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Nerve Regeneration

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https://www.readbyqxmd.com/read/29775143/testing-the-effectiveness-and-the-contribution-of-experimental-supercharge-reversed-end-to-side-nerve-transfer
#1
Mustafa Nadi, Sudheesh Ramachandran, Abir Islam, Joanne Forden, Gui Fang Guo, Rajiv Midha
OBJECTIVE Supercharge end-to-side (SETS) transfer, also referred to as reverse end-to-side transfer, distal to severe nerve compression neuropathy or in-continuity nerve injury is gaining clinical popularity despite questions about its effectiveness. Here, the authors examined SETS distal to experimental neuroma in-continuity (NIC) injuries for efficacy in enhancing neuronal regeneration and functional outcome, and, for the first time, they definitively evaluated the degree of contribution of the native and donor motor neuron pools...
May 18, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29774231/semaphorin3a-signaling-is-dispensable-for-motor-axon-reinnervation-of-the-adult-neuromuscular-junction
#2
Jennifer L Shadrach, Brian A Pierchala
The neuromuscular junction (NMJ) is a specialized synapse that is formed by motor axon innervation of skeletal muscle fibers. The maintenance of motor-muscle connectivity is critical for the preservation of muscle tone and generation of movement. Injury can induce a robust regenerative response in motor axons, but severe trauma or chronic denervation resulting from neurodegenerative disease typically leads to inefficient repair and poor functional recovery. The axon guidance molecule Semaphorin3A (Sema3A) has been implicated as a negative regulator of motor innervation...
May 2018: ENeuro
https://www.readbyqxmd.com/read/29770392/promotion-of-neurite-outgrowth-by-rationally-designed-ngf-%C3%AE-binding-peptide-nanofibers
#3
Zeynep Okur, Oya I Senturk, Canelif Yilmaz, Gulcihan Gulseren, Busra Mammadov, Mustafa O Guler, Ayse B Tekinay
Promotion of neurite outgrowth is an important limiting step for regeneration in nerve injury and depends strongly on the local expression of nerve growth factor (NGF). The rational design of bioactive materials is a promising approach for the development of novel therapeutic methods for nerve regeneration, and biomaterials capable of presenting NGF to nerve cells are especially suitable for this purpose. In this study, we show bioactive peptide amphiphile (PA) nanofibers capable of promoting neurite outgrowth by displaying high density binding epitopes for NGF...
May 17, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29768956/-express-attenuation-of-trpv1-by-amg-517-after-nerve-injury-promotes-peripheral-axonal-regeneration-in-rats
#4
Juan Bai, F U Liu, Li-Fei Wu, Ya-Fang Wang, Xia-Qing Li
AIMS: The main objective was to investigate the effects of the transient receptor potential cation channel subfamily V member 1 (TRPV1) on nerve regeneration following sciatic transection injury by functional blockage of TRPV1 using AMG-517, a specific blocker of TRPV1. METHODS: AMG-517 was injected into the area surrounding ipsilateral lumbar dorsal root ganglia (DRGs) 30 min after unilateral sciatic nerve transection. The number of sciatic axons and the expression of growth associated protein-43 (GAP-43) and glial fibrillary acidic protein (GFAP) were examined using semi-thin sections, western blot, and immunofluorescence analyses...
January 1, 2018: Molecular Pain
https://www.readbyqxmd.com/read/29768445/nogo-receptor-1-is-expressed-by-nearly-all-retinal-ganglion-cells
#5
Alexander M Solomon, Teleza Westbrook, Greg D Field, Aaron W McGee
A variety of conditions ranging from glaucoma to blunt force trauma lead to optic nerve atrophy. Identifying signaling pathways for stimulating axon growth in the optic nerve may lead to treatments for these pathologies. Inhibiting signaling by the nogo-66 receptor 1 (NgR1) promotes the re-extension of axons following a crush injury to the optic nerve, and while NgR1 mRNA and protein expression are observed in the retinal ganglion cell (RGC) layer and inner nuclear layer, which retinal cell types express NgR1 remains unknown...
2018: PloS One
https://www.readbyqxmd.com/read/29768188/micropatterned-biodegradable-polyesters-clicked-with-cqaasikvav-promote-cell-alignment-directional-migration-and-neurite-outgrowth
#6
Deteng Zhang, Sai Wu, Jianyong Feng, Yiyuan Duan, Dongming Xing, Changyou Gao
The interplay of microstructures and biological cues is critical to regulate the behaviors of Schwann cells (SCs) in terms of cellular spatial arrangement and directional migration as well as neurite orientation for bridging the proximal and distal stumps of the injured peripheral nervous system. In this study, stripe micropatterns having ridges/grooves of width 20/20 and 20/40 μm were fabricated on the surface of maleimide-functionalized biodegradable poly(ester carbonate) (P(LLA-MTMC)) films by the polydimethylsiloxane mold-pressing method, respectively...
May 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29767652/peripheral-glial-cell-line-derived-neurotrophic-factor-facilitates-the-functional-recovery-of-mechanical-nociception-following-inferior-alveolar-nerve-transection-in-rats
#7
Masahiro Watanabe, Masamichi Shinoda, Dulguun Batbold, Naoyuki Sugano, Shuichi Sato, Koichi Iwata
AIMS: To identify endogenous sources of glial cell line-derived neurotrophic factor (GDNF) at the injury site following inferior alveolar nerve transection (IANX) and to determine whether GDNF signaling promotes the recovery of orofacial pain sensation. METHODS: Nociceptive mechanical sensitivity of the facial skin was assessed following IANX (n = 10) or sham operation (n = 7). GDNF-positive cells were identified and the amount of GDNF measured in the injured region of IANX rats (n = 10) and in sham rats (n = 10)...
May 15, 2018: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29766041/report-on-the-national-eye-institute-s-audacious-goals-initiative-creating-a-cellular-environment-for-neuroregeneration
#8
Marie E Burns, Beth Stevens
The cellular environment of the CNS is non-permissive for growth and regeneration. In the retina, transplantation of stem cells has been limited by inefficient survival and integration into existing circuits. In November 2016, as part of the National Eye Institute's Audacious Goals Initiative (AGI), a diverse collection of investigators gathered for a workshop devoted to articulating the gaps in knowledge, barriers to progress, and ideas for new approaches to understanding cellular environments within the retina and how these environments may be manipulated...
March 2018: ENeuro
https://www.readbyqxmd.com/read/29766020/amelioration-of-muscle-and-nerve-pathology-in-lama2-muscular-dystrophy-by-aav9-mini-agrin
#9
Chunping Qiao, Yi Dai, Viktoriya D Nikolova, Quan Jin, Jianbin Li, Bin Xiao, Juan Li, Sheryl S Moy, Xiao Xiao
LAMA2-related muscular dystrophy (LAMA2 MD) is the most common and fatal form of early-onset congenital muscular dystrophies. Due to the large size of the laminin α2 cDNA and heterotrimeric structure of the protein, it is challenging to develop a gene-replacement therapy. Our group has developed a novel adeno-associated viral (AAV) vector carrying the mini-agrin, which is a non-homologous functional substitute for the mutated laminin α2. A significant therapeutic effect in skeletal muscle was observed in our previous study using AAV serotype 1 (AAV1)...
June 15, 2018: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/29763577/comparison-of-the-regenerative-effects-of-platelet-rich-fibrin-and-plasma-rich-in-growth-factors-on-injured-peripheral-nerve-an-experimental-study
#10
Damla Torul, Mehmet Cihan Bereket, Mehmet Emin Onger, Gamze Altun
PURPOSE: The aim of this study was to investigate the effects of platelet-rich fibrin (PRF) and plasma rich in growth factors (PRGF) on peripheral nerve injury in the early period of healing. MATERIAL AND METHODS: Thirty Wistar albino rats were used in this study. Rats were divided into control (C), damaged (D), PRF, and PRGF groups. The left sciatic nerves of each group were identified as group C. Crush-type injury was performed on the right sciatic nerves of the D, PRF, and PRGF groups...
April 20, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29762123/identification-of-a-critical-sulfation-in-chondroitin-that-inhibits-axonal-regeneration
#11
Craig S Pearson, Caitlin P Mencio, Amanda C Barber, Keith R Martin, Herbert M Geller
The failure of mammalian CNS neurons to regenerate their axons derives from a combination of intrinsic deficits and extrinsic factors. Following injury, chondroitin sulfate proteoglycans (CSPGs) within the glial scar inhibit axonal regeneration, an action mediated by the sulfated glycosaminoglycan (GAG) chains of CSPGs, especially those with 4-sulfated (4S) sugars. Arylsulfatase B (ARSB) selectively cleaves 4S groups from the non-reducing ends of GAG chains without disrupting other, growth-permissive motifs...
May 15, 2018: ELife
https://www.readbyqxmd.com/read/29759730/citrate-chemistry-and-biology-for-biomaterials-design
#12
Chuying Ma, Ethan Gerhard, Di Lu, Jian Yang
Leveraging the multifunctional nature of citrate in chemistry and inspired by its important role in biological tissues, a class of highly versatile and functional citrate-based materials (CBBs) has been developed via facile and cost-effective polycondensation. CBBs exhibiting tunable mechanical properties and degradation rates, together with excellent biocompatibility and processability, have been successfully applied in vitro and in vivo for applications ranging from soft to hard tissue regeneration, as well as for nanomedicine designs...
May 4, 2018: Biomaterials
https://www.readbyqxmd.com/read/29756516/transplantation-of-a-peripheral-nerve-with-neural-stem-cells-plus-lithium-chloride-injection-promote-the-recovery-of-rat-spinal-cord-injury
#13
Li-Qun Zhang, Wen-Ming Zhang, Lingxiao Deng, Zi-Xing Xu, Wen-Bin Lan, Jian-Hua Lin
Transplantation of neural stem cells (NSCs) holds great potential for the treatment of spinal cord injury (SCI). However, transplanted NSCs poorly survive in the SCI environment. We injected NSCs into tibial nerve and transplanted tibial nerve into a hemisected spinal cord and investigated the effects of lithium chloride (LiCl) on the survival of spinal neurons, axonal regeneration, and functional recovery. Our results show that most of the transplanted NSCs expressed glial fibrillary acidic protein, while there was no obvious expression of nestin, neuronal nuclei, or acetyltransferase found in NSCs...
January 1, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29751848/differentiation-of-adipose-derived-stem-cells-into-schwann-cell-like-cells-through-intermittent-induction-potential-advantage-of-cellular-transient-memory-function
#14
Xun Sun, Yun Zhu, He-Yong Yin, Zhi-Yuan Guo, Feng Xu, Bo Xiao, Wen-Li Jiang, Wei-Min Guo, Hao-Ye Meng, Shi-Bi Lu, Yu Wang, Jiang Peng
BACKGROUND: Peripheral nerve injury (PNI) is a worldwide issue associated with severe social and economic burden. Autologous nerve grafting, the gold standard treatment for peripheral nerve defects, still has a number of technical limitations. Tissue engineering technology is a novel therapeutic strategy, and mesenchymal stromal cells (MSCs) are promising seed cells for nerve tissue engineering. However, the efficiency of traditional methods for inducing the differentiation of MSCs to Schwann cell-like cells (SCLCs) remains unsatisfactory...
May 11, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29750992/transcriptome-analysis-of-dorsal-root-ganglia-s-diabetic-neuropathy-reveals-mechanisms-involved-in-pain-and-regeneration
#15
Maria Carolina Pedro Athie, Andre Schwambach Vieira, Juliana Maia Teixeira, Gilson Gonçalves Dos Santos, Elayne Vieira Dias, Claudia Herrera Tambeli, Cesar Renato Sartori, Carlos A Parada
Peripheral diabetic neuropathy (DN) manifests in nearly 60% of diabetic patients, being pain its most debilitating symptom. Although electrophysiological and morphological aspects are well described, little is known about its development and progression, undermining effective therapies. Hyperglycemia and insulin signaling impairment are considered the triggering events of oxidative stress observed in the dying nerves, however there are still many gaps in the knowledge of intracellular plastic changes it generates...
May 8, 2018: Life Sciences
https://www.readbyqxmd.com/read/29749025/photobiomodulation-induces-antinociception-recovers-structural-aspects-and-regulates-mitochondrial-homeostasis-in-peripheral-nerve-of-diabetic-mice
#16
Victória Regina da Silva de Oliveira, Diego Pulzatto Cury, Laura Basílio Yamashita, Marcos Vinicius Esteca, Ii-Sei Watanabe, Yoko Fee Bergmann, Elaine Flamia Toniolo, Camila Squarzoni Dale
Diabetic Peripheral Neuropathy (DPN) is a nervous disorder caused by diabetes mellitus, affecting about 50% of patients in clinical medicine. Chronic pain is one of the major and most unpleasant symptoms developed by those patients, and conventional available treatments for the neuropathy, including the associated pain, are still unsatisfactory and benefit only a small number of patients. Photobiomodulation (PBM) has been gaining clinical acceptance once it is able to promote early nerve regeneration resulting in significant improvement peripheral nerves disabilities...
May 11, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29747821/gangliosides-in-axon-stability-and-regeneration
#17
Pablo H H Lopez, Bárbara Beatriz Báez
Gangliosides are a family of sialic acid-containing glycosphingolipids highly expressed in the nervous system of vertebrates. Over the last 25years, research has unmasked several of their neurobiological functions but the role of gangliosides in the nervous system remains not fully elucidated. Genetic disruption of genes for key enzymes involved in ganglioside biosynthesis led to the discovery of their diverse functions and highlighted the exquisite structural specificity required in this processes. In the nervous system, gangliosides regulate axonal caliber and organize ion channels at the nodes of Ranvier, a critical step to ensure fast conduction velocity of myelinated fibers...
2018: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/29746989/increased-expression-of-transcription-factor-sry-box-containing-gene-11-sox11-enhances-neurite-growth-by-regulating-neurotrophic-factor-responsiveness
#18
Michael P Jankowski, Lauren Miller, H Richard Koerber
The peripherally projecting axons of dorsal root ganglion (DRG) neurons readily regenerate after damage while their centrally projecting branches do not regenerate to the same degree after injury. One important reason for this inconsistency is the lack of pro-regeneration gene expression that occurs in DRG neurons after central injury relative to peripheral damage. The transcription factor SRY-Box containing gene 11 (Sox11) may be a crucial player in the regenerative capacity of axons as previous evidence has shown that it is highly upregulated after peripheral axon damage but not after central injury...
May 7, 2018: Neuroscience
https://www.readbyqxmd.com/read/29744840/microwave-assisted-synthesis-and-immunological-evaluation-of-self-assembling-peptide-vaccines
#19
C Brent Chesson, Rojelio Elias Alvarado, Jai S Rudra
Self-assembling peptides spontaneously associate into functional supramolecular scaffolds, which have found numerous biomedical applications. These molecular assemblies have applications in nerve regeneration, wound healing, and both prophylactic and therapeutic vaccination. They can also be useful tools for proliferation assays, sustained culture of difficult cell lines, or activation of cell lines for immunoassays. This protocol will describe the basic peptide synthesis and purification of model self-assembling peptide immunogen and methods for vaccinating mice, collecting lymph nodes, and stimulating cells ex vivo...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29742495/progressive-degeneration-and-inhibition-of-peripheral-nerve-regeneration-in-the-sod1-g93a-mouse-model-of-amyotrophic-lateral-sclerosis
#20
Binbin Deng, Wenjing Lv, Weisong Duan, Yakun Liu, Zhongyao Li, Yanqin Ma, Guisen Zhang, Xueqin Song, Can Cui, Xiaoming Qi, Yuan Li, Chunyan Li
BACKGROUND: Myelination, degeneration and regeneration are implicated in crucial responses to injury in the peripheral nervous system. Considering the progression of amyotrophic lateral sclerosis (ALS), we used the superoxide dismutase 1 (SOD1)-G93A transgenic mouse model of ALS to investigate the effects of mutant SOD1 on the peripheral nerves. METHODS: Changes in peripheral nerve morphology were analyzed in SOD1 mutant mice at various stages of the disease by toluidine blue staining and electron microscopy (EM)...
May 4, 2018: Cellular Physiology and Biochemistry
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