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https://www.readbyqxmd.com/read/29766738/the-role-of-gene-editing-in-neurodegenerative-diseases
#1
Hueng-Chuen Fan, Ching-Shiang Chi, Yih-Jing Lee, Jeng-Dau Tsai, Shinn-Zong Lin, Horng-Jyh Harn
Neurodegenerative diseases (NDs), at least including Alzheimer's, Huntington's, and Parkinson's diseases, have become the most dreaded maladies because there are no precise diagnostic tools or definite treatments for these debilitating diseases. The increased prevalence and a substantial impact on the social-economic and medical care of NDs propel governments to develop policies to counteract the impact. Although the etiologies of NDs are still unknown, growing evidence suggests that genetic, cellular, and circuit alternations may cause the generation of abnormal misfolded proteins, which uncontrolledly accumulate to damage and eventually overwhelm the protein-disposal mechanisms of these neurons, leading to a common pathological feature of NDs...
January 1, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29750049/current-trends-in-needle-free-jet-injection-an-update
#2
REVIEW
Daniel Barolet, Antranik Benohanian
Background: Jet injection can be defined as a needle-free drug delivery method in which a high-speed stream of fluid impacts the skin and delivers a drug. Despite 75 years of existence, it never reached its full potential as a strategic tool to deliver medications through the skin. Objective: The aim of this review was to evaluate and summarize the evolution of jet injection intradermal drug delivery method including technological advancements and new indications for use...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29741867/tackling-poor-specificity-of-cocaine-color-tests-by-electrochemical-strategies
#3
Mats de Jong, Anca Florea, Joy Eliaerts, Filip Van Durme, Nele Samyn, Karolien De Wael
This paper presents electrochemical strategies for the fast screening of cocaine and most common cutting agents found in seized drug samples. First, a study on the performance of Scott color tests on cocaine and a wide range of cutting agents is described. The cutting agents causing false positive or false negative results when in mixture with cocaine are identified. To overcome the lack of specificity of color tests, we further propose a fast screening strategy by means of square wave voltammetry on disposable graphite screen printed electrodes, which reveals the unique fingerprint of cocaine and cutting agents...
May 9, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29728779/prevalence-of-selected-pharmaceuticals-in-surface-water-receiving-untreated-sewage-in-northwest-pakistan
#4
Aisha Khan, Dilawar Farhan Shams, Waliullah Khan, Aamir Ijaz, Muhammad Qasim, Maryam Saad, Ayesha Hafeez, Shams Ali Baig, Nisar Ahmed
This study investigated the occurrence of four non-steroidal anti-inflammatory drugs (NSAIDs) and four benzodiazepines/anti-depressants (ADs) in municipal wastewater in Mardan city, Pakistan, and in River Kabul and River Indus receiving untreated sewage. Liquid chromatography with a triple quadrupole tandem mass spectrometry (LC-MS/MS) was used for the analysis of paracetamol, diclofenac, ibuprofen, and codeine (NSAIDs) and diazepam, bromazepam, lorazepam, and temazepam (ADs). Except codeine and lorazepam, all the target compounds were observed in sewage and surface water in various concentrations...
May 4, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29727969/contamination-profiles-mass-loadings-and-sewage-epidemiology-of-neuropsychiatric-and-illicit-drugs-in-wastewater-and-river-waters-from-a-community-in-the-midwestern-united-states
#5
Allie J Skees, Katelyn S Foppe, Bommanna Loganathan, Bikram Subedi
In this study, residues of the neuropsychiatric and illicit drugs including stimulants, opioids, hallucinogens, antischizophrenics, sedatives, and antidepressants were determined in influent and effluent samples from a small wastewater treatment plant, a receiving creek, and river waters in the Four Rivers region of the Midwestern United States. Nineteen neuropsychiatric drugs, eight illicit drugs, and three metabolites of illicit drugs were detected and quantitated in the water samples using HPLC-MS/MS. Residual concentrations of the drugs varied from below the detection limit to sub-μg/L levels...
August 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29724076/greening-reversed-phase-liquid-chromatography-methods-using-alternative-solvents-for-pharmaceutical-analysis
#6
REVIEW
Moussa Yabré, Ludivine Ferey, Issa Touridomon Somé, Karen Gaudin
The greening of analytical methods has gained increasing interest in the field of pharmaceutical analysis to reduce environmental impacts and improve the health safety of analysts. Reversed-phase high-performance liquid chromatography (RP-HPLC) is the most widely used analytical technique involved in pharmaceutical drug development and manufacturing, such as the quality control of bulk drugs and pharmaceutical formulations, as well as the analysis of drugs in biological samples. However, RP-HPLC methods commonly use large amounts of organic solvents and generate high quantities of waste to be disposed, leading to some issues in terms of ecological impact and operator safety...
May 2, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29718405/structure-and-hydrodynamics-of-a-dna-g-quadruplex-with-a-cytosine-bulge
#7
Markus Meier, Aniel Moya-Torres, Natalie J Krahn, Matthew D McDougall, George L Orriss, Ewan K S McRae, Evan P Booy, Kevin McEleney, Trushar R Patel, Sean A McKenna, Jörg Stetefeld
The identification of four-stranded G-quadruplexes (G4s) has highlighted the fact that DNA has additional spatial organisations at its disposal other than double-stranded helices. Recently, it became clear that the formation of G4s is not limited to the traditional G3+NL1G3+NL2G3+NL3G3+ sequence motif. Instead, the G3 triplets can be interrupted by deoxythymidylate (DNA) or uridylate (RNA) where the base forms a bulge that loops out from the G-quadruplex core. Here, we report the first high-resolution X-ray structure of a unique unimolecular DNA G4 with a cytosine bulge...
May 1, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29706893/determinants-of-isoform-specific-gating-kinetics-of-herg1-channel-combined-experimental-and-simulation-study
#8
Laura L Perissinotti, Pablo M De Biase, Jiqing Guo, Pei-Chi Yang, Miranda C Lee, Colleen E Clancy, Henry J Duff, Sergei Y Noskov
IKr is the rapidly activating component of the delayed rectifier potassium current, the ion current largely responsible for the repolarization of the cardiac action potential. Inherited forms of long QT syndrome (LQTS) (Lees-Miller et al., 1997) in humans are linked to functional modifications in the Kv11.1 (hERG) ion channel and potentially life threatening arrhythmias. There is little doubt now that hERG-related component of IKr in the heart depends on the tetrameric (homo- or hetero-) channels formed by two alternatively processed isoforms of hERG, termed hERG1a and hERG1b...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29697505/device-related-error-in-patient-controlled-analgesia-analysis-of-82-698-patients-in-a-tertiary-hospital
#9
Hyo-Jung Son, Sung-Hoon Kim, Jeong-Ok Ryu, Mi-Ra Kang, Myeong-Hee Kim, Jeong-Hun Suh, Jai-Hyun Hwang
BACKGROUND: Patient-controlled analgesia (PCA) is one of the most popular and effective methods for managing postoperative pain. Various types of continuous infusion pumps are available for the safe and accurate administration of analgesic drugs. Here we report the causes and clinical outcomes of device-related errors in PCA. METHODS: Clinical records from January 1, 2011 to December 31, 2014 were collected by acute pain service team nurses in a 2715-bed tertiary hospital...
April 23, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29693650/a-randomized-trial-to-study-the-comparative-efficacy-of-phenylbutyrate-and-benzoate-on-nitrogen-excretion-and-ureagenesis-in-healthy-volunteers
#10
Sandesh C S Nagamani, Umang Agarwal, Allison Tam, Mahshid Azamian, Ann McMeans, Inka C Didelija, Mahmoud A Mohammad, Juan C Marini
PurposeBenzoate and phenylbutyrate are widely used in the treatment of urea cycle disorders, but detailed studies on pharmacokinetics and comparative efficacy on nitrogen excretion are lacking.MethodsWe conducted a randomized, three-arm, crossover trial in healthy volunteers to study pharmacokinetics and comparative efficacy of phenylbutyrate (NaPB; 7.15 g•m-2 BSA•day-1 ), benzoate (NaBz; 5.5 g•m-2 BSA•day-1 ), and a combination of two medications (MIX arm; 3.575 g NaPB and 2.75 g NaBz•m-2 BSA•day-1 ) on nitrogen excretion...
October 12, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29692605/preferences-and-attitudes-of-older-adults-of-bialystok-poland-toward-the-use-of-over-the-counter-drugs
#11
Mateusz Cybulski, Lukasz Cybulski, Elzbieta Krajewska-Kulak, Magda Orzechowska, Urszula Cwalina
Purpose: The aim of the study was to assess preferences and attitudes toward the use of over-the-counter (OTC) drugs among residents of Bialystok aged 60 or older. Patients and methods: The study included 170 people, inhabitants of Bialystok aged over 60: 85 students of the University of a Healthy Senior and the University of Psychogeriatric Prophylaxis, and 85 students of the University of the Third Age in Bialystok. The study made use of a diagnostic survey conducted via a questionnaire prepared by the authors...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29682272/maintenance-of-fish-health-in-aquaculture-review-of-epidemiological-approaches-for-prevention-and-control-of-infectious-disease-of-fish
#12
REVIEW
Ayalew Assefa, Fufa Abunna
Aquaculture is rapidly growing part of agriculture worldwide. It makes up around 44 percent of total fish production globally. This increased growth of production is achieved despite facing many challenges in the aquaculture environment. Among production limiting challenges, the infectious disease takes the lion share by causing multibillion-dollar loss annually. To reduce the impact of the fish disease, it is necessary to address health constraints based on scientifically proven and recommended ways. This review aims at pointing out some of the best approaches to prevention and control of infectious disease in aquaculture...
2018: Veterinary Medicine International
https://www.readbyqxmd.com/read/29680607/one-step-sonochemical-synthesis-of-1d-%C3%AE-stannous-tungstate-nanorods-an-efficient-and-excellent-electrocatalyst-for-the-selective-electrochemical-detection-of-antipsychotic-drug-chlorpromazine
#13
Thangavelu Kokulnathan, Jeyaraj Vinoth Kumar, Shen-Ming Chen, Raj Karthik, Arumugam Elangovan, Velluchamy Muthuraj
In the modern world, the contamination of ecosystem by human and veterinary pharmaceutical drugs through the metabolic excretion, improper disposal/industrial waste has been subjected to a hot issue. Therefore, exploitation of exclusive structured material and reliable technique is a necessary task to the precise detection of drugs. With this regards, we made an effort for the fabrication of novel one-dimensional (1D) stannous tungstate nanorods (β-SnW NRs) via simple sonochemical approach and used as an electrochemical sensor for the detection of antipsychotic drug chlorpromazine (CPZ) for the first time...
June 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29673140/euthanasia-of-cattle-practical-considerations-and-application
#14
REVIEW
Jan Keith Shearer
Acceptable methods for the euthanasia of cattle include overdose of an anesthetic, gunshot and captive bolt. The use of anesthetics for euthanasia is costly and complicates carcass disposal. These issues can be avoided by use of a physical method such as gunshot or captive bolt; however, each requires that certain conditions be met to assure an immediate loss of consciousness and death. For example, the caliber of firearm and type of bullet are important considerations when gunshot is used. When captive bolt is used, a penetrating captive bolt loaded with the appropriate powder charge and accompanied by a follow up (adjunctive) step to assure death are required...
April 17, 2018: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/29672874/review-article-novel-oral-targeted-therapies-in-inflammatory-bowel-disease
#15
REVIEW
J R White, F Phillips, T Monaghan, W Fateen, S Samuel, S Ghosh, G W Moran
BACKGROUND: There is a great unmet clinical need for efficacious, tolerable, economical and orally administrated drugs for the treatment of inflammatory bowel disease (IBD). New therapeutic avenues have become possible including the development of medications that target specific genetic pathways found to be relevant in other immune mediated diseases. AIMS: To provide an overview of recent clinical trials for new generation oral targeted medications that may have a future role in IBD management...
April 19, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29671346/insulin-resistance-is-associated-with-larger-thyroid-volume-in-adults-with-type-1-diabetes-independently-from-presence-of-thyroid-autoimmunity
#16
Anita Rogowicz-Frontczak, Stanislaw Pilacinski, Anna Teresa Chwialkowska, Dariusz Naskret, Dorota Zozulinska-Ziolkiewicz
To investigate the effect of insulin resistance (IR) on thyroid function, thyroid autoimmunity (AIT) and thyroid volume in type 1 diabetes (T1DM). 100 consecutive patients with T1DM aged 29 (±6) years with diabetes duration 13 (±6) years were included. Exclusion criteria were: history of thyroid disease, current treatment with L-thyroxin or anti-thyroid drugs. Evaluation of thyroid stimulating hormone (TSH), free thyroid hormones and anti-thyroid antibodies was performed. Thyroid volume was measured by ultrasonography...
April 19, 2018: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29665788/medical-expenses-of-urban-chinese-patients-with-stomach-cancer-during-2002-2011-a-hospital-based-multicenter-retrospective-study
#17
Xiao-Jie Sun, Ju-Fang Shi, Lan-Wei Guo, Hui-Yao Huang, Neng-Liang Yao, Ji-Yong Gong, Ya-Wen Sun, Guo-Xiang Liu, A-Yan Mao, Xian-Zhen Liao, Ya-Na Bai, Jian-Song Ren, Xin-Yu Zhu, Jin-Yi Zhou, Ling Mai, Bing-Bing Song, Yu-Qin Liu, Lin Zhu, Ling-Bin Du, Qi Zhou, Xiao-Jing Xing, Pei-An Lou, Xiao-Hua Sun, Xiao Qi, Yuanzheng Wang, Rong Cao, Ying Ren, Li Lan, Kai Zhang, Jie He, Jia-Lin Wang, Min Dai
BACKGROUND: In China, stomach cancer is the third most common cancer and the third leading cause of cancer death. Few studies have examined Chinese stomach cancer patients' medical expenses and their associated trends. The Cancer Screening Program in Urban China (CanSPUC) is a Major Public Health Project funded by the central government. Through this project, we have extracted patients' medical expenses from hospital billing data to examine the costs of the first course treatments (which refers to 2 months before and 10 months after the date of cancer diagnosis) in Chinese patients with stomach cancer and the associated trends...
April 17, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29664613/advanced-materials-and-devices-for-bioresorbable-electronics
#18
Seung-Kyun Kang, Jahyun Koo, Yoon Kyeung Lee, John A Rogers
Recent advances in materials chemistry establish the foundations for unusual classes of electronic systems, characterized by their ability to fully or partially dissolve, disintegrate, or otherwise physically or chemically decompose in a controlled fashion after some defined period of stable operation. Such types of "transient" technologies may enable consumer gadgets that minimize waste streams associated with disposal, implantable sensors that disappear harmlessly in the body, and hardware-secure platforms that prevent unwanted recovery of sensitive data...
April 17, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29661997/implementation-of-safe-by-design-for-nanomaterial-development-and-safe-innovation-why-we-need-a-comprehensive-approach
#19
Annette Kraegeloh, Blanca Suarez-Merino, Teun Sluijters, Christian Micheletti
Manufactured nanomaterials (MNMs) are regarded as key components of innovations in various fields with high potential impact (e.g., energy generation and storage, electronics, photonics, diagnostics, theranostics, or drug delivery agents). Widespread use of MNMs raises concerns about their safety for humans and the environment, possibly limiting the impact of the nanotechnology-based innovation. The development of safe MNMs and nanoproducts has to result in a safe as well as functional material or product. Its safe use, and disposal at the end of its life cycle must be taken into account too...
April 14, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29661159/active-dna-end-processing-in-micronuclei-of-ovarian-cancer-cells
#20
Zizhi Tang, Juan Yang, Xin Wang, Ming Zeng, Jing Wang, Ao Wang, Mingcai Zhao, Liandi Guo, Cong Liu, Dehua Li, Jie Chen
BACKGROUND: Ovarian cancer is one of the most deadly gynecological malignancies and inclined to recurrence and drug resistance. Previous studies showed that the tumorigenesis of ovarian cancers and their major histotypes are associated with genomic instability caused by defined sets of pathogenic mutations. In contrast, the mechanism that influences the development of drug resistance and disease recurrence is not well elucidated. Solid tumors are prone to chromosomal instability (CIN) and micronuclei formation (MN)...
April 16, 2018: BMC Cancer
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