Daria Jaworska-Krych, Monika Gosecka, Mateusz Gosecki, Malgorzata Urbaniak, Katarzyna Dzitko, Anita Ciesielska, Ewelina Wielgus, Slawomir Kadlubowski, Marcin Kozanecki
The poor solubility of clotrimazole in the aqueous medium and the uncontrolled removal of the drug-loaded suppository content limit its effectiveness in the treatment of vulvovaginal candidiasis. We present here the aqueous formulations of clotrimazole in the form of non-Newtonian structured fluids, i.e. , Bingham plastic or pseudoplastic fluids constructed of hyperbranched polyglycidol, HbPGL, with a hydrophobized core with aryl groups such as phenyl or biphenyl. The amphiphilic constructs were obtained by the modification of linear units containing monohydroxyl groups with benzoyl chloride, phenyl isocyanate, and biphenyl isocyanate, while the terminal 1,2-diol groups in the shell were protected during the modification step, followed by their deprotection...
April 5, 2024: ACS Applied Materials & Interfaces