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Lupic Nephritis

Juliana Lins Loureiro, Katienne Goes Mendonça, Georgia de Araújo Pacheco, Maria Fernanda Lucena Soutinho, Gustavo Álvares Presídio, André Felipe dos Santos Ferreira, Agenor Antônio Barros da Silva, Fernando Melro Silva da Ressurreição, Ebeveraldo Amorim Gouveia, Carlos Alexandre Ferreira de Oliveira, Marcio Fernando Costa Medeiros, Rogério César Correia Bernardo
The spontaneous perirenal hemorrhage usually presents as sudden pain in the side ipsilateral, no history of trauma. Acquired cystic kidney disease is a common finding in chronic hemodialysis patients. However, spontaneous bleeding from the rupture of the cyst is a rare clinical entity. We describe the case of a female patient, 45 years old, with controlled hypertension for 8 years, chronic renal failure for 15 years and lupus nephritis 2 years ago, undergoing hemodialysis three times a week since 2006, and who presented concurrently acquired cystic kidney disease...
April 2013: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Crésio Alves, Teresa Cristina Vicente Robazzi, Manuela Fragomeni
OBJECTIVES: To report the unusual diagnosis of juvenile systemic lupus erythematosus (JSLE) in two adolescents with a previous diagnosis of Hashimoto's thyroiditis (HT). CASE REPORTS: Case # 1: An 11 year-old girl was diagnosed with HT. One year later, she presented with generalized edema, pericardial and pleural effusion, positive ANA, thrombocytopenia, increased anti-cardiolipin IgG and nephritis, being diagnosed with JSLE. (Case # 2): A 13 year-old girl was diagnosed with HT at the age of 10 years...
July 2010: Acta Reumatológica Portuguesa
Mathieu Sacquépée, Vincent Rouleau, Jean-François Cantin, Nicolas Quirin, Yves Doussy, Jean-Claude Valéry, Cristina Picu, Jean-Michel Tivollier
INTRODUCTION: Drug-induced lupus nephritis in patients treated with TNF α inhibitor is a rare adverse effect. Anti-TNF α therapies are commonly associated with the induction of auto-antibodies, whereas anti-TNF α-induced lupus is rare, most frequently involving arthritis and cutaneous lesions. However, several renal involvement has been reported. OBSERVATION: A 26-year old woman with a history of psoriasic arthritis treated with TNF α inhibitor (etanercept) presented with a biopsy-proved class IV lupus nephritis...
November 2010: Néphrologie & Thérapeutique
Aniel Jessica Leticia Brambila-Tapia, Ingrid Patricia Dávalos-Rodríguez
The G Immunoglobulin Fc Receptors (FcgammaR) belong to the TNFR5 receptors family, of the immunoglobulin superfamily and are widely expressed in the immune system; their function follows in importance after the complement receptors for immunocomplexes clearance. On the other hand, the systemic lupus erythematosus (SLE) is the prototype of the autoimmune diseases mediated by immunocomplexes and several studies have shown an impaired handle of these ones in part due to dysfunction of the FcgammaR. Among all types of Fcgamma receptors, the FcgammaRIIA, FcgammaRIIB, FcgammaRIIIA and FcgammaRIIIB have well characterized polymorphisms that produce an alteration in the receptor function...
January 2009: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
J Ballarín, M Díaz
We reviewed the literature in 2007 on 3 groups of systemic diseases affecting the kidney: lupic nephropathy (LN), small vessel vasculitis (SVV) and renal amyloidosis. A systematic review of 268 patients with LN pooled from 4 studies found that mycophenolic acid (MPA) in the induction phase caused more remissions and achieved greater renal survival than cyclophosphamide (CP), confirming it as a valid alternative to CP. Using a protocol including rituximab and MPA in the induction phase (14 days), MPA alone without corticoids is effective and safe in the maintenance phase...
2008: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
Manuela Ferreira, Ana Bárbara Salgueiro, João Estrada, José Ramos, Lurdes Ventura, M Carmo Vale, Deolinda Barata
Systemic Lúpus Erythematosus (SLE) is an auto-imune disorder, with multiple organ involvement, characterized by vascular and connective tissue inflammation, as well as antinuclear antibodies (ANA). We report a case of a black teenager with a past of arthritis of knees, fever and astenia during the year previous to this admission. She was admitted to the Pediatric Intensive Care Unit (PICU) for bilateral Streptococcus pneumoniae pneumonia complicated by pleural effusion. She also had generalized edema and macroscopic hematúria...
March 2008: Acta Médica Portuguesa
G Espinosa Garriga, R Cervera Segura
The therapeutic goals for a patient with newly diagnosed lupus nephritis should be to achieve a prompt renal remission, to avoid renal flares, to avoid chronic renal impairment, and to fulfil these objectives with minimal toxicity. An advance in the therapy of LN has been the introduction of concepts of induction of remission (by a sort course of vigorous immunosupression such as monthly intravenous cyclophosphamide) and maintenance of remission (by long-term administration of the same cytotoxic drug given less frequently or a potentially safer immunosupressant such as azathioprine)...
December 2007: Revista Clínica Española
M V Pereira, M P Revelo, E A Bambirra
The present study describes 21 cases (17 females and 01 male) of 12 year old patients, or younger, with diagnosis of SLE, that were submitted to renal biopsy. The histologic study demonstrated 10 cases of membranoproliferative glomerulonephritis (Class IV-WHO); 4 cases of focal proliferative glomerulonephritis (Class III-WHO; 2 cases of mesangial proliferative glomerulonephritis (Class II-WHO) and 2 cases of membranous glomerulonephritis (Class V-WHO). Three cases were excluded. In this study the incidence of lupus nephritis in children was small, similar to what has been described by other authors, and presenting unfavorable histologic patterns...
January 1996: Jornal de Pediatria
M J Vázquez García, M E Vargas Camaño, R Olalde Carmona
AIMS: Systemic Lupus Eritematosus is an autoimmune disease, the incidence in pediatric poblation in about 5%, and until 90% develop nephropathy. MATERIAL AND METHOD: Included patients with lupic nephropathy grade IV (OMS) ages between 0 and 16 years old, multitreated, who administrated PTX. We take samples before treatment, during, and 4 month after, evaluating renal function and hepatic function. RESULTS: For female, tow male, promedium age 14...
May 2000: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
M J Vázquez García, R Olalde Carmona, J A Juárez, D Escárcega Barbosa
BACKGROUND: Intravenous Immunoglobulin (i.v.Ig) has been advocated as efficacious for Systemic Lupus Erytematosus (SLE) and Lupic Nephritis (LN) using high dosages, propitious a prolonged remission of SLE. MATERIAL AND METHOD: We show the case of a male patient 16 years old, with SLE diagnosis until 1993, and LN phase IV. He attend to hospital with a Lupic Crisis, positives ANAs, DNAds, ScL 427, C3 45, C4 13, IgG 179, urinary sediment: leukocytes 30-40 xc, erythrocytes 8-10 xc...
November 1998: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
B Diouf, A O Toure, M M Ka, A Pouye, T M Diop
Systemic lupus erythematosus is a disease considered as seldom in Senegal. Nevertheless its incidence is increasing these last years. The prognosis is significantly related to the renal involvement, classified into 6 classes by the WHO. The treatment of these different forms is variable, consisting on abstention or symptomatic treatment for the class III (with low activity index), class II, I, and V (without renal failure). In the other hand a vigorous treatment is indicated in the class III, with consistent activity index, class IV and class V with renal failure...
1997: Dakar Médical
O Meyer, O Borda-Iriarte, T Haïm, A Ryckewaert
Low avidity native DNA - anti-native DNA complexes dissociate at alkaline pH and in high molarity solutions. This property was used to modify the indirect immunofluorescence reaction on Crithidia luciliae in order to assay high avidity anti-native DNA antibodies resistant to alkaline and strongly saline solutions. Assays were performed in the sera of 36 patients (31 women and 5 men) with systemic lupus erythematosus (SLE). Seventeen of these patients had histologically significant lupus nephritis (WHO types III, IV and V) and 19 had no renal, urinary or biochemical abnormalities...
December 22, 1984: La Presse Médicale
A Amerio, G Pastore, V Campese, F D'Agostino, M Rovito, M Micelli, G Pastore, E Sforza
Seventy cases of cholera were admitted to Hospital during 1973 cholera epidemic; 49 showed the symptoms of renal failure, 19 of whom with anuria. Acute renal failure is caused from hypertonic or isotonic dehydration, metabolic acidosis and potassium depletion. Clinically the pattern of a tubulo-interstitial nephritis can be found; a short oliguric or anuric phase followed by a poliuric phase lasting about 10 days. The glomerular function usually cames back to normal in 20 days time. As for the therapy, 16 of the above mentioned 19 anuric patients received a conservative treatment only; 3 patients with preexisting chronic nephropathy required peritoneal dialysis...
May 1975: Annali Sclavo; Rivista di Microbiologia e di Immunologia
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