keyword
MENU ▼
Read by QxMD icon Read
search

testosterone brain

keyword
https://www.readbyqxmd.com/read/28813252/oxytocin-a-parenting-hormone
#1
REVIEW
Ruth Feldman, Marian J Bakermans-Kranenburg
In non-human mammals mothering is hormone-dependent, with crucial roles for oxytocin and prolactin. While human parenting is not hormone-dependent, hormonal changes in oxytocin, vasopressin, prolactin, testosterone, and cortisol prime and accompany the expression of parenting. In the following we focus on oxytocin (OT) as a key hormone in human parenting. OT is a nine-amino-acid neuropeptide hormone which evolved from the ancient vasotocin molecule approximately 650 MYO. OT is implicated in sociality across vertebrate evolution and substantial research has pinpointed its role in birth, lactation, and maternal care in mammals...
June 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28801581/bpifcl-modulates-kiss2-expression-under-the-influence-of-11-ketotestosterone-in-female-zebrafish
#2
Shogo Moriya, Nabila Tahsin, Ishwar S Parhar
The bactericidal/permeability-increasing (BPI) fold-containing (BPIF) superfamily of genes expressed in the brain are purportedly involved in modulating brain function in response to stress, such as inflammation. Kisspeptin, encoded by kiss, is affected by inflammation in the brain; therefore, BPIF family genes might be involved in the modulation of kisspeptin in the brain. In this study, we investigated the expression of BPIF family C, like (bpifcl) in zebrafish brain and its involvement in kiss2 regulation...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28797804/a-game-of-two-gene-expression-analysis-of-brain-cyp19a1b-and-gonadal-cyp19a1a-aromatase-in-females-of-a-neotropical-cichlid-fish-through-the-parental-care-period-and-removal-of-the-offspring
#3
Martín R Ramallo, Renato M Honji, Agustina Birba, Leonel Morandini, María L Varela, Griselda Genovese, Renata G Moreira, Gustavo M Somoza, Matías Pandolfi
For many species parental behavior is essential for the survival of the offspring. While the ultimate causes of teleost parental behavior have been widely studied, comparatively little is known about its proximate causes. The aim of this study was to analyze the yet unexplored, potential dual role of brain and gonadal aromatases, the enzymes responsible for the conversion of androgens to estrogens in the brains and gonads of teleosts, respectively, on the different stages of the maternal care period of the biparental cichlid Cichlasoma dimerus, locally known as chanchita...
August 7, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28782547/early-life-stress-increases-testosterone-and-corticosterone-and-alters-stress-physiology-in-zebra-finches
#4
J Bayley Zito, Angy Hanna, Nora Kadoo, Michelle L Tomaszycki
Early life stress has enduring effects on behavior and physiology. However, the effects on hormones and stress physiology remain poorly understood. In the present study, parents of zebra finches of both sexes were exposed to an increased foraging paradigm from 3 to 33days post hatching. Plasma and brains were collected from chicks at 3 developmental time points: post hatching days 25, 60 and adulthood. Plasma was assayed for testosterone (T), estradiol (E2), and corticosterone (CORT). The paraventricular nucleus of the hypothalamus was assessed for corticotrophin releasing factor (CRH) and glucocorticoid receptor (GR) expression...
August 3, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28780570/sex-steroids-differentially-regulate-fshb-lhb-and-gnrhr-expression-in-atlantic-cod-gadus-morhua
#5
Kristine von Krogh, Gunnveig Toft Bjørndal, Rasoul Nourizadeh-Lillabadi, Kjetil Hodne, Erik Ropstad, Trude Marie Haug, Finn-Arne Weltzien
Depending on the stage of gonad maturation, as well as other factors, gonadal steroids can exert either a positive or negative feedback at the brain and pituitary level. While this has been demonstrated in many teleost species, little is known about the nature of steroid feedback in Gadiform fish. Using an optimized in vitro model system of the Atlantic cod pituitary, the present study investigated potential effects of two physiologically relevant doses of estradiol, testosterone or dihydrotestosterone (DHT) on cell viability and gene expression of gonadotropin subunits (fshb/lhb) and two suggested reproduction relevant gonadotropin-releasing hormone receptors (gnrhr1b/gnrhr2a) during three stages of sexual maturity...
August 5, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28779857/hormonal-changes-over-the-spawning-cycle-in-the-female-three-spined-stickleback-gasterosteus-aculeatus
#6
Chrysoula Roufidou, Monika Schmitz, Ian Mayer, Marion Sebire, Ioanna Katsiadaki, Yi Ta Shao, Bertil Borg
Female three-spined sticklebacks are batch spawners laying eggs in a nest built by the male. We sampled female sticklebacks at different time points, when they were ready to spawn and 6, 24, 48 and 72 hours post-spawning (hps) with a male. Following spawning, almost all females (15 out of 19) had ovulated eggs again at Day 3 post-spawning (72hps). At sampling, plasma, brain and pituitaries were collected, and the ovary and liver were weighed. Testosterone (T) and estradiol (E2) were measured by radioimmunoassay...
August 2, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28777257/chronic-levetiracetam-decreases-hippocampal-and-testicular-aromatase-expression-in-normal-but-not-kainic-acid-induced-experimental-model-of-acute-seizures-in-rats
#7
Mehtap Cincioğlu-Palabiyik, Meral Üner, Dilek Ertoy-Baydar, Yildirim Sara, Hande Karahan, Pelin Kelicen-Uğur
Reproductive disorders are more common in men with epilepsy taking anticonvulsant medications. Antiseizure/anticonvulsant drugs and seizures in medial temporal lobe structures may cause gonadal dysfunction, including infertility, decreased libido, and potency. Levels of circulating bioavailable testosterone are affected by the aromatase enzyme, which converts testosterone into estrogen and may be affected by seizure medications. However, the relationship of anticonvulsant drugs with central aromatase levels is not clear...
August 2, 2017: Neuroreport
https://www.readbyqxmd.com/read/28776866/prenatal-androgen-receptor-activation-determines-adult-alcohol-and-water-drinking-in-a-sex-specific-way
#8
Sabine E Huber, Iulia Zoicas, Martin Reichel, Christiane Mühle, Christian Büttner, Arif B Ekici, Volker Eulenburg, Bernd Lenz, Johannes Kornhuber, Christian P Müller
Alcohol use disorders are major psychiatric disorders. Correlational studies in humans suggested organizational hormonal effects during embryonic development as a risk factor for adult alcohol dependence. Permanent changes can be induced by the activity of sex hormones, like testosterone. Here, we demonstrate a relationship between prenatal androgen receptor (AR)-activation and adult alcohol as well as water drinking in mice in a sex-dependent fashion. Prenatal AR inhibition using the antagonist flutamide decreased adult male alcohol consumption...
August 4, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28757249/seasonal-and-sex-differences-in-cell-proliferation-neurogenesis-and-cell-death-within-the-dentate-gyrus-of-adult-wild-caught-meadow-voles
#9
Mark D Spritzer, Alyssa Panning, Shannon M Engelman, W Tyler Prince, Alexander E Casler, Joanna E Georgakas, Eliza C B Jaeger, Laura R Nelson, Ethan A Roy, Benjamin A Wagner
Past research indicates that female meadow voles (Microtus pennsylvanicus) show decreased neurogenesis within the hippocampus during the breeding season relative to the non-breeding season, whereas male voles show no such seasonal changes. We expanded upon these results by quantifying a variety of endogenous cell proliferation and neurogenesis markers in wild-caught voles. Adult male and female voles were captured in the summer (breeding season) or fall (non-breeding season), and blood samples and brain tissue were collected...
July 28, 2017: Neuroscience
https://www.readbyqxmd.com/read/28734725/estrogen-receptor-alpha-is-required-in-gabaergic-but-not-glutamatergic-neurons-to-masculinize-behavior
#10
Melody V Wu, Jessica Tollkuhn
Masculinization of the altricial rodent brain is driven by estrogen signaling during a perinatal critical period. Genetic deletion of estrogen receptor alpha (Esr1/ERα) results in altered hypothalamic-pituitary-gonadal (HPG) axis signaling and a dramatic reduction of male sexual and territorial behaviors. However, the role of ERα in masculinizing distinct classes of neurons remains unexplored. We deleted ERα in excitatory or inhibitory neurons using either a Vglut2 or Vgat driver and assessed male behaviors...
July 20, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28693284/%C3%AE-human-chorionic-gonadotropin-secreting-intracranial-germ-cell-tumor-associated-with-high-testosterone-in-an-adult-man-a-case-report
#11
Wen-Ping Yang, Hung-Yu Chien, Yi-Chun Lin
A 38-year-old male patient presented with general weakness, polydipsia and a body weight loss of 10 kg in two years. Hypopituitarism with central hypothyroidism and central adrenal insufficiency were noted at Taipei City Hospital (Taipei, Taiwan). However, hypogonadotropic hypergonadism was also observed. The patient was diagnosed with an intracranial β-human chorionic gonadotropin (β-hCG) secreting germ-cell tumor, and brain magnetic resonance imaging revealed that the tumor involved the pineal gland, stalk, posterior pituitary gland, right basal ganglion, hypothalamus, corpus callosum and posterior hippocampus...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28692878/sex-specific-association-of-sex-hormones-and-gonadotropins-with-brain-amyloid-and-hippocampal-neurodegeneration
#12
Jun Ho Lee, Min Soo Byun, Dahyun Yi, Young Min Choe, Hyo Jung Choi, Hyewon Baek, Bo Kyung Sohn, Jun-Young Lee, Hyun Jung Kim, Jee Wook Kim, Younghwa Lee, Yu Kyeong Kim, Chul-Ho Sohn, Jong Inn Woo, Dong Young Lee
This study aimed to examine the sex-specific association between serum sex hormones and gonadotropins and the cerebral beta-amyloid (Aβ) burden and hippocampal neurodegeneration in subjects with normal cognition and impaired cognition. Two hundred sixty-five older subjects received clinical assessments, serum measurements of sex hormones, gonadotropins, (11)C-Pittsburgh compound B-positron emission tomography, and magnetic resonance imaging. In females, higher free testosterone and gonadotropin levels were associated with lower cerebral Aβ positivity...
June 19, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28690571/the-correlation-among-neural-dynamic-processing-of-conflict-control-testosterone-and-cortisol-levels-in-10-year-old-children
#13
Fangfang Shangguan, Tongran Liu, Xiuying Liu, Jiannong Shi
Cognitive control is related to goal-directed self-regulation abilities, which is fundamental for human development. Conflict control includes the neural processes of conflict monitoring and conflict resolution. Testosterone and cortisol are essential hormones for the development of cognitive functions. However, there are no studies that have investigated the correlation of these two hormones with conflict control in preadolescents. In this study, we aimed to explore whether testosterone, cortisol, and testosterone/cortisol ratio worked differently for preadolescent's conflict control processes in varied conflict control tasks...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28679622/extra-ovarian-gonadotropin-negative-feedback-revealed-by-aromatase-inhibition-in-female-marmoset-monkeys
#14
Marissa Kraynak, Matthew T Flowers, Robert A Shapiro, Amita Kapoor, Jon Levine, David H Abbott
While the ovary produces the majority of estradiol (E2) in mature female primates, extra-ovarian sources contribute to E2 synthesis and action, including brain E2 regulating hypothalamic gonadotropin-releasing hormone (GnRH). In ovary-intact female rodent models, aromatase inhibition (AI) induces a PCOS-like hypergonadotropic hyperandrogenism due to absent E2-mediated negative feedback. In order to examine the role of extra-ovarian E2 on nonhuman primate gonadotropin regulation, the present study employs letrozole to elicit AI in adult female marmoset monkeys...
July 5, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28676251/the-not-so-bitter-pill-effects-of-combined-oral-contraceptives-on-peripheral-physiological-indicators-of-emotional-reactivity
#15
Diana Armbruster, Clemens Kirschbaum, Alexander Strobel
Combined oral contraceptives (COC) are used by millions of women worldwide. Although findings are not entirely consistent, COC have been found to impact on brain function and, thus, to modulate affective processes. Here, we investigated electro-physiological responses to emotional stimuli in free cycling women in both the early follicular and late luteal phase as well as in COC users. Skin conductance response (SCR), startle reflex, corrugator and zygomaticus activity were assessed. COC users showed reduced overall startle magnitude and SCR amplitude, but heightened overall zygomaticus activity, although effect sizes were small...
July 19, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28661908/associations-between-hormonal-biomarkers-and-cognitive-motor-and-language-developmental-status-in-very-low-birth-weight-infants
#16
June Cho, Diane Holditch-Davis, Xiaogang Su, Vivien Phillips, Fred Biasini, Waldemar A Carlo
BACKGROUND: Male infants are more prone to health problems and developmental delays than female infants. OBJECTIVES: On the basis of theories of gender differences in brain development and social relationships, we explored associations between testosterone and cortisol levels with infant cognitive, motor, and language development ("infant development") in very low birth weight (VLBW) infants, controlling for mother-infant interactions, characteristics of mothers and infants, and days of saliva collection after birth...
June 28, 2017: Nursing Research
https://www.readbyqxmd.com/read/28655134/multiple-mechanisms-linking-type-2-diabetes-and-alzheimer-s-disease-testosterone-as-a-modifier
#17
Prita R Asih, Michelle L Tegg, Hamid Sohrabi, Malcolm Carruthers, Samuel E Gandy, Farid Saad, Giuseppe Verdile, Lars M Ittner, Ralph N Martins
Evidence in support of links between type-2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) has increased considerably in recent years. AD pathological hallmarks include the accumulation of extracellular amyloid-β (Aβ) and intracellular hyperphosphorylated tau in the brain, which are hypothesized to promote inflammation, oxidative stress, and neuronal loss. T2DM exhibits many AD pathological features, including reduced brain insulin uptake, lipid dysregulation, inflammation, oxidative stress, and depression; T2DM has also been shown to increase AD risk, and with increasing age, the prevalence of both conditions increases...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28654759/taurine-reverses-sodium-fluoride-mediated-increase-in-inflammation-caspase-3-activity-and-oxidative-damage-along-the-brain-pituitary-gonadal-axis-in-male-rats
#18
Isaac A Adedara, Bolanle F Olabiyi, TeminiJesu D Ojuade, Umar F Idris, Esther M Onibiyo, Ebenezer O Farombi
Excessive exposure to fluoride is associated with male reproductive dysfunction in humans and animals. Taurine (2-aminoethane sulfonic acid) is a free intracellular β-amino acid with antioxidant, anti-inflammatory, and neuroprotective properties. However, the effect of taurine on fluoride-induced reproductive toxicity has not been reported. The present study investigated the influence of taurine on sodium fluoride (NaF)-induced functional changes along the brain-pituitary-gonadal axis in male rats. NaF was administered singly in drinking water at 15 mg·L(-1) alone or orally co-administered by gavage with taurine at 100 and 200 mg·(kg body mass)(-1) for 45 consecutive days...
June 27, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28609670/differential-effects-of-the-18-kda-translocator-protein-tspo-ligand-etifoxine-on-steroidogenesis-in-rat-brain-plasma-and-steroidogenic-glands-pharmacodynamic-studies
#19
Philippe Liere, Antoine Pianos, Jean-Paul Oudinet, Michael Schumacher, Yvette Akwa
Etifoxine is indicated in humans for treating anxiety. In rodents, besides its anxiolytic-like properties, it has recently shown neuroprotective and neuroregenerative activities. It acts by enhancing GABAA receptor function and by stimulating acute steroid biosynthesis via the activation of the 18-kDa translocator protein. However, the regulatory action of etifoxine on steroid production is not well characterized. In this work, we performed dose-response, acute and chronic time-course experiments on the effects of intraperitoneal injections of etifoxine on steroid levels in adult male rat brain and plasma analyzed by gas chromatography-mass spectrometry...
June 3, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28609669/sex-differences-in-associations-between-white-matter-microstructure-and-gonadal-hormones-in-children-and-adolescents-with-prenatal-alcohol-exposure
#20
K A Uban, M M Herting, J R Wozniak, E R Sowell
Despite accumulating evidence from animal models demonstrating that prenatal alcohol exposure (PAE) results in life-long neuroendocrine dysregulation, very little is known on this topic among humans with fetal alcohol spectrum disorders (FASD). We expected that alterations in gonadal hormones might interfere with the typical development of white matter (WM) myelination, and in a sex-dependent manner, in human adolescents with FASD. In order to investigate this hypothesis, we used diffusion tensor imaging (DTI) to assess: 1) whether or not sex moderates the impact of PAE on WM microstructure; and 2) how gonadal hormones relate to alterations in WM microstructure in children and adolescents affected by PAE...
May 26, 2017: Psychoneuroendocrinology
keyword
keyword
115094
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"