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Keywords Respiratory therapy in critica...

Respiratory therapy in critically ill child

https://read.qxmd.com/read/36054491/prevalence-and-outcome-of-lymphopenia-in-the-paediatric-intensive-care-unit-a-prospective-observational-study
#21
JOURNAL ARTICLE
Karthi Nallasamy, Aidan Magee, K Johnny Millar, Trevor Duke
AIM: Leukopenia (lymphopenia or neutropenia) may be an important marker of altered immunity and risk in children with critical illness. We aimed to evaluate the prevalence, course, and outcome of leukopenia in children admitted to Paediatric Intensive Care Unit (PICU). METHODS: All consecutive children (n = 200) admitted to PICU for any reason except malignancy or pre-existing immune deficiency were enrolled during June-August 2018. RESULTS: Median (interquartile range) age was 2...
December 2022: Journal of Paediatrics and Child Health
https://read.qxmd.com/read/35748620/carotid-doppler-ultrasonography-as-a-method-to-predict-fluid-responsiveness-in-mechanically-ventilated-children
#22
JOURNAL ARTICLE
Thalita Belato de Souza, Aline Junqueira Rubio, Fernando de Lima Carioca, Isabel de Siqueira Ferraz, Marcelo Barciela Brandão, Roberto José Negrão Nogueira, Tiago Henrique de Souza
AIMS: The aim of this study was to investigate whether respiratory variations in carotid and aortic blood flows measured by Doppler ultrasonography could accurately predict fluid responsiveness in critically ill children. METHODS: This was a prospective single-center study including mechanically ventilated children who underwent fluid replacement at the discretion of the attending physician. Response to fluid load was defined by a stroke volume increase of more than 15%...
September 2022: Paediatric Anaesthesia
https://read.qxmd.com/read/35390113/effect-of-high-flow-nasal-cannula-therapy-vs-continuous-positive-airway-pressure-following-extubation-on-liberation-from-respiratory-support-in-critically-ill-children-a-randomized-clinical-trial
#23
RANDOMIZED CONTROLLED TRIAL
Padmanabhan Ramnarayan, Alvin Richards-Belle, Laura Drikite, Michelle Saull, Izabella Orzechowska, Robert Darnell, Zia Sadique, Julie Lester, Kevin P Morris, Lyvonne N Tume, Peter J Davis, Mark J Peters, Richard G Feltbower, Richard Grieve, Karen Thomas, Paul R Mouncey, David A Harrison, Kathryn M Rowan
IMPORTANCE: The optimal first-line mode of noninvasive respiratory support following extubation of critically ill children is not known. OBJECTIVE: To evaluate the noninferiority of high-flow nasal cannula (HFNC) therapy as the first-line mode of noninvasive respiratory support following extubation, compared with continuous positive airway pressure (CPAP), on time to liberation from respiratory support. DESIGN, SETTING, AND PARTICIPANTS: This was a pragmatic, multicenter, randomized, noninferiority trial conducted at 22 pediatric intensive care units in the United Kingdom...
April 26, 2022: JAMA
https://read.qxmd.com/read/35110859/severe-rhabdomyolysis-and-acute-renal-failure-treated-by-continuous-venovenous-hemodiafiltration-in-a-child-with-diabetic-ketoacidosis
#24
Ayhan Yaman
Diabetic ketoacidosis (DKA) is the most serious hyperglycemic emergency in patients with type I diabetes mellitus and is associated with significant morbidity and mortality. DKA may be a life-threatening condition due to severe clinical and biological impairments and treatment-associated complications [cerebral edema, acute respiratory failure, acute renal failure (ARF), hypokalemia, hypophosphatemia]. The development of ARF with rhabdomyolysis is a rare but potentially lethal disorder in children with DKA with an estimated mortality of about 50%...
January 2022: Indian Journal of Critical Care Medicine
https://read.qxmd.com/read/35022779/a-description-of-covid-19-directed-therapy-in-children-admitted-to-us-intensive-care-units-2020
#25
JOURNAL ARTICLE
Jennifer E Schuster, Natasha B Halasa, Mari Nakamura, Emily R Levy, Julie C Fitzgerald, Cameron C Young, Margaret M Newhams, Florence Bourgeois, Mary A Staat, Charlotte V Hobbs, Heda Dapul, Leora R Feldstein, Ashley M Jackson, Elizabeth H Mack, Tracie C Walker, Aline B Maddux, Philip C Spinella, Laura L Loftis, Michele Kong, Courtney M Rowan, Melania M Bembea, Gwenn E McLaughlin, Mark W Hall, Christopher J Babbitt, Mia Maamari, Matt S Zinter, Natalie Z Cvijanovich, Kelly N Michelson, Shira J Gertz, Christopher L Carroll, Neal J Thomas, John S Giuliano, Aalok R Singh, Saul R Hymes, Adam J Schwarz, John K McGuire, Ryan A Nofziger, Heidi R Flori, Katharine N Clouser, Kari Wellnitz, Melissa L Cullimore, Janet R Hume, Manish Patel, Adrienne G Randolph
BACKGROUND: It is unclear how acute coronavirus disease 2019 (COVID-19)-directed therapies are used in children with life-threatening COVID-19 in US hospitals. We described characteristics of children hospitalized in the intensive care unit or step-down unit (ICU/SDU) who received COVID-19-directed therapies and the specific therapies administered. METHODS: Between March 15, 2020 and December 27, 2020, children <18 years of age in the ICU/SDU with acute COVID-19 at 48 pediatric hospitals in the United States were identified...
May 30, 2022: Journal of the Pediatric Infectious Diseases Society
https://read.qxmd.com/read/34981683/analysis-of-critical-covid-19-cases-among-children-in-korea
#26
JOURNAL ARTICLE
Hyunju Lee, Sujin Choi, Ji Young Park, Dae Sun Jo, Ui Yoon Choi, Heayon Lee, Yun Tae Jung, In Hyuk Chung, Young June Choe, Jin Yong Kim, Young-Joon Park, Eun Hwa Choi
BACKGROUND: Coronavirus disease 2019 (COVID-19) is generally asymptomatic or mild in otherwise healthy children, however, severe cases may occur. In this study, we report the clinical characteristics of children classified as critical COVID-19 in Korea to provide further insights into risk factors and management in children. METHODS: This study was a retrospective case series of children < 18 years of age classified as critical COVID-19. Cases were identified by the Korea Disease Control and Prevention Agency surveillance system and medical records were reviewed...
January 3, 2022: Journal of Korean Medical Science
https://read.qxmd.com/read/34966143/individual-meropenem-clearance-in-infants-on-ecmo-and-cvvhdf-is-difficult-to-predict-a-case-report-and-review-of-the-literature
#27
JOURNAL ARTICLE
Ali Jabareen, Laila Nassar, Marina Karasik, Edna Efrati, Amir Hadash, Imad Kassis, Daniel Kurnik
OBJECTIVES: Meropenem is a broad-spectrum carbapenem antibiotic with mostly renal excretion. Conflicting data are available regarding meropenem pharmacokinetics in critically ill neonates on concomitant continuous renal replacement therapy (CRRT) and/or extracorporeal membrane oxygenation (ECMO). Our objectives were to assess meropenem clearance in a neonate on CRRT and ECMO, compare it to previously published data and assess whether dose recommendations can be generalized in this population...
February 1, 2022: Pediatric Infectious Disease Journal
https://read.qxmd.com/read/34943344/characteristics-of-surgical-necrotizing-enterocolitis-is-it-different-from-medical-necrotizing-enterocolitis-a-single-center-retrospective-study
#28
JOURNAL ARTICLE
Ara Cho, Dayoung Ko, JoongKee Youn, Hee-Beom Yang, Hyun-Young Kim
(1) Background: Necrotizing enterocolitis (NEC) is one of the leading causes of death in newborns despite improvements in the care of critically ill neonates. Approximately 50-70% of the cases are managed by medical therapy. However, the remaining patients require surgical intervention. The purpose of our study was to analyze the factors associated with patients requiring surgical treatment compared to patients requiring only medical treatment; (2) Method: Patients diagnosed with necrotizing enterocolitis over a period of 14 years (January 2003-December 2016) in a single tertiary referral children's hospital were retrospectively enrolled...
December 6, 2021: Children
https://read.qxmd.com/read/34889518/sirolimus-efficacy-in-the-treatment-of-critically-ill-infants-with-congenital-primary-chylous-effusions
#29
JOURNAL ARTICLE
Shreya Agarwal, Berkley Kingman Anderson, Priya Mahajan, Caraciolo J Fernandes, Judith F Margolin, Ionela Iacobas
BACKGROUND: Chylothorax can be a presenting symptom of complex lymphatic anomaly in children and is associated with significant respiratory morbidity. Historically, the traditional pharmacological treatment has been octreotide. There are several treatments that have been utilized in the past few years including sirolimus; however, data regarding their efficacy and outcomes is limited. Furthermore, sirolimus has proven efficacy in complex vascular malformations, and hence, its utility/efficacy in infantile primary chylous effusions warrants further investigation...
February 2022: Pediatric Blood & Cancer
https://read.qxmd.com/read/34865169/comparison-of-clinical-findings-in-sars-cov-2-with-other-respiratory-viruses-in-critically-ill-children-during-the-covid-19-pandemic
#30
JOURNAL ARTICLE
Oktay Perk, Serhan Ozcan, Serhat Emeksiz, Emel Uyar, Belgin Gulhan
OBJECTIVES: The aim of this study was to compare the clinical and laboratory findings in SARS-CoV-2 (COVID-19) with those of other respiratory viruses in critically ill children. METHODS: It is a single center retrospective descriptive study conducted in a 32-bed pediatric intensive care unit (PICU). Our study was performed in Ankara City Hospital, Ankara, Turkey, between 1 March 2020, and 1 March 2021. Demographic and clinical characteristics of the patients were collected and we recorded the antibiotic use, antiviral treatments, respiratory and extracorporeal supports, PICU stay and survival rates...
December 8, 2021: Journal of Tropical Pediatrics
https://read.qxmd.com/read/34636357/strain-echocardiography-and-myocardial-dysfunction-in-critically-ill-children-with-multisystem-inflammatory-syndrome-unrecognized-by-conventional-echocardiography-a-retrospective-cohort-analysis
#31
JOURNAL ARTICLE
Sonali Basu, Esther J Kim, Matthew P Sharron, Ashley Austin, Murray M Pollack, Ashraf S Harahsheh, Niti Dham
OBJECTIVES: Multisystem inflammatory syndrome in children is a newly defined complication of severe acute respiratory syndrome coronavirus 2 infection that can result in cardiogenic shock in the pediatric population. Early detection of cardiac dysfunction is imperative in directing therapy and identifying patients at highest risk for deterioration. This study compares the strengths of conventional and strain echocardiography in identifying cardiac dysfunction in critically ill children with multisystem inflammatory syndrome in children and their association with ICU therapeutic needs and clinical outcomes...
March 1, 2022: Pediatric Critical Care Medicine
https://read.qxmd.com/read/34582635/management-of-perinatal-hpp-during-critical-illness-ecmo
#32
Neetu Krishnan, Nancy Dunbar
OBJECTIVES: With the advent of asfotase alfa, the enzyme replacement therapy (ERT) approved for hypophosphatasia (HPP), health care providers need to navigate management of ERT during critical illness. CASE PRESENTATION: We present the case of a young girl, treated with ERT for severe perinatal HPP, who had cardiorespiratory arrest in the setting of influenza A. Her life-saving treatment involving extra corporeal membrane oxygenation (ECMO) required a two-week interruption of ERT leading to persistent hypercalcemia and hyperphosphatemia...
September 27, 2021: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://read.qxmd.com/read/34552014/inhaled-nitric-oxide-use-and-outcomes-in-critically-ill-children-with-a-history-of-prematurity
#33
MULTICENTER STUDY
Aline B Maddux, Peter M Mourani, Russell Banks, Ron W Reeder, Murray M Pollack, Robert A Berg, Kathleen L Meert, Patrick S McQuillen, Andrew R Yates, Daniel A Notterman, John T Berger
BACKGROUND: Inhaled nitric oxide (INO) is used to treat hypoxic respiratory failure without clear evidence of benefit. Future trials to evaluate its use will be designed based on an understanding of the populations in which this therapy is provided and with outcomes based on patient characteristics, for example, a history of premature birth. METHODS: This was a multi-center prospective observational study that evaluated subjects in the pediatric ICU who were treated with INO for a respiratory indication, excluding those treated in the neonatal ICU or treated for birth-related disease...
October 2021: Respiratory Care
https://read.qxmd.com/read/34261946/long-term-increases-in-mental-disorder-diagnoses-after-invasive-mechanical-ventilation-for-severe-childhood-respiratory-disease-a-propensity-matched-observational-cohort-study
#34
JOURNAL ARTICLE
Andrew S Geneslaw, Yewei Lu, Caleb H Miles, May Hua, Joshua Cappell, Arthur J Smerling, Mark Olfson, Jeffrey D Edwards, Caleb Ing
OBJECTIVES: To evaluate neurodevelopmental and mental disorders after PICU hospitalization in children requiring invasive mechanical ventilation for severe respiratory illness. DESIGN: Retrospective longitudinal observational cohort. SETTING: Texas Medicaid Analytic eXtract data from 1999 to 2012. PATIENTS: Texas Medicaid-enrolled children greater than or equal to 28 days old to less than 18 years old hospitalized for a primary respiratory illness, without major chronic conditions predictive of abnormal neurodevelopment...
December 1, 2021: Pediatric Critical Care Medicine
https://read.qxmd.com/read/34246544/ethical-considerations-in-pediatric-chronic-illness-the-relationship-between-psychological-factors-treatment-adherence-and-health-outcomes
#35
REVIEW
Jennifer M Rohan, Marcia A Winter
Children, adolescents, and young adults with chronic illnesses are often faced with complicated and burdensome treatments that not only require a great deal of time and energy to manage, but will also likely impact relationships with parents, siblings, and peers. Adolescents and young adults with chronic illness are often impacted by several unique and challenging factors that can ultimately impact health behaviors and treatment outcomes. Working with a psychologist can help to ameliorate these unique challenges, which will positively impact health behaviors and health outcomes...
May 31, 2021: Paediatric Respiratory Reviews
https://read.qxmd.com/read/34170328/intensive-care-needs-and-short-term-outcome-of-multisystem-inflammatory-syndrome-in-children-mis-c-experience-from-north-india
#36
JOURNAL ARTICLE
Suresh Kumar Angurana, Puspraj Awasthi, Ajay Thakur, Manjinder Singh Randhawa, Karthi Nallasamy, Manoj Rohit Kumar, Sanjeev Naganur, Mahendra Kumar, Kapil Goyal, Arnab Ghosh, Arun Bansal, Muralidharan Jayashree
OBJECTIVES: To describe the intensive care needs and outcome of multisystem inflammatory syndrome in children (MIS-C). METHODOLOGY: This retrospective study was conducted in the pediatric emergency, pediatric intensive care unit (PICUs) and the coronavirus disease 2019 (COVID 19) hospital of a tertiary teaching and referral hospital in North India over a period of 5 months (September 2020 to January 2021). Clinical details, laboratory investigations, intensive care needs, treatment and short-term outcome were recorded...
July 2, 2021: Journal of Tropical Pediatrics
https://read.qxmd.com/read/34137700/-clinical-characteristics-of-sars-cov-2-disease-covid-19-in-middle-aged-patients
#37
JOURNAL ARTICLE
Ariel A Baletto, S Gonzalo Acosta, Franco Piasterlini, Cecilia Barrios, Indalecio Carboni Bisso, Eleno Martinez Aquino
Coronavirus disease 2019 (COVID-19) meant an unprecedented global crisis, which involved the reorganization of health systems and the rationalization of available diagnostic and therapeutic resources. The objective of this observational and retrospective study was to analyze the clinical characteristics and evolution of patients admitted to general ward, intensive care unit and emergency department of a high complexity hospital in Buenos Aires city, during the first seven months of viral circulation. A total of 1005 patients with laboratory-confirmed COVID-19 were included...
2021: Medicina
https://read.qxmd.com/read/34081145/severe-coronavirus-disease-pneumonia-in-pediatric-patients-in-a-referral-hospital
#38
JOURNAL ARTICLE
Serhan Ozcan, Serhat Emeksiz, Oktay Perk, Emel Uyar, Saliha Kanik Yüksek
OBJECTIVE: We aimed to evaluate the characteristics and outcomes of critically ill children managed in an intensive care unit because of coronavirus disease (COVID-19) pneumonia with respiratory support requirements. METHODS: We performed a single-center retrospective observational study in a pediatric intensive care unit (PICU) with 32 beds in Ankara City Hospital, Ankara, Turkey, from 13 March 2020 to 31 December 2020. Patients who needed positive-pressure ventilation (PPV) therapy for COVID-19 pneumonia were included in the study...
July 2, 2021: Journal of Tropical Pediatrics
https://read.qxmd.com/read/33949205/assessment-and-impact-of-intravenous-medication-fluid-administration-in-critically-ill-patients-with-acute-respiratory-failure
#39
JOURNAL ARTICLE
Jeffrey P Gonzales, Debbi Child, Thelma Harrington, Peter Kratz, Laura Seiberlich, Giora Netzer, Carl B Shanholtz
BACKGROUND: Positive fluid balance early in critical illness is associated with poor outcomes. Reducing intravenous medication volume may mitigate volume overload. Objective: Assessment of fluid and medication administration and clinical outcomes in acute respiratory failure. METHODS: Single-center, prospective observational study of hemodynamically stable adult patients in a medical intensive care unit (MICU) with acute respiratory failure. RESULTS: Median cumulative total intake volume was 12 890 (interquartile range [IQR] = 8654-22 221) mL (n = 27), and median cumulative intravenous medication volume was 3563 (IQR = 2371-9412) mL over the first 7 days...
May 5, 2021: Annals of Pharmacotherapy
https://read.qxmd.com/read/33715760/clinical-and-therapeutic-approach-to-hospitalized-covid-19-patients-a-pediatric-cohort-in-portugal
#40
JOURNAL ARTICLE
Bárbara Martins Saraiva, Ana Margarida Garcia, Tiago Milheiro Silva, Catarina Gouveia, Maria João Brito
INTRODUCTION: Coronavirus disease 2019, or COVID-19, in children is usually a mild disease, but severe illness has been reported. Currently, the therapy benefits of antiviral experimental drugs are still uncertain. The main aim of this study is to describe the experience of a level III hospital regarding therapeutic management of hospitalized children with COVID-19 and to characterize clinical features and evolution. MATERIAL AND METHODS: This is a descriptive study of patients with COVID-19 in a level III pediatric hospital in Portugal between March and June 2020...
March 12, 2021: Acta Médica Portuguesa
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