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https://www.readbyqxmd.com/read/28728086/nanostructured-lipid-systems-modified-with-waste-material-of-propolis-for-wound-healing-design-in-vitro-and-in-vivo-evaluation
#1
Hélen Cássia Rosseto, Lucas de Alcântara Sica de Toledo, Lizziane Maria Belloto de Francisco, Elisabetta Esposito, Yunsook Lim, Giuseppe Valacchi, Rita Cortesi, Marcos Luciano Bruschi
Propolis, a natural compound that can accelerate the wound healing process, is mainly used as ethanolic extract. The extractive solution may also be obtained from the propolis by-product (BP), transforming this waste material into a pharmaceutical active ingredient. Even if propolis does not show toxicity, when used as an extract over harmed skin or mucosa, the present ethanol content may be harmful to the tissue recovering, besides hindering the drug release. This study describes the development of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) as topical propolis delivery systems and the investigation of their in vitro and in vivo activities...
July 10, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28720419/isolation-of-two-ochrobactrum-sp-strains-capable-of-degrading-the-nootropic-drug-piracetam
#2
Marta Woźniak-Karczewska, Monika Čvančarová, Łukasz Chrzanowski, Boris Kolvenbach, Philippe F-X Corvini, Danuta Cichocka
Piracetam (2-oxo-1-pyrrolidine acetamide) is a popular cognitive enhancer, which has recently been detected in waste and drinking water. Nootropic drugs are designed to affect human metabolism and act on the nervous system, but their environmental effects have yet to be the subject of detailed studies. In this report, we present the efficient biodegradation of the cognitive enhancer, piracetam. Two bacterial strains capable of using this compound as the sole carbon source were isolated and later identified as Ochrobactrum anthropi strain MW6 and Ochrobactrum intermedium strain MW7...
July 15, 2017: New Biotechnology
https://www.readbyqxmd.com/read/28709127/chemometrically-assisted-development-and-validation-of-lc-ms-ms-method-for-the-analysis-of-potential-genotoxic-impurities-in-meropenem-active-pharmaceutical-ingredient
#3
Katerina Grigori, Yannis L Loukas, Anđelija Malenović, Vicky Samara, Anastasia Kalaskani, Efi Dimovasili, Magda Kalovidouri, Yannis Dotsikas
A sensitive Liquid Chromatography tandem mass spectrometry (LC-MS/MS) method was developed and validated for the quantitative analysis of three potential genotoxic impurities (318BP, M9, S5) in meropenem Active Pharmaceutical Ingredient (API). Due to the requirement for LOD values in ppb range, a high concentration of meropenem API (30mg/mL) had to be injected. Therefore, efficient determination of meropenem from its impurities became a critical aim of this study, in order to divert meropenem to waste, via a switching valve...
June 29, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28701021/apple-pomace-as-potential-source-of-natural-active-compounds
#4
Katharina Waldbauer, Ruxandra McKinnon, Brigitte Kopp
Apple pomace is a waste product of the apple manufacturing industry that has been in the focus of life sciences as it represents a low-cost source of fruit-derived compounds. High fruit consumption is associated with beneficial health effects, and therefore, apple pomace and its constituents raise therapeutic interest. The present work reviews (i) the chemical constituents of apple pomace, (ii) optimized extraction methods of apple pomace compounds, and (iii) biological activities of apple pomace. Current evidence of apple pomace influence on digestion and metabolism, cholesterol and triglyceride homeostasis, diabetes, and sex hormones is summarized...
July 12, 2017: Planta Medica
https://www.readbyqxmd.com/read/28692897/fate-and-impacts-of-pharmaceuticals-and-personal-care-products-after-repeated-applications-of-organic-waste-products-in-long-term-field-experiments
#5
Marjolaine Bourdat-Deschamps, Sabrina Ferhi, Nathalie Bernet, Fréderic Feder, Olivier Crouzet, Dominique Patureau, Denis Montenach, Géraud D Moussard, Vincent Mercier, Pierre Benoit, Sabine Houot
Recycling organic waste products in agriculture is a potential route for the dispersion of pharmaceutical residues in the environment. In this study, the concentrations of thirteen pharmaceuticals and the personal care product triclosan (PPCPs) were determined in different environmental matrices from long-term experimental fields amended with different organic waste products (OWPs), including sludge, composted sludge with green wastes, livestock effluents and composted urban wastes applied at usual agricultural rates...
July 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28687152/valorisation-of-chicken-feathers-characterisation-of-chemical-properties
#6
Tamrat Tesfaye, Bruce Sithole, Deresh Ramjugernath, Viren Chunilall
The characterisation of the chemical properties of the whole chicken feather and its fractions (barb and rachis), was undertaken to identify opportunities for valorizing this waste product. The authors have described the physical, morphological, mechanical, electrical and thermal properties of the chicken feathers and related them to potential valorisation routes of the waste. However, identification of their chemical properties is necessary to complete a comprehensive description of chicken feather fractions...
July 4, 2017: Waste Management
https://www.readbyqxmd.com/read/28680802/lobster-processing-by-products-as-valuable-bioresource-of-marine-functional-ingredients-nutraceuticals-and-pharmaceuticals
#7
REVIEW
Trung T Nguyen, Andrew R Barber, Kendall Corbin, Wei Zhang
The worldwide annual production of lobster was 165,367 tons valued over $3.32 billion in 2004, but this figure rose up to 304,000 tons in 2012. Over half the volume of the worldwide lobster production has been processed to meet the rising global demand in diversified lobster products. Lobster processing generates a large amount of by-products (heads, shells, livers, and eggs) which account for 50-70% of the starting material. Continued production of these lobster processing by-products (LPBs) without corresponding process development for efficient utilization has led to disposal issues associated with costs and pollutions...
2017: Bioresources and Bioprocessing
https://www.readbyqxmd.com/read/28671222/automation-of-route-identification-and-optimisation-based-on-data-mining-and-chemical-intuition
#8
A A Lapkin, P K Heer, P-M Jacob, M Hutchby, W Cunningham, S D Bull, M G Davidson
Data-mining of Reaxys and network analysis of the combined literature and in-house reactions set were used to generate multiple possible reaction routes to convert a bio-waste feedstock, limonene, into a pharmaceutical API, paracetamol. The network analysis of data provides a rich knowledge-base for generation of the initial reaction screening and development programme. Based on the literature and the in-house data, an overall flowsheet for the conversion of limonene to paracetamol was proposed. Each individual reaction-separation step in the sequence was simulated as a combination of the continuous flow and batch steps...
July 3, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28647879/disposal-of-household-pharmaceuticals-in-insular-communities-social-attitude-behaviour-evaluation-and-prevention-activities
#9
Antonis A Zorpas, Maria Dimitriou, Irene Voukkali
The increase in medicine and drug consumption have resulted in identifying these emerging pollutants in all aquatic compartments, ranging from surface water and groundwater resources to the marine environment. Pharmaceuticals are an indispensable part of life today. A large number of pharmaceuticals are used in a daily basis in the treatment, prevention, cure or diagnosis of diseases or to otherwise enhance people's physical or mental well-being. This paper focuses on the evaluation of the attitude of citizens in Cyprus regarding the disposal of pharmaceuticals as well as to identify the main reasons why pharmaceutical wastes are produced...
June 25, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28598770/review-of-the-ecotoxicological-effects-of-emerging-contaminants-on-soil-biota
#10
Ana R Gomes, Celine Justino, Teresa Rocha-Santos, Ana C Freitas, Armando C Duarte, Ruth Pereira
In recent years, emerging contaminants (e.g. pesticides and their metabolites, pharmaceuticals, personal and house care products, life-style compounds, food additives, industrial products and wastes, as well as nanomaterials) have become a problem to the environment. In fact, the cumulative use of a panoply of chemical substances in agriculture, industrial activities, in our homes and in health care services has led to their recent appearance in detectable levels in soils, surface, and groundwater resources, with unpredictable consequences for these ecosystems...
June 9, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/28587908/elevating-4-hydroxycoumarin-production-through-alleviating-thioesterase-mediated-salicoyl-coa-degradation
#11
Xiaolin Shen, Monika Mahajani, Jia Wang, Yaping Yang, Qipeng Yuan, Yajun Yan, Yuheng Lin
Acyl-CoAs are essential intermediates in the biosynthetic pathways of a number of industrially and pharmaceutically important molecules. When these pathways are reconstituted in a heterologous microbial host for metabolic engineering purposes, the acyl-CoAs may be subject to undesirable hydrolysis by the host's native thioesterases, resulting in a waste of cellular energy and decreased intermediate availability, thus impairing bioconversion efficiency. 4-hydroxycoumarin (4HC) is a direct synthetic precursor to the commonly used oral anticoagulants (e...
June 3, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/28586753/ozonation-as-a-pretreatment-process-for-nanofiltration-brines-monitoring-of-transformation-products-and-toxicity-evaluation
#12
Antonin Azaïs, Julie Mendret, Guillaume Cazals, Eddy Petit, Stephan Brosillon
Considerable interest has been given to using nanofiltration (NF) in lieu of reverse osmosis for water reclamation schemes due to lower energy consumption, higher flux rates while ensuring good micropollutants rejection. The application NF results in the generation of a large concentrated waste stream. Treatment of the concentrate is a major hurdle for the implementation of membrane technologies since the concentrate is usually unusable due to a large pollutants content. This work focuses on the application of ozonation as pretreatment of urban NF concentrates, the generation of transformation products and their relative toxicity...
May 30, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28583329/rtd-modeling-of-a-continuous-dry-granulation-process-for-process-control-and-materials-diversion
#13
Julia Kruisz, Jakob Rehrl, Stephan Sacher, Isabella Aigner, Martin Horn, Johannes G Khinast
Disturbance propagation during continuous manufacturing processes can be predicted by evaluating the residence time distribution (RTD) of the specific unit operations. In this work, a dry granulation process was modelled and four scenarios of feeding events were simulated. We performed characterization of the feeders and developed RTD models for the blender and the roller compactor based on impulse-response measurements via color tracers. Out-of-specification material was defined based on the active pharmaceutical ingredient (API) concentration...
June 3, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28571909/the-presence-of-contaminations-in-sewage-sludge-the-current-situation
#14
Krzysztof Fijalkowski, Agnieszka Rorat, Anna Grobelak, Malgorzata J Kacprzak
Sewage sludge/biosolids are by-wastes of municipal and industrial wastewater treatment. As sources of nutrients (C, N, P) they are widely used in intensive farming where large supplementation of organic matter to maintain fertility and enhance crop yields is needed. However, according to the report of European Commission published in 2010, only 39% of produced sewage sludge is recycled into agriculture in the European Union. This situation occurs mainly due to the fact, that the sewage sludge may contain a dangerous volume of different contaminants...
May 29, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28566667/dermatophyte-antigen-kit
#15
Yuichiro Tsunemi
The dermatophyte antigen kit uses monoclonal antibodies that react with polysaccharides present in the dermatophyte cell wall to detect dermatophyte antigens in specimens based on the principle of immunochromatography. Clinical studies showed that the kit was very useful in the diagnosis of tinea unguium but not tinea pedis. The kit was therefore further developed as an in vitro diagnostic tool for tinea unguium and was approved by the Pharmaceuticals and Medical Devices Agency of Japan. The kit's extraction solution can extract antigens from nail specimens quickly and efficiently...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28561814/the-sma-trust-the-role-of-a-disease-focused-research-charity-in-developing-treatments-for-sma
#16
REVIEW
V Christie-Brown, J Mitchell, K Talbot
SMA is a rare hereditary neuromuscular disease that causes weakness and muscle wasting as a result of the loss of spinal motor neurons. In its most severe form, SMA is the commonest genetic cause of death in infants, and children with less severe forms of SMA face the prospect of lifelong disability from progressive muscle wasting, loss of mobility and limb weakness. The initial discovery of the defective gene has been followed by major advances in our understanding of the genetic, cellular and molecular basis of SMA, providing the foundation for a range of approaches to treatment, including gene therapy, antisense oligonucleotide treatments and more traditional drug-based approaches to slow or halt disease progression...
May 31, 2017: Gene Therapy
https://www.readbyqxmd.com/read/28539105/removal-of-sulfamethoxazole-and-diclofenac-from-water-strategies-involving-o3-and-h2o2
#17
Daniela S Gomes, Licínio M Gando-Ferreira, Rosa M Quinta-Ferreira, Rui C Martins
Diclofenac (DCF) and Sulfamethoxazole (SMX) are two of the most frequently detected pharmaceutical compounds in water and are hardly removed by biological treatment systems. The presence of H2O2 was investigated in the ozonation of these two compounds. Experiments were carried out with both using distilled water and secondary effluent from a municipal wastewater treatment plant spiked with pharmaceuticals. Chemical oxygen demand (COD) abatement rate improved when H2O2 was added at the beginning of the ozonation process and when the ozone inlet concentration increased, attaining a maximum value of 91% and simultaneously a lower ozone waste for a H2O2 initial concentration of 5 mM and an ozone inlet concentration of 20 g Nm(-3)...
June 8, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28530330/-the-sherlock-system-clinical-and-logistic-pharmaceutical-services
#18
Roni Leibowitz, Shahar Aflalo, Ornit Cohen, Ahuva Lustig
BACKGROUND: The drug inventory in the hospital consumes a large part of the hospital's budget. Classic drug management is based on weekly visits of the pharmacist in the departments, writing an order and dispensing it. This method is wasteful in terms of sending a bulk of drugs that will not necessarily be utilized, and it is also inefficient in terms of human resources. The unit-dose method, which is more advanced, is based on filling out individual prescriptions for each of the inpatients in the department...
August 2016: Harefuah
https://www.readbyqxmd.com/read/28494286/slurry-photocatalytic-membrane-reactor-technology-for-removal-of-pharmaceutical-compounds-from-wastewater-towards-cytostatic-drug-elimination
#19
REVIEW
Raphael Janssens, Mrinal Kanti Mandal, Kashyap Kumar Dubey, Patricia Luis
The potential of photocatalytic membrane reactors (PMR) to degrade cytostatic drugs is presented in this work as an emerging technology for wastewater treatment. Cytostatic drugs are pharmaceutical compounds (PhCs) commonly used in cancer treatment. Such compounds and their metabolites, as well as their degraded by-products have genotoxic and mutagenic effects. A major challenge of cytostatic removal stands in the fact that most drugs are delivered to ambulant patients leading to diluted concentration in the municipal waste...
December 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28476307/isolation-of-organic-compounds-with-high-added-values-from-agro-industrial-solid-wastes
#20
Dimitris P Zagklis, Christakis A Paraskeva
Phenols are organic compounds with high antioxidant activity. Occurring mainly in plants, where they act as pigments or even as part of defense mechanisms against insects and herbivores. Given the positive impact on on human health, their isolation and purification from agricultural products is of particular interest for the production of nutritional, pharmaceutical and cosmetics supplements. In our study different materials rich in phenolic compounds were used, in order to separate the phenolic content and maximum condensation using physicochemical methods such as solvent extraction, filtration through membranes, adsorption/desorption on resins and vacuum distillation...
May 2, 2017: Journal of Environmental Management
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