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https://www.readbyqxmd.com/read/28436962/cancer-immunotherapy-making-allies-of-phagocytes
#1
Steven Fiering
No abstract text is available yet for this article.
April 24, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/28435282/managing-the-patient-with-osteogenesis-imperfecta-a-multidisciplinary-approach
#2
REVIEW
Caroline Marr, Alison Seasman, Nick Bishop
Osteogenesis imperfecta (OI) is a heterogeneous heritable connective tissue disorder characterized by low bone density. The type and severity of OI are variable. The primary manifestations are fractures, bone deformity, and bone pain, resulting in reduced mobility and function to complete everyday tasks. OI affects not only the physical but also the social and emotional well-being of children, young people, and their families. As such, medical, surgical, and allied health professionals' assessments all play a role in the management of these children...
2017: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/28429527/balancing-health-care-education-and-patient-care-in-the-uk-workplace-a-realist-synthesis
#3
Sarah Sholl, Rola Ajjawi, Helen Allbutt, Jane Butler, Divya Jindal-Snape, Jill Morrison, Charlotte Rees
CONTEXT: Patient care activity has recently increased without a proportionate rise in workforce numbers, impacting negatively on health care workplace learning. Health care professionals are prepared in part by spending time in clinical practice, and for medical staff this constitutes a contribution to service. Although stakeholders have identified the balance between health care professional education and patient care as a key priority for medical education research, there have been very few reviews to date on this important topic...
April 20, 2017: Medical Education
https://www.readbyqxmd.com/read/28429199/gastric-bypass-and-influence-on-improvement-of-nafld
#4
REVIEW
Vamsi Alli, Ann M Rogers
PURPOSE OF REVIEW: Obesity is recognized as a chronic and recurring disease, often accompanied by other weight-related comorbid conditions such as obstructive sleep apnea, hypertension, type 2 diabetes, and non-alcoholic fatty liver disease (NAFLD). This chapter will seek to focus on the effect of weight loss surgery (WLS), in particular Roux-en-Y gastric bypass (RYGB), on NAFLD. RECENT FINDINGS: Among several modalities available to treat NAFLD, the one most likely to achieve rapid, significant, and sustained improvement of liver disease is WLS...
June 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28428363/phlpp-a-putative-cellular-target-during-insulin-resistance-and-type-2-diabetes
#5
Alpana Mathur, Vivek Kumar Pandey, Poonam Kakkar
Progressive research in the past decade converges to the impact of PHLPP (Pleckstrin homology domain and leucine rich repeat protein phosphatase) in regulating the cellular metabolism through PI3K/Akt inhibition. Defects in the PKB/Akt signaling coordinates with impaired insulin secretion and insulin resistance, identified during T2D, obesity and cardiovascular disorders which brings in the relevance of PHLPPs in the metabolic paradigm. In this review, we discuss the impact of PHLPP isoforms in insulin signaling and its associated cellular events including mitochondrial dysfunction, DNA damage, autophagy and cell death...
April 20, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28428033/a-critical-analysis-of-limb-symmetry-indices-of-hop-tests-in-athletes-after-anterior-cruciate-ligament-reconstruction-a-case-control-study
#6
Alli Gokeler, Wouter Welling, Anne Benjaminse, Koen Lemmink, Romain Seil, Stefano Zaffagnini
BACKGROUND: Hop tests are frequently used to determine return to sports (RTS) after anterior cruciate ligament reconstruction (ACLR). Given that bilateral deficits are present after ACLR, this may result in a falsely high limb symmetry index (LSI), since LSI is calculated as a ratio between the values of the limbs. HYPOTHESIS: Athletes after ACLR would achieve LSI > 90% for the hop test. Secondly, athletes after ACLR demonstrate decreased jump distance on the single hop for distance (SLH) and triple leg hop for distance (TLH) and decreased number of hops for the side hop (SH) for both involved and uninvolved limbs compared to normative data of sex, age and type of sports matched healthy athletes...
April 17, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28427444/interventions-to-reduce-wait-times-for-primary-care-appointments-a-systematic-review
#7
Dominique Ansell, James A G Crispo, Benjamin Simard, Lise M Bjerre
BACKGROUND: Accessibility and availability are important characteristics of efficient and effective primary healthcare systems. Currently, timely access to a family physician is a concern in Canada. Adverse outcomes are associated with longer wait times for primary care appointments and often leave individuals to rely on urgent care. When wait times for appointments are too long patients may experience worse health outcomes and are often left to use emergency department resources. The primary objective of our study was to systematically review the literature to identify interventions designed to reduce wait times for primary care appointments...
April 20, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28426312/safe-sex-in-the-1970s-community-practitioners-on-the-eve-of-aids
#8
Thomas R Blair
In the 1970s, groups of gay and gay-allied health professionals began to formulate guidelines for safer sexual activity, several years before HIV/AIDS. Through such organizations as the National Coalition of Gay Sexually Transmitted Disease Services, Bay Area Physicians for Human Rights, and the Sisters of Perpetual Indulgence, these practitioners developed materials that would define sexual health education for the next four decades, as well as such concepts as "bodily fluids" and the "safe sex hanky." To do so, they used their dual membership in the community and the health professions...
April 20, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28424776/socially-responsible-surgery-building-recognition-and-coalition
#9
Tyler D Robinson, Thiago M Oliveira, Theresa R Timmes, Jacqueline M Mills, Nichole Starr, Matthew Fleming, Megan Janeway, Diane Haddad, Feroze Sidhwa, Ryan D Macht, Douglas F Kauffman, Tracey A Dechert
IMPORTANCE: Socially responsible surgery (SRS) integrates surgery and public health, providing a framework for research, advocacy, education, and clinical practice to address the social barriers of health that decrease surgical access and worsen surgical outcomes in underserved patient populations. These patients face disparities in both health and in health care, which can be effectively addressed by surgeons in collaboration with allied health professionals. OBJECTIVE: We reviewed the current state of surgical access and outcomes of underserved populations in American rural communities, American urban communities, and in low- and middle-income countries...
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/28423814/ubiquitous-adoption-of-innovative-and-supportive-information-and-communications-technology-across-health-and-social-care-needs-education-for-clinicians
#10
Paula M Procter
The paper presents the development, use and evaluation of an on-line undergraduate module delivering an academic-led programme of eHealth learning within nursing, midwifery, allied health professional and social work courses. The health information technology competency frameworks are explored along with an overview of the resulting module. The need for an academically led module will be made along with a description of the management required to maintain validity of content materials. A review of student evaluations will be presented...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28422682/mri-based-medial-axis-extraction-and-boundary-segmentation-of-cranial-nerves-through-discrete-deformable-3d-contour-and-surface-models
#11
Sharmin Sultana, Jason Blatt, Benjamin Gilles, Tanweer Rashid, Michel Audette
This paper presents a segmentation technique to identify the medial axis and the boundary of cranial nerves. We utilize a 3D deformable 1-simplex discrete contour model to ex-tract the medial axis of each cranial nerve. This contour model represents a collection of 2-connected vertices linked by edges, where vertex position is determined by a Newtonian expression for vertex kinematics featuring internal and external forces, the latter of which include attractive forces towards the nerve medial axis. We exploit multiscale vesselness filtering and minimal path techniques in the medial axis extraction method, which also com-putes a radius estimate along the path...
April 12, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28421661/safety-in-psychiatric-inpatient-care-the-impact-of-risk-management-culture-on-mental-health-nursing-practice
#12
Allie Slemon, Emily Jenkins, Vicky Bungay
The discourse of safety has informed the care of individuals with mental illness through institutionalization and into modern psychiatric nursing practices. Confinement arose from safety: out of both societal stigma and fear for public safety, as well as benevolently paternalistic aims to protect individuals from self-harm. In this paper, we argue that within current psychiatric inpatient environments, safety is maintained as the predominant value, and risk management is the cornerstone of nursing care. Practices that accord with this value are legitimized and perpetuated through the safety discourse, despite evidence refuting their efficacy, and patient perspectives demonstrating harm...
April 18, 2017: Nursing Inquiry
https://www.readbyqxmd.com/read/28421207/detection-of-human-papillomavirus-genotypes-and-epstein-barr-virus-in-nasopharyngeal-carcinomas-at-the-korle-bu-teaching-hospital-ghana
#13
Du-Bois Asante, Richard Harry Asmah, Andrew Anthony Adjei, Foster Kyei, David Larbi Simpong, Charles Addoquaye Brown, Richard Kwasi Gyasi
Nasopharyngeal carcinomas (NPC) are endemic in Far East Asia and commonly harbour Epstein-Barr virus (EBV) which is known to serve as a key oncogenic promoter. Human papillomavirus (HPV) is known to contribute to the pathogenesis of NPC. However, in Ghana these two viruses have not been linked to NPC prevalence. This study was designed to determine the HPV genotypes and EBV involved in NPC tissue biopsies. A retrospective study design involving 72 formalin-fixed paraffin-embedded tissue (FFPET) samples of NPC from 2006 to 2012 were retrieved from the Department of Pathology, University of Ghana School of Biomedical and Allied Health Sciences...
2017: TheScientificWorldJournal
https://www.readbyqxmd.com/read/28420742/synergistic-internal-ribosome-entry-site-microrna-based-approach-for-flavivirus-attenuation-and-live-vaccine-development
#14
Konstantin A Tsetsarkin, Guangping Liu, Evgeniya Volkova, Alexander G Pletnev
The recent emergence of Zika virus underscores the need for new strategies for a rapid development of safe flavivirus vaccines. Using another flavivirus (Langat virus [LGTV]) that belongs to the group of tick-borne flaviviruses as a model, we describe a dual strategy for virus attenuation which synergistically accesses the specificity of microRNA (miRNA) genome targeting and the effectiveness of internal ribosome entry site (IRES) insertion. To increase the stability and immunogenicity of bicistronic LGTVs, we developed a novel approach in which the capsid (C) protein gene was relocated into the 3' noncoding region (NCR) and expressed under translational control from an IRES...
April 18, 2017: MBio
https://www.readbyqxmd.com/read/28419753/systematic-review-of-gender-differences-in-sepsis-management-and-outcomes
#15
Kim Reina Failla, Cynthia D Connelly
PURPOSE: Contributors to disparities in sepsis management have been attributed to genetic susceptibility, differences in clinical presentation, and healthcare delivery. The influence of gender on survival or mortality of patients with sepsis-related diagnoses is unclear. The purpose of the current study was to systematically review published research to identify factors and outcomes associated with sepsis management and outcomes based on gender differences. METHODS: Covering a period from 2006 to 2016, a literature search was conducted on four electronic data bases including the Cumulative Index to Nursing and Allied Health Literature (CINAHL), EBSCO, MedlinePlus, and PubMed...
April 18, 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/28419696/risk-factors-associated-with-pain-on-chronic-intermittent-hemodialysis-a-systematic-review
#16
REVIEW
Tonci Brkovic, Eliana Burilovic, Livia Puljak
OBJECTIVES: The aim of the study was to define risk factors related to pain in adult end-stage renal disease (ESRD) patients on chronic intermittent hemodialysis (HD) by developing a systematic review of published data. METHODS: The search was conducted from MEDLINE, Scopus, PsycINFO, and the Cumulative Index to Nursing and Allied Health Literature (CINAHL). Manuscripts in all languages were considered. Two authors performed each step independently, and all disagreements were resolved after discussion with the third author...
April 18, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28419501/stakeholders-views-of-the-introduction-of-assistive-technology-in-the-classroom-how-family-centred-is-australian-practice-for-students-with-cerebral-palsy
#17
P Karlsson, C Johnston, K Barker
BACKGROUND: With family-centred care widely recognized as a cornerstone for effective assistive technology service provision, the current study was undertaken to investigate to what extent such approaches were used by schools when assistive technology assessments and implementation occurred in the classroom. METHOD: In this cross-sectional study, we compare survey results from parents (n = 76), school staff (n = 33) and allied health professionals (n = 65) with experience in the use of high-tech assistive technology...
April 17, 2017: Child: Care, Health and Development
https://www.readbyqxmd.com/read/28418780/unique-phylogenetic-position-of-the-african-truffle-like-fungus-octaviania-ivoryana-boletaceae-boletales-and-the-proposal-of-a-new-genus-afrocastellanoa
#18
Takamichi Orihara, Matthew E Smith
The sequestrate (truffle-like) basidiomycete Octaviania ivoryana was originally described based on collections from Zimbabwe, Kenya, Guinea, and Senegal. This species has basidiomes that stain blue-green and basidiospores with crowded spines that are characteristic of the genus Octaviania. However, O. ivoryana is the only Octaviania species described from sub-Saharan Africa, and the phylogenetic relationship of the species to other species of Octaviania sensu stricto has not been previously investigated. We examined the phylogenetic position of the isotype and paratype specimens of O...
March 7, 2017: Mycologia
https://www.readbyqxmd.com/read/28417159/endangered-mangroves-in-segara-anakan-indonesia-effective-and-failed-problem-solving-policy-advice
#19
Budi Dharmawan, Michael Böcher, Max Krott
The success of scientific knowledge transfer depends on if the decision maker can transform the scientific advice into a policy that can be accepted by all involved actors. We use a science-policy interactions model called research-integration-utilization to observe the process of scientific knowledge transfer in the case of endangered mangroves in Segara Anakan, Indonesia. Scientific knowledge is produced within the scientific system (research), science-based solutions to problems are practically utilized by political actors (utilization), and important links between research and utilization must be made (integration)...
April 17, 2017: Environmental Management
https://www.readbyqxmd.com/read/28416011/which-learning-activities-enhance-physiotherapy-practice-a-systematic-review-protocol-of-quantitative-and-qualitative-studies
#20
Edmund Leahy, Lucy Chipchase, Felicity Blackstock
BACKGROUND: Learning activities are fundamental for the development of expertise in physiotherapy practice. Continuing professional development (CPD) encompasses formal and informal learning activities undertaken by physiotherapists. Identifying the most efficient and effective learning activities is essential to enable the profession to assimilate research findings and improve clinical skills to ensure the most efficacious care for clients. To date, systematic reviews on the effectiveness of CPD provide limited guidance on the most efficacious models of professional development for physiotherapists...
April 17, 2017: Systematic Reviews
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