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Brain tumor related epilepsy

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https://www.readbyqxmd.com/read/29023170/ampa-receptors-and-perampanel-behind-selected-epilepsies-current-evidence-and-future-perspectives
#1
Carlo Di Bonaventura, Angelo Labate, Marta Maschio, Stefano Meletti, Emilio Russo
The alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors are the major mediators of glutamate-mediated excitatory neurotransmission, and are critical for synchronization and spread of epileptic activity. Areas covered. AMPA receptor antagonists have been also developed as antiepileptic drugs and perampanel (PER) is the first highly selective, non-competitive AMPA-type glutamate receptor antagonist that is available on the market. It is approved as adjunctive therapy for the treatment of partial-onset seizures with or without secondary generalization, and for primary generalized tonic-clonic seizures in idiopathic generalized epilepsy, in patients aged ≥ 12 years...
October 12, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28984519/surgical-management-of-incidentally-discovered-diffusely-infiltrating-low-grade-glioma
#2
Michael Opoku-Darko, Stefan T Lang, James Artindale, J Gregory Cairncross, Robert J Sevick, John J P Kelly
OBJECTIVE Occasionally, diffusely infiltrating low-grade gliomas (LGGs) are identified as incidental findings in patients who have no signs or symptoms that can be ascribed to the tumors. The diagnosis of incidental, asymptomatic LGGs has become more frequent due to the vast increase in access to medical imaging technology. While management of these lesions remains controversial, early surgery has been suggested to improve outcome. The authors set out to identify and review the characteristics and surgical outcomes of patients who underwent surgical intervention for incidental LGG...
October 6, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28963765/antiepileptic-drug-related-neuropsychiatric-adverse-events-in-brain-tumor-related-epilepsy-levetiracetam-front-and-center
#3
EDITORIAL
A M Feyissa
No abstract text is available yet for this article.
September 30, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28960284/potential-years-lost-and-life-expectancy-in-adults-with-newly-diagnosed-epilepsy
#4
Claudia A Granbichler, Georg Zimmermann, Willi Oberaigner, Giorgi Kuchukhidze, Jean-Pierre Ndayisaba, Alexandra Taylor, Gerhard Luef, Arne C Bathke, Eugen Trinka
OBJECTIVE: Studies using relative measures, such as standardized mortality ratios, have shown that patients with epilepsy have an increased mortality. Reports on more direct and absolute measure such as life expectancy are sparse. We report potential years lost and how life expectancy has changed over 40 years in a cohort of patients with newly diagnosed epilepsy. METHODS: We analyzed life expectancy in a cohort of adult patients diagnosed with definite epilepsy between 1970 and 2010...
September 28, 2017: Epilepsia
https://www.readbyqxmd.com/read/28939541/ganglioglioma-progression-to-combined-anaplastic-ganglioglioma-and-anaplastic-pleomorphic-xanthoastrocytoma-case-report-and-literature-review
#5
A Rosselló, G Plans, N Vidal-Sarró, A Fernández-Coello, A Gabarrós
BACKGROUND: Composite ganglioma and pleomorphic xanthoastrocytoma with anaplastic features in both components is an extremely rare glioneuronal tumor. 5 cases of anaplastic progression in the glioma component have been reported. These tumors generally affect young patients who suffer brain tumor-related epilepsy, are usually located in the temporal lobe or in the cerebellum, and may associate leptomeningeal spreading. Its current optimal treatment consists of maximal safe surgical resection and adjuvant chemoradiotherapy...
September 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28859566/history-of-psychosurgery-at-sainte-anne-hospital-paris-france-through-translational-interactions-between-psychiatrists-and-neurosurgeons
#6
Marc Zanello, Johan Pallud, Nicolas Baup, Sophie Peeters, Baris Turak, Marie Odile Krebs, Catherine Oppenheim, Raphael Gaillard, Bertrand Devaux
Sainte-Anne Hospital is the largest psychiatric hospital in Paris. Its long and fascinating history began in the 18th century. In 1952, it was at Sainte-Anne Hospital that Jean Delay and Pierre Deniker used the first neuroleptic, chlorpromazine, to cure psychiatric patients, putting an end to the expansion of psychosurgery. The Department of Neuro-psychosurgery was created in 1941. The works of successive heads of the Neurosurgery Department at Sainte-Anne Hospital summarized the history of psychosurgery in France...
September 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28832891/outcome-of-cancer-related-seizures-in-patients-treated-with-lacosamide
#7
M Toledo, A Molins, M Quintana, E Santamarina, F Martinez-Ricarte, E Martínez-Saez, J Salas-Puig
OBJECTIVES: Lacosamide is an antiepileptic drug (AED), which has proven to be effective to control seizures, including acute conditions such as status epilepticus. The aim of this study is to describe the clinical experience with lacosamide in neuro-oncological patients. MATERIALS AND METHODS: Multicenter retrospective study in patients with cancer-related seizures, who received lacosamide as an add-on therapy. RESULTS: Forty-eight patients with benign and malignant tumors, including primary brain tumors, lymphomas, systemic cancer with central nervous system involvement, or paraneoplastic encephalitis, were included...
August 22, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28804779/language-mapping-using-t2-prepared-bold-functional-mri-in-the-presence-of-large-susceptibility-artifacts-initial-results-in-patients-with-brain-tumor-and-epilepsy
#8
Jun Hua, Xinyuan Miao, Shruti Agarwal, Chetan Bettegowda, Alfredo Quiñones-Hinojosa, John Laterra, Peter C M Van Zijl, James J Pekar, Jay J Pillai
At present, presurgical functional mapping is the most prevalent clinical application of functional magnetic resonance imaging (fMRI). Signal dropouts and distortions caused by susceptibility effects in the current standard echo planar imaging (EPI)-based fMRI images are well-known problems and pose a major hurdle for the application of fMRI in several brain regions, many of which are related to language mapping in presurgical planning. Such artifacts are particularly problematic in patients with previous surgical resection cavities, craniotomy hardware, hemorrhage, and vascular malformation...
June 2017: Tomography: a Journal for Imaging Research
https://www.readbyqxmd.com/read/28791985/knowledge-of-medical-students-about-epilepsy-need-for-a-change
#9
B A Ezeala-Adikaibe, T Okpara, O S Ekenze, O Onodugo, N P Ezeala-Adikaibe, T Nnaji, G Onyebueke
PURPOSE: Though most doctors in their professional life will provide care for people with epilepsy, many will not get further training in their professional life. There may be other barriers, perceived or not, to providing care to people living with epilepsy by doctors which need to be approached in the medical undergraduate curriculum and medical continuing education. The aim of this study was to determine the knowledge gaps of medical students on basic issues regarding epilepsy that could be useful in preparing training material for the students and continuous medical education for doctors working in the community...
July 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28755329/brain-tumor-related-epilepsy-a-current-review-of-the-etiologic-basis-and-diagnostic-and-treatment-approaches
#10
REVIEW
Jeffrey M Politsky
PURPOSE OF REVIEW: The relationship of brain tumors and seizures remains poorly understood. This article is an overview of the epidemiology, etiology, and diagnostic and treatment approaches of tumor-related epilepsy primarily with regard to glial-based tumors, the most commonly considered brain tumor in this field. RECENT FINDINGS: Over the past many years, several novel etiologic mechanisms to explain how tumors induce seizures have been developed, which this article reviews, including the roles of glutamate-induced excitotoxicity, matrix metalloproteinases, isocitrate dehydrogenase, methylguanine methyltransferase, and functional network connectivity...
September 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28715490/patterns-of-care-of-brain-tumor-related-epilepsy-a-cohort-study-done-in-italian-epilepsy-center
#11
Marta Maschio, Ettore Beghi, Marina M L Casazza, Gabriella Colicchio, Cinzia Costa, Paola Banfi, Stefano Quadri, Paolo Aloisi, Anna Teresa Giallonardo, Carla Buttinelli, Giada Pauletto, Salvatore Striano, Andrea Salmaggi, Riccardo Terenzi, Ornella Daniele, Giovanni Crichiutti, Francesco Paladin, Rosario Rossi, Giulia Prato, Federico Vigevano, Roberto De Simone, Federica Ricci, Marina Saladini, Fabrizio Monti, Susanna Casellato, Tiziano Zanoni, Diana Giannarelli, Giuliano Avanzini, Umberto Aguglia
Epilepsy is the most common comorbidity in patients with brain tumors. STUDY AIMS: To define characteristics of brain tumor-related epilepsy (BTRE) patients and identify patterns of care. Nationwide, multicenter retrospective cohort study. Medical records of BTRE patients seen from 1/1/2010 to 12/31/2011, followed for at least one month were examined. Information included age, sex, tumor type/treatments, epilepsy characteristics, antiepileptic drugs (AEDs). Time to modify first AED due to inefficacy and/or toxicity was assessed with the Kaplan-Meier method and Cox proportional hazard models were used to identify predictors of treatment outcome...
2017: PloS One
https://www.readbyqxmd.com/read/28667867/autophagy-related-protein-expression-was-associated-with-braf-v600e-mutation-in-epilepsy-associated-glioneuronal-tumors
#12
Chun-Hong Shen, Yin-Xi Zhang, Jin-Hong Xu, Qiong-Bin Zhu, Jun-Ming Zhu, Yi Guo, Yao Ding, Shuang Wang, Mei-Ping Ding
PURPOSE: The aim of this study was to explore the expression level of autophagy-related proteins in epileptic patients with glioneuronal tumors (GNTs) and evaluate the association with clinicopathological features. MATERIALS AND METHODS: We obtained the brain specimens from 33 patients with GNTs, including 22 gangliogliomas (GGs) and 11 dysembryoplastic neuroepithelial tumors (DNTs). The expression of two autophagy-related proteins (LC3B and Beclin-1) was evaluated by immunohistochemistry, and BRAF V600E mutation was examined by DNA sequencing...
June 12, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28659752/electrocorticographic-temporal-alteration-mapping-a-clinical-technique-for-mapping-the-motor-cortex-with-movement-related-cortical-potentials
#13
Zehan Wu, Tao Xie, Lin Yao, Dingguo Zhang, Xinjun Sheng, Dario Farina, Liang Chen, Ying Mao, Xiangyang Zhu
We propose electrocorticographic temporal alteration mapping (ETAM) for motor cortex mapping by utilizing movement-related cortical potentials (MRCPs) within the low-frequency band [0.05-3] Hz. This MRCP waveform-based temporal domain approach was compared with the state-of-the-art electrocorticographic frequency alteration mapping (EFAM), which is based on frequency spectrum dynamics. Five patients (two epilepsy cases and three tumor cases) were enrolled in the study. Each patient underwent intraoperative direct electrocortical stimulation (DECS) procedure for motor cortex localization...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28633092/epilepsy-in-neurofibromatosis-type-1
#14
Anthony Pecoraro, Eric Arehart, William Gallentine, Rodney Radtke, Edward Smith, Carolyn Pizoli, Sujay Kansagra, Elie Abdelnour, Roger McLendon, Mohamad A Mikati
OBJECTIVES: To describe the characteristics of epilepsy in patients with Neurofibromatosis type 1 (NF1). METHODS: Analysis of a cohort of consecutive NF1 patients seen in our NF1 clinic during a three-year period. RESULTS: Of the 184 NF1 patients seen during that period, 26 had epilepsy and three had febrile seizures. Of the 26, 17 (65%) had localization-related epilepsy, seven of whom (41%) were drug resistant. Six (23%) had apparently primary generalized epilepsy (0/6 drug resistant), two (8%) Lennox-Gastaut syndrome, and one (4%) West syndrome (all three were drug-resistant)...
August 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28627088/astrogliosis-and-impaired-aquaporin-4-and-dystrophin-systems-in-idiopathic-normal-pressure-hydrocephalus
#15
Per Kristian Eide, Hans-Arne Hansson
AIMS: Idiopathic normal pressure hydrocephalus (iNPH) is one subtype of dementia that may improve following drainage of cerebrospinal fluid (CSF). This prospective observational study explored whether expression of the water channel aquaporin-4 (AQP4) and the anchoring molecule dystrophin 71 (Dp71) are altered at astrocytic perivascular endfeet and in adjacent neuropil of iNPH patient. Observations were related to measurements of pulsatile and static intracranial pressure (ICP). METHODS: The study included iNPH patients undergoing overnight monitoring of the pulsatile/static ICP, in whom a biopsy was taken from the frontal cerebral cortex during placement of the ICP sensor...
June 19, 2017: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/28623754/quality-of-life-mood-and-seizure-control-in-patients-with-brain-tumor-related-epilepsy-treated-with-lacosamide-as-add-on-therapy-a-prospective-explorative-study-with-a-historical-control-group
#16
Marta Maschio, Alessia Zarabla, Andrea Maialetti, Alessandra Fabi, Antonello Vidiri, Veronica Villani, Diana Giannarelli
OBJECTIVE: Brain tumor-related epilepsy (BTRE) is often drug resistant and patients can be forced to take polytherapy that can adversely affect their quality of life (QoL). Lacosamide (LCM) is a new antiepileptic drug (AED) used as adjunctive therapy in patients with partial seizures with or without secondary generalization, with a favorable pharmacokinetic profile that seems to be effective and well tolerated. Therefore it represents a possible therapeutic choice for patients with BTRE...
August 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28616382/improving-language-mapping-in-clinical-fmri-through-assessment-of-grammar
#17
Monika Połczyńska, Kevin Japardi, Susan Curtiss, Teena Moody, Christopher Benjamin, Andrew Cho, Celia Vigil, Taylor Kuhn, Michael Jones, Susan Bookheimer
INTRODUCTION: Brain surgery in the language dominant hemisphere remains challenging due to unintended post-surgical language deficits, despite using pre-surgical functional magnetic resonance (fMRI) and intraoperative cortical stimulation. Moreover, patients are often recommended not to undergo surgery if the accompanying risk to language appears to be too high. While standard fMRI language mapping protocols may have relatively good predictive value at the group level, they remain sub-optimal on an individual level...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28615436/hospital-safety-among-neurologic-patients-a-population-based-cohort-study-of-adverse-events
#18
MULTICENTER STUDY
Khara M Sauro, Hude Quan, Khokan C Sikdar, Peter Faris, Nathalie Jette
OBJECTIVE: To examine the frequency and type of adverse events (AEs) experienced by neurologic patients in hospital. METHODS: This population-based, retrospective cohort study used hospital discharge abstract data for children and adults admitted to hospital from 2009 to 2015 with 1 of 9 neurologic conditions (Alzheimer disease and related dementia, brain tumor, epilepsy, motor neuron disease, multiple sclerosis, parkinsonism/Parkinson disease, spinal cord injury, traumatic brain injury, and stroke)...
July 18, 2017: Neurology
https://www.readbyqxmd.com/read/28599984/prevention-and-management-of-postoperative-seizures-in-neuro-oncology
#19
F Chassoux, E Landre
INTRODUCTION: Epilepsy related to brain tumors is often difficult to treat and may impact the quality of life. We performed a review of current recommendations for the prevention of postoperative seizures and optimizing the anti-epileptic treatment. MATERIAL AND METHODS: Based on studies performed since 2000 we conducted the review by (1) analyzing the incidence of tumoral epilepsy and mechanisms of epileptogenicity; (2) describing the current medical and surgical strategy according to oncologic treatments; (3) discussing the management of postoperative seizures; (4) considering the drug withdrawal after oncologic therapy...
June 6, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28552700/analysis-of-factors-related-to-hypopituitarism-in-patients-with-nonsellar-intracranial-tumor
#20
Song-Song Lu, Jian-Jun Gu, Xiao-Hong Luo, Jian-He Zhang, Shou-Sen Wang
OBJECTIVE: Previous studies have suggested that postoperative hypopituitarism in patients with nonsellar intracranial tumors is caused by traumatic surgery. However, with development of minimally invasive and precise neurosurgical techniques, the degree of injury to brain tissue has been reduced significantly, especially for parenchymal tumors. Therefore, understanding preexisting hypopituitarism and related risk factors can improve perioperative management for patients with nonsellar intracranial tumors...
September 2017: World Neurosurgery
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