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https://www.readbyqxmd.com/read/29665456/the-contribution-of-obesity-to-carotid-atherosclerotic-plaque-burden-in-a-general-population-sample-in-norway-the-troms%C3%A3-study
#1
Yume Imahori, Ellisiv B Mathiesen, David A Leon, Laila A Hopstock, Alun D Hughes, Stein Harald Johnsen, Lone Jørgensen, Nina Emaus, Katy E Morgan
BACKGROUND AND AIMS: Few studies have investigated the association of different measures of adiposity with carotid plaque. We aimed to investigate and compare the associations of four measures of adiposity: body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR) with the presence of carotid plaque and total plaque area (TPA) in the right carotid artery. METHODS: We included 4906 individuals aged 31-88 years who participated in a population-based study with ultrasonography of the right carotid artery...
April 12, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29661561/clinically-actionable-hypercholesterolemia-and-hypertriglyceridemia-in-children-with-nonalcoholic-fatty-liver-disease
#2
Kathryn E Harlow, Jonathan A Africa, Alan Wells, Patricia H Belt, Cynthia A Behling, Ajay K Jain, Jean P Molleston, Kimberly P Newton, Philip Rosenthal, Miriam B Vos, Stavra A Xanthakos, Joel E Lavine, Jeffrey B Schwimmer
OBJECTIVE: To determine the percentage of children with nonalcoholic fatty liver disease (NAFLD) in whom intervention for low-density lipoprotein cholesterol or triglycerides was indicated based on National Heart, Lung, and Blood Institute guidelines. STUDY DESIGN: This multicenter, longitudinal cohort study included children with NAFLD enrolled in the National Institute of Diabetes and Digestive and Kidney Diseases Nonalcoholic Steatohepatitis Clinical Research Network...
April 13, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29618598/routine-assessment-and-promotion-of-physical-activity-in-healthcare-settings-a-scientific-statement-from-the-american-heart-association
#3
REVIEW
Felipe Lobelo, Deborah Rohm Young, Robert Sallis, Michael D Garber, Sandra A Billinger, John Duperly, Adrian Hutber, Russell R Pate, Randal J Thomas, Michael E Widlansky, Michael V McConnell, Elizabeth A Joy
Physical inactivity is one of the most prevalent major health risk factors, with 8 in 10 US adults not meeting aerobic and muscle-strengthening guidelines, and is associated with a high burden of cardiovascular disease. Improving and maintaining recommended levels of physical activity leads to reductions in metabolic, hemodynamic, functional, body composition, and epigenetic risk factors for noncommunicable chronic diseases. Physical activity also has a significant role, in many cases comparable or superior to drug interventions, in the prevention and management of >40 conditions such as diabetes mellitus, cancer, cardiovascular disease, obesity, depression, Alzheimer disease, and arthritis...
April 4, 2018: Circulation
https://www.readbyqxmd.com/read/29606261/prognosis-and-treatment-of-diabetic-nephropathy-recent-advances-and-perspectives
#4
Peter Rossing, Frederik Persson, Marie Frimodt-Møller
Approximately 20 to 40% of patients with type 1 or type 2 diabetes develop diabetic kidney disease. It is a clinical syndrome characterized by persistent albuminuria (>300mg/24h, or 300mg/g creatinine), a relentless decline in glomerular filtration rate, raised arterial blood pressure and enhanced cardiovascular morbidity and mortality. The natural course of classical diabetic nephropathy is initially microalbuminuria or moderately increased urine albumin excretion (30-300mg/g creatinine). Untreated microalbuminuria may then rise gradually, reaching severely increased albuminuric (macroalbuminuria) over 5 to 15 years...
April 2018: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29594908/hematological-indicators-in-pygmy-wood-mouse-apodemus-uralensis-muridae-rodentia-populations-as-markers-of-the-environmental-radiation-exposure-east-urals-radioactive-trace-russia
#5
Natal'ya A Orekhova
The hematological effects of chronic radiation exposure in males of the pygmy wood mouse (Apodemus uralensis Pall., 1811) from the East Urals radioactive trace (EURT) area were assessed, taking into account population abundance and reproductive status (immature, ripening, and mature yearlings). For this purpose, we analyzed the morpho-functional characteristics of erythrocytes (red cell indices [MCV, MCH, MCHC], red cell count, activity of antioxidant enzymes [GSH-Px, CAT], lipid peroxidation, glycolysis, osmotic resistance, methaemoglobin content) and blood plasma components (free hemoglobin, total lipids, total cholesterol, and glucose) in the background territory and the EURT area; these areas have a density of soil contamination with90 Sr of 12,851 and 198 kBq × m-2 , respectively (four and two order of magnitude higher than the background value)...
March 29, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29576973/gender-disparities-in-the-association-between-socio-demographics-and-non-communicable-disease-risk-factors-among-adults-with-disabilities-in-shanghai-china
#6
Youran Zhang, Gang Chen, Qi Zhang, Jun Lu, Huijiong Yu
Background: Non-communicable disease (NCD) risk factors can co-exist with disability and cause a greater burden on the health status of adults with disabilities. A lack of egalitarian social policies in China may result in gender disparities in the NCD risk factors of adults with disabilities. However, little is known about the gender disparities in the association between socio-demographics and NCD risk factors among adults with disabilities in China; consequently, we examined this association among adults with disabilities in Shanghai, China...
2018: PeerJ
https://www.readbyqxmd.com/read/29575002/a-defined-plant-based-diet-utilized-in-an-outpatient-cardiovascular-clinic-effectively-treats-hypercholesterolemia-and-hypertension-and-reduces-medications
#7
Rami S Najjar, Carolyn E Moore, Baxter D Montgomery
BACKGROUND: Cardiovascular disease (CVD) is a major economic burden in the United States. CVD risk factors, particularly hypertension and hypercholesterolemia, are typically treated with drug therapy. Five-year efficacy of such drugs to prevent CVD is estimated to be 5%. Plant-based diets have emerged as effective mitigators of these risk factors. HYPOTHESIS: The implementation of a defined, plant-based diet for 4 weeks in an outpatient clinical setting may mitigate CVD risk factors and reduce patient drug burden...
March 25, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29569337/diabetes-cardiovascular-disorders-and-2-3-7-8-tcdd-body-burden-in-czech-patients-50-years-after-the-intoxication
#8
Tomas Pelcl, Jan Skrha, Martin Prazny, Stepanka Vlckova, Zdenka Fenclova, Tomas Navratil, Jan Malik, Pavel Diblik, Vit Zikan, Daniela Pelclova
The correlation between 2,3,7,8-tetrachlordibenzo-p-dioxin (TCDD) intoxication and the parameters of metabolic impairment were examined in the last 8 male survivors out of 80 workers exposed to TCDD during the production of herbicides in a chemical factory in 1965-1967. Their median TCDD blood level was 112 (46-390) pg/g lipids and the median TCDD body deposit was 3.9 (0.8-11.7) μg. This puts these patients into the most severely intoxicated group of subjects, according to back-calculated levels of TCDD. The median TCDD blood level in 8 controls was 12 pg/g (<0...
March 22, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29561733/cardiovascular-risk-factors-in-a-roma-sample-population-from-romania
#9
Emma Weiss, Cristina Japie, Ana Maria Balahura, Daniela Bartos, Elisabeta Badila
BACKGROUND: The Roma population has a high prevalence of cardiovascular risk factors, higher mortality, and shorter life expectancy. It is found in largest numbers in Romania, but published data are still scarce here. We studied cardiovascular risk factors and disease along with target organ damage on a population of Roma inhabitants from Bucharest, Romania. METHODS: This cross-sectional study enrolled, in a community-based participatory research manner, 806 Roma subjects (18-83 years)...
March 19, 2018: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/29553996/poststatin-era-in-atherosclerosis-management-lessons-from-epidemiologic-and-genetic-studies
#10
Laurent Yvan-Charvet, Bertrand Cariou
PURPOSE OF REVIEW: Cardiovascular diseases (CVD) are the leading cause of death worldwide with over 17 million deaths every year and represent a major public health challenge. The last decade has seen the emergence of novel antiatherogenic therapies. RECENT FINDINGS: Despite intensive lipid and blood pressure interventions, the burden of CVD is expected to markedly progress because of the global aging of the population and increasing exposure to detrimental lifestyle-related risk...
March 16, 2018: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/29535705/immune-mediated-inflammation-promotes-subclinical-atherosclerosis-in-recent-onset-psoriatic-arthritis-patients-without-conventional-cardiovascular-risk-factors
#11
Rodolfo A Kolliker Frers, Vanesa Cosentino, Julia Tau, Eduardo M Kerzberg, Adriana Urdapilleta, Monica Chiocconi, Nora Kogan, Matilde Otero-Losada, Francisco Capani
Studies on the inflammatory burden in recent-onset psoriatic arthritis (PsA) patients without conventional cardiovascular risk factors (CVRFs) are not available. This preliminary study focuses on cardiovascular risk in cutaneous psoriasis (CPs) and recent-onset PsA patients. Blood biochemistry (glucose, cholesterol, uric acid, lipid profile and apolipoprotein B) was analyzed using standard kits. Proatherogenic inflammation markers, C-reactive protein (CRP) and interleukin-6 (IL-6), and endothelial activators monocyte chemoattractant protein-1 (MCP-1) and soluble intercellular adhesion molecule-1 (sICAM-1), were determined by enzyme-linked immunosorbent assay...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29524682/cadmium-treatment-induces-echinocytosis-dna-damage-inflammation-and-apoptosis-in-cardiac-tissue-of-albino-wistar-rats
#12
Kavisa Ghosh, Indra N
Cadmium (Cd), a potent carcinogen present in almost all foods, poses a major health risk to humans. Major routes of exposure to Cd for humans are occupation, diet, and tobacco use. Cd elicits various deleterious effects on cellular molecules mainly by causing oxidant-antioxidant imbalance. Cd has been implicated in the pathogenesis of many cancers, Itai-itai disease, diabetic nephropathy, hypertension, peripheral artery disease, and myocardial infarction. This study was designed to investigate the effects of Cd intake on erythrocytes and cardiac tissue in male albino Wistar rats...
February 27, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29518416/allergen-induced-activation-of-nk-cells-represents-an-early-life-immune-response-in-development-of-allergic-asthma
#13
Matthew C Altman, Elizabeth Whalen, Alkis Togias, George T O'Connor, Leonard B Bacharier, Gordon R Bloomberg, Meyer Kattan, Robert A Wood, Scott Presnell, Petra LeBeau, Katy Jaffee, Cynthia M Visness, William W Busse, James E Gern
BACKGROUND: Childhood asthma in inner city populations is a major public health burden and understanding early life immune mechanisms that promote asthma onset is key to disease prevention. Children who develop asthma demonstrate a high prevalence of aeroallergen sensitization and T helper 2 (Th2)-type inflammation, however the early life immune events that lead to Th2 skewing and disease development are unknown. OBJECTIVE: We sought to use RNA sequencing of peripheral blood mononuclear cells (PBMCs) collected at age 2 to determine networks of immune responses that occur in children who develop allergy and asthma...
March 5, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29500121/cardiovascular-and-renal-burdens-of-prediabetes-in-the-usa-analysis-of-data-from-serial-cross-sectional-surveys-1988-2014
#14
Mohammed K Ali, Kai McKeever Bullard, Sharon Saydah, Giuseppina Imperatore, Edward W Gregg
BACKGROUND: There is controversy over the usefulness of prediabetes as a diagnostic label. Using data from US National Health and Nutrition Examination Surveys (NHANES) between 1988 and 2014, we examined the cardiovascular and renal burdens in adults with prediabetes over time and compared patterns with other glycaemic status groups. METHODS: We analysed cross-sectional survey data from non-pregnant adults aged 20 years and older from the NHANES survey periods 1988-94, 1999-2004, 2005-10, and 2011-14...
February 27, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29478187/efficacy-and-safety-of-american-ginseng-panax-quinquefolius-l-extract-on-glycemic-control-and-cardiovascular-risk-factors-in-individuals-with-type-2-diabetes-a-double-blind-randomized-cross-over-clinical-trial
#15
Vladimir Vuksan, Zenith Zheng Xu, Elena Jovanovski, Alexandra L Jenkins, Uljana Beljan-Zdravkovic, John L Sievenpiper, P Mark Stavro, Andreea Zurbau, Lea Duvnjak, Michael Z C Li
PURPOSE: Despite the lack of evidence, a growing number of people are using herbal medicine to attenuate the burden of diabetes. There is an urgent need to investigate the clinical potential of herbs. Preliminary observations suggest that American ginseng (Panax quinquefolius [AG]) may reduce postprandial glycemia. Thus, we aimed to evaluate the efficacy and safety of AG as an add-on therapy in individuals with type 2 diabetes (T2DM) controlled by conventional treatment. METHODS: 24 individuals living with T2DM completed the study (F:M = 11:13; age = 64 ± 7 year; BMI = 27...
February 24, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29473759/contribution-of-non-traditional-lipid-profiles-to-reduced-glomerular-filtration-rate-in-h-type-hypertension-population-of-rural-china
#16
Haoyu Wang, Zhao Li, Xiaofan Guo, Yintao Chen, Shuang Chen, Yichen Tian, Yingxian Sun
BACKGROUND: Despite current interest in the unfavourable impact of non-traditional lipid profiles on cardiovascular disease, information regarding its relations to reduced glomerular filtration rate (GFR) in H-type hypertension population has not been systemically elucidated. METHODS: Analyses were based upon a cross-sectional study of 3259 participants with H-type hypertension who underwent assessment of biochemical, anthropometric and blood pressure values. Reduced GFR was considered if meeting estimated GFR <60 ml/min/1...
May 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29449808/suppressive-effects-of-clerodendrum-volubile-p-beauv-labiatae-methanolic-extract-and-its-fractions-on-type-2-diabetes-and-its-complications
#17
Ochuko L Erukainure, Rahman M Hafizur, Nurul Kabir, M Iqbal Choudhary, Olubunmi Atolani, Priyanka Banerjee, Robert Preissner, Chika I Chukwuma, Aliyu Muhammad, Eric O Amonsou, Md Shahidul Islam
Type 2 diabetes is the most prominent of all diabetes types, contributing to global morbidity and mortality. Availability and cost of treatment with little or no side effect especially in developing countries, remains a huge burden. This has led to the search of affordable alternative therapies especially from medicinal plants. In this study, the antidiabetic effect of the methanolic extract, dichloromethane (DCM), butanol (BuOH) and aqueous fractions of Clerodendrum volubile leaves were investigated in type 2 diabetic rats for their effect on glucose homeostasis, serum insulin level and hepatic biomarkers, lipid profile, pancreatic redox balance and Ca 2+ levels, and β-cell distribution and function...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29432601/surf-copd-the-recording-of-cardiovascular-risk-in-patients-with-chronic-lung-disease
#18
A Dudina, S Lane, M Butler, M-T Cooney, I Graham
Background: Cardiovascular disease (CVD) is the leading cause of death in patients with chronic obstructive pulmonary disease (COPD) and such patients tend to carry a heavy burden of risk factors for CVD. There is little information on the documentation and management of CVD risk factors in COPD patients. Aim: To audit the recording and management of CVD risk factors in 200 COPD patients attending the respiratory out-patient clinics at two University teaching hospitals...
February 8, 2018: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29417017/how-much-do-persons-with-diabetes-in-a-rural-area-of-south-india-know-about-diabetes-management-a-step-toward-person-centered-care
#19
Marie Gilbert Majella, Palanivel Chinnakali, Bijay Nanda Naik, Pruthu Thekkur, Bharath Nag, Gomathi Ramaswamy
Introduction: The burden of diabetes mellitus is increasing worldwide, more so in developing countries. Optimal diabetes care depends on adherence to management protocol, which can be brought about by shared decision-making. Patient's knowledge on life-threatening complications and preventive strategies for the same is a prerequisite for shared decision-making. Hence, this study was carried out among diabetes patients to assess the level of knowledge on different aspects of diabetes management...
July 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29407079/identification-risk-assessment-and-management-of-patients-with-atrial-fibrillation-in-a-large-primary-care-cohort
#20
Katrina K Poppe, Robert N Doughty, Matire Harwood, P Alan Barber, Jeff Harrison, Rod Jackson, Sue Wells
BACKGROUND: Atrial fibrillation (AF) is associated with increased risk of cardiovascular disease (CVD) complications including stroke. We investigated the assessment and management of cardiovascular risk among patients with AF aged 35-74years, by ethnic group, in a large cohort of people receiving a CVD risk assessment in primary care (PREDICT). METHODS: PREDICT was linked to national dispensing, hospitalisation and mortality records. AF was present if recorded in PREDICT or during a prior hospitalisation; medications were those dispensed ≤6months before or after a PREDICT assessment; the CHA 2 DS 2 -VASc score and a New Zealand (NZ) adjusted Framingham CVD risk were calculated...
March 1, 2018: International Journal of Cardiology
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