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"Protective Medicine"

Chang-Lin Lai, Hong Wu, Gen-Jin Ni
Guangdong Pericarpium Citri Reticulatae is the traditional Chinese herbal medicine, and has been used for a long history. The authentic drug name Guangdong Pericarpium Citri Reticulatae was rare in the Song Dynasty literature, but from the textual research of the authors, it was otherwise nicknamed as "real orange peel" or "real tangerine peel". These two names were ahead of the origin of Guangdong Pericarpium Citri Reticulatae. Some scholars believe that the name Guangdong Pericarpium Citri Reticulatae was from the Ming Dynasty Dr...
February 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Qianying Chen, Hongzhu Chen, Wenjie Wang, Jiali Liu, Wenyue Liu, Ping Ni, Guowei Sang, Guangji Wang, Fang Zhou, Jingwei Zhang
Entecavir (ETV) is a superior nucleoside analogue used to treat hepatitis B virus (HBV) infection. Although its advantages over other agents include low viral resistance and the elicitation of a sharp decrease in HBV DNA, adverse effects such as hepatic steatosis, hepatic damage and lactic acidosis have also been reported. Glycyrrhizin has long been used as hepato-protective medicine. The clinical combination of ETV plus glycyrrhizin in China displays better therapeutic effects and lower rates of liver damage...
June 13, 2017: European Journal of Pharmaceutical Sciences
Ailing Ma, Yongya Yang, Qiuyang Wang, Yin Wang, Jing Wen, Yanli Zhang
Oxymatrine (OMT), a monosomic alkaloid extracted from the Chinese herb, Sophora flavescens Ait, has long been used as a traditional Chinese medicine for the treatment of inflammatory diseases. The aim of the present study was to investigate the potential anti‑inflammatory effect of OMT, and its modulation on imbalance between regulatory T (Treg) cells and T helper (Th) 17 cells in rats with collagen‑induced arthritis (CIA). Sprague‑Dawley rats were immunized with type II collagen and following a second collagen immunization, the rats were treated with OMT or dexamethasone (DXM) intraperitoneally once a day for 43 days...
June 2017: Molecular Medicine Reports
J H Qu, Z Q Wang, Y Zhang, X G Sun
Objective: To study the clinical manifestations, diagnosis and treatment of corneal epithelial dysfunction after cataract extraction. Methods: Fifteen cases diagnosed as corneal epithelial dysfunction after cataract extraction between November 2014 and September 2016 were retrospectively analyzed, mainly including clinical manifestations, characteristics of morphological changes imaged by in vivo laser confocal microscopy, management and therapeutic effects. Results: There were 6 (40%) males and 9 (60%) females with an average age of 66±7 years (59 to 86 years)...
March 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Jim Kling
No abstract text is available yet for this article.
June 1, 2016: Nature Plants
Jim Kling
No abstract text is available yet for this article.
May 4, 2016: Nature Plants
Amy Kapczynski, Aaron S Kesselheim
The high cost of patent-protected brand-name drugs can strain budgets and curb the widespread use of new medicines. An example is the case of direct-acting antiviral drugs for the treatment of hepatitis C. While prices for these drugs have come down in recent months, they still create barriers to treatment. Additionally, prescribing restrictions imposed by insurers put patients at increased risk of medical complications and contribute to transmission of the hepatitis C virus. We propose that the federal government invoke its power under an existing "government patent use" law to reduce excessive prices for important patent-protected medicines...
May 1, 2016: Health Affairs
Xiao-bing Ma, Shi-hu Zhang, Long-long Jiang, Min Dai, Yan-fei Jiang, Bi-yu Jiang
OBJECTIVE: To study the medicinal plant resources and their diversity in Kangle County, Gansu Province, and to provide scientific basis on utilization and protection of the medicinal plant resources of the county. METHODS: By field survey, sample collection, taxonomic identification and data verification methods. RESULTS: There were 258 species, 65 families in existing medicinal plants, of which 43 species, 39 genera and 24 families were national protection medicinal plants...
February 2015: Zhong Yao Cai, Zhongyaocai, Journal of Chinese Medicinal Materials
D T Goodhead
Microdosimetry is the study and application of the microscopic features and stochastics of ionising radiations that cannot be described by the average macroscopic quantity absorbed dose. Microdosimetry is intimately related to radiation quality, but it also encompasses the inhomogeneities of interactions and energy depositions within a single radiation type. A variety of past and current approaches will be summarised and some examples given of implications to radiation protection and medicine, as well as to basic mechanistic studies of radiation effects...
September 2015: Radiation Protection Dosimetry
Rajesh Krithika, Ramtej J Verma, Pranav S Shrivastav, Lonchin Suguna
BACKGROUND: Phyllanthus amarus, a traditional herbal liver-protecting medicine, is known to contain an active ingredient phyllanthin. Many research studies and clinical trials performed in the past using this plant have given contentious results which clearly accentuates the need for the standardization of the extracts. AIM: In this study, P. amarus extract was standardized for phyllanthin content by high performance thin layer chromatography (HPTLC) and high performance liquid chromatography (HPLC) analysis...
September 2011: Journal of Clinical and Experimental Hepatology
Ramin Asgary
During armed conflicts over the past several years, attacks on humanitarian workers and patients have increased, including the most recent overt killing of patients in their hospital beds in South Sudan and Central African Republic, and bombardments of hospitals in Iraq, Syria, and other countries. Direct attacks on patients inside hospitals, as well as social structural dynamics that undermine patient safety and security, are met with apparent indifference by international and medical communities. How can the medical profession remain silent and stand by while these factors render its core mission futile? In this article, I aim to shed light on this issue, and its implications for the future of the neutral and impartial provision of medical care; provide an analysis of underlying and contributing factors; discuss current international strategies; reflect on the responsibility of health providers; explore ways to strengthen our roles as physician advocates; and call for the medical profession to do more to protect medicine's core values...
April 2015: American Journal of Tropical Medicine and Hygiene
Na He, Yingfeng Ye
INTRODUCTION: Compared with western countries, China started to provide free medicine for AIDS patients years later, which leads to the late emergence of problems on health service demands of AIDS long-surviving patients with non-AIDS-related diseases. Government hasn't laid enough stress on it. MATERIALS AND METHODS: The interviews and questionnaire surveys are conducted and analyzed to get information. The interviewees include 81 AIDS long-surviving patients in three villages and several hospitals in Shangcai, Zhumadian, and 18 AIDS-related decision makers and health service providers...
2014: Journal of the International AIDS Society
Beata Zabrzewska, Anna Chyła, Anna Bogdan
Preservatives are chemical substances whose role is to protect medicinal products against harmful changes caused by microorganisms. They are added to sterile medicinal products, such as eye drops and multidose solutions for injections, as well as to non-sterile products, such as water oral solutions, creams, gels, suppositories and capsules with liquid content. The most commonly used preservatives include: benzyl alcohol, butyl, ethyl, methyl and propyl p-hydroxybenzoates and their sodium salts. In medicinal products benzyl alcohol slowly oxidizes to benzaldehyde and benzoic acid while esters of p-hydroxybenzoic acid hydrolyze to p-hydroxybenzoic acid...
July 2014: Acta Poloniae Pharmaceutica
Felicity Astin, Judith Horrocks, S Jose Closs
BACKGROUND: Coronary heart disease is an incurable condition. The only approach known to slow its progression is healthy lifestyle change and concordance with cardio-protective medicines. Few people fully succeed in these daily activities so potential health improvements are not fully realised. Little is known about peoples' experiences of managing lifestyle change. The aim of this study was to synthesise qualitative research to explain how participants make lifestyle change after a cardiac event and explore this within the wider illness experience...
August 5, 2014: BMC Cardiovascular Disorders
Qin-she Liu, Hai-fang Wang, An-ke Sun, Xue-ping Huo, Jin-lian Liu, Shu-hui Ma, Ning Peng, Jun Hu
BACKGROUND: Both total astragalus saponins (AST) and it's main component astragaloside IV (ASIV) have been used in China as cardiovascular protective medicines. However, the anti-inflammatory activities that are beneficial for cardiovascular health have never been compared directly and the molecular mechanisms remain unresolved. This study was conducted to compare the inhibitory effects of these drugs on TNFα-induced cell responses, related signaling pathways, and the underlying mechanisms in mouse arterial endothelial cells...
2014: PloS One
Nargis Jamila, Melati Khairuddean, Nik Soriani Yaacob, Nik Nur Syazni Nik Mohamed Kamal, Hasnah Osman, Sadiq Noor Khan, Naeem Khan
Garcinia hombroniana (seashore mangosteen) in Malaysia is used to treat itching and as a protective medicine after child birth. This study was aimed to investigate the bioactive chemical constituents of the bark of G. hombroniana. Ethyl acetate and dichloromethane extracts of G. hombroniana yielded two new (1, 9) and thirteen known compounds which were characterized by the spectral techniques of NMR, UV, IR and EI/ESI-MS, and identified as; 2,3',4,5'-tetrahydroxy-6-methoxybenzophenone(1), 2,3',4,4'-tetrahydroxy-6-methoxybenzophenone (2), 2,3',4,6-tetrahydroxybenzophenone (3), 1,3,6,7-tetrahydroxyxanthone (4), 3,3',4',5,7-pentahydroxyflavone (5),3,3',5,5',7-pentahydroxyflavanone (6), 3,3',4',5,5',7-hexahydroxyflavone (7), 4',5,7-trihydroxyflavanone-7-rutinoside (8), 18(13→17)-abeo-3β-acetoxy-9α,13β-lanost-24E-en-26-oic acid (9), garcihombronane B (10), garcihombronane D (11), friedelan-3-one (12), lupeol (13), stigmasterol (14) and stigmasterol glucoside (15)...
June 2014: Bioorganic Chemistry
Ran-Ran Zhao, Xiao-Chen Xu, Fei Xu, Wei-Li Zhang, Wen-Lin Zhang, Liang-Min Liu, Wei-Ping Wang
Cognitive impairment, the most common and severe comorbidity of epilepsy, greatly diminishes the quality of life. However, current therapeutic interventions for epilepsy can also cause untoward cognitive effects. Thus, there is an urgent need for new kinds of agents targeting both seizures and cognition deficits. Oxidative stress is considered to play an important role in epileptogenesis and cognitive deficits, and antioxidants have a putative antiepileptic potential. Metformin, the most commonly prescribed antidiabetic oral drug, has antioxidant properties...
June 13, 2014: Biochemical and Biophysical Research Communications
Nargis Jamila, Melati Khairuddean, Sadiq Noor Khan, Naeem Khan
The genus Garcinia is reported to possess antimicrobial, anti-inflammatory, anticancer, hepatoprotective and anti-HIV activities. Garcinia hombroniana in Malaysia is used to treat itching and as a protective medicine after child birth. This study was aimed to isolate the chemical constituents from the bark of G. hombroniana and explore their possible pharmacological potential. Ethyl acetate extract afforded one new (1) and six (2-7) known 3 → 8 rotameric biflavonoids. Their structures were elucidated by UV, IR and NMR (1D and 2D) spectroscopy together with electron ionization/ESI mass spectrometric techniques and were identified as (2R, 3S) volkensiflavone-7-O-rhamnopyranoside (1), volkensiflavone (2), 4″-O-methyl-volkensiflavone (3), volkensiflavone-7-O-glucopyranoside (4), morelloflavone (5), 3″-O-methyl-morelloflavone (6) and morelloflavone-7-O-glucopyranoside (7)...
July 2014: Magnetic Resonance in Chemistry: MRC
William F Morgan, William J Bair
Both natural and man-made sources of ionizing radiation contribute to human exposure and consequently pose a possible risk to human health. Much of this is unavoidable, e.g., natural background radiation, but as the use of radiation increases, so does the potential health risk and the public's concerns. This perspective reflects the authors' view of current issues in low dose radiation biology research, highlights some of the controversies therein, and suggests areas of future research to address both issues in low dose radiation research and the controversies...
May 2013: Radiation Research
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