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https://www.readbyqxmd.com/read/28454445/role-of-reactive-oxygen-species-in-the-anticancer-activity-of-botanicals-comparing-sensitivity-profiles
#1
Zoya Cohen, Yair Maimon, Noah Samuels, Raanan Berger
Numerous botanicals have been shown to exhibit in vitro and in vivo anticancer activity, some of which is the result of the induction of reactive oxygen species (ROS) in cancer cells with a high ROS content. The present study compared sensitivities to a series of botanicals among cancer cell lines, using an XTT viability test, in order to create a specific cancer-herb profile. Of the 27 botanicals screened, 10 exhibited a cytotoxic effect, 7 of which were ROS-mediated. The sensitivity profiles of the ROS-inducing botanicals in 10 cancer cell lines were similar, unlike 3 cytotoxic ROS-independent botanicals that displayed divergent botanical-specific profiles...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454341/the-role-of-fadd-in-pancreatic-cancer-cell-proliferation-and-drug-resistance
#2
Rong Zhang, Yingting Liu, Kahina Hammache, Liangqiang He, Bo Zhu, Wei Cheng, Zi-Chun Hua
Pancreatic cancer has one of the poorest patient outcomes and is highly resistant to chemotherapy. Identifying the molecular mechanisms involved in drug resistance is critical in the development of novel strategies to treat pancreatic cancer. The results of the present study demonstrate that Fas-associated death domain protein (FADD), a classical adaptor protein mediating apoptotic stimuli-induced cell death, protects pancreatic cancer cells from drug-induced apoptosis. In contrast to its classical apoptotic roles, it was observed that FADD is required for pancreatic cancer cell proliferation and that it is overexpressed to varying degrees in various types of pancreatic cancer cell...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28453613/functional-characterization-of-the-human-speech-articulation-network
#3
Alexandra Basilakos, Kimberly G Smith, Paul Fillmore, Julius Fridriksson, Evelina Fedorenko
A number of brain regions have been implicated in articulation, but their precise computations remain debated. Using functional magnetic resonance imaging, we examine the degree of functional specificity of articulation-responsive brain regions to constrain hypotheses about their contributions to speech production. We find that articulation-responsive regions (1) are sensitive to articulatory complexity, but (2) are largely nonoverlapping with nearby domain-general regions that support diverse goal-directed behaviors...
April 27, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28453570/contrasting-effects-of-heat-pulses-on-different-trophic-levels-an-experiment-with-a-herbivore-parasitoid-model-system
#4
Stijn J J Schreven, Enric Frago, Annemiek Stens, Peter W de Jong, Joop J A van Loon
Under predicted global climate change, species will be gradually exposed to warmer temperatures, and to a more variable climate including more intense and more frequent heatwaves. Increased climatic variability is expected to have different effects on species and ecosystems than gradual warming. A key challenge to predict the impact of climate change is to understand how temperature changes will affect species interactions. Herbivorous insects and their natural enemies belong to some of the largest groups of terrestrial animals, and thus they have a great impact on the functioning of ecosystems and on the services these ecosystems provide...
2017: PloS One
https://www.readbyqxmd.com/read/28453522/potential-biological-pathways-linking-type-d-personality-and-poor-health-a-cross-sectional-investigation
#5
Vera K Jandackova, Julian Koenig, Marc N Jarczok, Joachim E Fischer, Julian F Thayer
BACKGROUND: Type-D personality, defined as a combination of high negative affect and high social isolation, has been associated with poor health outcomes. However, pathways underlying this association are largely unknown. We investigated the relationship between Type-D personality and several biological and behavioral pathways including the autonomic nervous system, the immune system, glucose regulation and sleep in a large, apparently healthy sample. METHODS: Data from a total of 646 respondents (age 41...
2017: PloS One
https://www.readbyqxmd.com/read/28453476/reduced-cerebral-blood-flow-in-mild-cognitive-impairment-assessed-using-phase-contrast-mri
#6
Reyes García de Eulate, Irene Goñi, Alvaro Galiano, Marta Vidorreta, Miriam Recio, Mario Riverol, José L Zubieta, María A Fernández-Seara
There is increasing evidence of a vascular contribution to Alzheimer's disease (AD). In some cases, prior work suggests that chronic brain hypoperfusion could play a prime pathogenic role contributing to the accumulation of amyloid-β,while other studies favor the hypothesis that vascular dysfunction and amyloid pathology are independent, although synergistic, mechanisms contributing to cognitive impairment. Vascular dysfunction can be evaluated by assessing cerebral blood flow impairment. Phase contrast velocity mapping by MRI offers a non-invasive means of quantifying the total inflow of blood to the brain...
April 25, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28453457/plasma-expression-of-the-intestinal-metaplasia-markers-cdh17-and-tff3-in-patients-with-gastric-cancer
#7
Boram Choi, Hyuk-Joon Lee, Jimin Min, Hwi-Nyeong Choe, Yun-Suk Choi, Young-Gil Son, Hye-Seong Ahn, Yun-Suhk Suh, James R Goldenring, Han-Kwang Yang
BACKGROUND: Few reliable blood markers are available for detecting gastric cancer, mainly owing to the heterogeneity of the cancer. OBJECTIVE: To establish gastric cancer diagnostic markers, we evaluated the levels of plasma cadherin 17 (CDH17) and trefoil factor 3 (TFF3), which are secretory proteins and known markers for intestinal metaplasia (IM), in patients with gastric cancer. METHOD: The protein expression level was analyzed in blood plasma samples from 111 gastric cancer patients and 44 healthy individuals, using a sandwich ELISA kit, followed by statistical analyses...
April 21, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28449127/effects-of-emotional-valence-and-arousal-on-the-voice-perception-network
#8
Patricia E G Bestelmeyer, Sonja A Kotz, Pascal Belin
Several theories conceptualise emotions along two main dimensions: valence (a continuum from negative to positive) and arousal (a continuum that varies from low to high). These dimensions are typically treated as independent in many neuroimaging experiments, yet recent behavioural findings suggest that they are actually interdependent. This result has impact on neuroimaging design, analysis and theoretical development. We were interested in determining the extent of this interdependence both behaviourally and neuroanatomically, as well as teasing apart any activation that is specific to each dimension...
April 25, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28449073/genetics-of-phenotypic-plasticity-and-biomass-traits-in-hybrid-willows-across-contrasting-environments-and-years
#9
Sofia Berlin, Henrik R Hallingbäck, Friderike Beyer, Nils-Erik Nordh, Martin Weih, Ann-Christin Rönnberg-Wästljung
Background and Aims: Phenotypic plasticity can affect the geographical distribution of taxa and greatly impact the productivity of crops across contrasting and variable environments. The main objectives of this study were to identify genotype-phenotype associations in key biomass and phenology traits and the strength of phenotypic plasticity of these traits in a short-rotation coppice willow population across multiple years and contrasting environments to facilitate marker-assisted selection for these traits...
April 25, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28448309/clinical-feasibility-of-3-dimensional-magnetic-resonance-cholangiopancreatography-using-compressed-sensing-comparison-of-image-quality-and-diagnostic-performance
#10
Jeong Hee Yoon, Sang Min Lee, Hyo-Jin Kang, Elisabeth Weiland, Esther Raithel, Yohan Son, Berthold Kiefer, Jeong Min Lee
OBJECTIVE: The aim of this study was to evaluate the clinical feasibility of fast 3-dimensional (3D) magnetic resonance cholangiopancreatography (MRCP) using compressed sensing (CS) in comparison with conventional navigator-triggered 3D-MRCP. MATERIALS AND METHODS: This retrospective study was approved by our institutional review board, and the requirement of informed consent was waived. A total of 84 patients (male-to-female ratio, 41:43; mean age, 47.3 ± 18.8 years) who underwent conventional 3D navigator-triggered T2-weighted MRCP using sampling perfection with application optimized contrasts (SPACE) and fast 3D MRCP using SPACE with high undersampling combined with CS reconstruction (CS SPACE; CS-MRCP) on a 3 T scanner were included...
April 26, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28447383/manganese-transport-is-essential-for-n2-fixation-by-rhizobium-leguminosarum-in-bacteroids-from-galegoid-but-not-phaseoloid-nodules
#11
Graham Hood, Vinoy Ramachandran, Alison East, J Allan Downie, Philip S Poole
Rhizobium leguminosarum has two high-affinity Mn(2+) transport systems encoded by sitABCD and mntH. In symbiosis, sitABCD and mntH were expressed throughout nodules and also strongly induced in Mn(2+) -limited cultures of free-living cells. Growth of a sitA mntH double mutant was severely reduced under Mn(2+) limitation and sitA and mntH single mutants were more sensitive to oxidative stress. The double sitA mntH mutant of R. leguminosarum was unable to fix nitrogen (Fix(-) ) with legumes belonging to the galegoid clade (Pisum sativum, Vicia faba and Vicia hirsuta)...
April 26, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28447341/chemotherapy-alone-versus-chemotherapy-plus-radiotherapy-for-adults-with-early-stage-hodgkin-lymphoma
#12
REVIEW
Oliver Blank, Bastian von Tresckow, Ina Monsef, Lena Specht, Andreas Engert, Nicole Skoetz
BACKGROUND: Combined modality treatment consisting of chemotherapy followed by localised radiotherapy is the standard treatment for patients with early stage Hodgkin lymphoma (HL). However, due to long- term adverse effects such as secondary malignancies the role of radiotherapy has been questioned recently and some clinical study groups advocate chemotherapy only for this indication. OBJECTIVES: To assess the effects of chemotherapy alone compared to chemotherapy plus radiotherapy in adults with early stage HL ...
April 27, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28447241/abbreviated-breast-dynamic-contrast-enhanced-mr-imaging-for-lesion-detection-and-characterization-the-experience-of-an-italian-oncologic-center
#13
Antonella Petrillo, Roberta Fusco, Mario Sansone, Marilena Cerbone, Salvatore Filice, Annamaria Porto, Maria Rosaria Rubulotta, Massimiliano D'Aiuto, Franca Avino, Maurizio Di Bonito, Gerardo Botti
BACKGROUND: To evaluate the performance of an abbreviated dynamic contrast-enhanced MR imaging (MRI) protocol for breast cancer detection; a comparison with the complete diagnostic protocol has been conducted. METHODS: A retrospective analysis on 508 patients was performed. Abbreviated protocol (AP) included one pre-contrast and the first post-contrast T1-weighted series. Complete protocol (CP) consisted of four post-contrast and one pre-contrast T1-weighted series...
April 26, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28446919/high-nitrogen-supply-induces-physiological-responsiveness-to-long-photoperiod-in-barley
#14
Jian Zeng, Huajin Sheng, Yang Liu, Yao Wang, Yi Wang, Houyang Kang, Xing Fan, Lina Sha, Shu Yuan, Yonghong Zhou
Photoperiod and nutrient nitrogen (N) supply influence the growth, development, and productivity of crops. This study examined the physiological, biochemical, and morpho-anatomical traits of NA5 and NA9, two barley cultivars with contrasting photoperiod lengths, under the combined treatment of photoperiod regime and N supply. Under long photoperiod, high N supply decreased net photosynthesis; decreased chlorophyll a and chlorophyll a/b; decreased ascorbate peroxidase (APX), catalase (CAT), and superoxide dismutase (SOD) activities; decreased ascorbate, glutathione, soluble protein, and soluble sugar; destroyed mesophyll cell integrity; and increased [Formula: see text], malondialdehyde, and proline in both NA5 and NA9...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28446838/visual-functions-of-workers-exposed-to-organic-solvents-in-petrochemical-industries
#15
R Indhushree, R Monica, K Coral, Narayanasamy Angayarkanni, R Punitham, B M Subburathinam, R Krishnakumar, P P Santanam
AIM: The purpose of this study was to evaluate the visual functions of workers exposed to organic solvents in petrochemical industries. MATERIALS AND METHODS: Thirty workers from the petroleum refinery and 30 age-matched controls (mean age) were recruited. Visual functions and occupational exposure levels were assessed among both the groups. Visual acuity, contrast sensitivity, color vision, and visual fields were evaluated at the workplace. The biological samples, namely blood and urine, were collected at the workplace and transported to the laboratory for analysis...
September 2016: Indian Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28446669/salivary-blockade-protects-the-lower-respiratory-tract-of-mice-from-lethal-influenza
#16
Karen Ivinson, Georgia Deliyannis, Leanne McNabb, Lara Grollo, Brad Gilbertson, David Jackson, Lorena E Brown
It is possible to model progression of influenza virus from the upper respiratory tract to the lower respiratory tract in the mouse using viral inoculum delivered in a restricted manner to the nose. In this model, infection with the A/Udorn/307/72 (Udorn) strain of virus results ultimately in high viral titres in both the trachea and lungs. In contrast, the A/Puerto Rico/8/34 (PR8) strain causes an infection that is almost entirely limited to the nasal passages. The factors that govern the progression of virus down the respiratory tract are not well understood...
April 26, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28446585/activation-mechanism-of-a-neuromodulator-gated-pacemaker-ionic-current
#17
Michael Gray, Daniel Hector Daudelin, Jorge Golowasch
The neuromodulator-gated current (IMI) found in the crab stomatogastric ganglion is activated by neuromodulators that are essential to induce the rhythmic activity of the pyloric network in this system. One of these neuromodulators is also known to control the correlated expression of voltage-gated ionic currents in pyloric neurons as well as synaptic plasticity and strength. Thus, understanding the mechanism by which neuromodulator receptors activate IMI should provide insights not only into how oscillations are initiated, but also into how other processes, and currents not directly activated by them, are regulated...
April 26, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28446461/developmental-changes-of-contractile-responses-to-cholinergic-stimuli-role-of-calcium-sensitization-and-related-pathways
#18
Young Jae Im, Jung Keun Lee, Sun Hee Lee, Seung-June Oh, Kwanjin Park
This study was carried out to analyze the developmental changes of bladder response to cholinergic stimulation in detail, highlighting calcium sensitization (CS) and its related pathways. Rats were divided into three groups in accordance with reported time of developmental milestones (newborn: day 1-4, youngster: day 5-14 and grown-up: day 15-21). Following cholinergic stimulation (carbachol 5 uM) the contractile response to detrusor were analyzed with respect to three phases (initial phasic, tonic and superimposed phasic contractions)...
April 26, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28445939/epigenetic-therapy-with-inhibitors-of-histone-methylation-suppresses-dna-damage-signaling-and-increases-glioma-cell-radiosensitivity
#19
Ozge Gursoy-Yuzugullu, Chelsea Carman, Rodolfo Bortolozo Serafim, Marios Myronakis, Valeria Valente, Brendan D Price
Radiation therapy is widely used to treat human malignancies, but many tumor types, including gliomas, exhibit significant radioresistance. Radiation therapy creates DNA double-strand breaks (DSBs), and DSB repair is linked to rapid changes in epigenetic modifications, including increased histone methylation. This increased histone methylation recruits DNA repair proteins which can then alter the local chromatin structure and promote repair. Consequently, combining inhibitors of specific histone methyltransferases with radiation therapy may increase tumor radiosensitivity, particularly in tumors with significant therapeutic resistance...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28445914/clinical-significance-of-intraluminal-contrast-enhancement-in-patients-with-spontaneous-cervical-artery-dissection-a%C3%A2-black-blood-mri-study
#20
Eva Coppenrath, Olga Lenz, Nora Sommer, Nina Lummel, Jennifer Linn, Karla Treitl, Fabian Bamberg, Maximilian Reiser, Thomas Pfefferkorn, Tobias Saam
Purpose Recent studies have suggested that intraluminal thrombi show contrast enhancement on carotid black-blood T1w MRI. The aim of this study was to evaluate the significance of intraluminal contrast enhancement (iCE) regarding symptom status in patients with spontaneous cervical artery dissection (sCAD). Methods 33 consecutive patients (19 men) with sCAD received a brain MRI (DIFF, T2w, T2*w, FLAIR) and a multi-sequence 3T-MRI with fat-saturated high-resolution black-blood T1w-sequences pre- and post-contrast, contrast-enhanced MR angiography and TOF images of carotid and vertebral arteries...
April 26, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
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