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Heart tranplant

Lauren B Cooper, Carmelo A Milano, Melissa Williams, Wendy Swafford, Donna Croezen, Adrian B Van Bakel, Joseph G Rogers, Chetan B Patel
BACKGROUND: Acute hypothyroidism after brain death results in hemodynamic impairments that limit availability of donor hearts. Thyroid hormone infusions can halt that process and lead to increased utilization of donor organs, but prolonged use of thyroid replacement has not been well studied. METHODS: We developed a 15-question survey regarding policies, procedures, and reporting of thyroid hormone use by organ procurement organizations (OPOs). The survey was posted for 5 weeks on the Association of OPOs Portal...
December 2016: Clinical Transplantation
Thomas Cognet, Olivier Lairez, Pauline Marchal, Jérôme Roncalli, Michel Galinier
Myocarditis can lead to acute heart failure, cardiogenic shock, or sudden death and later, dilated cardiomyopathy (DCM) with chronic heart failure. We report the cases of two DCM induced by acute and past myocarditis in the same family and expressed by its two main complications within few weeks: an hemodynamic presentation as a fulminant myocarditis rapidly leading to cardiac tranplantation and a rythmologic presentation as an electrical storm leading to catheter ablation of ventricular tachycardia. These cases ask the question of the family predisposition to viral myocarditis leading to DCM...
2012: Case Reports in Cardiology
A V Kristen, H A Katus, Th J Dengler
Heart transplantation is the most effective treatment option for patients with end-stage heart failure to improve exercise tolerance and quality of life. This increase in quality of life may assume that heart transplant recipients are also able to return to their work. In general, there are no medical reasons to oppose a return to work. Despite enormous advances in medical rehabilitation after heart transplantation, the rate of working people among heart transplant recipients is very low. According to a survey at the Heidelberg Heart Transplant Center, only 37% of the heart transplant recipients return to work...
June 1, 2010: Versicherungsmedizin
Xiaojun Cui, Haijie Wang, Haidong Guo, Cun Wang, Hong Ao, Xiaoqin Liu, Yu-zhen Tan
Myocardial infarction (MI) causes myocardium injury and scar formation, and the transmural infarction is associated with ventricular hypofunction. Stem cell transplantation therapy has improved cardiac function in animal models of MI. However, the poor survival of the donor cells in the host myocardium hampers the therapeutic efficacy of stem cell transplantation. Diazoxide, a mitochondrial ATP-sensitive potassium channel opener, has been applied to suppress cell apoptosis and promote cell survival. We therefore assessed the effects of diazoxide on the selected mesenchymal stem cells (SMSCs)...
February 2010: Tohoku Journal of Experimental Medicine
Milivoje Vuković, Nebojsa Moljević, Zoran Milosević, Nenad Katanić, Dragan Krivokuća
INTRODUCTION: Liver transplantation is the most demanding of all solid organ tranplantations. It requires perfect organization and motivation of health care professionals, patients and their families. This article deals with the procedure for multiple organ procurement, reviews criteria for organ donation and describes the surgical tehnique for multiple organ procurement. DISCUSSION: Adequate selection and evaluation of cadaveric donors and of organs for transplantation should include early identification of potential donors, and early diagnosis of brain death...
July 2007: Medicinski Pregled
Behrooz Broumand
Iran is a tropical country with a land area of 1,648,000 square kilometers and a population of 68,100,000. Iran has a recorded history that dates back 2553 years. Its earliest medical school was Pasargad. Jondi Chapour University was founded 1753 years ago during the Sassanid dynasty as a center for higher education in medicine, philosophy, and pharmacology. Indeed, the idea of xenotransplantation dates back to days of Achaemenidae (Achaemenian dynasty), as evidenced by engravings of many mythologic chimeras still present in Persepolis...
June 2005: Experimental and Clinical Transplantation
Gaia Magnani, Elena Falchetti, Gianmatteo Pollini, Letizia Bacchi Reggiani, Francesco Grigioni, Fabio Coccolo, Luciano Potena, Carlo Magelli, Vittorio Sambri, Angelo Branzi
BACKGROUND: Influenza may cause severe disease in immunosuppressed patients. Different vaccines have been proved to be efficacious to prevent influenza in tranplant recipients. Since the last five years the addition of adjuvants to improve the immune response to vaccine preparations has been proposed and evaluated. In this study, two antigenically identical vaccines, but different for the presence of adjuvants were randomised among a cohort of heart transplant recipients to evaluate their safety and immunogenicity...
May 2005: Journal of Heart and Lung Transplantation
B Malassagne, J M Regimbeau, F Taboit, F Troalen, C Chéreau, N Moiré, J Attal, F Batteux, F Conti, Y Calmus, D Houssin, C Boulard, L M Houdebine, B Weill
BACKGROUND: Hyperacute rejection (HAR) of discordant xenografts in the pig-to-human combination can be prevented using tranplants expressing transgenic molecules that inhibit human complement. Hypodermin A (HA), a serine esterase that degrades C3, was tested in the guinea-pig-to-rat and in the pig-to-human combinations. METHODS: Hypodermin A was tested in vitro, ex vivo, and in vivo models of HAR in the guinea-pig-to-rat combination. Hamster ovary cells (CHO) and a line of porcine aortic endothelial cells (PAEC11) were transfected with HA complementary DNA (cDNA)...
May 2003: Xenotransplantation
Hillel Laks, Daniel Marelli, Gregg C Fonarow, Michele A Hamilton, Abbas Ardehali, Jaime D Moriguchi, Jessica Bresson, David Gjertson, Jon A Kobashigawa
OBJECTIVE: An alternate (second) adult recipient list was used to match excluded potential recipients with nonstandard donor hearts that would otherwise be unused. METHODS: The only absolute criterion for entering the alternate recipient list was age: 65 years old before 1998 and 70 years old after that. Group I consisted of alternates who underwent transplantation, and group II consisted of 401 contemporaneous recipients. Hearts were first offered to regularly listed patients...
January 2003: Journal of Thoracic and Cardiovascular Surgery
T E Starzl, N Murase, A Demetris, M Trucco, J Fung
The evolution of clinical transplantation has hinged on 2 seminal turning points. The first was the demonstration in 1953 by Billingham, Brent, and Medawar that chimerism-associated tolerance could be induced deliberately in neonatal mice by infusing adult donor hematolymphopoietic cells. This discovery escalated in a straight line over the next 15 years to successful bone marrow transplantation in humans. The second turning point was the demonstration that organ allografts could self-induce tolerance under an umbrella of immunosuppression, or in some species without immunosuppression...
2000: Seminars in Liver Disease
M Schwaiblmair, H Reichenspurner, C Müller, J Briegel, H Fürst, J Groh, B Reichart, C Vogelmeier
Heart-lung (HLT) and lung transplantation (LT) have been shown to be effective procedures for patients with end-stage cardiopulmonary disorders. As yet, few data exist on the exercise performance of patients before and after thoracic transplantation except with regard to 6-min walk tests. In this article we report cardiopulmonary exercise test results of lung and heart-lung transplant recipients in comparison with their pretransplant values. We studied 103 consecutive recipients of single-lung (n = 46), bilateral lung (n = 32), and heart-lung (n = 25) transplants...
April 1999: American Journal of Respiratory and Critical Care Medicine
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