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https://www.readbyqxmd.com/read/28734272/glycosylation-patterns-of-selected-proteins-in-individual-serum-and-cerebrospinal-fluid-samples
#1
Isabella Karlsson, Lorena Ndreu, Alessandro Quaranta, Gunnar Thorsén
A method we previously developed has been applied to the determination of the glycosylation pattern of specific proteins in biological samples. Six proteins (alpha-1-antitrypsin, transferrin, haptoglobin, C1 inhibitor, alpha-1 acid glycoprotein, and immunoglobulin G) were studied in serum samples from five individuals and cerebrospinal fluid (CSF) samples from three individuals, to investigate the expected normal distribution of glycosylation patterns and to assess whether this methodology can be used to discriminate between samples from different individuals...
April 25, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28734269/crime-scene-reconstruction-sex-prediction-from-blood-stained-foot-sole-impressions
#2
Nabanita Basu, Samir Kumar Bandyopadhyay
It is often difficult to predict the sex of an individual based on bloody incomplete footprints. However, such prints/impressions are particularly common in a crime scene. Again variability in the texture, color of the target surface has an impact on the bloodstained impression formed. The study of bare foot, footprint, footwear (i.e. shoe, canvas etc.) within the legal context is referred to as forensic podiatry. Based on the fact that it is possible to predict the sex of an individual from footprint impressions, an automated model has been proposed in this paper for analyzing the sex of an individual from his/her broken/incomplete footprint impressions based on morphological features alone...
June 26, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28734220/effect-analysis-of-quantum-chemical-descriptors-and-substituent-characteristics-on-henry-s-law-constants-of-polybrominated-diphenyl-ethers-at-different-temperatures
#3
Jiang Long, Qiu Youli, Li Yu
Twelve substituent descriptors, 17 quantum chemical descriptors and 1/T were selected to establish a quantitative structure-property relationship (QSPR) model of Henry's law constants for 7 polybrominated diphenyl ethers (PBDEs) at five different temperatures. Then, the lgH of 202 congeners at different temperatures were predicted. The variation rule and regulating mechanism of lgH was studied from the perspectives of both quantum chemical descriptors and substituent characteristics. The R(2) for modeling and testing sets of the final QSPR model are 0...
July 19, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28734192/trajectories-of-risk-behaviors-across-adolescence-and-young-adulthood-the-role-of-race-and-ethnicity
#4
Eunhee Park, Thomas P McCoy, Jennifer Toller Erausquin, Robin Bartlett
INTRODUCTION: Despite important advances of longitudinal research in substance use behaviors, most studies stratify analyses by gender or race, which limits the ability to directly compare the likelihood of a particular developmental pathway across demographic groups. Thus, there is critical need for well-designed research to examine the associations of race/ethnicity with developmental trajectories of substance use behaviors across adolescence through adulthood. METHODS: Using an accelerated longitudinal design, we examined behaviors across ages 12-31 from Waves I-IV of the National Longitudinal Study of Adolescent to Adult Health...
July 15, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28734177/manual-morphometry-of-hippocampus-and-amygdala-in-adults-with-attention-deficit-hyperactivity-disorder
#5
Kathrin Nickel, Ludger Tebartz van Elst, Evgeniy Perlov, Renate Jitten-Schachenmeier, Daniel Beier, Dominique Endres, Peter Goll, Alexandra Philipsen, Simon Maier
Previous studies have pointed to the involvement of limbic structures in the genesis of attention deficit hyperactivity disorder (ADHD). The present researchers manually segmented magnetic resonance images of 30 individuals with ADHD and 30 individually matched controls, focusing on amygdala and hippocampus volumes. Neither hippocampus nor amygdala volume differed significantly between individuals with and without ADHD. However, ADHD patients with higher hyperactivity scores had significantly smaller left amygdala volumes...
July 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28734175/cd8-t-cell-programming-by-cytomegalovirus-vectors-applications-in-prophylactic-and-therapeutic-vaccination
#6
REVIEW
Klaus Früh, Louis Picker
Vectors based on cytomegalovirus (CMV) represent a novel vaccine platform that maintains high frequencies of non-exhausted effector memory T cells in both CMV sero-positive and sero-negative individuals. In non-human primate models, CMV vectored vaccines provide unprecedented protection against simian immunodeficiency virus (SIV). Moreover, CMV vectors can be genetically altered to program highly diverse CD8+ T cell responses that differ in their epitope targeting including conventional, MHC-I restricted CD8+ T cells as well as unconventional CD8+ T cells restricted by MHC class II or non-polymorphic MHC-E...
July 19, 2017: Current Opinion in Immunology
https://www.readbyqxmd.com/read/28734148/apathy-in-early-and-late-life-depression
#7
Isis Groeneweg-Koolhoven, Merel Ploeg, Hannie C Comijs, Brenda Wjh Penninx, Roos C van der Mast, Robert A Schoevers, Didi Rhebergen, Eric van Exel
BACKGROUND: Late-life depression is thought to differ in clinical presentation from early-life depression. Particularly, late-life depression is considered to be more characterized by apathy than is early-life depression. Lacking convincing evidence, this study examines the presence and associated socio-demographic/clinical characteristics of apathy in older compared to younger depressed persons. METHODS: This cross-sectional study used data from two naturalistic cohort studies, i...
July 10, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28734138/ghrelin-plasma-concentration-does-not-covary-with-energy-demand-in-adult-laying-hens
#8
A Höhne, L Schrader, S Weigend, S Petow
The peptide hormone ghrelin is suggested to be involved in food intake regulation in young growing chicken. Whether ghrelin is involved in the regulation of energetic balance associated with laying performance in adult laying hens was studied by use of 4 chicken lines that differ in laying performance and phylogeny (4 lines; 16 hens per line). As housing conditions are also known to affect energy demand, half of the hens per line were housed in single cages and the other half of hens were maintained in a floor housing system...
June 29, 2017: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/28734131/changes-in-health-related-quality-of-life-in-older-candidates-waiting-for-kidney-transplantation
#9
Kjersti Lønning, Karsten Midtvedt, Tomm Bernklev, Cathrine Brunborg, Marit Helen Andersen, Nanna von der Lippe, Anna V Reisaeter, Pål-Dag Line, Anders Hartmann, Kristian Heldal
AIM: There is limited available knowledge regarding health-related quality of life (HRQoL) in older patients with chronic kidney disease. We aimed to describe HRQoL in renal transplant candidates 65 years or older at transplant acceptance, and during the first year on the waiting list.. METHODS: A nationwide prospective observational study in Norway was conducted. HRQoL was evaluated at baseline (wait listing) and after 6 and 12 months using the patient self-reported Kidney Disease and Quality of Life Short form version 1...
July 22, 2017: Nephrology
https://www.readbyqxmd.com/read/28732438/investigation-of-killer-immunoglobulin-like-receptor-kir-and-hla-genotypes-to-predict-the-occurrence-of-acute-allograft-rejection-after-kidney-transplantation
#10
Davood Jafari, Mohsen Nafar, Mir Saeed Yekaninejad, Razieh Abdolvahabi, Mahboob Lesan Pezeshki, Efat Razaghi, Ali Akbar Amirzargar
After kidney transplantation, natural killer (NK) cells play a pivotal role in triggering the immune response to the allogeneic grafts primarily by their killer-cell immunoglobulin-like receptors (KIR). This process may be one mechanism that contributes to graft rejection. In this study, we have evaluated whether acute rejection after kidney transplantation was associated with predicted NK cell alloreactivity based on KIR gene and ligand along with KIR/HLA compound genotype analysis. After kidney transplantation, natural killer (NK) cells play a pivotal role in triggering the immune response to the allogeneic grafts primarily by their killer-cell immunoglobulin-like receptors (KIR)...
June 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28732394/surface-charge-effects-on-the-electro-orientation-of-insulating-boron-nitride-nanotubes-in-aqueous-suspension
#11
Semih Cetindag, Bishnu Tiwari, Dongyan Zhang, Yoke Khin Yap, Sangil Kim, Jerry W Shan
The alignment of hexagonal boron-nitride nanotubes (BNNTs) in aqueous KCl solutions under spatially uniform electric fields was examined experimentally, using direct optical visualization to probe the orientation dynamics of individual BNNTs for different electric-field frequencies. Different from most previously studied nanowires and nanotubes, BNNTs are wide-bandgap materials which are essentially insulating at room temperature. We analyze the electro-orientation of BNNTs in the general context of polarizable cylindrical particles in liquid suspensions, whose behavior can fall into different regimes, including alignment due to Maxwell-Wagner induced dipoles at high frequencies, and alignment due to fluid motion of the electrical double layer around the particles at lower frequencies...
May 29, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28732372/combined-ki67-and-ercc1-for-prognosis-in-non-keratinizing-nasopharyngeal-carcinoma-underwent-chemoradiotherapy
#12
Ying Lu, Haixin Huang, Min Kang, Min Yi, Hui Yang, Sibei Wu, Rensheng Wang
This study aimed to assess the predictive value of combined Ki67 and ERCC1 in distant metastasis-free nasopharyngeal carcinoma. 334 such cases were retrospectively assessed. Immunohistochemistry was used to evaluate Ki67 and ERCC1 protein levels in tumor tissues. Associations of Ki67 and ERCC1 amounts with clinical characteristics and survival were analyzed. Medium follow-up was 48.7 months; overall survival (OS), disease-free survival (DFS), distant metastasis-free survival (DMFS), and local recurrence-free survival (LRFS) were 91...
July 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732323/evaluation-of-an-online-training-for-improving-self-reported-evidence-based-decision-making-skills-in-cancer-control-among-public-health-professionals
#13
A B Morshed, P Ballew, M B Elliott, D Haire-Joshu, M W Kreuter, R C Brownson
OBJECTIVES: The purpose of this evaluation was to assess the effect of the online evidence-based cancer control (EBCC) training on improving the self-reported evidence-based decision-making (EBDM) skills in cancer control among Nebraska public health professionals. STUDY DESIGN: Cross-sectional group comparison. METHODS: Previously developed EBDM measures were administered via online surveys to 201 public health professionals at baseline (comparison group) and 123 professionals who took part in the training...
July 18, 2017: Public Health
https://www.readbyqxmd.com/read/28732307/a-multisite-audit-to-assess-how-women-with-complex-social-factors-access-and-engage-with-maternity-services
#14
Hannah Rayment-Jones, Eleanor Butler, Chelsie Miller, Christine Nay, Jennifer O'Dowd
OBJECTIVE: to audit women with socially complex lives' documented access to and engagement with antenatal care provided by three inner city, UK maternity services in relation to birth and neonatal outcomes, and referral processes. BACKGROUND: women living socially complex lives, including young mothers, recently arrived immigrants, non-English speaking, and those experiencing domestic violence, poor mental health, drug and alcohol abuse, and poverty experience high rates of morbidity, mortality and poor birth outcomes...
June 27, 2017: Midwifery
https://www.readbyqxmd.com/read/28732295/determination-of-54-pesticides-in-waters-of-the-iberian-douro-river-estuary-and-risk-assessment-of-environmentally-relevant-mixtures-using-theoretical-approaches-and-artemia-salina-and-daphnia-magna-bioassays
#15
Catarina Cruzeiro, Sofia Amaral, Eduardo Rocha, Maria João Rocha
As a case study, the estuary of the international Douro River (Iberian Peninsula) was sampled over a year (2010) at six sampling sites to determine the presence of 56 pesticides of different categories (insecticides, herbicides, and fungicides). 96% of measured pesticides were detected in 79% of the quantified samples. Individual average pesticide concentrations ranged from 39 to 1 265ng/L, indicating a ubiquitous presence of the selected compounds; moreover, twelve pesticides were above the 2013/39/EU Directive limits...
July 18, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28732276/sampling-and-single-particle-analysis-for-the-chemical-characterisation-of-fine-atmospheric-particulates-a-review
#16
REVIEW
Michele Elmes, Massimo Gasparon
To better understand the potential environmental and human health impacts of fine airborne particulate matter (APM), detailed physical and chemical characterisation is required. The only means to accurately distinguish between the multiple compositions in APM is by single particle analysis. A variety of methods and instruments are available, which range from filter-based sample collection for off-line laboratory analysis to on-line instruments that detect the airborne particles and generate size distribution and chemical data in real time...
July 18, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28732268/validation-comparison-and-combination-of-algorithms-for-automatic-detection-of-pulmonary-nodules-in-computed-tomography-images-the-luna16-challenge
#17
Arnaud Arindra Adiyoso Setio, Alberto Traverso, Thomas de Bel, Moira S N Berens, Cas van den Bogaard, Piergiorgio Cerello, Hao Chen, Qi Dou, Maria Evelina Fantacci, Bram Geurts, Robbert van der Gugten, Pheng Ann Heng, Bart Jansen, Michael M J de Kaste, Valentin Kotov, Jack Yu-Hung Lin, Jeroen T M C Manders, Alexander Sóñora-Mengana, Juan Carlos García-Naranjo, Evgenia Papavasileiou, Mathias Prokop, Marco Saletta, Cornelia M Schaefer-Prokop, Ernst T Scholten, Luuk Scholten, Miranda M Snoeren, Ernesto Lopez Torres, Jef Vandemeulebroucke, Nicole Walasek, Guido C A Zuidhof, Bram van Ginneken, Colin Jacobs
Automatic detection of pulmonary nodules in thoracic computed tomography (CT) scans has been an active area of research for the last two decades. However, there have only been few studies that provide a comparative performance evaluation of different systems on a common database. We have therefore set up the LUNA16 challenge, an objective evaluation framework for automatic nodule detection algorithms using the largest publicly available reference database of chest CT scans, the LIDC-IDRI data set. In LUNA16, participants develop their algorithm and upload their predictions on 888 CT scans in one of the two tracks: 1) the complete nodule detection track where a complete CAD system should be developed, or 2) the false positive reduction track where a provided set of nodule candidates should be classified...
July 13, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28732256/using-the-theory-of-planned-behavior-incorporated-with-perceived-barriers-to-explore-sexual-counseling-services-delivered-by-healthcare-professionals-in-individuals-suffering-from-epilepsy
#18
Chung-Ying Lin, Xavier C C Fung, Mehdi Nikoobakht, Andrea Burri, Amir H Pakpour
People with epilepsy (PWE) are highly likely to suffer from sexual dysfunction, and dealing with this issue is a challenge for healthcare providers. Unfortunately, there is no theory-driven study that has investigated the counseling practice of healthcare providers for sexual problems in PWE. Therefore, we decided to apply the well-established Theory of Planned Behavior (TPB) to examine factors associated with healthcare providers' sexual counseling in PWE. Apart from TPB, perceived barriers toward providing counseling could be a possible factor that needs to be investigated as well...
July 18, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28732249/evaluating-alzheimer-s-disease-biomarkers-as-mediators-of-age-related-cognitive-decline
#19
Timothy J Hohman, Doug Tommet, Shawn Marks, Joey Contreras, Rich Jones, Dan Mungas
Age-related changes in cognition are partially mediated by the presence of neuropathology and neurodegeneration. This manuscript evaluates the degree to which biomarkers of Alzheimer's disease, (AD) neuropathology and longitudinal changes in brain structure, account for age-related differences in cognition. Data from the AD Neuroimaging Initiative (n = 1012) were analyzed, including individuals with normal cognition and mild cognitive impairment. Parallel process mixed effects regression models characterized longitudinal trajectories of cognitive variables and time-varying changes in brain volumes...
July 4, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28732176/a-comprehensive-craniofacial-study-of-22q11-2-deletion-syndrome
#20
A Lewyllie, J Roosenboom, K Indencleef, P Claes, A Swillen, K Devriendt, C Carels, M Cadenas De Llano-Pérula, G Willems, G Hens, A Verdonck
The 22q11.2 deletion syndrome (22q11.2DS) is one of the most frequent microdeletion syndromes and presents with a highly variable phenotype. In most affected individuals, specific but subtle facial features can be seen. In this observational study, we aim to investigate the craniofacial and dental features of 20 children with a confirmed diagnosis of 22q11.2DS by analyzing 3-dimensional (3D) facial surface scans, 2-dimensional (2D) clinical photographs, panoramic and cephalometric radiographs, and dental casts...
July 1, 2017: Journal of Dental Research
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