keyword
MENU ▼
Read by QxMD icon Read
search

Expired drugs

keyword
https://www.readbyqxmd.com/read/28177206/propofol-sedation-reduces-diaphragm-activity-in-spontaneously-breathing-patients-ultrasound-assessment
#1
Monica Rocco, Luigi Maggi, Giorgio Ranieri, Giovanni Ferrari, Cesare Gregoretti, Giorgio Conti, Roberto A DE Blasi
BACKGROUND: The diaphragm is the most important respiratory muscle in humans, and the close relationship between inspired volume and diaphragmatic movement in normal subjects has led to investigations into diaphragmatic activity using ultrasound, during spontaneous breathing and sedative drug infusion. METHODS: A total of 36 consecutive patients undergoing diagnostic procedures under deep propofol sedation were studied. Ultrasound measurements included the following: diaphragmatic thickening end-inspiration (TEI) and end-expiration (TEE)...
February 8, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28156620/usage-of-oregon-s-death-with-dignity-act-dwda
#2
Michael Leo LeBlanc, Dawn L Hershman, Lee M Ellis, Frank L Meyskens
: 44 Background: In 1997, OR enacted a voter initiative allowing terminally ill residents to self-administer physician-prescribed medication to end their lives. Statute requires prescriptions written for lethal medications be reported; the state also collects demographic and intended use data. We wished to to evaluate and report participation trends. METHODS: OR's Public Health Division gathers compliance forms from prescribing/consulting physicians, pharmacists, and psychiatrists, prescribing physician follow-up forms, and death certificates...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28144686/-new-technical-developments-for-inhaled-sedation
#3
A Meiser, H Bomberg, T Volk, H V Groesdonk
The circle system has been in use for more than 100 years, whereas the first clinical application of an anaesthetic reflector was reported just 15 years ago. In the circle system, all breathing gas is rebreathed after carbon dioxide absorption. A reflector, on the other hand, with the breathing gas flowing to and fro, specifically retains the anaesthetic during expiration and resupplies it during the next inspiration. A high reflection efficiency (number of molecules resupplied/number of molecules exhaled, RE 80-90%) decreases consumption...
January 31, 2017: Der Anaesthesist
https://www.readbyqxmd.com/read/28142147/history-of-erythropoiesis-stimulating-agents-the-development-of-biosimilars-and-the-future-of-anemia-treatment-in-nephrology
#4
Kamyar Kalantar-Zadeh
BACKGROUND: Exogenous replacement of erythropoietin (EPO) by recombinant human EPO has been considered a standard of care for the treatment of anemia in patients with chronic kidney disease for more than 20 years. Genetically engineered biologic proteins derived from human, animal, or microorganism sources are a major area of growth in modern medical care, accounting for one-third of new drug approvals in the past decade. Despite benefit to patients, the use of biologics comes at a significant cost, representing one of the fastest growing segments of strained healthcare budgets around the world...
February 1, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28127349/disseminated-strongyloidiasis-in-an-immunodeficient-patient-pemphigus-vulgaris-due-to-corticosteroid-therapy-a-case-report
#5
Mohsen Najjari, Mohammad Ebrahimipour, Amir Kaheh, Mohammadreza Karimazar
Strongyloidiasis is a frequent misdiagnosed parasitic infection in the world that caused by Strongyloides stercoralis. In Iran, the disease is predominantly reported from warm and humid climate provinces. The patient was a 54-yr-old man, originated from Khuzestan Province with a history of pemphigus and diabetes that was treated with high-dose of corticosteroid drugs before admission in a non-private hospital in Shiraz, Iran in 2014. After different primary diagnosis and administrating of several drugs, endoscopy and histopatholgical biopsy revealed a massive S...
July 2016: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28127193/biosimilars-in-inflammatory-bowel-disease-a-review-of-post-marketing-experience
#6
REVIEW
Simona Deiana, Tommaso Gabbani, Vito Annese
Biologic compounds are obtained from living organisms or cell cultures by means of biotechnology methods. A similar biologic drug, commonly called biosimilar, is a product copied by a native approved biologic drug whose license has expired. Biosimilar drugs usually are marketed at a lower price and provide important financial savings for public healthcare systems. Some differences between biosimilars and original biologic drugs might exist but they are acceptable if they fall within defined "boundaries of tolerance": differences in some features between the two molecules are considered important only if clinical relevant...
January 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28118050/administration-of-biosimilar-insulin-analogs-role-of-devices
#7
Lutz Heinemann, Ingo Fritz, Hootan Khatami, Steven V Edelman
With the expiration of patent protection for several originator insulin analog molecules, the availability of insulin analog copies is set to increase. Many regulatory authorities have developed, and continue to refine, guidelines for the approval of biosimilar insulin analogs. Aspects such as the structure, pharmacokinetics and pharmacodynamics, efficacy, safety, and immunogenicity of biosimilar insulin analogs are extensively addressed in these guidelines, but how the biosimilar insulin analog is administered to people with diabetes is not usually a topic...
February 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28116676/scientific-and-regulatory-considerations-for-generic-complex-drug-products-containing-nanomaterials
#8
Nan Zheng, Dajun D Sun, Peng Zou, Wenlei Jiang
In the past few decades, the development of medicine at the nanoscale has been applied to oral and parenteral dosage forms in a wide range of therapeutic areas to enhance drug delivery and reduce toxicity. An obvious response to these benefits is reflected in higher market shares of complex drug products containing nanomaterials than that of conventional formulations containing the same active ingredient. The surging market interest has encouraged the pharmaceutical industry to develop cost-effective generic versions of complex drug products based on nanotechnology when the associated patent and exclusivity on the reference products have expired...
January 23, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28112087/tackling-the-climate-targets-set-by-the-paris-agreement-cop-21-green-leadership-empowers-public-hospitals-to-overcome-obstacles-and-challenges-in-a-resource-constrained-environment
#9
E Weimann, B Patel
The healthcare sector itself contributes to climate change, the creation of hazardous waste, use of toxic metals such as mercury, and water and air pollution. To mitigate the effect of healthcare provision on the deteriorating environment and avoid creating further challenges for already burdened health systems, Global Green Hospitals was formed as a global network. Groote Schuur Hospital (GSH), as the leading academic hospital in Africa, joined the network in 2014. Since then, several projects have been initiated to reduce the amount of general waste, energy consumption and food waste, and create an environmentally friendlier and more sustainable hospital in a resource-constrained public healthcare setting...
December 21, 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28068848/the-safety-of-emerging-biosimilar-drugs-for-the-treatment-of-rheumatoid-arthritis
#10
J Braun, J Kay
Biological disease-modifying anti-rheumatic drugs (bDMARDs), often administered in combination with methotrexate, target specific inflammatory mediators and have transformed the treatment of rheumatic diseases, especially rheumatoid arthritis (RA) but also the spondyloarthritides. However, the high cost of these drugs in many countries restricts patient access. As many bDMARDs have reached or are near to patent expiration, numerous biosimilar drugs are in development and some have already been approved. Biosimilars are generally priced lower than their reference products (RPs), or bio-originators, and as prices come down it is hoped that patient access to these drugs will increase, making the safety of these drugs an area of major interest...
March 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28068518/impact-of-space-environment-on-stability-of-medicines-challenges-and-prospects
#11
REVIEW
Priti Mehta, Dhara Bhayani
To upkeep health of astronauts in a unique, isolated, and extreme environment of space is the primary goal for a successful space mission, hence, safe and efficacious medications are essential for the wellness of astronauts. Space medication has been challenged with problems related to efficacy. Along with altered physiology, one of the possible reasons could be instability of space medications in the presence of harsh spaceflight environmental conditions. Altered physical and chemical stability can result in reduced potency which can result in reduced efficacy...
March 20, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28066115/comparison-of-the-knowledge-attitude-and-practices-of-doctors-nurses-and-pharmacists-regarding-the-use-of-expired-and-disposal-of-unused-medicines-in-delhi
#12
Kriti Bhayana, Harmeet Singh Rehan, Tarun Arora
OBJECTIVES: The use of out-of-date medicines and improper disposal of pharmaceutical products harm consumers and environment. To limit pharmaceutical load on the environment, it is important that healthcare professionals (HCPs) are aware of and have good practices toward their disposal. MATERIALS AND METHODS: A pretested instructor administered questionnaire containing 21 questions was used to assess knowledge, attitude, and practices (KAP) of 300 HCPs toward use and disposal of unwanted/expired medicines...
November 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28034518/sex-effect-on-average-bioequivalence
#13
Manuel Ibarra, Marta Vázquez, Pietro Fagiolino
PURPOSE: Generic formulations are by far the most prescribed drugs. This scenario is highly beneficial for society because medication expenses are significantly reduced after expiration of the exclusivity period conceded to the branded name drug. Correspondingly, these formulations must be adequately evaluated to avoid drug inefficacy and toxicity in the overall patient population. Bioequivalence studies are the only in vivo evaluation that a generic drug must overcome to reach the market...
January 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28033700/brucellosis-with-multi-organ-involvement-in-a-patient-with-history-of-composite-aortic-graft-and-hepatitis-b
#14
Seyed Ali Dehghan Manshadi, Omid Rezahosseini, Zahra Abdi Liaei
The brucellosis with multi-organ involvement in a patient with a history of the composite aortic graft (Bentall procedure) and Hepatitis B infection is rare. A 35-year-old man presented to us with fever and loss of consciousness. Four years ago, he was IDU and underwent cardiac surgery because of endocarditis. Recently lumbar spondylodiscitis was diagnosed. The Wright (1/320) and Coombs Wright tests (1/640) were positive. After CNS imaging, lumbar puncture was done. The CSF pleocytosis was lymphocyte dominant...
November 2016: Acta Medica Iranica
https://www.readbyqxmd.com/read/28012020/product-safety-spillovers-and-market-viability-for-biologic-drugs
#15
John Romley, Tiffany Shih
When a pharmaceutical manufacturer experiences a safety problem, negative impacts on profitability can spread to its competitors. Reduced consumer confidence, product recalls, and litigation are limited to the responsible manufacturer only if that manufacturer can be clearly linked to the safety problem. We analyze the impact of "accountability" for safety problems on manufacturer entry decisions and investments to mitigate risk. Consistent with prior research, we find investment levels increase with accountability in a duopoly market, and that accountability can thus enhance market viability and improve consumer welfare...
December 23, 2016: Int J Health Econ Manag
https://www.readbyqxmd.com/read/27940634/effectiveness-of-medicines-authentication-technology-to-detect-counterfeit-recalled-and-expired-medicines-a-two-stage-quantitative-secondary-care-study
#16
Bernard Naughton, Lindsey Roberts, Sue Dopson, Stephen Chapman, David Brindley
OBJECTIVES: To identify the authentication and detection rate of serialised medicines using medicines authentication technology. DESIGN AND INTERVENTION: 4192 serialised medicines were entered into a hospital dispensary over two separate 8-week stages in 2015. Medicines were authenticated using secure external database cross-checking, triggered by the scanning of a two-dimensional data matrix with a unit specific 12-digit serial code. 4% of medicines included were preprogrammed with a message to identify the product as either expired, pack recalled, product recalled or counterfeit...
December 9, 2016: BMJ Open
https://www.readbyqxmd.com/read/27922254/comparison-of-two-different-forms-of-sevoflurane-for-anaesthesia-maintenance-and-recovery
#17
Yonca Yanli, Mehtap Ozdemir, Nurten Bakan, Cafer T Yuruk, Ahmet Yildirim, Ali O Cetinkaya
BACKGROUND: Sevoflurane is a commonly used inhalation agent. There are two forms of sevoflurane in Turkey. The aim of this study was to evaluate the effects of original versus generic sevoflurane products on hemodynamics, time to reach 1 MAC level, inspired and expired sevoflurane levels and postoperative recovery profile. METHODS: Seventy patients undergoing general anaesthesia were divided into two groups as Group Sevo or Group Sojo. After intravenous induction of anaesthesia (with the same drugs in both groups), inhalation anaesthetic was started...
December 6, 2016: Minerva Anestesiologica
https://www.readbyqxmd.com/read/27913790/do-cigarette-graphic-warnings-encourage-smokers-to-attend-a-smoking-cessation-programme-a-quasi-experimental-study
#18
Joseph Guydish, Barbara Tajima, Thao Le, Catherine Henderson, Deborah Yip, Valerie Gruber, Wayne Garcia, Kevin L Delucchi
OBJECTIVE: This study assessed whether exposure to cigarette graphic warning labels (GWLs) increased attendance to a smoking cessation programme. METHOD: From 2014 to 2016, alternating cohorts of smokers in 3 residential drug treatment programmes received either GWLs (experimental) or transparent (control) labels placed on their cigarette packs for 30 days. The primary outcome was the proportion of participants who chose to attend a smoking cessation group after the labelling period...
December 2, 2016: Tobacco Control
https://www.readbyqxmd.com/read/27883912/development-of-potential-candidate-reference-materials-for-drugs-in-bottom-sediment-cod-and-herring-tissues
#19
Irena Baranowska, Bogusław Buszewski, Jacek Namieśnik, Piotr Konieczka, Sylwia Magiera, Halina Polkowska-Motrenko, Paweł Kościelniak, Renata Gadzała-Kopciuch, Aneta Woźniakiewicz, Zbigniew Samczyński, Kinga Kochańska, Małgorzata Rutkowska
Regular use of a reference material and participation in a proficiency testing program can improve the reliability of analytical data. This paper presents the preparation of candidate reference materials for the drugs metoprolol, propranolol, carbamazepine, naproxen, and acenocoumarol in freshwater bottom sediment and cod and herring tissues. These reference materials are not available commercially. Drugs (between 7 ng/g and 32 ng/g) were added to the samples, and the spiked samples were freeze-dried, pulverized, sieved, homogenized, bottled, and sterilized by γ-irradiation to prepare the candidate materials...
February 2017: Chemosphere
https://www.readbyqxmd.com/read/27881996/quality-of-drug-stores-storage-practices-regulatory-compliance-in-karachi-pakistan
#20
Syed Shaukat Ali Muttaqi Shah, Baqar Shyum Naqvi, Mashhad Fatima, Asif Khaliq, Abdul Latif Sheikh, Muhammad Baqar
OBJECTIVE: To assess and evaluate the drug storage quality and regulatory compliance among privately operated drug stores of Karachi Pakistan. METHODS: A cross-sectional survey of drug stores located in Karachi was conducted from May to December 2013. A total of 1003 drug stores that were involved in the sales, purchase and dispensing of pharmaceutical products were approached by non-probability purposive sampling technique, and the information was collected using a close ended, structured questionnaire...
September 2016: Pakistan Journal of Medical Sciences Quarterly
keyword
keyword
114982
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"