keyword
https://read.qxmd.com/read/38546583/lack-of-elevated-expression-of-tgf%C3%AE-3-contributes-to-the-delay-of-epithelial-wound-healing-in-diabetic-corneas
#1
JOURNAL ARTICLE
Nan Gao, Fu-Shin Yu
PURPOSE: To investigate the mechanisms underlying the differential roles of TGFβ1 and TGFβ3 in accelerating corneal epithelial wound healing (CEWH) in diabetic (DM) corneas, with normoglycemia (NL) corneas as the control. METHODS: Two types of diabetic mice, human corneal organ cultures, mouse corneal epithelial progenitor cell lines, and bone marrow-derived macrophages (BMDMs) were employed to assess the effects of TGFβ1 and TGFβ3 on CEWH, utilizing quantitative PCR, western blotting, ELISA, and whole-mount confocal microscopy...
March 5, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38546137/understanding-exososmes-part-3-therapeutic-diagnostic-potential-in-dentistry
#2
REVIEW
Richard J Miron, Nathan E Estrin, Anton Sculean, Yufeng Zhang
Exosomes are the smallest subset of extracellular signaling vesicles secreted by most cells with the ability to communicate with other tissues and cell types over long distances. Their use in regenerative medicine has gained tremendous momentum recently due to their ability to be utilized as therapeutic options for a wide array of various diseases. Over 5000 publications are currently being published on this topic yearly, many of which in the dental space. This extensive review article is the first scoping review aimed at summarizing all therapeutic uses of exosomes in regenerative dentistry...
March 28, 2024: Periodontology 2000
https://read.qxmd.com/read/38545108/the-role-of-foam-cells-in-spinal-cord-injury-challenges-and-opportunities-for-intervention
#3
REVIEW
Xiao-Xin Wang, Ze-Hui Li, Hua-Yong Du, Wu-Bo Liu, Chun-Jia Zhang, Xin Xu, Han Ke, Run Peng, De-Gang Yang, Jian-Jun Li, Feng Gao
Spinal cord injury (SCI) results in a large amount of tissue cell debris in the lesion site, which interacts with various cytokines, including inflammatory factors, and the intrinsic glial environment of the central nervous system (CNS) to form an inhibitory microenvironment that impedes nerve regeneration. The efficient clearance of tissue debris is crucial for the resolution of the inhibitory microenvironment after SCI. Macrophages are the main cells responsible for tissue debris removal after SCI. However, the high lipid content in tissue debris and the dysregulation of lipid metabolism within macrophages lead to their transformation into foamy macrophages during the phagocytic process...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38544794/fas-ligand-regulate-nerve-injury-and-repair-by-affecting-akt-%C3%AE-catenin-and-nf-%C3%AE%C2%BAb-pathways
#4
JOURNAL ARTICLE
Yiyue Zhou, Yi Yao, Yumei Feng, Zhiyuan Qiu, Shixian Luo, Xinyu Shi, Dandan Gu, Maorong Jiang, Min Cai, Dengbing Yao
OBJECTIVE: To investigate the regulatory effect of Fas-L on the repair and regeneration of peripheral extension injury in rats. METHODS: This study aimed to explore the effects of Fas-L on apoptosis and axonal regeneration of dorsal root ganglion (DRG) cells in rat peripheral nerve repair and regeneration by using several relevant experimental techniques from the injured nerve animal model, cell biology, and molecular biology. RESULTS: The expression level of Fas-L in DRG tissues was significantly down-regulated after sciatic nerve injury...
June 2024: IBRO neuroscience reports
https://read.qxmd.com/read/38542483/cell-heterogeneity-and-variability-in-peripheral-nerve-after-injury
#5
REVIEW
Zhixian Ren, Ya Tan, Lili Zhao
With the development of single-cell sequencing technology, the cellular composition of more and more tissues is being elucidated. As the whole nervous system has been extensively studied, the cellular composition of the peripheral nerve has gradually been revealed. By summarizing the current sequencing data, we compile the heterogeneities of cells that have been reported in the peripheral nerves, mainly the sciatic nerve. The cellular variability of Schwann cells, fibroblasts, immune cells, and endothelial cells during development and disease has been discussed in this review...
March 20, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542232/multilayer-electrospun-scaffolds-of-opposite-charged-chitosans
#6
JOURNAL ARTICLE
Cristian Balducci, Martina Roso, Annj Zamuner, Lucia Falcigno, Gabriella D'Auria, Paola Brun, Monica Dettin
Chitosan (CS) is a polysaccharide obtainable by the deacetylation of chitin, which is highly available in nature and is consequently low-cost. Chitosan is already used in the biomedical field (e.g., guides for nerve reconstruction) and has been proposed as a biomaterial for tissue regeneration in different body districts, including bone tissue. The interest in chitosan as a biomaterial stems from its ease of functionalization due to the presence of reactive groups, its antibacterial properties, its ease of processing to obtain porous matrices, and its inherent similarity to polysaccharides that constitute the human extracellular matrix, such as hyaluronic acid (HA)...
March 13, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38540168/corneal-sub-basal-nerve-plexus-regeneration-pattern-following-implantable-collamer-lens-implantation-for-myopia-a-prospective-longitudinal-in-vivo-confocal-microscopy-study
#7
JOURNAL ARTICLE
Qiaoling Wei, Xuan Ding, Weiteng Chang, Xianjin Zhou, Rui Jiang, Xingtao Zhou, Zhiqiang Yu
Implantable Collamer Lens (ICL) surgery has increasingly been adopted for myopia correction in recent decades. This study, employing in vivo confocal microscopy (IVCM), aimed to assess the impact of corneal incision during ICL surgery on the corneal sub-basal nerve plexus (SNP) and adjacent immune dendritiform cells (DCs). In this longitudinal study, eyes from 53 patients undergoing ICL surgery were assessed preoperatively and postoperatively over a twelve-month period. Quantification of seven SNP parameters was performed using ACCMetrics V...
March 1, 2024: Biomedicines
https://read.qxmd.com/read/38540102/effects-of-physical-cues-on-stem-cell-derived-extracellular-vesicles-toward-neuropathy-applications
#8
REVIEW
Danyale Berry, Justice Ene, Aakash Nathani, Mandip Singh, Yan Li, Changchun Zeng
The peripheral nervous system undergoes sufficient stress when affected by diabetic conditions, chemotherapeutic drugs, and personal injury. Consequently, peripheral neuropathy arises as the most common complication, leading to debilitating symptoms that significantly alter the quality and way of life. The resulting chronic pain requires a treatment approach that does not simply mask the accompanying symptoms but provides the necessary external environment and neurotrophic factors that will effectively facilitate nerve regeneration...
February 22, 2024: Biomedicines
https://read.qxmd.com/read/38539981/early-intensive-neurorehabilitation-in-traumatic-peripheral-nerve-injury-state-of-the-art
#9
REVIEW
Débora Gouveia, Ana Cardoso, Carla Carvalho, Ana Catarina Oliveira, António Almeida, Óscar Gamboa, Bruna Lopes, André Coelho, Rui Alvites, Artur Severo Varejão, Ana Colette Maurício, António Ferreira, Ângela Martins
Traumatic nerve injuries are common lesions that affect several hundred thousand humans, as well as dogs and cats. The assessment of nerve regeneration through animal models may provide information for translational research and future therapeutic options that can be applied mutually in veterinary and human medicine, from a One Health perspective. This review offers a hands-on vision of the non-invasive and conservative approaches to peripheral nerve injury, focusing on the role of neurorehabilitation in nerve repair and regeneration...
March 13, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38538214/fasting-a-potential-intervention-in-alzheimer-s-disease
#10
REVIEW
Zhengzhong Zeng, Hu Zhang, Xianping Wang, Jiawen Shen, Danyang Chen
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the onset of symptoms, typically occurring later in life, and significant deficits in cognitive functions including learning, memory, speech, and behavior. Ongoing research endeavors seek to explore methods for preventing and treating AD, as well as delving into the molecular mechanisms underlying existing and novel therapeutic approaches encompassing exercise, diet, and drug regimens for individuals with AD or those at risk of developing AD...
March 4, 2024: Journal of Integrative Neuroscience
https://read.qxmd.com/read/38535505/quantitative-proteomics-reveal-region-specific-alterations-in-neuroserpin-deficient-mouse-brain-and-retina-insights-into-serpini1-function
#11
JOURNAL ARTICLE
Shahab Mirshahvaladi, Nitin Chitranshi, Ardeshir Amirkhani, Rashi Rajput, Devaraj Basavarajappa, Roshana Vander Wall, Dana Pascovici, Angela Godinez, Giovanna Galliciotti, Joao A Paulo, Veer Gupta, Stuart L Graham, Vivek Gupta, Mehdi Mirzaei
Neural regeneration and neuroprotection represent strategies for future management of neurodegenerative disorders such as Alzheimer's disease (AD) or glaucoma. However, the complex molecular mechanisms that are involved in neuroprotection are not clearly understood. A promising candidate that maintains neuroprotective signaling networks is neuroserpin (Serpini1), a serine protease inhibitor expressed in neurons which selectively inhibits extracellular tissue-type plasminogen activator (tPA)/plasmin and plays a neuroprotective role during ischemic brain injury...
March 14, 2024: Proteomes
https://read.qxmd.com/read/38534854/review-of-spider-silk-applications-in-biomedical-and-tissue-engineering
#12
REVIEW
Marija Branković, Fatima Zivic, Nenad Grujovic, Ivan Stojadinovic, Strahinja Milenkovic, Nikola Kotorcevic
This review will present the latest research related to the production and application of spider silk and silk-based materials in reconstructive and regenerative medicine and tissue engineering, with a focus on musculoskeletal tissues, and including skin regeneration and tissue repair of bone and cartilage, ligaments, muscle tissue, peripheral nerves, and artificial blood vessels. Natural spider silk synthesis is reviewed, and the further recombinant production of spider silk proteins. Research insights into possible spider silk structures, like fibers (1D), coatings (2D), and 3D constructs, including porous structures, hydrogels, and organ-on-chip designs, have been reviewed considering a design of bioactive materials for smart medical implants and drug delivery systems...
March 11, 2024: Biomimetics
https://read.qxmd.com/read/38534336/progressive-irreversible-proprioceptive-piezo2-channelopathy-induced-lost-forced-peripheral-oscillatory-synchronization-to-the-hippocampal-oscillator-may-explain-the-onset-of-amyotrophic-lateral-sclerosis-pathomechanism
#13
JOURNAL ARTICLE
Balázs Sonkodi
Amyotrophic lateral sclerosis (ALS) is a mysterious lethal multisystem neurodegenerative disease that gradually leads to the progressive loss of motor neurons. A recent non-contact dying-back injury mechanism theory for ALS proposed that the primary damage is an acquired irreversible intrafusal proprioceptive terminal Piezo2 channelopathy with underlying genetic and environmental risk factors. Underpinning this is the theory that excessively prolonged proprioceptive mechanotransduction under allostasis may induce dysfunctionality in mitochondria, leading to Piezo2 channelopathy...
March 12, 2024: Cells
https://read.qxmd.com/read/38533079/-scutellaria-baicalensis-georgi-stems-and-leaves-flavonoids-promote-neuroregeneration-and-ameliorate-memory-loss-in-rats-through-camp-pka-creb-signaling-pathway-based-on-network-pharmacology-and-bioinformatics-analysis
#14
JOURNAL ARTICLE
Yinhui Yao, Qianqian Liu, Shengkai Ding, Yan Chen, Tangtang Song, Yazhen Shang
The aim of this study was to investigate the possible molecular mechanism of Scutellaria baicalensis Georgi stems and leaves flavonoids (SSF) in Alzheimer's disease (AD). The active ingredients of SSF and their targets were identified via network pharmacology and bioinformatics analysis. To test the successful establishment of a rat model of AD by Aβ25-35 combined with RHTGF- β 1 and AlCl3 , the Morris water maze test was used. To intervene, three different doses of SSF were administered. The model group and the control group were included among the parallel groups...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38531346/bioactive-nanofiber-hydrogel-composite-regulates-regenerative-microenvironment-for-skeletal-muscle-regeneration-after-volumetric-muscle-loss
#15
JOURNAL ARTICLE
Wei Yu, Xiangqi Zhang, Muge Gu, Jiayu Wang, Yihui Zhang, Wenkai Zhang, Wei-En Yuan
Volumetric muscle loss (VML) is a severe form of muscle trauma that exceeds the regenerative capacity of skeletal muscle tissue, leading to substantial functional impairment. The abnormal immune response and excessive reactive oxygen species (ROS) accumulation hinder muscle regeneration following VML. Here, we engineered an interfacial cross-linked hydrogel-poly(ε-caprolactone) nanofiber composite that incorporates both biophysical and biochemical cues to modulate the immune and ROS microenvironment for enhanced VML repair...
March 26, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38530974/conductive-and-enhanced-mechanical-strength-of-mo-2-ti-2-c-3-mxene-based-hydrogel-promotes-neurogenesis-and-bone-regeneration-in-bone-defect-repair
#16
JOURNAL ARTICLE
Hongyu Wang, Yu-Ching Hsu, Chune Wang, Xiao Xiao, Zhengbin Yuan, Yong Zhu, Dazhi Yang
Bone defects are common with increasing high-energy fractures, tumor bone invasion, and implantation revision surgery. Bone is an electroactive tissue that has electromechanical interaction with collogen, osteoblasts, and osteoclasts. Hydrogel provides morphological plasticity and extracellular matrix (ECM) 3D structures for cell survival, and is widely used as a bone engineering material. However, the hydrogels have poor mechanical intensity and lack of cell adhesion, slow gelation time, and limited conductivity...
March 26, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38530570/modulation-of-inflammatory-responses-to-enhance-nerve-recovery-after-spinal-cord-injury
#17
EDITORIAL
Young-Kwon Seo
Inflammation can occur at the wound site, and immune cells are necessary to trigger wound healing and tissue regeneration after injury. It is partly initiated by the rapid migration of immune cells such as neutrophils, inflammatory monocytes, and macrophages after spinal cord injury (SCI). Secondary inflammation can increase the wound area; thus, the function of tissues below the injury levels. Monocytes can differentiate into macrophages, and the macrophage phenotype can change from a pro-inflammatory phenotype to an anti-inflammatory phenotype...
March 26, 2024: Tissue Engineering and Regenerative Medicine
https://read.qxmd.com/read/38527183/topical-insulin-for-ocular-surface-disease
#18
JOURNAL ARTICLE
Pau Cid-Bertomeu, Magí Vilaltella, Mireia Martínez, Marta Mir, Valentín Huerva
Background: Insulin and insulin-like growth factor (IGF)-1 receptors are present in ocular tissues such as corneal epithelium, keratocytes, and conjunctival cells. Insulin plays a crucial role in the growth, differentiation, and proliferation of corneal epithelial cells, as well as in wound healing processes in various tissues. Purpose: This review explores the potential role of topical insulin in the treatment of ocular surface diseases. Specifically, it examines its impact on corneal nerve regeneration, sub-basal plexus corneal nerves, and its application in conditions like corneal epithelial defects, dry eye disease, and diabetic keratopathy...
March 22, 2024: Journal of Ocular Pharmacology and Therapeutics
https://read.qxmd.com/read/38526290/optimal-transcorneal-electrical-stimulation-parameters-for-preserving-photoreceptors-in-a-mouse-model-of-retinitis-pigmentosa
#19
JOURNAL ARTICLE
Sam Enayati, Karen Chang, Anton Lennikov, Menglu Yang, Cherin Lee, Ajay Ashok, Farris Elzaridi, Christina Yen, Kasim Gunes, Jia Xie, Kin-Sang Cho, Tor Paaske Utheim, Dong Feng Chen
JOURNAL/nrgr/04.03/01300535-202419110-00034/figure1/v/2024-03-08T184507Z/r/image-tiff Retinitis pigmentosa is a hereditary retinal disease that affects rod and cone photoreceptors, leading to progressive photoreceptor loss. Previous research supports the beneficial effect of electrical stimulation on photoreceptor survival. This study aims to identify the most effective electrical stimulation parameters and functional advantages of transcorneal electrical stimulation (tcES) in mice affected by inherited retinal degeneration...
November 1, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38526289/neuroprotective-effects-of-g9a-inhibition-through-modulation-of-peroxisome-proliferator-activator-receptor-gamma-dependent-pathways-by-mir-128
#20
JOURNAL ARTICLE
Aina Bellver-Sanchis, Pedro A Ávila-López, Iva Tic, David Valle-García, Marta Ribalta-Vilella, Luis Labrador, Deb Ranjan Banerjee, Ana Guerrero, Gemma Casadesus, Coralie Poulard, Mercè Pallàs, Christian Griñán-Ferré
JOURNAL/nrgr/04.03/01300535-202419110-00033/figure1/v/2024-03-08T184507Z/r/image-tiff Dysregulation of G9a, a histone-lysine N-methyltransferase, has been observed in Alzheimer's disease and has been correlated with increased levels of chronic inflammation and oxidative stress. Likewise, microRNAs are involved in many biological processes and diseases playing a key role in pathogenesis, especially in multifactorial diseases such as Alzheimer's disease. Therefore, our aim has been to provide partial insights into the interconnection between G9a, microRNAs, oxidative stress, and neuroinflammation...
November 1, 2024: Neural Regeneration Research
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