keyword
MENU ▼
Read by QxMD icon Read
search

Inject drugs

keyword
https://www.readbyqxmd.com/read/29458102/%C3%AE-irradiated-chitosan-based-injectable-hydrogels-for-controlled-release-of-drug-montelukast-sodium
#1
Sadaf Hafeez, Atif Islam, Nafisa Gull, Abbas Ali, Shahzad Maqsood Khan, Saba Zia, Kalsoom Anwar, Saba Urooge Khan, Tahir Jamil
Novel pH-sensitive γ-irradiated low molecular weight chitosan (CS) (pre-irradiated) and poly (vinyl alcohol) (PVA) blended injectable hydrogels, crosslinked with varying concentrations of glycerol, were fabricated for drug delivery application. The effect of low molecular weight irradiated CS on controlled drug release was evaluated to address the problem of higher viscosity and lower solubility of high molecular weight CS. The FTIR spectra of hydrogels depicted the presence of all the incorporated functional groups and the developed interactions (physical and chemical)...
February 16, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29458050/investigation-of-metabolic-stability-of-the-novel-alk-inhibitor-brigatinib-by-liquid-chromatography-tandem-mass-spectrometry
#2
Hany W Darwish, Adnan A Kadi, Mohamed W Attwa, Halah S Almutairi
Brigatinib (BGB) belongs to a class of drugs called ALK inhibitor. On April 28, 2017, BGB has been approved by U.S. FDA for use in metastatic ALK-positive NSCLC. A fast, specific, sensitive and validated LC-MS/MS method was developed for the quantification of BGB in human plasma matrix. This method was applied successfully to study metabolic stability of BGB. Reversed phase (C18 column) and isocratic binary mobile phase (55% 0.1% formic acid: 45% ACN) were used for chromatographic separation of BGB and ponatinib (IS)...
February 16, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29457989/propylthiouracil-induced-anti-neutrophil-cytoplasmic-antibody-associated-vasculitis-mimicking-kawasaki-disease
#3
Yoshihiro Aoki, Katsuhiko Kitazawa, Hironobu Kobayashi
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is rare in children and is characterised as necrotising vasculitis predominantly affecting small and medium-sized vessels. Propylthiouracil (PTU), an antithyroid drug, has been implicated in drug-induced AAV. In contrast, Kawasaki disease (KD) is a common systemic vasculitis, typically observed in children, which affects the medium-sized vessels, including the coronary arteries. An 11-year-old girl who developed AAV while receiving PTU therapy for Graves' disease is described...
February 19, 2018: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/29457630/combination-drug-delivery-via-multilamellar-vesicles-enables-targeting-of-tumor-cells-and-tumor-vasculature
#4
Yarong Liu, Yu Jeong Kim, Natnaree Siriwon, Jennifer A Rohrs, Zhiqiang Yu, Pin Wang
Blood vessel development is critical for the continued growth and progression of solid tumors and, therefore, makes an attractive target for improving cancer therapy. Indeed, vascular-targeted therapies have been extensively explored but they have shown minimal efficacy as monotherapies. Combretastatin A4 (CA-4) is a tubulin-binding vascular disrupting agent that selectively targets the established tumor endothelium, causing rapid vascular beak down. Despite its potent anticancer potential, the drug has dose-limiting side effects, particularly in the form of cardiovascular toxicity...
February 19, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29457594/biodistribution-of-colloidal-gold-nanoparticles-after-intravenous-injection-effects-of-pegylation-at-the-same-particle-size
#5
Issei Takeuchi, Haruhiko Onaka, Kimiko Makino
BACKGROUND: Recently, polyethylene glycol (PEG) modified gold nanoparticles have been studied to maintaining long-term stability in biological fluids. Its biodistribution was also reported, however, comparison of bare gold nanoparticles and PEGylated gold nanoparticles with equal particle size is not sufficient. OBJECTIVE: We prepared bare gold nanoparticles and PEGylated gold nanoparticles with diameters of 20-30-nm or 50-nm to avoid the influence of particle diameter, and studied their biodistribution in the mouse...
2018: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/29457489/shingrix-the-new-adjuvanted-recombinant-herpes-zoster-vaccine
#6
Stephanie F James, Elias B Chahine, Allana J Sucher, Cassandra Hanna
OBJECTIVES: To review the immunogenicity, efficacy, and safety of the herpes zoster subunit vaccine (HZ/su) for use in adult patients for the prevention of shingles. DATA SOURCES: A literature search through PubMed was conducted (June 2008 to October 2017) using the terms shingles vaccine and varicella zoster virus. References from retrieved articles and the prescribing information were also reviewed for any additional material. STUDY SELECTION/DATA EXTRACTION: The literature search was limited to human studies published in English...
February 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29456388/analgesic-properties-of-nigella-sativa-and-eucheuma-cottonii-extracts
#7
Amira Zakaria, Mohammad Rohani Jais, Reezal Ishak
Background: This study investigates the analgesic properties of the aqueous extracts of Nigella sativa and Eucheuma cottonii in mice. The analgesic properties of both extracts were evaluated in an experimental model of acetic acid-induced writhing test. Materials and Methods: The mice were divided into four different groups and received the test extracts and the standard drug (aspirin) for 14 days via force-feeding. On day 15, the mice were injected with 5% acetic acid, and the number of abdominal constriction and elongation of hind limb (writhes) were counted for 20 min...
January 2018: Journal of Natural Science, Biology, and Medicine
https://www.readbyqxmd.com/read/29456352/efficacy-of-botulinum-toxin-type-a-in-trigeminal-neuralgia-in-a-south-asian-cohort
#8
Manjula Chandragomi Caldera, Sameera Jayan Senanayake, Sujith Priyankara Perera, Nadeeke Nidhan Perera, Ranjanie Gamage, Inuka Kishara Gooneratne
Introduction: The antinociceptive effect of botulinum toxin-A (BTX-A) in trigeminal neuralgia (TN) has been described. We evaluated effects of BTX-A in relieving pain in patients with refractory TN at National Hospital of Sri Lanka. Materials and Methods: Pain in patients with TN was assessed using a visual analog from 0 to 10. Three months after commencement of drug therapy with ≥2 drugs including one first-line drug (carbamazepine/oxcarbazepine), pain scores were re-assessed...
January 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29456204/renoprotective-effect-of-nigella-sativa-against-cisplatin-induced-nephrotoxicity-and-oxidative-stress-in-rat
#9
Sara Hosseinian, Mousa-Al-Reza Hadjzadeh, Noma Mohamadian Roshan, Majid Khazaei, Samira Shahraki, Reza Mohebbati, Abolfazl Khajavi Rad
Cisplatin is one of the important antineoplastic drugs. Its clinical use has been restricted due to severe kidney toxicity. Nigella sativa (N. sativa) is an herbaceous plant with many pharmacologic effects. In the present study, we evaluated the protective effects of aqueous-ethanolic extract of N. sativa and Vitamin E on cisplatin-induced nephrotoxicity in rats. Eighty male rats were divided into eight groups: control, cisplatin (6 mg/kg; ip), preventive Vitamin E (100 mg/kg), preventive N. sativa (100,200 mg/kg), preventive + treatment Vitamin E, and preventive + treatment N...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29456019/exosomes-serve-as-nanoparticles-to-deliver-anti-mir-214-to-reverse-chemoresistance-to-cisplatin-in-gastric-cancer
#10
Xinyi Wang, Haiyang Zhang, Ming Bai, Tao Ning, Shaohua Ge, Ting Deng, Rui Liu, Le Zhang, Guoguang Ying, Yi Ba
Chemoresistance is one of the causes of adverse effects in gastric cancer, including a poor response to cisplatin (DDP). Exosomes loaded with microRNA (miRNA), mRNA, and other non-coding RNAs could regulate drug resistance. Exo-anti-214 was extracted and verified. A Cell Counting Kit-8 (CCK-8) cell viability assay, flow cytometry, and transwell and immunofluorescence assays were performed to determine whether exo-anti-214 could sensitize cells to DDP in vitro. A combination of intravenously injected exo-anti-214 and intraperitoneal DDP was utilized in vivo...
January 8, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29456012/injectable-and-body-temperature-sensitive-hydrogels-based-on-chitosan-and-hyaluronic-acid-for-ph-sensitive-drug-release
#11
Wei Zhang, Xin Jin, Heng Li, Run-Run Zhang, Cheng-Wei Wu
Hydrogels based on chitosan/hyaluronic acid/β-sodium glycerophosphate demonstrate injectability, body temperature sensitivity, pH sensitive drug release and adhesion to cancer cell. The drug (doxorubicin) loaded hydrogel precursor solutions are injectable and turn to hydrogels when the temperature is increased to body temperature. The acidic condition (pH 4.00) can trigger the release of drug and the cancer cell (Hela) can adhere to the surface of the hydrogels, which will be beneficial for tumor site-specific administration of drug...
April 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29456009/novel-in-situ-forming-hydrogel-based-on-xanthan-and-chitosan-re-gelifying-in-liquids-for-local-drug-delivery
#12
Jinjian Huang, Youming Deng, Jianan Ren, Guopu Chen, Gefei Wang, Feng Wang, Xiuwen Wu
Injectable hydrogels have been an attractive topic in biomaterials. However, during gelation in vivo, they are easy to disperse due to tissue exudates, thus leading to failure of controlled drug release. To solve this problem, we present a novel polysaccharide-based injectable hydrogel via self-crosslinking of aldehyde-modified xanthan (Xan-CHO) and carboxymethyl-modified chitosan (NOCC). The physical properties were optimized by adjusting the mass ratio of Xan-CHO and NOCC. Experiments revealed that this material exhibited the characteristics of self-healing, anti-enzymatic hydrolysis, biocompatibility and biodegradability...
April 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29455562/spatiotemporal-characteristics-of-the-hiv-1-crf02_ag-crf63_02a1-epidemic-in-russia-and-central-asia
#13
Evangelia-Georgia Kostaki, Timokratis Karamitros, Marina Bobkova, Martha Oikonomopoulou, Gkikas Magiorkinis, Federico Garcia, Angelos Hatzakis, Dimitrios Paraskevis
BACKGROUND: Eastern European countries including Russia, Ukraine and other former Soviet Union (FSU) countries have experienced an HIV epidemic spreading mostly among people who inject drugs (PWID). We aimed to investigate the origin and the dispersal patterns of HIV-1 CRF02_AG in Russia and other FSU countries. METHODS: We studied 136 CRF02_AG sequences originating from Russia, and FSU countries along with a globally sampled dataset of 3,580 CRF02_AG sequences...
February 17, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29455094/emodin-attenuates-titanium-particle-induced-osteolysis-and-rankl-mediated-osteoclastogenesis-through-the-suppression-of-ikk-phosphorylation
#14
Juehong Li, Yamin Li, Xiaochun Peng, Bin Li, Xiangwei Yuan, Yunsu Chen
Aseptic loosening due to wear particles is a serious challenge for orthopedic surgeons, sabotaging the long-term success of total joint arthroplasty. The existing treatments for aseptic loosening are still far from satisfactory, necessitating more aggressive drug exploration. Here, we examined the effect of emodin on titanium particle-induced osteolysis and further investigated its underlying mechanism in vivo and in vitro. Thirty-two C57BL/6 mice were randomly assigned into four groups: the Sham group (sham operation with vehicle injection), Vehicle group (titanium particle treatment with vehicle injections), Low group (titanium particle treatment with injections of 10 mg/kg/day emodin) and High group (titanium particle treatment with injections of 50 mg/kg/day emodin)...
February 15, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29454841/hypocretin-orexin-deficiency-decreases-cocaine-abuse-liability
#15
Nadia Steiner, Clara Rossetti, Takeshi Sakurai, Masashi Yanagisawa, Luis de Lecea, Pierre J Magistretti, Olivier Halfon, Benjamin Boutrel
Compelling evidence indicates that hypocretin/orexin signaling regulates arousal, stress and reward-seeking behaviors. However, most studies on drug reward-related processes have so far described the effects of pharmacological blockers disrupting hypocretin/orexin transmission. We report here an extensive study on cocaine-related behaviors in hypocretin/orexin-deficient mice (KO) and their heterozygous (HET) and wildtype (WT) littermates. We evaluated behavioral sensitization following repeated administrations and preference for an environment repeatedly paired with cocaine injections (15 mg/kg)...
February 15, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29454755/evaluation-of-antidiabetic-potential-of-steroidal-alkaloid-of-sarcococca-saligna
#16
Naeem Ullah Jan, Amjad Ali, Bashir Ahmad, Naveed Iqbal, Achyut Adhikari, Inayat-Ur-Rehman, Abid Ali, Safdar Ali, Azra Jahan, Hamid Ali, Ijaz Ali, Anwar Ullah, Syed Ghulam Musharraf
The demand for natural medicines has increased because of their limited adverse effects. The aim of study is to explore the antidiabetic potential of isolated steroidal alkaloid from Sarcococca saligna in streptozotocin induced diabetic rats. To determine the antidiabetic activity of steroidal alkaloids, diabetes was induced in rats by injecting streptozotocin intraperitoneally at a dose of 40 mg/Kg. After a week of STZ injection the treatment were started and the 8th day was considered as the 1st day of treatment and up to four weeks the rats were treated with steroidal alkaloids...
February 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29454236/stingel-controlled-release-of-a-cyclic-dinucleotide-for-enhanced-cancer-immunotherapy
#17
David G Leach, Neeraja Dharmaraj, Stacey L Piotrowski, Tania L Lopez-Silva, Yu L Lei, Andrew G Sikora, Simon Young, Jeffrey D Hartgerink
Recent advancements in the field of immunotherapy have yielded encouraging results for the treatment of advanced cancers. Cyclic dinucleotides (CDNs) are a powerful new class of immunotherapy drugs known as STING (Stimulator of Interferon Genes) agonists, currently in clinical trials. However, previous studies of CDNs in murine cancer models have required multiple injections, and improve survival only in relatively nonaggressive tumor models. Therefore, we sought to improve the efficacy of CDN immunotherapy by developing a novel biomaterial we call "STINGel...
February 6, 2018: Biomaterials
https://www.readbyqxmd.com/read/29453807/tunable-poly-methacrylic-acid-co-acrylamide-nanoparticles-through-inverse-emulsion-polymerization
#18
Justin X Zhong, John R Clegg, Eric W Ander, Nicholas A Peppas
Environmentally responsive biomaterials have played key roles in the design of biosensors and drug delivery vehicles. Their physical response to external stimuli, such as temperature or pH, can transduce a signal or trigger the release of a drug. In this work, we designed a robust, highly tunable, pH responsive nanoscale hydrogel system. We present the design and characterization of poly((methacrylic acid) - co - acrylamide) hydrogel nanoparticles, crosslinked with methylenebisacrylamide, through inverse emulsion polymerization...
February 17, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29453801/regional-deposition-of-nasal-sprays-in-adults-a-wide-ranging-computational-study
#19
Milad Kiaee, Herbert Wachtel, Michelle L Noga, Andrew R Martin, Warren H Finlay
The present work examines regional deposition within the nose for nasal sprays over a large and wide ranging parameter space by using numerical simulation. A set of seven realistic adult nasal airway geometries was defined based on Computed Tomography (CT) images. Deposition in six regions of each nasal airway geometry (the vestibule, valve, anterior turbinate, posterior turbinate, olfactory, and nasopharynx) was determined for varying particle diameter, spray cone angle, spray release direction, particle injection speed, and particle injection location...
February 17, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29453467/loading-dose-only-versus-standard-dose-magnesium-sulfate-seizure-prophylaxis-in-severe-pre-eclamptic-women
#20
Surya Prasad Rimal, Pappu Rijal, Rabindra Bhatt, Kriti Thapa
INTRODUCTION: Magnesium sulfate is the drug of choice for prevention of seizures in the pre-eclamptic woman. There is no agreement in the published randomized trials regarding the optimal time to initiate magnesium sulfate, the dose to use (both loading and maintenance) as well as the duration of therapy. The objective of this study is to determine whether magnesium sulfate prophylaxis is needed for up to 24 hours postpartum in all patients with severe pre-eclampsia for the prevention of seizure...
October 2017: JNMA; Journal of the Nepal Medical Association
keyword
keyword
115089
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"