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https://www.readbyqxmd.com/read/28509722/rationale-for-nebivolol-valsartan-combination-for-hypertension-review-of-preclinical-and-clinical-data
#1
Thomas D Giles, John R Cockcroft, Bertram Pitt, Abhijeet Jakate, Harold M Wright
: To treat hypertension, combining two or more antihypertensive drugs from different classes is often necessary. β-Blockers and renin-angiotensin-aldosterone system inhibitors, when combined, have been deemed 'less effective' based on partially overlapping mechanisms of action and limited evidence. Recently, the single-pill combination (SPC) of nebivolol (Neb) 5 mg - a vasodilatory β1-selective antagonist/β3 agonist - and valsartan 80 mg, an angiotensin II receptor blocker, was US Food and Drug Administration-approved for hypertension...
May 15, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28454633/effective-cardiac-index-and-systemic-pulmonary-collaterals-evaluated-by-cardiac-magnetic-resonance-late-after-fontan-palliation
#2
Lamia Ait Ali, Alessandra Cadoni, Giuseppe Rossi, Petra Keilberg, Claudio Passino, Pierluigi Festa
The regulation of cardiac output in the Fontan circuit is not completely understood. Systemic-pulmonary collaterals (SPCs) are frequent in patients with univentricular heart, and their clinical significance and management remain controversial. The aims of our study were to identify factors associated with SPCs' flow at late follow-up after Fontan and evaluate the relation between SPCs flow (QSPCs) and the effective cardiac index (CI). From our cardiac magnetic resonance database, we identified all Fontan patients with a complete set of flow measurements allowing calculation of QSPCs and effective CI...
March 29, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28421722/second-primary-cancer-risk-among-kidney-cancer-patients-in-korea-a-population-based-cohort-study
#3
Jae Young Joung, Whi-An Kwon, Jiwon Lim, Chang-Mo Oh, Kyu-Won Jung, Sung Han Kim, Ho Kyung Seo, Weon Seo Park, Jinsoo Chung, Kang Hyun Lee, Young-Joo Won
Purpose: Secondary primary cancers (SPCs) commonly arise in patients with renal cell carcinoma (RCC). We designed the present study to estimate the SPC incidence in Korean patients with RCC. Materials and Methods: The study cohort was population-based and consisted of 40,347 individuals from the Korean Central Cancer Registry who were diagnosed with primary renal cancer between 1993 and 2013. Standardized incidence ratios (SIRs) for SPCs were estimated for different ages at diagnosis, latencies, diagnostic periods, and treatments...
April 19, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28419010/extending-short-peripheral-catheter-dwell-time-a-best-practice-discussion
#4
Brenda Ansel, Michelle Boyce, Jennifer L Embree
Complications involving short peripheral catheters (SPCs) can significantly affect health care costs, patient quality of life, morbidity, mortality, and treatment expense, especially when the hospital stay is lengthened. This article examines the relationship between SPC dwell time and the incidence of phlebitis and potential bacteremia. The literature is replete with most studies supporting SPCs remaining in situ until a clinical reason warrants catheter removal. Removing and not routinely restarting unneccessary intravenous catheters can help prevent catheter-related infections and other vascular complications and reduce cost...
May 2017: Journal of Infusion Nursing: the Official Publication of the Infusion Nurses Society
https://www.readbyqxmd.com/read/28408662/the-gdnf-responsive-phosphoprotein-landscape-identifies-raptor-phosphorylation-required-for-spermatogonial-progenitor-cell-proliferation
#5
Min Wang, Yueshuai Guo, Mei Wang, Tao Zhou, Yuanyuan Xue, Guihua Du, Xiang Wei, Jing Wang, Lin Qi, Hao Zhang, Lufan Li, Lan Ye, Xuejiang Guo, Xin Wu
Cytokine-dependent renewal of stem cells is a fundamental requisite for tissue homeostasis and regeneration. Spermatogonial progenitor cells (SPCs) including stem cells support life-long spermatogenesis and male fertility, but pivotal phosphorylation events that regulate fate decisions in SPCs remain unresolved. Here, we described a quantitative mass-spectrometry-based proteomic and phosphoproteomic analyses of SPCs following sustained stimulation with glial cell-derived neurotrophic factor (GDNF), an extrinsic factor supporting SPC proliferation...
April 13, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28401708/how-veterans-health-administration-suicide-prevention-coordinators-assess-suicide-risk
#6
James L Pease, Jeri E Forster, Collin L Davidson, Brooke Dorsey Holliman, Emma Genco, Lisa A Brenner
This cross-sectional study was designed to examine the suicide risk assessment practices of Suicide Prevention Coordinators (SPCs) within the Veterans Health Administration. Specifically, this study sought to (1) identify factors SPCs consider most important in assessing risk and patient priority; (2) measure the level of consistency and agreement between SPCs in assessing suicide risk and prioritizing cases; and (3) measure individual SPC consistency between cases. SPCs (n = 63) responded to online survey questions about imminent and prolonged risk for suicide in response to 30 fictional vignettes...
March 2017: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/28356721/the-influence-of-wearing-schemes-and-supportive-telephone-calls-on-adherence-in-accelerometry-measurement-results-of-a-randomized-controlled-trial
#7
Neeltje van den Berg, Sabina Ulbricht, Thea Schwaneberg, Kerstin Weitmann, Franziska Weymar, Stefan Groß, Marcus Dörr, Wolfgang Hoffmann
BACKGROUND: Physical activity (PA) can be assessed by accelerometer monitors. However, a high adherence to wearing this device is essential to obtain valid data. In this study, the influence of different wearing schemes and additional supportive phone calls (SPCs) on adherence was examined. METHODS: A randomized study with four groups was conducted in the context of a health examination program among participants aged 40-75 years without a history of cardiovascular diseases...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28286210/using-a-3-proton-density-fat-fraction-as-a-cut-off-value-increases-sensitivity-of-detection-of-hepatic-steatosis-based-on-results-from-histopathology-analysis
#8
Patrik Nasr, Mikael F Forsgren, Simone Ignatova, Nils Dahlström, Gunnar Cedersund, Olof Dahlqvist Leinhard, Bengt Norén, Mattias Ekstedt, Peter Lundberg, Stergios Kechagias
It is possible to estimate hepatic triglyceride content by calculating the proton density fat fraction (PDFF), using proton magnetic resonance spectroscopy ((1)H-MRS), instead of collecting and analyzing liver biopsies to detect steatosis. However, the current PDFF cut-off value (5%) used to define steatosis by magnetic resonance was derived from studies that did not use histopathology as the reference standard. We performed a prospective study to determine the accuracy of (1)H-MRS PDFF in measurement of steatosis using histopathology analysis as the standard...
March 9, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28274421/screening-and-evaluation-of-active-compounds-in-polyphenol-mixtures-by-hplc-coupled-with-chemical-methodology-and-its-application
#9
Yue Zhao, Ying Wang, Zi-Tao Jiang, Rong Li
An off-line high performance liquid chromatography (HPLC) coupled with chemical methods has been developed to evaluate antioxidant activity of 11 standard polyphenol compounds (SPCs) and vitamin C (Vc) in terms of radical scavenging abilities. The structure-activity relationships of each SPC were also discussed. SPCs showed different abilities in scavenging 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azinobis-3-ethyl-benzthiazoline-6-sulphonate (ABTS(+)) and hydroxyl (OH) free radicals. Among SPCs, quercetin and kaempferol, as typical flavonoids, displayed the greatest radical-scavenging activities and even exhibited higher activity in OH radical removal ability than that of Vc...
July 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28242577/risk-of-second-primary-cancer-associated-with-pre-diagnostic-smoking-alcohol-and-obesity-in-women-with-keratinocyte-carcinoma
#10
Sang Min Park, Tricia Li, Shaowei Wu, Wen-Qing Li, Abrar A Qureshi, Meir Stampfer, Eunyoung Cho
Keratinocyte carcinoma (KC), which includes basal-cell carcinoma (BCC) and squamous-cell cancer (SCC), has been associated with an increased risk of second primary cancers (SPCs), although the reason for this increase is unknown. We assessed the effects of smoking, alcohol, and obesity prior to the diagnosis of KC on the development of SPCs, as these are well-established risk factors for multiple cancers and may also contribute to the increased risk of SPCs among those with KC. A total of 15,628 women with self-reported KC were identified in the Nurses' Health Study...
February 24, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28210920/choosing-the-appropriate-side-for-subcutaneous-port-catheter-placement-in-patients-with-mastectomy-ipsilateral-or-contralateral
#11
Omer Fatih Nas, Kadir Hacikurt, Ahmet Kaya, Nurullah Dogan, Bekir Sanal, Guven Ozkaya, Halit Ziya Dundar, Cuneyt Erdogan
PURPOSE: To evaluate long-term clinical follow-up results of implanting subcutaneous port catheters (SPCs) on ipsilateral or contralateral with mastectomy side in patients with axillary lymph node dissection. METHODS: A total of 73 patients composed of ipsilateral (34 catheters) and contralateral (39 catheters) groups, with SPCs were included. All patients had lumpectomy or modified radical mastectomy for breast cancer. Ipsilateral and contralateral groups had similar patient characteristics...
June 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28195265/solid-papillary-carcinoma-of-the-nipple-an-in-situ-carcinoma-or-an-expansive-growth-tumor
#12
D Tacchini, L Vassallo, M A G M Butorano, V Mancini, T Megha
Papillary breast lesions are a heterogeneous group of tumors which mainly arise in the central mammary region, ranging from benign to malignant. Among them, solid papillary carcinoma (SPC) represents a very uncommon variant with indolent clinical behavior and excellent prognosis. The categorization of papillary lesions as benign, atypical or malignant is often difficult even for experienced pathologists. Furthermore, for prognostic purposes, to decide whether to consider a lesions as in situ when it is not associated with frank invasive foci of carcinoma may be problematic...
September 2016: Pathologica
https://www.readbyqxmd.com/read/28147539/tuning-flexibility-to-control-selectivity-in-soft-porous-crystals
#13
Nathan A Mahynski, Vincent K Shen
We use flat-histogram Monte Carlo simulations to study how changing the flexibility of soft porous crystals (SPCs) affects their selective adsorption of a binary, size-asymmetric supercritical fluid. Specifically, we consider mesoporous SPCs which have multiple minima in their free energy profiles as a function of pore size such that they are capable of exhibiting polymorphism between a narrow and large pore phase. While specific fluid-pore interactions determine the shape of both pores' selectivity curve as a function of adsorbate pressure, an individual pore tends to selectively adsorb a species based on the size of the adsorbate molecule relative to itself, thereby shifting the pore's selectivity curve relative to its polymorph...
January 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28088030/efficacy-and-safety-of-linagliptin-metformin-single-pill-combination-as-initial-therapy-in-drug-na%C3%A3-ve-asian-patients-with-type-2-diabetes
#14
RANDOMIZED CONTROLLED TRIAL
Yiming Mu, Changyu Pan, Bei Fan, Uwe Hehnke, Xiuzhen Zhang, Xuejun Zhang, Xiaoyue Wang, Jingdong Liu, Ying Zhang, Jianling Du, Jianhua Ma, Yan Gong
AIM: To assess efficacy/safety of initial linagliptin/metformin single-pill combination (SPC) therapies versus individual drug components over 24weeks in treatment-naïve Asian patients with type 2 diabetes mellitus and insufficient glycemic control. METHODS: Patients (initial glycated hemoglobin [HbA1c] ⩾7.5% to <11.0% [58-97mmol/mol]; main group) were randomized to: linagliptin 5mg once daily (qd); metformin 500mg twice daily (bid); metformin 1000mg bid; linagliptin 2...
February 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28075064/efficacy-of-nebivolol-valsartan-single-pill-combination-in-obese-and-nonobese-patients-with-hypertension
#15
Christian W Mende, Thomas D Giles, David B Bharucha, William G Ferguson, Madhuja Mallick, Mehul D Patel
Antihypertensive efficacy of single-pill combinations (SPCs) consisting of a β1 -selective adrenergic blocker with vasodilatory properties via β3 -agonism (nebivolol) and an angiotensin II receptor blocker (valsartan) was demonstrated in an 8-week phase 3 trial (NCT01508026). In this post hoc analysis, seated blood pressure, heart rate, 24-hour ambulatory blood pressure monitoring, plasma aldosterone, estimated glomerular filtration rate, and safety measures were assessed in obese (body mass index >32 kg/m(2) ; n=1823) and nonobese (body mass index <27 kg/m(2) ; n=847) adults with hypertension (stage I or II) treated with nebivolol-valsartan SPCs, nebivolol or valsartan monotherapy, or placebo...
January 11, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28072843/chemokine-ligand-5-ccl5-derived-from-endothelial-colony-forming-cells-ecfcs-mediates-recruitment-of-smooth-muscle-progenitor-cells-spcs-toward-critical-vascular-locations-in-moyamoya-disease
#16
Ji Hoon Phi, Naoko Suzuki, Youn Joo Moon, Ae Kyung Park, Kyu-Chang Wang, Ji Yeoun Lee, Seung-Ah Choi, Sangjoon Chong, Reizo Shirane, Seung-Ki Kim
The etiology and pathogenesis of moyamoya disease (MMD) are still obscure. Previous studies indicated that angiogenic chemokines may play an important role in the pathogenesis of the disease. Recently, it was discovered that peripheral blood-derived endothelial colony-forming cells (ECFCs) and smooth muscle progenitor cells (SPCs) have defective functions in MMD patients. Therefore, the interaction of ECFCs and SPCs, the precursors of two crucial cellular components of vascular walls, with some paracrine molecules is an intriguing subject...
2017: PloS One
https://www.readbyqxmd.com/read/28001312/critical-re-appraisal-of-blood-component-quality-after-overnight-hold-of-whole-blood-outside-current-room-temperature-limits
#17
I J Bontekoe, P F van der Meer, D de Korte
BACKGROUND AND OBJECTIVES: According to European guidelines, the temperature of whole blood (WB) has to be maintained at 20-24°C until processing within 24 h, but in blood bank practice, WB is frequently held at temperatures between 18-25°C. We aimed to assess the impact of these small temperature deviations on the quality of the blood components. MATERIALS AND METHODS: After rapid cooling, 7 WB units were held overnight at 18°C and 8 units at 25°C, reflecting worst case holding conditions, and separated into a red cell concentrate (RCC), plasma and buffy coat (BC)...
February 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/27918856/preliminary-investigation-into-sport-and-exercise-psychology-consultants-views-and-experiences-of-an-interprofessional-care-team-approach-to-sport-injury-rehabilitation
#18
Monna Arvinen-Barrow, Damien Clement
Sport injury rehabilitation has moved from predominately physical treatment to a more holistic care. However, limited research has explored the views and experiences of those involved in such an approach. The purpose of this study was to preliminarily investigate sport psychology consultants' (SPCs') views and experiences of an interprofessional team approach to sport injury rehabilitation. A cross-sectional online survey previously used with athletic trainers was distributed via a US-based sport/exercise psychology list-serve (N = 1245)...
January 2017: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/27866674/quantitative-t2-mapping-for-detection-and-quantification-of-thrombophlebitis-in-a-rabbit-model
#19
Dar Weiss, Oren M Rotman, Shmuel Einav
Short peripheral catheter thrombophlebitis (SPCT), a sterile inflammation of the vein wall, is the most common complication associated with short peripheral catheters (SPCs) and affects up to 80% of hospitalized patients receiving IV therapy. Extensive research efforts have been devoted for improvement and optimization of the catheter material, but means for examination of any novel design are limited, inaccurate and require costly comprehensive pre-clinical and clinical trials. Therefore, there is a conclusive need for a reliable quantitative method for evaluation of SPCT, in particular for research purposes examining the thrombophlebitis-related symptoms of any novel catheter design...
January 4, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/27863195/prediagnosis-body-mass-index-and-risk-of-secondary-primary-cancer-in-male-cancer-survivors-a-large-cohort-study
#20
Sang Min Park, Young Ho Yun, Young Ae Kim, Minkyung Jo, Young-Joo Won, Joung Hwan Back, Eun-Sook Lee
Purpose Male cancer survivors have a higher risk of cancer than the general population, which might be caused by an increased prevalence of obesity or susceptibility to obesity-related carcinogenesis. We assessed the effects of obesity before the diagnosis of a first cancer on the development of secondary primary cancers (SPCs). Methods The study population consisted of 239,615 Korean male cancer survivors between January 2003 and December 2010. Incident SPCs were assessed throughout follow-up until December 2011...
December 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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