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Chemotherapy-induced thrombocytopenia

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https://www.readbyqxmd.com/read/27668103/immune-thrombocytopenia-in-a-child-with-t-cell-lymphoblastic-lymphoma
#1
Kayo Tokeji, Sachi Sakaguchi, Tomoko Kurimoto, Junya Fujimura, Toshiaki Shimizu
We describe the case of a 13-year-old boy who presented with persistent thrombocytopenia during maintenance chemotherapy with mercaptopurine and methotrexate for T cell lymphoblastic lymphoma. He was diagnosed with immune thrombocytopenia (ITP) after thorough investigations for the relapse of lymphoma and was successfully treated with immunoglobulin and steroids. ITP is known to be associated with chronic lymphocytic leukemia, Hodgkin lymphoma, and various types of non-Hodgkin lymphoma but rarely with T cell non-Hodgkin lymphoma or in children...
2016: Case Reports in Hematology
https://www.readbyqxmd.com/read/27639907/-rituximab-induced-acute-thrombocytopenia-in-a-patient-with-chronic-lymphocytic-leukemia
#2
M Bobot, M Benzaquen, F Rouby, D Lebowitz, J Serratrice, J-M Durand
INTRODUCTION: Rituximab is a chimeric anti-CD20 monoclonal antibody generally well tolerated. However, a severe but rare rituximab-related immune-toxic syndrome, associating fever, chills and thrombocytopenia can occur shortly after the infusion. CASE REPORT: We report a case of severe acute rituximab-induced thrombocytopenia with favorable outcome in a patient with chronic lymphocytic leukemia and discuss the possible underlying mechanisms. CONCLUSION: Despite the potential initial severity of rituximab-induced thrombocytopenia in CLL, chemotherapy should not be discontinued; tolerance might increase as the hematologic disorder is controlled...
September 14, 2016: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/27456925/factors-influencing-the-efficacy-of-platelet-transfusions-in-acute-leukemia
#3
A Wahlin, L Eliasson, H Jonsson
The efficacy of platelet transfusions was evaluated in a prospective study of 37 patients with acute leukemia. The patients received 495 platelet transfusions for chemotherapy-induced thrombocytopenia. Life table analysis was found to be useful for prediction of the platelet level after transfusion. Efficacy was positively correlated with platelet content in the concentrate, and inversely correlated with bleeding. Fever, contamination of the: concentrate by leukocytes, or previous platelet transfusions were not found to have any significant influence on the efficacy, as analyzed by multiple regression...
1990: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27425556/gradual-thrombocytopenia-induced-by-long-term-trastuzumab-exposure
#4
M Miarons, M Velasco, L Campins, S Fernández, T Gurrera, L Lopez-Viaplana
WHAT IS KNOWN AND OBJECTIVE: Unexplained thrombocytopenia is a common clinical problem, and the possibility of drug-induced thrombocytopenia must be considered. Moreover, chemotherapy agents are known to typically cause thrombocytopenia by suppressing haematopoiesis, but they can also cause immune thrombocytopenia in which the mechanism involves antibody-mediated platelet destruction. CASE DESCRIPTION: We report a case of severe thrombocytopenia related to trastuzumab administration in which the patient exhibits a slow drift downward in platelet counts with repeated cycles of trastuzumab...
October 2016: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/27316438/a-phase-1-dose-finding-and-pharmacokinetic-study-of-gemcitabine-with-nab-paclitaxel-in-patients-with-metastatic-breast-cancer
#5
Seiji Yoshitomi, Naruto Taira, Hiroyoshi Doihara, Taeko Mizoo, Tomohiro Nogami, Takayuki Iwamoto, Takayuki Motoki, Tadahiko Shien, Yutaka Ogasawara, Junji Matsuoka, Hisashi Tsuji, Toshiharu Mitsuhashi
PURPOSE: Gemcitabine (Gem) with paclitaxel (Pac) is used for patients with metastatic breast cancer who require cytoreduction with manageable toxicities. Nanoparticle albumin-bound (nab)-Pac exhibits better efficacy and reduces the risk of hypersensitivity reactions associated with solvent-based Pac. Therefore, Gem plus nab-Pac (GA) therapy may be effective for metastatic breast cancer. The purpose of this study was to determine the maximum tolerated dose for GA therapy. METHODS: The subjects were patients with metastatic breast cancer with performance status 0 or 1 and normal hepatic, renal and marrow function...
August 2016: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/27228575/the-effect-of-amifostine-on-differentiation-of-the-human-megakaryoblastic-dami-cell-line
#6
Hai-Tao Wang, Bo Yang, Bo Hu, Xiao-Hua Chi, Long-Long Luo, Hong-Qi Yang, Xiao-Ling Lang, Jing Geng, Chun-Xia Qiao, Yan Li, Xiao-Xiong Wu, Hong-Li Zhu, Ming Lv, Xue-Chun Lu
Amifostine is a cytoprotective drug that was initially used to control and treat nuclear radiation injury and is currently used to provide organ protection in cancer patients receiving chemotherapy. Clinical studies have also found that amifostine has some efficacy in the treatment of cytopenia caused by conditions such as myelodysplastic syndrome and immune thrombocytopenia, both of which involve megakaryocyte maturation defects. We hypothesized that amifostine induced the differentiation of megakaryocytes and investigated this by exposing the human Dami megakaryocyte leukemia cell line to amifostine (1 mmol/L)...
August 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27191003/in-vivo-chemoprotective-activity-of-bovine-dialyzable-leukocyte-extract-in-mouse-bone-marrow-cells-against-damage-induced-by-5-fluorouracil
#7
Erika Evangelina Coronado-Cerda, Moisés Armides Franco-Molina, Edgar Mendoza-Gamboa, Heriberto Prado-García, Lydia Guadalupe Rivera-Morales, Pablo Zapata-Benavides, María Del Carmen Rodríguez-Salazar, Diana Caballero-Hernandez, Reyes Silvestre Tamez-Guerra, Cristina Rodríguez-Padilla
Chemotherapy treatments induce a number of side effects, such as leukopenia neutropenia, peripheral erythropenia, and thrombocytopenia, affecting the quality of life for cancer patients. 5-Fluorouracil (5-FU) is wieldy used as myeloablative model in mice. The bovine dialyzable leukocyte extract (bDLE) or IMMUNEPOTENT CRP® (ICRP) is an immunomodulatory compound that has antioxidants and anti-inflammatory effects. In order to investigate the chemoprotection effect of ICRP on bone marrow cells in 5-FU treated mice, total bone marrow (BM) cell count, bone marrow colony forming units-granulocyte/macrophage (CFU-GM), cell cycle, immunophenotypification, ROS/superoxide and Nrf2 by flow cytometry, and histological and hematological analyses were performed...
2016: Journal of Immunology Research
https://www.readbyqxmd.com/read/27167627/the-effect-of-chemotherapy-induced-anemia-on-dose-reduction-and-dose-delay
#8
Leila Family, Lanfang Xu, Hairong Xu, Kimberly Cannavale, Olivia Sattayapiwat, John H Page, Chet Bohac, Chun Chao
PURPOSE: To evaluate moderate (grade 2, hemoglobin <10 g/dl) and severe (grade 3+, hemoglobin <8 g/dl) anemia as potential risk factors for DDR in the first line course of chemotherapy. While chemotherapy-induced neutropenia has been shown to be associated with dose delay/reduction (DDR) in several studies, the effect of anemia is less well studied. METHODS: We identified 3955 Kaiser Permanente patients diagnosed with incident non-Hodgkin's lymphoma (n = 574), breast (n = 2043), lung (n = 463), gastric (n = 113), ovarian (n = 204), or colorectal cancers (n = 558) between 2010 and 2012...
October 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27161680/oc-08-multiple-functional-defects-in-platelets-from-thrombocytopenic-cancer-patients-undergoing-chemotherapy
#9
C C F M J Baaten, F C J I Moenen, Y M C Henskens, F Swieringa, R Wetzels, R van Oerle, H Ten Cate, E A M Beckers, J W M Heemskerk, P E J van der Meijden
INTRODUCTION: Severe thrombocytopenia (≤50×10(9) platelets/L) is often the consequence of hematological malignancies and intensive chemotherapy. The risk of clinically significant bleeding is increased in these patients, despite the use of prophylactic platelet transfusions. The fact that there is no clear correlation between the platelet count and the risk of hemorrhage, suggests that there are other contributing factors. The contribution of impairments in platelet and coagulant function remains poorly understood...
April 2016: Thrombosis Research
https://www.readbyqxmd.com/read/27101362/a-critical-balance-managing-coagulation-in-patients-with-glioma
#10
Erin R Morgan, Warren P Mason, Catherine Maurice
Cancer-associated thrombosis, including both arterial and venous thromboembolism (VTE), is a significant source of morbidity and mortality in patients with glioma. This risk is highest in the immediate postoperative period and is increased by chemotherapy, radiation, and corticosteroids. Systemic anticoagulation with low molecular weight heparin is the treatment of choice in both the therapeutic and prophylactic settings. However, these patients are also at risk of intracranial hemorrhage, a potentially catastrophic complication of anticoagulation, and this risk must be carefully balanced against the risk of VTE...
July 2016: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/27100842/regulation-of-platelet-lifespan-by-apoptosis
#11
Marion Lebois, Emma C Josefsson
The lifespan of platelets in circulation is brief, close to 10 days in humans and 5 days in mice. Bone marrow residing megakaryocytes produce around 100 billion platelets per day. In a healthy individual, the majority of platelets are not consumed by hemostatic processes, but rather their lifespan is controlled by programmed cell death, a canonical intrinsic apoptosis program. In the last decade, insights from genetically manipulated mouse models and pharmacological developments have helped to define the components of the intrinsic, or mitochondrial, apoptosis pathway that controls platelet lifespan...
September 2016: Platelets
https://www.readbyqxmd.com/read/27073478/effects-of-decitabine-on-megakaryocyte-maturation-in-patients-with-myelodysplastic-syndromes
#12
Kai Ding, Rong Fu, Hui Liu, Deepak Anil Nachnani, Zong-Hong Shao
Thrombocytopenia is a common, often fatal complication experienced by patients with myelodysplastic syndromes (MDS). 5-aza-2'-deoxycytidine (decitabine) has been used to treat MDS patients with thrombocytopenia with a response rate of 45-50%. However, the mechanism of its effects on megakaryocytes remains unclear. In the present study, the effect of decitabine on megakaryocyte maturation was investigated. A total of 20 MDS patients diagnosed with thrombocytopenia were enrolled, including 16 refractory anemia with excess blasts (RAEB)-1 patients and 4 RAEB-2 patients], in addition to 20 leukemia patients that had achieved complete remission and 20 healthy donors...
April 2016: Oncology Letters
https://www.readbyqxmd.com/read/27064021/minimally-myelosuppressive-asparaginase-containing-induction-regimen-for-treatment-of-a-jehovah-s-witness-with-mutant-idh1-npm1-nras-acute-myeloid-leukemia
#13
Ashkan Emadi, Najeebah A Bade, Brandi Stevenson, Zeba Singh
Treatment of patients with acute myeloid leukemia (AML) who do not wish to accept blood product transfusion, including Jehovah's Witnesses, is extremely challenging. The use of conventional chemotherapy for induction of complete remission (CR) results in profound anemia and thrombocytopenia requiring frequent transfusions of blood products, without which such treatment will be life-threatening. Finding a well tolerable, minimally myelosuppressive induction regimen for such patients with AML is a clear example of area of unmet medical need...
March 10, 2016: Pharmaceuticals
https://www.readbyqxmd.com/read/27057370/paclitaxel-induced-mds-and-aml-a-case-report-and-literature-review
#14
Udit Bhaskar Bhatnagar, Daulath Singh, Alexy Glazyrin, Jill Moormeier
Therapy related acute myelogenous leukemia (AML) and myelodysplastic syndromes (MDS) have been classically linked to alkylating agents and topoisomerase inhibitors. They constitute about 1% of all AMLs. There is less evidence on association of taxanes (paclitaxel and docetaxel) with these myeloid neoplasms. We present a case of paclitaxel therapy related acute myelogenous leukemia after treatment of endometrial cancer with a regimen containing paclitaxel and carboplatin. A 63-year-old female underwent surgery followed by a total of 6 cycles of chemotherapy with carboplatin and paclitaxel...
2016: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/26979913/oxaliplatin-immune-induced-syndrome-occurs-with-cumulative-administration-and-rechallenge-single-institution-series-and-systematic-review-study
#15
REVIEW
Katia Bencardino, Gianluca Mauri, Alessio Amatu, Federica Tosi, Erica Bonazzina, Laura Palmeri, Marialuisa Querques, Federica Ravera, Alberto Menegotto, Elisa Boiani, Andrea Sartore-Bianchi, Salvatore Siena
Oxaliplatin immune-induced syndrome (OIIS) is an uncommon, potentially life-threatening, side effect associated with oxaliplatin-based chemotherapy. The present study reports 5 original cases of OIIS and systematically reviewed the available published cases. We retrospectively analyzed the clinical archives of the Niguarda Cancer Center from 2009 to 2015 and conducted a search for OIIS using the PubMed database, followed by deeper investigation of the references of the recorded studies. We pooled our series with other reported cases for systematic review in accordance with the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement using only English language as the selection criterion...
September 2016: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/26942162/acute-hyperammonemic-encephalopathy-after-5-fluorouracil-based-chemotherapy
#16
Hee Jung Yi, Kyung Sook Hong, Nara Moon, Soon Sup Chung, Ryung-Ah Lee, Kwang Ho Kim
5-Fluorouracil (5-FU) based chemotherapy has been commonly used to treat metastatic or advanced colon cancer as an adjuvant chemotherapy. Although the side effects of 5-FU such as gastrointestinal problems and neutropenia and thrombocytopenia are common, not many cases of 5-FU related encephalopathy are reported. Hyperammonemic encephalopathy is a rare central nervous system toxicity following 5-FU chemotherapy manifesting as altered mental status with elevated ammonia levels with no radiologic abnormality...
March 2016: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/26925632/a-clinical-study-on-juheli-recombinant-human-interleukin-11-in-the-second-prevention-of-chemotherapy-induced-thrombocytopenia
#17
Yang Xiao, Jun Liu, Xin-En Huang, Jian-Xiong Guo, Peng-Chao Fu, Xiao-Hong Huang, Juan Zhou, Ai-Qin Ye
OBJECTIVE: to investigate the effect and side effects of recombinant human interleukin - 11 (rhIL - 11, in Chinese Juheli, produced by Qi Lu Biotechnology CO., LTD) in the second prevention of chemotherapy induced thrombocytopenia (CIT). METHODS: Cancer patients with CIT were recruited and were treated with rhIL - 11 (treatment phase, TP), and in the following cycle, all these patients administered with rhIL - 11 24 hours immediately after chemotherapy (preventive treatment phase, PTP)...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/26833144/-clinical-efficacy-of-eculizumab-as-treatment-of-gemcitabine-induced-thrombotic-microangiopathy-a-case-report
#18
T Rogier, M Gerfaud-Valentin, C Pouteil-Noble, A Taleb, M Guillet, A Noel, C Broussolle, P Sève
INTRODUCTION: Gemcitabine-induced thrombotic microangiopathy is a rare event whose management is not yet consensual. The use of eculizumab could be of interest. CASE REPORT: A 68-year-old woman was treated by gemcitabine as adjuvant chemotherapy of a pancreatic adenocarcinoma. Two months later, the patient presented with mechanical hemolytic anemia, thrombocytopenia and high blood pressure that led to the diagnosis of thrombotic microangiopathy. Gemcitabine was stopped...
January 28, 2016: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/26826116/preclinical-characterization-of-g1t28-a-novel-cdk4-6-inhibitor-for-reduction-of-chemotherapy-induced-myelosuppression
#19
John E Bisi, Jessica A Sorrentino, Patrick J Roberts, Francis X Tavares, Jay C Strum
Chemotherapy-induced myelosuppression continues to represent the major dose-limiting toxicity of cytotoxic chemotherapy, which can be manifested as neutropenia, lymphopenia, anemia, and thrombocytopenia. As such, myelosuppression is the source of many of the adverse side effects of cancer treatment including infection, sepsis, bleeding, and fatigue, thus resulting in the need for hospitalizations, hematopoietic growth factor support, and transfusions (red blood cells and/or platelets). Moreover, clinical concerns raised by myelosuppression commonly lead to chemotherapy dose reductions, therefore limiting therapeutic dose intensity, and reducing the antitumor effectiveness of the treatment...
May 2016: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/26811139/chemotherapy-induced-thrombocytopenia-in-pediatric-oncology
#20
REVIEW
Gevorg Tamamyan, Samvel Danielyan, Michele P Lambert
Thrombocytopenia has long been recognized as a significant problem of cancer therapy, but there is still lack of consensus about the optimal approach to prophylaxis and/or treatment of this important complication. In pediatric oncology, since there are very few studies dedicated to this problem, the knowledge gap is even larger and no final conclusions or pediatric evidence based guidelines are available. Those guidelines that are available consist mostly of experts' personal opinions and data extrapolated from the adult studies...
March 2016: Critical Reviews in Oncology/hematology
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