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JOURNAL ARTICLE
Susan K Potterveld, Aysha Mubeen, William J Anderson, Michael R Clay, Melanie Bourgeau, Gregory W Charville, Ankur R Sangoi
AIMS: Classification of renal neoplasms on small tissue biopsies is in increasing demand, and maintaining broad differential diagnostic considerations in this setting is necessary. When evaluating a renal or perirenal tumour biopsy with sarcomatoid morphology, together with sarcomatoid renal cell carcinoma and sarcomatoid urothelial carcinoma as top diagnostic considerations, it is vital to additionally consider the possibility of well-differentiated and de-differentiated liposarcoma...
April 22, 2024: Histopathology
#2
JOURNAL ARTICLE
Federica Mazzoleni, Davide Perri, Andrea Pacchetti, Elena Morini, Lorenzo Berti, Umberto Besana, Eliodoro Faiella, Lorenzo Moramarco, Domiziana Santucci, Davide Fior, Giorgio Bozzini
OBJECTIVES: To compare surgical and functional outcomes between off-clamp robot-assisted partial nephrectomy with indocyanine-green tumour marking through preliminary superselective embolization and on-clamp robot-assisted partial nephrectomy with intraoperative ultrasound identification of the renal mass. MATERIAL AND METHODS: One hundred and forty patients with a single renal mass underwent indocyanine-green fluorescence-guided off-clamp robot-assisted partial nephrectomy with preoperative superselective embolization (Group A, 70 patients) versus intraoperative ultrasound-guided on-clamp robot-assisted partial nephrectomy without embolization (Group B, 70 patients)...
April 2024: BJUI compass
#3
REVIEW
Kunal K Sindhu, Zachary Dovey, Marcher Thompson, Anthony D Nehlsen, Karin A Skalina, Beata Malachowska, Shaakir Hasan, Chandan Guha, Justin Tang, Lucas Resende Salgado
BACKGROUND: Racial disparities in oncological outcomes resulting from differences in social determinants of health (SDOH) and tumour biology are well described in prostate cancer (PCa) but similar inequities exist in bladder (BCa) and renal cancers (RCCs). Precision medicine (PM) aims to provide personalized treatment based on individual patient characteristics and has the potential to reduce these inequities in GU cancers. OBJECTIVE: This article aims to review the current evidence outlining racial disparities in GU cancers and explore studies demonstrating improved oncological outcomes when PM is applied to racially diverse patient populations...
April 2024: BJUI compass
#4
JOURNAL ARTICLE
Mahesh Menon, Subhashini Perumal, Raza Ahmad, Priya Das, Shiv Pratap Singh Rana, Asif Sardar
OBJECTIVES: Our research aimed to examine the characteristics of palliative oncology patients hospitalised through an emergency to look for the symptom profile, characteristics of dyselectrolytemia and blood investigations, and possible associations with mortality. MATERIALS AND METHODS: After institutional review board approval, a retrospective, observational study of patients hospitalised in our tertiary care specialty oncology hospital was undertaken. Records of hospitalised cancer patients admitted from the emergency department under palliative care from January 2019 to October 2021 were examined...
2024: Indian Journal of Palliative Care
#5
REVIEW
Zhiqiang Zeng, Si Ge, Yunxiang Li, Lijian Gan, Chunyang Meng, Kangsen Li, Zuoping Wang, Lei Zheng
OBJECTIVE: Which is superior, partial nephrectomy (PN) or radical nephrectomy (RN), for the treatment of complex renal tumours (RENAL or score ≥ 7)? METHODS: This systematic review and meta-analysis was conducted in accordance with the PRISMA statement. A systematic search of the literature published before November 2023 was conducted using Pubmed, Embase, Cochran, and Web of Science libraries. We included studies comparing perioperative and oncologic outcomes of partial nephrectomy and radical nephrectomy for complex renal tumors...
April 17, 2024: Annals of Surgical Oncology
#6
JOURNAL ARTICLE
Maryam Soleimani, Marisa Thi, Sajjad Janfaza, Gizem Ozcan, Sylwia Mazurek, Guliz Ozgun, Corinne Maurice-Dror, Bernhard Eigl, Kim Chi, Christian Kollmannsberger, Lucia Nappi
Predictive biomarkers of response to immune checkpoint-based therapies (ICI) remain a critically unmet need in the management of advanced renal cell carcinoma (RCC). The complex interplay of the tumour microenvironment (TME) and the circulating immune response has proven to be challenging to decipher. MicroRNAs have gained increasing attention for their role in post-transcriptional gene expression regulation, particularly because they can have immunomodulatory properties. We evaluated the presence of immune-specific extracellular vesicle (EV) microRNAs in the plasma of patients with metastatic RCC (mRCC) prior to initiation of ICI...
April 13, 2024: Scientific Reports
#7
JOURNAL ARTICLE
Zhiyong Jiang, Wenbo Sun, Dan Xu, Hao Mei, Jianmin Yuan, Xiaopeng Song, Chao Ma, Haibo Xu
PURPOSE: This study investigated and compared the effects of Gd enhancement on brain tumours with a half-dose of contrast medium at 5.0 T and with a full dose at 3.0 T. METHODS: Twelve subjects diagnosed with brain tumours were included in this study and underwent MRI after contrast agent injection at 3.0 T (full dose) or 5.0 T (half dose) with a 3D T1-weighted gradient echo sequence. The postcontrast images were compared by two independent neuroradiologists in terms of the signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR) and subjective image quality score on a ten-point Likert scale...
April 13, 2024: BMC Medical Imaging
#8
JOURNAL ARTICLE
Vaibhavi Joshi, Kate Beecher, Malcolm Lim, Andrew Stacey, Yufan Feng, Parmjit S Jat, Pascal H G Duijf, Peter T Simpson, Sunil R Lakhani, Amy E McCart Reed
Brain metastasis is a significant challenge for some breast cancer patients, marked by its aggressive nature, limited treatment options, and poor clinical outcomes. Immunotherapies have emerged as a promising avenue for brain metastasis treatment. B7-H3 (CD276) is an immune checkpoint molecule involved in T cell suppression, which is associated with poor survival in cancer patients. Given the increasing number of clinical trials using B7-H3 targeting CAR T cell therapies, we examined B7-H3 expression across breast cancer subtypes and in breast cancer brain metastases to assess its potential as an interventional target...
April 3, 2024: International Journal of Molecular Sciences
#9
JOURNAL ARTICLE
Mike B Barnkob, Yale S Michaels, Violaine André, Philip S Macklin, Uzi Gileadi, Salvatore Valvo, Margarida Rei, Corinna Kulicke, Ji-Li Chen, Vitul Jain, Victoria K Woodcock, Huw Colin-York, Andreas V Hadjinicolaou, Youxin Kong, Viveka Mayya, Julie M Mazet, Gracie-Jennah Mead, Joshua A Bull, Pramila Rijal, Christopher W Pugh, Alain R Townsend, Audrey Gérard, Lars R Olsen, Marco Fritzsche, Tudor A Fulga, Michael L Dustin, E Yvonne Jones, Vincenzo Cerundolo
Semaphorin-3A (SEMA3A) functions as a chemorepulsive signal during development and can affect T cells by altering their filamentous actin (F-actin) cytoskeleton. The exact extent of these effects on tumour-specific T cells are not completely understood. Here we demonstrate that Neuropilin-1 (NRP1) and Plexin-A1 and Plexin-A4 are upregulated on stimulated CD8+ T cells, allowing tumour-derived SEMA3A to inhibit T cell migration and assembly of the immunological synapse. Deletion of NRP1 in both CD4+ and CD8+ T cells enhance CD8+ T-cell infiltration into tumours and restricted tumour growth in animal models...
April 12, 2024: Nature Communications
#10
REVIEW
Gordan M Vujanić, William Mifsud
Anaplasia in Wilms tumor is recognized as the most important prognostically unfavorable histological feature. It is subtyped as focal anaplastic Wilms tumor (FAWT) and diffuse anaplastic Wilms tumor (DAWT). Outcomes of patients with DAWT remain poor in patients with stage III and IV tumors. Important issues relevant to anaplasia in Wilms tumor, including prevalence, treatment, outcomes, biomarkers, anaplasia, and chemotherapy, and the concept of tumor aggressiveness, are reviewed and discussed here. We also consider the differences in clinical approaches to anaplasia in Wilms tumor between the two major renal tumor clinical research groups: the International Society of Paediatric Oncology (SIOP) Renal Tumour Study Group and the Children's Oncology Group (COG) Renal Tumor Group...
April 11, 2024: Pediatric Blood & Cancer
#11
JOURNAL ARTICLE
Sripriya Ramalingam, Parthasarathy Srinivasan
Catecholamine surge and haemodynamic derangements are normally expected during the surgery for pheochromocytoma and benign functioning adrenal tumours. This male patient in his 50s underwent radical nephrectomy for renal cell carcinoma. The patient had no comorbidities. Three hours into the surgery, during electrocauterisation of the upper pole of the kidney, the patient's blood pressure unexpectedly spiked to 180/110 mm Hg, which was immediately followed by a decrease in heart rate to 35-38 beats/min...
April 10, 2024: BMJ Case Reports
#12
REVIEW
Andrey Soares, Fernando Sabino Marques Monteiro, Karine Martins da Trindade, Adriano Gonçalves E Silva, Ana Paula Garcia Cardoso, André Deeke Sasse, André P Fay, André Paternò Castello Dias Carneiro, Antonio Machado Alencar Junior, Augusto César de Andrade Mota, Bruno Santucci, Daniel da Motta Girardi, Daniel Herchenhorn, Daniel Vilarim Araújo, Denis Leonardo Jardim, Diogo Assed Bastos, Diogo Rodrigues Rosa, Fabio A Schutz, Fábio Roberto Kater, Felipe da Silva Marinho, Fernando Cotait Maluf, Fernando Nunes Galvão de Oliveira, Fernando Vidigal, Igor Alexandre Protzner Morbeck, Jose Augusto Rinck Júnior, Leonardo Atem G A Costa, Manuel Caitano Dias Ferreira Maia, Manuela Zereu, Marcelo Roberto Pereira Freitas, Mariane Sousa Fontes Dias, Milena Shizue Tariki, Pamela Muniz, Patrícia Medeiros Milhomem Beato, Paulo Sérgio Moraes Lages, Pedro Isaacsson Velho, Ricardo Saraiva de Carvalho, Rodrigo Coutinho Mariano, Sandro Roberto de Araújo Cavallero, Thiago Martins Oliveira, Vinicius Carrera Souza, Oren Smaletz, Stênio de Cássio Zequi
PURPOSE: Renal cell carcinoma is an aggressive disease with a high mortality rate. Management has drastically changed with the new era of immunotherapy, and novel strategies are being developed; however, identifying systemic treatments is still challenging. This paper presents an update of the expert panel consensus from the Latin American Cooperative Oncology Group and the Latin American Renal Cancer Group on advanced renal cell carcinoma management in Brazil. METHODS: A panel of 34 oncologists and experts in renal cell carcinoma discussed and voted on the best options for managing advanced disease in Brazil, including systemic treatment of early and metastatic renal cell carcinoma as well as nonclear cell tumours...
April 9, 2024: Journal of Cancer Research and Clinical Oncology
#13
EDITORIAL
Genti Xhepa, Gianpaolo Carrafiello, Alexis Ricoeur
No abstract text is available yet for this article.
April 8, 2024: Cardiovascular and Interventional Radiology
#14
JOURNAL ARTICLE
Hannah Warren, Aleksandra Rautio, Laura Marandino, Nikolaos Pyrgidis, Lazaros Tzelves, Eduard Roussel, Stijn Muselaers, Selcuk Erdem, Carlotta Palumbo, Daniele Amparore, Zhenjie Wu, Chiara Ciccarese, Pietro Diana, Leonardo Borregales, Nicola Pavan, Angela Pecoraro, Anna Caliò, Tobias Klatte, Umberto Carbonara, Michele Marchioni, Riccardo Bertolo, Riccardo Campi, Maxine G B Tran
BACKGROUND AND OBJECTIVE: Renal tumour biopsy (RTB) can help in risk stratification of renal tumours with implications for management, but its utilisation varies. Our objective was to report current practice patterns, experiences, and perceptions of RTB and research gaps regarding RTB for small renal masses (SRMs). METHODS: Two web-based surveys, one for health care providers (HCPs) and one for patients, were distributed via the European Association of Urology Young Academic Urologist Renal Cancer Working Group and the European Society of Residents in Urology in January 2023...
April 2024: European urology open science
#15
JOURNAL ARTICLE
Heng Zhang, Hang Yang, Xue-Mei Liu, Jie Ying, Tong Zu, Jing Jiang, Ming-Ming Liu, Juan Jin
Paraquat (PQ) causes fatal poisoning that leads to systemic multiple organ fibrosis, and transforming growth factor (TGF)-β1 plays a critical role in this process. In this study, we aimed to investigate the effects of AZ12601011 (a small molecular inhibitor of TGFβRI) on PQ-induced multiple organ fibrosis. We established a mouse model of PQ in vivo and used PQ-treated lung epithelial cell (A549) and renal tubular epithelial cells (TECs) in vitro. Haematoxylin-eosin and Masson staining revealed that AZ12601011 ameliorated pulmonary, hepatic, and renal fibrosis, consistent with the decrease in the levels of fibrotic indicators, alpha-smooth muscle actin (α-SMA) and collagen-1, in the lungs and kidneys of PQ-treated mice...
March 2024: Pesticide Biochemistry and Physiology
#16
Mohammad Hourani, Selvaraj Giridharan, Fathi Azribi, Hidayath Ansari, Jawaher Ansari
We report a distinctive case of malignant oncocytic carcinoma originating in the pancreas, an organ rarely associated with such tumours. We discuss the diagnostic journey, highlighting the tumour's resemblance to renal cell carcinoma but without renal involvement. A significant aspect of this case is the successful and sustained response to combined immunotherapy and tyrosine kinase inhibitors, demonstrating a potential therapeutic pathway for similar rare cases. This study contributes to a deeper understanding of pancreatic oncocytic tumours and their management...
2024: Case Reports in Oncological Medicine
#17
Zahraa M M Zeer, Mahmoud Noman, Almotazbellah M M Zeer, Yamama Hasan Mahamid, Hasan Arafat, Malak Abomoch, Bashir Abu Aqeel
INTRODUCTION: Multiple primary malignancies (MPM) may be in one organ or in multiple separate organs. They are categorized into synchronous and metachronous according to the time interval between the two malignancies. Multiple risk factors could be attributed to the development of second primary malignancy. CASE PRESENTATION: The authors report a case of a 51-year-old male patient with renal cell carcinoma. During his evaluation, he seemed to have a lung mass which revealed to be a carcinoid tumour...
April 2024: Annals of Medicine and Surgery
#18
Manish Kc, Himal Bikram Bhattarai, Pratik Subedi, Ashutosh Kashyap, Manish Wadhwa, Dania Kaur, Sabina Koirala, Swotantra Gautam
INTRODUCTION: Renal cell carcinoma, a common kidney tumour which is often incidentally discovered on imaging, can manifest with atypical symptoms. Renal cell carcinoma with rhabdoid features is a rare occurrence and even rarer in case of adults. Renal cell carcinoma has the tendency to form thrombus that can migrate to renal vein, inferior vena cava and even right atrium. CASE PRESENTATION: The authors report a case of an 81-year-old male with rhabdoid renal cell carcinoma presenting with persistent cough for 6-7 months...
April 2024: Annals of Medicine and Surgery
#19
JOURNAL ARTICLE
Shichao Li, Ziling Zhou, Mengmeng Gao, Zhouyan Liao, Kangwen He, Weinuo Qu, Jiali Li, Ihab R Kamel, Qian Chu, Qingpeng Zhang, Zhen Li
OBJECTIVES: Accurate preoperative prediction of the pathological grade of clear cell renal cell carcinoma (ccRCC) is crucial for optimal treatment planning and patient outcomes. This study aims to develop and validate a deep-learning (DL) algorithm to automatically segment renal tumours, kidneys, and perirenal adipose tissue (PRAT) from computed tomography (CT) images and extract radiomics features to predict the pathological grade of ccRCC. METHODS: In this cross-ethnic retrospective study, a total of 614 patients were divided into a training set (383 patients from the local hospital), an internal validation set (88 patients from the local hospital), and an external validation set (143 patients from the public dataset)...
April 3, 2024: International Journal of Surgery
#20
JOURNAL ARTICLE
Shitai Zhu, Hongzhen Peng, Huating Kong, Qinglong Yan, Kai Xia, Lihua Wang, Ying Zhu, Shihua Luo
DNA nanostructures, known for their programmability, ease of modification, and favourable biocompatibility, have gained widespread application in the biomedical field. Among them, Tetrahedral DNA Origami (TDOs), as a novel DNA nanostructure, possesses well-defined structures, multiple modification sites, and large cavities, making it a promising drug carrier. However, current understanding of TDOs' interactions with biological systems, particularly with target cells and organs, remains unexplored, limiting its further applications in biomedicine...
April 4, 2024: Cell Proliferation
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