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https://www.readbyqxmd.com/read/28748107/study-protocol-a-mixed-methods-feasibility-study-for-a-loaded-self-managed-exercise-programme-for-patellofemoral-pain
#1
Benjamin E Smith, Paul Hendrick, Marcus Bateman, Fiona Moffatt, Michael Skovdal Rathleff, James Selfe, Toby O Smith, Pip Logan
BACKGROUND: Patellofemoral pain (PFP) is one of the most common forms of knee pain in adults under the age of 40, with a prevalence of 23% in the general population. The long-term prognosis is poor, with only one third of people pain-free 1 year after diagnosis. The biomedical model of pain in relation to persistent PFP has recently been called into question. It has been suggested that interventions for chronic musculoskeletal conditions should consider alternative mechanisms of action, beyond muscles and joints...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28746980/single-incision-sling-operations-for-urinary-incontinence-in-women
#2
REVIEW
Arjun Nambiar, June D Cody, Stephen T Jeffery, Patricia Aluko
BACKGROUND: Urinary incontinence has been shown to affect up to 50% of women. Studies in the USA have shown that up to 80% of these women have an element of stress urinary incontinence. This imposes significant health and economic burden on society and the women affected. Colposuspension and now mid-urethral slings have been shown to be effective in treating patients with stress incontinence. However, associated adverse events include bladder and bowel injury, groin pain and haematoma formation...
July 26, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28744844/suspected-adverse-effects-after-human-papillomavirus-vaccination-a-temporal-relationship-between-vaccine-administration-and-the-appearance-of-symptoms-in-japan
#3
Kazuki Ozawa, Akiyo Hineno, Tomomi Kinoshita, Sakiko Ishihara, Shu-Ichi Ikeda
INTRODUCTION: In Japan, after receiving human papillomavirus vaccination, a significant number of adolescent girls experienced various symptoms, the vast majority of which have been ascribed to chronic regional pain syndrome, orthostatic intolerance, and/or cognitive dysfunction. However, a causal link has not been established between human papillomavirus vaccination and the development of these symptoms. OBJECTIVE: The aim of this study was to clarify the temporal relationship between human papillomavirus vaccination and the appearance of post-vaccination symptoms...
July 25, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28743786/outcomes-of-patients-presenting-with-clinical-indices-of-spontaneous-reperfusion-in-st-elevation-acute-coronary-syndrome-undergoing-deferred-angiography
#4
Paul Fefer, Roy Beigel, Shaul Atar, Doron Aronson, Arthur Pollak, Doron Zahger, Elad Asher, Zaza Iakobishvili, Nir Shlomo, Ronny Alcalai, Michal Einhorn-Cohen, Amit Segev, Ilan Goldenberg, Shlomi Matetzky
BACKGROUND: Few data are available regarding the optimal management of ST-elevation myocardial infarction patients with clinically defined spontaneous reperfusion (SR). We report on the characteristics and outcomes of patients with SR in the primary percutaneous coronary intervention era, and assess whether immediate reperfusion can be deferred. METHODS AND RESULTS: Data were drawn from a prospective nationwide survey, ACSIS (Acute Coronary Syndrome Israeli Survey)...
July 25, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28740934/patient-reported-distress-and-survival-among-patients-receiving-definitive-radiation-therapy
#5
Yacob Habboush, Robert P Shannon, Shehzad K Niazi, Laeticia Hollant, Megan Single, Katherine Gaines, Bridget Smart, Nicolette T Chimato, Michael G Heckman, Steven J Buskirk, Laura A Vallow, Katherine S Tzou, Stephen J Ko, Jennifer L Peterson, Heather A Biers, Atiya B Day, Kimberly A Nelson, Jeff A Sloan, Michele Y Halyard, Robert C Miller
OBJECTIVE: Patient-reported distress (PRD) has not been well assessed in association with survival after radiation therapy (RT). The aims of this study were to evaluate the association between PRD level and survival after definitive RT and to identify the main causes of distress in definitive RT patients. METHODS AND MATERIALS: A total of 678 consecutive patients receiving definitive RT at our institution from April 2012 through May 2015 were included. All patients answered a PRD questionnaire that contained 30 items related to possible causes of distress, which could be rated from 1 (no distress) to 5 (high distress)...
April 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28740893/stereotactic-body-radiotherapy-sbrt-for-locally-advanced-extrahepatic-and-intrahepatic-cholangiocarcinoma
#6
Kiri A Sandler, Darlene Veruttipong, Vatche G Agopian, Richard S Finn, Johnny C Hong, Fady M Kaldas, Saeed Sadeghi, Ronald W Busuttil, Percy Lee
OBJECTIVES: We report single-institution clinical efficacy and safety outcomes for patients with unresectable locally advanced cholangiocarcinoma who were treated with stereotactic body radiation therapy (SBRT) and a subset of patients who received neoadjuvant SBRT and chemotherapy as part of an orthotopic liver transplantation (OLT) protocol. METHODS AND MATERIALS: From October 2008 to June 2015, 31 consecutive patients with unresectable extrahepatic (n = 25) or intrahepatic (n = 6) cholangiocarcinoma were treated with SBRT and retrospectively analyzed...
October 2016: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28737077/systematic-screening-of-adverse-reactions-to-metal-debris-after-recap-m2a-magnum-metal-on-metal-total-hip-arthroplasty
#7
H Mäntymäki, M Junnila, P Lankinen, M Seppänen, T Vahlberg, K T Mäkelä
BACKGROUND AND AIMS: An adverse reaction to metal debris is a known complication after large diameter head metal-on-metal total hip arthroplasty. However, the failure rate varies depending on the implant design. Therefore, we investigated the prevalence of adverse reaction to metal debris, as well as the symptoms and risk factors after undergoing a ReCap-M2a-Magnum large diameter head metal-on-metal total hip arthroplasty. MATERIALS AND METHODS: Between 2005 and 2012, 1188 patients (1329 hips) underwent ReCap-M2a-Magnum total hip arthroplasty at our institution...
March 1, 2017: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/28736592/a-multicenter-prospective-survey-of-adverse-events-associated-with-acupuncture-and-moxibustion-in-japan
#8
Nobutatsu Furuse, Hisashi Shinbara, Akihito Uehara, Masaaki Sugawara, Toshiya Yamazaki, Masayoshi Hosaka, Hitoshi Yamashita
Background: There have been only a few prospective surveys on adverse events (AEs) in Japanese-style acupuncture practice, and these surveys were conducted only in a single college acupuncture clinic. Objective: The goal of this research was to assess the safety of acupuncture and moxibustion performed in educational facilities in Japan. Materials and Methods: This was a multicenter prospective survey, using paper reporting forms. It was conducted in eight acupuncture clinics affiliated with educational institutions...
June 1, 2017: Medical Acupuncture
https://www.readbyqxmd.com/read/28736335/tfos-dews-ii-definition-and-classification-report
#9
REVIEW
Jennifer P Craig, Kelly K Nichols, Esen K Akpek, Barbara Caffery, Harminder S Dua, Choun-Ki Joo, Zuguo Liu, J Daniel Nelson, Jason J Nichols, Kazuo Tsubota, Fiona Stapleton
The goals of the TFOS DEWS II Definition and Classification Subcommittee were to create an evidence-based definition and a contemporary classification system for dry eye disease (DED). The new definition recognizes the multifactorial nature of dry eye as a disease where loss of homeostasis of the tear film is the central pathophysiological concept. Ocular symptoms, as a broader term that encompasses reports of discomfort or visual disturbance, feature in the definition and the key etiologies of tear film instability, hyperosmolarity, and ocular surface inflammation and damage were determined to be important for inclusion in the definition...
July 2017: Ocular Surface
https://www.readbyqxmd.com/read/28735117/pubic-osteomyelitis-after-surgery-for-perforated-colonic-diverticulitis-with-fecal-peritonitis-a-case-report
#10
Daichi Kitaguchi, Tsuyoshi Enomoto, Yusuke Ohara, Tatsuya Oda, Nobuhiro Ohkohchi
INTRODUCTION: Pubic osteomyelitis is a rare type of suppurative osteomyelitis. Early diagnosis of pubic osteomyelitis is difficult, and prolonged inflammation results in progressive bone degradation, severe pelvic pain and a wide-based gait. PRESENTATION OF CASE: We report the case of an 82-year-old woman who was admitted to a previous hospital with severe abdominal pain caused by a perforated colonic diverticulum with fecal peritonitis. She underwent an emergency operation and a postoperative wound infection occurred...
July 13, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28734747/retroperitoneal-fibrosis-associated-with-immunoglobulin-g4-related-disease-in-the-differential-diagnosis-in-retroperitoneal-tumors-case-report
#11
Gabriela Ruiz Mar, Óscar E Cárdenas Serrano, Jorge Roldan García, A Cañavera-Constantino, Víctor M Menéndez Trejo, Óscar Chapa Azuela
The patient was a 55-year-old woman with a 4-month history of pain in left flank that irradiated to the lumbar region. Computed tomography revealed a cystic tumor in the retroperitoneal region that compresses the ureter and left renal pelvis in contact with pancreatic body and tail. Surgery was performed and the definitive pathological report diagnosed nodular retroperitoneal fibrosis associated with IgG4; Ki67-positive in germinal centers (5%) and IgG4-positive (40 plasma cells in 3 fields of 40x) by immunohistochemistry...
July 19, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28733740/laparoscopic-splenopexy-for-wandering-spleen-a-video-demonstration-of-technique-by-encircling-the-spleen-with-polyglactin-910-woven-mesh
#12
Sheridan Morgan, Ian Glenn, Oliver Soldes
BACKGROUND: Wandering spleen is a rare clinical entity caused by absence of the spleen's peritoneal attachments, allowing the spleen to move freely within the peritoneal cavity [1]. This disease is most commonly seen in children and young women [1, 2]. Affected individuals are predisposed to complications including splenic torsion, splenic infarction, and pancreatic necrosis [3, 4]. Patients may present with constipation, an abdominal mass, swelling, or acute abdominal pain if splenic torsion has occurred [4]...
July 21, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28733296/a-unified-multi-level-model-approach-to-assessing-patient-responsiveness-including-return-to-normal-minimally-important-differences-and-minimal-clinically-important-improvement-for-patient-reported-outcome-measures
#13
Adrian Sayers, Vikki Wylde, Erik Lenguerrand, Rachael Gooberman-Hill, Jill Dawson, David Beard, Andrew Price, Ashley W Blom
OBJECTIVE: This article reviews and compares four commonly used approaches to assess patient responsiveness with a treatment or therapy (return to normal (RTN), minimal important difference (MID), minimal clinically important improvement (MCII), OMERACT-OARSI [Outcome Measures in Rheumatology-Osteoarthris Reseach Society International] (OO)) and demonstrates how each of the methods can be formulated in a multilevel modelling (MLM) framework. DESIGN: Cohort study...
July 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28727700/therapeutic-role-of-placebo-evolution-of-a-new-paradigm-in-understanding-research-and-clinical-practice
#14
Laxmaiah Manchikanti, Mark V Boswell, Alan D Kaye, Standiford Helm Ii, Joshua A Hirsch
Research into interventional techniques in managing chronic spinal pain continues to be challenging, mystifying, confusing, and biased. Insight, or lack thereof, into placebo and nocebo phenomena contributes mightily to these difficulties. Unfortunately, placebo-nocebo responses are the subject of numerous controversies and challenges from not only a research perspective, but also clinical perspective. While interventionalists consider the biggest threat to interventional pain management research is inappropriate and outdated interpretation of the data, a greater problem is the misuse of the placebo response in research, with the declaration that all and everything as a placebo effect: with a misinterpretation of the nature of the placebo the, associated conclusions can be inaccurate...
July 2017: Pain Physician
https://www.readbyqxmd.com/read/28726651/factors-associated-with-post-stroke-fatigue-within-the-first-3-month-after-stroke
#15
I Delva, N Lytvynenko, M Delva
Aim - identify socio-demographic, personal and psychological factors associated with certain post-stroke fatigue (PSF) domains within first 3 months after stroke. There were examined patients consequently in definite time points after ischemic or hemorrhagic strokes: at hospital stay (234 patients), in 1 month (203 patients) and in 3 months (176 patients). Global PSF and certain PSF domains were measured by multidimensional fatigue inventory-20 (MFI-20) scale. In multivariate logistic regression analysis the majority of variables (gender, marital status, education level, smoking status, level of alcohol consumption, apathetic impairments, arterial hypertension, atrial fibrillation, ischemic heart disease, diabetes mellitus, body mass index, waist circumference) were not significantly associated with any PSF domain risk at any time point after stroke...
June 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28726577/will-optogenetics-be-used-to-treat-chronic-pain-patients
#16
Hélène Beaudry, Ihab Daou, Alfredo Ribeiro-da-Silva, Philippe Séguéla
Chronic pain affects a third of the population and current treatments produce limited relief and severe side effects. An alternative strategy to decrease pain would be to directly modulate somatosensory pathways using optogenetics. Optogenetics involves the use of genetically encoded and optically active proteins, namely opsins, to control neuronal circuits. In preclinical animal models, optical silencing of peripheral nociceptors has been shown to alleviate both inflammatory and neuropathic pain. An opsin-based gene therapy to treat chronic pain patients is not ready yet, but encouraging advances have been made in optical and viral technology...
July 20, 2017: Pain Management
https://www.readbyqxmd.com/read/28725615/chronic-scrotal-pain-and-microsurgical-spermatic-cord-denervation-tricks-of-the-trade
#17
REVIEW
Alex Tatem, Jason R Kovac
Every practicing urologist encounters patients complaining of chronic scrotal content pain (CSCP). This condition can be equally frustrating for both patients and clinicians as there are no clear treatment guidelines, or pathways, for urologists to follow. As a result, most patients typically seek out multiple providers without improvements in their symptoms. Fortunately, microsurgical spermatic cord denervation (MSCD) is becoming an accepted, reliable and reproducible technique for definitively addressing CSCP in select patients...
May 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28724187/nasogastric-tube-as-abdominal-pressure-sensor-in-urodynamics-proof-of-concept-of-a-novel-approach
#18
Sundaramoorthy VijayGanapathy, Vilvapathy Senguttuvan Karthikeyan, Ashwin Mallya, Ali Poonawala, Ramaiah Keshavamurthy
AIMS: The standard sensor for abdominal pressure (Pabd) measurement in urodynamics (UD) is a rectal sensor. In patients where the rectum is not available due to prior surgery or when external anal sphincter (EAS) tone is poor, rectal sensor may slip, making Pabd recording unreliable. Vaginal Pabd measurement and wireless vaginal sensors have been tried. We present our preliminary series of a novel nasogastric tube (NG) sensor for Pabd measurement. METHODS: We identified patients undergoing UD with a NG Pabd sensor from a prospectively maintained UD database of a tertiary care urological center between July 2013 and December 2016...
July 19, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28722618/clinical-evidence-of-acute-mesoamerican-nephropathy
#19
Rebecca S B Fischer, Sreedhar Mandayam, Denis Chavarria, Chandan Vangala, Melissa N Garcia, Linda L Garcia, Lesbia Palma, Felix Garcia, Ramón García-Trabanino, Kristy O Murray
Mesoamerican nephropathy (MeN), an epidemic of unexplained kidney disease in Central America, affects mostly young, healthy individuals. Its etiology is a mystery that requires urgent investigation. Largely described as a chronic kidney disease (CKD), no acute clinical scenario has been characterized. An understanding of the early disease process could elucidate an etiology and guide treatment and prevention efforts. We sought to document the earliest clinical signs in patients with suspected MeN in a high-risk population in Nicaragua...
July 17, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28721575/gastroparesis-medical-and-therapeutic-advances
#20
REVIEW
Christopher M Navas, Nihal K Patel, Brian E Lacy
Gastroparesis is a chronic, bothersome, and often disabling neuromuscular disorder of the upper gastrointestinal tract. The most frequently reported symptoms of gastroparesis include nausea, vomiting, epigastric pain, early satiety, and unintentional weight loss. Etiologies of gastroparesis include diabetes, connective tissue disorders, prior infection, mesenteric ischemia, and post-surgical complications. The largest category of gastroparesis patients is comprised of those in whom no definitive cause can be identified (idiopathic gastroparesis)...
July 18, 2017: Digestive Diseases and Sciences
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