keyword
MENU ▼
Read by QxMD icon Read
search

signal peptidase

keyword
https://www.readbyqxmd.com/read/29772527/a-novel-role-for-cd26-dipeptidyl-peptidase-iv-as-a-therapeutic-target
#1
Kei Ohnuma, Ryo Hatano, Eriko Komiya, Haruna Otsuka, Takumi Itoh, Noriaki Iwao, Yutaro Kaneko, Taketo Yamada, Nam H Dang, Chikao Morimoto
CD26 is a 110 kDa surface glycoprotein with intrinsic dipeptidyl peptidase IV activity that is expressed on numerous cell types and has a multitude of biological functions. The role of CD26 in immune regulation has been extensively characterized, with recent findings elucidating its linkage with signaling pathways and structures involved in T-lymphocyte activation as well as antigen presenting cell-T-cell interaction. In this paper, we will review emerging data on CD26-mediated immune regulation suggesting that CD26 may be an appropriate therapeutic target for the treatment of selected immune disorders as well as Middle East respiratory syndrome coronavirus...
June 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/29749454/usp18-promotes-breast-cancer-growth-by-upregulating-egfr-and-activating-the-akt-skp2-pathway
#2
Yawen Tan, Guanglin Zhou, Xianming Wang, Weicai Chen, Haidong Gao
Recent studies have suggested that ubiquitin-specific peptidase (USP)18 may act as an oncogene in various types of cancer. Although the role of USP18 in breast cancer cell lines has been elucidated, the underlying mechanisms and clinical role of USP18 in breast cancer are currently not well understood. The bioinformatics analysis and experimental results of the present study demonstrated that aberrant promoter methylation led to increased expression of USP18 in breast cancer. In addition, correlation analysis suggested that a negative correlation between methylation and USP18 mRNA expression was observed in The Cancer Genome Atlas database...
April 30, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29748603/tspy1-suppresses-usp7-mediated-p53-function-and-promotes-spermatogonial-proliferation
#3
Ying Shen, Wenling Tu, Yunqiang Liu, Xiling Yang, Qiang Dong, Bo Yang, Jinyan Xu, Yuanlong Yan, Xue Pei, Mohan Liu, Wenming Xu, Yuan Yang
Testis-specific protein Y-linked 1 (TSPY1) is expressed predominantly in adult human spermatogonia and functions in the process of spermatogenesis; however, our understanding of the underlying mechanism is limited. Here we observed that TSPY1, as an interacting partner of TSPY-like 5 (TSPYL5), enhanced the competitive binding of TSPYL5 to ubiquitin-specific peptidase 7 (USP7) in conjunction with p53. This activity, together with its promotion of TSPYL5 expression by acting as a transcription factor, resulted in increased p53 ubiquitylation...
May 10, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29735591/the-alchemist-s-nightmare-might-mesenchymal-stem-cells-that-are-recruited-to-repair-the-injured-heart-be-transformed-into-fibroblasts-rather-than-cardiomyocytes
#4
REVIEW
Milton Packer
The injection of mesenchymal stem cells into the injured myocardium to induce cardiac regeneration has yielded disappointing results, conceivably because cells with cardioreparative potential must be supplied for long periods of time to produce a salutary effect. Accordingly, investigators have devised ways of directing such cells to the heart on an ongoing basis: by enhancing the action of endogenous peptides that function as cardiac homing signals (eg, stromal cell-derived factor-1). Stromal cell-derived factor-1 is released during acute cardiac injury and heart failure, but it has a short half-life because of degradation by dipeptidyl peptidase-4...
May 8, 2018: Circulation
https://www.readbyqxmd.com/read/29725682/identification-and-analysis-of-the-cleavage-site-in-a-signal-peptide-using-smote-dagging-and-feature-selection-methods
#5
ShaoPeng Wang, Deling Wang, JiaRui Li, Tao Huang, Yu-Dong Cai
The cleavage site of a signal peptide located in the C-region can be recognized by the signal peptidase in eukaryotic and prokaryotic cells, and the signal peptides are typically cleaved off during or after the translocation of the target protein. The identification of cleavage sites remains challenging because of the diverse lengths of signal peptides and the weak conservation of the motif recognized by the signal peptidase. In this study, we applied a fast and accurate computational method to identify cleavage sites in signal peptides based on protein sequences...
February 12, 2018: Molecular omics
https://www.readbyqxmd.com/read/29724812/usp11-enhances-tgf-946-induced-epithelial-mesenchymal-plasticity-and-human-breast-cancer-metastasis
#6
Daniel A Garcia, Christina Baek, M Valeria Estrada, Tiffani Tysl, Eric J Bennett, Jing Yang, John T Chang
Epithelial-mesenchymal transition (EMT) is a conserved cellular plasticity program that is reactivated in carcinoma cells and drives metastasis. While EMT is well studied its regulatory mechanisms remain unclear. Therefore, to identify novel regulators of EMT, a data mining approach was taken using published microarray data and a group of deubiquitinases (DUBs) were found to be upregulated in cells that have undergone EMT. Here, it is demonstrated that one DUB, ubiquitin specific peptidase 11 (USP11), enhances TGFβ-induced EMT and self-renewal in immortalized human mammary epithelial cells...
May 3, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29715547/anagliptin-inhibits-neointimal-hyperplasia-after-balloon-injury-via-endothelial-cell-specific-modulation-of-sod-1-rhoa-jnk-signaling-in-the-arterial-wall
#7
Qi Li, Mingyu Zhang, Lina Xuan, Yanli Liu, Chang Chen
Intimal hyperplasia is one of the major complications after stenting, but the underlying mechanisms remain unclear. Our previous study found that the dipeptidyl peptidase IV (DPP-4) inhibitor, Anagliptin, suppresses intimal hyperplasia after balloon injury. Here, we further investigated the effects of Anagliptin on endothelial cell (EC) migration after balloon injury. The results showed that Anagliptin administration significantly reduced intimal hyperplasia by stimulating the migration of endothelial cells, but had no effect on the medial area after balloon injury...
April 28, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29697017/high-fat-diet-induces-depression-like-behaviour-in-mice-associated-with-changes-in-microbiome-neuropeptide-y-and-brain-metabolome
#8
Ahmed M Hassan, Giulia Mancano, Karl Kashofer, Esther E Fröhlich, Andrija Matak, Raphaela Mayerhofer, Florian Reichmann, Marta Olivares, Audrey M Neyrinck, Nathalie M Delzenne, Sandrine P Claus, Peter Holzer
OBJECTIVES: The biological mechanisms linking diet-related obesity and depression remain unclear. Therefore, we examined the impact of high-fat diet (HFD) on murine behaviour, intestinal microbiome, brain metabolome, neuropeptide Y (NPY) expression, and dipeptidyl peptidase-4 (DPP-4) activity. METHODS: Male C57Bl/6J mice were fed an HFD (60 kJ% from fat) or control diet (12 kJ% from fat) for 8 weeks, followed by behavioural phenotyping. Caecal microbiome was analysed by 16S rDNA sequencing, brain metabolome by 1 H nuclear magnetic resonance, NPY expression by PCR and immunoassay, and dipeptidyl peptidase-4 (DPP-4) activity by enzymatic assay...
April 26, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29692250/critical-role-of-dipeptidyl-peptidase-iv-a-therapeutic-target-for-cancer-diabetes
#9
Priyankar Paira, S K Ashok Kumar, Sourav De, Subhasis Banerjee
Dipeptidyl Peptidase is one of the novel targets for antidiabetic and anticancer drugs. The dipeptidyl amminopeptidase IV, expressed in mammalian, releases X-Pro/Ala dipeptides from the N-terminus of peptides. It is responsible for the degradation of the incretin hormones which regulate blood glucose level. At present several DPP-IV inhibitors are approved for type-2 diabetes mellitus. These enzymes are also expressed in dimeric form on the surface of different cells (mature thymocytes, activated T cells, B cells, NK cells, macrophages, renal, prostate, liver and small intestinal epithelium, biliary canaliculae, and splenic sinus lining cells)...
April 22, 2018: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/29688809/usp7-trim27-axis-negatively-modulates-antiviral-type-i-ifn-signaling
#10
Juan Cai, Hong-Yan Chen, Shu-Jie Peng, Jun-Ling Meng, Yan Wang, Yu Zhou, Xiao-Ping Qian, Xiu-Yuan Sun, Xue-Wen Pang, Yu Zhang, Jun Zhang
Ubiquitination and deubiquitination are important post-translational regulatory mechanisms responsible for fine tuning the antiviral signaling. In this study, we identified a deubiquitinase, the ubiquitin-specific peptidase 7/herpes virus associated ubiquitin-specific protease (USP7/HAUSP) as an important negative modulator of virus-induced signaling. Overexpression of USP7 suppressed Sendai virus and polyinosinic-polycytidylic acid and poly(deoxyadenylic-deoxythymidylic)-induced ISRE and IFN-β activation, and enhanced virus replication...
April 24, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29682682/molecular-and-clinical-roles-of-incretin-based-drugs-in-patients-with-heart-failure
#11
REVIEW
Bassant Orabi, Rasha Kaddoura, Amr S Omar, Cornelia Carr, Abdulaziz Alkhulaifi
Glucagon-like peptide-1 (GLP-1) agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors produce some beneficial and deleterious effects in diabetic patients not mediated by their glycemic lowering effects, and there is a need for better understanding of the molecular basis of these effects. They possess antioxidant and anti-inflammatory effects with some direct vasodilatory action (animal and human trial data) that may indirectly influence heart failure (HF). Unlike GLP-1R agonists, signaling for HF adverse effects was observed with two DPP-4 inhibitors, saxagliptin and alogliptin...
April 23, 2018: Heart Failure Reviews
https://www.readbyqxmd.com/read/29670704/optimization-of-a-%C3%AE-lactam-scaffold-for-antibacterial-activity-via-the-inhibition-of-bacterial-type-i-signal-peptidase
#12
Chien-Hung Yeh, Shawn I Walsh, Arryn Craney, M Greg Tabor, Ana-Florina Voica, Ramkrishna Adhikary, Sydney E Morris, Floyd E Romesberg
β-Lactam antibiotics, one of the most important class of human therapeutics, act via the inhibition of penicillin-binding proteins (PBPs). The unparalleled success in their development has inspired efforts to develop them as inhibitors of other targets. Bacterial type I signal peptidase is evolutionarily related to the PBPs, but the stereochemistry of its substrates and its catalytic mechanism suggest that β-lactams with the 5 S stereochemistry, as opposed to the 5 R stereochemistry of the traditional β-lactams, would be required for inhibition...
April 12, 2018: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29618843/rudhira-bcas3-is-essential-for-mouse-development-and-cardiovascular-patterning
#13
Ronak Shetty, Divyesh Joshi, Mamta Jain, Madavan Vasudevan, Jasper Chrysolite Paul, Ganesh Bhat, Poulomi Banerjee, Takaya Abe, Hiroshi Kiyonari, K VijayRaghavan, Maneesha S Inamdar
Rudhira/Breast Carcinoma Amplified Sequence 3 (BCAS3) is a cytoskeletal protein that promotes directional cell migration and angiogenesis in vitro and is implicated in human carcinomas and coronary artery disease. To study the role of Rudhira during development in vivo, we generated the first knockout mouse for rudhira and show that Rudhira is essential for mouse development. Rudhira null embryos die at embryonic day (E) 9.5 accompanied by severe vascular patterning defects in embryonic and extra-embryonic tissues...
April 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29604377/pomegranate-polyphenols-and-urolithin-a-inhibit-%C3%AE-glucosidase-dipeptidyl-peptidase-4-lipase-triglyceride-accumulation-and-adipogenesis-related-genes-in-3t3-l1-adipocyte-like-cells
#14
Francisco Les, José Miguel Arbonés-Mainar, Marta Sofía Valero, Víctor López
ETHNOPHARMACOLOGICAL RELEVANCE: pomegranate fruit is considered an antidiabetic medicine in certain systems of traditional medicine. In addition, pomegranate polyphenols are known as powerful antioxidants with beneficial effects such as the reduction of oxidative / inflammatory stress and the increase of protective signalling such as antioxidant enzymes, neurotrophic factors and cytoprotective proteins. AIM OF THE STUDY: this work evaluates the effects of pomegranate juice, its main polyphenols known as ellagic acid and punicalagin, as well as its main metabolite urolithin A, on physiological and pharmacological targets of metabolic diseases such as obesity and diabetes...
March 28, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29603541/augmentation-of-glucagon-like-peptide-1-receptor-signalling-by-neprilysin-inhibition-potential-implications-for-patients-with-heart-failure
#15
REVIEW
Milton Packer
Augmentation of glucagon-like peptide-1 (GLP-1) receptor signalling is an established approach to the treatment of type 2 diabetes. However, endogenous GLP-1 and long-acting GLP-1 receptor analogues are degraded not only by dipeptidyl peptidase-4, but also by neprilysin. This observation raises the possibilities that endogenous GLP-1 contributes to the clinical effects of neprilysin inhibition and that patients concurrently treated with sacubitril/valsartan and incretin-based drugs may experience important drug-drug interactions...
March 30, 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29593046/host-factor-spcs1-regulates-the-replication-of-japanese-encephalitis-virus-through-interactions-with-transmembrane-domains-of-ns2b
#16
Le Ma, Fang Li, Jing-Wei Zhang, Wei Li, Dong-Ming Zhao, Han Wang, Rong-Hong Hua, Zhi-Gao Bu
Signal peptidase complex subunit 1 (SPCS1) is a newly identified host factor that regulates flavivirus replication, but the molecular mechanism is not fully understood. Herein, using Japanese encephalitis virus (JEV) as a model, we investigated the mechanism through which host factor SPCS1 regulates the replication of flaviviruses. We first validated the regulatory function of SPCS1 in JEV propagation by knocking down and knocking out endogenous SPCS1. Loss of SPCS1 function markedly reduced intracellular virion assembly and production of infectious JEV particles, but did not affect virus cell entry, RNA replication, or translation...
March 28, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29568943/identification-of-aberrantly-expressed-long-non-coding-rnas-in-postmenopausal-osteoporosis
#17
Qi Fei, Xiaodong Bai, Jisheng Lin, Hai Meng, Yong Yang, Ai Guo
Postmenopausal osteoporosis (PMOP) is a common skeletal disorder in postmenopausal women. The present study aimed to identify the key long non‑coding RNAs (lncRNAs) in PMOP through RNA sequencing. RNA sequencing was performed to obtain the expression profile of lncRNAs and mRNAs in blood samples of patients with PMOP and normal controls (NCs). Following the identification of differentially expressed mRNAs (DEmRNAs) and differentially expressed lncRNAs (DElncRNAs), the DElncRNA-DEmRNA co‑expression network was constructed...
March 19, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29562778/evidence-of-amniotic-epithelial-cell-differentiation-toward-hepatic-sinusoidal-endothelial-cells
#18
Monica Serra, Michela Marongiu, Antonella Contini, Toshio Miki, Erika Cadoni, Ezio Laconi, Fabio Marongiu
Amniotic epithelial cells (AECs) represent a useful and noncontroversial source for liver-based regenerative medicine, as they can differentiate into hepatocytes upon transplantation into the liver. However, the possibility that AECs can differentiate into other liver cell types, such as hepatic sinusoidal endothelial cells (HSECs), has never been assessed. In order to test this hypothesis, rat- and human-derived AECs (rAECs and hAECs, respectively) were subjected to endothelial cell tube formation assay in vitro...
January 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29549541/role-of-the-angiotensin-converting-enzyme-in-the-g-csf-induced-mobilization-of-progenitor-cells
#19
Karin Kohlstedt, Caroline Trouvain, Timo Frömel, Thomas Mudersbach, Reinhard Henschler, Ingrid Fleming
In addition to being a peptidase, the angiotensin-converting enzyme (ACE) can be phosphorylated and involved in signal transduction. We evaluated the role of ACE in granulocyte-colony-stimulating factor (G-CSF)-induced hematopoietic progenitor cell (HPC) mobilization and detected a significant increase in mice-lacking ACE. Transplantation experiments revealed that the loss of ACE in the HPC microenvironment rather than in the HPCs increased mobilization. Indeed, although ACE was expressed by a small population of bone-marrow cells, it was more strongly expressed by endosteal bone...
March 17, 2018: Basic Research in Cardiology
https://www.readbyqxmd.com/read/29545777/the-bacteroidetes-q-rule-pyroglutamate-in-signal-peptidase-i-substrates
#20
Matthias Bochtler, Danuta Mizgalska, Florian Veillard, Magdalena L Nowak, John Houston, Paul Veith, Eric C Reynolds, Jan Potempa
Bacteroidetes feature prominently in the human microbiome, as major colonizers of the gut and clinically relevant pathogens elsewhere. Here, we reveal a new Bacteroidetes specific feature in the otherwise widely conserved Sec/SPI (Sec translocase/signal peptidase I) pathway. In Bacteroidetes , but not the entire FCB group or related phyla, signal peptide cleavage exposes N-terminal glutamine residues in most SPI substrates. Reanalysis of published mass spectrometry data for five Bacteroidetes species shows that the newly exposed glutamines are cyclized to pyroglutamate (also termed 5-oxoproline) residues...
2018: Frontiers in Microbiology
keyword
keyword
115016
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"