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https://www.readbyqxmd.com/read/28428816/physical-health-policies-and-metabolic-screening-in-mental-health-care-systems-of-sub-saharan-african-countries-a-systematic-review
#1
REVIEW
James Mugisha, Marc De Hert, Brendon Stubbs, David Basangwa, Davy Vancampfort
BACKGROUND: There is a need for interventions to address the escalating mental health burden in sub-Saharan Africa (SSA). Addressing physical health needs should have a central role in reducing the burden and facilitating recovery in people with severe mental illness (SMI). We systematically investigated (1) physical health policies in the current mental health plans, and (2) the routine metabolic screening rates for people with SMI in SSA. METHODS: The Mental Health Atlas and MiNDbank of the World Health Organization were screened for physical health policies in mental health plans...
2017: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/28402587/methotraxate-loaded-hybrid-nanoconstructs-target-vascular-lesions-and-inhibit-atherosclerosis-progression-in-apoe-mice
#2
Cinzia Stigliano, Maricela R Ramirez, Jaykrishna V Singh, Santosh Aryal, Jaehong Key, Elvin Blanco, Paolo Decuzzi
Atherosclerosis is an inflammatory disorder characterized by the progressive thickening of blood vessel walls eventually resulting in acute vascular syndromes. Here, intravenously injectable hybrid nanoconstructs are synthesized for tempering immune cell inflammation locally and systemically. Lipid and polymer chains are nanoprecipitated to form 100 nm spherical polymeric nanoconstructs (SPNs), loaded with methotrexate (MTX) and subsequently labeled with Cu(64) and fluorescent probes for combined nuclear/optical imaging...
April 12, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28395951/prevalence-and-determinants-of-comorbid-diabetes-and-hypertension-evidence-from-non-communicable-disease-risk-factor-steps-survey-india
#3
Jaya Prasad Tripathy, J S Thakur, Gursimer Jeet, Sanjay Jain
PROBLEM STATEMENT: Comorbidity of non-communicable diseases carries a significant risk of cardiovascular events and mortality. With the rising burden of diabetes, hypertension and other risk factors, and ageing population in India, this is likely to pose a major threat to the health system. It is therefore essential to understand this high risk group. This article reports prevalence of comorbid diabetes and hypertension and its associated risk factors in the North Indian state of Punjab...
March 31, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28356880/cardiovascular-risk-factors-in-7-13-years-old-children-from-vojvodina-serbia
#4
Darko D Dželajlija, Slavica S Spasić, Jelena M Kotur-Stevuljevic, Nataša B Bogavac-Stanojevic
BACKGROUND: Atherosclerosis is a chronic inflammatory disease which starts early in life and depends on many factors, an important one being dyslipoproteinemia. According to several studies, atherosclerotic plaques or their precursors could be seen in children younger than 10 years. During later life, interaction with a sedentary way of life, as well as unhealthy nutrition, smoking, alcohol consumption, obesity and family history of cardiovascular disease cause the burden of atherosclerotic disease...
September 2016: Journal of Medical Biochemistry
https://www.readbyqxmd.com/read/28325541/the-relationship-between-diabetic-retinopathy-and-nephropathy-in-sudanese-adult-with-diabetes-population-based-study
#5
Mohamed H Ahmed, Einas S Elwali, Heitham Awadalla, Ahmed O Almobarak
INTRODUCTION: Diabetic nephropathy is responsible for nearly third of the world cases of end stage renal disease; it becomes a major public health problem with social and economic burden. The aim of this study is to explore if there is an association between retinopathy and nephropathy. MATERIAL AND METHODS: In a cross sectional hospital based study a total of 316 individuals with diabetes were recruited from Makkah eye complex retina clinic. Demographic data, medical history and life style characteristics were taken through standard questionnaire...
March 7, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28321254/does-good-aerobic-capacity-attenuate-the-effects-of-aging-on-cardiovascular-risk-factors-results-from-a-cross-sectional-study-in-a-latino-population
#6
Giovanna Valentino, Mónica Acevedo, Lorena Orellana, María José Bustamante, Verónica Kramer, Marcela Adasme, Fernando Baraona, Gastón Chamorro, Jorge Jalil, Carlos Navarrete
Background. High aerobic capacity is associated with low cardiovascular (CV) risk. The aim of this study was to determine the CV RF burden in subjects with aerobic capacity ≥10 METs and compare it with those having <10 METs. Methods. Cross-sectional study in 2646 subjects (mean age 48 ± 12 years). Demographics, medical history, physical activity, cardiovascular RFs, fasting lipids and blood glucose levels, blood pressure, and anthropometric measurements were collected. Aerobic capacity was determined by exercise stress test...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28320601/coronary-atherosclerosis-in-indigenous-south-american-tsimane-a-cross-sectional-cohort-study
#7
Hillard Kaplan, Randall C Thompson, Benjamin C Trumble, L Samuel Wann, Adel H Allam, Bret Beheim, Bruno Frohlich, M Linda Sutherland, James D Sutherland, Jonathan Stieglitz, Daniel Eid Rodriguez, David E Michalik, Chris J Rowan, Guido P Lombardi, Ram Bedi, Angela R Garcia, James K Min, Jagat Narula, Caleb E Finch, Michael Gurven, Gregory S Thomas
BACKGROUND: Conventional coronary artery disease risk factors might potentially explain at least 90% of the attributable risk of coronary artery disease. To better understand the association between the pre-industrial lifestyle and low prevalence of coronary artery disease risk factors, we examined the Tsimane, a Bolivian population living a subsistence lifestyle of hunting, gathering, fishing, and farming with few cardiovascular risk factors, but high infectious inflammatory burden. METHODS: We did a cross-sectional cohort study including all individuals who self-identified as Tsimane and who were aged 40 years or older...
March 16, 2017: Lancet
https://www.readbyqxmd.com/read/28283980/alleviating-the-environmental-heat-burden-on-laying-hens-by-feeding-on-diets-enriched-with-certain-antioxidants-vitamin-e-and-selenium-individually-or-combined
#8
Mohamed E Abd El-Hack, Khalid Mahrose, Muhammad Arif, Maria Tabassum Chaudhry, Islam M Saadeldin, Muhammad Saeed, Rab Nawaz Soomro, Imtiaz Hussain Raja Abbasi, Zaib Ur Rehman
The present study was designed to alleviate the negative biohazards of high ambient temperature on the productive performance and physiological status of laying hens. A total of 135 Bovans laying hens were distributed into nine groups in a 3 × 3 factorial design experiment. Basal diet was supplemented with vitamin E at levels of 0, 250, and 500 mg /kg diet. Within each dietary vitamin E level, each diet was supplemented with sodium selenite as a source of selenium (Se) to supply 0, 0.25, and 0.50 mg Se/kg diet...
March 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28263370/fixed-dose-combination-therapy-for-the-prevention-of-atherosclerotic-cardiovascular-diseases
#9
REVIEW
Ehete Bahiru, Angharad N de Cates, Matthew Rb Farr, Morag C Jarvis, Mohan Palla, Karen Rees, Shah Ebrahim, Mark D Huffman
BACKGROUND: Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of death and disability worldwide, yet ASCVD risk factor control and secondary prevention rates remain low. A fixed-dose combination of blood pressure- and cholesterol-lowering and antiplatelet treatments into a single pill, or polypill, has been proposed as one strategy to reduce the global burden of ASCVD. OBJECTIVES: To determine the effect of fixed-dose combination therapy on all-cause mortality, fatal and non-fatal ASCVD events, and adverse events...
March 6, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28228373/statins-and-fibrates-for-diabetic-retinopathy-protocol-for-a-systematic-review
#10
Vania Mozetic, Carolina Gomes Freitas, Rachel Riera
BACKGROUND: Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus, and more than 75% of patients who have had diabetes for more than 20 years will have some degree of DR. This disease is highly destructive to self-esteem and puts a high burden on public health and pension systems due to the effects that it has on people of working age. The current mainstay of treatment is laser photocoagulation, which causes impairment of vision and discomfort to patients...
February 22, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28225543/cuba-s-aging-and-alzheimer-longitudinal-study
#11
Juan de Jesús Llibre-Rodríguez, Adolfo Valhuerdi-Cepero, Ana M López-Medina, Lisseth Noriega-Fernández, Rutbeskia Porto-Álvarez, Milagros A Guerra-Hernández, Rodolfo I Bosch-Bayard, Tania Zayas-Llerena, Elaine Hernandez-Ulloa, Ana L Rodríguez-Blanco, Enrique Salazar-Pérez, Juan C Llibre-Guerra, Jorge J Llibre-Guerra, Beatriz Marcheco-Teruel
Aging and Alzheimer is a prospective, longitudinal cohort study involving 2944 adults aged ≥65 years from selected areas in Cuba's Havana and Matanzas Provinces. This door-to-door study, which began in 2003, includes periodic assessments of the cohort based on an interview; physical exam; anthropometric measurements; and diagnosis of dementia and its subtypes, other mental disorders, and other chronic non-communicable diseases and their risk factors. Information was gathered on sociodemographic characteristics; disability, dependency and frailty; use of health services; and characteristics of care and caregiver burden...
January 2017: MEDICC Review
https://www.readbyqxmd.com/read/28217505/noncommunicable-disease-in-rural-india-are-we-seriously-underestimating-the-risk-the-nallampatti-noncommunicable-disease-study
#12
Krishnan Swaminathan, Ganesh Veerasekar, Sujatha Kuppusamy, Mohanraj Sundaresan, Ganesan Velmurugan, Nalla G Palaniswami
AIM: To assess the prevalence of noncommunicable diseases in a true rural farming population in South India and compare the data with the landmark contemporary Indian Council of Medical Research-India Diabetes (ICMR-INDIAB) study. METHODS: Local Ethics Committee approval and informed consent was obtained from all participants. Inclusion criteria were participants, aged ≥20 and ≤85 years, from Nallampatti, a classical farming village from Tamil Nadu state, India...
January 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28127468/burden-of-hypertension-in-the-capital-of-afghanistan-a-cross-sectional-study-in-kabul-city-2015
#13
Khwaja Mir Islam Saeed
Background. This study had the objective to assess the prevalence and associated factors of hypertension in an urban setting, Kabul city, Afghanistan. Materials and Methods. The World Health Organization's STEP-wise approach was adopted and used in Kabul in November 2015. The study analyzed a sample of 1172 adults in the age group of 25-70 years. Demographic, socioeconomic, and behavior data were collected using a structured questionnaire. Fasting venous blood sample was collected to assess the lipid profile and fasting blood sugar...
2017: International Journal of Hypertension
https://www.readbyqxmd.com/read/28057507/association-between-thyroid-hormone-parameters-and-dyslipidemia-among-type-2-diabetes-mellitus-patients-comparative-cross-sectional-study
#14
Amare Desalegn Wolide, Belay Zawdie, Tilahun Alemayehu, Samuel Tadesse
BACKGROUND: The relationship between thyroid function and lipid profile has been documented in T2DM and healthy subjects. The aim of the current study was to assess the association between thyroid hormone parameters and dyslipidemia in T2DM and non-diabetic study participants. METHOD AND MATERIALS: In this comparative cross-sectional study, 214 type 2 diabetic and 214 non-diabetic study participants were enrolled. Clinical and anthropometric data were collected from all study participants...
December 26, 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28055017/rny-yrna-derived-small-rnas-regulate-cell-death-and-inflammation-in-monocytes-macrophages
#15
Zoheir Hizir, Silvia Bottini, Valerie Grandjean, Michele Trabucchi, Emanuela Repetto
The recent discovery of new classes of small RNAs has opened unknown territories to explore new regulations of physiopathological events. We have recently demonstrated that RNY (or Y RNA)-derived small RNAs (referred to as s-RNYs) are an independent class of clinical biomarkers to detect coronary artery lesions and are associated with atherosclerosis burden. Here, we have studied the role of s-RNYs in human and mouse monocytes/macrophages and have shown that in lipid-laden monocytes/macrophages s-RNY expression is timely correlated to the activation of both NF-κB and caspase 3-dependent cell death pathways...
January 5, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28049433/comparison-of-gene-expression-response-to-neutron-and-x-ray-irradiation-using-mouse-blood
#16
Constantinos G Broustas, Yanping Xu, Andrew D Harken, Guy Garty, Sally A Amundson
BACKGROUND: In the event of an improvised nuclear device detonation, the prompt radiation exposure would consist of photons plus a neutron component that would contribute to the total dose. As neutrons cause more complex and difficult to repair damage to cells that would result in a more severe health burden to affected individuals, it is paramount to be able to estimate the contribution of neutrons to an estimated dose, to provide information for those making treatment decisions. RESULTS: Mice exposed to either 0...
January 3, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28044466/brief-communication-plasma-lipid-oxidation-predicts-atherosclerotic-status-better-than-cholesterol-in-diabetic-apolipoprotein-e-deficient-mice
#17
Karen Ekkelund Petersen, Jens Lykkesfeldt, Kirsten Raun, Günaj Rakipovski
Increased levels of oxidative stress have been suggested to play a detrimental role in the development of diabetes-related vascular complications. Here, we investigated whether the concentration of malondialdehyde, a marker of lipid oxidation correlated to the degree of aortic plaque lesions in a proatherogenic diabetic mouse model. Three groups of apolipoprotein E knockout mice were studied for 20 weeks, a control, a streptozotocin-induced diabetic, and a diabetic enalapril-treated group. Enalapril was hypothesized to lower oxidative stress level and thus the plaque burden...
January 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28011231/metabolic-syndrome-and-occupation-any-association-prevalence-among-auto-technicians-and-school-teachers-in-south-west-nigeria
#18
Adeseye A Akintunde, Taiwo W Oloyede
AIMS: To determine occupational association with metabolic syndrome among auto technicians and school teachers. METHODS: One hundred and sixty six subjects were selected for this study. Clinical data was obtained while laboratory investigations including plasma glucose and lipid profile were performed. Statistical analysis was done with SPSS 20.0. P<0.05 was taken as statistically significant. RESULTS: School teachers had significantly higher mean total cholesterol and LDL-cholesterol compared to auto technicians...
December 14, 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28004792/nod2-dependent-neutrophil-recruitment-is-required-for-early-protective-immune-responses-against-infectious-litomosoides-sigmodontis-l3-larvae
#19
Jesuthas Ajendra, Sabine Specht, Sebastian Ziewer, Andrea Schiefer, Kenneth Pfarr, Marijo Parčina, Thomas A Kufer, Achim Hoerauf, Marc P Hübner
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) recognizes muramyl dipeptide (MDP) of bacterial cell walls, triggering NFκB-induced pro-inflammation. As most human pathogenic filariae contain Wolbachia endobacteria that synthesize the MDP-containing cell wall precursor lipid II, NOD2's role during infection with the rodent filaria Litomosoides sigmodontis was investigated. In NFκB reporter-cells, worm-extract containing Wolbachia induced NOD2 and NOD1. NOD2-deficient mice infected with L...
December 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27998159/relationship-between-cystatin-c-retinol-binding-protein-4-and-framingham-risk-score-in-healthy-postmenopausal-women
#20
Aleksandra Klisic, Jelena Kotur-Stevuljevic, Nebojsa Kavaric, Marija Matic
BACKGROUND: We aimed to examine the relationship between high levels of cystatin C, retinol-binding protein 4 (RBP4) and cardiovascular risk score [determined by Framingham Risk Score (FRS)] in postmenopausal women. METHODS: A total of apparently healthy 129 postmenopausal women (mean age 57.1 ± 4.6 years) were included. Serum cystatin C, RBP4, glucose, lipid parameters, creatinine, uric acid and high sensitivity C-reactive protein (hsCRP) were determined. Anthropometric parameters and blood pressure were also obtained...
December 2016: Archives of Iranian Medicine
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