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Sean J. Morrison

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https://www.readbyqxmd.com/read/28213060/prediction-of-cesarean-delivery-in-the-term-nulliparous-woman-results-from-the-prospective-multi-center-genesis-study
#1
Naomi Burke, Gerard Burke, Fionnuala Breathnach, Fionnuala Mcauliffe, John J Morrison, Michael Turner, Samina Dornan, John R Higgins, Amanda Cotter, Michael Geary, Peter Mcparland, Sean Daly, Fiona Cody, Pat Dicker, Elizabeth Tully, Fergal D Malone
BACKGROUND: In contemporary practice many nulliparous women require intervention during childbirth such as operative vaginal delivery or Cesarean delivery (CD). Despite the knowledge that the rising CD rate is associated with increasing maternal age, obesity and larger infant birthweight, we lack a reliable method to predict the requirement for such potentially hazardous obstetric procedures during labor and delivery. This issue is important as there are higher rates of morbidity and mortality associated with unplanned CD performed in labor compared to scheduled Cesarean deliveries...
February 14, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28156192/cost-analysis-of-a-prospective-multi-site-cohort-study-of-palliative-care-consultation-teams-for-adults-with-advanced-cancer-where-do-cost-savings-come-from
#2
Peter May, Melissa M Garrido, J Brian Cassel, Amy S Kelley, Diane E Meier, Charles Normand, Thomas J Smith, R Sean Morrison
BACKGROUND: Studies report cost-savings from hospital-based palliative care consultation teams compared to usual care only, but drivers of observed differences are unclear. AIM: To analyse cost-differences associated with palliative care consultation teams using two research questions: (Q1) What is the association between early palliative care consultation team intervention, and intensity of services and length of stay, compared to usual care only? (Q2) What is the association between early palliative care consultation team intervention and day-to-day hospital costs, compared to a later intervention? DESIGN: Prospective multi-site cohort study (2007-2011)...
February 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/28122244/distinct-brca1-mutations-differentially-reduce-hematopoietic-stem-cell-function
#3
Victoria E Mgbemena, Robert A J Signer, Ranjula Wijayatunge, Travis Laxson, Sean J Morrison, Theodora S Ross
BRCA1 is a well-known DNA repair pathway component and a tissue-specific tumor suppressor. However, its role in hematopoiesis is uncertain. Here, we report that a cohort of patients heterozygous for BRCA1 mutations experienced more hematopoietic toxicity from chemotherapy than those with BRCA2 mutations. To test whether this reflects a requirement for BRCA1 in hematopoiesis, we generated mice with Brca1 mutations in hematopoietic cells. Mice homozygous for a null Brca1 mutation in the embryonic hematopoietic system (Vav1-iCre;Brca1(F22-24/F22-24)) developed hematopoietic defects in early adulthood that included reduced hematopoietic stem cells (HSCs)...
January 24, 2017: Cell Reports
https://www.readbyqxmd.com/read/28052317/prenatal-prediction-of-significant-intertwin-birth-weight-discordance-using-standard-second-and-third-trimester-sonographic-parameters
#4
Mark P Hehir, Fionnuala M Breathnach, Jennifer L Hogan, Fionnuala M McAuliffe, Michael P Geary, Sean Daly, John Higgins, Alyson Hunter, John J Morrison, Gerard Burke, Rhona Mahony, Patrick Dicker, Elizabeth Tully, Fergal D Malone
INTRODUCTION: To evaluate standard ultrasound-derived fetal biometric parameters in the prediction of clinically significant intertwin birthweight discordance defined as ≥18%. MATERIAL AND METHODS: This was a secondary analysis of a prospective cohort study of 1,028 unselected twin pairs recruited over a two year period. Dichorionic twins underwent two-weekly ultrasonographic surveillance from 24 weeks' gestation, with surveillance of monochorionic twins two-weekly from 16 weeks...
January 4, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28006086/recurrent-oral-cavity-cancer-patterns-of-failure-after-salvage-multimodality-therapy
#5
Sean R Quinlan-Davidson, William H Morrison, Jeffrey N Myers, Gary B Gunn, William N William, Beth M Beadle, Heath D Skinner, Ann M Gillenwater, Steven J Frank, Jack Phan, Faye M Johnson, Clifton D Fuller, Mark E Zafereo, David I Rosenthal, Adam S Garden
BACKGROUND: We focused on a cohort of radiation naïve patients who had recurrent oral cavity cancer (recurrent OCC) to assess their outcomes with salvage multimodal therapy. METHODS: A retrospective single institutional study was performed of patients with recurrent OCC. Disease recurrence and survival outcomes were assessed. RESULTS: Seventy-eight patients were analyzed. All patients had salvage surgery and intensity-modulated radiotherapy (IMRT) and 74% had chemotherapy...
December 22, 2016: Head & Neck
https://www.readbyqxmd.com/read/27988273/the-association-of-maximum-troponin-values-post-out-of-hospital-cardiac-arrest-with-electrocardiographic-findings-cardiac-reperfusion-procedures-and-survival-to-discharge-a-sub-study-of-roc-primed
#6
Laurie J Morrison, Sean M Devlin, Michael C Kontos, Sheldon Cheskes, Tom P Aufderheide, Jim Christenson, Joseph P Ornato, Ian G Stiell, Valeria E Rac, Andrew J Thomas, Jane G Wigginton, Paul Dorian
BACKGROUND: The role of Troponin (Tn) levels in the management of patients post out-of-hospital cardiac arrest (OHCA) is unclear. METHODS: All OHCA patients enrolled in the Resuscitation Outcomes Consortium Prehospital Resuscitation using an IMpedance valve and Early versus Delayed analysis trial and admitted to hospital with a Tn level and a 12-lead electrocardiogram were stratified by ST elevation (STE) or no STE in a regression model for survival to discharge adjusted for Utstein predictors and site...
February 2017: Resuscitation
https://www.readbyqxmd.com/read/27976999/clec11a-osteolectin-is-an-osteogenic-growth-factor-that-promotes-the-maintenance-of-the-adult-skeleton
#7
Rui Yue, Bo Shen, Sean J Morrison
Bone marrow stromal cells maintain the adult skeleton by forming osteoblasts throughout life that regenerate bone and repair fractures. We discovered that subsets of these stromal cells, osteoblasts, osteocytes, and hypertrophic chondrocytes secrete a C-type lectin domain protein, Clec11a, which promotes osteogenesis. Clec11a-deficient mice appeared developmentally normal and had normal hematopoiesis but reduced limb and vertebral bone. Clec11a-deficient mice exhibited accelerated bone loss during aging, reduced bone strength, and delayed fracture healing...
December 13, 2016: ELife
https://www.readbyqxmd.com/read/27919080/corrigendum-lens-regeneration-using-endogenous-stem-cells-with-gain-of-visual-function
#8
Haotian Lin, Hong Ouyang, Jie Zhu, Shan Huang, Zhenzhen Liu, Shuyi Chen, Guiqun Cao, Gen Li, Robert A J Signer, Yanxin Xu, Christopher Chung, Ying Zhang, Danni Lin, Sherrina Patel, Frances Wu, Huimin Cai, Jiayi Hou, Cindy Wen, Maryam Jafari, Xialin Liu, Lixia Luo, Jin Zhu, Austin Qiu, Rui Hou, Baoxin Chen, Jiangna Chen, David Granet, Christopher Heichel, Fu Shang, Xuri Li, Michal Krawczyk, Dorota Skowronska-Krawczyk, Yujuan Wang, William Shi, Daniel Chen, Zheng Zhong, Sheng Zhong, Liangfang Zhang, Shaochen Chen, Sean J Morrison, Richard L Maas, Kang Zhang, Yizhi Liu
No abstract text is available yet for this article.
January 26, 2017: Nature
https://www.readbyqxmd.com/read/27810850/how-empowering-is-hospital-care-for-older-people-with-advanced-disease-barriers-and-facilitators-from-a-cross-national-ethnography-in-england-ireland-and-the-usa
#9
Lucy Ellen Selman, Barbara A Daveson, Melinda Smith, Bridget Johnston, Karen Ryan, R Sean Morrison, Caty Pannell, Regina McQuillan, Suzanne de Wolf-Linder, Steven Z Pantilat, Lara Klass, Diane Meier, Charles Normand, Irene J Higginson
BACKGROUND: patient empowerment, through which patients become self-determining agents with some control over their health and healthcare, is a common theme across health policies globally. Most care for older people is in the acute setting, but there is little evidence to inform the delivery of empowering hospital care. OBJECTIVE: we aimed to explore challenges to and facilitators of empowerment among older people with advanced disease in hospital, and the impact of palliative care...
November 3, 2016: Age and Ageing
https://www.readbyqxmd.com/read/27787895/regional-nerve-blocks-improve-pain-and-functional-outcomes-in-hip-fracture-a-randomized-controlled-trial
#10
R Sean Morrison, Eitan Dickman, Ula Hwang, Saadia Akhtar, Taja Ferguson, Jennifer Huang, Christina L Jeng, Bret P Nelson, Meg A Rosenblatt, Jeffrey H Silverstein, Reuben J Strayer, Toni M Torrillo, Knox H Todd
OBJECTIVES: To compared outcomes of regional nerve blocks with those of standard analgesics after hip fracture. DESIGN: Multisite randomized controlled trial from April 2009 to March 2013. SETTING: Three New York hospitals. PARTICIPANTS: Individuals with hip fracture (N = 161). INTERVENTION: Participants were randomized to receive an ultrasound-guided, single-injection, femoral nerve block administered by emergency physicians at emergency department (ED) admission followed by placement of a continuous fascia iliaca block by anesthesiologists within 24 hours (n = 79) or conventional analgesics (n = 82)...
December 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27681157/erratum-synergistic-effects-of-ion-transporter-and-map-kinase-pathway-inhibitors-in-melanoma
#11
Ugur Eskiocak, Vijayashree Ramesh, Jennifer G Gill, Zhiyu Zhao, Stacy W Yuan, Meng Wang, Travis Vandergriff, Mark Shackleton, Elsa Quintana, Arthur E Frankel, Timothy M Johnson, Ralph J DeBerardinis, Sean J Morrison
No abstract text is available yet for this article.
2016: Nature Communications
https://www.readbyqxmd.com/read/27670948/denial-of-long-term-issues-with-agriculture-on-tropical-peatlands-will-have-devastating-consequences
#12
LETTER
Lahiru S Wijedasa, Jyrki Jauhiainen, Mari Könönen, Maija Lampela, Harri Vasander, Marie-Claire Leblanc, Stephanie Evers, Thomas E L Smith, Catherine M Yule, Helena Varkkey, Massimo Lupascu, Faizal Parish, Ian Singleton, Gopalasamy R Clements, Sheema Abdul Aziz, Mark E Harrison, Susan Cheyne, Gusti Z Anshari, Erik Meijaard, Jenny E Goldstein, Susan Waldron, Kristell Hergoualc'h, Rene Dommain, Steve Frolking, Christopher D Evans, Mary Rose C Posa, Paul H Glaser, Nyoman Suryadiputra, Reza Lubis, Truly Santika, Rory Padfield, Sofyan Kurnianto, Panut Hadisiswoyo, Teck Wyn Lim, Susan E Page, Vincent Gauci, Peter J Van Der Meer, Helen Buckland, Fabien Garnier, Marshall K Samuel, Liza Nuriati Lim Kim Choo, Patrick O'Reilly, Matthew Warren, Surin Suksuwan, Elham Sumarga, Anuj Jain, William F Laurance, John Couwenberg, Hans Joosten, Ronald Vernimmen, Aljosja Hooijer, Chris Malins, Mark A Cochrane, Balu Perumal, Florian Siegert, Kelvin S-H Peh, Louis-Pierre Comeau, Louis Verchot, Charles F Harvey, Alex Cobb, Zeehan Jaafar, Henk Wösten, Solichin Manuri, Moritz Müller, Wim Giesen, Jacob Phelps, Ding Li Yong, Marcel Silvius, Béatrice M M Wedeux, Alison Hoyt, Mitsuru Osaki, Takashi Hirano, Hidenori Takahashi, Takashi S Kohyama, Akira Haraguchi, Nunung P Nugroho, David A Coomes, Le Phat Quoi, Alue Dohong, Haris Gunawan, David L A Gaveau, Andreas Langner, Felix K S Lim, David P Edwards, Xingli Giam, Guido Van Der Werf, Rachel Carmenta, Caspar C Verwer, Luke Gibson, Laure Gandois, Laura Linda Bozena Graham, Jhanson Regalino, Serge A Wich, Jack Rieley, Nicholas Kettridge, Chloe Brown, Romain Pirard, Sam Moore, B Ripoll Capilla, Uwe Ballhorn, Hua Chew Ho, Agata Hoscilo, Sandra Lohberger, Theodore A Evans, Nina Yulianti, Grace Blackham, Onrizal, Simon Husson, Daniel Murdiyarso, Sunita Pangala, Lydia E S Cole, Luca Tacconi, Hendrik Segah, Prayoto Tonoto, Janice S H Lee, Gerald Schmilewski, Stephan Wulffraat, Erianto Indra Putra, Megan E Cattau, R S Clymo, Ross Morrison, Aazani Mujahid, Jukka Miettinen, Soo Chin Liew, Samu Valpola, David Wilson, Laura D'Arcy, Michiel Gerding, Siti Sundari, Sara A Thornton, Barbara Kalisz, Stephen J Chapman, Ahmad Suhaizi Mat Su, Imam Basuki, Masayuki Itoh, Carl Traeholt, Sean Sloan, Alexander K Sayok, Roxane Andersen
No abstract text is available yet for this article.
September 27, 2016: Global Change Biology
https://www.readbyqxmd.com/read/27545456/synergistic-effects-of-ion-transporter-and-map-kinase-pathway-inhibitors-in-melanoma
#13
Ugur Eskiocak, Vijayashree Ramesh, Jennifer G Gill, Zhiyu Zhao, Stacy W Yuan, Meng Wang, Travis Vandergriff, Mark Shackleton, Elsa Quintana, Timothy M Johnson, Ralph J DeBerardinis, Sean J Morrison
New therapies are required for melanoma. Here, we report that multiple cardiac glycosides, including digitoxin and digoxin, are significantly more toxic to human melanoma cells than normal human cells. This reflects on-target inhibition of the ATP1A1 Na(+)/K(+) pump, which is highly expressed by melanoma. MEK inhibitor and/or BRAF inhibitor additively or synergistically combined with digitoxin to induce cell death, inhibiting growth of patient-derived melanomas in NSG mice and synergistically extending survival...
2016: Nature Communications
https://www.readbyqxmd.com/read/27492367/the-rate-of-protein-synthesis-in-hematopoietic-stem-cells-is-limited-partly-by-4e-bps
#14
Robert A J Signer, Le Qi, Zhiyu Zhao, David Thompson, Alla A Sigova, Zi Peng Fan, George N DeMartino, Richard A Young, Nahum Sonenberg, Sean J Morrison
Adult stem cells must limit their rate of protein synthesis, but the underlying mechanisms remain largely unexplored. Differences in protein synthesis among hematopoietic stem cells (HSCs) and progenitor cells did not correlate with differences in proteasome activity, total RNA content, mRNA content, or cell division rate. However, adult HSCs had more hypophosphorylated eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and 4E-BP2 as compared with most other hematopoietic progenitors. Deficiency for 4E-BP1 and 4E-BP2 significantly increased global protein synthesis in HSCs, but not in other hematopoietic progenitors, and impaired their reconstituting activity, identifying a mechanism that promotes HSC maintenance by attenuating protein synthesis...
August 1, 2016: Genes & Development
https://www.readbyqxmd.com/read/27364647/erratum-to-ultrasound-guided-nerve-blocks-for-intracapsular-and-extracapsular-hip-fractures-am-j-emerg-med-34-3-2016-586-589
#15
Eitan Dickman, Illya Pushkar, Antonios Likourezos, Knox Todd, Ula Hwang, Saadia Akhtar, Sean Morrison
No abstract text is available yet for this article.
May 25, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27302243/gestational-hypertensive-disease-in-twin-pregnancy-influence-on-outcomes-in-a-large-national-prospective-cohort
#16
Mark P Hehir, Fionnuala M Breathnach, Fionnuala M McAuliffe, Michael P Geary, Sean Daly, John Higgins, Alyson Hunter, John J Morrison, Gerard Burke, Shane Higgins, Rhona Mahony, Patrick Dicker, Elizabeth C Tully, Fergal D Malone
OBJECTIVE: Gestational hypertensive disease (GHD) is associated with pregnancy-related complications and poor maternal and fetal outcomes in singleton pregnancies. We sought to examine the influence of GHD in a large prospective cohort of twin pregnancies. STUDY DESIGN: The ESPRIT study was a national multicenter observational cohort study of 1028 structurally normal twin pregnancies. Each pregnancy underwent sonographic surveillance with two-week ultrasound from 24 weeks for dichorionic and from 16 weeks for monochorionic gestations...
October 2016: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27248056/impact-of-inpatient-palliative-care-on-treatment-intensity-for-patients-with-serious-illness
#17
Jay R Horton, R Sean Morrison, Elizabeth Capezuti, Jennifer Hill, Eric J Lee, Amy S Kelley
BACKGROUND: Palliative care is associated with decreased treatment intensity and improved quality for individual patients at the end of life, but little is known about how hospital-wide outcomes are affected by the diffusion of palliative care principles. OBJECTIVE: We examined the relationship between presence of palliative care programs and hospitals' average treatment intensity, as indicated by mean intensive care unit (ICU) length of stay (LOS) and days under Medicare hospice coverage, in the last six months of life among Medicare beneficiaries aged 67 and over with serious chronic illness...
September 2016: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/27053299/leptin-receptor-promotes-adipogenesis-and-reduces-osteogenesis-by-regulating-mesenchymal-stromal-cells-in-adult-bone-marrow
#18
Rui Yue, Bo O Zhou, Issei S Shimada, Zhiyu Zhao, Sean J Morrison
Skeletal stem cells (SSCs) that are the major source of osteoblasts and adipocytes in adult bone marrow express leptin receptor (LepR). To test whether LepR regulates SSC function, we conditionally deleted Lepr from limb bone marrow stromal cells, but not from the axial skeleton or hypothalamic neurons, using Prx1-Cre. Prx1-Cre;Lepr(fl/fl) mice exhibited normal body mass and normal hematopoiesis. However, limb bones from Prx1-Cre;Lepr(fl/fl) mice exhibited increased osteogenesis, decreased adipogenesis, and accelerated fracture healing...
June 2, 2016: Cell Stem Cell
https://www.readbyqxmd.com/read/26990009/identifying-older-adults-with-serious-illness-a-critical-step-toward-improving-the-value-of-health-care
#19
Amy S Kelley, Kenneth E Covinsky, Rebecca J Gorges, Karen McKendrick, Evan Bollens-Lund, R Sean Morrison, Christine S Ritchie
OBJECTIVE: To create and test three prospective, increasingly restrictive definitions of serious illness. DATA SOURCES: Health and Retirement Study, 2000-2012. STUDY DESIGN: We evaluated subjects' 1-year outcomes from the interview date when they first met each definition: (A) one or more severe medical conditions (Condition) and/or receiving assistance with activities of daily living (Functional Limitation); (B) Condition and/or Functional Limitation and hospital admission in the last 12 months and/or residing in a nursing home (Utilization); and (C) Condition and Functional Limitation and Utilization...
February 2017: Health Services Research
https://www.readbyqxmd.com/read/26958831/lens-regeneration-using-endogenous-stem-cells-with-gain-of-visual-function
#20
Haotian Lin, Hong Ouyang, Jie Zhu, Shan Huang, Zhenzhen Liu, Shuyi Chen, Guiqun Cao, Gen Li, Robert A J Signer, Yanxin Xu, Christopher Chung, Ying Zhang, Danni Lin, Sherrina Patel, Frances Wu, Huimin Cai, Jiayi Hou, Cindy Wen, Maryam Jafari, Xialin Liu, Lixia Luo, Jin Zhu, Austin Qiu, Rui Hou, Baoxin Chen, Jiangna Chen, David Granet, Christopher Heichel, Fu Shang, Xuri Li, Michal Krawczyk, Dorota Skowronska-Krawczyk, Yujuan Wang, William Shi, Daniel Chen, Zheng Zhong, Sheng Zhong, Liangfang Zhang, Shaochen Chen, Sean J Morrison, Richard L Maas, Kang Zhang, Yizhi Liu
The repair and regeneration of tissues using endogenous stem cells represents an ultimate goal in regenerative medicine. To our knowledge, human lens regeneration has not yet been demonstrated. Currently, the only treatment for cataracts, the leading cause of blindness worldwide, is to extract the cataractous lens and implant an artificial intraocular lens. However, this procedure poses notable risks of complications. Here we isolate lens epithelial stem/progenitor cells (LECs) in mammals and show that Pax6 and Bmi1 are required for LEC renewal...
March 17, 2016: Nature
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