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https://www.readbyqxmd.com/read/29454866/behavioral-toxicity-of-sodium-cyanide-following-oral-ingestion-in-rats-dose-dependent-onset-severity-survival-and-recovery
#1
Nathaniel C Rice, Noah A Rauscher, Jeffrey L Langston, Todd M Myers
Sodium cyanide (NaCN) is a commonly and widely used industrial and laboratory chemical reagent that is highly toxic. Its availability and rapid harmful/lethal effects combine to make cyanide a potential foodborne/waterborne intentional-poisoning hazard. Thus, laboratory studies are needed to understand the dose-dependent progression of toxicity/lethality following ingestion of cyanide-poisoned foods/liquids. We developed an oral-dosing method in which a standard pipette was used to dispense a sodium cyanide solution into the cheek, and the rat then swallowed the solution...
February 15, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29449954/metabotropic-glutamate-receptor-5-tracer-18-f-fpeb-displays-increased-binding-potential-in-postcentral-gyrus-and-cerebellum-of-male-individuals-with-autism-a-pilot-pet-study
#2
S Hossein Fatemi, Dean F Wong, James R Brašić, Hiroto Kuwabara, Anil Mathur, Timothy D Folsom, Suma Jacob, George M Realmuto, José V Pardo, Susanne Lee
Background: Autism is a neurodevelopmental disorder that is first manifested during early childhood. Postmortem experiments have identified significantly elevated expression of metabotropic glutamate receptor 5 (mGluR5) in cerebellar vermis and prefrontal cortex of individuals with autism. Methods: In the current study we employed the mGluR5 tracer [ 18 F]-3-fluoro-5-[(pyridin-3-yl)ethynyl]benzonitrile ([ 18 F]-FPEB) to quantify mGluR5 binding in vivo in adults with autism vs...
2018: Cerebellum & Ataxias
https://www.readbyqxmd.com/read/29446705/prospective-assessment-of-rhinovirus-symptoms-and-species-recurrence-in-children-with-and-without-an-acute-wheezing-exacerbation
#3
Robert Lethbridge, Franciska Prastanti, Cassandra Robertson, Stephen Oo, Siew-Kim Khoo, Peter N Le Souëf, Ingrid A Laing
To assess if the difference in species-specific immune response to RV-C correlates with a higher frequency of reinfection, shorter time to reinfection, or different symptom severity than infections with RV-A or RV-B. Forty-three patients were enrolled of which 34 were successfully tracked longitudinally over 3 months, with nasal swabs and symptom questionnaires provided every 2 weeks to identify rhinovirus (RV) strains and the concurrent symptomatology. No difference was found in the time to reinfection with an RV species between RV-C and RV-A or RV-B (p = 0...
February 15, 2018: Viral Immunology
https://www.readbyqxmd.com/read/29437805/food-protein-induced-enterocolitis-syndrome-a-challenging-diagnosis
#4
Andreia Ribeiro, Diana Moreira, Cristina Costa, Isabel Pinto Pais
Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated gastrointestinal food hypersensitivity triggered by food proteins. It may present acutely, with repetitive vomiting, diarrhoea and lethargy leading to dehydration and eventually shock or insidiously with intermittent emesis, chronic diarrhoea or failure to thrive. We describe a paediatric male patient with recurrent sepsis-like episodes of fever, lethargy, ashen-grey skin colouration and vomiting followed by diarrhoea. These episodes were triggered by cow's milk formula and grains...
February 8, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29437131/case-4-poor-feeding-and-lethargy-in-a-32-day-old-infant
#5
Erin R Peebles, Tamara A VanHooren, Anna C Gunz, Marina I Salvadori
No abstract text is available yet for this article.
February 2018: Pediatrics in Review
https://www.readbyqxmd.com/read/29436372/the-acupuncture-therapeutic-approach-in-temporal-arteritis-vasculitis-a-case-report
#6
Yılmaz Sezgin
Temporal arteritis is a form of vasculitis that involves the large and medium-diameter arteries and leads to progressive headache. Symptoms may be accompanied by vision disorder, subfebrile temperature, fatigue, lack of appetite, weight loss, sweating and joint pains. While cortisone therapy reduces the symptoms, its effects in terms of improving quality of life are limited. We elected to benefit from the effects of acupuncture in order to reduce symptoms and increase quality of life in a case of temporal arteritis, a chronic disease...
December 26, 2017: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/29434688/nalbuphine-for-analgesia-after-fracture-surgery-and-its-effect-on-circulating-inflammatory-factors
#7
Yong Gong, Yang Zhang, Shoujun Tao
The present study evaluated the use of nalbuphine for analgesia after fraction reduction surgery. Eighty lower limb fracture patients needing open reduction and internal fixation were selected in the First People's Hospital of Jingzhou from January 2015 to December 2015. Patients were randomly divided into observation and control groups (with 40 cases in each). After surgery, the patients in the observation group were treated with nalbuphine (2 mg/kg) for patient-controlled intravenous analgesia (PCIA), while sufentanil (2...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29431405/hyperosmolar-hyperglycemic-state
#8
Gregg D Stoner
Hyperosmolar hyperglycemic state is a life-threatening emergency manifested by marked elevation of blood glucose and hyperosmolarity with little or no ketosis. Although there are multiple precipitating causes, underlying infections are the most common. Other causes include certain medications, nonadherence to therapy, undiagnosed diabetes mellitus, substance abuse, and coexisting disease. In children and adolescents, hyperosmolar hyperglycemic state is often present when type 2 diabetes is diagnosed. Physical findings include profound dehydration and neurologic symptoms ranging from lethargy to coma...
December 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/29430859/rabies-risk-and-use-of-post-exposure-prophylaxis-associated-with-dog-bites-in-tennessee
#9
H Henderson, L R Carpenter, J R Dunn
The canine variant of the rabies virus has been eliminated in the United States. Among the public and many healthcare providers, however, dog bites are still associated with risk for rabies transmission. This study examined the risk of rabies in biting dogs and the use of rabies post-exposure prophylaxis (rPEP) for dog bite victims in Tennessee. The study included a retrospective analysis of laboratory testing requisitions for dogs from 2002 to 2016, collection of clinical data on confirmed rabies-positive dogs from 2008 to 2016 and analysis of hospital discharge data for rPEP from 2007 to 2014...
February 12, 2018: Zoonoses and Public Health
https://www.readbyqxmd.com/read/29429482/enteric-coronavirus-infection-in-adult-horses
#10
N Pusterla, R Vin, C M Leutenegger, L D Mittel, T J Divers
A new enteric virus of adult horses, equine coronavirus (ECoV), has recently been recognized. It is associated with fever, lethargy, anorexia, and less frequently, colic and diarrhea. This enteric virus is transmitted via the feco-oral route and horses become infected by ingesting fecally contaminated feed and water. Various outbreaks have been reported since 2010 from Japan, Europe and the USA. While the clinical signs are fairly non-specific, lymphopenia and neutropenia are often seen. Specific diagnosis is made by the detection of ECoV in feces by either quantitative real-time PCR, electron microscopy or antigen-capture ELISA...
January 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29428916/clinical-profile-of-neonates-with-hypernatremic-dehydration-hospitalized-in-an-outborn-neonatal-intensive-care-unit
#11
Smita Nair, Amitabh Singh, Mamta Jajoo
This retrospective observational study aimed to find the clinical profile of hypernatremic dehydration in neonates. 49 neonates (3.4% of the total admitted newborns) developed hypernatremic dehydration. The major presenting complaints were fever (34.6%), poor feeding (42.8%), loose stools (40.8%) and lethargy (26.5%). The time needed for correction of hypernatremia was 38.6 (±15.1) hours. Exclusively breastfed neonates had lesser complication rates of hypernatremic dehydration.
February 9, 2018: Indian Pediatrics
https://www.readbyqxmd.com/read/29416998/association-of-personal-hygiene-with-common-morbidities-among-upper-primary-school-children-in-rural-odisha
#12
Kalyan Kumar Paul, Sandeep Kumar Panigrahi, Arun Kiran Soodi Reddy, Trilochan Sahu
Context: In India, children of upper primary school receive less attention from health-care providers. The majority of their health problems are preventable through hygienic practices. Aims: The aim of this study was to find out the association of personal hygiene with common morbidities among upper primary school children. Settings and Design: A cross-sectional study conducted in a rural upper primary school of Odisha. Subjects and Methods: A semi-structured schedule based on the Global School Health Survey Questionnaire and necessary instruments for clinical examination were used...
July 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29412294/accuracy-of-the-defining-characteristics-in-nursing-diagnoses-of-hyperthermia-in-newborns
#13
Wislla Ketlly Menezes de Aquino, Marcos Venícios de Oliveira Lopes, Viviane Martins da Silva, Nathaly Bianka Moraes Fróes, Angélica Paixão de Menezes, Aline de Aquino Peres Almeida, Bianca Alves Sobreira
OBJECTIVE: to clinically validate the accuracy of the defining characteristics in nursing diagnoses of Hyperthermia in newborns. METHOD: a cross-sectional study conducted in units of medium and high risk in a maternity from the city of Fortaleza-CE. A total of 216 newborns were evaluated to identify the defining characteristics of diagnoses. A latent class model with random effects was used to measure sensitivity and specificity. RESULTS: Hyperthermia was present in 5...
March 2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29410974/bacteremia-and-septic-arthritis-due-to-a-nontoxigenic-strain-of-clostridium-difficile-in-a-patient-with-sickle-cell-disease
#14
Emilie Hill, Adrienne D Workman, Francesca Lee, Rita Hollaway, Dominick Cavuoti, Bonnie C Prokesch
A 22-year-old female with sickle cell disease presented with fevers, bilateral knee pain, and lethargy. Laboratory data revealed a leukocytosis and lactic acidosis. Blood and synovial fluid cultures grew a non-toxin-producing strain of Clostridium difficile. This case highlights the fact that nontoxigenic Clostridium difficile can cause significant disease.
February 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29403642/characterisation-of-the-french-ferret-population-husbandry-reported-medical-care-and-feeding-habits
#15
Géraldine Blanchard, Maud Marsot, Roselyne Bourassin, Bernard-Marie Paragon, Jean-Jacques Benet, Adeline Linsart
Ferrets have become a common companion animal. But no data are available on the French population of ferrets. The goal of the survey was to characterise this population, including demographic characteristics, husbandry, reported medical care and feeding habits. Complete data were available for 1205 pet ferrets in 709 households. Most ferrets (86·1 %) lived indoors, 1 % received only artificial lighting, and 47 % chewed their cage. For 60 % of the ferrets, body weight was higher in winter and lower in summer...
2018: Journal of Nutritional Science
https://www.readbyqxmd.com/read/29399368/successful-treatment-of-providencia-rettgeri-cholecystitis-and-neutrophilic-cholangitis-in-a-cat
#16
Patricia L Newton, Darren R Fry
Case summary: A 15-year-old male neutered domestic shorthair cat was presented with a recent history of seizures, diarrhoea, lethargy, fever and jaundice. Marked elevation of liver enzyme activity was present and ultrasound examination was suggestive of cholecystitis and hepatitis. Neutrophilic cholangitis was confirmed on histopathology of liver biopsies. Bile culture identified a monomicrobial infection with Providencia rettgeri, which was resistant to multiple antimicrobial agents...
January 2018: JFMS Open Reports
https://www.readbyqxmd.com/read/29393561/ultrasound-and-computed-tomography-of-sacculitis-and-appendicitis-in-a-rabbit
#17
Maurizio Longo, Florence Thierry, Kevin Eatwell, Tobias Schwarz, Jorge Del Pozo, Jenna Richardson
A 9-month-old neutered male rabbit was referred for lethargy, anorexia, and gastrointestinal stasis. Routine hematology, serum biochemistry, and diagnostic imaging were performed. Computed tomography revealed a wall thickening of the sacculus rotundus and appendix, which was further confirmed on abdominal ultrasound. Full thickness biopsies were collected with histopathology diagnosing a chronic multifocal heterophilic granulomatous sacculitis and appendicitis. The patient was treated medically and at 6 weeks follow-up, clinical signs and intestinal changes had completely regressed...
February 2, 2018: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29389909/women-s-ideas-about-the-health-effects-of-household-air-pollution-developed-through-focus-group-discussions-and-artwork-in-southern-nepal
#18
Delan Devakumar, Zeshan Qureshi, Jenevieve Mannell, Manju Baruwal, Neha Sharma, Eva Rehfuess, Naomi M Saville, Dharma S Manandhar, David Osrin
Household air pollution is a major cause of ill health, but few solutions have been effective to date. While many quantitative studies have been conducted, few have explored the lived experiences and perceptions of women who do the cooking, and as a result are those most exposed to household air pollution. In this study, we worked with groups of home cooks, and sought to use art as a means of engaging them in discussions of how household air pollution from cooking affects their lives. In the Terai district of southern Nepal, we held four focus groups that included 26 local women from urban and peri-urban areas, as well as six local artists...
February 1, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29384484/brevetoxin-exposure-in-sea-turtles-in-south-texas-usa-during-karenia-brevis-red-tide
#19
Jennifer Shelby Walker, Donna J Shaver, Brian A Stacy, Leanne J Flewelling, Margaret H Broadwater, Zhihong Wang
Five green (Chelonia mydas) and 11 Kemp's ridley (Lepidochelys kempii) sea turtles found dead, or that died soon after stranding, on the southern Texas (USA) coast during 2 Karenia brevis blooms (October 2015, September-October 2016) were tested for exposure to brevetoxins (PbTx). Tissues (liver, kidney) and digesta (stomach and intestinal contents) were analyzed by ELISA. Three green turtles found alive during the 2015 event and 2 Kemp's ridley turtles found alive during the 2016 event exhibited signs of PbTx exposure, including lethargy and/or convulsions of the head and neck...
January 31, 2018: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/29383824/clinical-therapeutic-efficacy-of-mycophenolate-mofetil-in-the-treatment-of-sards-in-dogs-a-prospective-open-label-pilot-study
#20
Whitney M Young, Annie Oh, Jonathan G Williams, Melanie L Foster, William W Miller, Katharine F Lunn, Freya M Mowat
OBJECTIVE: Sudden acquired retinal degeneration syndrome (SARDS) is a leading cause of irreversible blindness in dogs, yet no treatment has been objectively evaluated, or proven to be effective. Consensus of opinion is that SARDS is immune-mediated, although corticosteroid medications may exacerbate associated systemic signs. We examined the effect of sole-agent treatment with mycophenolate mofetil (MMF), a potent immunosuppressive medication unlikely to exacerbate associated systemic signs...
January 31, 2018: Veterinary Ophthalmology
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