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Nerve Regeneration

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https://www.readbyqxmd.com/read/28927918/the-safety-of-irreversible-electroporation-on-nerves-adjacent-to-treated-tumors
#1
Xiaomei Luo, Zilin Qin, Huimin Tao, Jian Shi, Gang Fang, Zhonghai Li, Xulong Zhou, Jibing Chen, Kecheng Xu, Jianying Zeng, Lizhi Niu
OBJECTIVES: To evaluate the safety of irreversible electroporation (IRE) on the sciatic nerve after IRE ablation of adjacent tumor. METHODS: and analysis In this study, VX2 tumors were implanted adjacent to the sciatic nerves in 26 New Zealand white rabbits. The rabbits were divided into three groups 10 days after implantation, with two treatment groups of ten rabbits each and a control group of six rabbits. In one of the treatment groups (IRE-S group), the rabbits underwent ablation with a single IRE application, and in the other group (IRE-D group) the rabbits underwent two IRE applications...
September 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28922518/accelerated-epithelialization-and-improved-wound-healing-metrics-in-porcine-full-thickness-wounds-transplanted-with-full-thickness-skin-micrografts
#2
Christina L Rettinger, John L Fletcher, Anders H Carlsson, Rodney K Chan
Split-thickness skin grafting (STSG) is the current gold standard for treatment of extensive burn and traumatic skin injuries. However, STSG is limited by donor-site morbidity and availability, and often leads to scarring and wound contracture. Furthermore, these thin grafts lack dermal elements such as nerves and adnexa which are important in recapitulating normal skin function. Methods of fractional skin replacement either as minced STSGs or microscopic skin tissue columns (MSTCs) have been proposed, though these techniques have not been fully-characterized and lack evidence of regenerated adnexal structures...
September 18, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28917662/successful-optic-nerve-regeneration-in-the-senescent-zebrafish-despite-age-related-decline-of-cell-intrinsic-and-extrinsic-response-processes
#3
Jessie Van Houcke, Ilse Bollaerts, Emiel Geeraerts, Benjamin Davis, An Beckers, Inge Van Hove, Kim Lemmens, Lies De Groef, Lieve Moons
Dysfunction of the central nervous system (CNS) in neurodegenerative diseases or after brain lesions seriously affects life quality of a growing number of elderly, since the adult CNS lacks the capacity to replace or repair damaged neurons. Despite intensive research efforts, full functional recovery after CNS disease and/or injury remains challenging, especially in an aging environment. As such, there is a rising need for an aging model in which the impact of aging on successful regeneration can be studied...
August 24, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28915971/genotrophic-effect-of-neurotrophins-restart-of-%C3%AE-cell-regeneration-in-diabetes-mellitus
#4
Mariyana G Hristova
Type 2 diabetes mellitus is an epidemic worldwide and a proved risk factor for cardiovascular complications. In 89% of the cases, it deals, in fact, with metabolic syndrome of multifactorial etiopathogenesis. This paradigm has been generalized by the neurotrophic theory emphasizing the role of hyponeurotrophinemia of key factor. Both type 2 diabetes mellitus and metabolic syndrome are characterized by insulin resistance and pancreatic β-cell damage. Cyclic keeping the fast enhances plasma neurotrophin levels...
September 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28915233/the-utility-of-stem-cells-in-pediatric-urinary-bladder-regeneration
#5
REVIEW
Philip M Iannaccone, Vasil Galat, Matthew I Bury, Yongchao C Ma, Arun K Sharma
Pediatric patients with a neurogenic urinary bladder caused by developmental abnormalities including spina bifida exhibit chronic urological problems. Surgical management in the form of enterocystoplasty is used to enlarge the bladder but is associated with significant clinical complications. Thus, alternative methods to enterocystoplasty have been explored through the incorporation of stem cells with tissue engineering strategies. Within the context of this review, we will examine the use of bone marrow stem cells and induced pluripotent stem cells (iPSCs) as they relate to bladder regeneration at the anatomic and molecular levels...
September 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28914740/the-role-of-precisely-matching-fascicles-in-the-quick-recovery-of-nerve-function-in-long-peripheral-nerve-defects
#6
Liwei Yan, Zhi Yao, Tao Lin, Qingtang Zhu, Jian Qi, Liqiang Gu, Jintao Fang, Xiang Zhou, Xiaolin Liu
Peripheral nerve injury therapy in the clinic remains less than satisfactory. The gold standard of treatment for long peripheral nerve defects is autologous nerve grafts; however, numerous clinical complications are associated with this treatment. As tissue engineering has developed, tissue-engineered nerve grafts (TENGs) have shown potential applications as alternatives to autologous nerve grafts. To verify the important role of the biomimetic pathway of fascicle design in TENGs, we designed an animal model to study the role of the precise matching of fascicles in the effectiveness of nerve function recovery...
October 18, 2017: Neuroreport
https://www.readbyqxmd.com/read/28914336/patterns-of-cutaneous-nerve-fibre-loss-and-regeneration-in-type-2-diabetes-with-painful-and-painless-polyneuropathy
#7
Gidon J Bönhof, Alexander Strom, Sonja Püttgen, Bernd Ringel, Jutta Brüggemann, Kálmán Bódis, Karsten Müssig, Julia Szendroedi, Michael Roden, Dan Ziegler
AIMS/HYPOTHESIS: The determinants and mechanisms of the development of diabetic sensorimotor polyneuropathy as a painful (DSPN+p) or painless (DSPN-p) entity remain unclear. We examined the degree of cutaneous nerve fibre loss and regeneration in individuals with type 2 diabetes with DSPN+p or DSPN-p compared with individuals with recent-onset type 2 diabetes and corresponding healthy volunteers. METHODS: In this cross-sectional study, skin biopsies taken from the distal lateral calf were obtained from individuals with recent-onset type 2 diabetes (n = 32) from the German Diabetes Study, with DSPN+p (n = 34) and DSPN-p (n = 32) from the PROPANE study, and volunteers with normal glucose tolerance (n = 50)...
September 15, 2017: Diabetologia
https://www.readbyqxmd.com/read/28912843/microrna-210-contributes-to-peripheral-nerve-regeneration-through-promoting-the-proliferation-and-migration-of-schwann-cells
#8
Xiaona Zhang, Xu Gong, Jinpeng Qiu, Yang Zhang, Fengyan Gong
Peripheral nerve injury impacts the daily life of affected individuals. MicroRNA (miR)-210 is a multifunctional miR and has effects on the proliferation, migration and differentiation of cells. However, whether miR-210 has effects on peripheral nerve regeneration has remained elusive. In the present study, the miR-210 levels in a rat model of sciatic nerve injury were evaluated by reverse-transcription quantitative PCR and the effects of miR-210 on the proliferation and migration of Schwann cells were explored...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28912156/neutrophils-are-critical-for-myelin-removal-in-a-peripheral-nerve-injury-model-of-wallerian-degeneration
#9
Jane A Lindborg, Matthias Mack, Richard E Zigmond
Wallerian degeneration (WD) is considered an essential preparatory stage to the process of axonal regeneration. In the peripheral nervous system, infiltrating monocyte-derived macrophages that utilize the chemokine receptor CCR2 to gain entry to injured tissues from the bloodstream, are purportedly necessary for efficient WD. However, our lab has previously reported that myelin clearance in the injured sciatic nerve proceeds unhindered in the Ccr2(-/-) mouse model. Here, we extensively characterize WD in male Ccr2(-/-) mice and identify a compensatory mechanism of WD that is facilitated primarily by neutrophils...
September 14, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28911884/anti-vegf-treatment-improves-neurological-function-in-tumors-of-the-nervous-system
#10
REVIEW
Na Zhang, Jie Chen, Gino Ferraro, Limeng Wu, Meenal Datta, Rakesh K Jain, Scott R Plotkin, Anat Stemmer-Rachamimov, Lei Xu
Research of various diseases of the nervous system has shown that VEGF has direct neuroprotective effects in the central and peripheral nervous systems, and indirect effects on improving neuronal vessel perfusion which leads to nerve protection. In the tumors of the nervous system, VEGF plays a critical role in tumor angiogenesis and tumor progression. The effect of anti-VEGF treatment on nerve protection and function has been recently reported - by normalizing the tumor vasculature, anti-VEGF treatment is able to relieve nerve edema and deliver oxygen more efficiently into the nerve, thus reducing nerve damage and improving nerve function...
September 11, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28910445/corneal-epithelium-derived-neurotrophic-factors-promote-nerve-regeneration
#11
Guohu Di, Xia Qi, Xiaowen Zhao, Songmei Zhang, Patrik Danielson, Qingjun Zhou
Purpose: To explore the neurotrophic factor expression in corneal epithelium and evaluate their effects on the trigeminal ganglion (TG) neurite outgrowth and corneal nerve regeneration in mice. Methods: The expression of neurotrophic factors was compared among the intact, regenerating, and regenerated mouse corneal epithelium. Mouse primary TG neurons were treated with the conditioned medium of mouse corneal epithelial cells. Nerve growth factor (NGF) neutralizing antibody and glial cell-derived neurotrophic factor (GDNF) neutralizing antibody were used to evaluate their roles in mouse corneal nerve regeneration and TG neurite outgrowth...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28904214/after-nerve-injury-lineage-tracing-shows-that-myelin-and-remak-schwann-cells-elongate-extensively-and-branch-to-form-repair-schwann-cells-which-shorten-radically-on-remyelination
#12
Jose A Gomez-Sanchez, Kjara S Pilch, Milou van der Lans, Shaline V Fazal, Cristina Benito, Laura J Wagstaff, Rhona Mirsky, Kristjan R Jessen
There is consensus that, distal to peripheral nerve injury, myelin and Remak cells reorganize to form cellular columns, Bungner's bands, which are indispensable for regeneration. However, knowledge of the structure of these regeneration tracks has not advanced for decades and the structure of the cells that form them, denervated or repair Schwann cells, remains obscure. Furthermore, the origin of these cells from myelin and Remak cells and their ability to give rise to myelin cells after regeneration has not been demonstrated directly, although these conversions are believed to be central to nerve repair...
September 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28902937/inside-out-and-standard-vein-grafts-associated-with-platelet-rich-plasma-prp-in-sciatic-nerve-repair-a-histomorphometric-study
#13
José Sidney Roque, Karina Torres Pomini, Rogério Leone Buchaim, Daniela Vieira Buchaim, Jesus Carlos Andreo, Domingos Donizeti Roque, Antonio de Castro Rodrigues, Geraldo Marco Rosa, Luis Henrique Rapucci Moraes, Fausto Viterbo
Purpose: To evaluated the tubulization technique with standard and inside-out vein, filled or not with platelet-rich plasma (PRP), in sciatic nerve repair. Methods: Seventy male Wistar rats were randomly divided into five groups: IOVNF (Inside-Out Vein with No Filling); IOVPRP (Inside-Out Vein filled with PRP); SVNF (Standard Vein with No Filling); SVPRP (Standard Vein filled with PRP); Sham (Control). The left external jugular vein was used as graft in a 10 mm nervous gap...
August 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28901688/poly-glycerol-sebacate-combined-with-chondroitinase-abc-promotes-spinal-cord-repair-in-rats
#14
Qi Pan, Yan Guo, Fanyong Kong
This study was to investigate the feasibility of PGS combined with ChABC for repairing the transection of spinal cords (TSC) in rats. A thoracic 10 (T10) TSC model of rats was employed. The effects of PGS with ChABC on the morphology and histological structure of the spinal cords, Basso, Beattie, Bresnahan (BBB) scores, and the expression of GAP-43 and NF-200 were comparatively studied. The BBB scores indicated that all rats with TSC were paralyzed immediately after surgery and then recovered hind limb movement gradually, but did not fully recover until the end of week 12...
September 13, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28901252/the-origin-and-identification-of-mesenchymal-stem-cells-in-teeth-from-odontogenic-to-non-odontogenic
#15
Dixin Cui, Hongyu Li, Mian Wan, Yiran Peng, Xin Xu, Xuedong Zhou, Liwei Zheng
Mesenchymal stem cells (MSCs) in teeth have been exploited as vital seed cells for stem cell-based dental medicine. To date, several mesenchymal stem cell populations originated from odontogenic tissue have been isolated and characterized by their expression of MSC surface markers and capacity of multi-lineage differentiation, including dental pulp stem cells (DPSCs), stem cells from human exfoliated deciduous teeth (SHED), stem cells from apical papilla (SCAP) and so on. However, their identity in vivo remains elusive, which hinders further understanding of their application in stem cell-based tooth regeneration...
September 13, 2017: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28894816/evaluation-of-peripheral-nerve-regeneration-through-biomaterial-conduits-via-micro-ct-imaging
#16
Sarah K Pixley, Tracy M Hopkins, Kevin J Little, David B Hom
OBJECTIVE: Hollow nerve conduits made of natural or synthetic biomaterials are used clinically to aid regeneration of peripheral nerves damaged by trauma or disease. To support healing, conduit lumen patency must be maintained until recovery occurs. New methods to study conduit structural integrity would provide an important means to optimize conduits in preclinical studies. We explored a novel combined technique to examine structural integrity of two types of nerve conduits after in vivo healing...
December 2016: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28894753/evaluation-of-epigallocatechin-3-gallate-modified-collagen-membrane-and-concerns-on-schwann-cells
#17
Chenyu Chu, Jia Deng, Cong Cao, Yi Man, Yili Qu
Collagen is an essential component of the extracellular matrix (ECM) and is a suitable material for nerve repair during tissue remodeling for fracture repair. Epigallocatechin-3-gallate (EGCG), an extract of green tea, shows various biological activities that are beneficial to nerve repair. Here, we developed modified collagen containing different concentrations of EGCG (0.0064%, 0.064%, and 0.64%, resp.) to induce Schwann cell proliferation and differentiation. Cell Counting Kit-8 test, live/dead assay, and SEM showed that collagen cross-linked by EGCG induced Schwann cell proliferation...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28894606/corneal-nerve-regeneration-after-self-retained-cryopreserved-amniotic-membrane-in-dry-eye-disease
#18
Thomas John, Sean Tighe, Hosam Sheha, Pedram Hamrah, Zeina M Salem, Anny M S Cheng, Ming X Wang, Nathan D Rock
PURPOSE: To evaluate the efficacy of self-retained cryopreserved amniotic membrane (CAM) in promoting corneal nerve regeneration and improving corneal sensitivity in dry eye disease (DED). METHODS: In this prospective randomized clinical trial, subjects with DED were randomized to receive CAM (study group) or conventional maximum treatment (control). Changes in signs and symptoms, corneal sensitivity, topography, and in vivo confocal microscopy (IVCM) were evaluated at baseline, 1 month, and 3 months...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28891122/nerve-speci%C3%AF-c-xenogeneic-extracellular-matrix-hydrogel-promotes-recovery-following-peripheral-nerve-injury
#19
Travis A Prest, Eric Yeager, Samuel T LoPresti, Emilija Zygelyte, Matthew J Martin, Longying Dong, Alexis Gibson, Oluyinka O Olutoye, Bryan N Brown, Jonathan Cheetham
Peripheral nerve possesses the inherent ability to regrow and recover following injury. However, nerve regeneration is often slow and incomplete due to limitations associated with the local microenvironment during the repair process. Manipulation of the local microenvironment at the site of nerve repair, therefore, represents a significant opportunity for improvement in downstream outcomes. Macrophages and Schwann cells play a key role in the orchestration of early events after peripheral nerve injury. We describe the production, characterization, and use of an injectable, peripheral nerve-specific extracellular matrix-based hydrogel (PNSECM) for promoting modulation of the local macrophage and Schwann cell responses at the site of nerve repair in a rodent model of sciatic nerve injury...
September 11, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28890869/multifunctional-biomimetic-spinal-cord-new-approach-to-repair-spinal-cord-injuries
#20
REVIEW
Yang Liu, Qian Li, Bin Zhang, De-Xiang Ban, Shi-Qing Feng
The incidence of spinal cord injury (SCI) has been gradually increasing, and the treatment has troubled the medical field all the time. Primary and secondary injuries ultimately lead to nerve impulse conduction block. Microglia and astrocytes excessively accumulate and proliferate to form the glial scar. At present, to reduce the effect of glial scar on nerve regeneration is a hot spot in the research on the treatment of SCI. According to the preliminary experiments, we would like to provide a new bionic spinal cord to reduce the negative effect of glial scar on nerve regeneration...
August 20, 2017: World Journal of Experimental Medicine
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