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Cognition and functional connectivity

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https://www.readbyqxmd.com/read/28213119/the-heterogeneity-of-the-left-dorsal-premotor-cortex-evidenced-by-multimodal-connectivity-based-parcellation-and-functional-characterization
#1
Sarah Genon, Andrew Reid, Hai Li, Lingzhong Fan, Veronika I Müller, Edna C Cieslik, Felix Hoffstaedter, Robert Langner, Christian Grefkes, Angela R Laird, Peter T Fox, Tianzi Jiang, Katrin Amunts, Simon B Eickhoff
Despite the common conception of the dorsal premotor cortex (PMd) as a single brain region, its diverse connectivity profiles and behavioral heterogeneity argue for a differentiated organization of the PMd. A previous study revealed that the right PMd is characterized by a rostro-caudal and a ventro-dorsal distinction dividing it into five subregions: rostral, central, caudal, ventral and dorsal. The present study assessed whether a similar organization is present in the left hemisphere, by capitalizing on a multimodal data-driven approach combining connectivity-based parcellation (CBP) based on meta-analytic modeling, resting-state functional connectivity, and probabilistic diffusion tractography...
February 14, 2017: NeuroImage
https://www.readbyqxmd.com/read/28212570/altered-amygdala-and-hippocampus-effective-connectivity-in-mild-cognitive-impairment-patients-with-depression-a-resting-state-functional-mr-imaging-study-with-granger-causality-analysis
#2
Li Juan Zheng, Gui Fen Yang, Xin Yuan Zhang, Yun Fei Wang, Ya Liu, Gang Zheng, Guang Ming Lu, Long Jiang Zhang, Ying Han
Neuroimaging studies have demonstrated that the major depression disorder would increase the risk of dementia in the older with amnestic cognitive impairment. We used granger causality analysis algorithm to explore the amygdala- and hippocampus-based directional connectivity patterns in 12 patients with major depression disorder and amnestic cognitive impairment (mean age: 69.5 ± 10.3 years), 13 amnestic cognitive impairment patients (mean age: 72.7 ± 8.5 years) and 14 healthy controls (mean age: 64.7 ± 7...
February 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28212278/the-effect-of-the-human-peptide-ghk-on-gene-expression-relevant-to-nervous-system-function-and-cognitive-decline
#3
Loren Pickart, Jessica Michelle Vasquez-Soltero, Anna Margolina
Neurodegeneration, the progressive death of neurons, loss of brain function, and cognitive decline is an increasing problem for senior populations. Its causes are poorly understood and therapies are largely ineffective. Neurons, with high energy and oxygen requirements, are especially vulnerable to detrimental factors, including age-related dysregulation of biochemical pathways caused by altered expression of multiple genes. GHK (glycyl-l-histidyl-l-lysine) is a human copper-binding peptide with biological actions that appear to counter aging-associated diseases and conditions...
February 15, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28211789/the-cortical-connectivity-of-the-periaqueductal-gray-and-the-conditioned-response-to-the-threat-of-breathlessness
#4
Olivia K Faull, Kyle Ts Pattinson
Previously we observed differential activation in individual columns of the periaqueductal grey (PAG) during breathlessness and its conditioned anticipation (Faull et al., 2016). Here, we have extended this work by determining how the individual columns of the PAG interact with higher cortical centres, both at rest and in the context of breathlessness threat. Activation was observed in ventrolateral PAG (vlPAG) and lateral PAG (lPAG), where activity scaled with breathlessness intensity ratings, revealing a potential interface between sensation and cognition during breathlessness...
February 17, 2017: ELife
https://www.readbyqxmd.com/read/28211449/translational-use-of-event-related-potentials-to-assess-circuit-integrity-in-asd
#5
REVIEW
Meera E Modi, Mustafa Sahin
Deficits in social cognition are the defining characteristic of autism spectrum disorder (ASD). Social cognition requires the integration of several neural circuits in a time-sensitive fashion, so impairments in social interactions could arise as a result of alterations in network connectivity. Electroencephalography (EEG) has revealed abnormalities in event related potentials (ERPs) evoked by auditory and visual sensory stimuli in humans with ASD, indicating disruption of neural connectivity. Similar abnormalities in sensory-evoked ERPs have been observed in animal models of ASD, suggesting that ERPs have the potential to provide a translational biomarker of the disorder...
February 17, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28210978/future-directions-in-imaging-neurodegeneration
#6
REVIEW
Joseph C Masdeu
Neuroimaging comprises a powerful set of instruments to diagnose various neurodegenerative disorders, clarifies their neurobiology, and monitors their treatment. Magnetic resonance imaging depicts volume changes, as well as abnormalities in functional and structural connectivity. Positron emission tomography (PET) allows for the quantification of regional cerebral metabolism, characteristically altered in Alzheimer's disease, amyotrophic lateral sclerosis, diffuse Lewy-body disease, and the frontotemporal dementias...
January 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28210848/prefrontal-hippocampal-coupling-by-theta-rhythm-and-by-2-5%C3%A2-hz-oscillation-in-the-delta-band-the-role-of-the-nucleus-reuniens-of-the-thalamus
#7
Alexis Roy, Frans Pettersson Svensson, Amna Mazeh, Bernat Kocsis
Rhythmic synchronizations of hippocampus (HC) and prefrontal cortex (PFC) at theta frequencies (4-8 Hz) are thought to mediate key cognitive functions, and disruptions of HC-PFC coupling were implicated in psychiatric diseases. Theta coupling is thought to represent a HC-to-PFC drive transmitted via the well-described unidirectional HC projection to PFC. In comparison, communication in the PFC-to-HC direction is less understood, partly because no known direct anatomical connection exists. Two recent findings, i...
February 16, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28209266/changes-in-functional-organization-and-functional-connectivity-during-story-listening-in-children-with-benign-childhood-epilepsy-with-centro-temporal-spikes
#8
Jennifer Vannest, Thomas C Maloney, Jeffrey R Tenney, Jerzy P Szaflarski, Diego Morita, Anna W Byars, Mekibib Altaye, Scott K Holland, Tracy A Glauser
Children with Benign Epilepsy with Centrotemporal Spikes (BECTS), despite high likelihood for seizure remission, are reported to have subtle difficulties in language and other cognitive skills. We used functional MRI and a story listening task to examine the effect of BECTS on patterns of activation and connectivity. Language and cognitive skills were assessed using standardized measures. Twenty-four children with recently diagnosed BECTS and 40 typically-developing children participated. In a functionally-defined region of interest in right inferior frontal gyrus, BECTS patients showed a lower level of activation...
February 13, 2017: Brain and Language
https://www.readbyqxmd.com/read/28208070/association-of-medial-prefrontal-resting-state-functional-connectivity-and-metacognitive-capacity-in-early-phase-psychosis
#9
Michael M Francis, Tom A Hummer, Bethany L Leonhardt, Jenifer L Vohs, Matt G Yung, Nicole F Mehdiyoun, Paul H Lysaker, Alan Breier
Metacognition refers to a range of cognitive processes that allow one to form complex ideas of self and others and to use this information to navigate psychosocial challenges. Several studies in both early-phase and prolonged schizophrenia have demonstrated not only that significant deficits in metacognitive ability are present, but importantly that they are associated with significant functional impairment and decreased quality of life. In spite of the importance of metacognitive impairment in schizophrenia, relatively little is known about the biological substrates that may contribute to this dysfunction...
February 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28205364/altered-neural-mechanisms-of-cognitive-control-in-patients-with-primary-progressive-multiple-sclerosis-an-effective-connectivity-study
#10
Ekaterina Dobryakova, Maria Assunta Rocca, Paola Valsasina, John DeLuca, Massimo Filippi
Primary progressive multiple sclerosis (PPMS) leads to physical and cognitive disability. Specifically, cognitive deficits in PPMS have been explained by both grey matter atrophy and white matter lesions. However, existing research still lacks in the understanding of how the brain of a patient with PPMS functions under cognitive control demands. Thus, the aim of the current study was to examine information integration in patients with PPMS using a search-based effective connectivity method. Fourteen patients with PPMS and 22 age- and gender-matched healthy controls (HC) performed the Stroop task, a cognitively demanding interference task that taxes neural resources required for cognitive control and response inhibition...
February 16, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28205157/a-conceptual-neurocognitive-affect-related-model-for-the-promotion-of-exercise-among-obese-adults
#11
REVIEW
Meghan K Edwards, Ovuokerie Addoh, Skyla M Herod, Ryan E Rhodes, Paul D Loprinzi
PURPOSE OF REVIEW: Obesity remains a prominent societal threat and burden despite well-promoted prevention and treatment strategies, such as regular engagement in physical activity. Obese individuals, in particular, may be prone to inactivity as a result of a variety of displeasure-related parameters resulting from exercise, such as dyspnea, for instance. RECENT FINDINGS: This brief conceptual review discusses the integral roles of exercise-induced affective responses within a novel conceptual-based neurocognitive affect-related model...
February 16, 2017: Current Obesity Reports
https://www.readbyqxmd.com/read/28202336/functional-connectivity-in-resting-state-as-a-phonemic-fluency-ability-measure
#12
Anna Miró-Padilla, Elisenda Bueichekú, Noelia Ventura-Campos, María-Ángeles Palomar-García, César Ávila
There is some evidence that functional connectivity (FC) measures obtained at rest may reflect individual differences in cognitive capabilities. We tested this possibility by using the FAS test as a measure of phonemic fluency. Seed regions of the main brain areas involved in this task were extracted from meta-analysis results (Wagner et al., 2014) and used for pairwise resting-state FC analysis. Ninety-three undergraduates completed the FAS test outside the scanner. A correlation analysis was conducted between the F-A-S scores (behavioral testing) and the pairwise FC pattern of verbal fluency regions of interest...
February 12, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28198813/increased-anterior-cingulate-cortex-response-precedes-behavioural-adaptation-in-anorexia-nervosa
#13
Daniel Geisler, Franziska Ritschel, Joseph A King, Fabio Bernardoni, Maria Seidel, Ilka Boehm, Franziska Runge, Thomas Goschke, Veit Roessner, Michael N Smolka, Stefan Ehrlich
Patients with anorexia nervosa (AN) are characterised by increased self-control, cognitive rigidity and impairments in set-shifting, but the underlying neural mechanisms are poorly understood. Here we used functional magnetic resonance imaging (fMRI) to elucidate the neural correlates of behavioural adaptation to changes in reward contingencies in young acutely ill AN patients. Thirty-six adolescent/young adult, non-chronic female AN patients and 36 age-matched healthy females completed a well-established probabilistic reversal learning task during fMRI...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28198067/verbal-spatial-iq-discrepancies-impact-brain-activation-associated-with-the-resolution-of-cognitive-conflict-in-children-and-adolescents
#14
Amy E Margolis, Katie S Davis, Lisa S Pao, Amy Lewis, Xiao Yang, Gregory Tau, Guihu Zhao, Zhishun Wang, Rachel Marsh
Verbal-spatial discrepancies are common in healthy individuals and in those with neurodevelopmental disorders associated with cognitive control deficits including: Autism Spectrum Disorder, Non-Verbal Learning Disability, Fragile X, 22q11 deletion, and Turner Syndrome. Previous data from healthy individuals suggest that the magnitude of the difference between verbal IQ (VIQ) and performance IQ (PIQ) scores (the VIQ>PIQ discrepancy) is associated with reduced thickness in frontal and parietal cortices (inferior frontal, anterior cingulate, inferior parietal lobule, and supramarginal gyrus) that support cognitive control...
February 15, 2017: Developmental Science
https://www.readbyqxmd.com/read/28195569/rare-damaging-variants-in-dna-repair-and-cell-cycle-pathways-are-associated-with-hippocampal-and-cognitive-dysfunction-a-combined-genetic-imaging-study-in-first-episode-treatment-naive-patients-with-schizophrenia
#15
Z Yang, M Li, X Hu, B Xiang, W Deng, Q Wang, Y Wang, L Zhao, X Ma, P C Sham, G Northoff, T Li
Schizophrenia is a complex neurodevelopmental disorder where changes in both hippocampus and memory-related cognitive functions are central. However, the exact relationship between neurodevelopmental-genetic factors and hippocampal-cognitive dysfunction remains unclear. The general aim of our study is to link the occurrence of rare damaging mutations involved in susceptibility gene pathways to the structure and function of hippocampus in order to define genetically and phenotypically based subgroups in schizophrenia...
February 14, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28195438/from-rest-to-language-task-task-activation-selects-and-prunes-from-broader-resting-state-network
#16
Gaelle E Doucet, Xiaosong He, Michael R Sperling, Ashwini Sharan, Joseph I Tracy
Resting-state networks (RSNs) show spatial patterns generally consistent with networks revealed during cognitive tasks. However, the exact degree of overlap between these networks has not been clearly quantified. Such an investigation shows promise for decoding altered functional connectivity (FC) related to abnormal language functioning in clinical populations such as temporal lobe epilepsy (TLE). In this context, we investigated the network configurations during a language task and during resting state using FC...
February 14, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28193691/optogenetic-examination-of-prefrontal-amygdala-synaptic-development
#17
Maithe Arruda-Carvalho, Wan-Chen Wu, Kirstie A Cummings, Roger L Clem
A brain network comprising the medial prefrontal cortex (mPFC) and amygdala plays important roles in developmentally-regulated cognitive and emotional processes. However, very little is known about the maturation of mPFC-amygdala circuitry. We conducted anatomical tracing of mPFC projections and optogenetic interrogation of their synaptic connections with neurons in the basolateral amygdala (BLA) at neonatal to adult developmental stages in mice. Results indicate that mPFC-BLA projections exhibit delayed emergence relative to other mPFC pathways and establish synaptic transmission with BLA excitatory and inhibitory neurons in late infancy, events which coincide with a massive increase in overall synaptic drive...
February 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28193685/neurocomputational-consequences-of-evolutionary-connectivity-changes-in-perisylvian-language-cortex
#18
Malte R Schomers, Max Garagnani, Friedemann Pulvermüller
The human brain sets itself apart from that of its primate relatives by specific neuroanatomical features, especially the strong linkage of left perisylvian language areas (frontal and temporal cortex) by way of the arcuate fasciculus (AF). AF connectivity has been shown to correlate with verbal working memory (VWM) - a specifically human trait providing the foundation for language abilities - but a mechanistic explanation of any related causal link between anatomical structure and cognitive function is still missing...
February 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28192723/influence-of-age-and-cognitive-performance-on-resting-state-brain-networks-of-older-adults-in-a-population-based-cohort
#19
Christiane Jockwitz, Svenja Caspers, Silke Lux, Simon B Eickhoff, Kerstin Jütten, Stefan Lenzen, Susanne Moebus, Noreen Pundt, Andrew Reid, Felix Hoffstaedter, Karl-Heinz Jöckel, Raimund Erbel, Sven Cichon, Markus M Nöthen, N Jon Shah, Karl Zilles, Katrin Amunts
Aging leads to global changes in brain structure and cognitive performance, with reorganization of functional brain networks. Importantly, these age-related changes show higher inter-individual variability in older subjects. To particularly address this variability is a challenge for studies on lifetime trajectories from early to late adulthood. The present study therefore had a dedicated focus on late adulthood to characterize the functional connectivity in resting-state networks (RSFC) in relation to age and cognitive performance in 711 older adults (55-85 years) from the 1000BRAINS project...
January 23, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28192177/neural-mechanisms-of-implicit-cognitive-reappraisal-preceding-descriptions-alter-emotional-response-to-unpleasant-images
#20
Hai-Yang Wang, Guo-Qing Xu, Ming-Fei Ni, Cui-Hong Zhang, Xiao-Pei Sun, Yi Chang, Bing-Wei Zhang
The importance of reappraising negative events to reduce negative emotional responses has been widely acknowledged. However, most neuroimaging studies have explored the neural mechanisms of deliberate and intentional reappraisal, while little is known about the neural correlates of reappraisal that occurs outside of one's awareness. Electrophysiological studies suggest that precedent neutral descriptions could implicitly reduce neural responses to unpleasant images. To investigate the neural mechanism underlying implicit reappraisal, functional magnetic resonance imaging was conducted on 25 participants while they passively viewed unpleasant images that were previously neutrally/positively or negatively described...
February 9, 2017: Neuroscience
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