-2016 immunization campaign. PARTICIPANTS: 1001 parents or guardians of children aged between two and seven...
February 24, 2017: Vaccine
https://www.readbyqxmd.com/read/28279341/attenuated-vaccines-for-augmented-immunity
#12
Stylianos Bournazos, Jeffrey V Ravetch
Live attenuated vaccines are more immunogenic and have the capacity to elicit long-lasting immune responses. In two recent studies, Wang et al. (2017) and Si et al. (2016) describe strategies for the generation of live attenuated influenza viruses, which elicited robust humoral, mucosal, and cellular immunity against diverse virus strains.
March 8, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28278147/increase-in-human-infections-with-avian-influenza-a-h7n9-virus-during-the-fifth-epidemic-china-october-2016-february-2017
#13
A Danielle Iuliano, Yunho Jang, Joyce Jones, C Todd Davis, David E Wentworth, Timothy M Uyeki, Katherine Roguski, Mark G Thompson, Larisa Gubareva, Alicia M Fry, Erin Burns, Susan Trock, Suizan Zhou, Jacqueline M Katz, Daniel B Jernigan
During March 2013-February 24, 2017, annual epidemics of avian influenza A(H7N9) in China resulted in 1,258 avian influenza A(H7N9) virus infections in humans being reported to the World Health Organization (WHO) by the National Health and Family Planning Commission of China and other regional sources (1). During the first four epidemics, 88% of patients developed pneumonia, 68% were admitted to an intensive care unit, and 41% died (2). Candidate vaccine viruses (CVVs) were developed, and vaccine was manufactured based on representative viruses detected after the emergence of A(H7N9) virus in humans in 2013...
March 10, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28263288/a-pilot-randomized-trial-of-adjuvanted-influenza-vaccine-in-adult-allogeneic-hematopoietic-stem-cell-transplant-recipients
#14
Y Natori, A Humar, J Lipton, D D Kim, P Ashton, K Hoschler, D Kumar
The annual influenza vaccine is recommended for hematopoietic stem cell transplant (HSCT) patients although studies have shown suboptimal immunogenicity. Influenza vaccine containing an oil-in-water emulsion adjuvant (MF59) may lead to greater immunogenicity in HSCT recipients. We randomized adult allogeneic HSCT patients to receive the 2015-2016 influenza vaccine with or without MF59 adjuvant. Preimmunization and 4-week post-immunization sera underwent strain-specific hemagglutination inhibition assay. We randomized 73 patients and 67 (35 adjuvanted; 32 non-adjuvanted) had paired samples available at follow-up...
March 6, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28251891/mid-season-real-time-estimates-of-seasonal-influenza-vaccine-effectiveness-in-persons-65-years-and-older-in-register-based-surveillance-stockholm-county-sweden-and-finland-january-2017
#15
Maria-Pia Hergens, Ulrike Baum, Mia Brytting, Niina Ikonen, Anu Haveri, Åsa Wiman, Hanna Nohynek, Åke Örtqvist
Systems for register-based monitoring of vaccine effectiveness (VE) against laboratory-confirmed influenza (LCI) in real time were set up in Stockholm County, Sweden, and Finland, before start of the 2016/17 influenza season, using population-based cohort studies. Both in Stockholm and Finland, an early epidemic of influenza A(H3N2) peaked in week 52, 2016. Already during weeks 48 to 50, analyses of influenza VE in persons 65 years and above showed moderately good estimates of around 50%, then rapidly declined by week 2, 2017 to 28% and 32% in Stockholm and Finland, respectively...
February 23, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28207689/interim-estimates-of-2016-17-seasonal-influenza-vaccine-effectiveness-united-states-february-2017
#16
Brendan Flannery, Jessie R Chung, Swathi N Thaker, Arnold S Monto, Emily T Martin, Edward A Belongia, Huong Q McLean, Manjusha Gaglani, Kempapura Murthy, Richard K Zimmerman, Mary Patricia Nowalk, Michael L Jackson, Lisa A Jackson, Angie Foust, Wendy Sessions, LaShondra Berman, Sarah Spencer, Alicia M Fry
In the United States, annual vaccination against seasonal influenza is recommended for all persons aged ≥6 months (1). Each influenza season since 2004-05, CDC has estimated the effectiveness of seasonal influenza vaccine to prevent influenza-associated, medically attended, acute respiratory illness (ARI). This report uses data, as of February 4, 2017, from 3,144 children and adults enrolled in the U.S. Influenza Vaccine Effectiveness Network (U.S. Flu VE Network) during November 28, 2016-February 4, 2017, to estimate an interim adjusted effectiveness of seasonal influenza vaccine for preventing laboratory-confirmed influenza virus infection associated with medically attended ARI...
February 17, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28205503/interim-estimates-of-2016-17-vaccine-effectiveness-against-influenza-a-h3n2-canada-january-2017
#17
Danuta M Skowronski, Catharine Chambers, Suzana Sabaiduc, James A Dickinson, Anne-Luise Winter, Gaston De Serres, Steven J Drews, Agatha Jassem, Jonathan B Gubbay, Hugues Charest, Robert Balshaw, Nathalie Bastien, Yan Li, Mel Krajden
Using a test-negative design, the Canadian Sentinel Practitioner Surveillance Network (SPSN) assessed interim 2016/17 influenza vaccine effectiveness (VE) against dominant influenza A(H3N2) viruses considered antigenically matched to the clade 3C.2a vaccine strain. Sequence analysis revealed substantial heterogeneity in emerging 3C.2a1 variants by province and over time. Adjusted VE was 42% (95% confidence interval: 18-59%) overall, with variation by province. Interim virological and VE findings reported here warrant further investigation to inform potential vaccine reformulation...
February 9, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/27929223/acip-updates-influenza-vaccination-recommendations-for-2016-2017
#18
Carrie Armstrong
No abstract text is available yet for this article.
October 15, 2016: American Family Physician
https://www.readbyqxmd.com/read/27882801/rapid-assessment-of-the-reactogenicity-of-a-2016-2017-seasonal-influenza-vaccine-results-from-a-feasibility-study
#19
Anke L Stuurman, Thomas Verstraeten, Antoon De Schryver
BACKGROUND: ​​The European Medicines Agency (EMA) calls for a strategy for enhanced safety surveillance of seasonal influenza vaccines. OBJECTIVE: We assessed the feasibility of collecting reactogenicity data within one month of the start of the vaccination campaign in Belgium. METHODS: One hundred subjects aged 18 to 65 years who had received inactivated seasonal influenza vaccine in occupational setting were enrolled. For 7 days after vaccination, subjects received a daily SMS with a link to a web-based questionnaire where reactogenicity events and their severity were solicited...
February 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/27824536/influenza-still-more-important-than-zika-virus-in-2016-2017
#20
REVIEW
Sherif Beniameen Mossad
Influenza kills and hospitalizes many people every year. Although the 2015-2016 influenza season was relatively mild, we should remain vigilant in our efforts to reduce the impact of future epidemics or pandemics by implementing universal influenza vaccination and early initiation of antiviral therapy for suspected cases. We don't expect influenza vaccine to prevent all cases of influenza, since immune response varies depending on age, underlying diseases, and immunosuppression.
November 2016: Cleveland Clinic Journal of Medicine
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