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https://www.readbyqxmd.com/read/28930796/navigating-t-cell-immunometabolism-in-transplantation
#1
Naoki Tanimine, Laurence A Turka, Bhavana Priyadharshini
Recently, a new discipline termed "immunometabolism" has transformed the field of immunology. It encompasses the study of the intrinsic metabolic pathways of different immune subsets and their impact on cellular fate and function. For instance, broadly speaking, pro-inflammatory cells depend upon glycolysis and glutamine oxidation while cells involved in anti-inflammatory response such as Foxp3+ regulatory T cells (Tregs) utilize predominantly fatty acid oxidation. However, while a useful paradigm, this actually is a reductionist view and the engagement of these metabolic pathways is not mutually exclusive between these subsets...
September 19, 2017: Transplantation
https://www.readbyqxmd.com/read/28930705/how-we-become-who-we-are-ashley-carla-and-the-rest-of-us
#2
Jamie Lindemann Nelson
Lisa Freitag and Joan Liaschenko's thoughtful and important article goes directly to the under-examined heart of Ashley's case, namely to what sustains her in a habitable and intelligible identity. Though quite sympathetic with their conclusion and line of argument, I try to trouble their proceedings a bit, largely by wondering how having a specific such identity, out of several that may be in-principle available, matters to someone with Ashley's cognitive scope. I do this not simply to be contrary, but because their article also seems to me to raise issues in the ethics of bioethics-in particular, what I call the dilemma of ethical endeavor: How ought one publicly pursue deeply important and complex issues, the very raising of which may offend interlocutors who indeed have grounds for resentment...
2017: Journal of Clinical Ethics
https://www.readbyqxmd.com/read/28930594/lipid-metabolism-and-transport-define-longevity-of-the-yeast-saccharomyces-cerevisiae
#3
Darya Mitrofanova, Pamela Dakik, Melissa McAuley, Younes Medkour, Karamat Mohammad, Vladimir I Titorenko
Emergent evidence indicates that certain aspects of lipid synthesis, degradation and interorganellar transport play essential roles in modulating the pace of cellular aging in the budding yeast Saccharomyces cerevisiae. The molecular mechanisms underlying the vital roles of lipid metabolism and transport in defining yeast longevity have begun to emerge. The scope of this review is to critically analyze recent progress in understanding such mechanisms.
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930455/regioselective-iridium-catalyzed-asymmetric-monohydrogenation-of-1-4-dienes
#4
Jianguo Liu, Suppachai Krajangsri, Thishana Singh, Giulia De Seriis, Napasawan Chumnanvej, Haibo Wu, Pher G Andersson
A highly efficient regio- and enantioselective monohydrogenation of 1,4-dienes has been realized using an iridium catalyst with a chiral N,P-ligand under mild conditions. The substrate scope was studied and included both unfunctionalized as well as functionalized substituents on the meta- or para-position. Substrates having substituents with functionalities such as silyl protected alcohols or ketals were monohydrogenated in high regioselectivity and high enantiomeric excess (up to 98% ee).
September 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28930446/probing-coordination-complexes-by-carbon-nanotube-assisted-low-voltage-paper-spray-ionization-mass-spectrometry
#5
Rahul Narayanan, Thalappil Pradeep
Fragile transition metal complex ions such as [Cr(H2O)4Cl2]+, difficult to be observed by gas phase spectroscopy, are detected easily with carbon nanotube (CNT) assisted low voltage ambient ionization mass spectrometry. Observation of various substituted ions with D2O and ROH (R = CH3, C2H5…) established the versatility of the technique in detecting diverse species. Ligand substitution occurring in solution was captured by the low voltage technique. Extreme softness of the technique coupled with nanoscale ion sources enabled the creation of such species...
September 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28930177/molecules-new-aims-and-scope
#6
EDITORIAL
Derek J McPhee
As we approach the end of our 22nd year as the pioneering and preeminent Open Access journal in the field of organic chemistry and natural products, time has come to formally announce what has been the de facto reality of the journal for the past few years, the expansion of the range of topics we cover.[...].
September 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28929961/-national-antimicrobial-resistance-surveillance-system-namrss-external-quality-assessment-studies-2011-2016
#7
Serap Süzük Yıldız, Hüsniye Şimşek, Nilay Çöplü, Zeynep Gülay
Establishment of sustainable and evidence-based surveillance systems are recommended for prevention of microbial resistance by the World Health Organization (WHO). As a necessity of these surveillance systems, participants are recommended to implement an external quality assessment (EQA) program. In this scope, National Antimicrobial Resistance Surveillance System (NARSS) has been established within the Public Health Institute of Turkey (PHIT) in our country since 2011. In the scope of this surveillance, NARSS EQA program has been implemented in a cycle per year and four isolates were sent to participants per cycle every year since 2011...
July 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28929863/the-effects-of-clinical-supervision-on-supervisees-and-patients-in-cognitive-behavioral-therapy-a-systematic-review
#8
Sven Alfonsson, Thomas Parling, Åsa Spännargård, Gerhard Andersson, Tobias Lundgren
BACKGROUND: Clinical supervision is a central part of psychotherapist training but the empirical support for specific supervision theories or features is unclear. The aims of this study were to systematically review the empirical research literature regarding the effects of clinical supervision on therapists' competences and clinical outcomes within Cognitive Behavior Therapy (CBT). METHOD: A comprehensive database search resulted in 4103 identified publications...
September 20, 2017: Cognitive Behaviour Therapy
https://www.readbyqxmd.com/read/28929763/synthesis-of-spiro-pyrazolin-3-3-oxindoles-and-3-arylcarbonylmethyl-substituted-ylideneoxindoles-by-1-3-dipolar-cycloadditions-of-3-ylideneoxindoles-and-in-situ-generated-%C3%AE-diazoketones
#9
Shan Jiang, Hong-Mei Guo, Sheng Yao, De-Qing Shi, Wen-Jing Xiao
An efficient 1,3-dipolar cycloaddition of 3-ylideneoxindoles with in situ-generated α-diazoketones to potentially biological active spiro[pyrazolin-3,3'-oxindoles] 4 with excellent regioselectivity and diastereoselectivity and synthetically useful building block 3-arylcarbonylmethyl substituted ylideneoxindoles 5 in different conditions has been developed. This method has advantages of mild conditions, simple work-up, wide substrate scopes as well as without using any transition metal catalyst.
September 20, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28929038/drainage-after-modified-radical-mastectomy-a-methodological-mini-review
#10
REVIEW
George S Stoyanov, Dragostina Tsocheva, Katerina Marinova, Emil Dobrev, Rumen Nenkov
Breast cancer is a socially relevant group of malignant conditions of the mammary gland, affecting both males and females. Most commonly the surgical approach of choice is a modified radical mastectomy (MRM), due to it allowing for both the removal of the main tumor mass and adjacent glandular tissue, which are suspected of infiltration and multifocality of the process, and a sentinel axillary lymph node removal. Most common post-surgical complications following MRM are the formation of a hematoma, the infection of the surgical wound and the formation of a seroma...
July 10, 2017: Curēus
https://www.readbyqxmd.com/read/28928974/the-influence-of-water-temperature-on-sockeye-salmon-heart-rate-recovery-following-simulated-fisheries-interactions
#11
Tanya S Prystay, Erika J Eliason, Michael J Lawrence, Melissa Dick, Jacob W Brownscombe, David A Patterson, Glenn T Crossin, Scott G Hinch, Steven J Cooke
Selective harvest policies have been implemented in North America to enhance the conservation of Pacific salmon (Oncorhynchus spp.) stocks, which has led to an increase in the capture and release of fish by all fishing sectors. Despite the immediate survival benefits, catch-and-release results in capture stress, particularly at high water temperatures, and this can result in delayed post-release mortality minutes to days later. The objective of this study was to evaluate how different water temperatures influenced heart rate disturbance and recovery of wild sockeye salmon (Oncorhynchus nerka) following fisheries interactions (i...
2017: Conservation Physiology
https://www.readbyqxmd.com/read/28928355/role-of-endoscopy-in-the-management-of-boerhaave-syndrome
#12
Juan Ignacio Tellechea, Jean-Michel Gonzalez, Pablo Miranda-García, Adrian Culetto, Xavier Benoit D'Journo, Pascal Alexandre Thomas, Marc Barthet
Boerhaave syndrome (BS) is a spontaneous esophageal perforation which carries high mortality. Surgical treatment is well established, but the development of interventional endoscopy has proposed new therapies. We expose our experience in a Gastrointestinal and Endoscopy Unit. With a retrospective, observational, open-label, single center, consecutive case series. All patients diagnosed with BS who were managed in our center were included. Treated conservatively, endoscopically or surgically, according to their clinical condition and lesion presentation...
September 20, 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/28928297/malnutrition-free-india-dream-or-reality
#13
C P Mishra
In spite of great efforts done by the Government of India to tackle the problem of malnutrition, proportion of population normal on nutrition scale has been stationary; nearly half of them have been a victim of under- and over-nutrition. Over a period, undernutrition has declined but this has been compensated by overnutrition. Hidden hunger is a still an unfinished agendum. The achievement of food grain security at the national level did not percolate down, and households' food insecurity and level of chronic food insecurity are still high...
July 2017: Indian Journal of Public Health
https://www.readbyqxmd.com/read/28928262/the-use-of-speaking-valves-in-children-with-tracheostomy-tubes-what-is-the-scope-of-the-literature
#14
Weeda Zabih, Theresa Holler, Faiza Syed, Laurie Russell, Jennifer Allegro, Reshma Amin
One-way speaking valves have been successfully used to restore audible meaningful speech in adult patients after tracheostomy tube placement. One-way speaking valves have also been used in pediatric patients after tracheostomy tube placement with promising results. We conducted a scoping review to synthesize and summarize the current evidence on the use of one-way tracheostomy tube speaking valves in the pediatric population to identify knowledge gaps that could inform future research programs and facilitate evidence-based clinical decision making...
September 19, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28928196/protocol-for-a-scoping-review-of-skin-self-care-of-people-with-spinal-cord-injury
#15
Daniella Karine Souza Lima, Soraia Dornelles Schoeller, Neide da Silva Knihs, Caroline Porcelis Vargas, Adriana Dutra Tholl, Soraia Geraldo Rozza Lopes, Maria Manuela Martins, Karina Silveira de Almeida Hammerschmidt
INTRODUCTION: In recent years, increasing methodological references have been used in scientific research; these are points of support in the search for evidence, formulation and elaboration of instruments, scales, guideline and protocols. However, significant variability currently exists in scoping review conduct and reporting, thus limiting the potential of the methodology to advance research and practice about skin self-care of people with spinal cord injury (SCI). Our objective was to perform a scoping review protocol within the health rehabilitation context of people with SCI, focusing on skin self-care...
September 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28927926/short-dental-implants-a-scoping-review-of-the-literature-for-patients-with-head-and-neck-cancer
#16
REVIEW
Faraj Edher, Caroline T Nguyen
STATEMENT OF PROBLEM: Dental implants can be essential in the rehabilitation of various cancer defects, but their ideal placement can be complicated by the limited dimensions of the available host bone. Surgical interventions developed to increase the amount of bone are not all predictable or successful and can sometimes be contraindicated. Short dental implants have been suggested as an alternative option in sites where longer implants are not possible. Whether they provide a successful treatment option is unclear...
September 16, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28927624/investigation-of-lanthanum-impregnated-cellulose-derived-from-biomass-as-an-adsorbent-for-the-removal-of-fluoride-from-drinking-water
#17
Ammavasi Nagaraj, Kishor Kumar Sadasivuni, Mariappan Rajan
High concentrations of fluoride in drinking water can cause the disease fluorosis. Our scope goal is to develop an effective biopolymeric adsorbent for the removal of fluoride to below a specific safety limit set by the World Health Organization. In this study, the natural adsorbent material cellulose was impregnated with lanthanum chloride and effectiveness in adsorbing fluoride was confirmed by FT-IR, XRD, and SEM coupled with EDX techniques. The adsorption data were analyzed by Freundlich, Langmuir, and Redlich-Peterson isotherms...
November 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28927493/review-of-patient-reported-experience-within-patient-centered-medical-homes-insights-for-australian-health-care-homes
#18
Mary O'Loughlin, Jane Mills, Robyn McDermott, Linton Harriss
Understanding patient experience is necessary to advance the patient-centred approach to health service delivery. Australia's primary healthcare model, the 'Health Care Home', is based on the 'Patient-Centered Medical Home' (PCMH) model developed in the United States. Both these models aim to improve patient experience; however, the majority of existing PCMH model evaluations have focussed on funding, management and quality assurance measures. This review investigated the scope of evidence reported by adult patients using a PCMH...
September 20, 2017: Australian Journal of Primary Health
https://www.readbyqxmd.com/read/28927355/the-promise-of-qualitative-research-to-inform-theory-to-address-health-equity
#19
Rachel C Shelton, Derek M Griffith, Michelle C Kegler
Most public health researchers and practitioners agree that we need to accelerate our efforts to eliminate health disparities and promote health equity. The past two decades of research have provided a wealth of descriptive studies, both qualitative and quantitative, that describe the size, scale, and scope of health disparities, as well as the key determinants that affect disparities. We need, however, to shift more aggressively to action informed by this research and develop deeper understandings of how to shape multilevel interventions, influenced by theories across multiple levels of the social-ecologic framework...
October 2017: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/28927239/tubulins-rhythms-and-cell-walls-in-poplar-leaves-it-s-all-in-the-timing
#20
Scott A Harding, Hao Hu, Batbayar Nyamdari, Liang-Jiao Xue, Radnaa Naran, Chung-Jui Tsai
Plant cell walls exhibit architectural and compositional changes throughout their development and in response to external cues. While tubulins are involved in cell wall biogenesis, much remains unknown about the scope of their involvement during the orchestration of this resource-demanding process. A transgenic approach coupled with cell wall compositional analysis, RNA-seq and mining of publicly available diurnal gene expression data was used to assess the involvement of tubulins in poplar leaf cell wall biogenesis...
September 12, 2017: Tree Physiology
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