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Ankita Sharma, Monu, Sagarika Biswas
BACKGROUND: Transthyretin (TTR) is the transporter protein (55 kDA) that carries retinol binding protein and thyroxin (T4) in its functional tetramer form. Presence of mutation in this protein (TTR) may lead to the dissociation of tetramers to monomer which unfolds and self associates to form amyloid aggregates. Aggregation of this protein has been found to be associated with various life threatening disorders such as coronary artery disease (CAD) which is the major cause of mortality and morbidity worldwide...
March 20, 2018: Current Computer-aided Drug Design
Gökhan Artaş, Şehmus Pala, Tuncay Kuloğlu, Remzi Atilgan, Şeyda Yavuzkir, Alparslan Akyol
The aim of this study was to compare the effects of only aspiration with aspiration and 5% trichloroacetic acid (TCA) application on ovarian cyst size and ovarian reserve. The ovarian cysts of 14 rats that were divided into two groups randomly were investigated after total salpingectomy procedure. G1 was the group of saline application after cyst aspiration, while in G2, after aspiration 5% TCA at half amount of aspiration volume was injected into the cyst and re-aspirated after five minutes. The abdomens of the rats were closed and re-explored after 1 month...
March 22, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Arif Emre, Sami Akbulut, Mehmet Sertkaya, Muharrem Bitiren, Ilhami Taner Kale, Ertan Bulbuloglu, Cemil Colak
AIM: To evaluate whether there was any correlation between the clinical parameters and final pathological results among patients who underwent thyroid surgery. METHODS: We retrospectively analyzed parameters, including age, sex, complete blood cell count parameters, nodule diameter, nodule localization, thyroid function testing, and pathology reports, in patients who underwent thyroid surgery. The patients were divided into malignant ( n = 92) and benign ( n = 413) groups depending on the final pathological results...
March 16, 2018: World Journal of Clinical Cases
Chenghao Jiang, Tong Cheng, Xucai Zheng, Shikai Hong, Song Liu, Jianjun Liu, Jing Wang, Shengying Wang
Objective: This study was to evaluate the risk factors of survival in patients with columnar cell variant (CCV) and encapsulated variant (ECV). Materials and methods: The Surveillance, Epidemiology, and End Results database (1988-2013) was used to compare the characteristics of CCV and ECV with those of classic papillary thyroid carcinoma (PTC). Survival was analyzed by the Kaplan-Meier method, the log-rank test, and Cox multivariate regression. Multivariate logistic regression was used to further analyze lymph node metastases and distant metastasis...
2018: Cancer Management and Research
Mingjun Gu
Aim: Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Infiltrative growth and metastasis are the two most intractable characteristics of PTC. Interleukin-13 receptor α2 (IL13Rα2) with high affinity for Th2-derived cytokine IL-13 has been reported to be overexpressed in several tumors. In this study, an analysis of IL13Rα2 expression in PTC and matched paracancerous tissues was undertaken, and its biologic functions in PTC were assessed. Methods: IL13Rα2 and vascular endothelial growth factor (VEGF) expression were detected by using real-time polymerase chain reaction and immunohistochemistry analyses...
2018: OncoTargets and Therapy
Samskruthi P Murthy, Deepak Balasubramanian, Adharsh Anand, Shashikant Vishnubhai Limbachiya, Narayana Subramaniam, Vasantha Nair, Krishnakumar Thankappan, Subramania Iyer
Differentiated thyroid cancers (DTC) are seen with increasing incidence in clinical practice. These tumours have good prognosis and the extent of surgery can be tailored to the size and pathological characteristics of the lesion. Historically total thyroidectomy was the recommended procedure for tumours >1 cm; however, current recommendations suggest a more conservative approach. This review focuses on the evolution of the extent of surgery in differentiated thyroid cancer.
March 2018: Indian Journal of Surgical Oncology
Chandan Kumar Jha, Vinita Agrawal, Anjali Mishra, P K Pradhan
Occult follicular thyroid carcinoma (FTC) presenting as distant metastases is a rare occurrence. However, despite being occult in majority of these cases, primary tumor can be detected on thyroid imaging or during surgery. Here, we present an extremely rare case of an occult FTC with overt skeletal metastases in which primary tumor was discernible only on microscopic examination.
March 2018: Indian Journal of Surgical Oncology
Anish Jacob Cherian, Pooja Ramakant, Rekha Pai, Marie Therese Manipadam, S Elanthenral, Anuradha Chandramohan, Julie Hephzibah, David Mathew, Dhukabandhu Naik, Thomas V Paul, Simon Rajaratnam, Nihal Thomas, M J Paul, Deepak Thomas Abraham
We conducted this study to evaluate the demography, clinical presentation, management and outcomes of medullary thyroid carcinoma (MTC) from the Indian context. This was a retrospective study of patients with MTC managed between January 2008 and December 2016. All pertinent data was collected and the results were analysed using STATA (v.13.1). MTC accounted for 90/2022 (4.45%) patients managed with thyroid cancer during the study period. The mean age of presentation was 40 years (range 14-70 years) with 47 males and 43 females...
March 2018: Indian Journal of Surgical Oncology
Balaji Zacharia, Dhiyaneswaran Subramaniam, Jerin Joy
Metastasis is the commonest bone tumors. The commonest primary metastasis to the bone are the breast, lung, prostate, kidney, and thyroid. The bone is the third common site of metastatic disease, only the lung and the liver have higher metastatic rate than skeleton. We have no epidemiological studies conducted to evaluate the various aspects of skeletal metastasis like age, sex distribution, presentation, common sites of primary and associated secondary metastases, and investigation from Indian subcontinent...
March 2018: Indian Journal of Surgical Oncology
U S Vishal Rao, Shrinidhi Koya, Sowjanya Gandla, Sataksi Chatterjee, Ashutosh A Patil, Ravi C Nayar, Kumar Kallur
The incidence of small differentiated thyroid carcinomas is increasing worldwide in the recent years, especially tumours of size less than 2 cm in diameter. In this study, we have analysed the patterns of behaviour of small-sized thyroid carcinomas (<2 cm, T1 tumours) in comparison with large-sized thyroid carcinomas. This is a retrospectively analysed data of patients with thyroid carcinoma. The following parameters were analysed: distribution with regard to age, sex and the presence of metastasis based on radioiodine scan...
March 2018: Indian Journal of Surgical Oncology
Elizabeth Mathew Iype, Santhosh Kumar N, Sreekanth S Kumar, Bipin T Varghese, Jaya C Jose
To study the clinicopathological and molecular factors which correlate with nodal metastasis in laryngeal and hypopharyngeal carcinoma, a retrospective analysis of 170 patients who underwent surgery for laryngeal and hypopharyngeal carcinoma at RCC, Trivandrum from 2006 to 2010 was done. The pathological nodal stage and levels of involvement were correlated with the clinicopathologic features of the primary disease. Neck node positivity was significantly more for lesions of pyriform sinus lesion (61%), with thyroid cartilage erosion (56%) and with base tongue involvement (88%)...
March 2018: Indian Journal of Surgical Oncology
Chitresh Kumar, Anjali Mishra, Niraj Kumari, Narendra Krishnani, Gyan Chand, Gaurav Agarwal, Amit Agarwal, Saroj Kanta Mishra
The importance of capsular invasion in follicular thyroid carcinoma (FTC) has not been extensively studied. The aim of the present study was to correlate the clinical features and outcome of FTC with histology features particularly emphasizing on the importance of the number of foci of capsular invasion. This was a retrospective study. Histology of 123 FTC patients was reviewed. Patients were divided in three groups based on the number of foci of vascular and capsular invasion noted in primary tumor: group 1-capsular invasion at <6 and vascular invasion at <4 foci, group 2-either capsular invasion ≥6 or vascular invasion at ≥4 foci, and group 3-capsular invasion ≥6 and vascular invasion at ≥4 foci...
March 2018: Indian Journal of Surgical Oncology
Benzon M Dy, Ashok R Shaha
Thyroid cancer commonly metastasizes to lymph nodes either in the central compartment or lateral neck in at least 50% of patients. Over the past several decades, our understanding of the natural progression of thyroid cancer has changed. Our current practice reflects our increasingly sophisticated understanding of the biology of thyroid cancer while taking into account the morbidity and mortality associated with aggressive variants of the disease.
March 2018: Indian Journal of Surgical Oncology
Giovanni E Lombardo, Valentina Maggisano, Marilena Celano, Donato Cosco, Chiara Mignogna, Federica Baldan, Saverio M Lepore, Lorenzo Allegri, Sonia Moretti, Cosimo Durante, Giuseppe Damante, Massimo Fresta, Diego Russo, Stefania Bulotta, Efisio Puxeddu
The high frequency of hTERT-promoting mutations and the increased expression of hTERT mRNA in anaplastic thyroid cancer (ATC) make TERT a suitable molecular target for the treatment of this lethal neoplasm. In this study, we encapsulated an anti-hTERT oligonucleotide in biocompatible nanoparticles and analyzed the effects of this novel pharmaceutical preparation in preclinical models of ATC. Biocompatible nanoparticles were obtained in an acidified aqueous solution containing chitosan, anti-hTERT oligoRNAs and poloxamer 188 as a stabilizer...
March 21, 2018: Molecular Cancer Therapeutics
Ioanna Kosteria, Christina Kanaka-Gantenbein, Athanasios K Anagnostopoulos, George P Chrousos, George Th Tsangaris
The principles of Predictive, Preventive and Personalized Medicine (PPPM) dictate the need to recognize individual susceptibility to disease in a timely fashion and to offer targeted preventive interventions and treatments. Proteomics is a state-of-the art technology- driven science aiming at expanding our understanding of the pathophysiologic mechanisms that underlie disease, but also at identifying accurate predictive, diagnostic and therapeutic biomarkers, that will eventually promote the implementation of PPPM...
March 18, 2018: Journal of Proteomics
Sonja Badovinac, Marta Korsic, Kamelija Zarkovic, Davorka Mursic, Mihovil Roglic, Marko Jakopovic, Miroslav Samarzija
AIM: Alongside the proven efficacy, immunotherapy in treatment of malignant diseases can cause immune-related adverse events different from commonly known chemotherapy-related toxicities. CASE PRESENTATION: During nivolumab treatment of metastatic squamous cell lung cancer, the patient developed a symptomatic inflammatory myositis confirmed with muscle biopsy and primary hypothyroidism. After initiation of corticosteroids and thyroid hormone replacement, the clinical and laboratory improvement occurred...
March 1, 2018: Immunotherapy
Jessa E Miller, Neal C Al-Attar, Owen H Brown, Gabrielle G Shaughness, Natalja P Rosculet, Anca Avram, David T Hughes
BACKGROUND: After initial surgical treatment of differentiated thyroid cancer (DTC) residual lymph node metastases are often found at the time of radioactive iodine (131-I) therapy. Recurrence of DTC is due to persistent disease not removed at initial surgery and that did not respond to 131-I treatment. This study aims to determine locations of, and reasons for, residual nodal metastases detected by 131-I scans with SPECT/CT obtained prior to radioiodine therapy following surgical treatment of DTC...
March 21, 2018: Thyroid: Official Journal of the American Thyroid Association
Kyu Young Choi, Jin Hwan Kim, Il Seok Park, Young Soo Rho, Gee Hwan Kwon, Dong Jin Lee
BACKGROUND: Cervical lymph node metastases (LNM) in papillary thyroid carcinomas (PTCs) are common and develop in approximately 30-80% of PTCs. The presence of cervical LNM significantly increases the rate of locoregional recurrence in PTCs. OBJECTIVE: To search for predictive gene signatures for nodal metastasis in PTCs. METHODS: We used unsupervised clustering with unbiased manner to compare molecular profiles between PTCs with nodal metastasis and PTCs without nodal metastasis using mRNA-seq of TCGA data...
March 1, 2018: Cancer Biomarkers: Section A of Disease Markers
Y Sahin, O Evliyaoglu, T Erkan, F C Cokugras, O Ercan, T Kutlu
BACKGROUND AND AIMS: Although the presence of autoimmune thyroiditis (AT) in celiac disease (CD) has been well documented among adults, CD in AT has been less reported in children. We aimed to investigate the frequency of CD in children with AT. Materials and Methods : This prospective study was carried out from October 2015 to August 2016 and included 66 patients with AT. Firstly, total IgA and tissue transglutaminase antibody (tTG) IgA levels were measured. Those with increased level of tTG IgA were tested for anti-endomysium IgA antibodies (EMA)...
January 2018: Acta Gastro-enterologica Belgica
E J F Peixoto de Miranda, M S Bittencourt, H L Staniak, R Sharovsky, A C Pereira, M Foppa, I S Santos, P A Lotufo, I M Benseñor
Data on the association between subclinical thyroid dysfunction and coronary artery disease (CAD) is scarce. We aimed to analyze the association between thyroid function and CAD using baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). We included subjects with normal thyroid function (0.4-4.0 mIU/L, and normal free thyroxine, FT4, or 0.8 to 1.9 ng/dL), subclinical hypothyroidism (SCHypo; TSH>4.0 mIU/L and normal FT4), and subclinical hyperthyroidism (SCHyper; TSH<0.4 mIU/L and normal FT4) evaluated by coronary computed tomography angiography...
March 15, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
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