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https://www.readbyqxmd.com/read/29334467/robot-assisted-upper-extremity-rehabilitation-for-cervical-spinal-cord-injuries-a-systematic-scoping-review
#1
Hardeep Singh, Janelle Unger, José Zariffa, Maureen Pakosh, Susan Jaglal, B Catharine Craven, Kristin E Musselman
Abstact Purpose: To provide an overview of the feasibility and outcomes of robotic-assisted upper extremity training for individuals with cervical spinal cord injury (SCI), and to identify gaps in current research and articulate future research directions. MATERIALS AND METHODS: A systematic search was conducted using Medline, Embase, PsycINFO, CCTR, CDSR, CINAHL and PubMed on June 7, 2017. Search terms included 3 themes: (1) robotics; (2) SCI; (3) upper extremity. Studies using robots for upper extremity rehabilitation among individuals with cervical SCI were included...
January 15, 2018: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/29334464/asymmetric-synthesis-of-secondary-and-tertiary-propargylic-alcohols-by-umpolung-of-acetylenic-sulfones-and-ortho-sulfinyl-carbanions
#2
Ricardo I Rodriguez, Elsie Ramírez, Francisco Yuste, Ruben Sanchez-Obregon, José Alemán
The generation of diasteromerically enriched secondary benzyl propargyl alcohols by the asymmetric addition of ortho-sulfinylbenzyl carbanions to sulfonylacetylene derivatives via formation of Csp-Csp3 bond is described. This reaction proceeds through an unusual α-attack (anti-Michael addition) of the ortho-sulfinylbenzyl carbanions, followed by elimination of the arylsulfonyl moiety. The scope of this alkynylation reaction is also discussed. Moreover, the development of a new approach for the synthesis of optically active tertiary benzylpropargyl alcohols is described, discussing the possible stereocourse of the reaction so as the influence of the ether 18-crown-6 and steric importance of acetylenic substituent...
January 15, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29334276/an-automatic-measure-of-progression-during-colonoscopy-correlates-to-patient-experienced-pain
#3
Louise Preisler, Mustafa Bulut, Morten Soendergaard Svendsen, Lars Bo Svendsen, Lars Konge
BACKGROUND: Colonoscopy screening and surveillance programs depend on patient's tolerable experience, which is associated with competence of the endoscopist. The Colonoscopy Progression Score (CoPS) is an automated tool based on recording of the Magnetic Scope Imager (MEI) picture in order to track progression. CoPS deliver a numeric score and a graphic map. A high score expresses a rapid and smooth progression. Aims of study were to explore the correlation between CoPS and patient experienced pain and to identity locations associated with pain...
January 15, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29334220/computational-design-synthesis-and-structure-property-evaluation-of-1-3-thiazole-based-colour-tunable-multiheterocyclic-small-organic-fluorophores-as-multifunctional-molecular-materials
#4
Rakesh Radhakrishnan, Kumaran G Sreejalekshmi
Probing chemical space of luminescent organic materials built on novel cores is highly imperative for its potential to expand the horizons of advanced functional materials. Small organic fluorophores possessing therapeutic traits can contribute to theranostics. We coupled computational and classical synthetic chemistry strategies for the rational design of 5-(hetero-2-yl)-1,3-thiazoles as colour tunable fluorophore core. With the aid of DFT and TD-DFT, we prove multiheterocyclic system built on thiazole-het core with three inherent tunable sites on thiazole (C2, C4 and C5) capable of accommodating panoply of substituents, as a multifunctional molecular materials' platform...
January 15, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29334186/natural-humic-acid-based-phototheranostic-agent
#5
Zhao-Hua Miao, Kai Li, Pei-Ying Liu, Zhenglin Li, Huanjie Yang, Qingliang Zhao, Manli Chang, Qingzhu Yang, Liang Zhen, Cheng-Yan Xu
Humic acids, a major constituent of natural organic carbon resources, are naturally formed through the microbial biodegradation of animal and plant residues. Due to numerous physiologically active groups (phenol, carboxyl, and quinone), the biomedical applications of humic acid have been already investigated across different cultures for several centuries or even longer. In this work, sodium humate, the sodium salt of humic acid, is explored as phototheranostic agent for light-induced photoacoustic imaging and photothermal therapy based on intrinsic absorption in the near-infrared region...
January 15, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29334093/three-component-difluoroalkylation-and-trifluoromethylthiolation-trifluoromethylselenolation-of-%C3%AF-bonds
#6
Bo-Sheng Zhang, Lu-Yao Gao, Zhe Zhang, Yu-Hua Wen, Yong-Min Liang
This report describes a new method for three-component difluoroalkylation and trifluoromethylthiolation/trifluoromethylselenolation of π-bonds via air-stable SCF3 and SeCF3 reagents as free-radical initiators of ethyl iododifluoroacetate. β-Proton elimination can be overcome effectively in this reaction system, and a broad substrate scope, including alkenes and alkynes, makes this approach practical and attractive.
January 15, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29333684/biocatalytic-synthesis-of-nitriles-through-dehydration-of-aldoximes-the-substrate-scope-of-aldoxime-dehydratases
#7
Tobias Betke, Jun Higuchi, Philipp Rommelmann, Keiko Oike, Taiji Nomura, Yasuo Kato, Yasuhisa Asano, Harald Gröger
Nitriles belong to the product classes, which are mostly needed and produced by the chemical industry, playing a major role in various industry segments ranging from high-volume low-price sectors such as polymers to low-volume high-price sectors such as the chiral pharma drugs. A common industrial technology for nitrile production is ammonoxidation as a gas phase reaction at high temperature. A further popular approach are substitution or addition reactions with hydrogen cyanide or derivatives thereof. A major drawback, however, is the very high toxicity of cyanide...
January 14, 2018: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29332786/recent-advances-and-developments-on-integrating-nanotechnology-with-chemiluminescence-assays
#8
REVIEW
Ashish Tiwari, S J Dhoble
Chemiluminescence (CL) techniques are extensively utilized for detection of analytes due to their high sensitivity, rapidity and selectivity. With the advent of nanotechnology and incorporation of the nanoparticles in the CL system has revolutionized the assays due to their unique optical and mechanical properties. Several CL-based reactions have been developed where these nanoparticle based CL sensors have evolved as excellent prospects for sensing in various analytical applications. This review article addresses the nanoparticles based CL detection system that are recently developed, the mechanisms has been summarized and the role of luminophors have been discussed...
April 1, 2018: Talanta
https://www.readbyqxmd.com/read/29332555/victim-empowerment-safety-and-perpetrator-accountability-through-collaboration-a-crisis-to-transformation-conceptual-model
#9
Jacquelyn W White, Holly C Sienkiewicz
This article describes the development of the Victim Empowerment, Safety, and Perpetrator Accountability through Collaboration (VESPAC) model based on a grounded theory analysis of congressionally mandated and permissible purpose areas for grants authorized by the Violence Against Women Act. These areas are reflective of ongoing and emerging needs of victims and agencies serving victims and are rooted in the expertise, insight, and concerns of those who work most closely with victims and perpetrators on a regular basis...
December 1, 2017: Violence Against Women
https://www.readbyqxmd.com/read/29332550/how-ending-impunity-for-conflict-related-sexual-violence-overwhelmed-the-un-women-peace-and-security-agenda-a-discursive-genealogy
#10
Niamh Reilly
The recent unprecedented focus on ending impunity for conflict-related sexual violence (CRSV) is positive in many respects. However, it has narrowed the scope of Security Council Resolution 1325 and the women, peace, and security (WPS) agenda it established in 2000. Through a critical discursive genealogy of the interrelation of two UN agendas-protection of civilians in armed conflict and women, peace, and security-the author traces how CRSV emerged as the defining issue of the latter while the transformative imperative of making women's participation central to every UN endeavor for peace and security has failed to gain traction...
June 1, 2017: Violence Against Women
https://www.readbyqxmd.com/read/29332213/survivorship-care-plan-outcomes-for-primary-care-physicians-cancer-survivors-and-systems-a-scoping-review
#11
REVIEW
Weston LaGrandeur, Julie Armin, Carol L Howe, Leila Ali-Akbarian
PURPOSE: With the focus on survivorship care-coordination between oncology and primary care providers (PCPs), there is a need to assess the research regarding the use of survivorship care plans (SCPs) and determine emerging research areas. We sought to find out how primary care physicians have been involved in the use of SCPs and determine SCP's effectiveness in improving care for cancer survivors. In this scoping review, we aimed to identify gaps in the current research and reveal opportunities for further research...
January 13, 2018: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29331973/family-focused-practices-in-addictions-a-scoping-review-protocol
#12
Toula Kourgiantakis, Rachelle Ashcroft
INTRODUCTION: Families are significantly impacted by addictions and family involvement in treatment can reduce the harms and can also improve treatment entry, treatment completion and treatment outcomes for the individual coping with an addiction. Although the benefits of family-focused practices in addictions have been documented, services continue to have an individual focus and research on this topic is also limited. The objective of this study is to map the extent, range and nature of evidence available examining family interventions in addictions and identify gaps to guide future research, policy and practice...
January 13, 2018: BMJ Open
https://www.readbyqxmd.com/read/29331664/children-exhibit-different-performance-patterns-in-explicit-and-implicit-theory-of-mind-tasks
#13
Nese Oktay-Gür, Alexandra Schulz, Hannes Rakoczy
Three studies tested scope and limits of children's implicit and explicit theory of mind. In Studies 1 and 2, three- to six-year-olds (N = 84) were presented with closely matched explicit false belief tasks that differed in whether or not they required an understanding of aspectuality. Results revealed that children performed equally well in the different tasks, and performance was strongly correlated. Study 3 tested two-year-olds (N = 81) in implicit interactive versions of these tasks and found evidence for dis-unity: children performed competently only in those tasks that did not require an understanding of aspectuality...
January 11, 2018: Cognition
https://www.readbyqxmd.com/read/29331276/analyzing-recommender-systems-for-health-promotion-using-a-multidisciplinary-taxonomy-a-scoping-review
#14
Santiago Hors-Fraile, Octavio Rivera-Romero, Francine Schneider, Luis Fernandez-Luque, Francisco Luna-Perejon, Anton Civit-Balcells, Hein de Vries
BACKGROUND: Recommender systems are information retrieval systems that provide users with relevant items (e.g., through messages). Despite their extensive use in the e-commerce and leisure domains, their application in healthcare is still in its infancy. These systems may be used to create tailored health interventions, thus reducing the cost of healthcare and fostering a healthier lifestyle in the population. OBJECTIVE: This paper identifies, categorizes, and analyzes the existing knowledge in terms of the literature published over the past 10 years on the use of health recommender systems for patient interventions...
December 28, 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29331258/clinician-user-involvement-in-the-real-world-designing-an-electronic-tool-to-improve-interprofessional-communication-and-collaboration-in-a-hospital-setting
#15
Terence Tang, Morgan E Lim, Elizabeth Mansfield, Alexander McLachlan, Sherman D Quan
OBJECTIVES: User involvement is vital to the success of health information technology implementation. However, involving clinician users effectively and meaningfully in complex healthcare organizations remains challenging. The objective of this paper is to share our real-world experience of applying a variety of user involvement methods in the design and implementation of a clinical communication and collaboration platform aimed at facilitating care of complex hospitalized patients by an interprofessional team of clinicians...
February 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29331254/technology-alignment-in-the-presence-of-regulatory-changes-the-case-of-meaningful-use-of-information-technology-in-healthcare
#16
Anand Nair, David Dreyfus
OBJECTIVES: Using the context of the healthcare sector, this study examines the impact of regulatory change on technology implementation and use. Hospitals are now federally mandated to showcase meaningful use of information technology (IT). We theorize that IT plan scope structured prior to a regulatory change by means of a long-term planning horizon, top management involvement, and steering committee engagement impacts organizations' ability to fulfill meaningful use requirements three to five years later...
February 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29331124/characterizing-protein-conformations-by-correlation-analysis-of-coarse-grained-contact-matrices
#17
Richard J Lindsay, Jan Siess, David P Lohry, Trevor S McGee, Jordan S Ritchie, Quentin R Johnson, Tongye Shen
We have developed a method to capture the essential conformational dynamics of folded biopolymers using statistical analysis of coarse-grained segment-segment contacts. Previously, the residue-residue contact analysis of simulation trajectories was successfully applied to the detection of conformational switching motions in biomolecular complexes. However, the application to large protein systems (larger than 1000 amino acid residues) is challenging using the description of residue contacts. Also, the residue-based method cannot be used to compare proteins with different sequences...
January 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29330676/quantitative-outcomes-of-a-one-health-approach-to-study-global-health-challenges
#18
REVIEW
Laura C Falzon, Isabel Lechner, Ilias Chantziaras, Lucie Collineau, Aurélie Courcoul, Maria-Eleni Filippitzi, Riikka Laukkanen-Ninios, Carole Peroz, Jorge Pinto Ferreira, Merel Postma, Pia G Prestmo, Clare J Phythian, Eleonora Sarno, Gerty Vanantwerpen, Timothée Vergne, Douglas J C Grindlay, Marnie L Brennan
Having gained momentum in the last decade, the One Health initiative promotes a holistic approach to address complex global health issues. Before recommending its adoption to stakeholders, however, it is paramount to first compile quantitative evidence of the benefit of such an approach. The aim of this scoping review was to identify and summarize primary research that describes monetary and non-monetary outcomes following adoption of a One Health approach. An extensive literature search yielded a total of 42,167 references, of which 85 were included in the final analysis...
January 12, 2018: EcoHealth
https://www.readbyqxmd.com/read/29330247/frequency-and-criticality-of-diagnoses-in-family-medicine-practices-from-the-national-ambulatory-medical-care-survey-namcs
#19
Michael R Peabody, Thomas R O'Neill, Keith L Stelter, James C Puffer
BACKGROUND: Family medicine is a specialty of breadth, providing comprehensive health care for the individual and the family that integrates the broad scope of clinical, social, and behavioral sciences. As such, the scope of practice (SOP) for family medicine is extensive; however, over time many family physicians narrow their SOP. We sought to provide a nationally representative description of the most common and the most critical diagnoses that family physicians see in their practice...
January 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29329988/rethinking-medicaid-coverage-and-payment-policy-to-promote-high-value-care-the-case-of-long-acting-reversible-contraception
#20
Veronica X Vela, Elizabeth W Patton, Darshak Sanghavi, Susan F Wood, Peter Shin, Sara Rosenbaum
CONTEXT: Long-acting reversible contraception (LARC) is the most effective reversible method to prevent unplanned pregnancies. Variability in state-level policies and the high cost of LARC could create substantial inconsistencies in Medicaid coverage, despite federal guidance aimed at enhancing broad access. This study surveyed state Medicaid payment policies and outreach activities related to LARC to explore the scope of services covered. METHODS: Using publicly available information, we performed a content analysis of state Medicaid family planning and LARC payment policies...
January 9, 2018: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
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