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Jane Schröder, Lisa Goltz, Holger Knoth
The clinical relevance of the drug-drug interaction simvastatin and amlodipine is appraised controversially by german simvastatin Summary of Product Characteristics (SPCs) and different drug interaction databases. Results of clinical trials have shown that simultaneous administration of simvastatin and amlodipine can increase simvastatin bioavailability. However, it is unclear whether this increase is associated with a higher risk for adverse drug events. So far there is no evidence that the combination might increase cases of myopathy or rhabdomyolysis...
October 2016: Deutsche Medizinische Wochenschrift
Samir H Assaad-Khalil, Nashwa Nashaat
BACKGROUND: EXCITE (clinical experience of amlodipine and valsartan in hypertension) evaluated the real-world effectiveness and safety of single-pill combinations (SPCs) of amlodipine/valsartan (Aml/Val) and amlodipine/valsartan/hydrochlorothiazide (Aml/Val/HCTZ) in patients with hypertension from the Middle East and Asia. OBJECTIVE: The objective of this study was to report the results of EXCITE study from Egypt, where all patients were prescribed Aml/Val. METHODS: This was a 26-week, observational, multicenter, prospective, non-interventional, open-label study...
September 2016: Drugs—Real World Outcomes
Thurkaa Shanmugalingam, Cecilia Bosco, Anne J Ridley, Mieke Van Hemelrijck
Cancer survival rates are increasing, and as a result, more cancer survivors are exposed to the risk of developing a second primary cancer (SPC). It has been hypothesized that one of the underlying mechanisms for this risk could be mediated by variations in insulin-like growth factor-1 (IGF-1). This review summarizes the current epidemiological evidence to identify whether IGF-1 plays a role in the development of SPCs. IGF-1 is known to promote cancer development by inhibiting apoptosis and stimulating cell proliferation...
October 13, 2016: Cancer Medicine
Klaus D Jakobsen, Helle Wallach-Kildemoes, Christina H Bruhn, Nasseh Hashemi, Anne K Pagsberg, Anders Fink-Jensen, Jimmi Nielsen
Quetiapine is a low-affinity dopamine D2 receptor antagonist, approved for the treatment of bipolar disorder and schizophrenia in children and adolescents by the Food and Drug Administration, but not by European Medicine Agency. Although knowledge of adverse drug reactions in children and adolescents is scarce, quetiapine is increasingly being used for youth in Denmark. The aim of this case study is to discuss adverse drug events (ADEs) spontaneously reported to the Danish Medicines Agency on quetiapine used in the pediatric population in relation to adversive drug reactions (ADRs) reported in the European Summary of Product Characteristics (SPCs)...
September 28, 2016: International Clinical Psychopharmacology
Sophia Gocan, Aline Bourgoin, Dylan Blacquiere, Rany Shamloul, Dar Dowlatshahi, Grant Stotts
BACKGROUND: For optimal stroke prevention, best practices guidelines recommend carotid endarterectomy (CEA) for symptomatic patients within two weeks; however, 2013 Ontario data indicated that only 9% of eligible patients from outpatient Stroke Prevention Clinics (SPCs) achieved this target. The goal of our study was to identify modifiable system factors that could enhance the quality and timeliness of care among patients needing urgent CEA. METHODS: We conducted a retrospective chart review of transient ischemic attack/stroke patients assessed in Champlain Local Health Integrated Network SPCs between 2011 and 2014 who subsequently underwent CEA...
September 2016: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
Xiaofei Ma, Congzhi Liu, Debbie P Anderson, Peter R Chang
Porous cellulose spheres (PCS) were fabricated by precipitating the spheres from a cellulose ionic liquid solution, followed by freezing, solvent exchange, and drying. PCS had low crystallinity and a large surface area that facilitated modification with trisodium trimetaphosphate (STMP) to introduce phosphate ester groups into the porous structure of the heterogeneous system. The STMP-modified PCS (SPCS) were used to remove heavy metal ions from aqueous solution. With increasing STMP dosage, the adsorption capacity of SPCS obviously improved due to chelation between Pb(2+) and phosphate ester groups...
December 2016: Chemosphere
Ali Feyzullah Şahin, Muammer Altok, Fırat Akdeniz, Güner Yıldız, Rauf Taner Divrik
PURPOSE: To investigate the second primary cancers (SPCs) in patients with urothelial cancer (UC). MATERIALS AND METHODS: The records of 2,339 patients whose UC was diagnosed between January 1974 and December 2012 were reviewed. All data about characteristics of patients, of UC and, of SPC was, recorded digitally. We investigated the prevalence and the type of second or higher order cancers, and the factors associated with SPC. RESULTS: Total 260 patients (11...
September 2016: Investigative and Clinical Urology
Jean-Baptiste Lamy, Adrien Ugon, Hélène Berthelot
BACKGROUND: Potential adverse effects (AEs) of drugs are described in their summary of product characteristics (SPCs), a textual document. Automatic extraction of AEs from SPCs is useful for detecting AEs and for building drug databases. However, this task is difficult because each AE is associated with a frequency that must be extracted and the presentation of AEs in SPCs is heterogeneous, consisting of plain text and tables in many different formats. METHODS: We propose a taxonomy for the presentation of AEs in SPCs...
2016: Studies in Health Technology and Informatics
Cristiana Kahl Collins, Vicky Saliba Johnson, Ellen M Godwin, Evangelos Pappas
OBJECTIVES: To determine the reliability and validity of the Saliba Postural Classification System (SPCS). METHODS: Two physical therapists classified pictures of 100 volunteer participants standing in their habitual posture for inter and intra-tester reliability. For validity, 54 participants stood on a force plate in a habitual and a corrected posture, while a vertical force was applied through the shoulders until the clinician felt a postural give. Data were extracted at the time the give was felt and at a time in the corrected posture that matched the peak vertical ground reaction force (VGRF) in the habitual posture...
July 2016: Journal of Manual & Manipulative Therapy
Toshiyuki Yoshio, Tomohiro Tsuchida, Akiyoshi Ishiyama, Masami Omae, Toshiaki Hirasawa, Yorimasa Yamamoto, Junko Fujisaki, Yukiko Sato, Tohru Sasaki, Kazuyoshi Kawabata, Masahiro Igarashi
OBJECTIVES: Owing to increased awareness and the use of narrow band imaging, there are more opportunities to treat superficial pharyngeal cancer (SPC). This study aimed to describe the short- and long-term outcomes of ER (endoscopic resection) for SPC. METHODS: This study included 166 consecutive SPCs in 113 patients treated during 2006-2013 at one referral cancer center. In the first period, we treated patients using endoscopic mucosal resection (EMR), in the second period using conventional ESD (cESD) and in the recent period using double-scope ESD (dsESD), which involves a second thin endoscope for assistance to produce traction...
August 15, 2016: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
Wei-Hui Liu, Li-Na Ren, Tao Wang, Nalu Navarro-Alvarez, Li-Jun Tang
Liver regeneration is usually attributed to mature hepatocytes, which possess a remarkable potential to proliferate under mild to moderate injury. However, when the liver is severely damaged or hepatocyte proliferation is greatly inhibited, liver stem/progenitor cells (LSPCs) will contribute to the liver regeneration process. LSPCs in the developing liver have been extensively characterized, however, their contributing role to liver regeneration has not been completely understood. In addition to the restoration of the liver parenchymal tissue by hepatocytes or/and LSPCs, or in some cases bone marrow (BM) derived cells, such as hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs), the wound healing after injury in terms of angiopoiesis by liver sinusoidal endothelial cells (LSECs) or/and sinusoidal endothelial progenitor cells (SEPCs) is another important aspect taking place during regeneration...
2016: International Journal of Biological Sciences
Mara Breen, Lianne Kaswer, Julie A Van Dyke, Jelena Krivokapić, Nicole Landi
Researchers have established a relationship between beginning readers' silent comprehension ability and their prosodic fluency, such that readers who read aloud with appropriate prosody tend to have higher scores on silent reading comprehension assessments. The current study was designed to investigate this relationship in two groups of high school readers: Specifically Poor Comprehenders (SPCs), who have adequate word level and phonological skills but poor reading comprehension ability, and a group of age- and decoding skill-matched controls...
2016: Frontiers in Psychology
Benjamin Yongcheng Tan, Aye Aye Thike, Ian O Ellis, Puay Hoon Tan
Solid papillary carcinoma (SPC) of the breast is defined as a "distinctive form of papillary carcinoma characterized by closely apposed expansive, cellular nodules." This uncommon tumor frequently demonstrates neuroendocrine differentiation. SPCs are staged as in situ tumors, except those that exhibit jagged borders within desmoplastic stroma, or if accompanied by conventional invasive carcinoma, which is separately graded and staged. In this study, we review the immunomorphologic characteristics of SPCs diagnosed at our institution, with a view toward elucidating points of distinction from other mammary carcinomas that manifest neuroendocrine differentiation...
October 2016: American Journal of Surgical Pathology
Rong Zhang, Jonathan J Miner, Matthew J Gorman, Keiko Rausch, Holly Ramage, James P White, Adam Zuiani, Ping Zhang, Estefania Fernandez, Qiang Zhang, Kimberly A Dowd, Theodore C Pierson, Sara Cherry, Michael S Diamond
Flaviviruses infect hundreds of millions of people annually, and no antiviral therapy is available. We performed a genome-wide CRISPR/Cas9-based screen to identify host genes that, when edited, resulted in reduced flavivirus infection. Here, we validated nine human genes required for flavivirus infectivity, and these were associated with endoplasmic reticulum functions including translocation, protein degradation, and N-linked glycosylation. In particular, a subset of endoplasmic reticulum-associated signal peptidase complex (SPCS) proteins was necessary for proper cleavage of the flavivirus structural proteins (prM and E) and secretion of viral particles...
July 7, 2016: Nature
Alexandre M C Santos, Loredana G Marcu, Chia M Wong, Eva Bezak
AIMS: There is evidence towards the induction of second primary cancers (SPCs) after breast radiotherapy (RT). Organs, such as the lungs and the esophagus, have been identified as common sites for SPC formation. As a result, the current study investigated the risk of secondary carcinogenesis associated with particular RT techniques for breast cancer; including whole breast, segmented breast, partial breast and mammosite brachytherapy. METHODS: In this study, seven breast cancer patients had all major organs contoured on their planning computed tomography (CT) images...
July 5, 2016: Acta Oncologica
Florent Neumann, Jérémie Jégu, Christiane Mougin, Jean-Luc Prétet, Anne-Valérie Guizard, Bénédicte Lapôtre-Ledoux, Simona Bara, Véronique Bouvier, Marc Colonna, Xavier Troussard, Brigitte Trétarre, Pascale Grosclaude, Michel Velten, Anne-Sophie Woronoff
Human papillomaviruses (HPV) are involved in the development of anogenital and head and neck cancers. The purpose of this study was to assess the risk of developing a second primary cancer (SPC) after a first potentially-HPV-related cancer, and to analyze the sites where SPCs most frequently occurred in these patients. All patients with a first cancer diagnosed between 1989 and 2004, as recorded by 10 French cancer registries, were followed up until December 31, 2007. Only invasive potentially-HPV-related cancers (namely, cervical, vagina, vulva, anal canal, penile, oropharynx, tongue and tonsil) were included...
September 2016: Preventive Medicine
Hong Soon Kang, Liang-Yu Chen, Kristin Lichti-Kaiser, Grace Liao, Kevin Gerrish, Carl D Bortner, Humphrey H-C Yao, Edward M Eddy, Anton M Jetten
In this study, we identify a novel and essential role for the Krüppel-like zinc finger transcription factor GLIS3 in the regulation of postnatal spermatogenesis. We show that GLIS3 is expressed in gonocytes, spermatogonial stem cells (SSCs) and spermatogonial progenitors (SPCs), but not in differentiated spermatogonia and later stages of spermatogenesis or in somatic cells. Spermatogenesis is greatly impaired in GLIS3 knockout mice. Loss of GLIS3 function causes a moderate reduction in the number of gonocytes, but greatly affects the generation of SSCs/SPCs, and as a consequence the development of spermatocytes...
June 28, 2016: Stem Cells
Tianhui Chen, Elham Kharazmi, Jianlin Lou, Xing Zhang, Kristina Sundquist, Kari Hemminki
We aimed at investigating risk of specific second primary cancers (SPCs) after malignant mesothelioma (MM) and vice versa, which has not been reported. Among survivors of 3672 pleural MM and 895 peritoneal MM, overall 113 and 28 SPCs were recorded, respectively, while reverse analyses included overall 431 pleural and 88 peritoneal MMs after any first cancers. We found a bidirectional association of pleural MM with kidney cancer for overall [for second kidney cancer after pleural MM: standardized incidence ratios (SIRs) = 4...
August 28, 2016: Cancer Letters
Rebecca A Zakrajsek, Scott B Martin, Craig A Wrisberg
CONTEXT: Certified athletic trainers (ATs) are responsible for integrating relevant professionals into the rehabilitation team to assist with the holistic care of injured athletes. OBJECTIVE: To explore National Collegiate Athletic Association Division I (DI) ATs' experience with sport psychology consultants (SPCs), willingness to encourage athletes to use SPCs for injury rehabilitation, and perceptions of the benefits of sport psychology services. DESIGN: Quantitative study...
May 2016: Journal of Athletic Training
Nana Dupont, Mette Fertner, Charlotte Sonne Kristensen, Nils Toft, Helle Stege
BACKGROUND: Transparent calculation methods are crucial when investigating trends in antimicrobial consumption over time and between populations. Until 2011, one single standardized method was applied when quantifying the Danish pig antimicrobial consumption with the unit "Animal Daily Dose" (ADD). However, two new methods for assigning values for ADDs have recently emerged, one implemented by DANMAP, responsible for publishing annual reports on antimicrobial consumption, and one by the Danish Veterinary and Food Administration (DVFA), responsible for the Yellow Card initiative...
2016: Acta Veterinaria Scandinavica
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