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https://www.readbyqxmd.com/read/28718993/role-of-fdg-pet-mri-fdg-pet-ct-and-dynamic-susceptibility-contrast-perfusion-mri-in-differentiating-radiation-necrosis-from-tumor-recurrence-in-glioblastomas
#1
Mojgan Hojjati, Chaitra Badve, Vasant Garg, Curtis Tatsuoka, Lisa Rogers, Andrew Sloan, Peter Faulhaber, Pablo R Ros, Leo J Wolansky
BACKGROUND AND PURPOSE: To compare the utility of quantitative PET/MRI, dynamic susceptibility contrast (DSC) perfusion MRI (pMRI), and PET/CT in differentiating radiation necrosis (RN) from tumor recurrence (TR) in patients with treated glioblastoma multiforme (GBM). METHODS: The study included 24 patients with GBM treated with surgery, radiotherapy, and temozolomide who presented with progression on imaging follow-up. All patients underwent PET/MRI and pMRI during a single examination...
July 18, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/28718649/ensemble-and-single-particle-fluorescence-characterization-of-dye-labeled-cellulose-nanocrystals
#2
Tianyang Leng, Zygmunt J Jakubek, Mahyar Mazloumi, Alfred C W Leung, Linda J Johnston
Cellulose nanocrystals (CNCs) have been covalently labeled with both fluorescein and rhodamine and studied by a combination of UV-Vis absorption spectroscopy and ensemble and single molecule fluorescence spectroscopy. For all samples the fluorescence anisotropy and lifetimes were consistent with effects expected for covalently bound dye molecules. Low dye loading levels (~ 0.1 dye/particle) were estimated for the fluorescein-labeled CNC which coupled with the strong pH dependence make this a less suitable fluorophore for most applications...
July 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28718285/strong-blue-emissive-supramolecular-self-assembly-system-based-on-naphthalimide-derivatives-and-its-ability-of-detection-and-removal-of-2-4-6-trinitrophenol
#3
Xinhua Cao, Na Zhao, Haiting Lv, Qianqian Ding, Aiping Gao, Qiangshan Jing, Tao Yi
Two simple and novel gelators (G-P with pyridine and G-B with benzene) with different C-4 substitution groups on naphthalimide derivative have been designed and characterized. Two gelators could form organogels in some solvents or mixed solvents. The self-assembly processes of G-P in mixed solvent of acetonitrile / H2O (1/1, v/v) and G-B in acetonitrile were studied by means of electron microscopy and spectroscopy. The organogel of G-P in mixed solvent of acetonitrile / H2O (1/1, v/v) formed intertwined fiber network, and its emission spectrum had obvious blue shift comparing with that of solution...
July 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28718042/contrast-enhanced-ultrasound-for-focal-liver-lesions-how-accurate-is-it
#4
Richard G Barr
With the recent FDA approval for characterization of focal liver lesions (FLL) in both pediatric and adult patients using Lumason (sulfur hexafluoride microbubbles), increased use of ultrasound contrast for routine clinical use is expected. This agent has been available for many years in Europe and Asia, and a large body of literature is available regarding the sensitivity and specificity of this agent. In addition, a few studies have directly compared CEUS to CECT and CEMRI for the characterization of focal liver lesions...
July 17, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28718041/quality-of-vision-patient-satisfaction-and-long-term-visual-function-after-bilateral-implantation-of-a-low-addition-multifocal-intraocular-lens
#5
Emilio Pedrotti, Rodolfo Mastropasqua, Jacopo Bonetto, Christian Demasi, Francesco Aiello, Carlo Nucci, Cesare Mariotti, Giorgio Marchini
PURPOSE: The aim of the current study was to compare the quality of vision, contrast sensitivity and patient satisfaction with a biaspheric, segmented, rotationally asymmetric IOL (Lentis Comfort LS-313 MF 15-Oculentis GmbH, Berlin, Germany) as opposed to those of a monofocal IOL. METHODS: This prospective single-blind comparative study included two groups of patients affected by bilateral senile cataract who underwent lens extraction and IOL implantation. The first group received a bilateral implantation of a monofocal IOL, and the second group received a bilateral implantation of the Comfort IOL...
July 17, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28717877/temporal-envelope-coding-by-inferior-colliculus-neurons-with-cochlear-implant-stimulation
#6
Kenneth E Hancock, Yoojin Chung, Martin F McKinney, Bertrand Delgutte
Modulations in temporal envelopes are a ubiquitous property of natural sounds and are especially important for hearing with cochlear implants (CIs) because these devices typically discard temporal fine structure information. With few exceptions, neural temporal envelope processing has been studied in both normal hearing (NH) and CI animals using only pure sinusoidal amplitude modulation (SAM) which poorly represents the diversity of envelope shapes contained in natural sounds because it confounds repetition rate and the width of each modulation cycle...
July 17, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/28717193/adhesive-capsulitis-of-the-shoulder-evaluation-with-us-arthrography-using-a-sonographic-contrast-agent
#7
Xueqing Cheng, Zhenqi Zhang, Guo Xuanyan, Tingting Li, Juan Li, Longlin Yin, Man Lu
Adhesive capsulitis (AC) is a painful and disabling disorder, which caused restricted motion and chronic pain of shoulder. Intracavitary contrast-enhanced ultrasound has been recently applied to assess obstructive bile duct diseases, tubal patency, vesicoureteric reflux and so on. The aim of this study was to detect the value of US-arthrography by injecting the contrast agent SonoVue into glenohumeral joint compared with US in diagnosing AC. Utrasound (US) and US-arthrography images of 45 patients with AC were compared with that of 45 control subjects without AC with MRI as a gold standard...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28717136/association-of-plasma-and-urinary-mutant-dna-with-clinical-outcomes-in-muscle-invasive-bladder-cancer
#8
K M Patel, K E van der Vos, C G Smith, F Mouliere, D Tsui, J Morris, D Chandrananda, F Marass, D van den Broek, D E Neal, V J Gnanapragasam, T Forshew, B W van Rhijn, C E Massie, N Rosenfeld, M S van der Heijden
Muscle Invasive Bladder Cancer (MIBC) has a poor prognosis. Whilst patients can achieve a 6% improvement in overall survival with Neo-Adjuvant Chemotherapy (NAC), many do not respond. Body fluid mutant DNA (mutDNA) may allow non-invasive identification of treatment failure. We collected 248 liquid biopsy samples including plasma, cell pellet (UCP) and supernatant (USN) from spun urine, from 17 patients undergoing NAC. We assessed single nucleotide variants and copy number alterations in mutDNA using Tagged-Amplicon- and shallow Whole Genome- Sequencing...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28717130/polymicrobial-infections-in-brain-tissue-from-alzheimer-s-disease-patients
#9
Diana Pisa, Ruth Alonso, Ana M Fernández-Fernández, Alberto Rábano, Luis Carrasco
Several studies have advanced the idea that the etiology of Alzheimer's disease (AD) could be microbial in origin. In the present study, we tested the possibility that polymicrobial infections exist in tissue from the entorhinal cortex/hippocampus region of patients with AD using immunohistochemistry (confocal laser scanning microscopy) and highly sensitive (nested) PCR. We found no evidence for expression of early (ICP0) or late (ICP5) proteins of herpes simplex virus type 1 (HSV-1) in brain sections. A polyclonal antibody against Borrelia detected structures that appeared not related to spirochetes, but rather to fungi...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28716728/cytochrome-p450-3a-selectively-affects-the-pharmacokinetic-interaction-between-erlotinib-and-docetaxel-in-rats
#10
Xuan Qin, Jian Lu, Peili Wang, Peipei Xu, Mingyao Liu, Xin Wang
Erlotinib as a first-line drug is used in non-small cell lung cancer (NSCLC) patients with sensitive EGFR mutations, while resistance to this drug will occur after several years of treatment. Therefore, the microtubule disturber docetaxel is introduced as combined regimen in clinical trials. This report investigated the potentials and mechanisms of drug-drug interaction (DDI) between erlotinib and docetaxel using wild type (WT) and Cyp3a1/2 knockout (KO) rats. The erlotinib O-demethylation and docetaxel hydroxylation reactions in the absence or the presence of another drug were analyzed in vitro via the assay of rat liver microsomes...
July 14, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28716586/comparison-of-three-dimensional-t1-weighted-magnetic-resonance-and-contrast-enhanced-ultrasound-plaque-images-for-severe-stenosis-of-the-cervical-carotid-artery
#11
Yasuyoshi Shimada, Kohki Oikawa, Shunrou Fujiwara, Yasushi Ogasawara, Yuiko Sato, Shinsuke Narumi, Tadayoshi Kato, Kazumasa Oura, Yasuo Terayama, Makoto Sasaki, Kentaro Fujimoto, Jun Yoshida, Kuniaki Ogasawara
BACKGROUND AND PURPOSE: Magnetic resonance (MR) and contrast-enhanced ultrasound assess characteristics and neovascularization, respectively, of the carotid plaque. The purpose of the present study was to clarify how findings of contrast-enhanced ultrasound plaque imaging are related to those of 3-dimensional (3D) fast spin echo (FSE) T1-weighted MR plaque imaging (WI) in severe stenosis (≥70%) of the cervical carotid artery. METHODS: Fifty-three patients underwent 3D FSE T1-WI and contrast-enhanced ultrasound...
July 14, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28716511/an-ensemble-predictive-modeling-framework-for-breast-cancer-classification
#12
Radhakrishnan Nagarajan, Meenakshi Upreti
Molecular changes often precede clinical presentation of diseases and can be useful surrogates with potential to assist in informed clinical decision making. Recent studies have demonstrated the usefulness of modeling approaches such as classification that can predict the clinical outcomes from molecular expression profiles. While useful, a majority of these approaches implicitly use all molecular markers as features in the classification process often resulting in sparse high-dimensional projection of the samples often comparable to that of the sample size...
July 14, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28715805/an-alternative-promoter-in-intron1-of-the-renin-gene-is-regulated-by-glucose-starvation-via-serum-response-factor
#13
Philipp Lutze, Heike Wanka, Inga Bäumgen, Doreen Staar, Bianka Grunow, Jörg Peters
BACKGROUND/AIMS: Renin is known as a secretory glycoprotein that ultimately leads to angiotensin II generation. In this way renin exerts pro-inflammatory effects and promotes cardiac injury. Additional transcripts have been identified encoding for a cytosolic renin isoform that - in contrast to secretory renin - exhibits cardioprotective effects under ischemic conditions. The promoter of these transcripts is unknown. METHODS: Using qRT-PCR and dual-luciferase reporter assay we examined the expression and promotor activity of cytosolic renin as well as the regulation by glucose starvation in H9c2 cardiomyoblasts...
July 17, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28715718/when-speaker-identity-is-unavoidable-neural-processing-of-speaker-identity-cues-in-natural-speech
#14
Alba Tuninetti, Kateřina Chládková, Varghese Peter, Niels O Schiller, Paola Escudero
Speech sound acoustic properties vary largely across speakers and accents. When perceiving speech, adult listeners normally disregard non-linguistic variation caused by speaker or accent differences, in order to comprehend the linguistic message, e.g. to correctly identify a speech sound or a word. Here we tested whether the process of normalizing speaker and accent differences, facilitating the recognition of linguistic information, is found at the level of neural processing, and whether it is modulated by the listeners' native language...
July 14, 2017: Brain and Language
https://www.readbyqxmd.com/read/28715644/detection-and-identification-of-serum-protein-peak-at-6648%C3%A2-m-z-as-a-novel-indicator-in-breast-cancer-based-on-mass-spectrometry
#15
Dongjian Song, Lifang Yue, Yuxiao Zhan, Junjie Zhang, Zechen Yan, Yingzhong Fan, Heying Yang, Da Zhang, Qiuliang Liu, Ziqiang Xia, Pan Qin, Jia Jia, Ming Yue, Jiekai Yu, Shu Zheng, Fuquan Yang, Jiaxiang Wang
Breast cancer (BC) is the second-leading cause of cancer mortality after lung cancer in women owing partly to a lack of specific and sensitive tests for early screening and monitoring. The detection of novel specific BC serum indicators for screening purposes is an essential clinical need. A total of 437 serum specimens from 310 BC patients that were divided into mining and testing sets were collected in this study. In contrast with the conventional BC indicators through receiver operating characteristic, survival and hazard function curves, and multivariate Cox regression analyses, we intended to hunt for stable protein indicators from serum specimens and identify their diagnostic and prognostic potential for BC...
May 2017: Discovery Medicine
https://www.readbyqxmd.com/read/28715367/microfluidic-imaging-flow-cytometry-by-asymmetric-detection-time-stretch-optical-microscopy-atom
#16
Anson H L Tang, Queenie T K Lai, Bob M F Chung, Kelvin C M Lee, Aaron T Y Mok, G K Yip, Anderson H C Shum, Kenneth K Y Wong, Kevin K Tsia
Scaling the number of measurable parameters, which allows for multidimensional data analysis and thus higher-confidence statistical results, has been the main trend in the advanced development of flow cytometry. Notably, adding high-resolution imaging capabilities allows for the complex morphological analysis of cellular/sub-cellular structures. This is not possible with standard flow cytometers. However, it is valuable for advancing our knowledge of cellular functions and can benefit life science research, clinical diagnostics, and environmental monitoring...
June 28, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28715324/electrical-impedance-tomography-tissue-properties-to-image-measures
#17
Andy Adler, Alistair Boyle
Electrical Impedance Tomography (EIT) uses electrical stimulation and measurement at the body surface to image the electrical properties of internal tissues. It has the advantage of non-invasiveness and high temporal resolution but suffers from poor spatial resolution and sensitivity to electrode movement and contact quality. EIT can be useful to applications where there are conductive contrasts between tissues, fluids or gasses, such as imaging of cancerous or ischemic tissue or functional monitoring of breathing, blood flow, gastric motility and neural activity...
July 17, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28714885/differences-in-genetic-background-contribute-to-pseudomonas-exotoxin-a-induced-hepatotoxicity-in-rats
#18
Chien-Chao Chiu, Yu-Chih Wang, Wen-Ching Huang, Yi-Hsun Chen, Shao-Wen Hung, Yen-Te Huang, Hsiao-Li Chuang, Yi-Chih Chang
Pseudomonas aeruginosa exotoxin A (PEA) causes severe hepatotoxicity in experimental animals and is useful in investigations of immune-mediated liver injury. However, strain differences in the sensitivity to PEA-induced hepatotoxicity in rats remains be elucidated. In this study, we determined the severity of PEA-induced hepatotoxicity in six genetically different rat strains. Male LE (Long Evans), Wistar, F344, WKY, BN/SsN and LEW rats were administered a single intravenous injection of PEA (20 μg/kg). Significantly elevated serum ALT and AST levels, massive necrosis and hemorrhage, and numerous TUNEL-positive hepatocytes were observed in BN/SsN rats...
July 15, 2017: Toxins
https://www.readbyqxmd.com/read/28714802/binocular-vision-disorders-and-visual-attention-associations-with-balance-and-mobility-in-older-adults
#19
Mohammed M Althomali, Susan J Leat
Understanding which aspects of vision are related to falls is important. We examine the associations between tests of balance, mobility, fear of falling (FES-1) and aspects of vision in 72 adults aged 70+. Balance and mobility were examined using the One Legged Stance test (OLST), the Sit to Stand test (STST) and the 5 Meter Walking test (5MWT). Visual measures included visual acuity (VA), contrast sensitivity, stereoacuity, binocular vision (BV) measurements, Useful field of View (UFV) and Attended Field of View (AFOV)...
July 17, 2017: Journal of Aging and Physical Activity
https://www.readbyqxmd.com/read/28714696/genetically-encoded-fluorescent-rna-sensor-for-ratiometric-imag-ing-of-microrna-in-living-tumor-cells
#20
Zhan-Ming Ying, Zhan Wu, Bin Tu, Weihong Tan, Jian-Hui Jiang
Light-up RNA aptamers are valuable tools for fluorescence imaging of RNA in living cells and thus for elucidating RNA functions and dynamics. However, no light-up RNA sensor has been reported for imaging of microRNAs (miRs) in mammalian cells. We herein report a novel genetically-encoded RNA sensor for fluorescent imaging of miRs in liv-ing tumor cells using a light-up RNA aptamer which binds to sulforhodamine and separates it from a conjugated contact quencher. Based on the structural switching mechanism characteristic for molecular beacon, we show that the RNA sensor activates high-contrast fluorescence from the sulfor-hodamine-quencher conjugate when its stem-loop respon-sive motif hybridizes with target miR...
July 17, 2017: Journal of the American Chemical Society
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