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https://www.readbyqxmd.com/read/29166448/meta-evaluation-of-a-participatory-process-in-the-strengthening-of-municipal-management
#1
Cristiane Andrea Locatelli de Almeida, Oswaldo Yoshimi Tanaka
OBJECTIVE: To evaluate, with a focus on participation, an evaluation process developed by municipal managers and administrators of a health region in the state of São Paulo, considering the need for theoretical reflection on participatory health practices in the Brazilian context. METHODS: Qualitative research that used the framework developed by Daigneault and Jacob (2009) to analyze the empirical material, encompassing three dimensions of participation: control of the evaluation process, diversity of participants, and extent of their involvement...
2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29166289/a-statistical-method-for-analysing-cospeciation-in-tritrophic-ecology-using-electrical-circuit-theory
#2
Colleen Nooney, Stuart Barber, Arief Gusnanto, Walter R Gilks
We introduce a new method to test efficiently for cospeciation in tritrophic systems. Our method utilises an analogy with electrical circuit theory to reduce higher order systems into bitrophic data sets that retain the information of the original system. We use a sophisticated permutation scheme that weights interactions between two trophic layers based on their connection to the third layer in the system. Our method has several advantages compared to the method of Mramba et al. [Mramba, L. K., S. Barber, K...
November 22, 2017: Statistical Applications in Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29165967/measurements-of-self-efficacy-in-patients-with-chronic-kidney-disease-a-literature-review
#3
Yu-Jie Guo, Qing Tang, Yu Gu
This article reviews the literature addressing assessment instruments about various aspects of self-efficacy in patients with chronic kidney disease (CKD). Each scale's structure, reliability, validity, and clinical application are described in detail. When selecting assessment tools to measure the self-efficacy level of patients with CKD, we should take the suitable subjects and application scope into account. With valid and reliable measurement tools, researchers and clinical nurses can assess and stimulate the self-efficacy of patients with CKD more effectively and carry out targeted nursing interventions so as to improve patients' self-efficacy level...
March 2017: Nephrology Nursing Journal: Journal of the American Nephrology Nurses' Association
https://www.readbyqxmd.com/read/29165771/recent-perspectives-of-ependymomas-childhood-brain-tumors
#4
Z-D Zeng, F-L Liu, S-X Li
Ependymomas are childhood brain tumors that occur throughout the central nervous system, but are most common in the hindbrain, also known as the posterior fossa (PF). Current standard therapy comprises maximal safe surgery, and there is no scope for further increase in survival. Despite the histological similarity, ependymomas from throughout the neuroaxis likely comprise multiple independent entities, each with a distinct molecular pathogenesis. The present review article would discuss both genetics and epigenetics of ependymomas...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29165621/treatment-of-tuberculosis-in-complex-emergencies-in-developing-countries-a-scoping-review
#5
Geraldine Munn-Mace, Divya Parmar
Almost 172 million people live in complex emergencies globally resulting from political and/or economic instability. The provision and continuity of health care in complex emergencies remain a significant challenge. Health agencies are often hesitant to implement tuberculosis programmes in particular because its treatment requires a longer commitment than most acute diseases. However, not treating tuberculosis promptly increases mortality and untreated tuberculosis further increases the incidence of tuberculosis...
November 20, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29165473/large-cu-chalcogenone-cubic-cages-with-non-interacting-counter-ions
#6
Srinivas Katam, Prabusankar Ganesan
Two mega size copper(i) cubic cages, [{Cu(Bptp)1.5}8(PF6(-))](PF6(-))7 (1) and [{Cu(Bpsp)1.5}8(PF6(-))](PF6(-))7 (2), supported by imidazole-2-chalcogenone ligands (Bptp = 2,6-bis(1-isopropylimidazole-2-thione)pyridine and Bpsp = 2,6-bis(1-isopropylimidazole-2-selone)pyridine) have been synthesized and characterized. The formation of ionic salts 1 and 2 was confirmed by FT-IR, multinuclear ((1)H, (13)C, (31)P and (19)F) NMR, UV-vis, TGA, CHN analysis, BET analysis, single crystal X-ray diffraction and powder X-ray diffraction techniques...
November 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29165470/microwave-assisted-synthesis-of-hydroxyl-containing-isoquinolines-by-metal-free-radical-cyclization-of-vinyl-isocyanides-with-alcohols
#7
Dengqi Xue, Hao Chen, Yulong Xu, Haihua Yu, Linqian Yu, Wei Li, Qiong Xie, Liming Shao
A convenient microwave-assisted protocol for the synthesis of hydroxyl-containing isoquinolines from a metal-free radical cyclization reaction of vinyl isonitriles with alcohols was developed with moderate-to-excellent yields. Vinyl isonitriles are coupled with alkyl radicals through direct catalytic functionalization of the α sp(3) C-H bond of alcohols. The methodology demonstrates a broad substrate scope, shows excellent functional group tolerance, is highly atom-economical and highly efficient, thus enabling the preparation of diverse potentially valuable hydroxyl-containing isoquinolines...
November 22, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29165005/models-of-care-in-tele-ophthalmology-a-scoping-review
#8
Liam J Caffery, Monica Taylor, Glen Gole, Anthony C Smith
The objective of this review was to identify and describe telehealth models of care for ophthalmic services. We conducted a scoping review of the literature to identify how ophthalmic care can be delivered by telehealth. We searched the PubMed database to identify relevant articles which were screened based on pre-defined inclusion criteria. For included articles, data were extracted, categorised and analysed. Synthesis of findings was performed narratively. The scoping review included 78 articles describing 62 discrete tele-ophthalmic models of care...
January 1, 2017: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/29164725/a-scoping-review-of-environmental-health-nursing-research
#9
Barbara J Polivka, Rosemary V Chaudry
OBJECTIVE: The purpose of this scoping review was to determine the extent and focus of published environmental health nursing research. DESIGN AND SAMPLE: The search was limited to peer reviewed, English-language environmental health nursing research with at least one nursing author, published between 1995 and 2015 in a nursing journal, and catalogued in CINAHL. RESULTS: Publication of the 548 identified articles occurred in 118 different nursing journals...
November 22, 2017: Public Health Nursing
https://www.readbyqxmd.com/read/29164708/isolation-of-cp-co-iii-alkenyl-intermediate-in-efficient-cobalt-catalyzed-c-h-bond-alkenylation-with-alkynes
#10
Malay Sen, Nimmakuri Rajesh, Balakumar Emayavaramban, J Richard Premkumar, Basker Sundararaju
A general efficient, broad substrate scope for C-H bond alkenylation of arene catalyzed by Cp*Co(III) was demonstrated with alkynes. A highly selective mono-alkenylation and sequential bis-C-H bond functionalization was displayed to exemplify the versatility of the cobalt catalyst. Isolation of cationic Cp*Co(III)-alkenyl intermediate was achieved under identical catalytic conditions to further establish the proposed pathway.
November 22, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29164221/selective-c-h-bond-electro-oxidation-of-benzylic-acetates-and-alcohols-to-benzaldehydes
#11
Mateus R Barone, Alan M Jones
A chemical oxidant-free and mediator-free, direct electro-oxidation of both benzylic alcohols and benzylic esters are reported. The scope of the reaction is explored as a function of both steric and electronic effects. Expansion of the scope to non-benzylic and heteroaryl substrates is investigated. Functionalisation of esters and alcohols selectively to the aldehyde oxidation level using a traceless electron approach is reported.
November 22, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29164036/a-clinical-practice-guideline-for-the-management-of-acute-spinal-cord-injury-introduction-rationale-and-scope
#12
Michael G Fehlings, Lindsay A Tetreault, Jefferson R Wilson, Brian K Kwon, Anthony S Burns, Allan R Martin, Gregory Hawryluk, James S Harrop
Acute spinal cord injury (SCI) is a traumatic event that results in disturbances to normal sensory, motor, or autonomic function and ultimately affects a patient's physical, psychological, and social well-being. The management of patients with SCI has drastically evolved over the past century as a result of increasing knowledge on injury mechanisms, disease pathophysiology, and the role of surgery. There still, however, remain controversial areas surrounding available management strategies for the treatment of SCI, including the use of corticosteroids such as methylprednisolone sodium succinate, the optimal timing of surgical intervention, the type and timing of anticoagulation prophylaxis, the role of magnetic resonance imaging, and the type and timing of rehabilitation...
September 2017: Global Spine Journal
https://www.readbyqxmd.com/read/29164027/a-clinical-practice-guideline-for-the-management-of-degenerative-cervical-myelopathy-introduction-rationale-and-scope
#13
Michael G Fehlings, Lindsay A Tetreault, K Daniel Riew, James W Middleton, Jeffrey C Wang
Degenerative cervical myelopathy (DCM) is a progressive spine disease and the most common cause of spinal cord dysfunction in adults worldwide. Patients with DCM may present with common signs and symptoms of neurological dysfunction, such as paresthesia, abnormal gait, decreased hand dexterity, hyperreflexia, increased tone, and sensory dysfunction. Clinicians across several specialties encounter patients with DCM, including primary care physicians, rehabilitation specialists, therapists, rheumatologists, neurologists, and spinal surgeons...
September 2017: Global Spine Journal
https://www.readbyqxmd.com/read/29163927/nickel-catalyzed-asymmetric-hydrogenation-of-%C3%AE-acylamino-nitroolefins-an-efficient-approach-to-chiral-amines
#14
Wenchao Gao, Hui Lv, Tonghuan Zhang, Yuhong Yang, Lung Wa Chung, Yun-Dong Wu, Xumu Zhang
An efficient approach for synthesizing chiral β-amino nitroalkanes has been developed via the Ni-catalyzed asymmetric hydrogenation of challenging β-amino nitroolefins under mild conditions, affording the desired products in excellent yields and with high enantioselectivities. This protocol had good compatibility with the wide substrate scope and a range of functional groups. The synthesis of chiral β-amino nitroalkanes on a gram scale has also been achieved. In addition, the reaction mechanism was elucidated using a combined experimental and computational study, and it involved acetate-assisted heterolytic H2 cleavage followed by 1,4-hydride addition and protonation to achieve the nitroalkanes...
September 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29163887/a-novel-peptide-stapling-strategy-enables-the-retention-of-ring-closing-amino-acid-side-chains-for-the-wnt-%C3%AE-catenin-signalling-pathway
#15
Ye Wu, Ye-Hua Li, Xiang Li, Yan Zou, Hong-Li Liao, Lei Liu, Ye-Guang Chen, Donald Bierer, Hong-Gang Hu
The all-hydrocarbon peptide stapling strategy has recently been extensively explored in drug discovery. There remains the potential for improvement regarding the retention of the amino acid side chains at the stapled positions. Herein, we describe a new series of amino acids that not only contain the native side chains, but also carry the alkenyl arms that are needed for the ring-closing stapling chemistry. We incorporate the new amino acids into a β-catenin-binding domain of Axin (469-482) and develop a new category of stapled peptides with the retention of the native side chains...
November 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29163010/an-axiology-of-information-security-for-futuristic-neuroprostheses-upholding-human-values-in-the-context-of-technological-posthumanization
#16
Matthew E Gladden
Previous works exploring the challenges of ensuring information security for neuroprosthetic devices and their users have typically built on the traditional InfoSec concept of the "CIA Triad" of confidentiality, integrity, and availability. However, we argue that the CIA Triad provides an increasingly inadequate foundation for envisioning information security for neuroprostheses, insofar as it presumes that (1) any computational systems to be secured are merely instruments for expressing their human users' agency, and (2) computing devices are conceptually and practically separable from their users...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29163007/from-mice-to-mole-rats-species-specific-modulation-of-adult-hippocampal-neurogenesis
#17
Maria K Oosthuizen
Rodent populations living in their natural environments have very diverse ecological and life history profiles that may differ substantially from that of conventional laboratory rodents. Free-living rodents show species-specific neurogenesis that are dependent on their unique biology and ecology. This perspective aims to illustrate the benefit of studying wild rodent species in conjunction with laboratory rodents. African mole-rats are discussed in terms of habitat complexity, social structures, and longevity...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29162669/non-labelled-lens-less-micro-endoscopic-approach-for-cellular-imaging-through-highly-scattering-media
#18
Omer Wagner, Aditya Pandya, Yoav Chemla, Hadar Pinhas, Irina Schelkanova, Asaf Shahmoon, Yossi Mandel, Alexandre Douplik, Zeev Zalevsky
We describe an imaging approach based on an optical setup made up of a miniature, lensless, minimally invasive endoscope scanning a sample and matching post processing techniques that enables enhanced imaging capabilities. The main scopes of this article are that this approach enables imaging beyond highly scattering medium and increases the resolution and signal to noise levels reaching single cell imaging. Our approach has more advantages over ordinary endoscope setups and other imaging techniques. It is not mechanically limited by a lens, the fiber can acquire images over long time periods (unlike current imaging methods such as OCT etc...
November 21, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29162130/toward-a-comprehensive-evidence-map-of-overview-of-systematic-review-methods-paper-1-purpose-eligibility-search-and-data-extraction
#19
Carole Lunny, Sue E Brennan, Steve McDonald, Joanne E McKenzie
BACKGROUND: Overviews of systematic reviews attempt to systematically retrieve and summarise the results of multiple systematic reviews. Methods for conducting, interpreting and reporting overviews are in their infancy. To date, there has been no evidence map of the methods used in overviews, thus making it difficult to determine the gaps and priorities for methods research. Our objectives were to develop and populate a comprehensive framework of methods for conducting, interpreting and reporting overviews (stage I) and to create an evidence map by mapping studies that have evaluated overview methods to the framework (stage II)...
November 21, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29162081/self-management-support-and-ehealth-for-patients-and-informal-caregivers-confronted-with-advanced-cancer-an-online-focus-group-study-among-nurses
#20
Vina N Slev, H Roeline W Pasman, Corien M Eeltink, Cornelia F van Uden-Kraan, Irma M Verdonck-de Leeuw, Anneke L Francke
BACKGROUND: Self-management by patients and informal caregivers confronted with advanced cancer is not self-evident. Therefore they might need self-management support from nurses. This article reports on nurses' perspectives on self-management support for people confronted with advanced cancer, and nurses' experiences with eHealth in this context. METHODS: Six online focus groups were organized, with a total of 45 Dutch nurses with different educational levels and working in different care settings...
November 21, 2017: BMC Palliative Care
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