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Brain tumor related epilepsy

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https://www.readbyqxmd.com/read/29566708/seizures-in-children-with-neurofibromatosis-type-1-is-neurofibromatosis-type-1-enough
#1
Claudia Santoro, Pia Bernardo, Antonietta Coppola, Umberto Pugliese, Mario Cirillo, Teresa Giugliano, Giulio Piluso, Giuseppe Cinalli, Salvatore Striano, Carmela Bravaccio, Silverio Perrotta
BACKGROUND: Neurofibromatosis type 1 (NF1) is related to a generally increased prevalence of seizures. The mechanism underlying the increased predisposition to seizures has not been fully elucidated. The aim of the study was to evaluate the role of NF1 in seizures pathogenesis in a cohort of children with NF1 and seizures. METHODS: The medical records of 437 children (0-18 years old) with NF1 were reviewed. All children with at least one afebrile seizure were included...
March 22, 2018: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29554343/stereoelectroencephalography-guided-laser-ablations-in-patients-with-neocortical-pharmacoresistant-focal-epilepsy-concept-and-operative-technique
#2
Louis Ross, Ahsan M Naduvil, Juan C Bulacio, Imad M Najm, Jorge A Gonzalez-Martinez
BACKGROUND: Laser ablation surgery has had encouraging results in the treatment of multiple intracranial diseases including primary and metastatic brain tumors, radiation necrosis, and epilepsy. The use of the stereoelectroencephalography (SEEG) method in combination with laser thermocoagulation therapy with the goal of modulating epileptic networks in patients with neocortical nonlesional phamacoresistant epilepsy has not been previously described. OBJECTIVE: To describe the novel methodological and conceptual aspects related to SEEG-guided laser ablations in patients with magnetic resonance imaging (MRI)-negative pharmacoresistant neocortical focal epilepsy...
March 14, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29490917/high-frequency-oscillations-in-awake-patients-undergoing-brain-tumor-related-epilepsy-surgery
#3
Anteneh M Feyissa, Gregory A Worrell, William O Tatum, Deependra Mahato, Benjamin H Brinkmann, Steven S Rosenfeld, Karim ReFaey, Perry S Bechtle, Alfredo Quinones-Hinojosa
OBJECTIVE: To examine the relationship between high-frequency oscillations (HFOs) and the presence of preoperative seizures, World Health Organization tumor grade, and isocitrate dehydrogenase 1 (IDH1) mutational status in gliomas. METHODS: We retrospectively studied intraoperative electrocorticography recorded in 16 patients with brain tumor (12 presenting with seizures) who underwent awake craniotomy and surgical resection between September 2016 and June 2017...
February 28, 2018: Neurology
https://www.readbyqxmd.com/read/29477544/cerebral-microvascular-abnormalities-in-patients-with-idiopathic-intracranial-hypertension
#4
Vigdis Andersen Eidsvaag, Hans-Arne Hansson, Kjell Heuser, Erlend A Nagelhus, Per Kristian Eide
AIM: Idiopathic intracranial hypertension (IIH) is characterized by symptoms indicative of increased intracranial pressure (ICP), such as headache and visual impairment. We have previously reported that brain biopsies from IIH patients show patchy astrogliosis and increased expression of the water channel aquaporin-4 (AQP4) at perivascular astrocytic endfeet. METHODS: The present study was undertaken to investigate for ultrastructural changes of the cerebral capillaries in individuals with IIH...
February 22, 2018: Brain Research
https://www.readbyqxmd.com/read/29386275/risk-for-injuries-and-accidents-in-epilepsy-a-prospective-population-based-cohort-study
#5
Benno Mahler, Sofia Carlsson, Tomas Andersson, Torbjörn Tomson
OBJECTIVE: To study the risk for injuries/accidents in people with newly diagnosed epileptic seizures in relation to comorbidities. METHODS: Between September 1, 2001, and August 31, 2008, individuals in northern Stockholm with incident unprovoked seizures (epilepsy; n = 2,130) were included in a registry. For every epilepsy patient, 8 individuals matched for sex and inclusion year (n = 16,992) were randomly selected as references from the population of the catchment area...
February 27, 2018: Neurology
https://www.readbyqxmd.com/read/29385923/high-intensity-focused-ultrasound-past-present-and-future-in-neurosurgery
#6
Syed A Quadri, Muhammad Waqas, Inamullah Khan, Muhammad Adnan Khan, Sajid S Suriya, Mudassir Farooqui, Brian Fiani
Since Lynn and colleagues first described the use of focused ultrasound (FUS) waves for intracranial ablation in 1942, many strides have been made toward the treatment of several brain pathologies using this novel technology. In the modern era of minimal invasiveness, high-intensity focused ultrasound (HIFU) promises therapeutic utility for multiple neurosurgical applications, including treatment of tumors, stroke, epilepsy, and functional disorders. Although the use of HIFU as a potential therapeutic modality in the brain has been under study for several decades, relatively few neuroscientists, neurologists, or even neurosurgeons are familiar with it...
February 2018: Neurosurgical Focus
https://www.readbyqxmd.com/read/29313510/need-for-surgical-treatment-of-epilepsy-and-excision-of-tumors-and-post-traumatic-epileptogenic-lesions-in-kinshasa-rdc
#7
G Ntsambi-Eba, A Beltchika Kalubye, J P Kalala Okito
Surgery is a treatment to consider in epilepsy when the condition is refractory or epileptic events are related to a clearly identified brain abnormality. The tropical climate of the DRC explains the high risk of epilepsy and the potentially large number of refractory cases. The number of patients with epilepsy in Kinshasa is estimated to be at least 120 000, and almost one third may be refractory. Hence, the need to integrate the use of surgery in the treatment of this disease. Most neurosurgical techniques used for treating epilepsy are practiced with a neurosurgical microscope and neuronavigation...
November 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/29288854/lesional-temporal-lobe-epilepsy-beware-the-deceitful-panic-attack
#8
Kay O Kulason, Julia R Schneider, Ralph Rahme, Bidyut Pramanik, Derek Chong, John A Boockvar
BACKGROUND: Ganglioglioma is a rare, benign, intraaxial glioneuronal tumor but a relatively common cause of pharmacoresistant temporal lobe epilepsy (TLE). Given its often nonspecific neuropsychiatric manifestations and frequently negative electroencephalographic workup, TLE can be easily misdiagnosed as a psychiatric disorder, particularly panic attacks. CASE DESCRIPTION: We present a case of a 17-year-old boy who was found to have lesional TLE secondary to a left temporal ganglioglioma, 5 years after having been misdiagnosed with panic disorder and having undergone ineffective and unnecessary psychotherapy...
March 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29249552/pretreatment-cognition-in-patients-diagnosed-with-pediatric-brain-tumors
#9
Elin Irestorm, Sean Perrin, Ingrid Tonning Olsson
BACKGROUND: There is a large body of literature identifying risk factors for the long-term cognitive alterations found in survivors of pediatric brain tumors. Less is known about baseline cognitive functioning in this population, but studies suggest that cognitive dysfunctions are often present at the time of diagnosis. This study aimed to identify potential risk factors for lower cognitive function at the time of pediatric brain tumor diagnosis. METHODS: Participants were children and adolescents (n = 101) diagnosed with a pediatric brain tumor between 2006 and 2015, who underwent a pretreatment neuropsychologic assessment...
February 2018: Pediatric Neurology
https://www.readbyqxmd.com/read/29226043/applications-of-whole-brain-tractography-and-implications-for-clinical-practice
#10
REVIEW
Brian W Wu, Stephanie Barr
The complicated nature of neurological diseases-and the importance of accurate diagnosis and treatment for patient quality of life-have made the need for more advanced imaging techniques more urgent than ever. Automated whole brain tractography promises to increase the knowledge that neurologists have of a variety of disease processes, including schizophrenia, age-related changes to white matter, brain tumors, and epilepsy.
October 5, 2017: Curēus
https://www.readbyqxmd.com/read/29200115/medical-complications-of-brain-tumors
#11
Nimish A Mohile
PURPOSE OF REVIEW: This article discusses common and emergent medical complications encountered in patients with primary brain tumors. RECENT FINDINGS: Clinical studies and systematic reviews published in recent years have improved knowledge regarding the incidence of neurologic and medical complications occurring in patients with primary brain tumors. Studies in tumor-related epilepsy and venous thromboembolism provide data for the clinician to make evidence-based decisions about perioperative management, prophylaxis, and therapy...
December 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/29116582/late-onset-first-episode-psychosis-emerging-as-delusional-misidentification-of-familiar-sacred-places-during-a-holy-pilgrimage-a-case-report-and-literature-review
#12
Mahmoud A Awara, Hamdy F Moselhy, Manal O Elnenaei
BACKGROUND: The delusional misidentification syndromes (DMS) include a myriad of discrete but related syndromes, which have wide spectrum anomalies of familiarity. Several misidentification syndromes have been described in the psychiatric literature, the most common of these delusions are: the Capgras syndrome; the Fregoli syndrome; the syndrome of inter-metamorphosis; reduplicative paramnesia; and environmental reduplication. CASE PRESENTATION: The reported case highlights the emergence of late onset first episode psychosis in a Middle Eastern 65-year-old female who has no previous psychiatric history...
November 7, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/29112665/long-term-risk-of-a-seizure-disorder-after-eclampsia
#13
Kara A Nerenberg, Alison L Park, Simone N Vigod, Gustavo Saposnik, Howard Berger, Michelle A Hladunewich, Shital Gandhi, Candice K Silversides, Joel G Ray
OBJECTIVE: To evaluate the incidence rate and relative risk of a seizure disorder after eclampsia. METHODS: We evaluated 1,565,733 births in a retrospective data linkage cohort study in Ontario, Canada, from April 1, 2002, to March 31, 2014. We included females aged 15-50 years and excluded patients with epilepsy, conditions predisposing to seizure, and those who died within 30 days of the delivery discharge date. The exposure was defined as a hypertensive disorder of pregnancy, namely 1) eclampsia, 2) preeclampsia, or 3) gestational hypertension...
December 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29099300/diagnostic-value-of-preoperative-inflammatory-markers-in-patients-with-glioma-a-multicenter-cohort-study
#14
Shi-Hao Zheng, Jin-Lan Huang, Ming Chen, Bing-Long Wang, Qi-Shui Ou, Sheng-Yue Huang
OBJECTIVE Glioma is the most common form of brain tumor and has high lethality. The authors of this study aimed to elucidate the efficiency of preoperative inflammatory markers, including neutrophil/lymphocyte ratio (NLR), derived NLR (dNLR), platelet/lymphocyte ratio (PLR), lymphocyte/monocyte ratio (LMR), and prognostic nutritional index (PNI), and their paired combinations as tools for the preoperative diagnosis of glioma, with particular interest in its most aggressive form, glioblastoma (GBM). METHODS The medical records of patients newly diagnosed with glioma, acoustic neuroma, meningioma, or nonlesional epilepsy at 3 hospitals between January 2011 and February 2016 were collected and retrospectively analyzed...
November 3, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29083341/a-case-of-refractary-epilepsy-and-related-pain-due-to-dysmenorrhea-solved-with-loading-dose-of-lacosamide-clinical-and-neurophysiological-correlates
#15
Nicolino Marchitto, Umberto Ceratti, Serenella Dalmaso, Gianfranco Raimondi
 In most cases, the etiology of epilepsy is unknown, although some individuals may develop epilepsy as a result of certain brain injuries, following a stroke, a brain tumor or because of drugs and alcohol. Even some rare genetic mutations may be related to the onset of the condition. Seizures are the result of excessive and abnormal activity of neurons in the cerebral cortex. In this case report we show a clinical case of refractory epilepsy due to pain related to uncontrolled dysmenorrhea. The patient, 43 yrs old, had a history of epilepsy of 20 years and ovarian cancer...
October 23, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29063814/the-use-of-cannabidiol-for-seizure-management-in-patients-with-brain-tumor-related-epilepsy
#16
Paula Province Warren, E Martina Bebin, L Burt Nabors, Jerzy P Szaflarski
Epilepsy, commonly encountered by patients with brain tumors, is often refractory to standard therapies. Our aim was to examine the safety and efficacy of pharmaceutical grade cannabidiol (CBD; Epidiolex; Greenwich Biosciences) in those patients with epilepsy with concomitant tumors enrolled in The University of Alabama at Birmingham CBD Program (NCT02700412 and NCT02695537). Of the three patients with refractory seizures and a history of a primary brain tumor, two had improvement in seizure frequency and all three had improvement in seizure severity...
October 2017: Neurocase
https://www.readbyqxmd.com/read/29062690/paroxysmal-dysphasia-in-a-68-year-old-man-enhancing-the-mri-spectrum
#17
Ugur Sener, William O Tatum, Alfredo Quinones-Hinojosa, Deependra Mahato, Anteneh M Feyissa
Brain tumor-related epilepsy is a common complication of primary and metastatic brain tumors with seizures often representing the first manifestation of the tumor. The size and location of the tumor can make detection of epileptiform discharges on scalp electroencephalogram and safe surgical resection challenging. We describe a case of a patient with glioblastoma multiforme presenting as dominant temporal lobe epilepsy. Seizures were manifest as episodes of speech arrest on a background of long-standing history of episodic speech difficulty and headache...
2017: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/29023170/ampa-receptors-and-perampanel-behind-selected-epilepsies-current-evidence-and-future-perspectives
#18
Carlo Di Bonaventura, Angelo Labate, Marta Maschio, Stefano Meletti, Emilio Russo
The alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors are the major mediators of glutamate-mediated excitatory neurotransmission, and are critical for synchronization and spread of epileptic activity. Areas covered: AMPA receptor antagonists have been also developed as antiepileptic drugs and perampanel (PER) is the first highly selective, non-competitive AMPA-type glutamate receptor antagonist that is available on the market. It is approved as adjunctive therapy for the treatment of partial-onset seizures with or without secondary generalization, and for primary generalized tonic-clonic seizures in idiopathic generalized epilepsy, in patients aged ≥ 12 years...
November 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28984519/surgical-management-of-incidentally-discovered-diffusely-infiltrating-low-grade-glioma
#19
Michael Opoku-Darko, Stefan T Lang, James Artindale, J Gregory Cairncross, Robert J Sevick, John J P Kelly
OBJECTIVE Occasionally, diffusely infiltrating low-grade gliomas (LGGs) are identified as incidental findings in patients who have no signs or symptoms that can be ascribed to the tumors. The diagnosis of incidental, asymptomatic LGGs has become more frequent due to the vast increase in access to medical imaging technology. While management of these lesions remains controversial, early surgery has been suggested to improve outcome. The authors set out to identify and review the characteristics and surgical outcomes of patients who underwent surgical intervention for incidental LGG...
October 6, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28963765/antiepileptic-drug-related-neuropsychiatric-adverse-events-in-brain-tumor-related-epilepsy-levetiracetam-front-and-center
#20
EDITORIAL
A M Feyissa
No abstract text is available yet for this article.
December 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
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