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https://www.readbyqxmd.com/read/28098803/optimization-of-the-production-of-1-phenylethanol-using-enzymes-from-flowers-of-tea-camellia-sinensis-plants
#1
Fang Dong, Ying Zhou, Lanting Zeng, Naoharu Watanabe, Xinguo Su, Ziyin Yang
1-Phenylethanol (1PE) can be used as a fragrance in food flavoring and cosmetic industries and as an intermediate in the pharmaceutical industry. 1PE can be synthesized from acetophenone, and the cost of 1PE is higher than the cost of acetophenone. Therefore, it is important to establish an effective and low-cost approach for producing 1PE. Our previous studies found that tea (Camellia sinensis) flowers, which are an abundant and waste resource, contained enzymes that could transform acetophenone to 1PE. In the present study, we extracted crude enzymes from tea flowers and optimized the production conditions of 1PE using response surface methodology...
January 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28092003/validated-electrochemical-and-chromatographic-quantifications-of-some-antibiotic-residues-in-pharmaceutical-industrial-waste-water
#2
Heba K Ibrahim, Mona M Abdel-Moety, Sherif A Abdel-Gawad, Medhat A Al-Ghobashy, Mohamed Abdel Kawy
Realistic implementation of ion selective electrodes (ISEs) into environmental monitoring programs has always been a challenging task. This could be largely attributed to difficulties in validation of ISE assay results. In this study, the electrochemical response of amoxicillin trihydrate (AMX), ciprofloxacin hydrochloride (CPLX), trimethoprim (TMP), and norfloxacin (NFLX) was studied by the fabrication of sensitive membrane electrodes belonging to two types of ISEs, which are polyvinyl chloride (PVC) membrane electrodes and glassy carbon (GC) electrodes...
January 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28088705/ultrasonic-compaction-of-granular-geological-materials
#3
Andrew Feeney, Sakalima Sikaneta, Patrick Harkness, Margaret Lucas
It has been shown that the compaction of granular materials for applications such as pharmaceutical tableting and plastic moulding can be enhanced by ultrasonic vibration of the compaction die. Ultrasonic vibrations can reduce the compaction pressure and increase particle fusion, leading to higher strength products. In this paper, the potential benefits of ultrasonics in the compaction of geological granular materials in downhole applications are explored, to gain insight into the effects of ultrasonic vibrations on compaction of different materials commonly encountered in sub-sea drilling...
January 5, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28069357/control-strategies-for-drug-product-continuous-direct-compression-state-of-control-product-collection-strategies-and-startup-shutdown-operations-for-the-production-of-clinical-trial-materials-and-commercial-products
#4
Ahmad Almaya, Lawrence De Belder, Robert Meyer, Karthik Nagapudi, Hung-Ren Homer Lin, Ian Leavesley, Jayanthy Jayanth, Gurjit Bajwa, James DiNunzio, Anthony Tantuccio, Dan Blackwood, Admassu Abebe
Continuous Manufacturing (CM) has emerged in the pharmaceutical industry as a paradigm shift with significant advantages related to cost, efficiency, flexibility and higher assurance of quality. The inherent differences from batch processes justify examining the CM control strategy more holistically. This paper describes the current thinking for the control and implementation of CM, using the example of a direct compression process and taking into consideration the ICH Q10 definition of "state of control" and process validation requirements...
January 6, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28061902/disposal-practices-of-unused-and-expired-pharmaceuticals-among-general-public-in-kabul
#5
Mohammadk Bashaar, Vijay Thawani, Mohamed Azmi Hassali, Fahad Saleem
BACKGROUND: Most of the medicine users remain unaware about the disposal of unused or expired medicines. The aim of this study was to know the disposal practices of unused and expired medicines among the general public in Kabul. METHODS: This was a descriptive, cross-sectional survey, conducted through face-to-face interviews using prevalidated structured questionnaire. Returned questionnaires were double-checked for accuracy. Statistical Package for Social Science (SPSS) version 23 was used for statistical analysis...
January 7, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28046131/biological-recovery-of-platinum-complexes-from-diluted-aqueous-streams-by-axenic-cultures
#6
Synthia Maes, Ruben Props, Jeffrey P Fitts, Rebecca De Smet, Frank Vanhaecke, Nico Boon, Tom Hennebel
The widespread use of platinum in high-tech and catalytic applications has led to the production of diverse Pt loaded wastewaters. Effective recovery strategies are needed for the treatment of low concentrated waste streams to prevent pollution and to stimulate recovery of this precious resource. The biological recovery of five common environmental Pt-complexes was studied under acidic conditions; the chloro-complexes PtCl42- and PtCl62-, the amine-complex Pt(NH3)4Cl2 and the pharmaceutical complexes cisplatin and carboplatin...
2017: PloS One
https://www.readbyqxmd.com/read/28042854/in-vitro-anti-thrombotic-activity-of-extracts-from-blacklip-abalone-haliotis-rubra-processing-waste
#7
Hafiz Ansar Rasul Suleria, Barney M Hines, Rama Addepalli, Wei Chen, Paul Masci, Glenda Gobe, Simone A Osborne
Waste generated from the processing of marine organisms for food represents an underutilized resource that has the potential to provide bioactive molecules with pharmaceutical applications. Some of these molecules have known anti-thrombotic and anti-coagulant activities and are being investigated as alternatives to common anti-thrombotic drugs, like heparin and warfarin that have serious side effects. In the current study, extracts prepared from blacklip abalone (Haliotis rubra) processing waste, using food grade enzymes papain and bromelain, were found to contain sulphated polysaccharide with anti-thrombotic activity...
December 31, 2016: Marine Drugs
https://www.readbyqxmd.com/read/28030781/effects-of-solid-liquid-separation-and-storage-on-monensin-attenuation-in-dairy-waste-management-systems
#8
Sarah C Hafner, Naoko Watanabe, Thomas Harter, Brian A Bergamaschi, Sanjai J Parikh
Environmental release of veterinary pharmaceuticals has been of regulatory concern for more than a decade. Monensin is a feed additive antibiotic that is prevalent throughout the dairy industry and is excreted in dairy waste. This study investigates the potential of dairy waste management practices to alter the amount of monensin available for release into the environment. Analysis of wastewater and groundwater from two dairy farms in California consistently concluded that monensin is most present in lagoon water and groundwater downgradient of lagoons...
December 25, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/28024752/nationwide-reconnaissance-of-contaminants-of-emerging-concern-in-source-and-treated-drinking-waters-of-the-united-states
#9
Susan T Glassmeyer, Edward T Furlong, Dana W Kolpin, Angela L Batt, Robert Benson, J Scott Boone, Octavia Conerly, Maura J Donohue, Dawn N King, Mitchell S Kostich, Heath E Mash, Stacy L Pfaller, Kathleen M Schenck, Jane Ellen Simmons, Eunice A Varughese, Stephen J Vesper, Eric N Villegas, Vickie S Wilson
When chemical or microbial contaminants are assessed for potential effect or possible regulation in ambient and drinking waters, a critical first step is determining if the contaminants occur and if they are at concentrations that may cause human or ecological health concerns. To this end, source and treated drinking water samples from 29 drinking water treatment plants (DWTPs) were analyzed as part of a two-phase study to determine whether chemical and microbial constituents, many of which are considered contaminants of emerging concern, were detectable in the waters...
December 23, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/28018307/variable-effects-of-non-steroidal-anti-inflammatory-drugs-nsaids-on-selected-biochemical-processes-mediated-by-soil-microorganisms
#10
Mariusz Cycoń, Sławomir Borymski, Bartłomiej Żołnierczyk, Zofia Piotrowska-Seget
Non-steroidal anti-inflammatory drugs (NSAIDs) are the most frequently used group of pharmaceuticals. The high consumption and the uncontrolled disposal of unused drugs into municipal waste or their deposit in landfills can result in an increased concentration of these compounds in soils. Moreover, these drugs can affect the microbial activity. However, there is a lack of knowledge about these effects or it is very limited. Therefore, the objective of this study was to compare the impact of selected commercially available NSAIDs, i...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27981967/cooperative-redox-activation-for-carbon-dioxide-conversion
#11
Zhong Lian, Dennis U Nielsen, Anders T Lindhardt, Kim Daasbjerg, Troels Skrydstrup
A longstanding challenge in production chemistry is the development of catalytic methods for the transformation of carbon dioxide into useful chemicals. Silane and borane promoted reductions can be fined-tuned to provide a number of C1-building blocks under mild conditions, but these approaches are limited because of the production of stoichiometric waste compounds. Here we report on the conversion of CO2 with diaryldisilanes, which through cooperative redox activation generate carbon monoxide and a diaryldisiloxane that actively participate in a palladium-catalysed carbonylative Hiyama-Denmark coupling for the synthesis of an array of pharmaceutically relevant diarylketones...
December 16, 2016: Nature Communications
https://www.readbyqxmd.com/read/27981403/de-novo-transcriptome-sequencing-and-analysis-of-freshwater-snail-radix-balthica-to-discover-genes-and-pathways-affected-by-exposure-to-oxazepam
#12
Jean-Yves Mazzitelli, Elsa Bonnafe, Christophe Klopp, Frédéric Escudier, Florence Geret
Pharmaceuticals are increasingly found in aquatic ecosystems due to the non-efficiency of waste water treatment plants. Therefore, aquatic organisms are frequently exposed to a broad diversity of pharmaceuticals. Freshwater snail Radix balthica has been chosen as model to study the effects of oxazepam (psychotropic drug) on developmental stages ranging from trochophore to hatching. In order to provide a global insight of these effects, a transcriptome deep sequencing has been performed on exposed embryos. Eighteen libraries were sequenced, six libraries for three conditions: control, exposed to the lowest oxazepam concentration with a phenotypic effect (delayed hatching) (TA) and exposed to oxazepam concentration found in freshwater (TB)...
January 2017: Ecotoxicology
https://www.readbyqxmd.com/read/27943623/challenges-on-the-road-to-a-multicellular-bioartificial-liver
#13
REVIEW
Viktoriia Starokozhko, Geny M M Groothuis
Over the past years the progress in the development of a bioartificial liver (BAL) as an extracorporeal device or as a tissue engineered transplantable organ has been immense. However, many important BAL characteristics that are necessary to meet clinical demands, have not been sufficiently addressed. This review describes the existing challenges in the development of a BAL for clinical applications, highlighting multicellularity and sinusoidal microarchitecture as crucial BAL characteristics to fulfill various liver functions...
December 12, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27936635/carbon-hydrogen-and-chlorine-stable-isotope-fingerprinting-for-forensic-investigations-of-hexachlorocyclohexanes
#14
Natalija Ivdra, Anko Fischer, Sara Herrero-Martin, Thomas Giunta, Magali Bonifacie, Hans-Hermann Richnow
Multielemental stable isotope analysis of persistent organic pollutants (POPs) has the potential to characterize sources, sinks, and degradation processes in the environment. To verify the applicability of this approach for source identification of hexachlorocyclohexane (HCHs), we provide a data set of carbon, hydrogen, and chlorine stable isotope ratios (δ(13)C, δ(2)H, δ(37)Cl) of its main stereoisomers (α-, β-, δ- and γ-HCHs) from a sample collection based on worldwide manufacturing. This sample collection comprises production stocks, agricultural and pharmaceutical products, chemical waste dumps, and analytical-grade material, covering the production time period from the late 1960s until now...
January 3, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/27933140/mitigating-pharmaceutical-waste-exposures-policy-and-program-considerations
#15
EDITORIAL
Eric D Amster
Pharmaceutical disposal and the environmental fate of medication metabolites directly impacts the public's health in two significant ways: accidental medication ingestion of pharmaceuticals that were not disposed of properly results in inadvertent toxicity; and environmental health consequences of pharmaceuticals that were inappropriately disposed and which contaminate municipal water supply. In reviewing the effectiveness of medication disposal policy globally, it is crucial to not only determine which policies are effective but also to assess why they are effective...
2016: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/27931375/chemical-waste-and-allied-products
#16
Yung-Tse Hung, Hamidi Abdul Aziz, Siti Fatihah Ramli, Ruth Yu-Li Yeh, Lian-Huey Liu, Christopher Robert Huhnke
This review of literature published in 2015 focuses on waste related to chemical and allied products. The topics cover the waste management, physicochemical treatment, aerobic granular, aerobic waste treatment, anaerobic granular, anaerobic waste treatment, chemical waste, chemical wastewater, fertilizer waste, fertilizer wastewater, pesticide wastewater, pharmaceutical wastewater, ozonation. cosmetics waste, groundwater remediation, nutrient removal, nitrification denitrification, membrane biological reactor, and pesticide waste...
October 2016: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/27922103/hypothalamic-activation-is-essential-for-endotoxemia-induced-acute-muscle-wasting
#17
Kaipeng Duan, Qiyi Chen, Minhua Cheng, Chenyan Zhao, Zhiliang Lin, Shanjun Tan, Fengchan Xi, Tao Gao, Jialiang Shi, Juanhong Shen, Weiqin Li, Wenkui Yu, Jieshou Li, Ning Li
Growing evidence suggests acute skeletal muscle wasting is a key factor affecting nutritional support and prognosis in critical patients. Previously, plenty of studies of muscle wasting focused on the peripheral pathway, little was known about the central role. We tested the hypothesis whether central inflammatory pathway and neuropeptides were involved in the process. In lipopolysaccharide (LPS) treated rats, hypothalamic NF-κB pathway and inflammation were highly activated, which was accompanied with severe muscle wasting...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27919554/quantitative-structure-property-relationships-for-predicting-sorption-of-pharmaceuticals-to-sewage-sludge-during-waste-water-treatment-processes
#18
L Berthod, D C Whitley, G Roberts, A Sharpe, R Greenwood, G A Mills
Understanding the sorption of pharmaceuticals to sewage sludge during waste water treatment processes is important for understanding their environmental fate and in risk assessments. The degree of sorption is defined by the sludge/water partition coefficient (Kd). Experimental Kd values (n=297) for active pharmaceutical ingredients (n=148) in primary and activated sludge were collected from literature. The compounds were classified by their charge at pH7.4 (44 uncharged, 60 positively and 28 negatively charged, and 16 zwitterions)...
February 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27898796/sorption-of-pharmaceuticals-heavy-metals-and-herbicides-to-biochar-in-the-presence-of-biosolids
#19
Daniel A Bair, Fungai N D Mukome, Inna E Popova, Temitope A Ogunyoku, Allie Jefferson, Daoyuan Wang, Sarah C Hafner, Thomas M Young, Sanjai J Parikh
Agricultural practices are increasingly incorporating recycled waste materials, such as biosolids, to provide plant nutrients and enhance soil functions. Although biosolids provide benefits to soil, municipal wastewater treatment plants receive pharmaceuticals and heavy metals that can accumulate in biosolids, and land application of biosolids can transfer these contaminants to the soil. Environmental exposure of these contaminants may adversely affect wildlife, disrupt microbial communities, detrimentally affect human health through long-term exposure, and cause the proliferation of antibiotic-resistant bacteria...
November 2016: Journal of Environmental Quality
https://www.readbyqxmd.com/read/27829614/vegetable-oil-deodorizer-distillate-a-rich-source-of-the-natural-bioactive-components
#20
Syed Tufail Hussain Sherazi, Sarfaraz Ahmed Mahesar, Sirajuddin
Deodorizer distillates are waste products of edible oil processing industries obtained during deodorization process of vegetable oils. It is very cheap source of several health beneficial components such as tocopherols, sterols, squalene as well as free fatty acids which have numerous industrial applications. These valuable components are being used in different foods, pharmaceutical formulations and cosmetics. Traditional sources of these useful components are vegetable oils, fruits, vegetables and nuts. Global need of these important components has been exceeded than their availability...
December 1, 2016: Journal of Oleo Science
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