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Head of pancreas tumor

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https://www.readbyqxmd.com/read/28336499/radical-resection-of-the-pancreas-should-not-always-be-necessary-in-the-surgical-management-of-pancreatic-solid-pseudopapillary-tumor-in-children
#1
Emre Divarcı, Zafer Dökümcü, Nazan Çetingül, Deniz Nart, Funda Yılmaz Barbet, Orkan Ergün, Ahmet Çelik
BACKGROUND/AIMS: Pancreatic solid pseudopapillary tumor (SPT) is a rare neoplasm in children. In this study, we aimed to present our surgical strategy based on minimal resection by enucleation or limited resection in localized pancreatic SPT. MATERIALS AND METHODS: We retrospectively analyzed the medical records of children who underwent surgical resection between October 2011 and September 2016. RESULTS: Five female patients with a median age of 15 years (range, 14-17 years) were operated...
March 23, 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/28327418/solid-pseudopapillary-neoplasm-case-report-of-a-rare-pancreatic-tumor
#2
Cláudio Branco, Sónia Vilaça, Joaquim Falcão
INTRODUCTION: Solid pseudopapillary neoplasm (SPN) is a rare pancreatic tumor. Most patients are female within the second or third decade of life with only a small minority concerning children. Frequently described as low malignant potential tumors, surgical resection remains the main treatment. PRESENTATION OF CASE: The authors present a case of a SPN diagnosed in a 17-year-old Caucasian girl with vomiting and abdominal pain localized to the right upper quadrant...
February 28, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28316225/-the-clinical-impact-of-artery-first-approach-combined-with-vascular-resection-and-reconstruction-in-the-treatment-of-pancreatic-head-carcinoma
#3
J L Huang, W G Li, F Z Chen, Z J Su, F M Li, B Liu
Objective: To evaluate the application of artery first, combined vascular resection and reconstruction in the treatment of pancreatic head carcinoma. Methods: The clinical data of 13 patients with pancreatic head cancer were retrospectively analyzed from February 2014 to March 2016 in the Affiliated Hospital of Xiamen University. Preoperative computed tomography of high resolution layer or magnetic resonance imaging examination demonstrated pancreatic head carcinoma, as well as close adhesion, stenosis, compression or displacement of superior mesenteric vein or portal vein wall...
March 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28316222/-the-clinical-characteristics-surgical-procedures-and-prognosis-of-solid-pseudopapillary-tumor-of-the-pancreas
#4
H Yang, N Li, W Y Deng, S X Luo
Objective: To explore the clinical characteristics, surgical procedures and prognosis of solid pseudopapillary tumor of the pancreas(SPTP). Methods: The clinical and follow-up data of 55 cases with SPTP in Henan Tumor Hospital from June 2005 to April 2015 were retrospectively analyzed. Results: There were 55 SPTP cases, including 7 males and 48 females. The age ranged from 16 to 76 (median, 33). Clinical presentations of SPTP were not specific. The mean size of the tumor was 7.6 cm (range from 2 to 25cm). Pancreatic head and tail were the most common locations of SPTP...
March 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28291009/a-family-with-von-hippel-lindau-syndrome-the-findings-of-indium-111-somatostatin-receptor-scintigraphy-iodine-123-metaiodobenzylguanidine-scintigraphy-and-single-photon-emission-computerized-tomography
#5
Pelin Arıcan, Berna Okudan Tekin, Seniha Naldöken, Rıza Şefizade, Dilek Berker
Von Hippel-Lindau syndrome (VHLS) is an autosomal dominant hereditary familial disorder characterized by development of malignant and benign neoplasms. Differential diagnosis of the adrenal and pancreatic masses are difficult in patients with VHLS. Iodine-123 metaiodobenzylguanidine (I-123 MIBG) and indium-111 somatostatin receptor scintigraphies (In-111 SRS) have important roles in the differential diagnosis of adrenal and pancreatic masses in those patients. In this case report, we present the findings of I-123 MIBG single-photon emission computerized tomography (SPECT/CT) and In-111 SRS SPECT/CT in three members of a family with VHLS...
February 5, 2017: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/28280363/discrimination-of-serous-cystadenoma-from-mucinous-cystadenoma-in-the-pancreas-with-contrast-enhanced-ultrasonography-a-prospective-study-in-61-patients
#6
Ya Sun, Fubo Zhou, Fangyi Liu, Yanyan Hu, Shuilian Tan, Ping Liang, Enqiang Linghu, Xiaoling Yu
OBJECTIVES: The preoperative diagnosis between serous cystadenomas (SCAs) and mucinous cystadenomas (MCAs) in pancreas is significant due to their completely different biological behaviors. The purpose of our study was to examine and compare detailed contrast-enhanced ultrasonography (CEUS) images of SCAs and MCAs and to determine whether there are significant findings that can contribute to the discrimination between these two diseases. METHODS: From April 2015 to June 2016, 61 patients (35 patients with SCAs and 26 patients with MCAs) were enrolled in this study...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28272682/xanthogranulomatous-pancreatitis-a-rare-case-defying-clinical-radiological-and-tumor-marker-diagnostics-with-a-review-of-literature
#7
Kavita Gaur, Shramana Mandal, Nidhi Mahajan, Sandeep Saluja, Satyajit Godhi
Xanthogranulomatous inflammation of the pancreas is an extremely rare entity mimicking pancreatic neoplasia. Elevation of tumor markers has seldom been reported in xanthogranulomatous inflammation of the pancreas, rendering the diagnosis difficult and highlighting the importance of a meticulous histopathological examination. A 58-year-old male presented with severe abdominal pain and anorexia for six months. A heterogeneously enhancing solid cystic mass was detected in the pancreatic head on contrast enhanced computed tomography...
February 4, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28267771/challenges-in-pancreatic-adenocarcinoma-surgery-national-survey-and-current-practice-guidelines
#8
Sameer A Dhayat, Philip Mirgorod, Christina Lenschow, Norbert Senninger, Christoph Anthoni, Thorsten Vowinkel
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) remains one of the most deadly cancers in Europe and the USA. There is consensus that radical tumor surgery is the only viable option for any long-term survival in patients with PDAC. So far, limited data are available regarding the routine surgical management of patients with advanced PDAC in the light of surgical guidelines. METHODS: A national survey on perioperative management of patients with PDAC and currently applied criteria on their tumor resectability in German university and community hospitals was carried out...
2017: PloS One
https://www.readbyqxmd.com/read/28266293/emergency-pancreatico-duodenectomy-with-superior-mesenteric-and-portal-vein-resection-and-reconstruction-using-a-gore-tex-vascular-graft
#9
Mihai Adrian Eftimie, Vasile Lungu, Marian Tudoroiu, Genady Vatachki, Severina Batca, Leonard David
Emergency pancreatico-duodenectomy(EPD) is a very rare procedure and few reports are present in medical literature. It is an uncommon approach, usually used for emergency surgical treatment of abdominal trauma that involves the head of the pancreas or the duodenum, but it is also a surgical tool for the treatment of ruptured aneurysms, bleeding pseudocysts, duodenal perforations, uncontrollable hemorrhage from ulcers and tumors, severe infectious complications of acute pancreatitis or endoscopic retrograde cholangiopancreatography related complications (1,2)...
January 2017: Chirurgia
https://www.readbyqxmd.com/read/28258440/comprehensive-characterization-of-genes-associated-with-the-tp53-signal-transduction-pathway-in-various-tumors
#10
Shumpei Ohnami, Keiichi Ohshima, Takeshi Nagashima, Kenichi Urakami, Yuji Shimoda, Junko Saito, Akane Naruoka, Keiichi Hatakeyama, Tohru Mochizuki, Masakuni Serizawa, Sumiko Ohnami, Masatoshi Kusuhara, Ken Yamaguchi
The TP53 signal transduction pathway is an attractive target for cancer treatments. In this study, we conducted a comprehensive molecular evaluation of 907 patients with cancer in Japan to identify genomic alterations in the TP53 pathway. TP53 mutations were frequently detected in many cancers, except melanoma, thymic tumors, gastrointestinal stromal tumors, and renal cancers. The frequencies of non-synonymous single nucleotide variants (SNVs) in the TP53 family members TP63 and TP73 were relatively low, although genes with increased frequencies of SNVs were as follows: PTEN (11...
March 3, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28248881/a-case-of-mixed-adenoneuroendocrine-carcinoma-of-the-pancreas-immunohistochemical-analysis-for-histogenesis
#11
Masaru Murata, Hidekazu Takahashi, Moyuru Yamada, Misa Song, Masahiro Hiratsuka
RATIONALE: Tumors with multiple histological features, such as adenocarcinomas and neuroendocrine carcinomas, were included as a new category of neuroendocrine carcinomas in the 2010 World Health Organization classification. We recently experienced a rare case of a pancreatic carcinoma with both adenocarcinoma and neuroendocrine carcinoma components, a so-called mixed adenoneuroendocrine carcinoma. PATIENT CONCERNS AND DIAGNOSIS: A 66-year-old man was referred to our hospital with obstructive jaundice...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28243118/the-different-functions-and-clinical-significances-of-caveolin-1-in-human-adenocarcinoma-and-squamous-cell-carcinoma
#12
REVIEW
Pin Fu, Fuchun Chen, Qi Pan, Xianda Zhao, Chen Zhao, William Chi-Shing Cho, Honglei Chen
Caveolin-1 (Cav-1), a major structural protein of caveolae, is an integral membrane protein which plays an important role in the progression of carcinoma. However, whether Cav-1 acts as a tumor promoter or a tumor suppressor still remains controversial. For example, the tumor-promoting function of Cav-1 has been found in renal cancer, prostate cancer, tongue squamous cell carcinoma (SCC), lung SCC and bladder SCC. In contrast, Cav-1 also plays an inhibitory role in esophagus adenocarcinoma, lung adenocarcinoma and cutaneous SCC...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28241470/pancreatic-exocrine-insufficiency-in-pancreatic-cancer
#13
REVIEW
Miroslav Vujasinovic, Roberto Valente, Marco Del Chiaro, Johan Permert, J-Matthias Löhr
Abstract: Cancer patients experience weight loss for a variety of reasons, commencing with the tumor's metabolism (Warburg effect) and proceeding via cachexia to loss of appetite. In pancreatic cancer, several other factors are involved, including a loss of appetite with a particular aversion to meat and the incapacity of the pancreatic gland to function normally when a tumor is present in the pancreatic head. Pancreatic exocrine insufficiency is characterized by a deficiency of the enzymes secreted from the pancreas due to the obstructive tumor, resulting in maldigestion...
February 23, 2017: Nutrients
https://www.readbyqxmd.com/read/28222111/a-meta-analysis-of-the-abscopal-effect-in-preclinical-models-is-the-biologically-effective-dose-a-relevant-physical-trigger
#14
Raffaella Marconi, Silvia Strolin, Gianluca Bossi, Lidia Strigari
BACKGROUND: Preclinical in vivo studies using small animals are considered crucial in translational cancer research and clinical implementation of novel treatments. This is of paramount relevance in radiobiology, especially for any technological developments permitted to deliver high doses in single or oligo-fractionated regimens, such as stereotactic ablative radiotherapy (SABR). In this context, clinical success in cancer treatment needs to be guaranteed, sparing normal tissue and preventing the potential spread of disease or local recurrence...
2017: PloS One
https://www.readbyqxmd.com/read/28205397/pancreatic-involvement-by-metastasizing-neoplasms-as-determined-by-endoscopic-ultrasound-guided-fine-needle-aspiration-a-clinicopathologic-characterization
#15
Miroslav Sekulic, Khalid Amin, Tetyana Mettler, Lizette K Miller, Shawn Mallery, Jimmie Stewart
BACKGROUND: Pancreatic tumors often represent primary neoplasms, however organ involvement with metastatic disease can occur. The use of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) to determine the underlying pathology provides guidance of clinical management. METHODS: 25 cases were identified in a retrospective review of our institution's records from 2006 to 2016. Clinical parameters and prognosis are described. RESULTS: Metastatic lesions to the pancreas diagnosed by EUS-FNA accounted for 4...
February 16, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28156605/the-requirement-of-fentanyl-patch-in-terminally-ill-patients-with-cancer
#16
Aya Watanabe, Hiroto Ishiki, Tsukuru Chiba, Junya Kinkawa, Chie Watanabe, Keisuke Ariyoshi, Masanori Nojima, Satoru Iwase, Arinobu Tojo
202 Background: Cancer pain is the most important problem to overcome in terminally ill cancer patients (TICPs). Recently, the fentanyl patch (FP) has been widely used for the treatment of cancer pain. However, the FP requirement largely varies in patients. The purpose of this study was to identify the determinants of the FP requirement in TICPs and propose effective pain relief using a FP. METHODS: In a retrospective chart review, we investigated cancer patients who were admitted in our hospital from April 2012 to July 2015 and used FP until their deaths...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28134698/68ga-exendin-4-pet-ct-in-evaluation-of-endoscopic-ultrasound-guided-ethanol-ablation-of-an-insulinoma
#17
Yaping Luo, Ji Li, Aiming Yang, Hongbo Yang, Fang Li
A 32-year-old man with endogenous hyperinsulinemic hypoglycemia was clinically diagnosed with an insulinoma. Conventional imaging result was negative, and a previous exploratory laparotomy with distal pancreatectomy failed to detect the tumor. Ga-exendin-4 PET/CT showed a lesion with intense radioactivity in the head of the pancreas suggestive of an insulinoma, and endoscopic ultrasound-guided ethanol ablation was performed. Postablation evaluation with Ga-exendin-4 PET/CT showed markedly decreased radioactivity of the tumor...
January 27, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28133320/-a-case-of-multiple-pancreatic-metastases-from-renal-cell-carcinoma-diagnosed-using-eus-fna
#18
Chikato Koga, Masahiro Murakami, Junzo Shimizu, Akinobu Yasuyama, Tae Matsumura, Chizu Kameda, Ryohei Kawabata, Naofumi Oda, Masaki Hirota, Masato Yoshikawa, Hirotaka Morishima, Shingo Noura, Nobuki Matsunami, Junichi Hasegawa
The patient was a 79-year-old man, who underwent left nephrectomy for left renal cell carcinoma in 2007. In March 2015, he complained ofthirst, polydipsia, and polyuria. A slight elevation ofamylase levels was detected following laboratory testing. Abdominal CT revealed well-enhanced tumors in the pancreatic head and tail. MPD was dilated in the pancreatic body and tail. Endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA)was used to obtain additional pathological findings. We diagnosed multiple pancreatic metastases from renal cell carcinoma using cell block sections from EUS-FNA ofthe pancreatic head tumor...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133317/-pancreatic-adenosquamous-carcinoma-that-developed-after-resection-of-ipma-in-the-pancreatic-tail
#19
Akinao Kaneta, Takao Tsuchiya, Takahiro Saito, Satoshi Otani, Fujio Ito, Junichi Miura
Pancreatic adenosquamous carcinoma coexisting with intraductal papillary mucinous neoplasm(IPMN)is extremely rare. We report a rare case of pancreatic adenosquamous carcinoma that developed after resection of intraductal papillary mucinous adenoma(IPMA). A 67-year-old man was suspected of having a pancreatic cystic lesion. MRCP demonstrated a cystic lesion measuring 25mm in the pancreatic tail, which had an enhanced nodule. We therefore diagnosed branch duct type IPMN of the pancreas. Although pancreatic juice cytology did not indicate malignancy, we performed laparoscope-assisted distal pancreatectomy...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133293/-a-case-of-pancreatic-metastasis-of-renal-cell-carcinoma
#20
Kouei Nihei, Kaoru Sakamoto, Satoshi Suzuki, Takeshi Mishina, Masahiro Otaki
A 69-year-old woman underwent right nephrectomy for the treatment of renal cell carcinoma. Nine years later, a 2 cm, solitary tumor was detected in the pancreas tail using computed tomography, and the patient underwent distal pancreatectomy and splenectomy. The pathological diagnosis was metastasis of renal cell carcinoma. A year later, a new tumor was confirmed in the pancreas head on a follow-upCT scan. Nine years after the resection of the pancreatic metastasis, the pancreas head tumor had increased in size...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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