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Maternal risk factor

Nick John Cave, Janis P Bridges, Karin Weidgraaf, David Granville Thomas
Obesity is highly prevalent in pet cats (Felis silvestris catus) and is associated with several comorbidities, yet very little is understood about the early life risk factors. The aim of this study was to develop a mathematical model that describes growth in cats, to determine which early life variables were associated with being overweight in adulthood and to identify when during life the overweight phenotype developed in a colony of cats. We used pedigree, birth and growth data of 212 colony cats that were fed ad libitum from weaning...
June 22, 2018: Journal of Animal Physiology and Animal Nutrition
Federica Tarquini, Elena Picchiassi, Giuliana Coata, Michela Centra, Vittorio Bini, Samanta Meniconi, Chiara Antonelli, Irene Giardina, Gian Carlo Di Renzo
The purpose of the present study was to search for associations between spontaneous preterm birth (sPTB), single nucleotide polymorphisms (SNPs) associated with the apoptotic pathway as triggered by oxidative stress, maternal lifestyle and health status. SNP genotyping [rs7560 for c-Jun N-terminal kinase (JNK), rs9517320 for mammalian STE20-like protein kinase 3 (MST3), rs1049216 for caspase 3 (CASP3)] in the placenta and maternal blood of 300 controls with at-term birth and 43 cases of sPTB was performed. No association was identified in genotype frequencies or combinations of foetal/maternal genotypes between single SNPs and sPTB...
July 2018: Biomedical Reports
D Gentilini, E Somigliana, L Pagliardini, E Rabellotti, P Garagnani, L Bernardinelli, E Papaleo, M Candiani, A M Di Blasio, P Viganò
Background: An increased incidence of imprint-associated disorders has been reported in babies born from assisted reproductive technology (ART). However, previous studies supporting an association between ART and an altered DNA methylation status of the conceived babies have been often conducted on a limited number of methylation sites and without correction for critical potential confounders. Moreover, all the previous studies focused on the identification of methylation changes shared among subjects while an evaluation of stochastic differences has never been conducted...
2018: Clinical Epigenetics
Y Sun, L Jin
OBJECTIVE: To explore the levels of blood manganese concentration in pregnant women in 1st and 2nd trimester and the associated factors in three counties of northern China. METHODS: We carried out a cross-sectional investigation in three counties of northern China in 2010. Two hundred and seventy three pregnant women whose gestational age was less than 28 weeks were recruited, their demographic characteristics and information on exposure to indoor air pollution from coal combustion and dietary during one month before pregnancy till the date of investigation were collected with questionnaires by face-to-face interview, their fasting venous whole blood samples were collected with vacuum blood collection tube containing heparin lithium at the Maternal and Child Health Hospital in the three counties...
June 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Houman Goudarzi, Satoshi Konno, Hirokazu Kimura, Atsuko Araki, Chihiro Miyashita, Sachiko Itoh, Yu Ait Bamai, Hiroki Kimura, Kaoruko Shimizu, Masaru Suzuki, Yoichi M Ito, Masaharu Nishimura, Reiko Kishi
BACKGROUND: Childhood allergies are dynamic and associated with environmental factors. The influence of prenatal maternal smoking and obesity on childhood allergies and their comorbidities remains unclear, especially in prospective cohorts with serial longitudinal observations. OBJECTIVE: We examined time trends in the prevalence and comorbidity of childhood allergies, including wheeze, eczema, and rhinoconjunctivitis, using a large-scale, population-based birth cohort in Japan, and assessed the effects of prenatal maternal smoking and BMI on the risk of childhood allergies...
October 15, 2018: Science of the Total Environment
Shanta Pandey
BACKGROUND AND PURPOSE: Home deliveries increase the risk of maternal and child mortality. To increase institutional deliveries, South Asian countries have introduced various forms of Conditional Cash Transfer (CCT) schemes that offer women cash if they come to deliver at a health facility. In 2005, Nepal introduced its Safe Delivery Incentive Programme (SDIP)-a cash incentive program nationwide to boost the rate of institutional delivery and care from health professionals at childbirth...
2018: PloS One
Liping Liu, Jianling Huang, Ying Wang, Yumei Li
BACKGROUND: Striae gravidarum is a common skin problem of considerable cosmetic concern for many pregnant women. Various risk factors associated with the development of striae have been reported, with conflicting results. OBJECTIVES: To analyze the risk factors of striae gravidarum in Chinese primiparous women and to provide evidence relevant to the prevention of this condition. METHODS: Singleton primiparous pregnant women who were hospitalized for delivery were included, and relevant data were collected...
2018: PloS One
Roslyn Carmel Giglia, Martyn Symons, Thérèse Shaw
BACKGROUND: In the 2009 National Health and Medical Research Council (NHMRC) Australian Guidelines to Reduce Health Risks from Drinking, a guideline specific to lactating women was included. For the first time the effect of alcohol at this important developmental stage was nationally and internationally acknowledged. AIMS: To determine the degree to which maternal health practitioners adopted an Australian national policy guideline (Guideline 4B) on alcohol and breastfeeding into their everyday health practice and the factors associated with adoption...
June 21, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
Joan M Rosell, L Fernando de la Fuente
In this cross-sectional study, prevalence of clinical mastitis (PCM) and farm-specific risk factors were determined on 531 doe rabbit farms in Spain and Portugal, from January 2001 through March 2017. The information was obtained by carrying out 2367 visits and doing physical examinations of 144,455 lactating does, sorted in 2635 cohorts. Overall mean PCM was 4.05% (CI95% [3.87⁻4.22]), (minimum to maximum: 0⁻36.00% PCM). This study suggests that PCM was influenced by the variable number of batches (a batch was a group of does served the same day), per maternity barn ( p < 0...
June 20, 2018: Animals: An Open Access Journal From MDPI
Raffael Ott, Jens H Stupin, Andrea Loui, Elisabeth Eilers, Kerstin Melchior, Rebecca C Rancourt, Karen Schellong, Thomas Ziska, Joachim W Dudenhausen, Wolfgang Henrich, Andreas Plagemann
BACKGROUND: Both gestational diabetes mellitus (GDM) as well as overweight/obesity during pregnancy are risk factors for detrimental anthropometric and hormonal neonatal outcomes, identified to 'program' adverse health predispositions later on. While overweight/obesity are major determinants of GDM, independent effects on critical birth outcomes remain unclear. Thus, the aim of the present study was to evaluate, in women with GDM, the relative/independent impact of overweight/obesity vs...
June 20, 2018: BMC Pregnancy and Childbirth
Kathleen Szegda, Elizabeth R Bertone-Johnson, Penelope Pekow, Sally Powers, Glenn Markenson, Nancy Dole, Lisa Chasan-Taber
BACKGROUND: Latina women are at increased risk for antenatal depressive disorders, which are common during pregnancy and are associated with elevated risk for poor maternal health and birth outcomes. Physical activity is a potential mechanism to reduce the likelihood of depressive symptoms. The purpose of the study was to assess whether total and domain-specific physical activity in early pregnancy reduced risk for elevated antenatal depressive symptoms in mid-late pregnancy in a population of Latina women at high-risk for depression...
June 20, 2018: BMC Pregnancy and Childbirth
Marco Solmi, Cristiano A Köhler, Brendon Stubbs, Ai Koyanagi, Beatrice Bortolato, Francesco Monaco, Davy Vancampfort, Myrela O Machado, Michael Maes, Ioanna Tzoulaki, Joseph Firth, John P A Ioannidis, André F Carvalho
BACKGROUND: Multiple environmental factors have been implicated in obesity and multiple interventions, besides drugs and surgery, have been assessed in obese patients. Results are scattered across many studies and meta-analyses and they often mix obese and overweight individuals. MATERIALS AND METHODS: PubMed and Cochrane Database of Systematic Reviews were searched through January 21st , 2017 for meta-analyses of cohort studies assessing environmental risk factors for obesity, and randomized controlled trials investigating non-pharmacological, non-surgical therapeutic interventions for obesity...
June 20, 2018: European Journal of Clinical Investigation
Hua He, Anne Monique Nuyt, Zhong-Cheng Luo, Francois Audibert, Lise Dubois, Shu-Qin Wei, Haim A Abenhaim, Emmanuel Bujold, Isabelle Marc, Pierre Julien, William D Fraser
Small for gestational age (SGA) infants are at increased risk of type 2 diabetes in adulthood. It is unknown whether any prenatal biomarkers are helpful for identifying SGA infants with altered metabolic health profile at birth or later life. In a nested study of 162 SGA (birth weight < 10th percentile) and 161 optimal birth weight (25th-75th percentiles) control infants in the 3D (design, develop and discover) birth cohort in Canada, we assessed whether maternal circulating placental growth factor (PlGF), a biomarker of placental function, is associated with metabolic health biomarkers in SGA infants...
2018: Frontiers in Endocrinology
Heather R Masters, Emily Housley, James W Van Hook, Emily DeFranco
OBJECTIVE:  We aim to quantify the impact of obesity on maternal intensive care unit (ICU) admission. MATERIALS AND METHODS:  This is a population-based, retrospective cohort study of Ohio live births from 2006 to 2012. The primary outcome was maternal ICU admission. The primary exposure was maternal body mass index (BMI). Relative risk (RR) of ICU admission was calculated by BMI category. Multivariate logistic regression quantified the risk of obesity on ICU admission after adjustment for coexisting factors...
June 19, 2018: American Journal of Perinatology
Hanna C Gustafsson, Elinor L Sullivan, Elizabeth K Nousen, Ceri A Sullivan, Elaine Huang, Monica Rincon, Joel T Nigg, Jennifer M Loftis
Maternal depressive symptoms during pregnancy are associated with risk for offspring emotional and behavioral problems, but the mechanisms by which this association occurs are not known. Infant elevated negative affect (increased crying, irritability, fearfulness, etc.) is a key risk factor for future psychopathology, so understanding its determinants has prevention and early intervention potential. An understudied yet promising hypothesis is that maternal mood affects infant mood via maternal prenatal inflammatory mechanisms, but this has not been prospectively examined in humans...
June 16, 2018: Brain, Behavior, and Immunity
Ariani Impieri Souza, Marília Teixeira de Siqueira, Ana Laura Carneiro Gomes Ferreira, Clarice Umbelino de Freitas, Anselmo César Vasconcelos Bezerra, Adeylson Guimarães Ribeiro, Adelaide Cássia Nardocci
OBJECTIVES: We assessed sociodemographic and health care factors of mothers and newborns during a 2015-2016 outbreak of microcephaly in Recife, Brazil, and we analyzed the spatial distribution and incidence risk of newborns with microcephaly in relation to socio-environmental indicators. METHODS: We collected data from August 2015 through May 2016 from Brazil's Live Birth Information System and Bulletin of Microcephaly Notification, and we geocoded the data by maternal residence...
January 1, 2018: Public Health Reports
Cynthia Chen, Neil Kaushal, David M Scher, Shevaun M Doyle, John S Blanco, Emily R Dodwell
BACKGROUND: Clubfoot is a common congenital anomaly with multiple potential risk factors. Identification of modifiable risk factors may minimize future incidence of clubfoot. The aim of this meta-analysis was to systematically review and analyze the best clinical evidence regarding risk factors associated with clubfoot. METHODS: Medline, Embase, and Cochrane databases were systematically searched from 1967 to May 11, 2016 for studies reporting risk factors for clubfoot...
June 18, 2018: Journal of Pediatric Orthopedics
Amrita Sarkar, Ophelia Mary Kharmujai, Wallambok Lynrah, Neilatuo U Suokhrie
Background: In Meghalaya, only 51.4% expectant mothers go for any institutional delivery with a wide rural-urban gap causing morbidity and mortality in the mothers and the neonates. Objectives: The objective of this study is to find out the factors influencing the choice of the place of delivery in rural women. Methodology: The present qualitative cross-sectional study was conducted from October to December 2016 in Bhoirymbong community health center (CHC) and the area catered to by it...
January 2018: Journal of Family Medicine and Primary Care
Nora Shero, Sylvain Fiset, Hélène Plamondon, Mohamed Thabet, France M Rioux
Iron deficiency (ID) has been reported as a risk factor in the pathology of attention-deficit/hyperactivity disorder, although the mechanisms seem unclear. Previous results from our research group showed that guinea pig offspring born from ID dams were significantly more active in the Open Field Test than the controls. This behavior could potentially be associated to stress. We therefore hypothesized that maternal iron deficiency (MID) elevates the offspring serum cortisol, a biomarker of stress, during childhood and possibly at mature age...
June 2018: Nutrition Research
C Horwood, L Haskins, I M Engebretsen, S Phakathi, C Connolly, A Coutsoudis, L Spies
BACKGROUND: Increasing the rate of exclusive breastfeeding (EBF) to 50% in the first six months of life is one of six major global targets set by the United Nations Decade of Nutrition, and is essential to achieve the sustainable development goals to eradicate hunger and end malnutrition by 2030. METHODS: A survey using multistage random sampling design included 99 primary health care (PHC) clinics in all 11 districts in KwaZulu-Natal (KZN). All mothers and caregivers of infants 14 weeks of age attending the clinics in the study period were requested to participate in a structured interview to explore feeding practices since birth...
June 19, 2018: BMC Public Health
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