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Dyslipidemia burden

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https://www.readbyqxmd.com/read/29783224/influence-of-risk-factors-on-insulin-resistance-in-patients-with-overweight-and-obesity
#1
Tetiana Maksymets, Natalia Karpyshyn, Taras Gutor, Helen Sklyarova, Eugen Sklyarov
OBJECTIVE: Introduction: Obesity is a multifactorial, heterogenic disease, associated with an increased risk of morbidity and mortality due to cardiovascular diseases, diabetes, cancer, chronic liver and kidney diseases. Excessive body weight and obesity are serious medical and social problems, since their incidence is constantly increasing and has reached global epidemic proportions. The aim: Determining the influence of risk factors on insulin resistance level in patients with overweight and obesity...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29782548/dyslipidemia-among-rural-and-urban-hiv-patients-in-south-east-malawi
#2
Alemayehu Amberbir, Victor Singano, Alfred Matengeni, Zahra Ismail, Gift Kawalazira, Adrienne K Chan, Sumeet D Sodhi, Joep J van Oosterhout
BACKGROUND: While dyslipidemia importantly contributes to increased cardiovascular disease risk among patients on antiretroviral therapy (ART), data on lipid patterns among African adults on ART are limited. We describe the prevalence of lipid abnormalities and associated factors in two HIV clinics in Malawi. METHODS: We conducted a cross-sectional study in 2014 and enrolled adult patients at a rural and an urban HIV clinic in Zomba district, Malawi. We recorded patient characteristics, CVD risk factors and anthropometric measurements, using the WHO STEPS validated instrument...
2018: PloS One
https://www.readbyqxmd.com/read/29780228/risk-factors-of-acute-ischemic-stroke-in-patients-presented-to-beni-suef-university-hospital-prevalence-and-relation-to-stroke-severity-at-presentation
#3
Rasha H Soliman, Mohammed I Oraby, Mohammed Fathy, Alaa M Essam
Background: Acute ischemic stroke is one of the major causes of disability and death worldwide. Effective prevention remains the best approach for reducing the burden of stroke. The aim of this work was to study the prevalence of stroke risk factors and the possible relation between such risk factors and the disease severity at presentation in a sample of stroke patients presented to Beni-Suef University Hospital, north Upper Egypt. Methods: A sample of 167 patients of acute ischemic stroke recruited from Beni-Suef University Hospital was included in this cross-sectional descriptive study...
2018: The Egyptian journal of neurology, psychiatry and neurosurgery
https://www.readbyqxmd.com/read/29753643/evaluation-of-community-pharmacists-preparedness-for-the-provision-of-cardiovascular-disease-risk-assessment-and-management-services-a-study-with-simulated-patients-in-qatar
#4
Monica Zolezzi, Oraib Abdallah, Nadir Kheir, Abdelsalam Gomaa Abdelsalam
BACKGROUND: Individuals who suffer from major cardiovascular events every year have one or more risk factors. Cardiovascular disease (CVD) risk assessment is an important strategy for the early identification of modifiable risk factors and their management. There is substantial evidence that shifting the focus from treatment to primary prevention reduces the burden of CVD. OBJECTIVES: To evaluate the preparedness of community pharmacists in Qatar for the provision of CVD risk assessment and management services; and to explore the pharmacists' views on the provision of these services...
April 28, 2018: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29753405/cardiovascular-disease-risk-in-children-with-kidney-disease
#5
REVIEW
Christine B Sethna, Kumail Merchant, Abigail Reyes
Cardiovascular disease is a major cause of death in individuals diagnosed with kidney disease during childhood. Children with kidney disease often incur a significant cardiovascular burden that leads to increased risk for cardiovascular disease. Evidence has shown that children with kidney disease, including chronic kidney disease, dialysis, kidney transplantation, and nephrotic syndrome, develop abnormalities in cardiovascular markers such as hypertension, dyslipidemia, left ventricular hypertrophy, left ventricular dysfunction, atherosclerosis, and aortic stiffness...
May 2018: Seminars in Nephrology
https://www.readbyqxmd.com/read/29749982/prevalence-of-multiple-coronary-artery-disease-risk-factors-in-kerman-a-population-based-study-in-southeast-iran
#6
Hamid Najafipour, Mahdi Afshari, Farzaneh Rostamzadeh
Background: The risk of disease with 1 risk factor is increased by the presence of additional risk factors. The goal of this study was to assess the prevalence of multiple coronary artery disease (CAD) risk factors among adults in Kerman, Iran, to identify the population groups most at risk. Methods: The present study included 5900 adults aged between 15 and 75 years in 2011 in Kerman, Iran. They were selected by 1-stage cluster sampling. Blood pressure, fasting blood glucose, lipids, and 6 CAD risk factors were assessed in the study population...
March 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29716848/worsening-of-the-cardiovascular-profile-in-a-developing-country-the-greater-beirut-area-cardiovascular-cohort
#7
Hussain A Isma'eel, Mohamad M Almedawar, Juliana Breidy, Mona Nasrallah, Nancy Nakhoul, Youssef Mouneimne, Lara Nasreddine, Nathalie Khoueiry-Zgheib, Mohamad Abiad, Hani Tamim
BACKGROUND: Lebanon has no established governmental noncommunicable diseases surveillance and monitoring system to permit reporting on noncommunicable diseases rates. The last World Health Organization-supported surveillance report showed worrying trends in cardiovascular disease (CVD) risk factors. OBJECTIVES: A cardiovascular cohort was established to permit CVD outcomes studies in an urban sample in the Lebanese capital and the study in hand presents the baseline CVD risk factors of this cohort...
April 28, 2018: Global Heart
https://www.readbyqxmd.com/read/29694507/protective-effect-of-yerba-mate-intake-on-the-cardiovascular-system-a-post-hoc-analysis-study-in-postmenopausal-women
#8
D T A da Veiga, R Bringhenti, R Copes, E Tatsch, R N Moresco, F V Comim, M O Premaor
The prevalence of cardiovascular and metabolic diseases is increased in postmenopausal women, which contributes to the burden of illnesses in this period of life. Yerba mate (Ilex paraguariensis) is a native bush from Southern South America. Its leaves are rich in phenolic components, which may have antioxidant, vasodilating, hypocholesterolemic, and hypoglycemic proprieties. This post hoc analysis of the case-control study nested in the Obesity and Bone Fracture Cohort evaluated the consumption of yerba mate and the prevalence of hypertension, dyslipidemia, and coronary diseases in postmenopausal women...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29666424/cardiovascular-markers-of-inflammation-and-serum-lipid-levels-in-hiv-infected-patients-with-undetectable-viremia
#9
Klaudija Višković, Snježana Židovec Lepej, Ana Gorenec, Ivana Grgić, Davorka Lukas, Šime Zekan, Anja Dragobratović, Maja Trupković, Josip Begovac
Patients successfully treated for HIV infection still have an increased risk for cardiovascular morbidity and mortality, which might be related not only to traditional risks, but also to inflammation and dyslipidemia. We examined the relationship of serum lipid levels with plasma biomarkers of inflammation using a composite inflammatory burden score (IBS) based on individual (>75th percentile) measurements from the following seven markers: CD40L, tPA, MCP-1, IL-8, IL-6, hCRP and P-selectin. IBS was categorized as 0 (none of the biomarkers >75th percentile), 1, 2 and 3 or more scores...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29663894/coenzyme-q10-in-cardiovascular-and-metabolic-diseases-current-state-of-the-problem
#10
Vladlena I Zozina, Serghei Covantev, Olga A Goroshko, Liudmila M Krasnykh, Vladimir G Kukes
The burden of cardiovascular and metabolic diseases is increasing with every year. Although the management of these conditions has improved greatly over the years it is still far from perfect. With all of this in mind, there is a need for new methods of prophylaxis and treatment. Coenzyme Q10 (CoQ10) is an essential compound of the human body. There is growing evidence that CoQ10 is tightly linked to cardiometabolic disorders. Its supplementation can be useful in a variety of chronic and acute disorders. This review analyses the role of CoQ10 in hypertension, ischemic heart disease, myocardial infarction, heart failure, viral myocarditis, cardiomyopathies, cardiac toxicity, dyslipidemia, obesity, type 2 diabetes mellitus, metabolic syndrome, cardiac procedures and resuscitation...
April 15, 2018: Current Cardiology Reviews
https://www.readbyqxmd.com/read/29662724/frequency-and-determinants-of-inappropriate-use-of-treadmill-stress-test-for-coronary-artery-disease
#11
Muhammad Bilal, Abdul Haseeb, Mohammad H Arshad, Altamash A Jaliawala, Iman Farooqui, Amna Minhas, Ahmedullah Hussaini, Arsalan A Khan, Sharjeel Ahmad, Zainab Saleem, Ozair Awan, Noor Us Sabahat, Araib Ayaz, Haania Rizwan
Background In developing countries like Pakistan, treatment is mediated by private and public healthcare setups with a limited budget for health facilities. Moreover, the inappropriate use of treadmill tests imposes a burden on healthcare resources and leads to unwarranted interventions. Our aim is to assess the prevalence and predictors of inappropriate referrals for the exercise tolerance test (ETT) to diagnose coronary artery disease (CAD) while taking public and private healthcare settings into consideration...
January 23, 2018: Curēus
https://www.readbyqxmd.com/read/29661561/clinically-actionable-hypercholesterolemia-and-hypertriglyceridemia-in-children-with-nonalcoholic-fatty-liver-disease
#12
Kathryn E Harlow, Jonathan A Africa, Alan Wells, Patricia H Belt, Cynthia A Behling, Ajay K Jain, Jean P Molleston, Kimberly P Newton, Philip Rosenthal, Miriam B Vos, Stavra A Xanthakos, Joel E Lavine, Jeffrey B Schwimmer
OBJECTIVE: To determine the percentage of children with nonalcoholic fatty liver disease (NAFLD) in whom intervention for low-density lipoprotein cholesterol or triglycerides was indicated based on National Heart, Lung, and Blood Institute guidelines. STUDY DESIGN: This multicenter, longitudinal cohort study included children with NAFLD enrolled in the National Institute of Diabetes and Digestive and Kidney Diseases Nonalcoholic Steatohepatitis Clinical Research Network...
April 13, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29618553/stroke-among-young-west-africans-evidence-from-the-siren-stroke-investigative-research-and-educational-network-large-multisite-case-control-study
#13
Fred Stephen Sarfo, Bruce Ovbiagele, Mulugeta Gebregziabher, Kolawole Wahab, Rufus Akinyemi, Albert Akpalu, Onoja Akpa, Reginald Obiako, Lukman Owolabi, Carolyn Jenkins, Mayowa Owolabi
BACKGROUND AND PURPOSE: Stroke in lower and middle-income countries affects a young and productive age group. Data on factors associated with stroke in the young are sorely lacking from lower and middle-income countries. Our objective is to characterize the nature of stroke and its risk factors among young West Africans aged <50 years old. METHODS: The SIREN (Stroke Investigative Research and Educational Network) is a multicenter, case-control study involving 15 sites in Nigeria and Ghana...
April 4, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29593789/drugs-involved-in-dyslipidemia-and-obesity-treatment-focus-on-adipose-tissue
#14
REVIEW
Sofia Dias, Sílvia Paredes, Laura Ribeiro
Metabolic syndrome can be defined as a state of disturbed metabolic homeostasis characterized by visceral obesity, atherogenic dyslipidemia, arterial hypertension, and insulin resistance. The growing prevalence of metabolic syndrome will certainly contribute to the burden of cardiovascular disease. Obesity and dyslipidemia are main features of metabolic syndrome, and both can present with adipose tissue dysfunction, involved in the pathogenic mechanisms underlying this syndrome. We revised the effects, and underlying mechanisms, of the current approved drugs for dyslipidemia and obesity (fibrates, statins, niacin, resins, ezetimibe, and orlistat; sibutramine; and diethylpropion, phentermine/topiramate, bupropion and naltrexone, and liraglutide) on adipose tissue...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29569857/hdl-associated-paraoxonase-1-activity-correlates-with-systemic-inflammation-disease-activity-and-cardiovascular-risk-factors-in-psoriatic-disease
#15
M Elaine Husni, W H Wilson Tang, Michael Lucke, U M Chandrasekharan, Danielle M Brennan, Stanley L Hazen
OBJECTIVE: To compare the activity of the HDL associated paraoxonase-1 (PON1) in psoriasis (PsO) and psoriatic arthritis (PsA) populations and its association with disease activity and cardiovascular disease (CVD) burden. METHODS: Serum paraoxonase and arylesterase activities (measures of PON1 function in humans) were measured in psoriatic arthritis (n=198, 51.0% male) and psoriasis (n=145, 50.3% male) patients enrolled in a longitudinal psoriatic disease biorepository...
March 23, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29519347/10-year-resource-utilization-and-costs-for-cardiovascular-care
#16
Leslee J Shaw, Abhinav Goyal, Christina Mehta, Joe Xie, Lawrence Phillips, Anita Kelkar, Joseph Knapper, Daniel S Berman, Khurram Nasir, Emir Veledar, Michael J Blaha, Roger Blumenthal, James K Min, Reza Fazel, Peter W F Wilson, Matthew J Budoff
BACKGROUND: Cardiovascular disease (CVD) imparts a heavy economic burden on the U.S. health care system. Evidence regarding the long-term costs after comprehensive CVD screening is limited. OBJECTIVES: This study calculated 10-year health care costs for 6,814 asymptomatic participants enrolled in MESA (Multi-Ethnic Study of Atherosclerosis), a registry sponsored by the National Heart, Lung, and Blood Institute, National Institutes of Health. METHODS: Cumulative 10-year costs for CVD medications, office visits, diagnostic procedures, coronary revascularization, and hospitalizations were calculated from detailed follow-up data...
March 13, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29473517/the-prevalence-of-dyslipidemia-and-other-cardiovascular-risk-factors-in-youth-with-diabetes
#17
Luke Hamilton, Don P Wilson, Crystal M O'Reilly, Jose Gonzalez, Alejandro de la Torre
BACKGROUND: Individuals diagnosed with diabetes mellitus have an increased risk of cardiovascular disease, often leading to premature morbidity and mortality. As the number of youth developing T1D and T2D continues to grow, early onset predisposes patients to a longer burden of disease and earlier onset of cardiovascular complications. Early identification and effective management and treatment of risk factors can lead to decreased cardiovascular events and improved quality of life. OBJECTIVE: In this study, we describe the prevalence of CVD risk factors in children with diabetes...
2017: Current Pediatric Reviews
https://www.readbyqxmd.com/read/29459263/hyperlipidemia-induces-typical-atherosclerosis-development-in-ldlr-and-apoe-deficient-rats
#18
Yongliang Zhao, Yiqing Yang, Roumei Xing, Xueqin Cui, Yufang Xiao, Ling Xie, Panpan You, Tongtong Wang, Li Zeng, Wenhui Peng, Dali Li, Huaqing Chen, Mingyao Liu
BACKGROUND AND AIMS: Low-density lipoprotein receptor (Ldlr) and apolipoprotein E (Apoe) knockout (KO) mice have been widely used as animal models of atherosclerosis. However, data suggested that it is difficult to develop typical atherosclerosis in rats. To this end, Ldlr and Apoe KO rats were generated and the potential to develop novel atherosclerosis models was evaluated. METHODS: We established Apoe/Ldlr single and double KO (DKO) rats via the CRISPR/Cas9 system in the same background...
April 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29455255/fasting-or-non-fasting-lipids-for-atherosclerotic-cardiovascular-disease-risk-assessment-and-treatment
#19
REVIEW
Faisal Rahman, Roger S Blumenthal, Steven R Jones, Seth S Martin, Tyler J Gluckman, Seamus P Whelton
PURPOSE OF REVIEW: Dyslipidemia is a major modifiable risk factor for atherosclerotic cardiovascular disease (ASCVD); however, lipid testing for risk assessment and treatment surveillance has been underutilized. Several factors likely account for this, including the common practice of measuring lipid levels in the fasting state, which often necessitates that patients return for an additional visit. In this review, we evaluate potential advantages and cautions associated with measuring lipids in the non-fasting state...
February 17, 2018: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29454222/obesity-dyslipidemia-and-brain-age-in-first-episode-psychosis
#20
Marian Kolenic, Katja Franke, Jaroslav Hlinka, Martin Matejka, Jana Capkova, Zdenka Pausova, Rudolf Uher, Martin Alda, Filip Spaniel, Tomas Hajek
INTRODUCTION: Obesity and dyslipidemia may negatively affect brain health and are frequent medical comorbidities of schizophrenia and related disorders. Despite the high burden of metabolic disorders, little is known about their effects on brain structure in psychosis. We investigated, whether obesity or dyslipidemia contributed to brain alterations in first-episode psychosis (FEP). METHODS: 120 participants with FEP, who were undergoing their first psychiatric hospitalization, had <24 months of untreated psychosis and were 18-35 years old and 114 controls within the same age range participated in the study...
April 2018: Journal of Psychiatric Research
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