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https://www.readbyqxmd.com/read/28290171/effects-of-surgical-techniques-on-long-term-results-in-patients-with-degenerative-mitral-valve-bileaflet-prolapse
#1
Giuseppe Petrone, Renato Bellitti, Clemente Pascarella, Gianantonio Nappi, Giuseppe Signoriello, Pasquale Santé
BACKGROUND: The study aim was to evaluate the long-term results in patients with degenerative mitral valve bileaflet prolapse (DMVBLP) undergoing mitral valve repair (MVr) or mitral valve replacement (MVR), and to compare the consequences of survival related to each technique. METHODS: Between 2001 and 2012, a total of 421 patients underwent isolated primary surgery for DMVBLP. MVr was performed in 146 patients (34.7%), and MVR in 275 (65.3%). MVR patients were allocated to two subgroups...
November 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28238235/prevalence-and-impact-of-prosthesis-patient-mismatch-following-surgical-aortic-valve-replacement-for-pure-aortic-regurgitation
#2
Vincent Auffret, Pierre Voisine, Alexandre Cinq-Mars, Éric Charbonneau, Florent Le Ven, Sacha-Michelle Dubois-Sénéchal, Eduardo Brenna, François Dagenais, Michelle Dubois, Carine Ridard, Mario Sénéchal
BACKGROUND: Prosthesis-patient mismatch (PPM) is highly prevalent among patients undergoing aortic valve replacement (AVR) to treat aortic stenosis. Data regarding the prevalence and impact of PPM on left ventricular remodeling and outcomes in patients who have undergone surgical AVR to treat pure severe aortic regurgitation (AR) are, however, scarce. METHODS: A retrospective analysis was conducted of clinical and echocardiographic data acquired from 50 consecutive patients with pure severe AR, without evidence of significant coronary artery disease, who underwent AVR between 2004 and 2010 at the authors' institution...
September 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28212603/effects-of-renal-denervation-on-cardiac-oxidative-stress-and-local-activity-of-the-sympathetic-nervous-system-and-renin-angiotensin-system-in-acute-myocardial-infracted-dogs
#3
Qiaoli Feng, Chengzhi Lu, Li Wang, Lijun Song, Chao Li, Ravi Chandra Uppada
BACKGROUND: This study sought to evaluate the therapeutic effects of renal denervation (RDN) on acute myocardial infarction (MI) in canines and explore its possible mechanisms of action. METHODS: Eighteen healthy mongrel dogs were randomly assigned to either the control group, the MI group or the MI + RDN group. To assess cardiac function, left ventricular ejection fraction (LVEF), left ventricular end-diastolic dimension (LVEDD), left ventricular end-systolic dimension (LVESD) and fraction shortening (FS) were recorded...
February 17, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28073832/reperfusion-therapy-with-recombinant-human-relaxin-2-serelaxin-attenuates-myocardial-infarct-size-and-nlrp3-inflammasome-following-ischemia-reperfusion-injury-via-enos-dependent-mechanism
#4
Juan Valle Raleigh, Adolfo G Mauro, Teja Devarakonda, Carlo Marchetti, Jun He, Erica Kim, Scott Filippone, Anindita Das, Stefano Toldo, Antonio Abbate, Fadi N Salloum
AIMS: The preconditioning-like infarct-sparing and anti-inflammatory effects of the peptide hormone relaxin following ischemic injury have been studied in the heart. Whether reperfusion therapy with recombinant human relaxin-2, serelaxin, reduces myocardial infarct size and attenuates the subsequent NLRP3 inflammasome activation leading to further loss of functional myocardium following ischemia/reperfusion (I/R) injury is unknown. METHODS AND RESULTS: After baseline echocardiography, adult male wild-type C57BL or eNOS knockout mice underwent myocardial infarction (MI) by coronary artery ligation for 30 min followed by 24 h reperfusion...
January 10, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28040769/evidence-of-subannular-and-left-ventricular-morphological-differences-in-patients-with-bicuspid-versus-tricuspid-aortic-valve-stenosis-magnetic-resonance-imaging-based-analysis
#5
Kushtrim Disha, Georg Dubslaff, Mina Rouman, Beatrix Fey, Michael A Borger, Alex J Barker, Thomas Kuntze, Evaldas Girdauskas
OBJECTIVES: Prospective analysis of left ventricular (LV) morphological/functional parameters in patients with bicuspid versus tricuspid aortic valve (TAV) stenosis undergoing aortic valve replacement (AVR) surgery. METHODS: A total of 190 consecutive patients with BAV (n = 154) and TAV stenosis (n = 36) (mean age 61 ± 8 years, 65% male) underwent AVR ± concomitant aortic surgery from January 2012 through May 2015. All patients underwent preoperative cardiac magnetic resonance imaging in order to evaluate: (i) left ventricular outflow tract (LVOT) dimensions, (ii) length of anterior mitral leaflet (AML), (iii) end-systolic and end-diastolic LV wall thickness, (iv) LV area, (v) LV end-systolic and end-diastolic diameters (LVESD, LVEDD), (vi) LV end-diastolic and end-systolic volumes (LVEDV, LVESV) and (vii) maximal diameter of aortic root...
December 31, 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/27882150/effect-of-stromal-cell-derived-factor-1-on-myocardial-apoptosis-and-cardiac-function-recovery-in-rats-with-acute-myocardial-infarction
#6
Yuanyuan Liu, Songtao Gao, Zheng Wang, Yan Yang, Hong Huo, Xuefeng Tian
The aim of the study was to investigate the effect of stromal cell-derived factor-1 (SDF-1) on myocardial apoptosis and cardiac function recovery in rats with acute myocardial infarction (AMI) and the mechanism of the Toll-like receptor (TLR)-4/nuclear factor-κB (NF-κB) signaling pathway. A total of 64 healthy male F344 rats were randomly divided into the sham operation, model, SDF-1 intervention and SDF-1 antibody groups, with 16 rats in each group. The method of Olivette was used to establish the AMI model by ligation of the left anterior descending artery...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27777294/impact-of-left-ventricular-to-mitral-valve-ring-mismatch-on-recurrent-ischemic-mitral-regurgitation-after-ring-annuloplasty
#7
Romain Capoulade, Xin Zeng, Jessica R Overbey, Gorav Ailawadi, John H Alexander, Deborah Ascheim, Michael Bowdish, Annetine C Gelijns, Paul Grayburn, Irving L Kron, Robert A Levine, Michael J Mack, Serguei Melnitchouk, Robert E Michler, John C Mullen, Patrick O'Gara, Michael K Parides, Peter Smith, Pierre Voisine, Judy Hung
BACKGROUND: In ischemic mitral regurgitation (IMR), ring annuloplasty is associated with a significant rate of recurrent MR. Ring size is based on intertrigonal distance without consideration of left ventricular (LV) size. However, LV size is an important determinant of mitral valve (MV) leaflet tethering before and after repair. We aimed to determine whether LV-MV ring mismatch (mismatch of LV size relative to ring size) is associated with recurrent MR in patients with IMR after restrictive ring annuloplasty...
October 25, 2016: Circulation
https://www.readbyqxmd.com/read/27764980/which-echocardiographic-parameter-is-a-better-marker-of-volume-status-in-hemodialysis-patients
#8
Tahereh Sabaghian, Bahareh Hajibaratali, Shiva Samavat
AIM: Bio-impedance analysis (BIA) is a preferred method for estimating the volume status. However, it cannot be utilized in daily practice. Since the assessment of the volume status is important and challenging for hemodialysis (HD) patients, the aim of study was to determine the volume status in chronic HD patients using echocardiographic parameters and assess its correlation with BIA. METHODS: In this cross-sectional analysis, echocardiography and BIA were performed on 30 chronic HD patients 30 min before and 30 min after dialysis...
November 2016: Renal Failure
https://www.readbyqxmd.com/read/27743853/comparison-of-various-strategies-for-the-prognosis-and-outcomes-of-ischaemic-dilated-cardiomyopathy-in-smokers-complete-revascularisation-and-smoking-cessation-produces-a-superior-outcome
#9
Jiahong Wang, Lan Zhao, Jiarui Wei, Shaoheng Zhang, Nannan Chen, Dongxing Ding, Qunlin Gong, Feng Su, Jian Yan, Pengxiang Zheng
BACKGROUND: Various therapies have been used to improve the symptoms and prognosis of patients with coronary artery disease. However, comparative studies showing more suitable choices for patients with ischaemic dilated cardiomyopathy (IDCM) and who smoke cigarettes are lacking. METHODS: A total of 338 patients were divided into four groups according to whether they received complete revascularisation (CR), and/or underwent smoking cessation (SC). They were followed prospectively for 12 months...
September 26, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27694999/the-impact-of-non-severe-burn-injury-on-cardiac-function-and-long-term-cardiovascular-pathology
#10
Emily O'Halloran, Amit Shah, Lawrence Dembo, Livia Hool, Helena Viola, Christine Grey, James Boyd, Tomas O'Neill, Fiona Wood, Janine Duke, Mark Fear
Severe burn injury significantly affects cardiovascular function for up to 3 years. However, whether this leads to long-term pathology is unknown. The impact of non-severe burn injury, which accounts for over 80% of admissions in developed countries, has not been investigated. Using a rodent model of non-severe burn injury with subsequent echocardiography we showed significantly increased left ventricular end systolic diameter (LVESD) and ventricular wall thickness at up to 3 months post-injury. Use of propranolol abrogated the changes in cardiac measures observed...
October 3, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27680576/changes-in-cardiac-function-and-structure-in-newly-diagnosed-graves-disease-a-conventional-and-2d-speckle-tracking-echocardiography-study
#11
K Aroditis, M Pikilidou, E Vourvouri, L Hadjistavri, P Zebekakis, J Yovos, G Efthimiadis, H Karvounis
Overproduction of thyroid hormones leads to structural as well as functional cardiac changes. Conventional echocardiography but also recently developed sophisticated two-dimensional echocardiography speckle (2D-STE) tracking allow elaborate evaluation of these changes. Our purpose was to investigate the effects of thyroid hormones overproduction on the heart in patients with Graves' disease and changes that occur after 6 months thyrostatic therapy. We conducted a prospective, case-control study of 6 months duration...
September 28, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27588093/magnetic-resonance-imaging-in-interventional-therapy-of-patients-with-acute-myocardial-infarction-prior-to-and-after-treatment
#12
Yuzhou Li, Chunrong Li, Hongrui Jin, Wenqi Huang
The aim of the study was to investigate the cardiac magnetic resonance (CMR) imaging in interventional therapy of patients with acute myocardial infarction prior to and after treatment. Fifty-six cases of AMI patients with elective treatment by percutaneous coronary intervention (PCI) were continuously selected. Patients with an incidence of 7-10 days were treated with CMR and echocardiography to evaluate the quality of myocardial infarction, visual score method (VSM), wall motion score abnormality, left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD) and left ventricular ejection fraction (LVEF)...
September 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27564775/thymopentin-improves-cardiac-function-in-older-patients-with-chronic-heart-failure
#13
Cao Xiaojing, Li Yanfang, Guo Yanqing, Cao Fangfang
OBJECTIVE: Recent studies have shown that activation of the immune system, inflammatory cell infiltration, and activation of inflammatory mediators play an important role in the development of heart failure. The purpose of this study was to investigate whether cardiac function can be improved by regulating the balance of lymphocyte subsets and cytokines. METHODS: Ninety-six patients with chronic heart failure (CHF) who were older than 60 years were randomly divided into two groups: CHF testing group (CHFT) received regular therapy and thymopentin (2 mg thymopentin per day, 15th as a course, three courses in total)...
August 23, 2016: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/27473036/nitrite-therapy-ameliorates-myocardial-dysfunction-via-h2s-and-nuclear-factor-erythroid-2-related-factor-2-nrf2-dependent-signaling-in-chronic-heart-failure
#14
Erminia Donnarumma, Shashi Bhushan, Jessica M Bradley, Hiroyuki Otsuka, Erinn L Donnelly, David J Lefer, Kazi N Islam
BACKGROUND: Bioavailability of nitric oxide (NO) and hydrogen sulfide (H2S) is reduced in heart failure (HF). Recent studies suggest cross-talk between NO and H2S signaling. We previously reported that sodium nitrite (NaNO2) ameliorates myocardial ischemia-reperfusion injury and HF. Nuclear factor-erythroid-2-related factor 2 (Nrf2) regulates the antioxidant proteins expression and is upregulated by H2S. We examined the NaNO2 effects on endogenous H2S bioavailability and Nrf2 activation in mice subjected to ischemia-induced chronic heart failure (CHF)...
2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27470569/fluvastatin-combined-with-benazepril-may-contribute-to-the-favorable-prognosis-of-patients-with-atrial-fibrillation
#15
RANDOMIZED CONTROLLED TRIAL
Hong Yao, Li Jiang, Xi Lin, Zhao-Guang Liang
The aim of this study was to observe the clinical efficacy of fluvastatin combined with benazepril in the treatment of patients with atrial fibrillation (AF). A total of 92 patients with AF were randomly assigned to the case group (n=46), in which the patients were treated with fluvastatin (80mg) plus benazepril (10mg), or to the control group (n=46), in which the patients were treated with fluvastatin (80mg). The conversion rate of sinus rhythm was higher in the case group than in the control group (P<0...
October 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27442881/toll-like-receptor-4-ablation-rescues-against-paraquat-triggered-myocardial-dysfunction-role-of-er-stress-and-apoptosis
#16
Yonghong Lei, Xue Li, Fang Yuan, Lu Liu, Juan Zhang, Yanping Yang, Jieqiong Zhao, Yan Han, Jun Ren, Xiaobing Fu
Paraquat is a nitrogen herbicide imposing severe organ toxicity in human leading to acute lung injury and heart failure. The present study was designed to examine the impact of ablation of the innate proinflammatory mediator toll-like receptor 4 (TLR4) in paraquat-induced cardiac contractile dysfunction and the underlying mechanisms involved with a focus on endoplasmic reticulum (ER) stress and apoptosis. Adult male wild-type (WT) and TLR4 knockout (TLR4(-/-) ) mice were challenged with paraquat (45 mg/kg, i...
February 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/27376817/echocardiographic-evaluation-of-cardiac-dyssynchrony-in-patients-with-congestive-heart-failure
#17
Chuan Qin, Li Zhang, Zi-Ming Zhang, Bin Wang, Zhou Ye, Yong Wang, Navin C Nanda, Ming-Xing Xie
The present study investigated the application of echocardiography to evaluation of cardiac dyssynchrony in patients with congestive heart failure (CHF). A total of 348 consecutive CHF patients who were admitted for cardiac resynchronization (CRT) and presented with low ejection fraction (EF) and wide QRS duration were enrolled in this study, along with 388 healthy individuals. Dyssynchrony was assessed based on filling time ratio (FT/RR), left ventricular pre-ejection delay (PED), interventricular mechanical delay (IVMD), longitudinal opposing wall delay (LOWD) and radial septal to posterior wall delay (RSPWD)...
June 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/27339493/effect-of-pulmonary-vascular-pressures-on%C3%A2-long-term-outcome-in-patients-with-primary-mitral-regurgitation
#18
Amgad Mentias, Krishna Patel, Harsh Patel, A Marc Gillinov, Joseph F Sabik, Tomislav Mihaljevic, Rakesh M Suri, L Leonardo Rodriguez, Lars G Svensson, Brian P Griffin, Milind Y Desai
BACKGROUND: Primary mitral regurgitation (MR) is a growing health problem due to the aging population. OBJECTIVES: The purpose of this study was to assess the impact of baseline pulmonary hypertension on long-term outcomes in patients with significant primary MR and preserved left ventricular ejection fraction (LVEF). METHODS: We studied 1,318 patients with ≥3+ primary MR and LVEF ≥60% using echocardiography at rest; they were evaluated at our center from 2005 to 2008...
June 28, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27323040/correlation-between-protein-4-1r-and-the-progression-of-heart-failure-in-vivo
#19
Z Wei, G Yang, R Xu, C Zhu, F He, Q Dou, J Tang
We aimed to assess the protein 4.1R (4.1R) expression of the membrane skeleton in cardiomyocytes and to determine the potential role of 4.1R in the pathogenesis of heart failure (HF). Forty-two male mice were randomly divided into two groups: an HF group (N = 22) and control group (N = 20). The HF model was established by abdominal subcutaneous injection of 5 mg⋅kg(-1)⋅day(-1) isopropyl adrenaline to the mice for 14 days. Electrocardiography was carried out and cardiac function was assessed by ultrasonic cardiogram...
May 13, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27220582/-relationship-between-myocardial-microrna-30a-expression-and-myocardial-fibrosis-in-rats-post-myocardial-infarction
#20
L W Chen, L L Zhu, Q Ji, H Zhu, Y Z Ren, Z G Fan, X B Li, X F Gao, Y J Zhang, N L Tian
OBJECTIVE: To explore the potential role and mechanism of microRNA(miR)-30a in myocardial fibrosis after myocardial infarction (MI). METHODS: Rats were randomly divided into 1 week MI group (n=11), 2 weeks MI group (n=13) and 4 weeks MI group (n=15) by applying random number table after left anterior descending coronary artery ligation. Rats in Sham group were examined at respective time points (n=16). Heart function was monitored by echocardiography. Myocardial collagen volume fraction (CVF) was determined on Masson stained sections...
May 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
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