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https://www.readbyqxmd.com/read/28224816/protective-effect-of-curcumin-against-myocardium-injury-in-ischemia-reperfusion-rats
#1
HuaJin Liu, ChangHua Wang, Zengyong Qiao, Yawei Xu
CONTEXT: Curcumin has long been used as a condiment and a traditional medicine worldwide. OBJECTIVE: The current study investigates the possible protective effect of curcumin on heart function in myocardium ischemia-reperfusion (MIR) rats. MATERIALS AND METHODS: We fed Sprague-Dawley (SD) rats (10 in each group) either curcumin (10, 20 or 30 mg/kg/d) or saline. Twenty days later, the rats were subjected to myocardial injuries by ligating the left anterior descending coronary artery (60 min), and subsequently, the heart (3 h) reperfused by releasing the ligation...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28224199/mechanically-aligned-total-knee-arthroplasty-carries-a-risk-of-bony-gap-changes-and-flexion-extension-axis-displacement
#2
Yasuo Niki, Tomoki Sassa, Katsuya Nagai, Kengo Harato, Shu Kobayashi, Taro Yamashita
PURPOSE: The flexion-extension axis (FEA) of the femur is substantially changed after mechanically aligned total knee arthroplasty (TKA) due to a discrepancy in bone cut thickness between the posterior and distal femoral regions. This study assessed the bony gap changes and FEA displacement caused by this problem in osteoarthritis patients. METHODS: The study enrolled 60 knees from 60 patients for whom primary TKA was planned due to medial knee osteoarthritis. All patients underwent computed tomography, and 3-dimensional (3D) bone models were reconstructed on 3D-planning software...
February 21, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28224075/endoscopic-trochanteric-bursectomy-and-iliotibial-band-release-for-persistent-trochanteric-bursitis
#3
Justin J Mitchell, Jorge Chahla, Alexander R Vap, Travis J Menge, Eduardo Soares, Jonathan M Frank, Chase S Dean, Marc J Philippon
Lateral hip pain associated with trochanteric bursitis is a common orthopedic condition, and can be debilitating in chronic or recalcitrant situations. Conservative management is the most common initial treatment and often results in resolution of symptoms and improved patient outcomes. These modalities include rest, activity modification, physical therapy, anti-inflammatory medication, or corticosteroid injections. However, there is a subset of patients in which symptoms persist despite exhaustive conservative modalities...
October 2016: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28220796/beyond-the-classic-vta-extended-amygdala-projections-to-da-striatal-paths-in-the-primate
#4
Julie L Fudge, Emily A Kelly, Ria Pal, Joseph L Bedont, Lydia Park, Brian Ho
The central extended amygdala (CEA) has been conceptualized as a 'macrosystem' that regulates various stress-induced behaviors. Consistent with this, the CEA highly expresses corticotropin releasing factor (CRF), an important modulator of stress responses. Stress alters goal-directed responses associated with striatal paths, including maladaptive responses such as drug seeking, social withdrawal, and compulsive behavior. CEA inputs to the midbrain dopamine (DA) system are positioned to influence striatal functions through mesolimbic DA-striatal pathways...
February 21, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28220074/involvement-of-cannabinoid-signaling-in-vincristine-induced-gastrointestinal-dysmotility-in-the-rat
#5
Gema Vera, Ana E López-Pérez, José A Uranga, Rocío Girón, Ma Isabel Martín-Fontelles, Raquel Abalo
Background: In different models of paralytic ileus, cannabinoid receptors are overexpressed and endogenous cannabinoids are massively released, contributing to gastrointestinal dysmotility. The antitumoral drug vincristine depresses gastrointestinal motility and a similar mechanism could participate in this effect. Therefore, our aim was to determine, using CB1 and CB2 antagonists, whether an increased endocannabinoid tone is involved in vincristine-induced gastrointestinal ileus. Methods: First, we confirmed the effects of vincristine on the gut mucosa, by conventional histological techniques, and characterized its effects on motility, by radiographic means...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28219642/synergy-of-raddeanin-a-and-cisplatin-induced-therapeutic-effect-enhancement-in-human-hepatocellular-carcinoma
#6
Li Jian-Nan, Yu Ye, Zhang Yan-Fei, Li Zhi-Meng, Cai Guang-Zhi, Gong Ji-Yu
Cisplatin is a main compound for human hepatocellular carcinoma (HCC) chemotherapies, but it has certain cytotoxicity during applications. To release that, combining with other drugs are being as a regular plan in clinic. In our present study, we are focusing on one of active monomers extracted from Anemone Raddeana Regel, Raddeanin A (RA), which is on behalf of the same character like cisplatin in the tumor remedies. In order to investigate whether combination usage of RA and cisplatin can be priority to the later drug's effect development and its toxicity reduction in HCC, both of two drugs were treated 24 h or 48 h in QGY-7703 cells for estimating their abilities in tumor cell proliferation inhibition...
February 17, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28215749/steady-state-centrifugal-input-via-the-lateral-olfactory-tract-modulates-spontaneous-activity-in-the-rat-main-olfactory-bulb
#7
Neil C Ford, Edwin R Griff
Mitral and tufted cells in the main olfactory bulb (MOB) of anesthetized rats exhibit vigorous spontaneous activity, action potentials produced in the absence of odor stimuli. The central hypothesis of this paper is that tonic activity of centrifugal input to the MOB modulates the spontaneous activity of MOB neurons. The spontaneous activity of centrifugal fibers causes a baseline of steady-state neurotransmitter release, and odor stimulation produces transient changes in the resulting spontaneous activity...
February 16, 2017: Neuroscience
https://www.readbyqxmd.com/read/28215300/the-role-of-neurotrophins-in-inflammation-and-allergy
#8
S Manti, P Brown, M K Perez, G Piedimonte
Allergic inflammation is the result of a specific pattern of cellular and humoral responses leading to the activation of the innate and adaptive immune system, which, in turn, results in physiological and structural changes affecting target tissues such as the airways and the skin. Eosinophil activation and the production of soluble mediators such as IgE antibodies are pivotal features in the pathophysiology of allergic diseases. In the past few years, however, convincing evidence has shown that neurons and other neurosensory structures are not only a target of the inflammatory process but also participate in the regulation of immune responses by actively releasing soluble mediators...
2017: Vitamins and Hormones
https://www.readbyqxmd.com/read/28214875/a-developmental-study-of-the-cerebellar-nucleus-in-the-catshark-a-basal-gnathostome
#9
Sol Pose-Méndez, Isabel Rodríguez-Moldes, Eva Candal, Sylvie Mazan, Ramón Anadón
The output of the cerebellar cortex is mainly released via cerebellar nuclei which vary in number and complexity among gnathostomes, extant vertebrates with a cerebellum. Cartilaginous fishes, a basal gnathostome lineage, show a conspicuous, well-organized cerebellar nucleus, unlike ray-finned fishes. To gain insight into the evolution and development of the cerebellar nucleus, we analyzed in the shark Scyliorhinus canicula (a chondrichthyan model species) the developmental expression of several genes coding for transcription factors (ScLhx5,ScLhx9,ScTbr1, and ScEn2) and the distribution of the protein calbindin, since all appear to be involved in cerebellar nuclei patterning in other gnathostomes...
February 18, 2017: Brain, Behavior and Evolution
https://www.readbyqxmd.com/read/28213152/central-neuronal-motor-behaviour-in-skilled-and-less-skilled-novices-approaching-sports-specific-movement-techniques
#10
Tobias Vogt, Kouki Kato, Stefan Schneider, Stefan Türk, Kazuyuki Kanosue
Research on motor behavioural processes preceding voluntary movements often refers to analysing the readiness potential (RP). For this, decades of studies used laboratory setups with controlled sports-related actions. Further, recent applied approaches focus on athlete-non-athlete comparisons, omitting possible effects of training history on RP. However, RP preceding real sport-specific movements in accordance to skill acquisition remains to be elucidated. Therefore, after familiarization 16 right-handed males with no experience in archery volunteered to perform repeated sports-specific movements, i...
February 14, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28212523/redox-regulation-in-metabolic-programming-and-inflammation
#11
REVIEW
Helen R Griffiths, Dan Gao, Chathyan Pararasa
Energy metabolism and redox state are intrinsically linked. In order to mount an adequate immune response, cells must have an adequate and rapidly available energy resource to migrate to the inflammatory site, to generate reactive oxygen species using NADPH as a cofactor and to engulf bacteria or damaged tissue. The first responder cells of the innate immune response, neutrophils, are largely dependent on glycolysis. Neutrophils are relatively short-lived, dying via apoptosis in the process of bacterial killing through production of hypochlorous acid and release of extracellular NETs...
February 12, 2017: Redox Biology
https://www.readbyqxmd.com/read/28202890/a-case-of-upside-down-stomach-that-was-effectively-treated-by-postprandial-repositioning
#12
Kazumasa Ono, Hiroshi Hasegawa, Toshimasa Obara, Kei Miyagishima, Shinichiro Inoue, Koichi Kozaki
An 88-year-old woman with a history of stomach perforation and lumbar compression fracture was admitted to our hospital with a chief complaint of continuous vomiting, which she had experienced since the previous day. She showed vomiting, spontaneous pain and tenderness from the epigastric fossa through the left flank. In addition, she had marked kyphosis. On a CT scan, although the fornix was located in the abdominal cavity, the antrum and body had escaped into the thoracic cavity. A large volume of gastric content was observed...
2017: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
https://www.readbyqxmd.com/read/28202702/congenital-myopathy-associated-with-the-triadin-knockout-syndrome
#13
Andrew G Engel, Keeley R Redhage, David J Tester, Michael J Ackerman, Duygu Selcen
OBJECTIVE: Triadin is a component of the calcium release complex of cardiac and skeletal muscle. Our objective was to analyze the skeletal muscle phenotype of the triadin knockout syndrome. METHODS: We performed clinical evaluation, analyzed morphologic features by light and electron microscopy, and immunolocalized triadin in skeletal muscle. RESULTS: A 6-year-old boy with lifelong muscle weakness had a triadin knockout syndrome caused by compound heterozygous null mutations in triadin...
February 15, 2017: Neurology
https://www.readbyqxmd.com/read/28199771/thyroid-dysfunction-in-children-with-autism-spectrum-disorder-is-associated-with-folate-receptor-alpha-autoimmune-disorder
#14
Richard E Frye, Rebecca Wynne, Shannon Rose, John Slattery, Leanna Delhey, Marie Tippett, Stephen G Kahler, Sirish C Bennuri, Stepan Melnyk, Jeffrey M Sequeira, Edward Quadros
Folate receptor α (FRα) autoantibodies (FRAAs) are prevalent in Autism Spectrum Disorder (ASD). FRAAs disrupt folate transport across the blood-brain barrier by binding to the FRα. Thyroid dysfunction is frequently found in children with ASD. We measured blocking and binding FRAAs and thyroid stimulating hormone (TSH), free T4 (FT4), total T3 (TT3), reverse T3 (rT3), thyroid releasing hormone (TRH) and other metabolites in 87 children with ASD, 84 of whom also underwent behavior and cognition testing and in 42 of whom FRAAs, TSH and FT4 were measured at two time points...
February 15, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28197694/relaxation-of-the-mcl-after-an-open-wedge-high-tibial-osteotomy-results-in-decreasing-contact-pressures-of-the-knee-over-time
#15
N van Egmond, G Hannink, D Janssen, A C Vrancken, N Verdonschot, A van Kampen
PURPOSE: The objective of this study was to investigate the effect of a medial open-wedge osteotomy (OWO) and the release of the superficial medial collateral ligament (MCL) on the tibiofemoral cartilage pressure, the MCL tension and the valgus laxity of the knee. METHODS: Seven fresh-frozen, human cadaveric knees were used. Medial and lateral mean contact pressure (CP), peak contact pressure (peakCP), and contact area (CA) were measured using a pressure-sensitive film (I-Scan; Tekscan, Boston, MA)...
February 15, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28197549/activation-dependent-rapid-postsynaptic-clustering-of-glycine-receptors-in-mature-spinal-cord-neurons
#16
Yoshihisa Nakahata, Kei Eto, Hideji Murakoshi, Miho Watanabe, Toshihiko Kuriu, Hiromi Hirata, Andrew J Moorhouse, Hitoshi Ishibashi, Junichi Nabekura
Inhibitory synapses are established during development but continue to be generated and modulated in strength in the mature nervous system. In the spinal cord and brainstem, presynaptically released inhibitory neurotransmitter dominantly switches from GABA to glycine during normal development in vivo. While presynaptic mechanisms of the shift of inhibitory neurotransmission are well investigated, the contribution of postsynaptic neurotransmitter receptors to this shift is not fully elucidated. Synaptic clustering of glycine receptors (GlyRs) is regulated by activation-dependent depolarization in early development...
January 2017: ENeuro
https://www.readbyqxmd.com/read/28197081/basal-forebrain-cholinergic-system-and-orexin-neurons-effects-on-attention
#17
REVIEW
Ines Villano, Antonietta Messina, Anna Valenzano, Fiorenzo Moscatelli, Teresa Esposito, Vincenzo Monda, Maria Esposito, Francesco Precenzano, Marco Carotenuto, Andrea Viggiano, Sergio Chieffi, Giuseppe Cibelli, Marcellino Monda, Giovanni Messina
The basal forebrain (BF) cholinergic system has an important role in attentive functions. The cholinergic system can be activated by different inputs, and in particular, by orexin neurons, whose cell bodies are located within the postero-lateral hypothalamus. Recently the orexin-producing neurons have been proved to promote arousal and attention through their projections to the BF. The aim of this review article is to summarize the evidence showing that the orexin system contributes to attentional processing by an increase in cortical acetylcholine release and in cortical neurons activity...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28196761/effect-of-gonadotropin-releasing-hormone-vaccination-on-t-lymphocyte-changes-in-male-rats
#18
Shiping Su, Xiuhong Zhou, Xiaorong Zhang, Fuigui Fang
The aim of this study was to detect the effect of immunization against gonadotropin-releasing hormone (GnRH) on cell-meditated immunity. Three-week-old male Sprague-Dawley rats (n=32) were randomly and equally assigned to two groups: 1) GnRH-tandem-ovalbumin immunized group; and 2) the control group (injected with an equivalent Al(OH)3 adjuvant). Blood samples were collected at two-week intervals to assess the level of GnRH-specific antibodies and testosterone. Moreover, blood and thymus samples were also collected to analyze the T lymphocyte subpopulations one and two months after the last booster immunization...
February 7, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28194383/clinical-evaluation-of-arthroscopic-treatment-of-shoulder-adhesive-capsulitis
#19
Alberto Naoki Miyazaki, Pedro Doneux Santos, Luciana Andrade Silva, Guilherme do Val Sella, Leonardo Carrenho, Sergio Luiz Checchia
OBJECTIVE: To evaluate the results of arthroscopic releases performed in patients with adhesive capsulitis refractory to conservative treatment. METHODS: This was a retrospective study, conducted between 1996 and 2012, which included 56 shoulders (52 patients) that underwent surgery; 38 were female, and 28 had the dominant side affected. The mean age was 51 (29-73) years. The mean follow-up was 65 (12-168) months and the mean preoperative time was 8.9 (2-24) months...
January 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28192820/estrogen-maintains-skeletal-muscle-in-septic-rats-associated-with-altering-hypothalamic-inflammation-and-neuropeptides
#20
Chenyan Zhao, Jun Li, Minhua Cheng, Jialing Shi, Juanhong Shen, Tao Gao, Fengchan Xi, Wenkui Yu
Muscle wasting is one of the main contributors to the worse outcomes in sepsis. Whether estrogen could alleviate muscle wasting induced by sepsis remains unclear. This study was designed to test the effect of estrogen on muscle wasting and its relationship with central alteration in sepsis. Thirty Sprague-Dawley rats were divided into 3 groups: control group, sepsis group, and estrogen treated sepsis group. Animals were intraperitoneally injected with lipopolysaccharide (10 mg/kg) or saline, followed by subcutaneous injection of 17β-estradiol (1 mg/kg) or saline...
February 13, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
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