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https://www.readbyqxmd.com/read/28528289/platelet-hyperactivation-apoptosis-and-hypercoagulability-in-patients-with-acute-pulmonary-embolism
#1
Samin Rezania, Michael A Puskarich, Daniela N Petrusca, Evandro M Neto-Neves, Matthew T Rondina, Jeffrey A Kline
Changes in systemic redox balance can alter platelet activation and aggregation. Acute pulmonary embolism (PE) is a systematic inflammatory disease associated with mechanical shear stress, increased thrombin, catecholamines, serotonin and hemolysis, which cumulatively can hyperactivate platelets and accelerate their turnover. We tested the hypothesis that platelets from patients with moderately severe PE will show hyperstimulation and a pre-apoptotic phenotype associated with microparticles (MPs) in plasma...
May 13, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28528079/the-lateral-habenula-and-the-serotonergic-system
#2
REVIEW
Martin Metzger, Debora Bueno, Leandro B Lima
The habenula (Hb) is an epithalamic structure differentiated into two nuclear complexes, medial (MHb) and lateral habenula (LHb). After decades of relative neglect, interest in the Hb resurged when it was demonstrated that LHb neurons play a key role in encoding disappointments and expectation of punishments. Consistent with such a role, the LHb has been implicated in a broad array of functions and pathologic conditions, notably in mechanisms of stress and pain, as well as in the pathophysiology of mood disorders...
May 17, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28526812/soluble-axl-is-an-accurate-biomarker-of-cirrhosis-and-hepatocellular-carcinoma-development-results-from-a-large-scale-multicenter-analysis
#3
Mirko Dengler, Katharina Staufer, Heidemarie Huber, Rudolf Stauber, Heike Bantel, Karl Heinz Weiss, Patrick Starlinger, Hannelore Pock, Petra Klöters-Plachky, Daniel N Gotthardt, Peter Rauch, Carolin Lackner, Judith Stift, Christine Brostjan, Thomas Gruenberger, Takashi Kumada, Hidenori Toyoda, Toshifumi Tada, Thomas S Weiss, Michael Trauner, Wolfgang Mikulits
Patients with chronic liver disease (CLD) and cirrhosis are at high risk for hepatocellular carcinoma (HCC). Current diagnostic tools for HCC detection include imaging techniques and serum biomarkers such as α-fetoprotein (AFP). Yet, these methods are limited in sensitivity and specificity to accurately detect early HCC. Here we focused on the potential of soluble Axl (sAxl) as a biomarker in CLD patients by analyzing serum samples of 1067 patients and healthy controls from centers in Europe and Asia. We show that serum concentrations of sAxl were significantly increased at early (82...
May 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28526553/hypothalamic-regulation-of-the-sleep-wake-cycle
#4
REVIEW
Daisuke Ono, Akihiro Yamanaka
Sleep is one of the most important physiological functions in mammals. It is regulated by not only homeostatic regulation but also circadian clock. Several neuropeptide-producing neurons located in the hypothalamus are implicated in the regulation of sleep/wakefulness. Among them, orexin/hypocretin-producing neurons (orexin neurons) are a crucial component for maintenance of wakefulness, because lack of orexin function results in narcolepsy, which is a sleep disorder. Recent findings have identified substances that excite or inhibit neural activity of orexin neurons...
May 16, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/28522426/polymer-coated-mucoadhesive-liposomes-intended-for-the-management-of-xerostomia
#5
Małgorzata I Adamczak, Ørjan G Martinsen, Gro Smistad, Marianne Hiorth
The aim of this work was to prepare and test different pharmaceutical formulations in respect of their potential in relieving dry mouth symptom. Since many of the products available on the market provide only temporary relief to the patients, there is need for new formulations able to retain on the oral mucosa. The prolonged moisture protection could be achieved by combining mucoadhesive materials, such as polymers containing hydrogen bonding groups, with vesicles capable of releasing hydration medium from the inner compartment...
May 15, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28522246/patient-obesity-influences-pelvic-lift-during-cup-insertion-in-total-hip-arthroplasty-through-a-lateral-transgluteal-approach-in-supine-position
#6
Steffen Brodt, Dimitri Nowack, Benjamin Jacob, Linda Krakow, Christoph Windisch, Georg Matziolis
BACKGROUND: Movement of the pelvis during implantation of total hip arthroplasty (THA) has a major influence on the positioning of the acetabular cup. Strong traction caused by retractors leads to iatrogenic pelvic lift and can thus be partly responsible for cup malpositioning. The objective of this study was to investigate such factors that influence pelvic lift. METHODS: The dynamic movement of the pelvis was measured during implantation of THA in 67 patients...
April 21, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28522193/ph-triggered-re-assembly-of-nanosphere-to-nanofiber-the-role-of-peptide-conformational-change-for-enhanced-cancer-therapy
#7
Peiqing Liang, Junjiong Zheng, Shulin Dai, Jiayu Wang, Zhaoqing Zhang, Ting Kang, Changyun Quan
pH-triggered conformational change and subsequent re-assembly of nanostructures provide a new strategy in nanomedicine for controlled drug release and enhanced therapy. Here, we reported the development of a novel pH-responsive nano-assembly as a drug carrier from peptide amphiphile (PA) consisting of mimicking peptide and stearic acid moieties. The mimicking peptide is a basic 17-amino acid peptide derived from antennapedia homeodomain, and undergoes a conformational transition of the secondary structure from β-sheet at pH7...
May 15, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28521347/sequential-extradural-release-of-the-v3-vertebral-artery-to-facilitate-intradural-v4-vertebral-artery-reanastomosis-feasibility-of-a-novel-revascularization-technique
#8
Ali Tayebi Meybodi, Michael T Lawton, Arnau Benet
BACKGROUND: Revascularization of the intradural vertebral artery (VA) usually involves V3-V4 bypass using an interposition graft. The interposition of a graft increases surgical time, adds risks, and requires 2 suture lines. OBJECTIVE: To assess the feasibility of an excision-reanastomosis of V4 by sequentially releasing V3. METHODS: Twenty specimens were prepared for surgical simulation of a far-lateral approach. The third and fourth segments of the VA were exposed through the far-lateral approach bilaterally...
June 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28520937/atypical-endocannabinoid-signaling-initiates-a-new-form-of-memory-related-plasticity-at-a-cortical-input-to-hippocampus
#9
Weisheng Wang, Yousheng Jia, Danielle T Pham, Linda C Palmer, Kwang-Mook Jung, Conor D Cox, Gavin Rumbaugh, Daniele Piomelli, Christine M Gall, Gary Lynch
Endocannabinoids (ECBs) depress transmitter release at sites throughout the brain. Here, we describe another form of ECB signaling that triggers a novel form of long-term potentiation (LTP) localized to the lateral perforant path (LPP) which conveys semantic information from cortex to hippocampus. Two cannabinoid CB1 receptor (CB1R) signaling cascades were identified in hippocampus. The first is pregnenolone sensitive, targets vesicular protein Munc18-1 and depresses transmitter release; this cascade is engaged by CB1Rs in Schaffer-Commissural afferents to CA1 but not in the LPP, and it does not contribute to LTP...
May 17, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28520711/inhalational-chlorine-injuries-at-public-aquatic-venues-california-2008-2015
#10
Jason A Wilken, Michele DiMaggio, Matthew Kaufmann, Kevin O'Connor, Svetlana Smorodinsky, Christina Armatas, Tracy Barreau, Richard Kreutzer, Lino Ancheta
In June 2015, personnel from California's Contra Costa Health Services Environmental Health and Hazardous Materials (hazmat) divisions were alerted to a possible chemical release at a swimming pool in an outdoor municipal water park. Approximately 50 bathers were in the pool when symptoms began; 34 (68%) experienced vomiting, coughing, or eye irritation. Among these persons, 17 (50%) were treated at the scene by Contra Costa's Emergency Medical Services (EMS) and released, and 17 (50%) were transported to local emergency departments; five patients also were evaluated later at an emergency department or by a primary medical provider...
May 19, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28516456/description-of-embryonic-development-and-ultrastructure-in-miracidia-of-cardiocephaloides-longicollis-digenea-strigeidae-in-relation-to-active-host-finding-strategy-in-a-marine-environment
#11
Ana Born-Torrijos, Astrid S Holzer, Juan A Raga, Gabrielle S van Beest, Aneta Yoneva
The functional ultrastructure and embryonic development of miracidia in naturally released eggs of the trematode Cardiocephaloides longicollis were studied using light and transmission electron microscopy. This species has operculated eggs and embryogenesis occurs in the marine environment before an actively infecting ciliated miracidium hatches. Six different developmental stages were identified. The lack of pores in the eggshell indicates its impermeability and the miracidium's dependency on glycogen nutritive reserves, contained in numerous vitellocytes in early embryos...
May 17, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/28509375/chronic-nicotine-induced-changes-in-gene-expression-of-delta-and-kappa-opioid-receptors-and-their-endogenous-ligands-in-the-mesocorticolimbic-system-of-the-rat
#12
Muzeyyen Ugur, Egemen Kaya, Oguz Gozen, Ersin O Koylu, Lutfiye Kanit, Aysegul Keser, Burcu Balkan
Delta and kappa opioid receptors (DOR and KOR, respectively) and their endogenous ligands, proenkephalin (PENK) and prodynorphin (PDYN)-derived opioid peptides are proposed as important mediators of nicotine reward. The present study investigated the regulatory effect of chronic nicotine treatment on the gene expression of DOR, KOR, PENK and PDYN in the mesocorticolimbic system. Three groups of rats were injected subcutaneously with nicotine at doses of 0.2, 0.4 or 0.6 mg/kg/day for six days. Rats were decapitated one hour after the last dose on day six, as this timing coincides with increased dopamine release in the mesocorticolimbic system...
May 16, 2017: Synapse
https://www.readbyqxmd.com/read/28506871/the-role-of-hyaluronan-as-a-drug-carrier-to-enhance-the-bioavailability-of-extended-release-ophthalmic-formulations-hyaluronan-timolol-ionic-complexes-as-a-model-case
#13
F D Battistini, L I Tártara, C Boiero, M L Guzmán, L C Luciani-Giaccobbe, S D Palma, D A Allemandi, R H Manzo, M E Olivera
The aim of this work was to obtain information concerning the properties of ophthalmic formulations based on hyaluronic-drug ionic complexes, to identify the factors that determine the onset, intensity and duration of the pharmacotherapeutic effect. Dispersions of a complex of 0.5% w/v of sodium hyaluronate (HyNa) loaded with 0.5% w/v of timolol maleate (TM) were obtained and presented a counterionic condensation higher than 75%. For comparison a similar complex obtained with hyaluronic acid (HyH) was also prepared...
May 12, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28505884/experimental-studies-on-combustion-of-composite-biomass-pellets-in-fluidized-bed
#14
Feihong Guo, Zhaoping Zhong
This work presents studies on the combustion of Composite Biomass Pellets (CBPS) in fluidized bed using bauxite particles as the bed material. Prior to the combustion experiment, cold-flow characterization and thermogravimetric analysis are performed to investigate the effect of air velocity and combustion mechanism of CBPS. The cold-state test shows that CBPs and bauxite particles fluidize well in the fluidized bed. However, because of the presence of large CBPs, optimization of the fluidization velocity is rather challenging...
May 11, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28503289/the-three-portal-technique-in-arthroscopic-lateral-epicondylitis-release
#15
Ashok Gowda, Gannon Kennedy, Stacey Gallacher, Jennie Garver, Theodore Blaine
Lateral epicondylitis, commonly referred to as tennis elbow, is a syndrome characterized by pain over the origin of the common extensor muscles of the fingers, hand and wrist at the lateral epicondyle. Reports of 70-90% response to conservative treatment at one year have been documented in the literature though refractory cases often require surgical management. Arthroscopic treatment of lateral epicondylitis allows for intra-articular visualization for concomitant pathology and localization of the Extensor Carpi Radialis Brevis tendon...
November 17, 2016: Orthopedic Reviews
https://www.readbyqxmd.com/read/28501222/medial-patellar-instability-a-systematic-review-of-the-literature-of-outcomes-after-surgical-treatment
#16
REVIEW
Gilbert Moatshe, Mark E Cinque, Bradley M Kruckeberg, Jorge Chahla, Robert F LaPrade
PURPOSE: To perform a systematic review of literature reporting on outcomes after surgical treatment of medial patellar instability. METHODS: A systematic review was performed according to PRISMA guidelines. Inclusion criteria were as follows: the outcomes and complications of medial patellar instability repair with a follow-up greater than 12 months, English language, and human studies. We excluded cadaveric studies, animal studies, basic science articles, editorial articles, review articles, and surveys...
May 10, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28500503/expression-and-localization-of-myosin-vi-in-developing-mouse-spermatids
#17
Przemysław Zakrzewski, Robert Lenartowski, Maria Jolanta Rędowicz, Kathryn G Miller, Marta Lenartowska
Myosin VI (MVI) is a versatile actin-based motor protein that has been implicated in a variety of different cellular processes, including endo- and exocytic vesicle trafficking, Golgi morphology, and actin structure stabilization. A role for MVI in crucial actin-based processes involved in sperm maturation was demonstrated in Drosophila. Because of the prominence and importance of actin structures in mammalian spermiogenesis, we investigated whether MVI was associated with actin-mediated maturation events in mammals...
May 12, 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28499809/an-emerging-role-for-the-lateral-habenula-in-aggressive-behavior
#18
REVIEW
Meghan Flanigan, Hossein Aleyasin, Aki Takahashi, Sam A Golden, Scott J Russo
Inter-male aggression is an essential component of social behavior in organisms from insects to humans. However, when expressed inappropriately, aggression poses significant threats to the mental and physical health of both the aggressor and the target. Inappropriate aggression is a common feature of numerous neuropsychiatric disorders in humans and has been hypothesized to result from the atypical activation of reward circuitry in response to social targets. The lateral habenula (LHb) has recently been identified as a major node of the classical reward circuitry and inhibits the release of dopamine from the midbrain to signal negative valence...
May 9, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28499127/3d-printed-scaffolds-with-synergistic-effect-of-hollow-pipe-structure-and-bioactive-ions-for-vascularized-bone-regeneration
#19
Wenjie Zhang, Chun Feng, Guangzheng Yang, Guanglong Li, Xun Ding, Shaoyi Wang, Yuandong Dou, Zhiyuan Zhang, Jiang Chang, Chengtie Wu, Xinquan Jiang
Segmental bone regeneration remains a considerable challenge due to the associated low degree of vascularization. To solve this problem, in this study, hollow-pipe-packed silicate bioceramic (BRT-H) scaffolds are fabricated using a coaxial three-dimensional (3D) printing technique. Based on a modified core/shell printer nozzle and a modulated viscoelastic bioceramic paste, hollow struts with an external diameter of 1 mm and internal dimeter of 500 μm can be directly printed, yielding a compressive strength of the BRT-H scaffolds as high as 26 MPa...
May 3, 2017: Biomaterials
https://www.readbyqxmd.com/read/28495506/use-of-bipedicled-dorsal-penile-flap-with-z-release-incision-a-new-option-in-redo-hypospadias-surgery
#20
Hazem Elmoghazy
OBJECTIVES: To solve the challenge in redo hypospadias surgery; we tried the use of bipedicled dorsal penile flap with Z release incision in failed hypospadias cases and reported the outcome. MATERIAL AND METHODS: Thirty male children with 3 or 4 previous unsuccessful hypospadias surgeries were included in our study. Our technique was done after at least 6 month from the last surgery. A flap of the dorsal penile skin is preserved and the skin lateral is dissected on each side...
May 8, 2017: Urology
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