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https://www.readbyqxmd.com/read/29320364/cardiometabolic-effects-of-psychotropic-medications
#1
REVIEW
Oluchi Abosi, Sneha Lopes, Samantha Schmitz, Jess G Fiedorowicz
Background Many psychiatric disorders including schizophrenia, bipolar disorder and major depression convey an excess burden of cardiovascular morbidity and mortality. The medications used to treat these conditions may further adversely affect cardiovascular risk and exacerbate health disparities for vulnerable populations. There is a clinical need to appreciate the cardiometabolic adverse effects of psychotropic medications. Methods This paper reviews the most relevant cardiometabolic effects of psychotropic medications, organized around the components of metabolic syndrome...
January 10, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29284990/the-impact-of-risk-factors-and-comorbidities-on-the-incidence-of-atrial-fibrillation
#2
Nabil Naser, Mirza Dilic, Azra Durak, Mehmed Kulic, Esad Pepic, Elnur Smajic, Zumreta Kusljugic
Introduction: Atrial fibrillation (AF) is the most common form of cardiac arrhythmia in clinical practice and its prevalence increases with age. Patients who develop AF also have cardiovascular risk factors, structural heart disease, and comorbidities, all of which can increase mortality. AF causes a significant economic burden with the increasing trend in AF prevalence and hospitalizations. Research Objectives: The objective of our study is to evaluate the impact of the most common known risk factors on the incidence of atrial fibrillation as an important precursor of cardiac and cerebrovascular morbidity and mortality among our patients in Bosnia and Herzegovina during median follow up period (September 2006 - September 2016)...
December 2017: Materia Socio-medica
https://www.readbyqxmd.com/read/29279270/prevalence-of-thyroid-disorders-in-north-indian-type-2-diabetic-subjects-a-cross-sectional-study
#3
Maaz Ozair, Saba Noor, Alok Raghav, Sheelu Shafiq Siddiqi, Anjum Mirza Chugtai, Jamal Ahmad
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a major health burden worldwide with many patients encountering thyroid dysfunction later in their life. Various studies have found that diabetes and thyroid disorders mutually influence each other and both disorders tend to coexists. However, the prevalence of thyroid dysfunction and associated clinical variables in these patients has not been investigated. OBJECTIVES: The study aimed at determining the incidence and prevalence of thyroid dysfunction in patients with T2DM in relation to age, sex, metabolic syndrome and other co-morbid conditions...
December 20, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29276176/coronary-aneurysms-in-the-acute-patient-incidence-characterization-and-long-term-management-results
#4
Iván J Núñez-Gil, Belén Terol, Gisela Feltes, Luis Nombela-Franco, Pablo Salinas, Javier Escaned, Pilar Jiménez-Quevedo, Nieves Gonzalo, David Vivas, Daniel Bautista, Carlos Macaya, Antonio Fernández-Ortiz
BACKGROUND: Coronary aneurysms (1.5 times dilation the reference-vessel) are uncommon and have been diagnosed with increasing frequency with coronary angiography. The incidence varies from 1.5% to 5%. Reported complications are multiple: thrombosis, distal embolization, rupture and vasospasm, causing ischemia, heart failure or arrhythmias. However, the natural history and prognosis remains obscure. We aimed to describe the characteristics of acute patients with coronary aneurysms. METHODS: Prospective coronariography registry of patients with the diagnosis of coronary aneurysm between 2002 and 2013...
December 6, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29262289/excess-clinical-comorbidity-among-hiv-infected-patients-accessing-primary-care-in-us-community-health-centers
#5
Kenneth H Mayer, Stephanie Loo, Phillip M Crawford, Heidi M Crane, Michael Leo, Paul DenOuden, Magda Houlberg, Mark Schmidt, Thu Quach, Sebastian Ruhs, Meredith Vandermeer, Chris Grasso, Mary Ann McBurnie
OBJECTIVES: As the life expectancy of people infected with human immunodeficiency virus (HIV) infection has increased, the spectrum of illness has evolved. We evaluated whether people living with HIV accessing primary care in US community health centers had higher morbidity compared with HIV-uninfected patients receiving care at the same sites. METHODS: We compared data from electronic health records for 12 837 HIV-infected and 227 012 HIV-uninfected patients to evaluate the relative prevalence of diabetes mellitus, hypertension, chronic kidney disease, dyslipidemia, and malignancies by HIV serostatus...
January 1, 2017: Public Health Reports
https://www.readbyqxmd.com/read/29246427/diverging-patterns-of-cardiovascular-diseases-across-immigrant-groups-in-northern-italy
#6
Ugo Fedeli, Francesco Avossa, Eliana Ferroni, Elena Schievano, Claudio Bilato, Pietro Amedeo Modesti, Maria Chiara Corti
BACKGROUND: Only fragmentary data are available on the burden of non-communicable diseases among immigrants in Europe, mostly limited to mortality by cause. Aim of the study is to investigate the prevalence of cardiovascular diseases across different immigrant groups in the Veneto Region (North-Eastern Italy). METHODS: The resident population aged 20-59 was classified according to country of citizenship. The Adjusted Clinical Groups System was adopted to identify selected cardiovascular conditions by linkage of Hospital Discharge Records, Emergency Room visits, Chronic disease registry for copayment exemptions, the Home care database, and drugs reimbursed by the Regional Health Service...
December 8, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29226690/low-levels-of-endothelial-progenitor-cells-and-their-association-with-systemic-inflammation-and-monocyte-activation-in-older-hiv-infected-men
#7
Sophie Seang, Theodoros Kelesidis, Diana Huynh, Sangeun Park, Ardis Moe, Judith Currier, Jordan E Lake
BACKGROUND: Endothelial progenitor cells (EPCs) repair damaged vascular endothelium and low circulating EPC levels have been associated with cardiovascular disease (CVD). CD34+/KDR+ EPCs are commonly reported in literature and CD34+/CD133+/KDR+ EPCs are rare in circulation but highly specific for endothelial lineage. HIV-infected (HIV+) adults have chronic inflammation and increased CVD risk, but the relationship between CVD, vascular inflammation and EPCs in HIV remains unclear. METHODS: In a pilot study, EPCs were measured in 57 HIV+ men (≧50 years old, HIV-1 RNA <50 copies/mL on ART) by real-time flow cytometry using cellular immaturity (CD34 and/or CD133) and endothelial commitment (KDR) markers...
December 10, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29209476/osteoarthritis-affects-health-related-quality-of-life-in-korean-adults-with-chronic-diseases-the-korea-national-health-and-nutritional-examination-surveys-2009-2013
#8
Ji Hye Yang, Kiheon Lee, Se Young Jung, Woo Kyung Bae, Hye Jin Ju, In Young Cho, Jae Kyeong Song, Hwa Yeon Park, Jong-Soo Han, Ga-Hye Lee, Ye Seul Bae
Background: Osteoarthritis (OA) is a chronic disease that commonly afflicts the elderly. This disease reduces the health-related quality of life (HRQoL) and causes a significant social burden. Whether the effect of coexisting chronic conditions on HRQoL varies according to the presence of OA remains unclear. Therefore, this study aimed to investigate this notion. Methods: A total of 13,395 participants were identified from the 2009-2013 Korean National Health and Nutrition Examination Survey for analysis...
November 2017: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/29199410/non-alcoholic-fatty-liver-disease-the-emerging-burden-in-cardiometabolic-and-renal-diseases
#9
REVIEW
Eugene Han, Yong Ho Lee
As the number of individuals with non-alcoholic fatty liver disease (NAFLD) has increased, the influence of NAFLD on other metabolic diseases has been highlighted. Accumulating epidemiologic evidence indicates that NAFLD not only affects the liver but also increases the risk of extra-hepatic diseases such as type 2 diabetes mellitus, metabolic syndrome, dyslipidemia, hypertension, cardiovascular or cerebrovascular diseases, and chronic kidney disease. Non-alcoholic steatohepatitis, an advanced type of NAFLD, can aggravate these inter-organ relationships and lead to poorer outcomes...
November 17, 2017: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/29161075/metabolic-dysregulation-systemic-inflammation-and-pediatric-obesity-related-asthma
#10
Deepa Rastogi, Fernando Holguin
Obesity-related asthma is a distinct pediatric asthma phenotype. It is associated with higher disease burden, lower pulmonary function, and suboptimal response to current asthma medications. Recent studies have made inroads into elucidating its pathophysiology. Systemic immune responses in obese children with asthma are skewed to a nonatopic T-helper cell type 1 (Th1) pattern that correlates with pulmonary function deficits. The prevalence of metabolic dysregulation is also higher among obese children with asthma than among normal-weight children with asthma...
November 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29150492/predictors-of-mortality-in-patients-with-severe-ischemic-cardiomyopathy-undergoing-surgical-mitral-valve-intervention
#11
Kenya Kusunose, Nancy A Obuchowski, Marc Gillinov, Zoran B Popovic, Scott D Flamm, Brian P Griffin, Deborah H Kwon
BACKGROUND: Ischemic mitral regurgitation is associated with substantial risk of death. Although surgical mitral valve intervention (MVi) may improve symptoms, it has not been shown to improve survival. The aim of this study was to identify predictors of mortality in patients with ischemic mitral regurgitation and MVi. METHODS AND RESULTS: We evaluated 117 consecutive patients (age, 65±10 years) with advanced ischemic cardiomyopathy who underwent cardiac magnetic resonance and subsequent MVi between January 1, 2002 and January 1, 2012...
November 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29130000/knowledge-of-stroke-risk-factors-and-warning-signs-in-patients-with-recurrent-stroke-or-recurrent-transient-ischaemic-attack-in-thailand
#12
Jittima Saengsuwan, Pathitta Suangpho, Somsak Tiamkao
Stroke is a global burden. It is not known whether patients who are most at risk of stroke (recurrent stroke or recurrent transient ischaemic attack) have enough knowledge of stroke risk factors and warning signs. The aim of this study was to assess the knowledge of stroke risk factors and warning signs in this high-risk population. We performed a cross-sectional questionnaire-based study of patients with recurrent stroke or recurrent TIA admitted to Srinagarind Hospital and Khon Kaen Hospital, Thailand. A total of 140 patients were included in the study (age 65...
2017: Neurology Research International
https://www.readbyqxmd.com/read/29129602/standardized-fraction-of-xylocarpus-moluccensis-fruits-improve-vascular-relaxation-and-plaque-stability-in-dyslipidemic-models-of-atherosclerosis
#13
Jitendra S Kanshana, Sanjay C Rebello, Priya Pathak, Babu Nageswararao Kanuri, Hobby Aggarwal, Vasundhara Srivastava, Vivek Khanna, Vishal Singh, Kumaravelu Jagavelu, Manoj K Barthwal, Madhu Dikshit
ETHNOPHARMACOLOGICAL RELEVANCE: Xylocarpus moluccensis (Lamk.) M. Roem of family Meliaceae has triterpenoids rich fruits. Triterpenoids have been known to possess cardioprotection and anti-atherosclerotic activities (Han and Bakovic, 2015; Wu et al., 2009). Standardized fraction of these fruits exhibited anti-dyslipidemic (Srivastava et al., 2015), anti-inflammatory (Ravangpai et al., 2011) and CNS depressant activity (Sarker et al., 2007). However, there is no report in the literature on its cardiovascular effects...
November 10, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29077762/awareness-treatment-and-control-of-dyslipidemia-in-rural-south-africa-the-haalsi-health-and-aging-in-africa-a-longitudinal-study-of-an-indepth-community-in-south-africa-study
#14
Sheridan Reiger, Thiago Veiga Jardim, Shafika Abrahams-Gessel, Nigel J Crowther, Alisha Wade, F Xavier Gomez-Olive, Joshua Salomon, Stephen Tollman, Thomas A Gaziano
Dyslipidemia is a primary driver for chronic cardiovascular conditions and there is no comprehensive literature about its management in South Africa. The objective of this study was to assess the prevalence, awareness, treatment, and control of dyslipidemia in rural South Africa and how they are impacted by different behaviors and non-modifiable factors. To fulfill this objective we recruited for this cohort study adults aged ≥40 years residing in the Agincourt sub-district of Mpumalanga Province. Data collection included socioeconomic and clinical data, anthropometric measures, blood pressure (BP), HIV-status, point-of-care glucose and lipid levels...
2017: PloS One
https://www.readbyqxmd.com/read/29074587/relationship-between-total-serum-bilirubin-levels-and-carotid-and-femoral-atherosclerosis-in-familial-dyslipidemia
#15
Antonio J Amor, Emilio Ortega, Verónica Perea, Montserrat Cofán, Aleix Sala-Vila, Isabel Nuñez, Rosa Gilabert, Emilio Ros
OBJECTIVE: Bilirubin is a potent antioxidant that has been inversely related to cardiovascular disease. There is little information on serum total bilirubin (TB) in relation to atherosclerosis in familial dyslipidemia. We assessed the association between TB and carotid and femoral atherosclerosis in this high-risk group. APPROACH AND RESULTS: We evaluated 464 individuals with familial dyslipidemia (56% men; median age, 48 years), 322 with familial hypercholesterolemia, and 142 with familial combined hyperlipidemia...
December 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29064399/pharmabiotics-as-an-emerging-medication-for-metabolic-syndrome-and-its-related-diseases
#16
REVIEW
Thi Thanh Binh Nguyen, Yan Yan Jin, Hea-Jong Chung, Seong-Tschool Hong
Metabolic syndrome (MetS) is a cluster of metabolic risk factors associated with central obesity, hyperglycemia, insulin resistance, dyslipidemia and high blood pressure. In recent decades, because of the remarkable increase in both prevalence and severity, MetS and its related diseases such as cardiovascular diseases (CVDs), obesity, hypertension and diabetes have become the main global burden and challenge in strategic management involving prevention and treatment. However, currently, the preventions and treatments based on pharmaceutical interventions do not provide a solution for MetS and its related diseases...
October 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29026833/primary-prevention-of-cardiovascular-disease-in-older-adults-in-china
#17
REVIEW
Jian Yong, Dong Lin, Xue-Rui Tan
Over the past two decades, the percentage of Chinese who is 60 years or older has increased from 5.2% in 1995 to 10.5% in 2015. Approximately 16% of the population in China was 60 years old and above in 2015. Since 1990, cardiovascular disease (CVD) has been the leading cause of death in China. Cardiovascular medications of older adults are usually more complicated than younger age groups due to polypharmacy, the presence of comorbidities and more susceptible to treatment-related adverse outcomes. Therefore, effective primary prevention of CVD for older adults is important in sustaining the health of older adults and reducing the burden of the healthcare system...
September 16, 2017: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/29019423/national-hyperlipidemia-management-policies-improve-lipid-target-attainment-in-clinical-practice
#18
Fotios Barkas, Moses Elisaf
No abstract text is available yet for this article.
November 8, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28983166/cardiovascular-risk-factors-burden-in-saudi-arabia-the-africa-middle-east-cardiovascular-epidemiological-ace-study
#19
Amjad M Ahmed, Ahmad Hersi, Walid Mashhoud, Mohammed R Arafah, Paula C Abreu, Mohammed Abdullah Al Rowaily, Mouaz H Al-Mallah
BACKGROUND: Limited data exist on the epidemiology of cardiovascular risk factors in Saudi Arabia, particularly in relation to the differences between Saudi nationals and expatriates in Saudi Arabia. The aim of this analysis was to describe the current prevalence of cardiovascular risk factors among patients attending general practice clinics across Saudi Arabia. METHODS: In this cross-sectional epidemiological analysis of the Africa Middle East Cardiovascular Epidemiological (ACE) study, the prevalence of cardiovascular risk factors (hypertension, diabetes, dyslipidemia, obesity, smoking, abdominal obesity) was evaluated in adults attending primary care clinics in Saudi Arabia...
October 2017: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/28978986/the-relationship-between-obesity-and-hypertension-an-updated-comprehensive-overview-on-vicious-twins
#20
REVIEW
Massimo Leggio, Mario Lombardi, Elisa Caldarone, Paolo Severi, Stefania D'Emidio, Massimo Armeni, Veronica Bravi, Maria Grazia Bendini, Andrea Mazza
Obesity is a growing global health concern, with a rapid increase being observed in morbid obesity. Obesity is associated with an increased cardiovascular risk and earlier onset of cardiovascular morbidity. The growing obesity epidemic is a major source of unsustainable health costs and morbidity and mortality because of hypertension, type 2 diabetes mellitus, dyslipidemia, certain cancers and major cardiovascular diseases. Similar to obesity, hypertension is a key unfavorable health metric that has disastrous health implications: currently, hypertension is the leading contributor to global disease burden, and the direct and indirect costs of treating hypertension are exponentially higher...
October 5, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
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