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https://www.readbyqxmd.com/read/29234706/adsorption-of-diclofenac-onto-different-biochar-microparticles-dataset-characterization-and-dosage-of-biochar
#1
Linson Lonappan, Tarek Rouissi, Satinder Kaur Brar, Mausam Verma, Rao Y Surampalli
Due to its wide occurrence in water resources and toxicity, pharmaceuticals and personal care products are becoming an emerging concern throughout the world. Application of residual/waste materials for water remediation can be a good strategy in waste management as well as in waste valorization. Herein, this dataset provides information on biochar application for the removal of emerging contaminant, diclofenac from water matrices. The data presented here is an extension of the research article explaining the mechanisms of adsorption diclofenac on biochars (Lonappan et al...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29229200/waste-based-alternative-adsorbents-for-the-remediation-of-pharmaceutical-contaminated-waters-has-a-step-forward-already-been-taken
#2
REVIEW
Carla Patrícia Silva, Guilaine Jaria, Marta Otero, Valdemar I Esteves, Vânia Calisto
When adsorption is considered for water treatment, commercial activated carbon is usually the chosen adsorbent for the removal of pollutants from the aqueous phase, particularly pharmaceuticals. In order to decrease costs and save natural resources, attempts have been made to use wastes as raw materials for the production of alternative carbon adsorbents. This approach intends to increase efficiency, cost-effectiveness, and also to propose an alternative and sustainable way for the valorization/management of residues...
December 2, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29208974/bioaccumulation-of-pharmaceuticals-and-personal-care-product-chemicals-in-fish-exposed-to-wastewater-effluent-in-an-urban-wetland
#3
Derek Muir, Denina Simmons, Xiaowa Wang, Tom Peart, Maria Villella, Jason Miller, Jim Sherry
The bioaccumulation of a broad range of pharmaceuticals and personal care product chemicals (PPCPs) was studied in Cootes Paradise Marsh (CPM), an urban wetland that receives tertiary treated municipal waste waters as well as urban storm runoff. We measured PPCPs in caged and wild goldfish, as well as wild carp, and compared observed bioaccumulation factors (BAFP) using concentrations in surface waters and fish blood plasma, with modeled BAFs. Thirty-two PPCPs were detected in water from the central CPM site (CPM3) while 64 PPCPs were found at higher concentrations at a site immediately downstream of the effluent outflow (CPM1)...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29197297/use-of-chemometrics-to-compare-nir-and-hplc-for-the-simultaneous-determination-of-drug-levels-in-fixed-dose-combination-tablets-employed-in-tuberculosis-treatment
#4
Kelly Sivocy Sampaio Teixeira, Said Gonçalves da Cruz Fonseca, Luís Carlos Brigido de Moura, Mario Luís Ribeiro de Moura, Márcia Herminia Pinheiro Borges, Euzébio Guimaraes Barbosa, Túlio Flávio Accioly De Lima E Moura
The World Health Organization recommends that TB treatment be administered using combination therapy. The methodologies for quantifying simultaneously associated drugs are highly complex, being costly, extremely time consuming and producing chemical residues harmful to the environment. The need to seek alternative techniques that minimize these drawbacks is widely discussed in the pharmaceutical industry. Therefore, the objective of this study was to develop and validate a multivariate calibration model in association with the near infrared spectroscopy technique (NIR) for the simultaneous determination of rifampicin, isoniazid, pyrazinamide and ethambutol...
November 23, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29179114/valorization-of-poly-ethylene-terephthalate-pet-wastes-into-magnetic-carbon-for-adsorption-of-antibiotic-from-water-characterization-and-application
#5
Premanjali Rai, Kunwar P Singh
Waste Polyethylene terephthalate (PET) bottles were pyrolyzed in the presence of nitrogen and converted into activated carbon (PETAC) by physical activation in carbon dioxide flow. An ex-situ precipitation and external reduction method were applied for the intercalation of ferromagnetic iron oxides onto the PETAC matrix. The characteristic structural and chemical properties of PETAC and magnetic PETAC (M-PETAC) were studied by Brunauer Emmett Teller (BET) surface area analysis, Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Fourier Transform Infrared (FTIR) analysis, Raman spectroscopy, X-Ray Diffraction (XRD) analysis, Energy Dispersive analysis of X-rays (EDAX), Vibrating Sample Magnetometer (VSM), Thermal gravimetric analysis (TGA) and elemental analysis...
November 24, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29170137/one-size-fits-all-dosing-in-oncology-wastes-money-innovation-and-lives
#6
EDITORIAL
David C Norris
Failure to individualize drug dosing may waste 50% of the value of pharmaceutical innovation coming off the bench, driving the unacceptable failure rates of drug development programs and unsustainable drug costs. An immense opportunity is thus presented to investors in pharmaceutical innovation who are willing to develop and field innovative Phase 1 trial methodologies that solve this problem. The principle of Dose Titration Algorithm Tuning (DTAT) offers a reasoned strategy for accomplishing this.
November 20, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/29167757/amino-acid-catabolism-directed-biofuel-production-in-clostridium-sticklandii-an-insight-into-model-driven-systems-engineering
#7
REVIEW
C Sangavai, P Chellapandi
Model-driven systems engineering has been more fascinating process for the microbial production of biofuel and bio-refineries in chemical and pharmaceutical industries. Genome-scale modeling and simulations have been guided for metabolic engineering of Clostridium species for the production of organic solvents and organic acids. Among them, Clostridium sticklandii is one of the potential organisms to be exploited as a microbial cell factory for biofuel production. It is a hyper-ammonia producing bacterium and is able to catabolize amino acids as important carbon and energy sources via Stickland reactions and the development of the specific pathways...
December 2017: Biotechnology Reports
https://www.readbyqxmd.com/read/29160452/technical-issues-and-conservation-conditions-of-medicines-in-the-primary-health-care-of-the-brazilian-unified-health-system
#8
Ediná Alves Costa, Patrícia Sodré Araújo, Marcelo Tavares Pereira, Ana Cristina Souto, Gisélia Santana Souza, Augusto Afonso Guerra, Francisco de Assis Acurcio, Ione Aquemi Guibu, Juliana Alvares, Karen Sarmento Costa, Margô Gomes de Oliveira Karnikowski, Orlando Mario Soeiro, Silvana Nair Leite
OBJECTIVE: To characterize the technical issues and conditions of medicines conservation in Primary Health Care of Brazilian regions, responsible for pharmacy/dispensing unit profile; environmental, storage, and dose fractioning conditions; inventory control and waste management; fire and electrical failure safety items; transportation problems; advertising regulation; and pharmacovigilance. METHODS: This article is part of the Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos - Serviços (National Survey on Access, Use and Promotion of Rational Use of Medicines - Services)-, a cross-sectional and exploratory study, of evaluative nature, consisting of an information survey within a representative sample of municipalities, stratified by Brazilian regions, which constitute the study domains, and a sample of Primary Health Care services...
November 13, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29156440/pharmaceutical-and-personal-care-products-induced-stress-symptoms-and-detoxification-mechanisms-in-cucumber-plants
#9
Chengliang Sun, Stacia Dudley, John Trumble, Jay Gan
Contamination of agricultural soils by pharmaceutical and personal care products (PPCPs) resulting from the application of treated wastewater, biosolids and animal wastes constitutes a potential environmental risk in many countries. To date a handful of studies have considered the phytotoxicity of individual PPCPs in crop plants, however, little is known about the effect of PPCPs as mixtures at environmentally relevant levels. This study investigated the uptake and transport, physiological responses and detoxification of a mixture of 17 PPCPs in cucumber seedlings...
November 17, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29154196/analysis-of-potential-genotoxic-impurities-in-rabeprazole-active-pharmaceutical-ingredient-via-liquid-chromatography-tandem-mass-spectrometry-following-quality-by-design-principles-for-method-development
#10
Katerina Iliou, Anđelija Malenović, Yannis L Loukas, Yannis Dotsikas
A novel Liquid Chromatography-tandem mass spectrometry (LC-MS/MS) method is presented for the quantitative determination of two potential genotoxic impurities (PGIs) in rabeprazole active pharmaceutical ingredient (API). In order to overcome the analytical challenges in the trace analysis of PGIs, a development procedure supported by Quality-by-Design (QbD) principles was evaluated. The efficient separation between rabeprazole and the two PGIs in the shortest analysis time was set as the defined analytical target profile (ATP) and to this purpose utilization of a switching valve allowed the flow to be sent to waste when rabeprazole was eluted...
November 12, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29153082/advances-in-sensing-and-biosensing-of-bisphenols-a-review
#11
REVIEW
Dhanjai, Ankita Sinha, Lingxia Wu, Xianbo Lu, Jiping Chen, Rajeev Jain
Bisphenols (BPs) are well known endocrine disrupting chemicals (EDCs) that cause adverse effects on the environment, biotic life and human health. BPs have been studied extensively because of an increasing concern for the safety of the environment and for human health. They are major raw materials for manufacturing polycarbonates, thermal papers and epoxy resins and are considered hazardous environmental contaminants. A vast array of sensors and biosensors have been developed for the sensitive screening of BPs based on carbon nanomaterials (carbon nanotubes, fullerenes, graphene and graphene oxide), quantum dots, metal and metal oxide nanocomposites, polymer nanocomposites, metal organic frameworks, ionic liquids and molecularly imprinted polymers...
January 15, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29151987/a-review-on-the-modification-of-polysaccharide-through-graft-copolymerization-for-various-potential-applications
#12
Deepak Kumar, Jyoti Pandey, Vinit Raj, Pramendra Kumar
Introduction: Graft copolymerization is one of the most promising technique uses to modify the properties of naturally available polymers with a minimum loss in their native characteristics. Methods and Materials: Graft copolymerization is a very significant technique to add hybrid properties in backbone of polymers. The grafting generally initiated through the formation of free radical centers on the polymer backbone as well as monomer. Results: Grafted polysaccharides have various applications in different important scientific areas such as drug delivery, pharmaceutical field, plastic industry, waste water treatment, tannery effluent treatment, textile industry, agriculture area, etc...
2017: Open Medicinal Chemistry Journal
https://www.readbyqxmd.com/read/29140522/ecodrug-a-database-connecting-drugs-and-conservation-of-their-targets-across-species
#13
Bas Verbruggen, Lina Gunnarsson, Erik Kristiansson, Tobias Österlund, Stewart F Owen, Jason R Snape, Charles R Tyler
Pharmaceuticals are designed to interact with specific molecular targets in humans and these targets generally have orthologs in other species. This provides opportunities for the drug discovery community to use alternative model species for drug development. It also means, however, there is potential for mode of action related effects in non-target wildlife species as many pharmaceuticals reach the environment through patient use and manufacturing wastes. Acquiring insight in drug target ortholog predictions across species and taxonomic groups has proven difficult because of the lack of an optimal strategy and because necessary information is spread across multiple and diverse sources and platforms...
November 11, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29133323/characteristics-and-healthcare-utilisation-patterns-of-high-cost-beneficiaries-in-the-netherlands-a-cross-sectional-claims-database-study
#14
Joost Johan Godert Wammes, Marit Tanke, Wilma Jonkers, Gert P Westert, Philip Van der Wees, Patrick Pt Jeurissen
OBJECTIVE: To determine medical needs, demographic characteristics and healthcare utilisation patterns of the top 1% and top 2%-5% high-cost beneficiaries in the Netherlands. DESIGN: Cross-sectional study using 1 year claims data. We broke down high-cost beneficiaries by demographics, the most cost-incurring condition per beneficiary and expensive treatment use. SETTING: Dutch curative health system, a health system with universal coverage...
November 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/29126124/predicting-drug-safety-and-communicating-risk-benefits-of-a-bayesian-approach
#15
Stanley E Lazic, Nicholas Edmunds, Christopher E Pollard
Drug toxicity is a major source of attrition in drug discovery and development. Pharmaceutical companies routinely use preclinical data to predict clinical outcomes and continue to invest in new assays to improve predictions. However, there are many open questions about how to make the best use of available data, combine diverse data, quantify risk, and communicate risk and uncertainty to enable good decisions. The costs of suboptimal decisions are clear: resources are wasted and patients may be put at risk...
November 6, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29116077/convenient-iron-catalyzed-reductive-aminations-without-hydrogen-for-selective-synthesis-of-n-methylamines
#16
Kishore Natte, Helfried Neumann, Rajenahally V Jagadeesh, Matthias Beller
N-Methylated amines play an important role in regulating the biological and pharmaceutical properties of all kinds of life science molecules. In general, this class of compounds is synthesized via reductive amination reactions using high pressure of molecular hydrogen. Thus, on laboratory scale especially in drug discovery, activated (toxic) methyl compounds such as methyl iodide and dimethyl sulfate are still employed, which also generate significant amounts of waste. Therefore, the development of more convenient and operationally simple processes for the synthesis of advanced N-methylamines is highly desired...
November 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/29073579/removal-of-organic-micropollutants-in-waste-stabilisation-ponds-a-review
#17
REVIEW
Yolanta Gruchlik, Kathryn Linge, Cynthia Joll
As climate change and water scarcity continue to be of concern, reuse of treated wastewater is an important water management strategy in many parts of the world, particularly in developing countries and remote communities. Many countries, especially in remote regional areas, use waste stabilisation ponds (WSPs) to treat domestic wastewater for a variety of end uses, including using the treated wastewater for irrigation of public spaces (e.g. parks and ovals) or for crop irrigation. Thus, it is vital that the resulting effluent meets the required quality for beneficial reuse...
October 23, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29066885/asymmetric-dumbbell-shaped-silver-nanoparticles-and-spherical-gold-nanoparticles-green-synthesized-by-mangosteen-garcinia-mangostana-pericarp-waste-extracts
#18
Ji Su Park, Eun-Young Ahn, Youmie Park
Mangosteen (Garcinia mangostana) pericarp waste extract was used to synthesize gold and silver nanoparticles by a green strategy. The extract was both a reducing and stabilizing agent during synthesis. Phytochemical screening of the extract was conducted to obtain information regarding the presence/absence of primary and secondary metabolites in the extract. The in vitro antioxidant activity results demonstrated that the extract had excellent antioxidant activity, which was comparable to a standard (butylated hydroxy toluene)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29039333/antioxidant-antibacterial-and-antiproliferative-activities-of-pumpkin-cucurbit-peel-and-puree-extracts-an-in-vitro-study
#19
Muhammad Asif, Syed Ali Raza Naqvi, Tauqir A Sherazi, Matloob Ahmad, Ameer Fawad Zahoor, Sohail Anjum Shahzad, Zaib Hussain, Hassan Mahmood, Nasir Mahmood
Natural resources right from the beginning of the human civilization has paved the way to human being to combat different challenges. The big challenge was to safe the human being from diseases and shortage of food. Plants helped the man in both areas very efficiently. No doubt when plants are used as food actually we are also taking lot of compounds of medicinal values in an excellent combination which naturally reduce the risk of diseases. Extraction and purification of several medicinally important compounds also gave the way to develop pharmaceutical industry in addition to its own therapeutic effects against different lethal diseases...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28990769/rapid-and-concomitant-analysis-of-pharmaceuticals-in-treated-wastewater-by-coated-blade-spray-mass-spectrometry
#20
Justen J Poole, German A Gómez-Ríos, Ezel Boyaci, Nathaly Reyes-Garcés, Janusz Pawliszyn
The widespread use of pharmaceuticals in both human and animal populations, and the resultant contamination of surface waters from the outflow of water treatment facilities is an issue of growing concern. This has raised the need for analytical methods that can both perform rapid sample analysis and overcome the limitations of conventional analysis procedures, such as multistep workflows and tedious procedures. Coated blade spray (CBS) is a solid-phase microextraction based technique that enables the direct-to-mass-spectrometry analysis of extracted compounds via the use of limited organic solvent to desorb analytes and perform electrospray ionization...
November 7, 2017: Environmental Science & Technology
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