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https://www.readbyqxmd.com/read/27918856/preliminary-investigation-into-sport-and-exercise-psychology-consultants-views-and-experiences-of-an-interprofessional-care-team-approach-to-sport-injury-rehabilitation
#1
Monna Arvinen-Barrow, Damien Clement
Sport injury rehabilitation has moved from predominately physical treatment to a more holistic care. However, limited research has explored the views and experiences of those involved in such an approach. The purpose of this study was to preliminarily investigate sport psychology consultants' (SPCs') views and experiences of an interprofessional team approach to sport injury rehabilitation. A cross-sectional online survey previously used with athletic trainers was distributed via a US-based sport/exercise psychology list-serve (N = 1245)...
December 5, 2016: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/27866674/quantitative-t2-mapping-for-detection-and-quantification-of-thrombophlebitis-in-a-rabbit-model
#2
Dar Weiss, Oren M Rotman, Shmuel Einav
Short peripheral catheter thrombophlebitis (SPCT), a sterile inflammation of the vein wall, is the most common complication associated with short peripheral catheters (SPCs) and affects up to 80% of hospitalized patients receiving IV therapy. Extensive research efforts have been devoted for improvement and optimization of the catheter material, but means for examination of any novel design are limited, inaccurate and require costly comprehensive pre-clinical and clinical trials. Therefore, there is a conclusive need for a reliable quantitative method for evaluation of SPCT, in particular for research purposes examining the thrombophlebitis-related symptoms of any novel catheter design...
November 15, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27863195/prediagnosis-body-mass-index-and-risk-of-secondary-primary-cancer-in-male-cancer-survivors-a-large-cohort-study
#3
Sang Min Park, Young Ho Yun, Young Ae Kim, Minkyung Jo, Young-Joo Won, Joung Hwan Back, Eun-Sook Lee
Purpose Male cancer survivors have a higher risk of cancer than the general population, which might be caused by an increased prevalence of obesity or susceptibility to obesity-related carcinogenesis. We assessed the effects of obesity before the diagnosis of a first cancer on the development of secondary primary cancers (SPCs). Methods The study population consisted of 239,615 Korean male cancer survivors between January 2003 and December 2010. Incident SPCs were assessed throughout follow-up until December 2011...
December 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27796904/strategies-for-diabetes-management-using-newer-oral-combination-therapies-early-in-the-disease
#4
REVIEW
Joel Zonszein, Per-Henrik Groop
INTRODUCTION: The duration of uncontrolled type 2 diabetes mellitus (T2DM) can adversely impact small and large vessels, eventually leading to microvascular and macrovascular complications. Failure of therapeutic lifestyle changes, monotherapy, and clinical inertia contribute to persistent hyperglycemia and disease progression. The aim was to review the complex pathophysiology of type 2 diabetes and how different oral agents can be used effectively as first-line therapy in combination with metformin, as well as in patients not achieving glycemic goals with metformin therapy...
December 2016: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/27783469/clinical-features-and-treatment-outcomes-of-japanese-head-and-neck-cancer-patients-with-a-second-primary-cancer
#5
Taku Yamashita, Koji Araki, Masayuki Tomifuji, Yuya Tanaka, Eiko Harada, Tatsutoshi Suzuki, Shunsuke Miyamoto, Akihiro Shiotani
AIM: It has been well established that patients with head and neck cancer (HNC) have an elevated risk of developing a second primary cancer (SPC), owing to the common carcinogenic risk factors, including tobacco and alcohol consumption, and inactive aldehyde dehydrogenase-2 genotype. Here we investigated the current state of SPC in Japanese HNC patients. METHODS: We retrospectively investigated the incidence and treatment outcomes of synchronous and metachronous SPCs among 434 newly diagnosed HNC patients...
October 26, 2016: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27780335/a-randomized-trial-of-dialectical-behavior-therapy-in-high-risk-suicidal-veterans
#6
Marianne Goodman, David Banthin, Nicholas J Blair, Kathryn A Mascitelli, Jaime Wilsnack, Jennifer Chen, Julie W Messenger, M Mercedes Perez-Rodriguez, Joseph Triebwasser, Harold W Koenigsberg, Raymond R Goetz, Erin A Hazlett, Antonia S New
OBJECTIVE: Despite advances in suicide prevention implemented throughout the US Department of Veterans Affairs (VA) including the hiring of Suicide Prevention Coordinators (SPCs) at every VA hospital, enhanced monitoring, and the availability of 24-hour crisis hotline services, suicide by veterans remains a critical problem affecting 20 veterans daily. Few empirically based treatment strategies for suicide prevention for postdeployment military personnel exist. This study aimed to test whether dialectical behavior therapy (DBT), one of the few psychosocial treatments with proven efficacy in diminishing suicidal behavior in individuals with personality disorder, can be applied to veterans irrespective of personality diagnosis...
October 25, 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27750346/-medication-management-simvastatin-and-amlodipin-a-clinically-relevant-drug-interaction
#7
Jane Schröder, Lisa Goltz, Holger Knoth
The clinical relevance of the drug-drug interaction simvastatin and amlodipine is appraised controversially by german simvastatin Summary of Product Characteristics (SPCs) and different drug interaction databases. Results of clinical trials have shown that simultaneous administration of simvastatin and amlodipine can increase simvastatin bioavailability. However, it is unclear whether this increase is associated with a higher risk for adverse drug events. So far there is no evidence that the combination might increase cases of myopathy or rhabdomyolysis...
October 2016: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27747834/real-life-effectiveness-and-safety-of-amlodipine-valsartan-single-pill-combination-in-patients-with-hypertension-in-egypt-results-from-the-excite-study
#8
Samir H Assaad-Khalil, Nashwa Nashaat
BACKGROUND: EXCITE (clinical experience of amlodipine and valsartan in hypertension) evaluated the real-world effectiveness and safety of single-pill combinations (SPCs) of amlodipine/valsartan (Aml/Val) and amlodipine/valsartan/hydrochlorothiazide (Aml/Val/HCTZ) in patients with hypertension from the Middle East and Asia. OBJECTIVE: The objective of this study was to report the results of EXCITE study from Egypt, where all patients were prescribed Aml/Val. METHODS: This was a 26-week, observational, multicenter, prospective, non-interventional, open-label study...
September 2016: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/27734632/is-there-a-role-for-igf-1-in-the-development-of-second-primary-cancers
#9
REVIEW
Thurkaa Shanmugalingam, Cecilia Bosco, Anne J Ridley, Mieke Van Hemelrijck
Cancer survival rates are increasing, and as a result, more cancer survivors are exposed to the risk of developing a second primary cancer (SPC). It has been hypothesized that one of the underlying mechanisms for this risk could be mediated by variations in insulin-like growth factor-1 (IGF-1). This review summarizes the current epidemiological evidence to identify whether IGF-1 plays a role in the development of SPCs. IGF-1 is known to promote cancer development by inhibiting apoptosis and stimulating cell proliferation...
November 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27685179/adverse-events-in-children-and-adolescents-treated-with-quetiapine-an-analysis-of-adverse-drug-reaction-reports-from-the-danish-medicines-agency-database
#10
Klaus D Jakobsen, Helle Wallach-Kildemoes, Christina H Bruhn, Nasseh Hashemi, Anne K Pagsberg, Anders Fink-Jensen, Jimmi Nielsen
Quetiapine is a low-affinity dopamine D2 receptor antagonist, approved for the treatment of bipolar disorder and schizophrenia in children and adolescents by the Food and Drug Administration, but not by European Medicine Agency. Although knowledge of adverse drug reactions in children and adolescents is scarce, quetiapine is increasingly being used for youth in Denmark. The aim of this case study is to discuss adverse drug events (ADEs) spontaneously reported to the Danish Medicines Agency on quetiapine used in the pediatric population in relation to adversive drug reactions (ADRs) reported in the European Summary of Product Characteristics (SPCs)...
September 28, 2016: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27670208/fast-track-systems-improve-timely-carotid-endarterectomy-in-stroke-prevention-outpatients
#11
Sophia Gocan, Aline Bourgoin, Dylan Blacquiere, Rany Shamloul, Dar Dowlatshahi, Grant Stotts
BACKGROUND: For optimal stroke prevention, best practices guidelines recommend carotid endarterectomy (CEA) for symptomatic patients within two weeks; however, 2013 Ontario data indicated that only 9% of eligible patients from outpatient Stroke Prevention Clinics (SPCs) achieved this target. The goal of our study was to identify modifiable system factors that could enhance the quality and timeliness of care among patients needing urgent CEA. METHODS: We conducted a retrospective chart review of transient ischemic attack/stroke patients assessed in Champlain Local Health Integrated Network SPCs between 2011 and 2014 who subsequently underwent CEA...
September 2016: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/27668717/porous-cellulose-spheres-preparation-modification-and-adsorption-properties
#12
Xiaofei Ma, Congzhi Liu, Debbie P Anderson, Peter R Chang
Porous cellulose spheres (PCS) were fabricated by precipitating the spheres from a cellulose ionic liquid solution, followed by freezing, solvent exchange, and drying. PCS had low crystallinity and a large surface area that facilitated modification with trisodium trimetaphosphate (STMP) to introduce phosphate ester groups into the porous structure of the heterogeneous system. The STMP-modified PCS (SPCS) were used to remove heavy metal ions from aqueous solution. With increasing STMP dosage, the adsorption capacity of SPCS obviously improved due to chelation between Pb(2+) and phosphate ester groups...
December 2016: Chemosphere
https://www.readbyqxmd.com/read/27617314/second-primary-cancers-in-patients-with-urothelial-cancers
#13
Ali Feyzullah Şahin, Muammer Altok, Fırat Akdeniz, Güner Yıldız, Rauf Taner Divrik
PURPOSE: To investigate the second primary cancers (SPCs) in patients with urothelial cancer (UC). MATERIALS AND METHODS: The records of 2,339 patients whose UC was diagnosed between January 1974 and December 2012 were reviewed. All data about characteristics of patients, of UC and, of SPC was, recorded digitally. We investigated the prevalence and the type of second or higher order cancers, and the factors associated with SPC. RESULTS: Total 260 patients (11...
September 2016: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/27577400/automatic-extraction-of-drug-adverse-effects-from-product-characteristics-spcs-a-text-versus-table-comparison
#14
Jean-Baptiste Lamy, Adrien Ugon, Hélène Berthelot
BACKGROUND: Potential adverse effects (AEs) of drugs are described in their summary of product characteristics (SPCs), a textual document. Automatic extraction of AEs from SPCs is useful for detecting AEs and for building drug databases. However, this task is difficult because each AE is associated with a frequency that must be extracted and the presentation of AEs in SPCs is heterogeneous, consisting of plain text and tables in many different formats. METHODS: We propose a taxonomy for the presentation of AEs in SPCs...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27559288/the-reliability-and-validity-of-the-saliba-postural-classification-system
#15
Cristiana Kahl Collins, Vicky Saliba Johnson, Ellen M Godwin, Evangelos Pappas
OBJECTIVES: To determine the reliability and validity of the Saliba Postural Classification System (SPCS). METHODS: Two physical therapists classified pictures of 100 volunteer participants standing in their habitual posture for inter and intra-tester reliability. For validity, 54 participants stood on a force plate in a habitual and a corrected posture, while a vertical force was applied through the shoulders until the clinician felt a postural give. Data were extracted at the time the give was felt and at a time in the corrected posture that matched the peak vertical ground reaction force (VGRF) in the habitual posture...
July 2016: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/27525634/efficacy-of-double-scope-endoscopic-submucosal-dissection-and-long-term-outcomes-of-endoscopic-resection-for-superficial-pharyngeal-carcinomas
#16
Toshiyuki Yoshio, Tomohiro Tsuchida, Akiyoshi Ishiyama, Masami Omae, Toshiaki Hirasawa, Yorimasa Yamamoto, Junko Fujisaki, Yukiko Sato, Tohru Sasaki, Kazuyoshi Kawabata, Masahiro Igarashi
OBJECTIVES: Owing to increased awareness and the use of narrow band imaging, there are more opportunities to treat superficial pharyngeal cancer (SPC). This study aimed to describe the short- and long-term outcomes of ER (endoscopic resection) for SPC. METHODS: This study included 166 consecutive SPCs in 113 patients treated during 2006-2013 at one referral cancer center. In the first period, we treated patients using endoscopic mucosal resection (EMR), in the second period using conventional ESD (cESD) and in the recent period using double-scope ESD (dsESD), which involves a second thin endoscope for assistance to produce traction...
August 15, 2016: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/27489499/the-involving-roles-of-intrahepatic-and-extrahepatic-stem-progenitor-cells-spcs-to-liver-regeneration
#17
REVIEW
Wei-Hui Liu, Li-Na Ren, Tao Wang, Nalu Navarro-Alvarez, Li-Jun Tang
Liver regeneration is usually attributed to mature hepatocytes, which possess a remarkable potential to proliferate under mild to moderate injury. However, when the liver is severely damaged or hepatocyte proliferation is greatly inhibited, liver stem/progenitor cells (LSPCs) will contribute to the liver regeneration process. LSPCs in the developing liver have been extensively characterized, however, their contributing role to liver regeneration has not been completely understood. In addition to the restoration of the liver parenchymal tissue by hepatocytes or/and LSPCs, or in some cases bone marrow (BM) derived cells, such as hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs), the wound healing after injury in terms of angiopoiesis by liver sinusoidal endothelial cells (LSECs) or/and sinusoidal endothelial progenitor cells (SEPCs) is another important aspect taking place during regeneration...
2016: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/27486409/imitated-prosodic-fluency-predicts-reading-comprehension-ability-in-good-and-poor-high-school-readers
#18
Mara Breen, Lianne Kaswer, Julie A Van Dyke, Jelena Krivokapić, Nicole Landi
Researchers have established a relationship between beginning readers' silent comprehension ability and their prosodic fluency, such that readers who read aloud with appropriate prosody tend to have higher scores on silent reading comprehension assessments. The current study was designed to investigate this relationship in two groups of high school readers: Specifically Poor Comprehenders (SPCs), who have adequate word level and phonological skills but poor reading comprehension ability, and a group of age- and decoding skill-matched controls...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27438988/clinicopathologic-characteristics-of-solid-papillary-carcinoma-of-the-breast
#19
Benjamin Yongcheng Tan, Aye Aye Thike, Ian O Ellis, Puay Hoon Tan
Solid papillary carcinoma (SPC) of the breast is defined as a "distinctive form of papillary carcinoma characterized by closely apposed expansive, cellular nodules." This uncommon tumor frequently demonstrates neuroendocrine differentiation. SPCs are staged as in situ tumors, except those that exhibit jagged borders within desmoplastic stroma, or if accompanied by conventional invasive carcinoma, which is separately graded and staged. In this study, we review the immunomorphologic characteristics of SPCs diagnosed at our institution, with a view toward elucidating points of distinction from other mammary carcinomas that manifest neuroendocrine differentiation...
October 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27383988/a-crispr-screen-defines-a-signal-peptide-processing-pathway-required-by-flaviviruses
#20
Rong Zhang, Jonathan J Miner, Matthew J Gorman, Keiko Rausch, Holly Ramage, James P White, Adam Zuiani, Ping Zhang, Estefania Fernandez, Qiang Zhang, Kimberly A Dowd, Theodore C Pierson, Sara Cherry, Michael S Diamond
Flaviviruses infect hundreds of millions of people annually, and no antiviral therapy is available. We performed a genome-wide CRISPR/Cas9-based screen to identify host genes that, when edited, resulted in reduced flavivirus infection. Here, we validated nine human genes required for flavivirus infectivity, and these were associated with endoplasmic reticulum functions including translocation, protein degradation, and N-linked glycosylation. In particular, a subset of endoplasmic reticulum-associated signal peptidase complex (SPCS) proteins was necessary for proper cleavage of the flavivirus structural proteins (prM and E) and secretion of viral particles...
July 7, 2016: Nature
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