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Serum Cobalamin

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https://www.readbyqxmd.com/read/29772976/effects-of-storage-conditions-and-duration-on-cobalamin-concentration-in-serum-samples-from-cats-and-dogs
#1
Jennifer Kempf, Roger H Melliger, Claudia E Reusch, Peter H Kook
OBJECTIVE To evaluate the effects of storage conditions and duration on cobalamin concentration in serum samples from dogs and cats. DESIGN Experiment. SAMPLE Serum samples from 9 client-owned cats and 9 client-owned dogs. PROCEDURES Serum harvested from freshly obtained blood samples was separated into 11 aliquots/animal. One aliquot (baseline sample) was routinely transported in light-protected tubes to the laboratory for cobalamin assay; each of the remaining aliquots was stored in a refrigerator (6°C; n = 5) or at room temperature (20°C) with exposure to daylight (5) for 24, 48, 72, 96, or 120 hours...
June 1, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29741927/transcellular-transport-of-cobalamin-in-aortic-endothelial-cells
#2
Luciana Hannibal, Keerthana Bolisetty, Armend Axhemi, Patricia M DiBello, Edward V Quadros, Sergey Fedosov, Donald W Jacobsen
Cobalamin [Cbl (or B12 )] deficiency causes megaloblastic anemia and a variety of neuropathies. However, homeostatic mechanisms of cyanocobalamin (CNCbl) and other Cbls by vascular endothelial cells are poorly understood. Herein, we describe our investigation into whether cultured bovine aortic endothelial cells (BAECs) perform transcytosis of B12 , namely, the complex formed between serum transcobalamin and B12 , designated as holo-transcobalamin (holo-TC). We show that cultured BAECs endocytose [57 Co]-CNCbl-TC (source material) via the CD320 receptor...
May 9, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29721769/characterization-of-the-complex-between-native-and-reduced-bovine-serum-albumin-with-aquacobalamin-and-evidence-of-dual-tetrapyrrole-binding
#3
Ilia A Dereven'kov, Luciana Hannibal, Sergei V Makarov, Anna S Makarova, Pavel A Molodtsov, Oskar I Koifman
Serum albumin binds to a variety of endogenous ligands and drugs. Human serum albumin (HSA) binds to heme via hydrophobic interactions and axial coordination of the iron center by protein residue Tyr161. Human serum albumin binds to another tetrapyrrole, cobalamin (Cbl), but the structural and functional properties of this complex are poorly understood. Herein, we investigate the reaction between aquacobalamin (H2 OCbl) and bovine serum albumin (BSA, the bovine counterpart of HSA) using Ultraviolet-Visible and fluorescent spectroscopy, and electron paramagnetic resonance...
May 2, 2018: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/29667183/effect-of-enterococcus-faecium-sf68-on-serum-cobalamin-and-folate-concentrations-in-healthy-dogs
#4
R Lucena, A B Olmedilla, B Blanco, M Novales, P J Ginel
OBJECTIVE: To study the effect of a 14-day administration of the probiotic Enterococcus faecium SF68 on serum concentrations of cobalamin and folate in healthy dogs. MATERIALS AND METHODS: Thirty-six healthy dogs were randomly allocated between probiotic and control groups. Enterococcus faecium SF68 was administered to the probiotic group for 14 days whereas the control group did not receive any product. A blood sample was taken from all dogs when starting the administration (day 1), when the administration ended (day 14) and 14 days later (day 28)...
April 17, 2018: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29651724/serum-folate-and-cobalamin-levels-and-urinary-dimethylarsinic-acid-in-us-children-and-adults
#5
Jianmin Zhu, Yanhui Gao, Dianjun Sun, Yudan Wei
Nutritional status could affect arsenic metabolism and toxicity in the general population chronically exposed to low levels of inorganic arsenic. In this study, we examined the association of serum folate and cobalamin with urinary concentrations of dimethylarsinic acid (DMA), the most abundant metabolite of inorganic arsenic measured in urine, in children and adults who participated in the 2003-2006 US National Health and Nutrition Examination Surveys. A total of 1161 children (aged 6-19 years) and 1938 adults (aged 20-85 years) were analyzed for the association using multivariate general linear models, adjusting for potential confounders...
April 12, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29577819/comparison-of-the-efficacy-of-parenteral-and-oral-treatment-for-nutritional-vitamin-b12-deficiency-in-children
#6
Rabia Gönül Sezer, Handan Ayhan Akoğlu, Abdulkadir Bozaykut, Gül Nihal Özdemir
OBJECTIVE: Although, oral replacement for vitamin B12 deficiency has been proved to be effective in adults, it is mainly treated with parenteral therapy. There are only few studies on oral replacement therapy of vitamin B12 with children. Therefore, we aimed to compare the efficacy of oral treatment with intramuscular vitamin B12 injections in pediatric population. METHODS: Children with serum cobalamin concentrations less than 300 pg/mL, were treated either with the parenteral therapy or with oral vitamin B12...
March 24, 2018: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29572946/prospective-long-term-evaluation-of-parenteral-hydroxocobalamin-supplementation-in-juvenile-beagles-with-selective-intestinal-cobalamin-malabsorption-imerslund-gr%C3%A3-sbeck-syndrome
#7
Peter Hendrik Kook, C E Reusch, M Hersberger
BACKGROUND: Prospective studies on maintenance treatment for Beagles with hereditary selective cobalamin (Cbl) malabsorption (Imerslund-Gräsbeck syndrome, IGS) are lacking. In our experience, measurement of methylmalonic acid (MMA), a Cbl-dependent metabolite, seems more helpful to monitor Cbl status as compared with serum Cbl concentrations. OBJECTIVES: To evaluate a standardized Cbl supplementation scheme in Beagles with IGS. We hypothesized that a single parenteral dose of 1 mg hydroxocobalamin (OH-Cbl) would maintain clinical and metabolic remission for up to 2 months...
March 23, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29536459/correlation-of-clinical-diagnostic-and-histopathological-parameters-in-dogs-with-chronic-lymphocytic-plasmacytic-enteropathy
#8
Katharina Moser, Stefanie Mitze, Erik Teske, Wolf von Bomhard, Christian Stockhaus
OBJECTIVE: The objective of this study was to correlate clinical signs and diagnostic parameters with duodenal inflammatory and architectural changes in dogs with lymphocytic-plasmacytic enteropathy. MATERIAL AND METHODS: In a retrospective study dogs presented between 2003 and 2014 with chronic gastrointestinal signs (duration > 3 weeks) and histologic evidence of intestinal lymphocytic-plasmacytic inflammation were evaluated. Clinical signs, serum albumin, cobalamin and folic acid concentrations were recorded and a sonographic, endoscopic, histologic and cytological inflammatory score was determined...
February 2018: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/29529156/early-pregnancy-folate-cobalamin-interactions-and-their-effects-on-cobalamin-status-and-hematologic-variables-throughout-pregnancy
#9
Pol Solé-Navais, Judith Salat-Batlle, Pere Cavallé-Busquets, Joan Fernandez-Ballart, Per M Ueland, Mónica Ballesteros, Gemma Ornosa-Martín, Montserrat Inglès-Puig, Jose M Colomina, Michelle M Murphy
Background: Periconception folic acid supplementation is widespread, but how it interacts with cobalamin status is rarely considered. Objective: The aim of this study was to investigate whether first-trimester folate-cobalamin interactions affect pregnancy cobalamin status, hematologic variables, and pregnancy outcomes. Design: In the longitudinal Reus-Tarragona Birth Cohort study from <12 gestational weeks throughout pregnancy, fasting plasma and red blood cell (RBC) folate, plasma cobalamin, holotranscobalamin (holoTC), methylmalonic acid (MMA), total homocysteine (tHcy), hemoglobin, mean cell volume (MCV), postglucose-load serum glucose, gestational hypertension, gestational age at birth, and birth weight were recorded in 563 participants...
February 1, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29499976/effect-of-two-different-sublingual-dosages-of-vitamin-b-12-on-cobalamin-nutritional-status-in-vegans-and-vegetarians-with-a-marginal-deficiency-a-randomized-controlled-trial
#10
Cristian Del Bo', Patrizia Riso, Claudio Gardana, Antonella Brusamolino, Alberto Battezzati, Salvatore Ciappellano
BACKGROUND & AIMS: Vegetarians and vegans are more vulnerable to vitamin B12 deficiency with severe risks of megaloblastic anemia, cognitive decline, neuropathy, and depression. An easy and simple method of supplementation consists of taking one weekly dosage of 2000 μg. However, single large oral doses of vitamin B12 are poorly absorbed. The present research evaluates the ability of two different sublingual dosages of vitamin B12 (350 μg/week vs 2000 μg/week) in improving cyanocobalamin (vitamin B12 ) nutritional status in vegans and vegetarians with a marginal deficiency...
February 15, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29465562/subacute-onset-leukodystrophy-and-visual-spatial-disorders-revealing-phenylketonuria-combined-with-homocysteinmia-in-adulthood-a-case-report
#11
Chunchen Wang, Jieying Li
RATIONALE: Phenylketonuria (PKU) is a metabolic disorder, which manifests a progressive irreversible neurological impairment during infancy and childhood. Hyperhomocysteinemia also showed that it might be involved in pathophysiology of many neuropsychiatric disorders. The late-onset clinical manifestations of these 2 diseases have not been reported elsewhere. We speculated that the late-onset PKU is caused by 2 kinds of metabolic dysfunction synergistically, especially a short period of irregular diet directly caused clinical symptoms...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29428088/comparison-of-efficacy-of-oral-and-parenteral-cobalamin-supplementation-in-normalising-low-cobalamin-concentrations-in-dogs-a-randomised-controlled-study
#12
L Toresson, J M Steiner, P Razdan, E Spodsberg, G Olmedal, J S Suchodolski, T Spillmann
The aim of this study was to compare the efficacies of parenteral and oral cobalamin supplementation protocols in dogs with chronic enteropathies and low cobalamin concentrations. It was hypothesised that both treatments would increase serum cobalamin concentrations significantly. Fifty-three dogs with chronic enteropathies and serum cobalamin concentrations<285ng/L (reference interval 244-959ng/L) were enrolled. Dogs were randomised to treatment with either daily oral cobalamin tablets (0.25-1.0mg cyanocobalamin daily according to body weight) or parenteral cobalamin (0...
February 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29384828/evaluation-of-vitamin-b12-deficiency-and-associated-factors-in-patients-with-systemic-sclerosis
#13
Diler Tas Kilic, Ali Akdogan, Levent Kilic, Alper Sari, Abdulsamet Erden, Berkan Armagan, Muhammed Kilickaya, Umut Kalyoncu, Turan Turhan, Sedat Kiraz, Selma Karaahmetoglu
BACKGROUND/OBJECTIVE: In patients with systemic sclerosis (SSc) gastrointestinal (GI) involvement, nutritional status and medications may lead to cobalamin (Vit B12) deficiency. We aimed to determine the frequency and the potential causes of Vit B12 deficiency in SSc patients. METHODS: We conducted a cross-sectional analysis of 62 SSc patients in a single center in 1 year period. Medical history and physical examination of patients were reevaluated. Data about organ involvements were obtained from hospital file records...
January 30, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29374341/late-onset-cobalamin-c-deficiency-chinese-sibling-patients-with-neuropsychiatric-presentations
#14
Sheng-Jun Wang, Chuan-Zhu Yan, Yi-Ming Liu, Yu-Ying Zhao
The Cobalamin C deficiency (cblC), characterized with elevated methylmalonic acidemia and homocystinuria in plasma, is an inborn error of cobalamin metabolism. The late-onset cblC siblings patients were rarely reported. In this study, we analyzed the clinical presentations and treatment outcomes of late-onset cblC in Chinese sibling patients with neuropsychiatric presentations. The clinical data of four pairs of Chinese patients were retrospectively analyzed. Serum homocysteine, urine organic acids measurements, neuroimaging exams and gene analysis were carried out in all patents...
January 26, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29313750/serum-retinol-folic-acid-and-copper-are-associated-with-sperm-abnormalities-in-men-with-obesity
#15
Berniza Calderón, Vital Hevia, Belén Vega-Piñero, Antonia Martín-Hidalgo, Helena Mendez-Del Sol, Héctor F Escobar-Morreale, José I Botella-Carretero
BACKGROUND AND OBJECTIVES: Micronutrients may influence the development and differentiation of sperm cells. The aim of this study was to assess the possible association of deficiencies in several vitamins and trace elements with sperm abnormalities in men with obesity. PARTICIPANTS AND METHODS: Thirty male patients with moderate to severe obesity and ten lean controls who gave written informed consent were included. Anthropometric parameters were recorded. Hormonal and lipid profiles were analyzed, as well as serum concentrations of zinc, copper, retinol, α-tocopherol, 25-hydroxyvitamin D, cobalamin, and folic acid...
March 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29306994/association-between-maternal-and-infantile-markers-of-cobalamin-status-during-the-first-month-post-delivery
#16
Sümeyra Çoban, Ebru Yılmaz Keskin, Mahir İğde
OBJECTIVE: Exclusively breast-fed infants born to vitamin B12 (cobalamin, cbl)-deficient mothers can develop symptoms within a few months following delivery. The authors aimed to assess the relationship between maternal and infantile markers of cbl status. METHODS: In 240 full-term infants (age, 2-30 d) admitted to Samsun Maternity and Child Health Hospital and their mothers, complete blood count testing and serum cbl, folate and plasma total homocysteine (tHcy) measurements were performed...
January 6, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29209773/effect-of-8-week-oral-supplementation-with-3-%C3%A2%C2%B5g-cyano-b12-or-hydroxo-b12-in-a-vitamin-b12-deficient-population
#17
Eva Greibe, Namita Mahalle, Vijayshri Bhide, Sergey Fedosov, Christian W Heegaard, Sadanand Naik, Ebba Nexo
PURPOSE: We compare the effect of 8-week oral supplementation with cyano-B12 (currently used in vitamin pills) and hydroxo-B12 (predominant form in the diet) in a population with nutritional vitamin B12 deficiency. METHODS: Fifty-one healthy Indian adults with baseline serum cobalamin < 200 pmol/L were supplied for 8 weeks with daily oral supplements of 3-µg cyano-B12 (n = 15), 3-µg hydroxo-B12 (n = 16), or a placebo (n = 20). Blood at baseline, and each following week, was examined for total cobalamin, holotranscobalamin, methylmalonic acid, and homocysteine...
December 5, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/29189512/the-efficacy-of-oral-vitamin-b12-replacement-for-nutritional-vitamin-b12-deficiency
#18
Rabia G Sezer, Abdulkadir Bozaykut, Handan A Akoğlu, Gül N Özdemir
Standard treatment of vitamin B12 deficiency has not been well established in childhood, the ideal amount of supplemental vitamin B12 is not clear. Vitamin B12 deficiency is classically treated with intramuscular injections. In this study, we aimed to investigate the efficacy of oral therapy in children with vitamin B12 deficiency. Patients with serum cobalamin concentrations <300 pg/mL aged between 6 months to 18 years were included in this prospective study. Children were treated orally either with a combination of multivitamin tablet daily or vitamin B12 ampules...
March 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29172893/effect-of-age-sex-and-body-weight-on-the-serum-concentrations-of-cobalamin-and-folate-in-cats-consuming-a-consistent-diet
#19
Sarah A Hill, Nicholas J Cave, Sandra Forsyth
Objectives Multiple feline diseases involving the gastrointestinal tract, pancreas, liver and biliary tract are known to cause abnormal serum cobalamin and folate concentrations. Measuring the serum concentration of these vitamins can therefore be a helpful diagnostic tool. However, factors other than disease, in particular age, have also been suggested to have an effect on the serum concentration of cobalamin and folate. In previous studies, the dietary intake was not standardised, or even known, despite diet being the prinicpal source of both vitamins...
February 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29099902/correlation-between-the-fceai-and-diagnostic-parameters-in-chronic-enteropathies-in-147-cats-2006-2012
#20
Stefanie Mitze, Katharina Moser, Erik Teske, Wolf V Bomhard, Christian Stockhaus
OBJECTIVE: The Feline Chronic Enteropathy Activity Index (FCEAI) has been established as a quantitative index for disease activity in chronic enteropathies in cats. A definite diagnosis is aimed at histology with initial exclusion of extraintestinal causes by laboratory examinations, diagnostic imaging and endoscopy. The study aimed to examine diagnostic parameters and FCEAI in chronic gastroenteropathies. MATERIALS AND METHODS: A retrospective case review of 147 cats with chronic enteropathies was performed...
November 3, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
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