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https://www.readbyqxmd.com/read/29791368/design-and-analysis-for-a-bend-resistant-and-large-mode-area-photonic-crystal-fiber-with-hybrid-cladding
#1
Yan Qin, Huajun Yang, Ping Jiang, Fengji Gui, Weinan Caiyang, Biao Cao
In this paper, an asymmetric large-mode-area photonic crystal fiber (LMA-PCF) with low bending loss at a smaller bending radius is designed. The finite-element method with a perfectly matched layer boundary is used to analyze the performance of the PCF. To achieve LMA-PCF with low bending loss, the air holes with double lattice constants and different sizes at the core are designed. Numerical results show that this structure can achieve low bending loss and LMA with a smaller bending radius at the wavelength of 1...
May 10, 2018: Applied Optics
https://www.readbyqxmd.com/read/29755754/-chlamydia-pneumoniae-induced-tumour-necrosis-factor-alpha-responses-are-lower-in-children-with-asthma-compared-with-non-asthma
#2
Tamar Anne Smith-Norowitz, Kobkul Chotikanatis, Diana Weaver, Jared Ditkowsky, Yitzchok Meir Norowitz, Margaret R Hammerschlag, Rauno Joks, Stephan Kohlhoff
Introduction: Chlamydia pneumoniae respiratory tract infection has been implicated in the pathogenesis of reactive airway disease and asthma. Innate cytokine responses that are protective of infection with intracellular pathogens may be impaired in patients with asthma. Tumour necrosis factor alpha (TNF-α) is a cytokine related to functions of monocytes and may inhibit C. pneumoniae infection. We investigated TNF-α responses in C. pneumoniae -infected peripheral blood mononuclear cells (PBMCs) in patients with asthma and non-asthma, and whether ciprofloxacin, azithromycin or doxycycline affects TNF-α responses...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29727401/signal-changes-in-the-dentate-nucleus-and-globus-pallidus-on-unenhanced-t1-weighted-magnetic-resonance-images-after-intrathecal-administration-of-macrocyclic-gadolinium-contrast-agent
#3
Kerem Ozturk, Omer Fatih Nas, Esra Soylu, Bahattin Hakyemez
OBJECTIVES: The aim of this study was to evaluate signal changes in the dentate nucleus and globus pallidus (GP) on unenhanced T1-weighted magnetic resonance (MR) images (T1 WI) in a cohort of patients who have received intrathecal macrocyclic ionic gadolinium-based contrast agent (GBCA) gadoterate meglumine. MATERIALS AND METHODS: A group of 20 patients (male/female ratio, 8:12; mean age, 39.5 ± 15.5 years) who had not received intravenous GBCA but had received an intrathecal macrocyclic ionic GBCA (plus baseline and an additional final magnetic resonance imaging [MRI] for reference) from 2012 to 2017 were retrospectively included in this institutional review board-approved study...
April 30, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29664665/genetic-variation-in-nfkb1-gene-influences-liver-enzyme-levels-in-morbidly-obese-women
#4
Guven Yenmis, Tugba Soydas, Hulya Arkan, Ertugrul Tasan, Gonul Kanigur Sultuybek
BACKGROUND: Morbid obesity (MO), characterized by low-grade inflammation, is associated with increased C-reactive protein (CRP). NF-KB is a candidate factor for inflammatory responses in inflammatory diseases such as obesity. The objective of our study was to investigate the relationship between NFKB1 gene variations and the risk of MO in the context of the high/normal level of liver enzymes such as Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT), and alkaline phosphatase (ALP)...
January 1, 2018: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29554875/nitrate-decreases-ruminal-methane-production-with-slight-changes-to-ruminal-methanogen-composition-of-nitrate-adapted-steers
#5
Liping Zhao, Qingxiang Meng, Yan Li, Hao Wu, Yunlong Huo, Xinzhuang Zhang, Zhenming Zhou
BACKGROUND: This study was conducted to examine effects of nitrate on ruminal methane production, methanogen abundance, and composition. Six rumen-fistulated Limousin×Jinnan steers were fed diets supplemented with either 0% (0NR), 1% (1NR), or 2% (2NR) nitrate (dry matter basis) regimens in succession. Rumen fluid was taken after two-week adaptation for evaluation of in vitro methane production, methanogen abundance, and composition measurements. RESULTS: Results showed that nitrate significantly decreased in vitro ruminal methane production at 6 h, 12 h, and 24 h (P < 0...
March 20, 2018: BMC Microbiology
https://www.readbyqxmd.com/read/29551864/risk-assessment-of-osteoporosis-in-pre-and-postmenopausal-periodontally-healthy-and-chronic-periodontitis-women-with-digital-panoramic-radiographs
#6
Rajashri Abhay Kolte, Abhay Pandurang Kolte, Anushree Manohar Potey
Background: Osteoporosis is particularly high in females, the early identification of which remains a challenge. Panoramic radiographs are routinely advised to detect periodontal diseases and can be used to predict low bone mineral density (BMD). Hence, this investigation was aimed to identify the risk of osteoporosis in pre- and postmenopausal periodontally healthy and chronic periodontitis women with digital panoramic radiographs. Materials and Methods: The study population consisted of 120 patients equally divided as Group I - Premenopausal periodontally healthy, Group II - Premenopausal periodontitis, Group III - Postmenopausal periodontally healthy, and Group IV - Postmenopausal periodontitis...
November 2017: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29490023/functional-mitral-stenosis-after-mitral-valve-repair-for-type-ii-dysfunction-determinants-and-impacts-on-long-term-outcome
#7
Naonori Kawamoto, Tomoyuki Fujita, Satsuki Fukushima, Yusuke Shimahara, Yuta Kume, Yorihiko Matsumoto, Kizuku Yamashita, Koko Asakura, Junjiro Kobayashi
OBJECTIVES: This study was performed to analyse the impacts of functional mitral stenosis (MS) following mitral valve (MV) repair on late cardiac function and new onset of atrial fibrillation or survival. METHODS: We retrospectively reviewed 602 patients with mitral regurgitation who underwent MV repair for Type II dysfunction from 2001. Functional MS was diagnosed when the mean transmitral pressure gradient (MTPG) was ≥5 mmHg on postoperative echocardiography...
February 27, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29469611/scoring-analysis-of-the-men-s-2014-2015-and-2016-world-championship-tour-of-surfing-the-importance-of-aerial-manoeuvres-in-competitive-surfing
#8
Brendon Ferrier, Jeremy Sheppard, Oliver R L Farley, Josh L Secomb, Joanna Parsonage, Robert U Newton, Sophia Nimphius
The aim of this study was to investigate the impact of aerial manoeuvres on scoring in professional surfing. 23,631 waves were analysed for the number and types of aerial manoeuvres performed from the 2014, 2015 and 2016 Men's World Championship Tour. Additionally, the awarded score, timing and order of the aerial was also analysed. Descriptive statistics and Two Way ANOVA's were performed with Sidak Multiple Comparisons Post Hoc analysis. Results were a significantly higher score being awarded (P ≤ 0.0001) when including an aerial in competition across all three seasons...
February 22, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29456079/phase-iv-randomized-clinical-study-peginterferon-alfa-2a-with-adefovir-or-entecavir-pre-therapy-for-hbeag-positive-chronic-hepatitis-b
#9
Chao-Wei Hsu, Wei-Wen Su, Chuan-Mo Lee, Cheng-Yuan Peng, Wan-Long Chuang, Jia-Horng Kao, Heng-Cheng Chu, Yi-Hsiang Huang, Rong-Nan Chien, Yun-Fan Liaw
BACKGROUND: Efficacy of sequential therapy with nucleos(t)ide analogues and interferons versus monotherapy in patients with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) remains unexplored. We aimed to assess efficacy and safety of sequential therapy with adefovir (ADV) or entecavir (ETV) followed by peginterferon (PEG-IFN) alfa-2a in Taiwanese patients with HBeAg-positive. METHODS: This randomized, placebo-controlled, double-blind trial was conducted at nine sites in Taiwan from April 2010 to October 2013...
February 16, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29416666/recombinant-methioninase-rmetase-is-an-effective-therapeutic-for-braf-v600e-negative-as-well-as-positive-melanoma-in-patient-derived-orthotopic-xenograft-pdox-mouse-models
#10
Kei Kawaguchi, Kentaro Igarashi, Shukuan Li, Qinghong Han, Yuying Tan, Kentaro Miyake, Tasuku Kiyuna, Masuyo Miyake, Takashi Murakami, Bartosz Chmielowski, Scott D Nelson, Tara A Russell, Sarah M Dry, Yunfeng Li, Michiaki Unno, Fritz C Eilber, Robert M Hoffman
Melanoma is a recalcitrant disease. Melanoma patients with the BRAF-V600E mutation have been treated with the drug vemurafenib (VEM) which targets this mutation. However, we previously showed that VEM is not very effective against a BRAF-V600E melanoma mutant in a patient-derived orthotopic xenograft (PDOX) model. In contrast, we demonstrated that recombinant methioninase (rMETase) which targets the general metabolic defect in cancer of methionine dependence, was effective against the BRAF-V600E mutant melanoma PDOX model...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29373310/-obstetrical-follow-up-and-perinatal-prognosis-in-drug-addict-pregnant-women
#11
B Fanjeaux, A Braconnier, I Clerc-Urmès, O Morel, E Gauchotte
OBJECTIVE: To identify the factors associated with a good obstetric follow-up and a good perinatal prognosis, in order to adapt the management of pregnant women with addiction to opiates. METHODS: A retrospective study was carried out in our maternity between January 2012 and December 2014, including 104 women who were addicted to opiates, whether or not they were substituted, with or without associated consumptions, regardless of the term of delivery beyond 22 weeks of amenorrhea...
February 2018: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29301583/which-factor-is-the-most-effective-one-in-metabolic-sydrome-on-the-outcomes-after-coronary-artery-bypass-graft-surgery-a-cohort-study-of-5-years
#12
Lijuan Wang, Xiangyang Qian, Mingya Wang, Xinran Tang, Hushan Ao
BACKGROUND: Metabolic Syndrome and diabetes mellitus are risk factors for cardiovascular disease. However, the effects of Metabolic Syndrome with or without diabetes on perioperative and long-term morbidity and mortality after Coronary Artery Bypass Graft remain unclear. METHODS: An retrospective study was performed on 1166 patients who received isolated primary Coronary Artery Bypass Graft in Fuwai hospital. They were divided into three groups: control, Metabolic Syndrome of three factors together with diabetes and Metabolic Syndrome of three factors without diabetes (n = 868, 76 and 222 respectively)...
January 4, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29296178/prognostic-relevance-of-ttf-1-expression-in-stage-i-adenocarcinoma
#13
Chao Zhou, Jikai Zhao, Jinchen Shao, Wentao Li
Tyroid transcription factor-1 (TTF-1) motivates the differentiation and development of bronchioloalveolar cells. The association of TTF-1 expression with prognosis in stage I adenocarcinoma is unclear. This study enrolled patients with resected stage I pulmonary adenocarcinoma who had TTF-1 immunostaining. All the corresponding clinicopathologic data including sex, age, smoking history, pathologic T stage, pathologic disease stage, surgical procedure, subtypes, follow-up records and adjuvant chemotherapy were investigated...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29295705/chemokine-ccl27-is-a-novel-plasma-biomarker-for-identification-the-nasopharyngeal-carcinoma-patients-from-the-epstein-barr-virus-capsid-antigen-specific-iga-seropositive-population
#14
Min-Jie Mao, Ning Xue, Xue-Ping Wang, Pei-Dong Chi, Yi-Jun Liu, Qi Huang, Shu-Qin Dai, Wan-Li Liu
BACKGROUND: To investigate the predictive value of chemokine CCL27 for identifying early stage nasopharyngeal carcinoma (NPC) patients within a population seropositive for Epstein-Barr virus (EBV) capsid antigen-specific IgA (VCA-IgA). METHODS: CCL27 in plasma samples from 104 NPC patients, 112 VCA-IgA-positive healthy donors, and 140 VCA-IgA-negative normal subjects was measured by ELISA. Expression of CCL27 in nasopharyngeal tissue from 20 VCA-IgA-positive healthy donors and 20 NPC patients was examined by immunohistochemical staining...
January 2, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29290897/dose-related-effects-of-dexmedetomidine-on-immunomodulation-and-mortality-to-septic-shock-in-rats
#15
Yan Ma, Xiang-You Yu, Yi Wang
BACKGROUND: Dexmedetomidine has already been used in septic patients as a new sedative agent, few studies have examined its effects on immunomodulation. Therefore, the authors have designed a controlled experimental study to characterize the immunomodulation effects of dexmedetomidine in the cecal ligation and puncture (CLP) model in rats. METHODS: After CLP, 48 Wistar rats were randomly allocated into four groups: (1) CLP group; (2) small-dose treatment group (2...
2018: World Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29227056/the-value-of-supplementary-anatomy-workshops-for-improving-undergraduate-performance
#16
J Scott, G Louw, D Kahn
BACKGROUND: With many anatomy courses within the medical curriculum suffering reductions in lecture and dissection time, supplementary programs in anatomy have shown to improve performance of medical students. This study was conducted to evaluate the efficacy of anatomy workshops on undergraduate anatomy grade performance. METHOD: From 2012 to 2014, mean anatomy and physiology scores of medical students who attended anatomy workshops were compared to those who did not attend...
November 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/29163127/post-stroke-fatigue-and-depressive-symptoms-are-differentially-related-to-mobility-and-cognitive-performance
#17
Bradley J MacIntosh, Jodi D Edwards, Mani Kang, Hugo Cogo-Moreira, Joyce L Chen, George Mochizuki, Nathan Herrmann, Walter Swardfager
Background: Fatigue and depressive symptoms are common and often inter-related stroke sequelae. This study investigates how they are related, directly or indirectly, to mobility and cognitive outcomes within 6 months of stroke. Methods: Participants were recruited from 4 stroke centers in Ontario, Canada. Post-stroke fatigue was assessed using the Fatigue Assessment Scale (FAS). Depressive symptoms were screened using the Center for Epidemiological Studies Scale for Depression (CES-D). Factor analyses were used to construct scores from mobility (distance traveled during a 2-min walk test, Chedoke-McMaster Stroke Assessment leg score, and Berg Balance Scale total score) and cognitive (Montreal Cognitive Assessment, Trail-Making Tests A and B, and five-word free recall) tests...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28988432/impact-of-flow-gradient-and-left-ventricular-function-on-outcomes-after-transcatheter-aortic-valve-replacement
#18
Edward T Carreras, Tsuyoshi Kaneko, Fernando Ramirez-Del Val, Marc P Pelletier, Piotr S Sobieszczyk, Deepak L Bhatt, Pinak B Shah
OBJECTIVES: To assess the impact of low flow with and without preserved left ventricular ejection fraction (LVEF) on outcomes after transcatheter aortic valve replacement (TAVR). BACKGROUND: Prior studies have shown that patients with low flow, AVG, and LVEF have worse outcomes after TAVR. It is unclear whether low AVG and LVEF remain prognostic after adjusting for flow, and how the outcomes of patients with low flow with and without preserved LVEF compare after TAVR...
March 1, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28971269/fungation-in-soft-tissue-sarcomas-is-associated-with-poor-survival
#19
Michael Parry, Scott Evans, Subin Sugath, Hazem Wafa, Lee Jeys, Robert Grimer
PURPOSE: Whilst much is known on the multiple variables associated with a poor prognosis in soft tissue sarcomas, little evidence exists on the impact of fungation at the time of presentation. The aim of this study was to assess the impact of fungation on overall and disease free survival in soft tissue sarcomas. METHODS: The study comprised a retrospective review of all patients presenting with a soft tissue sarcoma between 1996 and 2014 managed at a single institution...
December 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28959047/long-non-coding-rna00544-serves-as-a-potential-novel-predictive-and-prognostic-marker-for-hr-%C3%A2-her2-subtype-breast-cancer
#20
Lei Liu, Yayun Chi, Jiajian Chen, Jingyan Xue, Linlin Deng, Naisi Huang, Jianghua Shao, Jiong Wu
Luminal breast cancers (BC) account for majority of breast cancer. Due to its heterogeneity and the development of treatment resistance, luminal BC patients can vary substantially. Long noncoding RNAs (lncRNAs), as we known, is involved in breast cancer progression. Here, we aim to identify the lncRNAs which are involved in the particular type luminal BC progression. By Gene Chips analysis, we found a novel lncRNA00544, which was highly expressed in the metastatic axillary nodes compared with corresponding luminal BC tissues (fold change = 2...
September 28, 2017: Scientific Reports
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