keyword
MENU ▼
Read by QxMD icon Read
search

myofibrillar hypertrophy

keyword
https://www.readbyqxmd.com/read/29099523/a-potential-strategy-for-counteracting-age-related-sarcopenia-preliminary-evidence-of-combined-exercise-training-and-leucine-supplementation
#1
Z Xia, J M Cholewa, Y Zhao, Y Yang, H Shang, H Jiang, Q Su, N E Zanchi
Previous research has demonstrated the positive effects of concurrent/combined aerobic and resistance exercise or leucine supplementation on skeletal muscle protein synthesis (MPS) and hypertrophy in aging organisms. However, the effects of a multimodal intervention which combines both aerobic and resistance exercise and leucine supplementation has not been fully elucidated. Eighteen month old and 2 month old C57BL/6 mice were assigned to aging control (AC, n = 8), aging and multimodal intervention (AMI, n = 8) and young control (YC, n = 8)...
November 3, 2017: Food & Function
https://www.readbyqxmd.com/read/28966596/impact-of-resistance-training-on-skeletal-muscle-mitochondrial-biogenesis-content-and-function
#2
REVIEW
Thomas Groennebaek, Kristian Vissing
Skeletal muscle metabolic and contractile properties are reliant on muscle mitochondrial and myofibrillar protein turnover. The turnover of these specific protein pools is compromised during disease, aging, and inactivity. Oppositely, exercise can accentuate muscle protein turnover, thereby counteracting decay in muscle function. According to a traditional consensus, endurance exercise is required to drive mitochondrial adaptations, while resistance exercise is required to drive myofibrillar adaptations. However, concurrent practice of traditional endurance exercise and resistance exercise regimens to achieve both types of muscle adaptations is time-consuming, motivationally demanding, and contended to entail practice at intensity levels, that may not comply with clinical settings...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28791992/-morphological-features-of-the-myocardium-of-the-atrial-appendages-in-patients-with-different-forms-of-atrial-fibrillation
#3
T V Sukhacheva, V A Vaskovsky, A Sh Revishvili, R A Serov
AIM: to analyze the morphological features of the myocardium of the atrial appendages in patients with different forms of atrial fibrillation (AF) and to compare the findings with the clinical parameters of patients. MATERIAL AND METHODS: Light and electron microscopies were used to examine the myocardium of the atrial appendages in adult patients with paroxysmal (PAF), persistent (PrAF), or long-standing persistent atrial fibrillation (LPAF) and in comparison group patients with sinus rhythm without history of AF...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28759817/left-atrial-remodeling-hypertrophy-and-fibrosis-in-mouse-models-of-heart-failure
#4
Waqas Hanif, Linda Alex, Ya Su, Arti V Shinde, Ilaria Russo, Na Li, Nikolaos G Frangogiannis
Left ventricular dysfunction increases left atrial pressures and causes atrial remodeling. In human subjects, increased left atrial size is a powerful predictor of mortality and adverse events in a broad range of cardiac pathologic conditions. Moreover, structural remodeling of the atrium plays an important role in the pathogenesis of atrial tachyarrhythmias. Despite the potential value of the atrium in assessment of functional endpoints in myocardial disease, atrial pathologic alterations in mouse models of left ventricular disease have not been systematically investigated...
September 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/28592307/global-gene-expression-in-muscle-from-fasted-refed-trout-reveals-up-regulation-of-genes-promoting-myofibre-hypertrophy-but-not-myofibre-production
#5
Pierre-Yves Rescan, Aurelie Le Cam, Cécile Rallière, Jérôme Montfort
BACKGROUND: Compensatory growth is a phase of rapid growth, greater than the growth rate of control animals, that occurs after a period of growth-stunting conditions. Fish show a capacity for compensatory growth after alleviation of dietary restriction, but the underlying cellular mechanisms are unknown. To learn more about the contribution of genes regulating hypertrophy (an increase in muscle fibre size) and hyperplasia (the generation of new muscle fibres) in the compensatory muscle growth response in fish, we used high-density microarray analysis to investigate the global gene expression in muscle of trout during a fasting-refeeding schedule and in muscle of control-fed trout displaying normal growth...
June 7, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28566753/an-integrated-analysis-revealed-different-microrna-mrna-profiles-during-skeletal-muscle-development-between-landrace-and-lantang-pigs
#6
Shuihua Xie, Luxi Chen, Xumeng Zhang, Xiaohong Liu, Yaosheng Chen, Delin Mo
Pigs supply vital dietary proteins for human consumption, and their economic value depends largely on muscle production. MicroRNAs are known to play important roles in skeletal muscle development. However, their relationship to distinct muscle production between pig breeds remains unknown. Here, we performed an integrated analysis of microRNA-mRNA expression profiles for Landrace (LR, lean) pigs and the Chinese indigenous Lantang pig (LT, lard-type) during 8 stages of skeletal muscle developmental, including at 35, 49, 63, 77 dpc (days post coitum) and 2, 28, 90, 180 dpn (days postnatal)...
May 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28523323/discovery-of-a-new-mutation-in-the-desmin-gene-in-a-young-patient-with-cardiomyopathy-and-muscular-weakness
#7
Ruxandra Oana JurcuŢ, Alexandra Eugenia Bastian, Sebastian Militaru, Aura Popa, Emilia Manole, Bogdan Alexandru Popescu, Jonna Tallila, Bogdan Ovidiu Popescu, Carmen Doina Ginghină
A 25-year-old woman with a five years history of syncope, mild left ventricular hypertrophy and moderately enlarged atria, was diagnosed with third degree atrioventricular heart block alternating with atrioventricular heart block 2:1, and received a dual chamber pacemaker. After three years of evolution, she developed atrial fibrillation, marked biatrial enlargement, severely depressed longitudinal myocardial velocities, associated with mild girdle weakness and slight increase in creatine kinase level. The diagnosis of restrictive cardiomyopathy with mild skeletal myopathy imposed the screening for a common etiology...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27780819/light-load-resistance-exercise-increases-muscle-protein-synthesis-and-hypertrophy-signaling-in-elderly-men
#8
RANDOMIZED CONTROLLED TRIAL
Jakob Agergaard, Jacob Bülow, Jacob K Jensen, Søren Reitelseder, Micah J Drummond, Peter Schjerling, Thomas Scheike, Anja Serena, Lars Holm
The present study investigated whether well-tolerated light-load resistance exercise (LL-RE) affects skeletal muscle fractional synthetic rate (FSR) and anabolic intracellular signaling as a way to counteract age-related loss of muscle mass. Untrained healthy elderly (>65-yr-old) men were subjected to 13 h of supine rest. After 2.5 h of rest, unilateral LL-RE, consisting of leg extensions (10 sets, 36 repetitions) at 16% of 1 repetition maximum (RM), was conducted. Subsequently, the subjects were randomized to oral intake of 4 g of whey protein per hour (PULSE, n = 10), 28 g of whey protein at 0 h and 12 g of whey protein at 7 h postexercise (BOLUS, n = 10), or 4 g of maltodextrin per hour (placebo, n = 10)...
April 1, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27618136/mitochondrial-dysfunction-in-myofibrillar-myopathy
#9
Amy E Vincent, John P Grady, Mariana C Rocha, Charlotte L Alston, Karolina A Rygiel, Rita Barresi, Robert W Taylor, Doug M Turnbull
Myofibrillar myopathies (MFM) are characterised by focal myofibrillar destruction and accumulation of myofibrillar elements as protein aggregates. They are caused by mutations in the DES, MYOT, CRYAB, FLNC, BAG3, DNAJB6 and ZASP genes as well as other as yet unidentified genes. Previous studies have reported changes in mitochondrial morphology and cellular positioning, as well as clonally-expanded, large-scale mitochondrial DNA (mtDNA) deletions and focal respiratory chain deficiency in muscle of MFM patients...
October 2016: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/27512143/autophagy-protects-cardiomyocytes-from-the-myocardial-ischaemia-reperfusion-injury-through-the-clearance-of-clp36
#10
Shiguo Li, Chao Liu, Lei Gu, Lina Wang, Yongliang Shang, Qiong Liu, Junyi Wan, Jian Shi, Fang Wang, Zhiliang Xu, Guangju Ji, Wei Li
Cardiovascular disease (CVD) is the leading cause of the death worldwide. An increasing number of studies have found that autophagy is involved in the progression or prevention of CVD. However, the precise mechanism of autophagy in CVD, especially the myocardial ischaemia-reperfusion injury (MI/R injury), is unclear and controversial. Here, we show that the cardiomyocyte-specific disruption of autophagy by conditional knockout of Atg7 leads to severe contractile dysfunction, myofibrillar disarray and vacuolar cardiomyocytes...
August 2016: Open Biology
https://www.readbyqxmd.com/read/27418001/enzymes-and-signal-pathways-in-the-pathogenesis-of-alcoholic-cardiomyopathy
#11
REVIEW
E Leibing, T Meyer
Owing to its acute psychotropic effects, ethanol is the most frequently consumed toxic agent worldwide. However, excessive alcohol intake results in an array of health, social, and economic consequences, which are related to its property as an addictive substance. It has been well established that exposure to high levels of alcohol for a long period leads to the onset and progression of nonischemic cardiomyopathy through direct toxic mechanisms of ethanol and its metabolite, acetaldehyde. Excessive alcohol ingestion causes myocardial damage including disruptions of the myofibrillar architecture and is associated with reduced myocardial contractility and decreased ejection volumes...
September 2016: Herz
https://www.readbyqxmd.com/read/27219125/resistance-training-induced-changes-in-integrated-myofibrillar-protein-synthesis-are-related-to-hypertrophy-only-after-attenuation-of-muscle-damage
#12
Felipe Damas, Stuart M Phillips, Cleiton A Libardi, Felipe C Vechin, Manoel E Lixandrão, Paulo R Jannig, Luiz A R Costa, Aline V Bacurau, Tim Snijders, Gianni Parise, Valmor Tricoli, Hamilton Roschel, Carlos Ugrinowitsch
KEY POINTS: Skeletal muscle hypertrophy is one of the main outcomes from resistance training (RT), but how it is modulated throughout training is still unknown. We show that changes in myofibrillar protein synthesis (MyoPS) after an initial resistance exercise (RE) bout in the first week of RT (T1) were greater than those seen post-RE at the third (T2) and tenth week (T3) of RT, with values being similar at T2 and T3. Muscle damage (Z-band streaming) was the highest during post-RE recovery at T1, lower at T2 and minimal at T3...
September 15, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27208796/tyrosine-phosphorylation-of-rack1-triggers-cardiomyocyte-hypertrophy-by-regulating-the-interaction-between-p300-and-gata4
#13
Hidetoshi Suzuki, Yasufumi Katanasaka, Yoichi Sunagawa, Yusuke Miyazaki, Masafumi Funamoto, Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto
The zinc finger protein GATA4 is a transcription factor involved in cardiomyocyte hypertrophy. It forms a functional complex with the intrinsic histone acetyltransferase (HAT) p300. The HAT activity of p300 is required for the acetylation and transcriptional activity of GATA4, as well as for cardiomyocyte hypertrophy and the development of heart failure. In the present study, we have identified Receptor for Activated Protein Kinase C1 (RACK1) as a novel GATA4-binding protein using tandem affinity purification and mass spectrometry analyses...
September 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27187487/role-of-myofibrillar-protein-catabolism-in-development-of-glucocorticoid-myopathy-aging-and-functional-activity-aspects
#14
REVIEW
Teet Seene, Priit Kaasik
Muscle weakness in corticosteroid myopathy is mainly the result of the destruction and atrophy of the myofibrillar compartment of fast-twitch muscle fibers. Decrease of titin and myosin, and the ratio of nebulin and MyHC in myopathic muscle, shows that these changes of contractile and elastic proteins are the result of increased catabolism of the abovementioned proteins in skeletal muscle. Slow regeneration of skeletal muscle is in good correlation with a decreased number of satellite cells under the basal lamina of muscle fibers...
2016: Metabolites
https://www.readbyqxmd.com/read/26956799/profilin-modulates-sarcomeric-organization-and-mediates-cardiomyocyte-hypertrophy
#15
Viola Kooij, Meera C Viswanathan, Dong I Lee, Peter P Rainer, William Schmidt, William A Kronert, Sian E Harding, David A Kass, Sanford I Bernstein, Jennifer E Van Eyk, Anthony Cammarato
AIMS: Heart failure is often preceded by cardiac hypertrophy, which is characterized by increased cell size, altered protein abundance, and actin cytoskeletal reorganization. Profilin is a well-conserved, ubiquitously expressed, multifunctional actin-binding protein, and its role in cardiomyocytes is largely unknown. Given its involvement in vascular hypertrophy, we aimed to test the hypothesis that profilin-1 is a key mediator of cardiomyocyte-specific hypertrophic remodelling. METHODS AND RESULTS: Profilin-1 was elevated in multiple mouse models of hypertrophy, and a cardiomyocyte-specific increase of profilin in Drosophila resulted in significantly larger heart tube dimensions...
May 15, 2016: Cardiovascular Research
https://www.readbyqxmd.com/read/26913127/home-based-functional-electrical-stimulation-for-long-term-denervated-human-muscle-history-basics-results-and-perspectives-of-the-vienna-rehabilitation-strategy
#16
Helmut Kern, Ugo Carraro
We will here discuss the following points related to Home-based Functional Electrical Stimulation (h-b FES) as treatment for patients with permanently denervated muscles in their legs: 1. Upper (UMN) and lower motor neuron (LMN) damage to the lower spinal cord; 2. Muscle atrophy/hypertrophy versus processes of degeneration, regeneration, and recovery; 3. Recovery of twitch- and tetanic-contractility by h-b FES; 4. Clinical effects of h-b FES using the protocol of the "Vienna School"; 5. Limitations and perspectives...
March 31, 2014: European Journal of Translational Myology
https://www.readbyqxmd.com/read/26861590/dynamic-myofibrillar-remodeling-in-live-cardiomyocytes-under-static-stretch
#17
Huaxiao Yang, Lucas P Schmidt, Zhonghai Wang, Xiaoqi Yang, Yonghong Shao, Thomas K Borg, Roger Markwald, Raymond Runyan, Bruce Z Gao
An increase in mechanical load in the heart causes cardiac hypertrophy, either physiologically (heart development, exercise and pregnancy) or pathologically (high blood pressure and heart-valve regurgitation). Understanding cardiac hypertrophy is critical to comprehending the mechanisms of heart development and treatment of heart disease. However, the major molecular event that occurs during physiological or pathological hypertrophy is the dynamic process of sarcomeric addition, and it has not been observed...
February 10, 2016: Scientific Reports
https://www.readbyqxmd.com/read/26785370/sporadic-inclusion-body-myositis-clinical-pathological-and-genetic-analysis-of-eight-polish-patients
#18
Biruta Kierdaszuk, Mariusz Berdynski, Piotr Palczewski, Marek Golebiowski, Cezary Zekanowski, Anna Maria Kaminska
INTRODUCTION: Sporadic inclusion body myositis (sIBM) is one of the most common myopathies in patients above 50 years of age. Its progressive course finally leads to immobilisation, and no effective therapy exists. Its pathogenesis includes both degenerative and inflammatory processes, however, its direct causes remain unknown. Therefore, a possible genetic background of the disease must also be considered. MATERIAL AND METHODS: Here we report on twelve patients: eight with sporadic inclusion body myositis and four with other myopathies with rimmed vacuoles in muscle biopsy...
2015: Folia Neuropathologica
https://www.readbyqxmd.com/read/26472277/ultrastructural-morphometric-findings-of-cardiomyocytes-in-patients-with-impaired-ventricular-function-a-comparative-clinicopathological-study
#19
COMPARATIVE STUDY
Katharina Wassilew, Denis Terziev, Georgi Wassilew, Günther Fitzl, Karsten Frölich, Reinhard Kandolf, Andreas Fried
AIM: The present study aims to analyze the differences in ultrastructural changes between right ventricular myocardium in clinically determined grades of heart failure (HF) [New York Heart Association (NYHA) classes I-IV] and their value in the routine diagnostic setting. METHODS: We investigated consecutive right ventricular endomyocardial biopsies of 12 patients presenting with HF (49±11.2years; male=10) by light microscopy and ultrastructural morphometric analysis...
January 2016: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/26388513/single-muscle-fibre-contractile-properties-differ-between-body-builders-power-athletes-and-control-subjects
#20
J P Meijer, R T Jaspers, J Rittweger, O R Seynnes, S Kamandulis, M Brazaitis, A Skurvydas, R Pišot, B Šimunič, M V Narici, H Degens
What is the central question of this study? Do the contractile properties of single muscle fibres differ between body-builders, power athletes and control subjects? What is the main finding and its importance? Peak power normalized for muscle fibre volume in power athletes is higher than in control subjects. Compared with control subjects, maximal isometric tension (normalized for muscle fibre cross-sectional area) is lower in body-builders. Although this difference may be caused in part by an apparent negative effect of hypertrophy, these results indicate that the training history of power athletes may increase muscle fibre quality, whereas body-building may be detrimental...
November 2015: Experimental Physiology
keyword
keyword
115053
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"