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Sean J. Morrison

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https://www.readbyqxmd.com/read/28714970/bone-marrow-adipocytes-promote-the-regeneration-of-stem-cells-and-haematopoiesis-by-secreting-scf
#1
Bo O Zhou, Hua Yu, Rui Yue, Zhiyu Zhao, Jonathan J Rios, Olaia Naveiras, Sean J Morrison
Endothelial cells and leptin receptor(+) (LepR(+)) stromal cells are critical sources of haematopoietic stem cell (HSC) niche factors, including stem cell factor (SCF), in bone marrow. After irradiation or chemotherapy, these cells are depleted while adipocytes become abundant. We discovered that bone marrow adipocytes synthesize SCF. They arise from Adipoq-Cre/ER(+) progenitors, which represent ∼5% of LepR(+) cells, and proliferate after irradiation. Scf deletion using Adipoq-Cre/ER inhibited haematopoietic regeneration after irradiation or 5-fluorouracil treatment, depleting HSCs and reducing mouse survival...
July 17, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28698301/prdm16-is-required-for-the-maintenance-of-neural-stem-cells-in-the-postnatal-forebrain-and-their-differentiation-into-ependymal-cells
#2
Issei S Shimada, Melih Acar, Rebecca J Burgess, Zhiyu Zhao, Sean J Morrison
We and others showed previously that PR domain-containing 16 (Prdm16) is a transcriptional regulator required for stem cell function in multiple fetal and neonatal tissues, including the nervous system. However, Prdm16 germline knockout mice died neonatally, preventing us from testing whether Prdm16 is also required for adult stem cell function. Here we demonstrate that Prdm16 is required for neural stem cell maintenance and neurogenesis in the adult lateral ventricle subventricular zone and dentate gyrus. We also discovered that Prdm16 is required for the formation of ciliated ependymal cells in the lateral ventricle...
July 11, 2017: Genes & Development
https://www.readbyqxmd.com/read/28686011/glucosylceramide-and-glucosylsphingosine-quantitation-by-liquid-chromatography-tandem-mass-spectrometry-to-enable-in-vivo-preclinical-studies-of-neuronopathic-gaucher-disease
#3
Rick L Hamler, Nastry Brignol, Sean W Clark, Sean Morrison, Leo B Dungan, Hui H Chang, Richie Khanna, Michelle Frascella, Kenneth J Valenzano, Elfrida R Benjamin, Robert E Boyd
Gaucher disease (GD) is caused by mutations in the GBA1 gene that encodes the lysosomal enzyme acid -glucosidase (GCase). Reduced GCase activity primarily leads to the accumulation of two substrates, glucosylceramide (GlcCer) and glucosylsphingosine (GlcSph). Current treatment options have not been shown to ameliorate the neurological pathology observed in the most severe forms of GD, clearly representing an unmet medical need. To better understand the relationship between GlcCer and GlcSph accumulation, and ultimately their connection with the progression of neurological pathology, we developed LC-MS/MS methods to quantify GlcCer and GlcSph in mouse brain tissue...
July 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28637734/pregnancy-specific-stress-fetoplacental-haemodynamics-and-neonatal-outcomes-in-women-with-small-for-gestational-age-pregnancies-a-secondary-analysis-of-the-multicentre-prospective-observational-trial-to-optimise-paediatric-health-in-intrauterine-growth-restriction
#4
Terri A Levine, Ruth E Grunau, Ricardo Segurado, Sean Daly, Michael P Geary, Mairead M Kennelly, Keelin O'Donoghue, Alyson Hunter, John J Morrison, Gerard Burke, Patrick Dicker, Elizabeth C Tully, Fergal D Malone, Fiona A Alderdice, Fionnuala M McAuliffe
OBJECTIVES: To examine associations between maternal pregnancy-specific stress and umbilical (UA PI) and middle cerebral artery pulsatility indices (MCA PI), cerebroplacental ratio, absent end diastolic flow (AEDF), birthweight, prematurity, neonatal intensive care unit admission and adverse obstetric outcomes in women with small for gestational age pregnancies. It was hypothesised that maternal pregnancy-specific stress would be associated with fetoplacental haemodynamics and neonatal outcomes...
June 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28604734/adult-haematopoietic-stem-cell-niches
#5
REVIEW
Genevieve M Crane, Elise Jeffery, Sean J Morrison
Stem cell niches are specialized microenvironments that promote the maintenance of stem cells and regulate their function. Recent advances have improved our understanding of the niches that maintain adult haematopoietic stem cells (HSCs). These advances include new markers for HSCs and niche cells, systematic analyses of the expression patterns of niche factors, genetic tools for functionally identifying niche cells in vivo, and improved imaging techniques. Together, they have shown that HSC niches are perivascular in the bone marrow and spleen...
June 12, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28574529/prospective-cohort-study-of-hospitalized-adults-with-advanced-cancer-associations-between-complications-comorbidity-and-utilization
#6
Peter May, Melissa M Garrido, Melissa D Aldridge, J Brian Cassel, Amy S Kelley, Diane E Meier, Charles Normand, Joan D Penrod, Thomas J Smith, R Sean Morrison
BACKGROUND: Inpatient hospital stays account for more than a third of direct medical cancer care costs. Evidence on factors driving these costs can inform planning of services, as well as consideration of equity in access. OBJECTIVE: To measure the association between hospital costs, and demographic, clinical, and system factors, for a cohort of adults with advanced cancer. DESIGN: Prospective multisite cohort study. SETTING: Four medical and cancer centers...
June 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/28465357/identification-of-hair-shaft-progenitors-that-create-a-niche-for-hair-pigmentation
#7
Chung-Ping Liao, Reid C Booker, Sean J Morrison, Lu Q Le
Hair differentiates from follicle stem cells through progenitor cells in the matrix. In contrast to stem cells in the bulge, the identities of the progenitors and the mechanisms by which they regulate hair shaft components are poorly understood. Hair is also pigmented by melanocytes in the follicle. However, the niche that regulates follicular melanocytes is not well characterized. Here, we report the identification of hair shaft progenitors in the matrix that are differentiated from follicular epithelial cells expressing transcription factor KROX20...
April 15, 2017: Genes & Development
https://www.readbyqxmd.com/read/28460020/tnf-%C3%AE-and-stnf-rii-are-associated-with-pain-following-hip-fracture-surgery-in-older-adults
#8
Fred C Ko, William J Rubenstein, Eric J Lee, Albert L Siu, R Sean Morrison
Objective.:  To explore whether plasma inflammatory mediators on postoperative day 3 (POD3) are associated with pain scores in older adults after hip fracture surgery. Design.:  Cross-sectional study. Setting. : Mount Sinai Hospital, New York, New York. Subjects. : Forty patients age 60 years or older who presented with acute hip fracture at Mount Sinai Hospital between November 2011 and April 2013. Methods...
April 28, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28278423/digoxin-plus-trametinib-therapy-achieves-disease-control-in-braf-wild-type-metastatic-melanoma-patients
#9
Arthur E Frankel, Ugur Eskiocak, Jennifer G Gill, Stacy Yuan, Vijayashree Ramesh, Thomas W Froehlich, Chul Ahn, Sean J Morrison
This is the first prospective study of a combination therapy involving a cardenolide and a MEK inhibitor for metastatic melanoma. Whereas BRAF mutant melanomas can exhibit profound responses to treatment with BRAF and MEK inhibitors, there are fewer options for BRAF wild-type melanomas. In preclinical studies, we discovered that cardenolides synergize with MEK inhibitor to promote the regression of patient-derived xenografts irrespective of BRAF mutation status. We therefore conducted a phase 1B study of digoxin 0...
April 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28213060/prediction-of-cesarean-delivery-in-the-term-nulliparous-woman-results-from-the-prospective-multicenter-genesis%C3%A2-study
#10
Naomi Burke, Gerard Burke, Fionnuala Breathnach, Fionnuala McAuliffe, John J Morrison, Michael Turner, Samina Dornan, John R Higgins, Amanda Cotter, Michael Geary, Peter McParland, Sean Daly, Fiona Cody, Pat Dicker, Elizabeth Tully, Fergal D Malone
BACKGROUND: In contemporary practice many nulliparous women require intervention during childbirth such as operative vaginal delivery or cesarean delivery (CD). Despite the knowledge that the increasing rate of CD is associated with increasing maternal age, obesity and larger infant birthweight, we lack a reliable method to predict the requirement for such potentially hazardous obstetric procedures during labor and delivery. This issue is important, as there are greater rates of morbidity and mortality associated with unplanned CD performed in labor compared with scheduled CDs...
February 16, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28156192/cost-analysis-of-a-prospective-multi-site-cohort-study-of-palliative-care-consultation-teams-for-adults-with-advanced-cancer-where-do-cost-savings-come-from
#11
Peter May, Melissa M Garrido, J Brian Cassel, Amy S Kelley, Diane E Meier, Charles Normand, Thomas J Smith, R Sean Morrison
BACKGROUND: Studies report cost-savings from hospital-based palliative care consultation teams compared to usual care only, but drivers of observed differences are unclear. AIM: To analyse cost-differences associated with palliative care consultation teams using two research questions: (Q1) What is the association between early palliative care consultation team intervention, and intensity of services and length of stay, compared to usual care only? (Q2) What is the association between early palliative care consultation team intervention and day-to-day hospital costs, compared to a later intervention? DESIGN: Prospective multi-site cohort study (2007-2011)...
April 2017: Palliative Medicine
https://www.readbyqxmd.com/read/28122244/distinct-brca1-mutations-differentially-reduce-hematopoietic-stem-cell-function
#12
Victoria E Mgbemena, Robert A J Signer, Ranjula Wijayatunge, Travis Laxson, Sean J Morrison, Theodora S Ross
BRCA1 is a well-known DNA repair pathway component and a tissue-specific tumor suppressor. However, its role in hematopoiesis is uncertain. Here, we report that a cohort of patients heterozygous for BRCA1 mutations experienced more hematopoietic toxicity from chemotherapy than those with BRCA2 mutations. To test whether this reflects a requirement for BRCA1 in hematopoiesis, we generated mice with Brca1 mutations in hematopoietic cells. Mice homozygous for a null Brca1 mutation in the embryonic hematopoietic system (Vav1-iCre;Brca1(F22-24/F22-24)) developed hematopoietic defects in early adulthood that included reduced hematopoietic stem cells (HSCs)...
January 24, 2017: Cell Reports
https://www.readbyqxmd.com/read/28052317/prenatal-prediction-of-significant-intertwin-birthweight-discordance-using-standard-second-and-third-trimester-sonographic-parameters
#13
Mark P Hehir, Fionnuala M Breathnach, Jennifer L Hogan, Fionnuala M Mcauliffe, Michael P Geary, Sean Daly, John Higgins, Alyson Hunter, John J Morrison, Gerard Burke, Rhona Mahony, Patrick Dicker, Elizabeth Tully, Fergal D Malone
INTRODUCTION: Our study aim was to evaluate standard ultrasound-derived fetal biometric parameters in the prediction of clinically significant intertwin birthweight discordance defined as ≥18%. MATERIAL AND METHODS: This was a secondary analysis of a prospective cohort study of 1028 unselected twin pairs recruited over a two-year period. Dichorionic twins underwent two-weekly ultrasonographic surveillance from 24 weeks' gestation, with surveillance of monochorionic twins two-weekly from 16 weeks...
April 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28006086/recurrent-oral-cavity-cancer-patterns-of-failure-after-salvage-multimodality-therapy
#14
Sean R Quinlan-Davidson, William H Morrison, Jeffrey N Myers, Gary B Gunn, William N William, Beth M Beadle, Heath D Skinner, Ann M Gillenwater, Steven J Frank, Jack Phan, Faye M Johnson, Clifton D Fuller, Mark E Zafereo, David I Rosenthal, Adam S Garden
BACKGROUND: We focused on a cohort of radiation naïve patients who had recurrent oral cavity cancer (recurrent OCC) to assess their outcomes with salvage multimodal therapy. METHODS: A retrospective single institutional study was performed of patients with recurrent OCC. Disease recurrence and survival outcomes were assessed. RESULTS: Seventy-eight patients were analyzed. All patients had salvage surgery and intensity-modulated radiotherapy (IMRT) and 74% had chemotherapy...
December 22, 2016: Head & Neck
https://www.readbyqxmd.com/read/27988273/the-association-of-maximum-troponin-values-post-out-of-hospital-cardiac-arrest-with-electrocardiographic-findings-cardiac-reperfusion-procedures-and-survival-to-discharge-a-sub-study-of-roc-primed
#15
Laurie J Morrison, Sean M Devlin, Michael C Kontos, Sheldon Cheskes, Tom P Aufderheide, Jim Christenson, Joseph P Ornato, Ian G Stiell, Valeria E Rac, Andrew J Thomas, Jane G Wigginton, Paul Dorian
BACKGROUND: The role of Troponin (Tn) levels in the management of patients post out-of-hospital cardiac arrest (OHCA) is unclear. METHODS: All OHCA patients enrolled in the Resuscitation Outcomes Consortium Prehospital Resuscitation using an IMpedance valve and Early versus Delayed analysis trial and admitted to hospital with a Tn level and a 12-lead electrocardiogram were stratified by ST elevation (STE) or no STE in a regression model for survival to discharge adjusted for Utstein predictors and site...
February 2017: Resuscitation
https://www.readbyqxmd.com/read/27976999/clec11a-osteolectin-is-an-osteogenic-growth-factor-that-promotes-the-maintenance-of-the-adult-skeleton
#16
Rui Yue, Bo Shen, Sean J Morrison
Bone marrow stromal cells maintain the adult skeleton by forming osteoblasts throughout life that regenerate bone and repair fractures. We discovered that subsets of these stromal cells, osteoblasts, osteocytes, and hypertrophic chondrocytes secrete a C-type lectin domain protein, Clec11a, which promotes osteogenesis. Clec11a-deficient mice appeared developmentally normal and had normal hematopoiesis but reduced limb and vertebral bone. Clec11a-deficient mice exhibited accelerated bone loss during aging, reduced bone strength, and delayed fracture healing...
December 13, 2016: ELife
https://www.readbyqxmd.com/read/27919080/corrigendum-lens-regeneration-using-endogenous-stem-cells-with-gain-of-visual-function
#17
Haotian Lin, Hong Ouyang, Jie Zhu, Shan Huang, Zhenzhen Liu, Shuyi Chen, Guiqun Cao, Gen Li, Robert A J Signer, Yanxin Xu, Christopher Chung, Ying Zhang, Danni Lin, Sherrina Patel, Frances Wu, Huimin Cai, Jiayi Hou, Cindy Wen, Maryam Jafari, Xialin Liu, Lixia Luo, Jin Zhu, Austin Qiu, Rui Hou, Baoxin Chen, Jiangna Chen, David Granet, Christopher Heichel, Fu Shang, Xuri Li, Michal Krawczyk, Dorota Skowronska-Krawczyk, Yujuan Wang, William Shi, Daniel Chen, Zheng Zhong, Sheng Zhong, Liangfang Zhang, Shaochen Chen, Sean J Morrison, Richard L Maas, Kang Zhang, Yizhi Liu
No abstract text is available yet for this article.
January 26, 2017: Nature
https://www.readbyqxmd.com/read/27810850/how-empowering-is-hospital-care-for-older-people-with-advanced-disease-barriers-and-facilitators-from-a-cross-national-ethnography-in-england-ireland-and-the-usa
#18
Lucy Ellen Selman, Barbara A Daveson, Melinda Smith, Bridget Johnston, Karen Ryan, R Sean Morrison, Caty Pannell, Regina McQuillan, Suzanne de Wolf-Linder, Steven Z Pantilat, Lara Klass, Diane Meier, Charles Normand, Irene J Higginson
Background: patient empowerment, through which patients become self-determining agents with some control over their health and healthcare, is a common theme across health policies globally. Most care for older people is in the acute setting, but there is little evidence to inform the delivery of empowering hospital care. Objective: we aimed to explore challenges to and facilitators of empowerment among older people with advanced disease in hospital, and the impact of palliative care...
March 1, 2017: Age and Ageing
https://www.readbyqxmd.com/read/27787895/regional-nerve-blocks-improve-pain-and-functional-outcomes-in-hip-fracture-a-randomized-controlled-trial
#19
RANDOMIZED CONTROLLED TRIAL
R Sean Morrison, Eitan Dickman, Ula Hwang, Saadia Akhtar, Taja Ferguson, Jennifer Huang, Christina L Jeng, Bret P Nelson, Meg A Rosenblatt, Jeffrey H Silverstein, Reuben J Strayer, Toni M Torrillo, Knox H Todd
OBJECTIVES: To compared outcomes of regional nerve blocks with those of standard analgesics after hip fracture. DESIGN: Multisite randomized controlled trial from April 2009 to March 2013. SETTING: Three New York hospitals. PARTICIPANTS: Individuals with hip fracture (N = 161). INTERVENTION: Participants were randomized to receive an ultrasound-guided, single-injection, femoral nerve block administered by emergency physicians at emergency department (ED) admission followed by placement of a continuous fascia iliaca block by anesthesiologists within 24 hours (n = 79) or conventional analgesics (n = 82)...
December 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27681157/erratum-synergistic-effects-of-ion-transporter-and-map-kinase-pathway-inhibitors-in-melanoma
#20
Ugur Eskiocak, Vijayashree Ramesh, Jennifer G Gill, Zhiyu Zhao, Stacy W Yuan, Meng Wang, Travis Vandergriff, Mark Shackleton, Elsa Quintana, Arthur E Frankel, Timothy M Johnson, Ralph J DeBerardinis, Sean J Morrison
No abstract text is available yet for this article.
September 29, 2016: Nature Communications
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