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https://www.readbyqxmd.com/read/28803678/laparoscopic-partial-nephrectomy-with-prior-superselective-embolisation-as-treatment-for-giant-renal-angiomyolipoma
#1
A Husillos Alonso, D Subirá Ríos, E Bolufer Moragues, I Lopez Díez, I Moncada Iribarren, C González Enguita
OBJECTIVE: Cases of giant renal angiomyolipoma (>9cm) are a therapeutic challenge due to their low frequency and large size. The treatment objective for patients with renal angiomyolipoma should be complete tumour extirpation, with a nephron-sparing surgical technique, without complications and using a minimally invasive approach. MATERIAL AND METHODS: We present 3 cases of giant angiomyolipoma (10 12 and 14cm) treated with a combined approach: superselective embolisation and subsequent laparoscopic partial nephrectomy, in 3 separate hospitals...
August 10, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28803033/the-risk-of-tumour-recurrence-in-patients-undergoing-renal-transplantation-for-end-stage-renal-disease-after-previous-treatment-for-a-urological-cancer-a-systematic-review
#2
REVIEW
Romain Boissier, Vital Hevia, Harman Max Bruins, Klemens Budde, Arnaldo Figueiredo, Enrique Lledó-García, Jonathon Olsburgh, Heinz Regele, Claire Fraser Taylor, Rhana Hassan Zakri, Cathy Yuhong Yuan, Alberto Breda
CONTEXT: Renal transplantation is the gold standard renal replacement therapy in end-stage renal disease owing to its superior survival and quality of life compared with dialysis. When the potential recipient has a history of cancer, the waiting period before radiotherapy is usually based on the Cincinnati Registry. OBJECTIVE: To systematically review all available evidence on the risk of cancer recurrence in end-stage renal disease patients with a history of urological cancer...
August 9, 2017: European Urology
https://www.readbyqxmd.com/read/28801336/isolated-clival-metastasis-a-rare-presentation-of-renal-cell-carcinoma
#3
Anil Mani, Priyank Yadav, Vimal Kumar Paliwal, Hira Lal
Renal cell carcinoma accounts for 3% of all adult malignancies. Usual sites of metastasis are lymph nodes, lungs, bone, liver and brain. We describe a patient who presented with complaints of holocranial headache and diplopia. MRI of the head showed a clival-based lesion with associated bony erosion. With suspicion of a metastatic lesion, an ultrasonogram of the abdomen was done which showed a left renal mass that enhanced on contrast-enhanced CT. There were no other metastatic foci. Patient underwent radiotherapy for the clival lesion...
August 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28801061/european-temporal-trends-in-the-use-of-lymph-node-dissection-in-patients-with-renal-cancer
#4
U Capitanio, G D Stewart, A Larcher, I Ouzaid, B Akdogan, M Roscigno, M Marszalek, P Dell'Oglio, M Salagierski, A Volpe, M C Mir, M Kriegmair, C Terrone, S D Brookman-May, F Montorsi, T Klatte
BACKGROUND: The role of lymph node dissection (LND) in renal cell carcinoma (RCC) is still under debate. We aimed to assess the utilization rates of LND over time in Europe. METHODS: A multi-institutional database of 13,581 RCC patients who underwent radical nephrectomy (RN) or nephron sparing surgery (NSS) between 1988 and 2014 was created within an European consortium. We analysed temporal trends in the frequency of LND by using Joinpoint regression. Logistic regression models were used to identify predictors of LND...
August 3, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28794881/procalcitonin-a-promising-diagnostic-marker-for-sepsis-and-antibiotic-therapy
#5
REVIEW
Ashitha L Vijayan, Vanimaya, Shilpa Ravindran, R Saikant, S Lakshmi, R Kartik, Manoj G
BACKGROUND: Sepsis is a global healthcare problem, characterized by whole body inflammation in response to microbial infection, which leads to organ dysfunction. It is becoming a frequent complication in hospitalized patients. Early and differential diagnosis of sepsis is needed critically to avoid unnecessary usage of antimicrobial agents and for proper antibiotic treatments through the screening of biomarkers that sustains with diagnostic significance. MAIN BODY OF ABSTRACT: Current targeting conventional markers (C-reactive protein, white blood cell, tumour necrosis factor-α, interleukins, etc...
2017: Journal of Intensive Care
https://www.readbyqxmd.com/read/28782322/congenital-adrenal-hyperplasia-with-11-beta-hydroxylase-deficiency-with-testicular-adrenal-rest-tumour
#6
Archana Sonawale, Anjali Rajadhyaksha, Siddharth Warrier, Rohit Shriwastav, Nilakshi H Sabnis
Congenital adrenal hyperplasia refers to the non-malignant enlargement of adrenal gland tissue as a result of deficiency of one of several enzymes involved in adrenal hormone synthesis, secondary to a genetic mutation. 11 - Beta hydroxylase is one such enzyme, and its deficiency is a rare cause of Congenital Adrenal Hyperplasia. We describe the case of an 18-year old man who presented to us with an acute right ganglio-capsular bleed, hypertension and bilateral scrotal swelling. Investigations revealed hypokalemia, and normal renal and cardiac functions...
June 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28780300/observation-after-cytoreductive-nephrectomy-in-patients-with-synchronous-not-completely-resected-metastases-of-renal-cell-carcinoma
#7
Roderick E de Bruijn, Teele Kuusk, Allard P Noe, Christian U Blank, John B A G Haanen, Kees Hendricksen, Simon Horenblas, Axel Bex
OBJECTIVE: To determine the time-to-targeted therapy (TTT) in patients with not completely resected low-volume oligometastatic disease who were observed following debulking cytoreductive nephrectomy (CN) for metastatic renal cell carcinoma (mRCC). MATERIALS AND METHODS: Patients with sychronous mRCC with not completely resected low-volume metastases and in whom observation after CN was a multidisciplinary tumour board recommendation were identified from an approved institutional database...
August 2, 2017: Urology
https://www.readbyqxmd.com/read/28775319/circulating-tumour-cell-release-after-cement-augmentation-of-vertebral-metastases
#8
Malte Mohme, Sabine Riethdorf, Marc Dreimann, Stefan Werner, Cecile L Maire, Simon A Joosse, Frederic Bludau, Volkmar Mueller, Rui P L Neves, Nikolas H Stoecklein, Katrin Lamszus, Manfred Westphal, Klaus Pantel, Harriet Wikman, Sven O Eicker
Cement augmentation via percutaneous vertebroplasty or kyphoplasty for treatment of spinal metastasis is a well-established treatment option. We assessed whether elevated intrametastatic pressure during cement augmentation results in an increased dissemination of tumour cells into the vascular circulation. We prospectively collected blood from patients with osteolytic spinal column metastases and analysed the prevalence of circulating tumour cells (CTCs) at three time-points: preoperatively, 20 minutes after cement augmentation, and 3-5 days postoperatively...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28770407/ct-fluoroscopy-guided-renal-tumour-cutting-needle-biopsy-retrospective-evaluation-of-diagnostic-yield-safety-and-risk-factors-for-diagnostic-failure
#9
Toshihiro Iguchi, Takao Hiraki, Yusuke Matsui, Hiroyasu Fujiwara, Jun Sakurai, Yoshihisa Masaoka, Hideo Gobara, Susumu Kanazawa
OBJECTIVES: To evaluate retrospectively the diagnostic yield, safety, and risk factors for diagnostic failure of computed tomography (CT) fluoroscopy-guided renal tumour biopsy. METHODS: Biopsies were performed for 208 tumours (mean diameter 2.3 cm; median diameter 2.1 cm; range 0.9-8.5 cm) in 199 patients. One hundred and ninety-nine tumours were ≤4 cm. All 208 initial procedures were divided into diagnostic success and failure groups. Multiple variables related to the patients, lesions, and procedures were assessed to determine the risk factors for diagnostic failure...
August 2, 2017: European Radiology
https://www.readbyqxmd.com/read/28770105/multi-parametric-profiling-of-renal-cell-colorectal-and-ovarian-cancer-identifies-tumour-type-specific-stroma-phenotypes-and-a-novel-vascular-biomarker
#10
Sara Corvigno, Magnus Frödin, G Bea A Wisman, Hans W Nijman, Ate Gj Van der Zee, Karin Jirström, Björn Nodin, Ina Hrynchyk, David Edler, Peter Ragnhammar, Martin Johansson, Hanna Dahlstrand, Artur Mezheyeuski, Arne Östman
A novel set of integrated procedures for quantification of fibroblast-rich stroma and vascular characteristics has recently been presented allowing discovery of novel perivascular and stromal biomarkers in colorectal, renal cell, and ovarian cancer. In the present study, data obtained through these procedures from clinically well-annotated collections of these three tumour types have been used to address two novel questions. First, data have been used to investigate if the three tumour types demonstrate significant differences regarding features such as vessel diameter, vessel density, and perivascular marker expression...
July 2017: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/28768698/the-future-advances-in-therapeutic-approach-and-management-strategies-for-men1
#11
Rachel S van Leeuwaarde, Joanne M de Laat, Carolina R C Pieterman, Koen M A Dreijerink, Menno Vriens, Gerlof D Valk
Multiple endocrine neoplasia type 1 is a rare autosomal inherited disorder associated with a high risk for patients to simultaneously develop tumours of the parathyroid glands, duodeno-pancreatic neuroendocrine tumors and tumors of the anterior pituitary gland. Early identification of MEN1 in patients enables presymptomatic screening of manifestations which makes timely interventions possible with the intention to prevent morbidity and mortality. Causes of death nowadays have shifted towards local or metastatic progression of malignant neuro endocrine tumors...
August 2, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28767184/antithrombin-iii-prevents-progression-of-chronic-kidney-disease-following-experimental-ischaemic-reperfusion-injury
#12
Jianyong Yin, Feng Wang, Yiwei Kong, Rui Wu, Guangyuan Zhang, Niansong Wang, Ling Wang, Zeyuan Lu, Mingyu Liang
Acute kidney disease (AKI) leads to increased risk of progression to chronic kidney disease (CKD). Antithrombin III (ATIII) is a potent anticoagulant with anti-inflammatory properties, and we previously reported that insufficiencies of ATIII exacerbated renal ischaemia-reperfusion injury (IRI) in rats. In this study, we examined the characteristic of AKI-CKD transition in rats with two distinct AKI models. Based on our observation, left IRI plus right nephrectomy (NX-IRI) was used to determine whether ATIII had therapeutic effects in preventing CKD progression after AKI...
August 2, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28762779/editorial-comment-on-end-2016-0871-or-r2-role-of-mitomycin-c-mmc-topical-treatment-for-upper-tract-urothelial-carcinoma-utuc
#13
Bhaskar K Somani
While adjuvant topical mitomycin C (MMC) is well established in realms of bladder cancer, its use in upper tract urothelial tumours (UTUC) is still somewhat limited with only few series reported worldwide. The authors present their series of 27 patients (28 renal units) on the role of adjuvant MMC after complete endoscopic control of UTUC with a median follow-up of 19 months (7-92 months). Their recurrence free survival of 62% at 3 years represents a medium term favourable result, especially in low-grade tumours...
August 1, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28761743/checkpoint-inhibitors-in-the-treatment-of-urological-malignancies
#14
REVIEW
Lazar S Popovic, Gorana Matovina-Brko, Maja Popovic
Checkpoint inhibitors are monoclonal antibodies attach to several different receptors on T-cells or tumour cells expressing receptors for cytotoxic T-lymphocyte antigen 4 (CTLA-4), programmed death-1 (PD-1) and their ligand (PD-L1). Since 2010, numerous trials on different tumour types have been conducted, which was resulted in these drugs being approved for the treatment of melanoma, lung cancer, Hodgkin's lymphoma and head and neck cancers. Urological cancers, especially urothelial and renal-cell carcinomas, are immunogenic tumours...
2017: ESMO Open
https://www.readbyqxmd.com/read/28761590/conservative-treatment-of-upper-urinary-tract-carcinoma-long-term-results
#15
Andrea Orosa Andrada, Inés Laso García, Fernando Arias Fúnez, Francisco Donis Canet, Gemma Duque Ruiz, Victoria Gómez Dos Santos, Francisco Javier Burgos Revilla
INTRODUCTION: We sought to assess the long-term results of conservative treatment for upper urinary tract carcinoma (UUTC) with regard to tumour recurrence and preservation of renal unit. METHODS: From October 1987 to January 2014, 65 patients (median age 68 years) were diagnosed with UUTC and underwent endoscopic and open surgical techniques. Thirteen patients had bilateral disease and one had a single kidney. The primary approach was endoscopic in 37 reno-ureteral units (20 percutaneous resections, 17 ureteroscopies )...
July 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28761585/early-clamp-release-during-laparoscopic-partial-nephrectomy-implications-for-preservation-of-renal-function
#16
Jeffrey Campbell, Garson Chan, Patrick P Luke
INTRODUCTION: Intraoperative warm ischemic time (WIT), associated with hilar clamping during partial nephrectomy (PN), is an established modifiable risk factor for renal dysfunction. We assessed early clamp release (ECR) as a strategy to reduce WIT and assess its impact on renal function and bleeding. METHODS: We retrospectively assessed patients who underwent minimally invasive PN by a single surgeon at our centre since December 2011. Comparing the standard technique to an ECR modification, WIT, complications, change in estimated glomerular filtration rate (eGFR), and change in differential function as demonstrated by MAG-3 nuclear renography were assessed...
July 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28758762/-leiomyoma-of-external-iliac-vein
#17
V Sihotský, P Berek, I Kopolovets, M Kubíková, M Frankovičová
Authors present a case report of a patient who was diagnosed with a tumour of external iliac vein. Excision of venous wall with tumour and reconstruction of external iliac vein with venous patch was performed. Postoperative course was without complication. The patient is without complications and also without signs of recurrence in one year follow up. Tumours of venous wall are rare. They originate from vena cava inferior, less often from extremity veins. The most frequent primary tumours of vein wall are leiomyosarcomas...
2017: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/28756136/addressing-the-best-treatment-for-non-clear-cell-renal-cell-carcinoma-a-meta-analysis-of-randomised-clinical-trials-comparing-vegfr-tkis-versus-mtori-targeted-therapies
#18
Chiara Ciccarese, Roberto Iacovelli, Matteo Brunelli, Francesco Massari, Davide Bimbatti, Emanuela Fantinel, Vincenzo De Marco, Antonio Benito Porcaro, Guido Martignoni, Walter Artibani, Giampaolo Tortora
AIM: Non-clear cell renal cell carcinoma (nccRCC) tumours include a heterogeneous group of malignancies that profoundly differ in terms of morphology, genetic profile, clinical behaviour and prognosis. The optimal treatment algorithm for nccRCC is still unknown and derived mainly from evidence available for ccRCC, being therefore represented by targeted agents against vascular endothelial growth factor and mammalian target of rapamycin (mTOR) pathways. We aimed to compare the efficacy of vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKis) and mTOR inhibitors (mTORi) for the treatment of nccRCC patients...
July 27, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28753867/does-the-unexpected-presence-of-non-organ-confined-disease-at-final-pathology-undermine-cancer-control-in-patients-with-clinical-t1n0m0-renal-cell-carcinoma-who-underwent-partial-nephrectomy
#19
Umberto Capitanio, Grant D Stewart, Tobias Klatte, Bulent Akdogan, Marco Roscigno, Martin Marszalek, Paolo Dell'Oglio, Emanuele Zaffuto, Oscar Rodriguez Faba, Maciej Salagierski, James Lingard, Marco Carini, Idir Ouzaid, Maria Carmen Mir, Francesco Montorsi, Luigi Filippo Da Pozzo, Christian Stief, Andrea Minervini, Sabine D Brookman-May
BACKGROUND: A non-negligible proportion of individuals diagnosed with cT1 renal cell carcinoma (RCC) are upstaged to pT3a at final pathology. Few data on oncological outcomes for these patients are available to determine whether partial nephrectomy (PN) might jeopardise cancer control. OBJECTIVE: To assess, within an international multi-institutional collaboration, whether PN might undermine cancer control relative to radical nephrectomy (RN) in RCC patients with unexpected pT3a disease...
March 21, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28750749/incidental-focal-colonic-uptake-in-studies-18-f-fdg-pet-ct
#20
L Servente, V Gigirey, M García Fontes, O Alonso
OBJECTIVES: To assess the frequency of focal colonic uptake as an incidental observation in (18)F-FDG PET/CT studies, and to correlate this finding with histopathological results. MATERIAL AND METHODS: Out of a total of 3,176 PET/CT studies with (18)F-FDG systematic analysis was carried out on 30 studies in which colonic focal uptake was observed. Patients with known colorectal neoplasia were excluded. The maximum standardised uptake values (SUVm) and the morphological findings provided by the CT were recorded...
July 24, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
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