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https://www.readbyqxmd.com/read/29785683/targeted-therapies-and-adverse-drug-reactions-in-oncology-the-role-of-clinical-pharmacist-in-pharmacovigilance
#1
G Fornasier, M Taborelli, S Francescon, J Polesel, M Aliberti, P De Paoli, P Baldo
Background The majority of adverse drug reactions (ADRs) reported in the summary of product characteristics (SPCs) are based on pivotal clinical trials, performed under controlled conditions and with selected patients. Objectives (1) to observe ADRs in the real-world setting and to evaluate if the supervision of the pharmacist impacts on the management of ADRs and on the satisfaction of patients; (2) to sensitise health professionals and patients on the need to increase the reporting of ADRs, in compliance with Pharmacovigilance...
May 21, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29782289/-the-effect-of-changing-of-conventional-antihypertensive-therapy-to-a-triple-fixed-combination-therapy-with-rosuvastatin-in-high-cardiovascular-risk-patients
#2
F T Ageev, Z N Blankova, N S Samsonova
BACKGROUND: The low efficiency of recommended therapy for reducing cardiovascular risk (CV) in patients with arterial hypertension even with an effective blood pressure decrease is often due to the persistence of high blood cholesterol and arterial stiffness. Among the effective ways to achieve the goal of therapy is considered the changing to a single-pill combinations (SPCs) of two antihypertensive drugs and statin. AIM: To assess influence of fixed combination consisted of amlodipine, lisinopril and rosuvastatin to the dynamic of lipid spectrum, blood pressure level and elastic properties of arteries in patients with arterial hypertension and high risk of cardio-vascular complications being transferred from their preceding antihypertensive therapy...
2018: Kardiologiia
https://www.readbyqxmd.com/read/29715153/long-term-postoperative-nutritional-status-affects-prognosis-even-after-infectious-complications-in-gastric-cancer
#3
Jun Kiuchi, Shuhei Komatsu, Toshiyuki Kosuga, Takeshi Kubota, Kazuma Okamoto, Hirotaka Konishi, Atsushi Shiozaki, Hitoshi Fujiwara, Daisuke Ichikawa, Eigo Otsuji
AIM: This study was designed to investigate the clinical impact of postoperative serum albumin level on severe postoperative complications (SPCs) and prognosis. MATERIALS AND METHODS: Data for a total of 728 consecutive patients who underwent curative gastrectomy for gastric cancer between 2004 and 2013 were retrospectively analyzed. From these patients, a propensity score-matched analysis was performed based on 14 clinicopathological and surgical factors. RESULTS: Short-term decrease in postoperative serum albumin level was not associated with the occurrence of SPCs...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29668653/second-primary-cancers-and-survival-in-patients-with-gastric-cancer-association-with-prediagnosis-lifestyles
#4
Samantha Morais, Clara Castro, Luís Antunes, Bárbara Peleteiro, Maria J Bento, Nuno Lunet
To quantify the association between prediagnosis lifestyles with the risk of second primary cancers (SPCs) and survival of patients with gastric first primary cancer (FPC). We recruited 574 gastric patients from two major public hospitals in North Portugal (2001-2006). Smoking, alcohol and dietary habits in the year before FPC diagnosis were evaluated. Patients were followed up to 31 December 2011 for an SPC and to 31 May 2017 for vital status. Cox proportional hazards regression was used to estimate adjusted hazard ratios for incidence of an SPC or death...
April 17, 2018: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29659468/routine-versus-clinically-indicated-short-peripheral-catheter-replacement-an-evidence-based-practice-project
#5
Catherine Stevens, Kerry A Milner, Jennifer Trudeau
Despite current, high-quality, level 1 evidence that supports clinically indicated short peripheral catheter (SPC) replacement, the current practice in the health care system studied was to change SPCs routinely every 96 hours. A before-and-after design was used to evaluate the impact of SPC replacement when clinically indicated. Following the practice change, there were no SPC-related infections, monthly phlebitis rates ranged from 1.9% to 3.5%, and SPC use decreased by 14.2%, resulting in estimated cost savings of $2100 and 70 hours of nursing time saved...
May 2018: Journal of Infusion Nursing: the Official Publication of the Infusion Nurses Society
https://www.readbyqxmd.com/read/29659463/maintaining-short-peripheral-catheter-patency-a-comparison-of-saline-lock-versus-continuous-infusion-in-the-acute-care-setting
#6
Sheila Serr Roszell, Holly Barlowe Rabinovich, Cheryl A Smith-Miller
Sparse evidence exists about how short peripheral catheter (SPC) duration is affected by the presence of a saline lock versus continually infusing fluids. Often the choice to lock an SPC with saline is based on provider preference, rather than available evidence or patient-centered factors. This study compared the duration of 85 SPCs: locked with saline versus continuously running fluids. A secondary analysis considered the influence of a number of intermittent medications and flushes. Although the saline-locked group had a slightly longer duration time, it was not statistically significant...
May 2018: Journal of Infusion Nursing: the Official Publication of the Infusion Nurses Society
https://www.readbyqxmd.com/read/29616215/self-propagating-combustion-synthesis-luminescent-properties-and-photocatalytic-activities-of-pure-ca-12-al-14-o-33-tb-3-sm-3
#7
Rong Liu, Yongsheng Yan, Changchang Ma
The dual-functional Ca12 Al14 O33 : Tb3+ and Ca12 Al14 O33 : Sm3+ materials were prepared by the Self-Propagating Combustion Synthesis (SPCS) technology. The structure, morphology and light absorption property were investigated by XRD, FT-IR, UV-Vis DRS and SEM etc. The doping of Tb3+ and Sm3+ ions had not changed cubic structure of Ca12 Al14 O33 but leaded to the slight lattice dilatation and the red-shifts of absorption peaks/edges. The excitation and emission spectra indicated that Ca12 Al14 O33 : Tb3+ and Ca12 Al14 O33 : Sm3+ are superior green and red luminescent materials, respectively, and it displayed the distinctly refined structure characteristics which had importantly reference value for the energy level investigation of Tb3+ and Sm3+ ions...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29603332/solid-papillary-breast-carcinomas-resembling-the-tall-cell-variant-of-papillary-thyroid-neoplasms-solid-papillary-carcinomas-with-reverse-polarity-harbor-recurrent-mutations-affecting-idh2-and-pik3ca-a-validation-cohort
#8
John R Lozada, Thais Basili, Fresia Pareja, Barbara Alemar, Arnaud C Paula, Rodrigo Gularte-Merida, Dilip D Giri, Patrizia Querzoli, Gabor Cserni, Emad A Rakha, Maria Pia Foschini, Jorge S Reis-Filho, Edi Brogi, Britta Weigelt, Felipe C Geyer
AIMS: Solid papillary breast carcinoma resembling the tall cell variant of papillary thyroid neoplasms (BPTC), also known as solid papillary carcinoma with reverse polarity, is a rare histologic type of breast cancer that morphologically resembles the tall cell variant of papillary thyroid carcinoma. BPTCs are characterized by IDH2 R172 hotspot somatic mutations or mutually exclusive TET2 somatic mutations, concurrently with mutations affecting PI3K pathway-related genes. We sought to characterize their histology, and investigate the frequency of IDH2 and PIK3CA mutations in an independent cohort of BPTCs, as well as in conventional solid papillary carcinomas (SPCs)...
March 30, 2018: Histopathology
https://www.readbyqxmd.com/read/29602083/antiepileptic-drug-treatment-of-generalized-tonic-clonic-seizures-an-evaluation-of-regulatory-data-and-five-criteria-for-drug-selection
#9
REVIEW
Simon D Shorvon, Pedro E Bermejo, Ayana A Gibbs, Gilles Huberfeld, Reetta Kälviäinen
BACKGROUND: A generalized tonic-clonic seizure (GTCS) is the most severe form of common epileptic seizure and carries the greatest risk of harm. The aim of this review is to provide an evidence-based guide for the selection of antiepileptic drugs (AEDs) for patients with GTCSs. Eight AEDs are approved in Europe and the USA for the treatment of both primarily GTCSs (PGTCSs) and secondarily GTCSs (SGTCSs) and are considered in this paper. METHODS: Each AED is evaluated using five criteria: (1) efficacy, by seizure type (a: PGTCSs and b: SGTCSs); (2) adverse effects; (3) interactions; (4) adherence and dosing; and (5) mechanism of action (MOA)...
May 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29533011/excessive-risk-of-second-primary-cancers-in-young-onset-colorectal-cancer-survivors
#10
Xingkang He, Wenrui Wu, Yu'e Ding, Yue Li, Jianmin Si, Leimin Sun
With an increasing trend of patients with young-onset colorectal cancer (CRC), risks of second primary cancers (SPCs) among them become a concerning issue. We aimed to define the detailed risk and site-distributed patterns of SPCs in young CRC individuals (age ≤50). A population-based cohort were identified from the Surveillance, Epidemiology, and End Results database between 1973 and 2013. Standardized incidence ratios (SIRs) and absolute excess risk (AER) were calculated to assess the risk for SPCs compared with the general population...
April 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29495007/functional-morphology-of-thecal-glands-in-the-ovary-of-japanese-quails-coturnix-japonica
#11
Daniela Rodler, Fred Sinowatz
The role of thecal glands in the ovary of birds remains controversial. Using transmission electron microscopy and immunohistochemistry, immunohistochemical localisation of cyclooxygenase I and II (COX-1 and COX-2), oestrogen receptor α and β (ER-α and ER-β), androgen receptor (AR) and progesterone receptor (PR), a detailed analysis of the thecal glands was performed. Our ultrastructural studies revealed that the thecal glands of the quail ovary consist of 2 cell types, steroid-producing cells (SPCs) and enclosing cells (ENCs)...
2018: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/29480318/-outpatient-palliative-medicine-attitudes-in-the-care-of-palliative-emergencies-prospective-questionnaire-based-investigation
#12
REVIEW
C H R Wiese, V M C Silbereisen, B M Graf, A C Bundscherer, C L Lassen
BACKGROUND: The right to adequate outpatient palliative care has existed for several years in Germany. In recent years outpatient palliative care has developed very positively. Nevertheless, in emergency situations paramedics and emergency physicians were often included in the care of palliative care of patients. The aim of our study was to investigate the cooperation between outpatient palliative care teams and the emergency medical services. Another aim was to identify structural realities and based on these to discuss the possibilities in the optimization of outpatient palliative medical emergency situations...
March 2018: Der Anaesthesist
https://www.readbyqxmd.com/read/29440824/extracorporeal-membrane-oxygenation-in-pediatric-cardiac-surgery-a-retrospective-review-of-trends-and-outcomes-in-scotland
#13
Maziar Khorsandi, Mark Davidson, Omar Bouamra, Andrew McLean, Kenneth MacArthur, Ida Torrance, Gillian Wylie, Ed Peng, Mark Danton
Introduction: Around 3.2%-8.4% of patients receive venoarterial (VA) extracorporeal membrane oxygenation (ECMO) support after pediatric cardiac surgery. The desired outcome is "bridge-to-recovery" in most cases. There is no universally agreed protocol, and given the associated costs and complications rates, the decisions as of when and when not to institute VA ECMO are largely empirical. Methods: A retrospective review of the ECMO database at the Scottish Pediatric Cardiac Services (SPCS) was undertaken...
January 2018: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/29373309/metabolic-dependent-and-independent-ph-drop-shuts-down-virsr-quorum-sensing-in-clostridium-perfringens
#14
Keika Adachi, Kaori Ohtani, Michio Kawano, Ravindra Pal Singh, Basit Yousuf, Kenji Sonomoto, Tohru Shimizu, Jiro Nakayama
Clostridium perfringens produces various exotoxins and enzymes that cause food poisoning and gas gangrene. The genes involved in virulence are regulated by the agr-like quorum sensing (QS) system, which consists of a QS signal synthesis system and a VirSR two-component regulatory system (VirSR TCS) which is a global regulatory system composed of signal sensor kinase (VirS) and response regulator (VirR). We found that the perfringolysin O gene (pfoA) was transiently expressed during mid-log phase of bacterial growth; its expression was rapidly shut down thereafter, suggesting the existence of a self-quorum quenching (sQQ) system...
January 17, 2018: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/29370456/temporal-trends-in-the-risk-of-second-primary-cancers-among-survivors-of-adult-onset-cancers-1980-through-2013-an-australian-population-based-study
#15
Yuanzi Ye, Petr Otahal, Karen E Wills, Amanda L Neil, Alison J Venn
BACKGROUND: The authors' systematic review indicated an increasing trend in the risk of second primary cancers (SPCs) from the 1980s to 2000 when considering studies from the United States and Australia. It is uncertain whether this trend has continued to increase since 2000. METHODS: The current study was a population-based study of 51,802 individuals with adult-onset cancers identified in the Tasmanian Cancer Registry. Patients with a first cancer diagnosis made between 1980 and 2009 were followed up to December 2013...
April 15, 2018: Cancer
https://www.readbyqxmd.com/read/29355026/efficacy-outcomes-of-endovascular-versus-surgical-revascularization-in-critical-limb-ischemia-results-from-a-prospective-cohort-study
#16
Marc Schindewolf, Torsten Fuss, Hanspeter Fink, Armin Gemperli, Axel Haine, Iris Baumgartner
Data on efficacy outcomes of endovascular versus surgical revascularization in patients with critical limb ischemia (CLI) in contemporary practice are limited. In this prospective cohort study, 353 consecutive patients with CLI were enrolled and allocated to endovascular (PTA [percutaneous transluminal angioplasty]), surgical (SURG), or no revascularization (No REVASC) after interdisciplinary consensus. Outcome measures were sustained primary clinical success (sPCS; survival without major amputation, repeated target extremity revascularization, and freedom from CLI), limb salvage, and amputation-free survival...
January 1, 2018: Angiology
https://www.readbyqxmd.com/read/29327677/autologous-smooth-muscle-progenitor-cells-enhance-regeneration-of-tissue-engineered-bladder
#17
Liuhua Zhou, Jiadong Xia, Pengji Wang, Ruipeng Jia, Junhua Zheng, Xudong Yao, Yun Chen, Yutian Dai, Bin Yang
Tissue engineering techniques provide a great potential to de novo construct a histological bladder. Smooth muscle regeneration is extremely important for the functional recovery of engineered neobladder. However, many challenges remain for the use of bladder smooth muscle cells (SMCs) as the cell sources. Recent evidences showed that smooth muscle progenitor cells (SPCs) in the peripheral blood have the capacity of differentiating into SMCs, while their use for bladder regeneration has not yet been reported...
March 1, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29273656/pathways-to-diagnosis-of-a-second-primary-cancer-protocol-for-a-mixed-methods-systematic-review
#18
Lovney Kanguru, Annemieke Bikker, Debbie Cavers, Karen Barnett, David H Brewster, David Weller, Christine Campbell
INTRODUCTION: As cancer survivors continue to live longer, the incidence of second primary cancers (SPCs) will also rise. Relatively little is understood about the diagnostic pathway for SPCs, how people appraise, interpret symptoms and seek help for a second different cancer and the experiences (including challenges) of healthcare providers relating to SPCs. This study aims to systematically appraise and synthesise the literature on the pathways to diagnosis of an SPC and the associated patient and healthcare provider experiences...
December 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/29251761/single-pill-combinations-spcs-and-treatment-of-arterial-hypertension-in-poland-expert-consensus-statement-of-the-polish-society-of-hypertension-and-polish-cardiac-society-working-group-on-cardiovascular-pharmacotherapy
#19
Andrzej Tykarski, Krystyna Widecka, Krzysztof Narkiewicz, Beata Wożakowska-Kapłon, Zbigniew Gaciong, Stefan Grajek, Tomasz Grodzicki, Andrzej Januszewicz, Jacek Wolf, Aleksander Prejbisz, Katarzyna Kostka-Jeziorny, Krzysztof J Filipiak
The reasons for the publication of current expert consensus statement after 4 years from the previous one are: the growing number of evidence on the benefits of the use of single-pill combinations (SPCs) in hypertension (also with concomitant dyslipidaemia), the extension of indications for their use in the hypertension management algorithm and the emergence in recent years after the publication of Polish Society of Hypertension experts' position statement in 2013 of new types of SPCs available to doctors in Poland, including triple-drug combinations of antihypertensives and the so-called "hybrids" SPCs containing not only antihypertensive drugs but also statins...
2017: Kardiologia Polska
https://www.readbyqxmd.com/read/29215328/a-realist-evaluation-of-social-prescribing-an-exploration-into-the-context-and-mechanisms-underpinning-a-pathway-linking-primary-care-with-the-voluntary-sector
#20
Marcello Bertotti, Caroline Frostick, Patrick Hutt, Ratna Sohanpal, Dawn Carnes
This article adopts a realist approach to evaluate a social prescribing pilot in the areas of Hackney and City in London (United Kingdom). It unpacks the contextual factors and mechanisms that influenced the development of this pilot for the benefits of GPs, commissioners and practitioners, and reflects on the realist approach to evaluation as a tool for the evaluation of health interventions. Primary care faces considerable challenges including the increase in long-term conditions, GP consultation rates, and widening health inequalities...
December 7, 2017: Primary Health Care Research & Development
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