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Influenza vaccine 2016-2017

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https://www.readbyqxmd.com/read/29189713/low-prevalence-of-enzootic-equine-influenza-virus-among-horses-in-mongolia
#1
Alexandra Sack, Ulziimaa Daramragchaa, Maitsetseg Chuluunbaatar, Battsetseg Gonchigoo, Boldbaatar Bazartseren, Nyamdorj Tsogbadrakh, Gregory C Gray
Horses are critically important for Mongolian herders' livelihoods, providing transportation and food products, and playing important cultural roles. Equine influenza virus (EIV) epizootics have been frequent among Mongolia's horses, with five occurring since 1970. We sought to estimate the prevalence for EIV infection among horses and Bactrian camels with influenza-like illness between national epizootics. In 2016-2017, active surveillance for EIV was periodically performed in four aimags (provinces). Nasal swabs were collected from 680 horses and 131 camels...
November 30, 2017: Pathogens
https://www.readbyqxmd.com/read/29167344/comparison-of-the-efficacy-of-n9-neuraminidase-specific-monoclonal-antibodies-against-influenza-a-h7n9-virus-infection
#2
Hongquan Wan, Li Qi, Jin Gao, Laura K Couzens, Lianlian Jiang, Yamei Gao, Zong-Mei Sheng, Sharon Fong, Megan Hahn, Surender Khurana, Jeffery K Taubenberger, Maryna C Eichelberger
The fifth wave of A(H7N9) virus infection in China from 2016 to 2017 caused great concern due to the large number of individuals infected, the isolation of drug-resistant viruses and emergence of highly pathogenic strains. Antibodies against neuraminidase (NA) provide added benefit to hemagglutinin-specific immunity and may be an important contributor to the effectiveness of A(H7N9) vaccines. We generated a panel of mouse monoclonal antibodies (MAbs) to identify antigenic domains on NA of the novel A(H7N9) virus and compared their functional properties...
November 22, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29145568/seasonal-influenza-vaccine-effectiveness-in-preventing-laboratory-confirmed-influenza-in-primary-care-in-israel-2016-2017-season-insights-into-novel-age-specific-analysis
#3
Yaniv Stein, Michal Mandelboim, Hanna Sefty, Rakefet Pando, Ella Mendelson, Tamy Shohat, Aharona Glatman-Freedman
Background: The 2016-2017 influenza season in Israel was dominated by the circulation of influenza A(H3N2). Influenza vaccine is recommended for the entire population in Israel over the age of six months. The inactivated influenza vaccine was chosen for use this season. Methods: We estimated the 2016-2017 end-of-season influenza vaccine effectiveness (VE) in preventing influenza-like illness (ILI) due to influenza A(H3N2), using the test-negative design. Age-specific VE was estimated using a moving age window and weekly analysis...
November 14, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29128383/influenza-vaccination-in-preventing-outbreaks-in-schools-a-long-term-ecological-overview
#4
Yang Pan, Quanyi Wang, Peng Yang, Li Zhang, Shuangsheng Wu, Yi Zhang, Ying Sun, Wei Duan, Chunna Ma, Man Zhang, Xingxing Zhang, C Raina MacIntyre
Influenza vaccination is the most effective way to reduce the incidence of influenza infections. However, the role of influenza vaccination, such as school-based influenza vaccination, in preventing the influenza outbreaks in schools remains unclear now. In this study, a total of 286 school febrile outbreaks involving 6863 cases in the Beijing area from September 1, 2006 to March 31, 2017 were analyzed. We also tested 294 circulating strains isolated in Beijing during the same period and compared with that of vaccine strains identified every influenza season...
November 8, 2017: Vaccine
https://www.readbyqxmd.com/read/29114729/cost-effectiveness-of-strategies-for-offering-influenza-vaccine-in-the-pediatric-emergency-department
#5
Rebecca J Hart, Michelle D Stevenson, Michael J Smith, A Scott LaJoie, Keith Cross
Importance: Influenza is a significant public health burden, causing morbidity and mortality in children, yet vaccination rates remain low. Vaccination in the pediatric emergency department (PED) setting may be beneficial but, to date, has not been proven to be cost-effective. Objective: To compare the cost-effectiveness of 4 strategies for PED-based influenza vaccine: offering vaccine to all patients, only to patients younger than 5 years, only to high-risk patients (all ages), or to no patients...
November 6, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/29112488/immunogenicity-and-safety-of-a-novel-seasonal-influenza-preservative-free-vaccine-manufactured-in-kazakhstan-results-of-a-comparative-phase-ii-clinical-trial-in-adults
#6
Gulbanu Sarsenbayeva, Yevgeniy Volgin, Markhabat Kassenov, Timur Issagulov, Nikolay Bogdanov, Abylay Sansyzbay, Marina Stukova, Zhanna Buzitskaya, Ilyas Кulmagambetov, Timur Davlyatshin, Berik Khairullin
BACKGROUND: The study was aimed at comparative evaluation of seasonal influenza vaccine RIBSP versus commercial vaccine VAXIGRIP® for immunogenicity and safety in the course of clinical trial phase II on healthy volunteers aged 18-60 years. METHODS: The trial involved 150 subjects in randomized 2:1 groups that received either RIBSP vaccine or comparator vaccine VAXIGRIP®. One dose (0.5 ml) of either vaccine contained 15 μg of hemagglutinin of each influenza virus strain recommended by WHO for the Northern hemisphere in 2016-2017 flu season...
November 7, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29109276/contemporary-h3n2-influenza-viruses-have-a-glycosylation-site-that-alters-binding-of-antibodies-elicited-by-egg-adapted-vaccine-strains
#7
Seth J Zost, Kaela Parkhouse, Megan E Gumina, Kangchon Kim, Sebastian Diaz Perez, Patrick C Wilson, John J Treanor, Andrea J Sant, Sarah Cobey, Scott E Hensley
H3N2 viruses continuously acquire mutations in the hemagglutinin (HA) glycoprotein that abrogate binding of human antibodies. During the 2014-2015 influenza season, clade 3C.2a H3N2 viruses possessing a new predicted glycosylation site in antigenic site B of HA emerged, and these viruses remain prevalent today. The 2016-2017 seasonal influenza vaccine was updated to include a clade 3C.2a H3N2 strain; however, the egg-adapted version of this viral strain lacks the new putative glycosylation site. Here, we biochemically demonstrate that the HA antigenic site B of circulating clade 3C...
November 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29077424/surveillance-snapshot-influenza-vaccine-effectiveness-u-s-european-command-as-estimated-by-the-department-of-defense-global-laboratory-based-influenza-surveillance-program-2016-2017-influenza-season
#8
https://www.readbyqxmd.com/read/29043961/low-2016-17-season-vaccine-effectiveness-against-hospitalised-influenza-a-h3n2-among-elderly-awareness-warranted-for-2017-18-season
#9
Marc Rondy, Alin Gherasim, Itziar Casado, Odile Launay, Caterina Rizzo, Daniela Pitigoi, Aukse Mickiene, Sierk D Marbus, Ausenda Machado, Ritva K Syrjänen, Iva Pem-Novose, Judith Krisztina Horváth, Amparo Larrauri, Jesús Castilla, Philippe Vanhems, Valeria Alfonsi, Alina E Ivanciuc, Monika Kuliese, Rianne van Gageldonk-Lafeber, Veronica Gomez, Niina Ikonen, Zvjezdana Lovric, Annamária Ferenczi, I-Move Hospital Working Group, Alain Moren
In a multicentre European hospital study we measured influenza vaccine effectiveness (IVE) against A(H3N2) in 2016/17. Adjusted IVE was 17% (95% confidence interval (CI): 1 to 31) overall; 25% (95% CI: 2 to 43) among 65-79-year-olds and 13% (95% CI: -15 to 30) among those ≥ 80 years. As the A(H3N2) vaccine component has not changed for 2017/18, physicians and public health experts should be aware that IVE could be low where A(H3N2) viruses predominate.
October 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29037978/expected-immunizations-and-health-protection-for-hajj-and-umrah-2018-an-overview
#10
REVIEW
Jaffar A Al-Tawfiq, Philippe Gautret, Ziad A Memish
BACKGROUND: The annual Hajj and Umrah are one of the largest recurring religious mass gatherings across the globe drawing pilgrims from more than 185 countries. The living circumstances and activities of the pilgrims may create an environment for the occurrence and spread of communicable diseases. Each year, the Health authority of the Kingdom of Saudi Arabia, in coordination with international health authorities, updates health requirements for pilgrims. The Hajj for 2017 took place from August 24 to September 5, 2017...
October 14, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29020179/the-household-influenza-vaccine-effectiveness-study-lack-of-antibody-response-and-protection-following-receipt-of-2014-2015-influenza-vaccine
#11
Joshua G Petrie, Ryan E Malosh, Caroline K Cheng, Suzanne E Ohmit, Emily T Martin, Emileigh Johnson, Rachel Truscon, Maryna C Eichelberger, Larisa V Gubareva, Alicia M Fry, Arnold S Monto
Background: Antigenically drifted A(H3N2) viruses circulated extensively during the 2014-2015 influenza season. Vaccine effectiveness (VE) was low and not significant among outpatients but in a hospitalized population was 43%. At least one study paradoxically observed increased A(H3N2) infection among those vaccinated 3 consecutive years. Methods: We followed a cohort of 1341 individuals from 340 households. VE against laboratory-confirmed influenza was estimated...
July 20, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28986441/changes-in-influenza-vaccination-rates-after-withdrawal-of-live-vaccine
#12
Steve G Robison, Aaron G Dunn, Deborah L Richards, Richard F Leman
BACKGROUND: Before the start of the 2016-2017 influenza season, the Advisory Committee on Immunization Practices withdrew its recommendation promoting the use of live attenuated influenza vaccines (LAIVs). There was concern that this might lessen the likelihood that those with a previous LAIV would return for an injectable influenza vaccine (IIV) and that child influenza immunization rates would decrease overall. METHODS: Using Oregon's statewide immunization registry, the ALERT Immunization Information System, child influenza immunization rates were compared across the 2012-2013 through 2016-2017 seasons...
November 2017: Pediatrics
https://www.readbyqxmd.com/read/28957044/influenza-vaccination-coverage-among-pregnant-women-united-states-2016-17-influenza-season
#13
Helen Ding, Carla L Black, Sarah Ball, Rebecca V Fink, Walter W Williams, Amy Parker Fiebelkorn, Peng-Jun Lu, Katherine E Kahn, Denise V D'Angelo, Rebecca Devlin, Stacie M Greby
Pregnant women and their infants are at increased risk for severe influenza-associated illness (1), and since 2004, the Advisory Committee on Immunization Practices (ACIP) has recommended influenza vaccination for all women who are or might be pregnant during the influenza season, regardless of the trimester of the pregnancy (2). To assess influenza vaccination coverage among pregnant women during the 2016-17 influenza season, CDC analyzed data from an Internet panel survey conducted during March 28-April 7, 2017...
September 29, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28956803/infant-immunization-coverage-in-italy-2000-2016
#14
Carlo Signorelli, Anna Odone, Paola Cella, Stefania Iannazzo, Fortunato D'Ancona, Raniero Guerra
BACKGROUND: In Italy, national-level immunization polices are included in the National Immunization Prevention Plan (PNPV), whose latest edition - 2017-2019 PNPV - was finally approved in February 2017. Coverage rates are a key measure of immunization system performance; it can inform and support national and regional polices' implementation monitoring, as well as measure the impact of interventions aimed at increasing vaccine uptake. METHODS: We collected, analysed and critically interpreted 2000-2016 Italian national infant immunization coverage trends, by different vaccine, target population, and by Region...
July 2017: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/28945700/perspectives-from-the-society-for-pediatric-research-spr-decreased-effectiveness-of-the-live-attenuated-influenza-vaccine-laiv
#15
REVIEW
Michelle A Gill, Elizabeth P Schlaudecker
Purpose of SPR Perspectives Reviews: Address contemporary scientific issues and controversies by leveraging the expertise of SPR membersIncrease SPR member engagement with the journalPair established and younger SPR members to simultaneously increase interaction between SPR members and create opportunities for mentorship The intranasal Live Attenuated Influenza Vaccine (LAIV), FluMist, has been widely appreciated by pediatricians, parents and children alike for its ease of administration. Concerns regarding lack of effectiveness in recent influenza seasons, however, led to the CDC Advisory Committee on Immunization Practices (ACIP) recommendation to administer inactivated influenza vaccines (IIV), and not LAIV, during the 2016-17 and 2017-18 seasons...
September 25, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28895750/brief-report-mid-season-influenza-vaccine-effectiveness-estimates-for-the-2016-2017-influenza-season
#16
Elizabeth Toure, Angelia A Eick-Cost, Anthony W Hawksworth, Michael J Cooper, Zheng Hu, Christopher A Myers, Peter E Kammerer, Michelle N Ricketts, Susan Federinko
No abstract text is available yet for this article.
August 2017: MSMR
https://www.readbyqxmd.com/read/28890192/workplace-availability-risk-group-and-perceived-barriers-predictive-of-2016-17-influenza-vaccine-uptake-in-the-united-states-a-cross-sectional-study
#17
Paula M Luz, Riley E Johnson, Heidi E Brown
BACKGROUND: Seasonal influenza, though mostly self-limited in the healthy adult, may lead to severe disease and/or complications in subpopulations. Annual influenza vaccination is available in many countries with coverage goals rarely being met. We conducted a cross-sectional study of influenza vaccine uptake and explored socio-demographic, economic, and psychological factors that explained vaccine uptake. METHODS: The survey was administered via Amazon Mechanical Turk (MTurk) to United States residents in January 2017, using the Qualtrics platform...
September 7, 2017: Vaccine
https://www.readbyqxmd.com/read/28880856/update-increase-in-human-infections-with-novel-asian-lineage-avian-influenza-a-h7n9-viruses-during-the-fifth-epidemic-china-october-1-2016-august-7-2017
#18
James C Kile, Ruiqi Ren, Liqi Liu, Carolyn M Greene, Katherine Roguski, A Danielle Iuliano, Yunho Jang, Joyce Jones, Sharmi Thor, Ying Song, Suizan Zhou, Susan C Trock, Vivien Dugan, David E Wentworth, Min Z Levine, Timothy M Uyeki, Jacqueline M Katz, Daniel B Jernigan, Sonja J Olsen, Alicia M Fry, Eduardo Azziz-Baumgartner, C Todd Davis
Among all influenza viruses assessed using CDC's Influenza Risk Assessment Tool (IRAT), the Asian lineage avian influenza A(H7N9) virus (Asian H7N9), first reported in China in March 2013,* is ranked as the influenza virus with the highest potential pandemic risk (1). During October 1, 2016-August 7, 2017, the National Health and Family Planning Commission of China; CDC, Taiwan; the Hong Kong Centre for Health Protection; and the Macao CDC reported 759 human infections with Asian H7N9 viruses, including 281 deaths, to the World Health Organization (WHO), making this the largest of the five epidemics of Asian H7N9 infections that have occurred since 2013 (Figure 1)...
September 8, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28877235/genetic-and-antigenic-characterization-of-influenza-a-h3n2-in-cameroon-during-the-2014-2016-influenza-seasons
#19
Gwladys C Monamele, Marie-Astrid Vernet, Mohammed R Njankouo, Kathleen Victoir, Jane Francis Akoachere, Damian Anong, Richard Njouom
The first outbreak of influenza A(H3N2) occurred in 1968 and caused the third flu pandemic of the 20th century. It has affected multiple countries over time. The best strategy to reduce the burden of influenza is through vaccination whose efficacy varies with respect to the circulating strains. This study was performed to better understand the molecular evolution of influenza A(H3N2) and assess vaccine efficacy in Cameroon. Complete sequences of three gene segments were obtained from 2014 to 2016 influenza seasons in Cameroon...
2017: PloS One
https://www.readbyqxmd.com/read/28870977/recommendations-for-prevention-and-control-of-influenza-in-children-2017-2018
#20
(no author information available yet)
This statement updates the recommendations for routine use of the seasonal influenza vaccine and antiviral medications for the prevention and treatment of influenza in children. The American Academy of Pediatrics recommends annual seasonal influenza immunization for everyone 6 months and older, including children and adolescents. Highlights for the upcoming 2017-2018 season include the following:1. Annual universal influenza immunization is indicated with either a trivalent or quadrivalent (no preference) inactivated vaccine;2...
October 2017: Pediatrics
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