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https://www.readbyqxmd.com/read/28988432/impact-of-flow-gradient-and-left-ventricular-function-on-outcomes-after-transcatheter-aortic-valve-replacement
#1
Edward T Carreras, Tsuyoshi Kaneko, Fernando Ramirez-Del Val, Marc P Pelletier, Piotr S Sobieszczyk, Deepak L Bhatt, Pinak B Shah
OBJECTIVES: To assess the impact of low flow with and without preserved left ventricular ejection fraction (LVEF) on outcomes after transcatheter aortic valve replacement (TAVR). BACKGROUND: Prior studies have shown that patients with low flow, AVG, and LVEF have worse outcomes after TAVR. It is unclear whether low AVG and LVEF remain prognostic after adjusting for flow, and how the outcomes of patients with low flow with and without preserved LVEF compare after TAVR...
October 8, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28971269/fungation-in-soft-tissue-sarcomas-is-associated-with-poor-survival
#2
Michael Parry, Scott Evans, Subin Sugath, Hazem Wafa, Lee Jeys, Robert Grimer
PURPOSE: Whilst much is known on the multiple variables associated with a poor prognosis in soft tissue sarcomas, little evidence exists on the impact of fungation at the time of presentation. The aim of this study was to assess the impact of fungation on overall and disease free survival in soft tissue sarcomas. METHODS: The study comprised a retrospective review of all patients presenting with a soft tissue sarcoma between 1996 and 2014 managed at a single institution...
December 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28959047/long-non-coding-rna00544-serves-as-a-potential-novel-predictive-and-prognostic-marker-for-hr-%C3%A2-her2-subtype-breast-cancer
#3
Lei Liu, Yayun Chi, Jiajian Chen, Jingyan Xue, Linlin Deng, Naisi Huang, Jianghua Shao, Jiong Wu
Luminal breast cancers (BC) account for majority of breast cancer. Due to its heterogeneity and the development of treatment resistance, luminal BC patients can vary substantially. Long noncoding RNAs (lncRNAs), as we known, is involved in breast cancer progression. Here, we aim to identify the lncRNAs which are involved in the particular type luminal BC progression. By Gene Chips analysis, we found a novel lncRNA00544, which was highly expressed in the metastatic axillary nodes compared with corresponding luminal BC tissues (fold change = 2...
September 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28943908/expression-of-chicken-ovalbumin-upstream-promoter-transcription-factor-ii-and-liver-x-receptor-as-prognostic-indicators-for-human-colorectal-cancer
#4
Seong-Hoon Yun, Min-Gyoung Park, Yu-Mi Kim, Mee-Sook Roh, Joo-In Park
Cholesterol increases the risk of colorectal cancer. Liver X receptor (LXR), retinoid X receptor (RXR)α and sterol regulatory element binding protein (SREBP)-1c are transcriptional regulators of lipid metabolism. Chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) serves an essential role in angiogenesis and development, but its role in cancer is controversial. The expression of COUP-TFII, LXR, RXRα and SREBP-1c in colorectal cancer, as well as their association with clinicopathologic features, was assessed, and their utility as prognostic indicators in colorectal cancer evaluated...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28932385/erratum-to-allergen-immunotherapy-for-ige-mediated-food-allergy-protocol-for-a-systematic-review
#5
Sangeeta Dhami, Ulugbek Nurmatov, Giovanni Battista Pajno, Montserrat Fernandez-Rivas, Antonella Muraro, Graham Roberts, Cezmi Akdis, Montserrat Alvaro-Lozano, Kirsten Beyer, Carsten Bindslev-Jensen, Wesley Burks, George du Toit, Motohiro Ebisawa, Philippe Eigenmann, Edward Knol, Mika Makela, Kari Christine Nadeau, Liam O'Mahony, Nikolaos Papadopoulos, Lars Poulsen, Cansin Sackesen, Hugh Sampson, Alexandra Santos, Ronald van Ree, Frans Timmermans, Aziz Sheikh
[This corrects the article DOI: 10.1186/s13601-016-0113-z.].
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28895130/ancestry-informative-marker-panel-to-estimate-population-stratification-using-genome-wide-human-array
#6
Fernanda B Barbosa, Natalia F Cagnin, Milena Simioni, Allysson A Farias, Fábio R Torres, Miriam C Molck, Tânia K Araujo, Vera L Gil-Da-Silva-Lopes, Eduardo A Donadi, Aguinaldo L Simões
Case-control studies are a powerful strategy to identify candidate genes in complex diseases. In admixed populations, association studies can be affected by population stratification, leading to spurious genetic associations. Ancestry informative markers (AIMs) can be used to minimise this effect. The aim of this work was to select a set of AIMs to estimate population stratification in a Brazilian case-control study performed using a genome-wide array. A total of 345 single nucleotide polymorphism (SNP) AIMs, selected from the Cytoscan HD array and based on previously reported panels, was used to discriminate between European, African, and Amerindian populations...
September 11, 2017: Annals of Human Genetics
https://www.readbyqxmd.com/read/28891597/twelve-month-longitudinal-parasitological-assessment-of-lymphatic-filariasis-positive-individuals-impact-of-a-biannual-treatment-with-ivermectin-and-albendazole
#7
John N Kanamitie, Collins S Ahorlu, Joseph Otchere, Fred Aboagye-Antwi, Bethel Kwansa-Bentum, Daniel A Boakye, Nana-Kwadwo Biritwum, Michael D Wilson, Dziedzom K de Souza
OBJECTIVE: Mass drug administration (MDA) for the control of lymphatic filariasis (LF), in Ghana, started in the year 2000. While this had great success in many implementation units, there remain areas with persistent transmission, after more than 10 years of treatment. A closer examination of the parasite populations could help understand the reasons for persistent infections and formulate appropriate strategies to control LF in these areas of persistent transmission. MATERIALS AND METHODS: In a longitudinal study, we assessed the prevalence of microfilaraemia (mf) in two communities with 12 years of MDA in Ghana...
November 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28867855/an-open-label-randomized-comparative-parallel-group-multicenter-prospective-interventional-clinical-study-to-evaluate-efficacy-and-safety-of-ahpl-aytop-0113-in-comparison-with-framycetin-sulphate-cream-in-acute-wounds
#8
Sanjay U Nipanikar, Kamalakar V Gajare, Vidyadhar G Vaidya, Amol B Kamthe, Sachin A Upasani, Vidyadhar S Kumbhar
OBJECTIVES: The main objective of the present study was to assess efficacy and safety of AHPL/AYTOP/0113 cream, a polyherbal formulation in comparison with Framycetin sulphate cream in acute wounds. METHODOLOGY: It was an open label, randomized, comparative, parallel group and multi-center clinical study. Total 47 subjects were randomly assigned to Group-A (AHPL/AYTOP/0113 cream) and 42 subjects were randomly assigned to Group-B (Framycetin sulphate cream). All the subjects were advised to apply study drug, thrice daily for 21 days or up to complete wound healing (whichever was earlier)...
January 2017: Ancient Science of Life
https://www.readbyqxmd.com/read/28858873/circulating-triglycerides-and-the-association-of-triglycerides-with-dietary-intake-are-altered-by-alpha-2-heremans-schmid-glycoprotein-polymorphisms
#9
Katie N Robinson, Itzel Vazquez-Vidal, Courtney Marques, Flavia Cristina Drumond Andrade, Celia Aradillas-Garcia, Margarita Teran-Garcia
BACKGROUND: Circulating fetuin-A (FetA) inhibits insulin receptor signaling and activates the toll-like receptor 4 proinflammatory cascade; thus, it may contribute to metabolic syndrome. Polymorphisms in alpha-2-Heremans-Schmid glycoprotein (AHSG), the gene which codes FetA, may influence metabolic syndrome progression in higher-risk ethnic groups. We aimed to identify whether individual variation in AHSG influences biomarkers of metabolic disease and obesity in young Mexican adults. METHODS: The participants were Mexican college applicants (18-25 years, n = 641)...
August 31, 2017: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/28759054/the-association-between-retinal-vein-pulsation-pressure-and-optic-disc-haemorrhages-in-glaucoma
#10
Dong An, Philip House, Christopher Barry, Andrew Turpin, Allison M McKendrick, Balwantray C Chauhan, Siobhan Manners, Stuart L Graham, Dao-Yi Yu, William H Morgan
PURPOSE: To explore the potential relationship between optic disc haemorrhage, venous pulsation pressure (VPP), ocular perfusion pressures and visual field change in glaucomatous and glaucoma suspect eyes. MATERIALS AND METHODS: This prospective observational study examined 155 open angle glaucoma or glaucoma suspect eyes from 78 patients over 5 years. Patients were followed with 3 monthly non-mydriatic disc photographs, 6 monthly standard automated perimetry and annual ophthalmodynamometry...
2017: PloS One
https://www.readbyqxmd.com/read/28742824/how-do-rehomed-laboratory-beagles-behave-in-everyday-situations-results-from-an-observational-test-and-a-survey-of-new-owners
#11
Dorothea Döring, Ophelia Nick, Alexander Bauer, Helmut Küchenhoff, Michael H Erhard
When laboratory dogs are rehomed into private households, they experience an extreme change in their life situation. They leave their familiar, limited environment in the research facility and encounter a multitude of animate and inanimate stimuli in their new home. Although literature reports have described the experiences with rehoming as being mostly positive, scientific observations of the dogs in everyday situations have not been done. Hence, we conducted an observational test with 74 laboratory beagles 6 weeks after adoption in their new homes...
2017: PloS One
https://www.readbyqxmd.com/read/28742402/association-of-il-10-regulating-micrornas-in-peripheral-blood-mononuclear-cells-with-the-pathogenesis-of-autoimmune-thyroid-disease
#12
Yukina Takuse, Mikio Watanabe, Naoya Inoue, Ritsuko Ozaki, Hiroshi Ohtsu, Minori Saeki, Yuka Katsumata, Yoh Hidaka, Yoshinori Iwatani
Interleukin (IL)-10 is known to suppress inflammation in autoimmune diseases. IL-10 can be regulated by miRNAs. To elucidate the involvement of miRNAs that regulate IL-10 expression with the pathogenesis of autoimmune thyroid disease (AITD), we examined the expression levels of hsa-miR-27a-3p, hsa-miR-98-5p, hsa-miR-106a-5p, and hsa-miR-223-3p in peripheral blood mononuclear cells (PBMCs) from 43 patients with Graves' disease (GD), 38 patients with Hashimoto's disease (HD), and 21 healthy volunteers. We evaluated the association between the expression levels of four miRNAs and intracellular expression of IL-10 in PBMCs from 11 healthy volunteers...
August 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28729205/antimicrobial-susceptibility-of-clostridium-difficile-isolates-in-israel
#13
Linda Tkhawkho, Orna Nitzan, Nina Pastukh, Diana Brodsky, Karen Jackson, Avi Peretz
OBJECTIVES: An increase of Clostridium difficile isolates with reduced susceptibility to various antimicrobial agents has been observed, including isolates that are non-susceptible to antibiotics that are routinely used for treatment of C. difficile, such as vancomycin and metronidazole. We determined the susceptibility rates of C. difficile isolates from hospitals in northern Israel to various antibiotics including tigecycline, which was not previously reported from Israel. METHODS: A total of 81 stool samples were collected from three hospitals in northern Israel from patients with C...
September 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28600383/validation-of-static-and-dynamic-radiostereometric-analysis-of-the-knee-joint-using-bone-models-from-ct-data
#14
K Stentz-Olesen, E T Nielsen, S De Raedt, P B Jørgensen, O G Sørensen, B L Kaptein, M S Andersen, M Stilling
OBJECTIVES: Static radiostereometric analysis (RSA) using implanted markers is considered the most accurate system for the evaluation of prosthesis migration. By using CT bone models instead of markers, combined with a dynamic RSA system, a non-invasive measurement of joint movement is enabled. This method is more accurate than current 3D skin marker-based tracking systems. The purpose of this study was to evaluate the accuracy of the CT model method for measuring knee joint kinematics in static and dynamic RSA using the marker method as the benchmark...
June 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28534443/cd59-polymorphisms-are-associated-with-gene-expression-and-different-sexual-susceptibility-to-pemphigus-foliaceus
#15
Amanda Salviano-Silva, Maria Luiza Petzl-Erler, Angelica Beate Winter Boldt
Pemphigus foliaceus (PF) is an autoimmune disease, endemic in Brazilian rural areas, characterized by acantholysis and accompanied by complement activation, with generalized or localized distribution of painful epidermal blisters. CD59 is an essential complement regulator, inhibiting formation of the membrane attack complex, and mediating signal transduction and activation of T lymphocytes. CD59 has different transcripts by alternative splicing, of which only two are widely expressed, suggesting the presence of regulatory sites in their noncoding regions...
May 23, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28507886/racial-disparities-in-elderly-patients-receiving-lumbar-spinal-stenosis-surgery
#16
Doniel Drazin, Faris Shweikeh, Carlito Lagman, Beatrice Ugiliweneza, Maxwell Boakye
STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To evaluate for racial disparities in elderly patients having undergone lumbar spinal stenosis surgery. METHODS: The US Medicare Provider Analysis and Review database (records from 2005 to 2011) was used to identify patients over the age of 65 years, diagnosed with lumbar spinal stenosis, and having undergone lumbar laminectomy or fusion surgery. Blacks were compared to Whites in both unmatched and propensity score-matched populations...
April 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28495011/solitary-fibrous-tumour-of-pleura-ct-differentiation-of-benign-and-malignant-types
#17
MULTICENTER STUDY
A Gupta, C A Souza, H S Sekhon, M M Gomes, S S Hare, P P Agarwal, J P Kanne, J M Seely
AIM: To analyse and compare the computed tomography (CT) features of benign and malignant types of histopathologically proven cases of solitary fibrous tumours of pleura (SFTP). MATERIALS AND METHODS: Retrospective analysis of preoperative CT images of 28 cases of histopathologically proven and classified SFTP from three participating institutions was performed. Patient demographics and lesion characteristics including size, borders, presence of a pedicle, extension into the fissure, attenuation, enhancement, pleural effusion, and calcifications were recorded and correlated with the final histopathological diagnosis...
September 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28489782/incidence-and-risk-factors-of-depression-after-diagnosis-of-lung-cancer-a-nationwide-population-based-study
#18
Ming-Szu Hung, I-Chuan Chen, Chuan-Pin Lee, Ru-Jiun Huang, Pau-Chung Chen, Ying-Huang Tsai, Yao-Hsu Yang
This study aimed to explore the incidence and risk factors of depression after lung cancer diagnosis. Using the Taiwan National Health Insurance Research Database (NHIRD), incidences and risk factors of depression in lung cancer and nonlung cancer cohorts were analyzed.From 1998 to 2006, a total of 22,125 patients were included in each matched cohort of lung cancer and nonlung cancer patients from NHIRD. The incidence of depression was higher in the lung cancer cohort than in the nonlung cancer cohort (1545...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28454277/monocyte-derived-dendritic-cells-from-patients-with-cervical-intraepithelial-lesions
#19
Angela Maria Moed Lopes, Márcia Antoniazi Michelin, Eddie Fernando Cândido Murta
Immunotherapy with dendritic cells (DCs) is a great promise for the treatment of neoplasms. However, the obtainment and protocol of differentiation of these cells may depend on extrinsic factors such as the tumor itself. The aim of the present study was to verify the influence of cervical neoplasia on different protocols of differentiation of monocyte-derived DCs resulting in an increased maturation phenotype. A total of 83 women were included in the study. The patients were grouped in low-grade squamous intraepithelial lesion (LSIL) (n=30), high-grade squamous intraepithelial lesion (HSIL) (n=22), cervical cancer (n=10) and healthy patients (n=21) groups...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28345467/mitochondrial-dna-alteration-in-primary-and-metastatic-colorectal-cancer-different-frequency-and-association-with-selected-clinicopathological-and-molecular-markers
#20
Britta Kleist, Thuja Meurer, Micaela Poetsch
This study attempts to determine whether primary tumor tissue could reliably represent metastatic colorectal cancer in therapy-guiding analysis of mitochondrial microsatellite instability. Therefore, we investigated the concordance of microsatellite instability in D310, D514, and D16184 (mitochondrial DNA displacement loop), and its association with selected clinical categories and KRAS/NRAS/BRAF/PIK3CA/TP53 mutation status between primary and metastatic colorectal cancer tissue from 119 patients. Displacement loop microsatellite instability was significantly more frequently seen in lymph node metastases (53...
March 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
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