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Muhammad Z Khan, Muhammad Waqas, Hadia Shah, Sona Franklin, Ayesha Jamil
Carmustine is an intravenous alkylating agent that inhibits DNA synthesis and protein synthesis by forming cross-links in DNA and RNA and ultimately causing cell death. We report a rare case of Takotsubo cardiomyopathy that is thought to be related to carmustine, where the patient presented with chest pain, and ST depression within 12 hours of carmustine therapy. Workup, including echocardiography, showed global hypokinesis of the left ventricle with regional variations; mid and apical anterior septum and apex were akinetic with left ventricular ejection fraction (EF) of 30%...
December 2023: Curēus
#22
JOURNAL ARTICLE
Michael D Nailor, Kellie J Goodlet, Omar Gonzalez, J Tyler Haller
BACKGROUND: Intrathecal administration of amphotericin B represents an important adjunctive therapy for management of severe fungal meningitis. Intrathecal preparations have traditionally used amphotericin B deoxycholate. Liposomal amphotericin B is an alternative formulation with good clinical outcomes as systemic therapy, but scant data exist investigating intrathecal use. OBJECTIVE: The aim of this exploratory study was to evaluate outcomes following intrathecal administration of liposomal amphotericin B for treatment of severe fungal meningitis...
January 25, 2024: CNS Drugs
#23
REVIEW
Nidhi Mehrotra, Padmavati Manchikanti
The coronavirus disease 2019 (COVID-19) pandemic highlighted the world's level of preparedness in managing public health emergencies (PHEs). It revealed the critical need for timely medical therapeutics, especially vaccines. To expedite response, many nations, including India, adopted emergency approval mechanisms and offered new ways of review, such as the rolling review along with the accelerated review procedure. This response resulted in reallocating internal resources and adopting new policies and measures, such as integrating digital technology with regulatory submissions and flexibility in statistical approaches...
January 24, 2024: Pharmaceutical Medicine
#24
JOURNAL ARTICLE
Wei Wu, Yuhan Shi, Jingya Liu, Xiaoyu Liu, Hao Liu, Tao Wang, Guoqi Zhang, Zhihong Xu
Household storage of pharmaceuticals to extract raw materials synthesized from carbon points facilitates the utilization of solid waste resources. A novel ratiometric fluorescence sensing technique was developed to ascertain the presence of horseradish peroxidase (HRP) in fruits and vegetables. The method employed a fluorescent probe, synthesized from expired amoxicillin (referred to as carbon dots, or A-CDs), serving as a reference fluorophore. Additionally, 2,3-diaminophenazine (DAP) was utilized as a specific response signal...
January 22, 2024: Mikrochimica Acta
#25
JOURNAL ARTICLE
Maria Tarsia, Antonio Vitale, Carla Gaggiano, Jurgen Sota, Anna Maselli, Chiara Bellantonio, Silvana Guerriero, Rosanna Dammacco, Francesco La Torre, Gaafar Ragab, Mohamed Tharwat Hegazy, Alex Fonollosa, Maria Pia Paroli, Emanuela Del Giudice, Maria Cristina Maggio, Marco Cattalini, Lampros Fotis, Giovanni Conti, Angela Mauro, Adele Civino, Federico Diomeda, Alejandra de-la-Torre, Carlos Cifuentes-González, Samar Tharwat, José Hernández-Rodríguez, Verónica Gómez-Caverzaschi, Laura Pelegrín, Kalpana Babu, Vishali Gupta, Francesca Minoia, Piero Ruscitti, Stefania Costi, Luciana Breda, Saverio La Bella, Alessandro Conforti, Maria Antonietta Mazzei, Ester Carreño, Rana Hussein Amin, Salvatore Grosso, Bruno Frediani, Gian Marco Tosi, Alberto Balistreri, Luca Cantarini, Claudia Fabiani
INTRODUCTION: Since many biological drug patents have expired, biosimilar agents (BIOs) have been developed; however, there are still some reservations in their use, especially in childhood. The aim of the current study is to evaluate the efficacy and safety of tumor necrosis factor (TNF) inhibitors BIOs as treatment for pediatric non-infectious uveitis (NIU). METHODS: Data from pediatric patients with NIU treated with TNF inhibitors BIOs were drawn from the international AutoInflammatory Disease Alliance (AIDA) registries dedicated to uveitis and Behçet's disease...
January 11, 2024: Ophthalmology and Therapy
#26
JOURNAL ARTICLE
Nanjiba Nawaz, Tyler Mistretta, Christian Karime, Jason Lewis, Emily Wolf
Niacin, an important component of a balanced diet, is central to lipid metabolism. Occasionally used to treat hyperlipidemia, niacin is widely available without a prescription, making its use often unknown to treating physicians. Severe hepatotoxicity has been reported with niacin use. In the following report, we describe a case of hospitalization for acute decompensated cirrhosis with cholestatic morphology in a patient taking self-initiated large quantities of extended-release niacin. Despite medical management and support, the patient unfortunately expired on day 16 of hospitalization...
2024: Journal of Investigative Medicine High Impact Case Reports
#27
JOURNAL ARTICLE
Richard T Rogers, Ha Tran, Starlie C Belnap, Amy K Starosciak
Introduction Individuals using cocaine, methamphetamines, cannabis, and other mood-altering drugs (MADs) have been reported to have greater stroke risk when compared to individuals who do not use these drugs. Yet, the impact that MAD use has on stroke outcomes has not been adequately explored, with existing research not agreeing on the extent to which the use of these drugs influences stroke outcomes. This study aimed to determine the impact that the use of common MADs has on stroke outcome factors such as length of stay (LOS), discharge modified Rankin Scale (mRS), and discharge disposition...
December 2023: Curēus
#28
JOURNAL ARTICLE
Ghyli Kirshner, Peter Makai, Chiara Brouns, Lonneke Timmers, Ron Kemp
In this paper, we explore dynamic market share and public healthcare costs of trastuzumab's evergreening (subcutaneous) variant during introduction of trastuzumab's competitive biosimilar variants in the Netherlands. We used a time series design to assess dynamic market share of trastuzumab's evergreening variant after introducing trastuzumab's biosimilar variants, focusing on the number of treatments and patients. The public healthcare costs of this evergreening strategy were estimated using administrative claims data...
January 8, 2024: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
#29
JOURNAL ARTICLE
Geo-Seong Park, Jung-Soo Park
INTRODUCTION: Patients with cerebral arteriovenous malformation (AVM) have a lifetime risk of hemorrhagic stroke. Although identified asymptomatic cases can be monitored with imaging follow-up, treatment is considered in cases of AVM rupture or hemodynamic instability. PATIENT CONCERNS: A 43-year-old man who had been taking antihypertensive drugs for the past 5 years visited our hospital 3 days after the abrupt onset of headache. The patient also complained of progressive ptosis in the left eye...
January 5, 2024: Medicine (Baltimore)
#30
JOURNAL ARTICLE
Pengfei Li, Ping Du, Jun Peng, Zhixia Zhao, Huiling Li, Weiyue Yu, Shumin Wang, Lihong Liu
BACKGROUND AND OBJECTIVE: Definity is an ultrasound contrast agent consisting of phospholipids-encapsulated perfluoropropane (PFP), also known as perflutren, microspheres, which is initially designed to enhance echocardiographic ultrasound images. With no pharmacologic action, Definity can increase the backscatter of ultrasound resulting enhanced ultrasound signals. The objective of this study was to determine the pharmacokinetics (PKs), Pharmacodynamics (PDs) and safety of Definity in healthy male and female Chinese volunteers...
January 2, 2024: BMC Pharmacology & Toxicology
#31
JOURNAL ARTICLE
Parvaiz A Koul, Hyder Mir, Tajamul H Shah, Rafi A Jan, Sanaullah Shah, Syed Mudassir Qadri, Umar Hafiz Khan, Nazia Mehfooz, Farhana Bagdadi
Antiviral combinations have been proposed as treatment for influenza in order to increase the antiviral activity by action at different sites of action as well as obviate the emergence of drug resistance to the commonly used antiviral agents like oseltamivir. Nitazoxanide has been found to exhibit anti-influenza viral activity with clinical benefit in a previous study. We recruited 242 cases of SARI, among whon 67 were confirmed to have influenza viral infection. In a randomized blinded fashion, 34 patients received a combination of nitazoxanide and oseltamivir whereas 33 cases received oseltamivir alone...
January 1, 2024: Lung India: Official Organ of Indian Chest Society
#32
JOURNAL ARTICLE
Muhammad Majid Aziz, Amany Alboghdadly, Muhammad Fawad Rasool, Marwa S Shaalan, Hind Khalid Goresh, Muath Fahmi Najjar, Samar Zuhair Alshawwa
OBJECTIVES: This study aimed to assess compliance with legal requirements, safe medication storage and staffing standards in community pharmacies in Punjab, Pakistan. METHOD: We conducted a three-step cross-sectional study using observations, questionnaires and face-to-face interviews in 544 systematically-selected community pharmacies. We used descriptive statistic and one-way ANOVA to assess the data. RESULTS: Only 23 (4.2 %) pharmacies had accurate area and only 3...
December 2023: Heliyon
#33
JOURNAL ARTICLE
Jenna Salter, Van Tran, David Bastawrous, Andrew Nuibe
OBJECTIVE: As broader spectrum antibiotics have been associated with adverse effects, our study evaluated whether the frequency of culture-positive late-onset sepsis (LOS) and multidrug resistant (MDR) infections were increased with the use of ceftazidime as compared with cefotaxime in the neonatal intensive care unit (NICU). METHODS: This was a multihospital, retrospective chart review of patients who received at least 24 hours of ceftazidime or cefotaxime in the NICU between December 1, 2012 and August 31, 2021...
2023: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
#34
JOURNAL ARTICLE
Samuel H Zuvekas
BACKGROUND: The COVID-19 pandemic has been widely reported to have increased symptoms of anxiety, depression, and other mental health issues. It may also have significantly disrupted continuity of treatment for existing patients and made access for those newly seeking care more difficult at a time when treatment needs are higher. AIMS OF THE STUDY: This study seeks to examine the impact of the COVID-19 pandemic on mental health status and mental health treatment among adults residing in the U...
December 1, 2023: Journal of Mental Health Policy and Economics
#35
JOURNAL ARTICLE
Jerry Toe, Edidiong Orok, Patrick Erah
BACKGROUND: Expansion of pharmaceutical industries and improved availability of pharmaceuticals across the world have contributed to an increase in drug usage and accumulation in homes. Improper disposal of expired and unused medications has several consequences such as environmental pollution, and childhood poisoning. OBJECTIVES: The aim of the study was to assess the knowledge on disposal as well as disposal practices of unused and expired household medicines in the Parker Corner Road Community in Brewerville, Liberia...
December 2023: Explor Res Clin Soc Pharm
#36
Francis Atemnkeng, Fatima Aguilar, Sanjeev Gupta, Savneek Chugh, Michael Klein
Enfortumab vedotin is a novel breakthrough therapy that received accelerated US Food and Drug Administration approval in 2019 for the treatment of metastatic urothelial carcinoma in patients who have failed other lines of treatment. The characteristics of its adverse effects are not well understood. Diabetic ketoacidosis has been reported in 2 postmarketing reports presented as abstracts at the 2020 American Thoracic Society Conference and the 2021 American Society of Nephrology Conference. Both cases progressed rapidly and expired in <3 days...
December 2023: Kidney medicine
#37
JOURNAL ARTICLE
Mohit Chowdhry, Ankita Sharma, Soma Agrawal, Rohit Vohra, Karunesh Kumar, Neerav Goyal, Arun Kumar V, Nameet Jerath, Smita Malhotra, Anupam Sibal, Manoj Mishra
BACKGROUND: Acute liver failure in the pediatric population is often accompanied by deranged metabolism, severe encephalopathy and coagulopathy. A liver transplant is the most viable option for the management of such patients. Therapeutic plasma exchange (TPE) is helpful in improving the liver biochemistry profile, thereby, increasing their likelihood of undergoing a liver transplant METHOD: The study was conducted over a period of 3 years (January 2018 to December 2021). Indications mainly consisted of ALF with hepatic encephalopathy, worsening liver parameters in spite of medical management, and candidacy for undergoing a liver transplant...
October 21, 2023: Transfusion and Apheresis Science
#38
JOURNAL ARTICLE
Yunlei Zang, Guibin Liu, Wenyu Ji, Yongfei Li, Gang Chen
At present, the treatment of expired medicines mainly involves burning, which means waste of resources and carbon dioxide emissions, and it does not comply with the concept of resource recycling. In this study, in order to explore the resource utilization pathways of expired medicines, progesterone drugs were evaluated as crude oil flow improvers as an example. The results shows that progesterone injection (PI) and progesterone capsule (PC) both act as viscosity reducer and pour point depressant in different crude oil, and 500 ppm PI and 300 ppm PC are the best dosage respectively...
November 19, 2023: Journal of Environmental Management
#39
JOURNAL ARTICLE
Anders Olsen, Reed F Beall, Ryan P Knox, Sean S Tu, Aaron S Kesselheim, William B Feldman
BACKGROUND: Insulin is the primary treatment for type 1 and some type 2 diabetes but remains costly in the United States, even though it was discovered more than a century ago. High prices can lead to nonadherence and are often sustained by patents and regulatory exclusivities that limit competition on brand-name products. We sought to examine how manufacturers have used patents and regulatory exclusivities on insulin products approved from 1986 to 2019 to extend periods of market exclusivity...
November 2023: PLoS Medicine
#40
Ali Tariq Alvi, Sachin George Mathew, Murali Shankar
Drug-induced liver failure is a relatively uncommon condition with a vast spectrum of clinical manifestations, and it is a leading cause of acute hepatic failure in the United States. We describe the first case of fulminant hepatic failure induced by chemotherapeutic drug daratumumab, a common FDA-approved agent. A 77-year-old male, with a history of multiple myeloma, was admitted for left lower extremity cellulitis, two weeks after receiving his first intravenous infusion of daratumumab. He developed fulminant hepatic failure in the hospital a few days later...
October 2023: Curēus
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