Anna Felberg, Michał Bieńkowski, Tomasz Stokowy, Kamil Myszczyński, Zuzanna Polakiewicz, Kamila Kitowska, Rafał Sądej, Frida Mohlin, Alicja Kuźniewska, Daria Kowalska, Grzegorz Stasiłojć, Ilse Jongerius, Robbert Spaapen, Miguel Mesa-Guzman, Luis M Montuenga, Anna M Blom, Ruben Pio, Marcin Okrój
While numerous membrane-bound complement inhibitors protect the body's cells from innate immunity's autoaggression, soluble inhibitors like complement factor I (FI) are rarely produced outside the liver. Previously, we reported the expression of FI in non-small cell lung cancer (NSCLC) cell lines. Now, we assessed the content of FI in cancer biopsies from lung cancer patients and associated the results with clinicopathological characteristics and clinical outcomes. Immunohistochemical staining intensity did not correlate with age, smoking status, tumor size, stage, differentiation grade, and T cell infiltrates, but was associated with progression-free survival (PFS), overall survival (OS) and disease-specific survival (DSS)...
February 21, 2024: Translational Research: the Journal of Laboratory and Clinical Medicine