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https://www.readbyqxmd.com/read/27933616/efficacy-of-preoperative-ibuprofen-and-meloxicam-on-the-success-rate-of-inferior-alveolar-nerve-block-for-teeth-with-irreversible-pulpitis
#1
Yazdan Shantiaee, Sahar Javaheri, Amir Movahhedian, Sarah Eslami, Omid Dianat
OBJECTIVE: The purpose of this study was to determine whether premedication with ibuprofen or meloxicam increases the success rate of anaesthesia in teeth with irreversible pulpitis. MATERIALS AND METHODS: In this parallel, double-blind clinical trial, 92 patients diagnosed with irreversible pulpitis were randomly divided into four groups of 23 patients. The first group (the no-premedication group) received no premedication, the second group (the meloxicam group) received 7...
December 8, 2016: International Dental Journal
https://www.readbyqxmd.com/read/27933352/intracochlear-drug-delivery-in%C3%A2-combination-with-cochlear-implants-current-aspects
#2
S K Plontke, G Götze, T Rahne, A Liebau
Local drug application to the inner ear offers a number of advantages over systemic delivery. Local drug therapy currently encompasses extracochlear administration (i. e., through intratympanic injection), intracochlear administration (particularly for gene and stem cell therapy), as well as various combinations with auditory neurosensory prostheses, either evaluated in preclinical or clinical studies, or off-label. To improve rehabilitation with cochlear implants (CI), one focus is the development of drug-releasing electrode carriers, e...
December 8, 2016: HNO
https://www.readbyqxmd.com/read/27933228/who-inrud-prescribing-indicators-and-prescribing-trends-of-antibiotics-in-the-accident-and-emergency-department-of-bahawal-victoria-hospital-pakistan
#3
Muhammad Atif, Muhammad Azeem, Muhammad Rehan Sarwar, Samia Shahid, Sidra Javaid, Huria Ikram, Uzma Baig, Shane Scahill
A descriptive, retrospective and cross sectional study was conducted to assess the prescribing practices and antibiotic use patterns in the Accident and Emergency department of the Bahawal Victoria Hospital, Bahawalpur, Pakistan. A sample of 4320 prescriptions (systematic random sampling) was drawn out of a total of 1,080,000 prescriptions written during the period 1st January-31st December 2014. The standard World Health Organization/International Network for Rational Use of Drugs prescribing indicators were used to determine the prescribing practices of physicians...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27933175/hyperinsulinemic-hypoglycemia-associated-with-insulin-antibodies-caused-by-exogenous-insulin-analog
#4
Chih-Ting Su, Yi-Chun Lin
: Insulin antibodies (IA) associated with exogenous insulin administration seldom caused hypoglycemia and had different characteristics from insulin autoantibodies (IAA) found in insulin autoimmune syndrome (IAS), which was first described by Dr Hirata in 1970. The characteristic of IAS is the presence of insulin-binding autoantibodies and related fasting or late postprandial hypoglycemia. Here, we report a patient with type 1 diabetes mellitus under insulin glargine and insulin aspart treatment who developed recurrent spontaneous post-absorptive hyperinsulinemic hypoglycemia with the cause probably being insulin antibodies induced by exogenous injected insulin...
2016: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/27932881/preparation-and-antitumor-evaluation-of-self-assembling-oleanolic-acid-loaded-pluronic-p105-d-%C3%AE-tocopheryl-polyethylene-glycol-succinate-mixed-micelles-for-non-small-cell-lung-cancer-treatment
#5
Hao Wu, Qingxiang Zhong, Rongling Zhong, Houcai Huang, Zhi Xia, Zhongcheng Ke, Zhenhai Zhang, Jie Song, Xiaobin Jia
Oleanolic acid (OA) is a triterpenoid found in various fruits and vegetables and used in traditional Chinese medicine. OA plays a crucial role in the treatment of several cancers, but poor water solubility, low permeability, and significant efflux have limited its widespread clinical use. Vitamin E-d-α-tocopheryl polyethylene glycol succinate (vitamin E-TPGS) and Pluronic P105 were used to improve the solubility and permeability and to decrease the efflux of OA. OA-loaded mixed micelles were prepared by ethanol thin-film hydration...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27931762/comparison-of-intranasal-ketamine-versus-intravenous-morphine-in-reducing-pain-in-patients-with-renal-colic
#6
Mohammad Reza Farnia, Alireza Jalali, Elnaz Vahidi, Mehdi Momeni, Javad Seyedhosseini, Morteza Saeedi
BACKGROUND: Various drugs have been used to relieve abdominal pain in patients with renal colic. Ketamine is a popular choice as an analgesic. OBJECTIVE: To compare the effectiveness of intranasal (IN) ketamine versus intravenous (IV) morphine in reducing pain in patients with renal colic. METHODS: A randomized double-blind controlled trial was performed in 53 patients with renal colic recruited from the emergency department (ED) in 2015. Finally, 40 patients were enrolled in this study...
November 22, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27931319/subcutaneous-compared-with-intraperitoneal-ketaminexylazine-for-anesthesia-of-mice
#7
Maya Levin-Arama, Lital Abraham, Trevor Waner, Alon Harmelin, David M Steinberg, Tal Lahav, Mickey Harlev
Mice are commonly anesthetized intraperitoneally with a ketamine-xylazine (KX) solution. Although this route of administration allows rapid uptake of the injected drugs, its disadvantages and potential risks include pain, peritoneal irritation, and perforation of an abdominal organ; some of the risks depend on the operator's experience. We compared the efficacy of intraperitoneal and subcutaneous administration of KX in HSD:ICR, BALB/cOlaHsd, and C57BL/6JOlaHsd mice in terms of time to onset and duration of surgical anesthesia, procedure safety, and mortality...
November 2016: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/27931227/epigenetics-of-amphetamine-induced-sensitization-hdac5-expression-and-microrna-in-neural-remodeling
#8
Philip K Liu, Christina H Liu
BACKGROUND: Histone deacetylase (HDAC) activities modify chromatin structure and play a role in learning and memory during developmental processes. Studies of adult mice suggest HDACs are involved in neural network remodeling in brain repair, but its function in drug addiction is less understood. We aimed to examine in vivo HDAC5 expression in a preclinical model of amphetamine-induced sensitization (AIS) of behavior. We generated specific contrast agents to measure HDAC5 levels by in vivo molecular contrast-enhanced (MCE) magnetic resonance imaging (MRI) in amphetamine-naïve mice as well as in mice with AIS...
December 8, 2016: Journal of Biomedical Science
https://www.readbyqxmd.com/read/27931213/assessment-of-core-drug-use-indicators-using-who-inrud-methodology-at-primary-healthcare-centers-in-bahawalpur-pakistan
#9
Muhammad Atif, Muhammad Rehan Sarwar, Muhammad Azeem, Mubeen Naz, Salma Amir, Kashaf Nazir
BACKGROUND: Proper utilization of medicines is a critical component of pharmaceutical care plan. The aim of this study was to assess drug use pattern at ten primary healthcare centers (PHCCs) of the Bahawalpur district of the Punjab province of Pakistan by employing the WHO/INRUD core drug use indicators. METHODS: This was a descriptive, non-experimental and cross-sectional study. For the prescribing indicators, 1000 prescriptions (100 prescriptions per PHCC) were systematically sampled out of the total 290,000 prescriptions written during January to December 2014...
December 8, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27930972/the-anti-hyperplasia-of-mammary-gland-effect-of-protein-extract-hss-from-tegillarca-granosa
#10
Yuping Jia, Xiu Liu, Qingwen Jia, Wei Zhang, Chao Sun, Dongdong Yuan, Haoran Zhang, Ena Jiang, Dongshun Zhou
Tegillarca granosa Linnaeus, possesses various biological functions and has been used a Chinese traditional medicine more than one century, but there is no report about anti-hyperplasia of mammary gland (HMG) activity of drugs from T. granosa. In this study, we investigated the anti-HMG effect of protein extract named HSS from T. granosa. The HMG model of virgin female Sprague Dawley rats was prepared by injecting estrogen in the thigh muscle of the rats and progestogen consecutively. HMG rats were treated with either HSS or positive control drug by i...
December 5, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27930873/preprogrammed-long-term-systemic-pulsatile-delivery-of-parathyroid-hormone-to-strengthen-bone
#11
Ming Dang, Amy J Koh, Theodora Danciu, Laurie K McCauley, Peter X Ma
Parathyroid hormone (PTH) is the only US Food and Drug Administration (FDA)-approved anabolic agent for the treatment of osteoporosis. The anabolic action of PTH depends on the mode of PTH administration. Pulsatile administration promotes bone formation, however continuous PTH exposure results in bone resorption. In addition, the therapeutic effect of PTH is optimal when the dose and duration fit the therapeutic window. Current PTH treatment requires daily injection, which is neither a convenient nor a favorable choice of patients...
December 8, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27930590/low-mortality-but-increasing-incidence-of-staphylococcus-aureus-endocarditis-in-people-who-inject-drugs-experience-from-a-swedish-referral-hospital
#12
Hilmir Asgeirsson, Anders Thalme, Ola Weiland
Staphylococcus aureus is a leading cause of infective endocarditis in people who inject drugs (PWID). The management of S aureus endocarditis (SAE) in PWID can be problematic. The objective of this retrospective observational study was to assess the epidemiology, clinical characteristics, and mortality of S aureus endocarditis (SAE) in PWID in Stockholm, Sweden.The Department of Infectious Diseases at the Karolinska University Hospital serves as a regional referral center for drug users with severe infections...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27930390/a-novel-approach-for-the-control-of-inflammatory-pain-prostaglandin-e2-complexation-by-randomly-methylated-%C3%AE-cyclodextrins
#13
Reine-Solange Sauer, Heike Lydia Rittner, Norbert Roewer, Tamás Sohajda, Sergey Shityakov, Alexander Brack, Jens-Albert Broscheit
BACKGROUND: Inhibitors of cyclooxygenase, which block the formation of prostaglandin (PG) E2, are the standard treatment of inflammatory pain. These drugs, however, have serious gastrointestinal, renal, and cardiovascular side effects that limit their clinical use. Cyclodextrins are neutral glucose oligomers that form a hydrophilic outer and a hydrophobic interior cavity used to carry hydrophilic substances. Methyl-β-cyclodextrins are used currently in several drugs as enhancers and also to deliver PGs...
December 8, 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27930371/effect-of-low-concentration-nonmydriatic-selective-alpha-adrenergic-agonist-eyedrops-on-upper-eyelid-position
#14
Taís B Mendonça, Atauíne P Lummertz, Francisco J L Bocaccio, Fernando Procianoy
BACKGROUND: Ptosis after botulinum toxin injection is a disturbing complication. Decongestant and antiglaucoma eyedrops are frequently prescribed for temporary improvement of eyelid ptosis. Although frequently cited on informal communications, the effect of these drugs on eyelid position has never been compared in a formal study. OBJECTIVE: To measure the effect of low-concentration, nonmydriatic selective alpha agonist eyedrops on upper eyelid position. METHODS AND MATERIALS: This nonrandomized clinical trial enrolled 20 healthy subjects aged 18 to 50 years...
December 2, 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27930328/estimating-uncertainty-in-respondent-driven-sampling-using-a-tree-bootstrap-method
#15
Aaron J Baraff, Tyler H McCormick, Adrian E Raftery
Respondent-driven sampling (RDS) is a network-based form of chain-referral sampling used to estimate attributes of populations that are difficult to access using standard survey tools. Although it has grown quickly in popularity since its introduction, the statistical properties of RDS estimates remain elusive. In particular, the sampling variability of these estimates has been shown to be much higher than previously acknowledged, and even methods designed to account for RDS result in misleadingly narrow confidence intervals...
December 7, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27929598/sclerotic-effect-of-oxytetracycline-on-the-submandibular-gland-an-experimental-model
#16
Oğuz Güçlü, Asli Muratli, Deniz Arik, Kazım Tekin, Halil Erdogan, Fevzi Sefa Dereköy
Oxytetracycline has been suggested as an alternate therapy for chronic recurrent sialadenitis and sialorrhea. We conducted an experimental study to investigate the sclerotic effect of this drug on the submandibular gland by histopathologic methods. Our subjects were 20 New Zealand white rabbits, which were divided into two groups of 10. The right submandibular gland of the rabbits in the active-treatment group was injected with 0.3 ml of oxytetracycline (100 mg/ml), and that of the controls was injected with saline...
December 2016: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/27929348/shallow-discounting-of-delayed-cocaine-by-male-rhesus-monkeys-when-immediate-food-is-the-choice-alternative
#17
Sally L Huskinson, Joel Myerson, Leonard Green, James K Rowlett, William L Woolverton, Kevin B Freeman
Huskinson et al. (2015) recently examined delay discounting in monkeys choosing between an immediate drug (cocaine) reinforcer and a delayed nondrug (food) reinforcer. The present experiment examined the reverse situation: choice between immediate nondrug (food) and delayed drug (cocaine) reinforcers. Whereas the former choice situation exemplifies drug abuse from a delay-discounting perspective, our interest in the latter choice situation is derived from the observation that drug abusers, who characteristically are associated with impulsive choice, typically must devote considerable time to procuring drugs, often at the expense of immediate nondrug alternatives...
December 2016: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27928947/oral-glucose-lowering-drugs-and-cardiovascular-outcomes-from-the-negative-record-and-accord-to-neutral-tecos-and-promising-empa-reg
#18
C Tsioufis, E Andrikou, C Thomopoulos, N Papanas, D Tousoulis
Cardiovascular (CV) morbidity and mortality are higher among patients with diabetes mellitus type 2 (T2DM), particularly those with concomitant CV diseases, compared with other populations. In patients with T2DM, intensive glucose lowering reduces microvascular disease, but has a smaller and debated effect on CV events or mortality. In this setting, the US Food and Drug Administration (FDA) required in 2008 that all new agents for the treatment of T2DM should be evaluated in terms of CV safety. Metformin has long been established as first-line pharmacological therapy in patients with T2DM, due to its proven beneficial CV effects...
December 8, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27928926/clinical-observation-of-adverse-drug-reactions-to-nonionic-iodinated-contrast-media-in-population-with-underlying-diseases-and-risk-factors
#19
Xue Li, Heng Liu, Li Zhao, Junling Liu, Li Cai, Lei Liu, Weiguo Zhang
OBJECTIVES: To determine the adverse drug reactions (ADRs) profile of nonionic iodinated contrast media (NICMs) in population with underlying diseases and risk factors, and to provide guidance for more safe and rational use of ICMs in clinic. METHODS: Data from 120,822 cases who underwent enhanced CT examination in our hospital from January 2014 to March 2016 were collected. A standardized case report form (CRF) was used for data collection and analysis. RESULTS: The incidence of ADRs was 0...
December 8, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27928893/outsmarted-by-nooptropics-an-investigation-into-the-thermal-degradation-of-modafinil-modafinic-acid-adrafinil-crl-40-940-and-crl-40-941-in-the-gc-injector-formation-of-1-1-2-2-tetraphenylethane-and-its-tetra-fluoro-analog
#20
Geraldine Dowling, Pierce V Kavanagh, Brian Talbot, John O'Brien, Gary Hessman, Gavin McLaughlin, Brendan Twamley, Simon D Brandt
2-[(Diphenylmethyl)sulfinyl]acetamide (modafinil) is commonly prescribed for the treatment of narcolepsy and increasing popularity and off-label use as a cognitive enhancer resulted in a reputation as an intelligence boosting 'wonder drug'. Common alternatives available from online shops and other retail outlets include 2-[(diphenylmethyl)sulfinyl]-N-hydroxyacetamide (adrafinil), 2-{[bis(4-fluorophenyl)methyl]sulfinyl}acetamide (CRL-40,940), 2-{[bis(4-fluorophenyl)methyl]sulfinyl}-N-hydroxyacetamide (CRL-40,941) and N-methyl-4,4-difluoro-modafinil (modafiendz), respectively...
December 8, 2016: Drug Testing and Analysis
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