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https://www.readbyqxmd.com/read/28340371/walking-adaptability-assessments-with-the-interactive-walkway-between-systems-agreement-and-sensitivity-to-task-and-subject-variations
#1
Daphne J Geerse, Bert H Coolen, Melvyn Roerdink
The ability to adapt walking to environmental circumstances is an important aspect of walking, yet difficult to assess. The Interactive Walkway was developed to assess walking adaptability by augmenting a multi-Kinect-v2 10-m walkway with gait-dependent visual context (stepping targets, obstacles) using real-time processed markerless full-body kinematics. In this study we determined Interactive Walkway's usability for walking-adaptability assessments in terms of between-systems agreement and sensitivity to task and subject variations...
March 2, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28340361/hdl-inhibits-saturated-fatty-acid-mediated-augmentation-of-innate-immune-responses-in-endothelial-cells-by-a-novel-pathway
#2
Wei-Yang Zhang, Daniel A Franco, Eric Schwartz, Karen D'Souza, Sheetal Karnick, Peter D Reaven
BACKGROUND AND AIMS: Peripheral insulin resistance is associated with several metabolic abnormalities, including elevated serum fatty acids that contribute to vascular injury and atherogenesis. Our goals were to examine whether saturated fatty acids can modify innate immune responses to subclinical concentrations of lipopolysaccharide (LPS) in endothelial cells, and to explore the underlying pathway and determine whether it is modified by high density lipoprotein (HDL) and other factors commonly altered in insulin resistance...
September 8, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/28339788/intravenous-dendritic-cell-administration-enhances-suppression-of-lung-metastasis-induced-by-carbon-ion-irradiation
#3
Ken Ando, Hidetoshi Fujita, Akihiro Hosoi, Liqiu Ma, Masaru Wakatsuki, Ken-Ichiro Seino, Kazuhiro Kakimi, Takashi Imai, Takashi Shimokawa, Takashi Nakano
Carbon-ion radiotherapy (CIRT) is an advanced radiotherapy and has achieved good local control, even in tumors that are resistant to conventional photon beam radiotherapy (PBRT). However, distant metastasis control is an important issue. Recently, the combination of radiotherapy and immunotherapy has attracted the attention. In immunotherapy, dendritic cells (DCs) play a pivotal role in the anti-tumor immune system. However, the mechanisms underlying the combination therapy of DCs and radiotherapy have been unclear...
February 27, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28339742/topiramate-modulates-post-infarction-inflammation-primarily-by-targeting-monocytes-or-macrophages
#4
Zhaohui Wang, Shiyuan Huang, Yuling Sheng, Xu Peng, Hui Liu, Nan Jin, Jun Cai, Yanwen Shu, Ting Li, Ping Li, Cheng Fan, Xiaofan Hu, Wenyong Zhang, Rui Long, Ya You, Caihong Huang, Yi Song, Chunhua Xiang, Jue Wang, Yong Yang, Kun Liu
Aims: Monocytes/macrophages response plays a key role in post-infarction inflammation that contributes greatly to post-infarction ventricular remodeling and cardiac rupture. Therapeutic targeting of the GABAA receptor, which is enriched in monocytes/macrophages but not expressed in the myocardium, may be possible after myocardial infarction. Methods and results: After MI was induced by ligation of the coronary artery, C57BL/6 mice were intraperitoneally administered with one specific agonist or antagonist of the GABAA receptor (topiramate or bicuculline), in the setting of presence or depletion of monocytes/macrophages...
February 17, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28339741/shear-stress-regulated-mir-27b-controls-pericyte-recruitment-by-repressing-sema6a-and-sema6d
#5
Shemsi Demolli, Anuradha Doddaballapur, Kavi Devraj, Konstantin Stark, Yosif Manavski, Annekathrin Eckart, Christoph Zehendner, Tina Lucas, Thomas Korff, Markus Hecker, Steffen Massberg, Stefan Liebner, David Kaluza, Reinier A Boon, Stefanie Dimmeler
Aims: Vessel maturation involves the recruitment of mural cells such as pericytes and smooth muscle cells. Laminar shear stress is a major trigger for vessel maturation, but the molecular mechanisms by which shear stress affects recruitment of pericytes are unclear. MicroRNAs (miRs) are small non-coding RNAs, which post-transcriptionally control gene expression. The aim of the present study was to unveil the mechanism by which shear stress-regulated microRNAs contribute to vessel maturation...
February 23, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28339622/augmented-qrs-notching-and-macroscopic-t-wave-alternans-preceding-polymorphic-ventricular-tachycardia-in-a-patient-with-electrical-storm
#6
Shingo Minatoguchi, Nobuhiro Takasugi, Tomoki Kubota, Hiroaki Ushikoshi, Kazuhiko Nishigaki, Shinya Minatoguchi
No abstract text is available yet for this article.
February 17, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28339593/selective-pharmacological-augmentation-of-hippocampal-activity-produces-a-sustained-antidepressant-like-response-without-abuse-related-or-psychotomimetic-effects
#7
Flavia R Carreno, Gregory T Collins, Alan Frazer, Daniel J Lodge
Background: Selective augmentation of hippocampal activity in ways similar to that caused by ketamine may have therapeutic advantages over ketamine, which has psychotomimetic and reinforcing effects likely due to effects outside the hippocampus (i.e., off-target effects). Methods: Here we evaluated the antidepressant-like response to a negative allosteric modulator of α5 subunit- containing gamma aminobutyric acid subtype A receptors, L-655,708, as these receptors are expressed to a much greater extent in the hippocampus than in other brain areas...
January 25, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28339573/augmented-h2s-production-via-cystathionine-beta-synthase-upregulation-plays-a-role-in-pregnancy-associated-uterine-vasodilation%C3%A2
#8
Lili Sheibani, Thomas J Lechuga, Honghai Zhang, Afshan Hameed, Deborah A Wing, Sathish Kumar, Charles R Rosenfeld, Dong-Bao Chen
Endogenous hydrogen sulfide (H2S) synthesized via metabolizing L-cysteine by cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) is a potent vasodilator and angiogenic factor. The objectives of this study were to determine if human uterine artery (UA) H2S production increases with augmented expression and/or activity of CBS and/or CSE during the menstrual cycle and pregnancy and whether exogenous H2S dilates UA. Uterine arteries from nonpregnant (NP) premenopausal proliferative (pPRM) and secretory (sPRM) phases of the menstrual cycle and pregnant (P) women were studied...
January 24, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28339452/reply-to-percutaneous-vertebral-augmentation-for-the-treatment-of-symptomatic-schmorl-s-nodes-our-viewpoint-and-experience
#9
Shi-Cheng He, Bin-Yan Zhong, Hai-Dong Zhu, Gao-Jun Teng
No abstract text is available yet for this article.
March 2017: Pain Physician
https://www.readbyqxmd.com/read/28339451/percutaneous-vertebral-augmentation-for-the-treatment-of-symptomatic-schmorl-s-nodes-our-viewpoint-and-experience
#10
Sun Zhi-Yong, Xiaoyu Zhu, Zhonglai Gian, Hui Lin Yang
No abstract text is available yet for this article.
March 2017: Pain Physician
https://www.readbyqxmd.com/read/28339443/clinical-outcome-of-augmentation-enterocystoplasty-for-patients-with-ketamine-induced-cystitis
#11
Yu Khun Lee, Jia-Fong Jhang, Hann-Chorng Kuo
BACKGROUND: Ketamine abuse has become a global phenomenon in recent years. Ketamine-induced cystitis (KC) is a new clinical syndrome which can result in severely inflamed bladder and intractable bladder pain. Currently there is no guideline for managing patients with KC. OBJECTIVES: To analyze the clinical outcome of patients with KC managed with augmentation enterocystoplasty (AE). STUDY DESIGN: Retrospective interventional study. SETTING: A tertiary teaching hospital, Hualien Tzu Chi Hospital...
March 2017: Pain Physician
https://www.readbyqxmd.com/read/28339256/analytic-interatomic-forces-in-the-random-phase-approximation
#12
Benjamin Ramberger, Tobias Schäfer, Georg Kresse
We discuss that in the random phase approximation (RPA) the first derivative of the energy with respect to the Green's function is the self-energy in the GW approximation. This relationship allows us to derive compact equations for the RPA interatomic forces. We also show that position dependent overlap operators are elegantly incorporated in the present framework. The RPA force equations have been implemented in the projector augmented wave formalism, and we present illustrative applications, including ab initio molecular dynamics simulations, the calculation of phonon dispersion relations for diamond and graphite, as well as structural relaxations for water on boron nitride...
March 10, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28339123/desolution-of-cd-and-cb-macrocycles
#13
Jade A McCune, Susanna Kunz, Magdalena Olesińska, Oren A Scherman
Supramolecular chemistry utilizing the macrocyclic hosts cyclodextrins (CDs) and cucurbit[n]urils (CB[n]s) is traditionally carried out in aqueous media, however, their solubility is typically poor, especially the family of cucurbit[n]urils. Through derivitization of these macrocycles their solubility can be augmented to enable enhanced solubility in water and in some organic solvents. The increase in solubility of these derivitized macrocycles allows for their use in a wider range of chemical environments and giving rise to myriad potential applications...
March 24, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28339088/sclerostin-is-a-possible-candidate-marker-of-arterial-stiffness-results-from-a-cohort-study-in-catania
#14
Agostino Gaudio, Valerio Fiore, Rosario Rapisarda, Maria Helga Sidoti, Anastasia Xourafa, Antonino Catalano, Giovanni Tringali, Luca Zanoli, Salvatore Santo Signorelli, Carmelo Erio Fiore
Osteoporosis and cardiovascular disease are worldwide public health issues. Recent evidence indicates a possible role of the canonical Wnt/β-catenin signalling pathway as a common mediator between these two diseases. The aim of the present study was to investigate the relationship between serum concentrations of sclerostin and Dkk1, two extracellular inhibitors of Wnt/β-catenin signalling, with carotid intima-media thickness (CIMT) and with arterial stiffness, evaluated by measuring the pulse wave velocity (PWV) in an ambulatory population of adults...
March 24, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28338977/effects-of-augmenting-n-methyl-d-aspartate-receptor-signaling-on-working-memory-and-experience-dependent-plasticity-in-schizophrenia-an-exploratory-study-using-acute-d-cycloserine
#15
Jennifer K Forsyth, Peter Bachman, Daniel H Mathalon, Brian J Roach, Elissa Ye, Robert F Asarnow
Cognitive deficits in schizophrenia have been hypothesized to reflect N-methyl-D-aspartate receptor (NMDAR) dysfunction. However, the mechanisms through which the NMDAR contributes to individual cognitive functions differ. To explore how NMDAR signaling relates to specific cognitive deficits in schizophrenia, we tested the effects of enhancing NMDAR signaling on working memory and experience-dependent plasticity using d-cycloserine (DCS). Plasticity was assessed using an EEG paradigm that utilizes high-frequency visual stimulation (HFvS) to induce neural potentiation, and 2 learning tasks, the information integration (IIT) and weather prediction (WPT) tasks...
March 17, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28338682/simple-peptides-derived-from-the-ribosomal-core-potentiate-rna-polymerase-ribozyme-function
#16
Shunsuke Tagami, James Attwater, Philipp Holliger
The emergence of functional interactions between nucleic acids and polypeptides was a key transition in the origin of life and remains at the heart of all biology. However, how and why simple non-coded peptides could have become critical for RNA function is unclear. Here, we show that putative ancient peptide segments from the cores of both ribosomal subunits enhance RNA polymerase ribozyme (RPR) function, as do derived homopolymeric peptides comprising lysine or the non-proteinogenic lysine analogues ornithine or, to a lesser extent, diaminobutyric acid, irrespective of chirality or chiral purity...
April 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28338586/towards-microsurgical-correction-of-cleft-lip-ex-utero-via-restoration-of-craniofacial-developmental-programs
#17
Xue Dong, Wilmina N Landford, James Hart, Maurizio Risolino, Omer Kaymakcalan, Julia Jin, Yoshiko Toyoda, Elisabetta Ferretti, Licia Selleri, Jason A Spector
BACKGROUND: Cleft Lip with or without Palate (CL/P) is present in approximately 1 in 500-700 live births, representing the most common congenital craniofacial anomaly. Previously, we developed a unique murine model with compound Pbx deficiency that exhibits fully penetrant CL/P. To investigate the possibility of tissue repair at an early gestational stage, we designed a minimally invasive surgical approach suitable for intrauterine repair using Wnt9b-soaked collagen microspheres to restore craniofacial developmental programs for cleft correction...
March 3, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28338544/associations-between-medication-class-and-subsequent-augmentation-of-depression-treatment-in-privately-insured-us-adults
#18
Omid Ameli, Rene Soria-Saucedo, Eric G Smith, Howard J Cabral, Marina Soley-Bori, Lewis E Kazis
IMPORTANCE: Treatment augmentation is an important clinical decision in the pharmacotherapy for depression, yet few studies have examined the rates of treatment augmentation by medication class. OBJECTIVE: The aim of this study was to examine which initial pharmacotherapies for depression are more likely than others to result in subsequent treatment augmentation. METHODS: This study is a retrospective cohort analysis of administrative data of 214,705 privately insured US adults between the age of 18 and 64 years who were diagnosed with a new episode of depression in 2009...
March 23, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28338507/ny-eso-1-protein-cancer-vaccine-with-poly-iclc-and-ok-432-rapid-and-strong-induction-of-ny-eso-1-specific-immune-responses-by-poly-iclc
#19
Tomohira Takeoka, Hirotsugu Nagase, Koji Kurose, Yoshihiro Ohue, Makoto Yamasaki, Shuji Takiguchi, Eiichi Sato, Midori Isobe, Takayuki Kanazawa, Mitsunobu Matsumoto, Kota Iwahori, Atsunari Kawashima, Akiko Morimoto-Okazawa, Hiroyoshi Nishikawa, Mikio Oka, Linda Pan, Ralph Venhaus, Eiichi Nakayama, Masaki Mori, Yuichiro Doki, Hisashi Wada
We conducted a clinical trial of a cancer vaccine using NY-ESO-1 protein with polyinosinic-polycytidylic acid-poly-L-lysine carboxymethylcellulose (poly-ICLC) and/or OK-432 against solid tumors. A total of 15 patients were sequentially enrolled in 4 cohorts. Patients in cohort 1 received NY-ESO-1 protein; cohort 2a received NY-ESO-1 protein+OK-432; cohort 2b received NY-ESO-1 protein+poly-ICLC; cohort 3 received NY-ESO-1 protein+OK-432+poly-ICLC with Montanide ISA-51. The endpoints of this trial were safety, NY-ESO-1 immune responses, and clinical response...
March 23, 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/28338488/respiratory-complications-management-and-treatments-for-neuromuscular-disease-in-children
#20
MyMy C Buu
PURPOSE OF REVIEW: To summarize current literature describing the respiratory complications of neuromuscular disease (NMD) and the effect of respiratory interventions and to explore new gene therapies for patients with NMD. RECENT FINDINGS: Measurements of respiratory function focus on vital capacity and maximal inspiratory and expiratory pressure and show decline over time. Management of respiratory complications includes lung volume recruitment, mechanical insufflation-exsufflation, chest physiotherapy and assisted ventilation...
March 23, 2017: Current Opinion in Pediatrics
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