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https://www.readbyqxmd.com/read/28742810/effect-of-calcium-electroporation-in-combination-with-metformin-in-vivo-and-correlation-between-viability-and-intracellular-atp-level-after-calcium-electroporation-in-vitro
#1
Stine Krog Frandsen, Julie Gehl
BACKGROUND: Calcium electroporation is a new experimental anti-cancer treatment where calcium is internalized into cells by application of short, high voltage pulses. Calcium electroporation has been shown to induce tumor necrosis associated with ATP depletion while the effect on normal fibroblasts was limited when investigated in a 3D in vitro spheroid model. We aimed to investigate the effect of calcium electroporation in combination with metformin, a drug that affects intracellular ATP level...
2017: PloS One
https://www.readbyqxmd.com/read/28742709/prospective-evaluation-of-precision-multimodal-gallbladder-surgery-navigation-virtual-reality-near-infrared-fluorescence-and-x-ray-based-intraoperative-cholangiography
#2
Michele Diana, Luc Soler, Vincent Agnus, Antonio D'Urso, Michel Vix, Bernard Dallemagne, Vanina Faucher, Catherine Roy, Didier Mutter, Jacques Marescaux, Patrick Pessaux
OBJECTIVE: We aimed to prospectively evaluate NIR-C, VR-AR, and x-ray intraoperative cholangiography (IOC) during robotic cholecystectomy. BACKGROUND: Near-infrared cholangiography (NIR-C) provides real-time, radiation-free biliary anatomy enhancement. Three-dimensional virtual reality (VR) biliary anatomy models can be obtained via software manipulation of magnetic resonance cholangiopancreatography, enabling preoperative VR exploration, and intraoperative augmented reality (AR) navigation...
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28742252/augmented-and-doubly-robust-g-estimation-of-causal-effects-under-a-structural-nested-failure-time-model
#3
Karl Mertens, Stijn Vansteelandt
Structural nested failure time models (SNFTMs) are models for the effect of a time-dependent exposure on a survival outcome. They have been introduced along with so-called G-estimation methods to provide valid adjustment for time-dependent confounding induced by time-varying variables. Adjustment for informative censoring in SNFTMs is possible via inverse probability of censoring weighting (IPCW). In the presence of considerable dropout, this can imply substantial information loss and consequently imprecise effect estimates...
July 25, 2017: Biometrics
https://www.readbyqxmd.com/read/28742159/%C3%AE-adrenergic-signaling-broadly-contributes-to-ltp-induction
#4
Joanna Jȩdrzejewska-Szmek, Vincent Luczak, Ted Abel, Kim T Blackwell
Long-lasting forms of long-term potentiation (LTP) represent one of the major cellular mechanisms underlying learning and memory. One of the fundamental questions in the field of LTP is why different molecules are critical for long-lasting forms of LTP induced by diverse experimental protocols. Further complexity stems from spatial aspects of signaling networks, such that some molecules function in the dendrite and some are critical in the spine. We investigated whether the diverse experimental evidence can be unified by creating a spatial, mechanistic model of multiple signaling pathways in hippocampal CA1 neurons...
July 24, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28741434/robot-applied-resistance-augments-the-effects-of-body-weight-supported-treadmill-training-on-stepping-and-synaptic-plasticity-in-a-rodent-model-of-spinal-cord-injury
#5
Erika Hinahon, Christina Estrada, Lin Tong, Deborah S Won, Ray D de Leon
BACKGROUND: The application of resistive forces has been used during body weight-supported treadmill training (BWSTT) to improve walking function after spinal cord injury (SCI). Whether this form of training actually augments the effects of BWSTT is not yet known. OBJECTIVE: To determine if robotic-applied resistance augments the effects of BWSTT using a controlled experimental design in a rodent model of SCI. METHODS: Spinally contused rats were treadmill trained using robotic resistance against horizontal (n = 9) or vertical (n = 8) hind limb movements...
July 1, 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/28741335/cardiopulmonary-bypass-time-every-minute-counts
#6
Sudharsan Madhavan, Siew-Pang Chan, Wei-Chuan Tan, Jolane Eng, Bowen Li, Hai-Dong Luo, Leok-Kheng K Teoh
BACKGROUND: This study was conducted to examine the impact of CPB times on post-operative outcomes. We sought to determine the optimum cut-offs of CPB per graft time and cumulative CPB time and their predictive accuracy for mortality in conjunction with EuroSCORE II. METHODS: The de-identified data of 1,960 patients who had undergone isolated on-pump CABG from 2009 to 2014 were analyzed. The risk strata of CPB/graft and cumulative CPB times, identified with a decision tree, were added into an augmented model for predicting short- and intermediate-term post-operative clinical events...
July 24, 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28741276/the-use-of-a-biphasic-calcium-phosphate-in-a-maxillary-sinus-floor-elevation-procedure-a-clinical-radiological-histological-and-histomorphometric-evaluation-with-9-and-12-month-healing-times
#7
W F Bouwman, N Bravenboer, J W F H Frenken, C M Ten Bruggenkate, E A J M Schulten
BACKGROUND: This study evaluates the clinical, radiological, histological, and histomorphometric aspects of a fully synthetic biphasic calcium phosphate (BCP) (60% hydroxyapatite and 40% ß-tricalcium phosphate), used in a human maxillary sinus floor elevation (MSFE) procedure with 9- and 12-month healing time. METHODS: A unilateral MSFE procedure, using 100% BCP, was performed in two series of five patients with healing times of 9 and 12 months respectively. Clinical and radiological parameters were measured up to 5 years postoperatively...
December 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28741230/new-therapeutic-strategies-for-lewy-body-dementias
#8
REVIEW
Latha Velayudhan, Dominic Ffytche, Clive Ballard, Dag Aarsland
This article reviews current treatment strategies and recent advances for the Lewy body dementias (LBDs). Current available symptom treatment strategies are based on monoaminergic, cholinergic and glutaminergic neurotransmitter systems. Relatively robust evidence exists for cholinesterase inhibitors for cognitive impairment in LBD and in Parkinson's disease for antidepressants, clozapine and recently pimavanserin for psychosis. interpidine (RVT 101) and nelotanserin are currently under investigation. Non-pharmacological interventions, such as cognitive stimulation, physical exercises and neuromodulation strategies, may be useful in Parkinson's disease but have not yet been tested in dementias...
September 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28741192/parastomal-hernia-repair-with-a-3d-funnel-intraperitoneal-mesh-device-and-same-sided-stoma-relocation-results-of-56-cases
#9
Ines Fischer, Helwig Wundsam, Martin Mitteregger, Gernot Köhler
BACKGROUND: Parastomal hernias (PSHs) are a common and challenging issue. In previous studies, three-dimensional (3D) funnel mesh devices have been used successfully for the repair of PSHs. METHODS: We performed an analysis of prospectively collected data of patients who underwent a same-sided stoma reposition with 3D funnel-shaped mesh augmentation in intraperitoneal (IPOM) position at our department between the years of 2012 and 2015. Primary outcome parameters were intra- and postoperative surgical complications and recurrence rate during the follow-up period...
July 24, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28740855/aldose-reductase-inhibitor-protects-against-hyperglycemic-stress-by-activating-nrf2-dependent-antioxidant-proteins
#10
Kirtikar Shukla, Pabitra Bikash Pal, Himangshu Sonowal, Satish K Srivastava, Kota V Ramana
We have shown earlier that pretreatment of cultured cells with aldose reductase (AR) inhibitors prevents hyperglycemia-induced mitogenic and proinflammatory responses. However, the effects of AR inhibitors on Nrf2-mediated anti-inflammatory responses have not been elucidated yet. We have investigated how AR inhibitor fidarestat protects high glucose- (HG-) induced cell viability changes by increasing the expression of Nrf2 and its dependent phase II antioxidant enzymes. Fidarestat pretreatment prevents HG (25 mM)-induced Thp1 monocyte viability...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28740769/simply-do-not-go-snowboarding-2-weeks-after-augmentation
#11
Karl Schwaiger, Elisabeth Russe, Michaela Hladik, René Kaplan, Frederik DeMeyer, Klemens Heinrich, Valentin Zimmermann, Gottfried Wechselberger
No abstract text is available yet for this article.
June 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28740625/pulmonary-valve-replacement-in-patients-with-corrected-tetralogy-of-fallot
#12
Fotios M Mitropoulos, Meletios A Kanakis, Christos Ntellos, Constantinos Loukas, Periklis Davlouros, Theophili Kousi, Andrew C Chatzis
Introduction: Development of pulmonary insufficiency in patients with surgically corrected tetralogy of Fallot (TOF) may lead to severe right heart failure with serious consequences. We herein present our experience with pulmonary valve replacement (PVR) in these patients. Methods: From 2005-2013, 99 consecutive patients (71 males/28 females, mean age 38±8 years), underwent PVR after 7 to 40 (mean 29 ± 8) years from the initial correction. Seventy nine of the symptomatic patients presented in NYHA II, 14 in III and 2 in IV...
2017: Journal of Cardiovascular and Thoracic Research
https://www.readbyqxmd.com/read/28740456/carotid-artery-stiffness-digital-endothelial-function-and-coronary-calcium-in-patients-with-essential-thrombocytosis-free-of-overt-atherosclerotic-disease
#13
Matjaz Vrtovec, Ajda Anzic, Irena Preloznik Zupan, Katja Zaletel, Ales Blinc
BACKGROUND: Patients with myeloproliferative neoplasms (MPNs) are at increased risk for atherothrombotic events. Our aim was to determine if patients with essential thrombocytosis (ET), a subtype of MPNs, free of symptomatic atherosclerosis, have greater carotid artery stiffness, worse endothelial function, greater coronary calcium and carotid plaque burden than control subjects. PATIENTS AND METHODS: 40 ET patients without overt vascular disease, and 42 apparently healthy, age and sex-matched control subjects with comparable classical risk factors for atherosclerosis and Framingham risk of coronary disease were enrolled...
June 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/28739829/inherent-oxidative-stress-in-lewis-rat-is-associated-with-resistance-to-toxoplasmosis
#14
William H Witola, Chi Yong Kim, Xuejin Zhang
The course of Toxoplasma gondii infection in rats closely resembles that in humans. However, compared to the Brown Norway (BN) rat, the Lewis (LEW) rat is extremely resistant to T. gondii infection. Thus, we performed RNA sequencing analysis of the LEW versus BN rat, with or without T. gondii infection, in order to unravel molecular factors directing robust and rapid early T. gondii-killing mechanisms in the LEW rat. We found that, compared to the uninfected BN rat, the uninfected LEW rat has inherently higher transcript levels of cytochrome enzymes [Cyp2d3, Cyp2d5 and Cybrd1 that catalyze generation of reactive oxygen species (ROS)], with concomitant higher levels of ROS...
July 24, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28739690/nicotine-exposure-augments-renal-toxicity-of-5-aza-cytidine-through-p66shc-prevention-by-resveratrol
#15
Istvan Arany, Samuel Hall, Amir Faisal, Mehul Dixit
BACKGROUND/AIM: We have shown that either chronic nicotine (NIC) exposure or 5-aza-cytidine (AZA) augments oxidative stress-dependent injury through stimulating p66shc in renal cells. Hence, NIC could exacerbate adverse effects of AZA while antioxidants such as resveratrol (RES) could prevent it. MATERIALS AND METHODS: Renal proximal tubule cells (NRK52E) were treated with 20 μM RES prior to 200 μM NIC plus 100 nM AZA and cell injury (LDH release) was determined...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739636/immunoassay-for-human-serum-erythroferrone
#16
Tomas Ganz, Grace Jung, Arash Naeim, Yelena Ginzburg, Zahra Pakbaz, Patrick B Walter, Léon Kautz, Elizabeta Nemeth
Erythroferrone (ERFE) is a glycoprotein hormone secreted by erythroblasts in response to stimulation by erythropoietin. We previously demonstrated that ERFE mRNA expression and serum protein concentration increase in mice subjected to hemorrhage or erythropoietin therapy, that ERFE acts on hepatocytes to suppress hepcidin, and that the resulting decrease in hepcidin augments iron delivery for intensified erythropoiesis. We also showed that ERFE contributes to pathological hepcidin suppression and iron overload in mice with non-transfused β-thalassemia...
July 24, 2017: Blood
https://www.readbyqxmd.com/read/28739610/silicone-implant-incompatibility-syndrome-siis-in-a-57-year-old-woman-with-unilateral-silicone-breast-implant
#17
Juliane Schierbeck, Jesper Rømhild Davidsen, Sanne Grindsted Nielsen, Camilla Bille
Since the 1960s, silicone implants have been used for breast augmentations, both cosmetically and in reconstructive surgery. Tissue exposed to silicone can react with multiple adverse advents. Autoimmune/inflammatory syndrome induced by adjuvants due to silicone exposure from ruptured silicone implants can lead to different interstitial lung manifestations predominantly with granuloma evolvement, leading to the so-called silicone implant incompatibility syndrome (SIIS). This case describes a 57-year-old woman with multiple lung infiltrations and a left-sided breast implant...
July 24, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28739500/breast-implant-capsule-associated-squamous-cell-carcinoma-a-report-of-two-cases
#18
Daniel L Olsen, Gary L Keeney, Beiyun Chen, Daniel W Visscher, Jodi M Carter
The use of prosthetic implants for breast augmentation has become commonplace. While implants do not increase the risk of conventional mammary carcinoma, they are rarely associated with anaplastic large cell lymphoma. We report two cases of breast implant capsule-associated squamous cell carcinoma with poor clinical outcomes. Both patients (56-year-old female and 81-year-old female) had long-standing implants (>25years) and presented with acute unilateral breast enlargement. In both cases, squamous cell carcinoma arose in (focally dysplastic) squamous epithelium-lined breast implant capsules, and widely invaded surrounding breast parenchyma or chest wall...
July 21, 2017: Human Pathology
https://www.readbyqxmd.com/read/28739494/amblyomma-maculatum-secis-binding-protein-2-and-putative-selenoprotein-p-are-indispensable-for-pathogen-replication-and-tick-fecundity
#19
Khemraj Budachetri, Gary Crispell, Shahid Karim
Selenium, a vital trace element, is incorporated into selenoproteins to produce selenocysteine. Our previous studies have revealed an adaptive co-evolutionary process that has enabled the spotted fever-causing tick-borne pathogen Rickettsia parkeri to survive by manipulating an antioxidant defense system associated with selenium, which includes a full set of selenoproteins and other antioxidants in ticks. Here, we conducted a systemic investigation of SECIS binding protein 2 (SBP2) and putative selenoprotein P (SELENOP) by transcript silencing in adult female Gulf-coast ticks (Amblyomma maculatum)...
July 21, 2017: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28739433/pain-management-the-rising-role-of-interventional-oncology
#20
D Filippiadis, S Tutton, A Kelekis
Patients with early or metastatic cancer may suffer from pain of different origins. The vast majority of these patients are not adequately treated by means of systemic analgesia and radiotherapy. Percutaneous neurolysis is performed using chemical agents or thermal energy upon sympathetic nervous system plexus for pain reduction and life quality improvement. Ablation and vertebral augmentation are included in clinical guidelines for metastatic disease. As far as the peripheral skeleton is concerned bone augmentation and stabilization can be performed by means of cement injection either solely performed or in combination to cannulated screws or other metallic or peek implants...
July 21, 2017: Diagnostic and Interventional Imaging
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