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https://www.readbyqxmd.com/read/28539105/removal-of-sulfamethoxazole-and-diclofenac-from-water-strategies-involving-o3-and-h2o2
#1
Daniela S Gomes, Licínio M Gando-Ferreira, Rosa M Quinta-Ferreira, Rui C Martins
Diclofenac (DCF) and Sulfamethoxazole (SMX) are two of the most frequently detected pharmaceutical compounds in water and are hardly removed by biological treatment systems. The presence of H2O2 was investigated in the ozonation of these two compounds. Experiments were carried out with both using distillated water and secondary effluent from a municipal wastewater treatment plant (WWTP) spiked with pharmaceuticals. Chemical oxygen demand (COD) abatement rate improved when H2O2 was added at the beginning of the ozonation process and when the ozone inlet concentration increased, attaining a maximum value of 91% and simultaneously a lower ozone waste for a H2O2 initial concentration of 5 mM and an ozone inlet concentration of 20 g Nm(-3)...
May 25, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28530330/-the-sherlock-system-clinical-and-logistic-pharmaceutical-services
#2
Roni Leibowitz, Shahar Aflalo, Ornit Cohen, Ahuva Lustig
BACKGROUND: The drug inventory in the hospital consumes a large part of the hospital's budget. Classic drug management is based on weekly visits of the pharmacist in the departments, writing an order and dispensing it. This method is wasteful in terms of sending a bulk of drugs that will not necessarily be utilized, and it is also inefficient in terms of human resources. The unit-dose method, which is more advanced, is based on filling out individual prescriptions for each of the inpatients in the department...
August 2016: Harefuah
https://www.readbyqxmd.com/read/28494286/slurry-photocatalytic-membrane-reactor-technology-for-removal-of-pharmaceutical-compounds-from-wastewater-towards-cytostatic-drug-elimination
#3
REVIEW
Raphael Janssens, Mrinal Kanti Mandal, Kashyap Kumar Dubey, Patricia Luis
The potential of photocatalytic membrane reactors (PMR) to degrade cytostatic drugs is presented in this work as an emerging technology for wastewater treatment. Cytostatic drugs are pharmaceutical compounds (PhCs) commonly used in cancer treatment. Such compounds and their metabolites, as well as their degraded by-products have genotoxic and mutagenic effects. A major challenge of cytostatic removal stands in the fact that most drugs are delivered to ambulant patients leading to diluted concentration in the municipal waste...
May 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28476307/isolation-of-organic-compounds-with-high-added-values-from-agro-industrial-solid-wastes
#4
Dimitris P Zagklis, Christakis A Paraskeva
Phenols are organic compounds with high antioxidant activity. Occurring mainly in plants, where they act as pigments or even as part of defense mechanisms against insects and herbivores. Given the positive impact on on human health, their isolation and purification from agricultural products is of particular interest for the production of nutritional, pharmaceutical and cosmetics supplements. In our study different materials rich in phenolic compounds were used, in order to separate the phenolic content and maximum condensation using physicochemical methods such as solvent extraction, filtration through membranes, adsorption/desorption on resins and vacuum distillation...
May 2, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28420596/the-behaviors-and-experiences-of-the-community-pharmacy-team-on-the-provision-of-multi-compartment-compliance-aids
#5
Derek Stewart, Craig McDonald, Joan MacLeod, Katie MacLure, Gwen Gray, Trudi McIntosh
BACKGROUND: Multi-compartment compliance aids (MCAs) are repackaging systems for solid dosage form medicines. Acknowledging the lack of evidence that MCAs improve adherence or clinical outcomes, the Royal Pharmaceutical Society has expressed concern that MCAs have 'become regarded as a panacea for medicines use'. OBJECTIVES: To determine the behaviors and experiences of the community pharmacy team around MCA provision. METHODS: A cross-sectional survey was conducted in 26 community pharmacies in the north east of Scotland...
April 9, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28403748/an-effective-method-of-atelocollagen-type-1-3-isolation-from-human-placenta-and-its-in-vitro-characterization-in-two-dimesional-and-three-dimensional-cell-culture-applications
#6
Johannes Hackethal, Severin Mühleder, Alexandra Hofer, Karl Heinrich Schneider, Johanna Prüller, Simone Hennerbichler, Heinz Redl, Andreas Teuschl
Pepsin-solubilized atelocollagen can be used to form highly complex three-dimensional matrices for a broad spectrum of tissue engineering applications. Moreover, it has a long history as a favorable biomaterial in pharmaceutical and medical industries. So far, the main sources for these approaches are collagens from xenogenic sources. Yet, these nonhuman collagens carry a risk of provoking immune reactions in patients. Here we describe an effective method of isolating atelocollagen type 1/3 (COL1/3) from human placenta...
May 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28399848/distinctive-molecular-and-biochemical-characteristics-of-a-glycoside-hydrolase-family-20-%C3%AE-n-acetylglucosaminidase-and-salt-tolerance
#7
Junpei Zhou, Zhifeng Song, Rui Zhang, Rui Liu, Qian Wu, Junjun Li, Xianghua Tang, Bo Xu, Junmei Ding, Nanyu Han, Zunxi Huang
BACKGROUND: Enzymatic degradation of chitin has attracted substantial attention because chitin is an abundant renewable natural resource, second only to lignocellulose, and because of the promising applications of N-acetylglucosamine in the bioethanol, food and pharmaceutical industries. However, the low activity and poor tolerance to salts and N-acetylglucosamine of most reported β-N-acetylglucosaminidases limit their applications. Mining for novel enzymes from new microorganisms is one way to address this problem...
April 11, 2017: BMC Biotechnology
https://www.readbyqxmd.com/read/28393216/cancer-induced-cardiac-cachexia-pathogenesis-and-impact-of-physical-activity-review
#8
Yassine Belloum, Françoise Rannou-Bekono, François B Favier
Cachexia is a wasting syndrome observed in many patients suffering from several chronic diseases including cancer. In addition to the progressive loss of skeletal muscle mass, cancer cachexia results in cardiac function impairment. During the severe stage of the disease, patients as well as animals bearing cancer cells display cardiac atrophy. Cardiac energy metabolism is also impeded with disruption of mitochondrial homeostasis and reduced oxidative capacity, although the available data remain equivocal. The release of inflammatory cytokines by tumor is a key mechanism in the initiation of heart failure...
May 2017: Oncology Reports
https://www.readbyqxmd.com/read/28390750/implementing-ecopharmacovigilance-epv-from-a-pharmacy-perspective-a-focus-on-non-steroidal-anti-inflammatory-drugs
#9
REVIEW
Jun Wang, Bingshu He, Dan Yan, Xiamin Hu
Environmental experts have made great efforts to control pharmaceutical pollution. However, the control of emerged environmental problems caused by medicines should draw more attention of pharmacy and pharmacovigilance researchers. Ecopharmacovigilance (EPV) as a kind of pharmacovigilance for the environment is recognized worldwide as crucial to minimize the environmental risk of pharmaceutical pollutants. But continuing to treat the pollution of pharmaceuticals as a group of substances instead of targeting individual pharmaceuticals on a prioritized basis will lead to a significant waste of resources...
April 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28387154/production-of-polyhydroxyalkanoates-pha-using-sludge-from-different-wastewater-treatment-processes-and-the-potential-for-medical-and-pharmaceutical-applications
#10
Wai Lam, Yujie Wang, Pui Ling Chan, Shun Wan Chan, Yiu Fai Tsang, Hong Chua, Peter Hoi Fu Yu
In this study, seven strains of bacteria with polyhydroxyalkanoates (PHA)-producing ability (i.e. Bacillus cereus, Pseudomonas putida, Bacillus pumilus, Pseudomona huttiensis, Yersinia frederiksenii, Aeromonas ichthiosmia, and Sphingopyxis terrae) were isolated from various waste treatment plants in Hong Kong. Simultaneous wastewater treatment and PHA accumulation were successfully achieved in the bioreactors using isolated bacteria from different sludges. At the organic loading less than 13,000 ppm, more than 95% of chemical oxygen demand (COD) was removed by the isolated strains before the decrease of PHA accumulation...
April 20, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28371770/occurrence-of-antibiotic-resistance-genes-and-mobile-genetic-elements-in-enterococci-and-genomic-dna-during-anaerobic-digestion-of-pharmaceutical-waste-sludge-with-different-pretreatments
#11
Juan Tong, XueTing Lu, JunYa Zhang, Qianwen Sui, Rui Wang, Meixue Chen, Yuansong Wei
Pharmaceutical waste sludge harbors large amounts of antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs), and it is necessary to study the reduction of ARGs and MGEs during sludge treatment. Therefore, the antibiotic resistance phenotypes and genotypes of enterococci, and the ARGs and MGEs in genomic DNA were investigated during anaerobic digestion (AD) with microwave (MW), thermal hydrolysis (TH) and ozone pretreatment. Results showed that sludge pretreatment increased the occurrence of the resistance phenotypes and genotypes of enterococci...
March 22, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28333214/-forever-young-%C3%A2-testosterone-replacement-therapy-a-blockbuster-drug-despite-flabby-evidence-and-broken-promises
#12
Andrea Busnelli, Edgardo Somigliana, Paolo Vercellini
In the last decade, testosterone replacement therapy (TRT) has been increasingly prescribed to treat a controversial condition known as 'late-onset hypogonadism (LOH)'. This syndrome is diagnosed in men who, for no discernible reason other than older age, obesity or ill health have serum testosterone concentrations below the normal range for healthy young men and report one or more of the following symptoms: muscle weakness or wasting, mood, behaviour and cognition-related symptoms and sexual function or libido impairment...
April 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28330246/microbial-enzymes-industrial-progress-in-21st-century
#13
REVIEW
Rajendra Singh, Manoj Kumar, Anshumali Mittal, Praveen Kumar Mehta
Biocatalytic potential of microorganisms have been employed for centuries to produce bread, wine, vinegar and other common products without understanding the biochemical basis of their ingredients. Microbial enzymes have gained interest for their widespread uses in industries and medicine owing to their stability, catalytic activity, and ease of production and optimization than plant and animal enzymes. The use of enzymes in various industries (e.g., food, agriculture, chemicals, and pharmaceuticals) is increasing rapidly due to reduced processing time, low energy input, cost effectiveness, nontoxic and eco-friendly characteristics...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28328933/water-borne-pharmaceuticals-reduce-phenotypic-diversity-and-response-capacity-of-natural-phytoplankton-communities
#14
Francesco Pomati, Jukka Jokela, Sara Castiglioni, Mridul K Thomas, Luca Nizzetto
Chemical micropollutants occur worldwide in the environment at low concentrations and in complex mixtures, and how they affect the ecology of natural systems is still uncertain. Dynamics of natural communities are driven by the interaction between individual organisms and their growth environment, which is mediated by the organisms' expressed phenotypic traits. We tested whether exposure to a mixture of 12 pharmaceuticals and personal care products (PPCP) influences phenotypic trait diversity in lake phytoplankton communities and their ability to regulate biomass production to fit environmental changes (response capacity)...
2017: PloS One
https://www.readbyqxmd.com/read/28325591/global-scanning-of-antihistamines-in-the-environment-analysis-of-occurrence-and-hazards-in-aquatic-systems
#15
Lauren A Kristofco, Bryan W Brooks
Concentration of the global population is increasingly occurring in megacities and other developing regions, where access to medicines is increasing more rapidly than waste management systems are implemented. Because freshwater and coastal systems are influenced by wastewater effluent discharges of differential quality, exposures in aquatic systems must be considered. Here, we performed a global scanning assessment of antihistamines (AHs), a common class of medicines, in surface waters and effluents. Antihistamines were identified, literature occurrence and ecotoxicology data on AHs collated, therapeutic hazard values (THVs) calculated, and environmental exposure distributions (EEDs) of AHs compared to ecotoxicity thresholds and drug specific THVs to estimate hazards in surface waters and effluents...
March 18, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28314666/microbial-oil-a-plausible-alternate-resource-for-food-and-fuel-application
#16
REVIEW
B Bharathiraja, Sridevi Sridharan, V Sowmya, D Yuvaraj, R Praveenkumar
Microbes have recourse to low-priced substrates like agricultural wastes and industrial efflux. A pragmatic approach towards an emerging field- the exploitation of microbial oils for biodiesel production, pharmaceutical and cosmetic applications, food additives, biopolymer production will be of immense remunerative significance in the near future. Due to high free fatty acid, nutritive content and simpler solvent extraction processes of microbial oils with plant oil, microbial oils can back plant oils in food applications...
March 6, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28297682/degradation-of-organic-pollutants-by-bio-inspired-rectangular-and-hexagonal-titanium-dioxide-nanostructures
#17
T V M Sreekanth, Jae-Jin Shim, Yong Rok Lee
Dyes are used in textile, printing, leather, pharmaceutical, food and cosmetic industries. Dyes add color and pattern to materials. The presence of even very low concentration of dyes/dyes degradation products in effluent is highly toxic to humans and aquatic organisms. It is important to remove these dye degradation pollutants from the industrial effluents before their disposal. In recent years nanoparticles have been used for the removal of dyes from industrial waste water. Titanium dioxide nanostructures (TiO2 NS) were synthesized via a one-step facile green process...
April 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28284869/minimizing-e-factor-in-the-continuous-flow-synthesis-of-diazepam-and-atropine
#18
Anne-Catherine Bédard, Ashley R Longstreet, Joshua Britton, Yuran Wang, Hideki Moriguchi, Robert W Hicklin, William H Green, Timothy F Jamison
Minimizing the waste stream associated with the synthesis of active pharmaceutical ingredients (APIs) and commodity chemicals is of high interest within the chemical industry from an economic and environmental perspective. In exploring solutions to this area, we herein report a highly optimized and environmentally conscious continuous-flow synthesis of two APIs identified as essential medicines by the World Health Organization, namely diazepam and atropine. Notably, these approaches significantly reduced the E-factor of previously published routes through the combination of continuous-flow chemistry techniques, computational calculations and solvent minimization...
February 4, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28284641/photochemical-transformation-and-wastewater-fate-and-occurrence-of-omeprazole-hrms-for-elucidation-of-transformation-products-and-target-and-suspect-screening-analysis-in-wastewaters
#19
Christina I Kosma, Dimitra A Lambropoulou, Triantafyllos A Albanis
Omeprazole is one of the world-wide most frequently prescribed and administered pharmaceuticals in humans for the relief of gastro-intestinal disorders. Despite its high worldwide consumption, omeprazole is rarely detected in urban wastewaters and environmental waters. On the other hand, its human urinary metabolites and transformation products formed through abiotic processes in the environment have been recently documented. Despite these available data, however, there is still a lack of information on the extent of environmental fate and occurrence, on elimination mechanisms and efficiencies in waste water treatment plants...
March 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28281107/cannabis-for-pain-and-headaches-primer
#20
REVIEW
Philip S Kim, Michael A Fishman
PURPOSE OF REVIEW: Marijuana has been used both medicinally and recreationally since ancient times and interest in its compounds for pain relief has increased in recent years. The identification of our own intrinsic, endocannabinoid system has laid the foundation for further research. RECENT FINDINGS: Synthetic cannabinoids are being developed and synthesized from the marijuana plant such as dronabinol and nabilone. The US Food and Drug Administration approved the use of dronabinol and nabilone for chemotherapy-associated nausea and vomiting and HIV (Human Immunodeficiency Virus) wasting...
April 2017: Current Pain and Headache Reports
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