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Spinal tumours

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https://www.readbyqxmd.com/read/29143901/combined-vertebral-augmentation-and-radiofrequency-ablation-in-the-management-of-spinal-metastases-an-update
#1
REVIEW
Ning Mao Kam, Julian Maingard, Hong Kuan Kok, Dinesh Ranatunga, Duncan Brooks, William C Torreggiani, Peter L Munk, Michael J Lee, Ronil V Chandra, Hamed Asadi
Spinal metastases are the most commonly encountered tumour of the spine, occurring in up to 40% of patients with cancer. Each year, approximately 5% of cancer patients will develop spinal metastases. This number is expected to increase as the life expectancy of cancer patients increases. Patients with spinal metastases experience severe and frequently debilitating pain, which often decreases their remaining quality of life. With a median survival of less than 1 year, the goals of treatment in spinal metastases are reducing pain, improving or maintaining level of function and providing mechanical stability...
November 16, 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29140834/prognostic-factors-in-patients-with-metastatic-spinal-cord-compression-secondary-to-melanoma-a-systematic-review
#2
Nicholas J Hadden, Jerome R D McIntosh, Samuel Jay, Paula J Whittaker
Melanoma is one of the most common primary tumours associated with metastatic spinal cord compression (MSCC). The aim of this review is to identify prognostic factors specifically for MSCC secondary to melanoma. A systematic search of literature was performed in MEDLINE, Embase and the Cochrane Library to identify studies reporting prognostic factors for patients with MSCC secondary to melanoma. Two studies, involving a total of 39 patients, fulfilled the inclusion criteria. The variables associated with increased survival were receiving postoperative radiotherapy, receiving chemotherapy, perioperative lactate dehydrogenase level less than or equal to 8...
November 14, 2017: Melanoma Research
https://www.readbyqxmd.com/read/29131086/intracranial-epidural-haematoma-following-surgical-removal-of-a-giant-lumbosacral-schwannoma-a-case-report-and-literature-review
#3
Jakob Nemir, Vjerislav Peterković, Ines Trninić, Ivan Domazet, Hrvoje Barić, Miroslav Vukić
Postoperative intracranial epidural haematoma (EDH) is an extremely rare complication following spinal surgery, with only a handful of cases described in the literature. We report the case of a 16-year-old girl who underwent a successful subtotal resection of a giant lumbosacral schwannoma (L2-S2 level). Recovery from general anaesthesia was uneventful; however, her neurological status deteriorated rapidly within 24 h after surgery. A head computed tomography scan revealed a large right frontoparietal EDH with midline shift...
November 11, 2017: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29073497/therapeutic-approaches-for-protecting-bone-health-in-patients-with-breast-cancer
#4
REVIEW
Diana Lüftner, Daniela Niepel, Guenther G Steger
Improvements in the survival of patients with breast cancer, together with a better understanding of the pathology of the disease, have led to the emergence of bone health as a key aspect of patient management. Patients with breast cancer are typically at risk of skeletal complications throughout their disease course. The receptor activator of nuclear factor κ B ligand (RANKL) inhibitor denosumab and bisphosphonates (e.g. zoledronic acid) are approved in Europe for the prevention of skeletal-related events (pathologic fracture, radiation or surgery to bone, and spinal cord compression) in adults with bone metastases secondary to solid tumours...
October 23, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29071122/diagnostic-algorithm-prognostic-factors-and-surgical-treatment-of-metastatic-cancer-diseases-of-the-long-bones-and-spine
#5
REVIEW
Miklós Szendrői, Imre Antal, Attila Szendrői, Áron Lazáry, Péter Pál Varga
Oncological management of skeletal metastases has changed dramatically in the last few decades. A significant number of patients survive for many years with their metastases.Surgeons are more active and the technical repertoire is broader, from plates to intramedullary devices to (tumour) endoprostheses.The philosophy of treatment should be different in the case of a trauma-related fracture and a pathological fracture. A proper algorithm for establishing a diagnosis and evaluation of prognostic factors helps in planning the surgical intervention...
September 2017: EFORT open reviews
https://www.readbyqxmd.com/read/29057366/spinal-tumour-primary-cervical-extradural-meningioma-at-an-unusual-location
#6
Ishita Pant, Vinod Kumar Singh Gautam, Rima Kumari, Sujata Chaturvedi
Extradural spinal meningiomas are extremely rare, more so in the cervical region. A purely extradural location as reported in this paper is quite exceptional. The authors report a case of extradural meningioma in a 50-year-old male located in the cervical spine that was surgically treated with the provisional diagnosis of a neurofibroma. Histopathological diagnosis of meningothelial meningioma was made with the routine hematoxylin and eosin (HE) stain. The origin, clinical course, radiological features, pathological findings with the differential diagnosis and surgical treatment are discussed based on a review of the literature...
September 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29057339/composite-peek-carbon-fiber-implants-can-increase-the-effectiveness-of-radiotherapy-in-the-management-of-spine-tumors
#7
Giuseppe Tedesco, Alessandro Gasbarrini, Stefano Bandiera, Riccardo Ghermandi, Stefano Boriani
BACKGROUND: Combination of surgery and radiotherapy in the treatment of primary spine tumour can be indicated in some cases where a satisfactory oncological margin cannot be achieved. The presence of metal hardware has always limited post-operative radiotherapy due to the scattering effects of ionizing radiation or particles. The use of a fixation system (including rods and screw) fully made in PEEK embedded Carbon fiber (CFR-PEEK) could make easier and more effective the post-operative radiotherapy as it is radiolucent and does not interfere with ionizing radiation and accelerated particles...
September 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29052449/resveratrol-in-management-of-bone-and-spinal-cancers
#8
Gang Chen, Hong Xia, Zhi-Guo Zhang, Hai-Liang Yu
Bone cancer is a malignant primary tumour of the bone with different typing, such as, osteosarcoma, chondrosarcoma, Ewing's sarcoma and fibrosarcoma. Despite the clinical efficacy of conventional therapies of bone cancer, most patients eventually relapse and the disease remains incurable. Therefore, new therapeutic strategies are needed to improve patient outcome. In this review article, we have discussed the role of resveratrol in preventing bone and spinal cancers and therapeutics. Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a natural polyphenol, which has been widely reported as an anticancer molecule...
October 20, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29024203/megestrol-acetate-caused-adrenal-insufficiency-and-delayed-puberty-in-a-male-adolescent-with-spinal-tumour
#9
Chutima Leelalertlauw, Pat Mahachoklertwattana, Suradej Hongeng, Preamrudee Poomthavorn
No abstract text is available yet for this article.
October 12, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29021680/nondysraphic-cervicomedullary-intramedullary-lipoma
#10
Sujeet Kumar Meher, Laxmi Narayan Tripathy, Harsh Jain, Sunandan Basu
Spinal cord lipomas are usually associated with spinal dysraphism and is most common in lumbosacral region. Spinal intradural lipoma is a rare condition accounting for less than 1% of spinal cord tumours and is most prevalent in cervicodorsal region. Intramedullary spinal cord lipoma of cervical spine not associated with spinal dysraphism is one of the rarest lesions. They usually present insidiously with slowly progressive myelopathic deficits. We present a case of nondysraphic intramedullary spinal cord lipoma with exophytic component and intracranial extension...
July 2017: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/28987657/feasibility-of-percutaneous-cryoablation-of-vertebral-metastases-under-local-anaesthesia-in-asaiii-patients
#11
Alessandro Motta, Giuseppe Caltabiano, Stefano Palmucci, Giovanni Failla, Antonio Basile
PURPOSE: spine metastases are common concern from several primary neoplasms, modern management include percutaneous techniques such as ablation and cementoplasty. This research aims to evaluate the treatment under local anaesthesia in high-risk patients (ASA III). METHODS AND MATERIAL: from January 2013 up to September 2016 we treated via percutaneous cryoablation 11 advanced oncological patients classified as ASA III, then retrospectively a review of their clinical history has been performed...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28955476/periaortic-lymphoma-in-a-cat
#12
Laura Bree, Chiara Bergamino, Ronan Mullins, Pamela Kelly, Robert Shiel
CASE SUMMARY: A 14-year-old neutered male Siamese cat was presented with a 3 month history of lethargy, inappetence, dehydration, hindlimb ataxia and intermittent proprioceptive deficits in the hindlimbs. Physical examination revealed low body condition score (1.75/5), pallor and bilateral basilar grade II/VI systolic heart murmur. Neurological examination revealed hindlimb ataxia, severe atrophy of the hindlimb musculature, intermittent hindlimb proprioceptive deficits and normoreflexia...
July 2017: JFMS open reports
https://www.readbyqxmd.com/read/28939631/tnf-blockers-inhibit-spinal-radiographic-progression-in-ankylosing-spondylitis-by-reducing-disease-activity-results-from-the-swiss-clinical-quality-management-cohort
#13
Christoph Molnar, Almut Scherer, Xenofon Baraliakos, Manouk de Hooge, Raphael Micheroli, Pascale Exer, Rudolf O Kissling, Giorgio Tamborrini, Lukas M Wildi, Michael J Nissen, Pascal Zufferey, Jürg Bernhard, Ulrich Weber, Robert B M Landewé, Désirée van der Heijde, Adrian Ciurea
OBJECTIVES: To analyse the impact of tumour necrosis factor inhibitors (TNFis) on spinal radiographic progression in ankylosing spondylitis (AS). METHODS: Patients with AS in the Swiss Clinical Quality Management cohort with up to 10 years of follow-up and radiographic assessments every 2 years were included. Radiographs were scored by two readers according to the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) with known chronology. The relationship between TNFi use before a 2-year radiographic interval and progression within the interval was investigated using binomial generalised estimating equation models with adjustment for potential confounding and multiple imputation of missing values...
September 22, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28935367/from-symptom-to-diagnosis-the-prediagnostic-symptomatic-interval-of-pediatric-central-nervous-system-tumors-in-austria
#14
Amedeo A Azizi, Kirsten Heßler, Ulrike Leiss, Chryssa Grylli, Monika Chocholous, Andreas Peyrl, Johannes Gojo, Irene Slavc
BACKGROUND: Children with central nervous system (CNS) tumours may present with a multitude of symptoms, ranging from elevated intracranial pressure to focal neurological deficit. In everyday practice, some signs may be misleading, thereby causing prolonged prediagnostic symptomatic intervals. Prediagnostic symptomatic intervals are longer for pediatric brain tumors than for other childhood malignancies. This study evaluated prediagnostic symptomatic intervals and parental and diagnostic intervals for pediatric patients with CNS tumours in Austria...
August 18, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28890232/complete-progressive-ophthalmoplegia-and-numb-chin-syndrome-the-first-clinical-manifestations-of-a-lethal-abdominal-burkitt-lymphoma
#15
Smaranda Maier, Rodica Bălaşa, Zoltan Bajko, Iunius Simu, Emoke Horvath
A 57-year-old patient was admitted to the Neurology Clinic for hypoesthesia, intense pain in the right chin and double vision. During the hospitalization, the patient developed progressive complete bilateral ophthalmoplegia and numbness of both sides of the chin. Brain CT and MRI scans with gadolinium were normal. Standard laboratory tests on admission were normal. The cerebral spinal fluid examination and the infectious and autoimmune workup were also normal. A thoracic-abdominal and pelvic CT scan revealed two hypodense lesions in the liver, irregular thickening of the gastric and ileal wall, and multiple abdominal adenopathies...
August 18, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28890157/the-cumulative-burden-of-surviving-childhood-cancer-an-initial-report-from-the-st-jude-lifetime-cohort-study-sjlife
#16
Nickhill Bhakta, Qi Liu, Kirsten K Ness, Malek Baassiri, Hesham Eissa, Frederick Yeo, Wassim Chemaitilly, Matthew J Ehrhardt, Johnnie Bass, Michael W Bishop, Kyla Shelton, Lu Lu, Sujuan Huang, Zhenghong Li, Eric Caron, Jennifer Lanctot, Carrie Howell, Timothy Folse, Vijaya Joshi, Daniel M Green, Daniel A Mulrooney, Gregory T Armstrong, Kevin R Krull, Tara M Brinkman, Raja B Khan, Deo K Srivastava, Melissa M Hudson, Yutaka Yasui, Leslie L Robison
BACKGROUND: Survivors of childhood cancer develop early and severe chronic health conditions (CHCs). A quantitative landscape of morbidity of survivors, however, has not been described. We aimed to describe the cumulative burden of curative cancer therapy in a clinically assessed ageing population of long-term survivors of childhood cancer. METHODS: The St Jude Lifetime Cohort Study (SJLIFE) retrospectively collected data on CHCs in all patients treated for childhood cancer at the St Jude Children's Research Hospital who survived 10 years or longer from initial diagnosis and were 18 years or older as of June 30, 2015...
September 7, 2017: Lancet
https://www.readbyqxmd.com/read/28890028/a-novel-technique-for-placement-of-sacro-alar-iliac-s2ai-screws-by-k-wire-insertion-using-intraoperative-navigation
#17
Kevin Phan, Julian Li, Gloria Giang, Ian Teng, Steven Phan, Nicholas Chang, Ralph Mobbs
Sacral-iliac fixation techniques may be indicated in the management of various lumbosacral pathologies including spinal degeneration, infection, tumour resection, fracture, pseudarthrosis, correction of spinal deformities involving long fusion constructs to the sacrum and cases with poor sacral fixation. There are a number of options for lumbosacral fixation each with their own advantages and disadvantages. Though S2-alar-iliac (S2AI) have demonstrated promising advantages over alternatives, the complex anatomy of the spinopelvic region demands precise insertion of the screws to create a biomechanically robust construct safely...
November 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28882936/ganglioneuroma-of-the-retropharyngeal-space-in-a-patient-with-glottic-cancer
#18
Raquel Baptista Dias, Duarte Rosa, Miguel Rito, Alexandra Borges
We describe the case of a 71-year-old man with a ganglioneuroma of the retropharyngeal space. The patient presented with a submucosal bulge of the left oropharyngeal wall during follow-up examination of a treated vocal cord carcinoma. CT and MRI revealed a non-specific, well-defined retropharyngeal soft tissue lesion. Positron emission tomography-CT did not show relevant metabolic activity, excluding the hypothesis of metastatic nodal disease. Surgical biopsy of the lesion was compatible with ganglioneuroma...
September 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28851495/intensity-modulated-radiotherapy-in-head-and-neck-cancer-an-update-for-oral-and-maxillofacial-surgeons
#19
REVIEW
P A Brennan, K L Bradley, M Brands
Intensity-modulated radiation therapy (IMRT), a relatively new method of delivering radiotherapy, can precisely target a point within a specific tumour and reduce the dose to nearby anatomical structures. This is particularly important in the head and neck where radiotherapy can easily and irreparably damage the salivary glands, spinal cord, and eyes, and where, with increasingly better outcomes and survival, late complications of conventional radiotherapy (including osteoradionecrosis of the cervical spine) can be difficult to manage...
October 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/28839322/breast-cancer-in-a-patient-with-kindlers-syndrome
#20
Itrat Mehdi, Bassim Jaffar Al Bahrani, Taha Mohsin Al Lawati, Zahid Al Mandhari, Fatima Ramadhan Al Lawati
Breast Cancer (BC) has associated risk factors and genetic factors like BRCA1, and BRCA2. Many benign and malignant disease processes are found concurrently with BC and believed to be additional risk factors like gall bladder stones (cholelithiasis), hypertension, diabetes mellitus, cerebrovascular lesions, arthritis, spine and spinal cord degenerative lesions, infertility, depression, sleep disturbances, obesity, autoimmune diseases (SLE), and thyroid diseases. There are some malignant disease associations like synchronous or metachronous ovarian, colonic and endometrial tumours with Breast cancer...
August 2017: JPMA. the Journal of the Pakistan Medical Association
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