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https://www.readbyqxmd.com/read/28723772/anatomic-investigation-of-lumbar-transforaminal-fenestration-approach-and-its-clinical-application-in-far-lateral-disc-herniation
#1
Baoshan Xu, Haiwei Xu, Jean Destandau, Xinlong Ma, Jian He, Qun Xia, Ning Ji, Qiang Yang, Yue Liu, Hongfeng Jiang
Treating lumbar disease at the intervertebal foramina is controversial because we lack an approach providing sufficient exposure and preserving spinal stability. The primary objective of this study was to investigate the feasibility of the transforaminal fenestration (TFF) approach for treating lumbar disease involving the intervertebal foramina.In the anatomic study of 30 adult cadaveric lumbar spine specimens, the TFF approach was used from L1 to S1. The scope of resection was measured manually and on 3D CT images...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28723306/inclusion-of-lesbian-gay-bisexual-transgender-queer-and-intersex-health-in-australian-and-new-zealand-medical-education
#2
Asiel Adan Sanchez, Erica Southgate, Gary Rogers, Robbert J Duvivier
PURPOSE: This study aims at establishing the scope of lesbian, gay, bisexual, transgender, queer, and intersex (LGBTQI) health in Australian and New Zealand medical curricula. METHODS: We sent medical school curriculum administrators an online cross-sectional survey. RESULTS: The response rate was 15 medical schools (71%): 14 Australian schools and 1 New Zealand school. Respondents included program directors (n = 5; 33%), course coordinators (n = 4; 27%), Heads of School (n = 2; 13%), one Dean (7%), and three others (20%)...
July 19, 2017: LGBT Health
https://www.readbyqxmd.com/read/28723104/chemo-and-stereoselective-crotylation-of-aldehydes-and-cyclic-aldimines-with-allylic-gem-diboronate-ester
#3
Jinyoung Park, Seoyoung Choi, Yeosan Lee, Seung Hwan Cho
We report a highly chemo- and stereoselective crotylation of aldehydes and cyclic aldimines with allylic-gem-diboronate ester as a new type of organoboron reagent. The allylic-gem-diboronate ester undergoes the crotylation with aldehydes and cyclic aldimines in excellent stereoselectivity, forming anti-5,6-disubstituted oxaborinin-2-ols or (E)-δ-boryl-anti-homoallylic amines in high efficiency. The reaction shows a wide range of substrate scope and excellent functional group tolerance. The synthetic applications of the obtained products, including stereospecific C-C, C-O, and C-Cl bond formation, are also demonstrated...
July 19, 2017: Organic Letters
https://www.readbyqxmd.com/read/28722796/extended-catalytic-scope-of-a-well-known-enzyme-asymmetric-reduction-of-iminium-substrates-by-glucose-dehydrogenase
#4
Sebastian Roth, Andreas Präg, Cindy Wechsler, Marija Marolt, Sascha Ferlaino, Steffen Lüdeke, Nicolas Sandon, Dennis Wetzl, Hans Iding, Beat Wirz, Michael Müller
NADP(H)-dependent imine reductases (IREDs) are of interest in biocatalytic research due to their ability to generate chiral amines from imine/iminium substrates. In reaction protocols involving IREDs, glucose dehydrogenase (GDH) is generally used to regenerate the expensive cofactor NADPH by oxidation of d-glucose to gluconolactone. We have characterized different IREDs with regard to reduction of a set of bicyclic iminium compounds and have utilized (1) H NMR and GC analyses to determine degree of substrate conversion and product enantiomeric excess (ee)...
July 19, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28722774/-promoting-continuity-of-care-specialist-nurses-role-experiences-in-gynaecological-oncology-a-qualitative-study
#5
Andrea Kobleder, Hanna Mayer, Larissa Gehrig, Beate Senn
AIMS AND OBJECTIVES: To investigate the experiences of specialist nurses in Switzerland concerning their role of caring for women with gynaecological cancer. BACKGROUND: Women with gynaecological cancer often face complex situations, which require an integrative and quality-assured approach by the healthcare system. Specialist nurses can play an important role in supporting these patients. However, in countries where the role of specialist nurses is at a developmental stage, their role lacks clarity...
July 19, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28722555/understanding-the-state-of-health-policy-and-systems-research-in-west-africa-and-capacity-strengthening-needs-scoping-of-peer-reviewed-publications-trends-and-patterns-1990-2015
#6
Selina Defor, Aku Kwamie, Irene Akua Agyepong
BACKGROUND: The need for locally-driven, locally-generated evidence to guide health policy and systems decision-making and implementation in West Africa remains urgent. Thus, health policy and systems research (HPSR) is a field with great potential for addressing many of the sub-region's intransigent health challenges. This paper presents an analysis of trends and patterns of peer-reviewed HPSR publications across the Economic Community of West African States (ECOWAS), to help understand trends and patterns of HPSR publication and the degree of involvement of West African researchers in HPSR evidence generation in the sub-region...
July 12, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/28722305/dynamic-covalent-chemistry-of-aldehyde-enamines-bi-iii-and-sc-iii-catalysis-of-amine-enamine-exchange
#7
Yang Zhang, Sheng Xie, Mingdi Yan, Olof Ramström
The dynamic exchange of enamines from secondary amines and enolizable aldehydes has been demonstrated in organic solvents. The enamine exchange with amines was efficiently catalyzed by Bi(OTf)3 and Sc(OTf)3 (2 mol%) and the equilibria (60 mM) could be attained within hours at room temperature. The formed dynamic covalent systems displayed high stabilities in basic environment with < 2% by-product formation within one week after complete equilibration. This study expands the scope of dynamic C-N bonds from imine chemistry to enamines, enabling further dynamic methodologies in exploration of this important class of structures in systems chemistry...
July 18, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28721955/spatiotemporal-clustering-of-dengue-cases-in-thiruvananthapuram-district-kerala
#8
Joanna Sara Valson, Biju Soman
BACKGROUND: Dengue cases are increasing in Kerala since 2010. Information on clustering of cases across locations and time periods is vital for disease surveillance and timely control. OBJECTIVES: The objective is to study spatiotemporal clustering of dengue cases and their climatic and physioenvironmental correlates in Thiruvananthapuram district during 2010-2014. METHODS: Health department data on reported cases of dengue were obtained from January 2011 to June 2014...
April 2017: Indian Journal of Public Health
https://www.readbyqxmd.com/read/28721593/public-policies-and-interventions-for-diabetes-in-latin-america-a-scoping-review
#9
REVIEW
Elizabeth Kaselitz, Gurpreet K Rana, Michele Heisler
PURPOSE OF REVIEW: Successful interventions are needed to diagnose and manage type 2 diabetes (T2DM) in Latin America, a region that is experiencing a significant rise in rates of T2DM. Complementing an earlier review exploring diabetes prevention efforts in Latin America, this scoping review examines the literature on (1) policies and governmental programs intended to improve diabetes diagnosis and treatment in Latin America and (2) interventions to improve diabetes management in Latin America...
August 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28721476/post-prandial-physiology-and-intestinal-morphology-of-the-pacific-hagfish-eptatretus-stoutii
#10
Alyssa M Weinrauch, Alexander M Clifford, Greg G Goss
Hagfishes are unique to the vertebrate lineage in that they acquire dissolved nutrients across multiple epithelia including the intestine, gill, and skin. This feat has been attributed to their immersive feeding behavior that likely simultaneously provides benefits (nutrient rich) and potentially adverse (hypercapnia, hypoxia, high environmental ammonia) physiological effects. Examinations have been conducted of the ex vivo transport capabilities of specific nutrients as well as in vivo effects of the hypothesized feeding environments, yet the physiological effects of feeding itself have never been elucidated...
July 18, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/28721169/investigating-an-outbreak-of-measles-in-margibi-county-liberia-october-2015
#11
Joseph Asamoah Frimpong, Maame Pokuah Amo-Addae, Peter Adebayo Adewuyi, Meeyoung Mattie Park, Casey Daniel Hall, Thomas Knue Nagbe
The emergence and re-emergence of infectious diseases highlights the need to have well-trained field epidemiologists who will be at the forefront in the fight against these diseases, especially during an outbreak. Training for outbreak investigation is most effective when participants can develop their competencies in a practical exercise. To that end, this case study was based on a measles outbreak investigation conducted in Liberia during October 2015 by Liberia Frontline Field Epidemiology Training Program (FETP) residents, simulating steps to perform outbreak investigation in a real-life situation as a field epidemiologist...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28720780/parameter-determination-and-transformation-for-the-focusing-of-dielectric-microspheres-illuminated-by-optical-needle
#12
Tongnan Xia, Hanming Guo, Jinbing Hu, Songlin Zhuang
By eliminating the spherical aberrations of microsphere we derived a simple but useful formula on the focusing of dielectric microsphere. On basis of this formula, not only can researchers determine the parameters of an optical microsphere system with super-resolution, but they can also perform parameter transformation. In order to facilitate the application, the principle of parameter transformation was summarized into three kinds of case listed in Table 1, which were all demonstrated numerically with concrete examples by finite-difference time-domain method...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28720624/screening-for-social-determinants-of-health-in-michigan-health-centers
#13
Elena Byhoff, Alicia J Cohen, Mary C Hamati, Julie Tatko, Matthew M Davis, Renuka Tipirneni
OBJECTIVE: Through an academic-community partnership with a statewide consortium of health centers (HCs) in Michigan, we characterize the current scope of screening for social determinants of health (SDH). METHODS: We requested copies of forms used to screen for SDH at the 39 HC organizations in Michigan. Using content analysis, we examined variation in screening domains and processes. We present descriptive analyses of HC characteristics and patient demographics...
July 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28720622/intention-versus-reality-family-medicine-residency-graduates-intention-to-practice-obstetrics
#14
Tyler W Barreto, Aimee R Eden, Stephen Petterson, Andrew W Bazemore, Lars E Peterson
Although 21% of new family medicine graduates in 2016 reported an intention to include obstetric delivery in their scope of practice, only 7% of family physicians currently do so. The reasons for this stark difference must be identified in order to address potential barriers leading to family medicine graduates ultimately not including obstetric delivery despite intent.
July 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28720515/ahrq-series-on-complex-intervention-systematic-reviews-paper-4-selecting-analytic-approaches
#15
Meera Viswanathan, Melissa L McPheeters, M Hassan Murad, Mary E Butler, Emily E Beth Devine, Michele P Dyson, Jeanne-Marie Guise, Leila C Kahwati, Jeremy N V Miles, Sally C Morton
BACKGROUND: Systematic reviews of complex interventions can vary widely in purpose, data availability and heterogeneity, and stakeholder expectations. RATIONALE: This article addresses the uncertainty that systematic reviewers face in selecting methods for reviews of complex interventions. Specifically, it lays out parameters for systematic reviewers to consider when selecting analytic approaches that best answer the questions at hand, and suggests analytic techniques that may be appropriate in different circumstances...
June 29, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28720514/ahrq-series-on-complex-intervention-systematic-reviews-paper-2-defining-complexity-formulating-scope-and-questions
#16
Michael P Kelly, Jane Noyes, Robert L Kane, Christine Chang, Stacey Uhl, Karen A Robinson, Stacey Springs, Mary E Butler, Jeanne-Marie Guise
BACKGROUND: The early stages of a systematic review set the scope and expectations. This can be particularly challenging for complex interventions given their multi-dimensional and dynamic nature. RATIONALE: This paper builds on concepts introduced in Paper 1 of this series. It describes the methodological, practical and philosophical challenges and potential approaches for formulating the questions and scope of systematic reviews of complex interventions. Further it discusses the use of theory to help organize reviews of complex interventions...
June 29, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28720510/ahrq-series-on-complex-intervention-systematic-reviews-paper-3-adapting-frameworks-to-develop-protocols
#17
Mary Butler, Richard A Epstein, Annette Totten, Evelyn P Whitlock, Mohammed T Ansari, Laura J Damschroder, Ethan Balk, Eric B Bass, Nancy D Berkman, Susanne Hempel, Suchitra Iyer, Karen Schoelles, Jeanne-Marie Guise
BACKGROUND: Once a proposed topic has been identified for a systematic review and has undergone a question formulation stage, a protocol must be developed that specifies the scope and research questions in detail and outlines the methodology for conducting the systematic review. RATIONALE: Framework modifications are often needed to accommodate increased complexity. We describe and give examples of adaptations as well as alternatives to traditional analytic frameworks...
June 27, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28720474/nitrous-oxide-cryotherapy-for-treatment-of-esophageal-squamous-cell-neoplasia-initial-multicenter-international-experience-with-a-novel-portable-cryoballoon-ablation-system-with-video
#18
Marcia Irene Canto, Julian Abrams, Hannah Kunzli, Bas Weusten, Yoshihiro Komatsu, Blair Jobe, Charles J Lightdale
BACKGROUND AND AIMS: Early esophageal squamous cell neoplasia (ESCN) can be successfully treated by endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD), or radiofrequency ablation (RFA). A new portable, battery-powered cryotherapy system using nitrous oxide (cryoballoon focal ablation system (CbFAS) has been used for Barrett's esophagus. It consists of a small hand-held device containing liquid nitrous oxide, which converts to gas within a low-pressure-compliant through-the-scope balloon and freezes targeted mucosa in contact with the balloon...
July 15, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28720368/a-critical-review-of-miniaturised-percutaneous-nephrolithotomy-is-smaller-better
#19
REVIEW
Silvia Proietti, Guido Giusti, Mahesh Desai, Arvind P Ganpule
CONTEXT: In an effort to reduce morbidity related to percutaneous nephrolithotomy (PCNL), some investigators have progressively introduced miniaturised approaches. The development of miniaturised nephroscopes facilitated widespread dissemination of these techniques and a significant expansion of the role of PCNL in endourology. OBJECTIVE: To discuss the different techniques comprising modern PCNL and identify the pros and cons of each of them. EVIDENCE ACQUISITION: Data for this review were identified through a search of PubMed, including studies published in the last 20 yr in core clinical journals in English...
February 2017: European Urology Focus
https://www.readbyqxmd.com/read/28720366/the-evolving-role-of-retrograde-intrarenal-surgery-in-the-treatment-of-urolithiasis
#20
REVIEW
Francesco Sanguedolce, Giorgio Bozzini, Ben Chew, Panagiotis Kallidonis, Jean de la Rosette
CONTEXT: Retrograde intrarenal surgery has gained substantial popularity worldwide thanks to continuous improvements in technology and techniques, and is now considered one of the first-line treatment options for active removal of renal stones. OBJECTIVE: To provide a comprehensive synthesis of the main evidences in literature on the current management of kidney stones by means of retrograde intrarenal surgery (RIRS). EVIDENCE ACQUISITION: A review of literature has been conducted using search string "retrograde intrarenal surgery OR flexible ureteroscop* OR ureterorenoscop*", without any language restriction; PubMed, Embase, and Scopus databases were searched in November 2016...
February 2017: European Urology Focus
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